locus-tag	class	description
TthSNM33_00010	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
TthSNM33_00020	COG0592	DNA-directed DNA polymerase activity
TthSNM33_00030	COG0148	phosphopyruvate hydratase activity
TthSNM33_00040	COG0469	pyruvate kinase activity
TthSNM33_00060	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
TthSNM33_00070	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
TthSNM33_00090	COG1842	Phage shock protein A
TthSNM33_00120	COG0406	alpha-ribazole phosphatase activity
TthSNM33_00130	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
TthSNM33_00140	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
TthSNM33_00160	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
TthSNM33_00170	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
TthSNM33_00180	COG1496	oxidoreductase activity
TthSNM33_00190	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
TthSNM33_00200	COG1278	Cold shock
TthSNM33_00250	COG0395	ABC-type sugar transport system, permease component
TthSNM33_00260	COG0033	Phosphoglucomutase
TthSNM33_00300	COG0517	IMP dehydrogenase activity
TthSNM33_00300	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
TthSNM33_00310	COG1950	PFAM Membrane protein of
TthSNM33_00320	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
TthSNM33_00340	COG0181	hydroxymethylbilane synthase activity
TthSNM33_00360	COG0285	dihydrofolate synthase activity
TthSNM33_00370	COG0436	Aminotransferase
TthSNM33_00380	COG0521	Mo-molybdopterin cofactor biosynthetic process
TthSNM33_00430	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
TthSNM33_00440	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
TthSNM33_00450	COG1993	acr, cog1993
TthSNM33_00460	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
TthSNM33_00480	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
TthSNM33_00500	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
TthSNM33_00510	COG1335	isochorismatase
TthSNM33_00520	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
TthSNM33_00550	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
TthSNM33_00560	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
TthSNM33_00600	COG1660	Displays ATPase and GTPase activities
TthSNM33_00610	COG0391	Required for morphogenesis under gluconeogenic growth conditions
TthSNM33_00670	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
TthSNM33_00670	COG1845	cytochrome c oxidase, subunit III
TthSNM33_00680	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
TthSNM33_00680	COG2010	Cytochrome c
TthSNM33_00690	COG1612	heme a metabolic process
TthSNM33_00690	COG0109	protoheme IX farnesyltransferase activity
TthSNM33_00720	COG0343	queuine tRNA-ribosyltransferase activity
TthSNM33_00730	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
TthSNM33_00740	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
TthSNM33_00790	COG1940	carbohydrate kinase activity
TthSNM33_00810	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
TthSNM33_00820	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
TthSNM33_00840	COG1611	Belongs to the LOG family
TthSNM33_00860	COG1011	Hydrolase
TthSNM33_00870	COG0632	four-way junction helicase activity
TthSNM33_00880	COG1024	Enoyl-CoA hydratase
TthSNM33_00900	COG0508	dehydrogenase complex catalyzes the overall conversion of
TthSNM33_00920	COG0137	argininosuccinate synthase activity
TthSNM33_00930	COG0165	Argininosuccinate lyase
TthSNM33_00960	COG0505	Belongs to the CarA family
TthSNM33_00980	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
TthSNM33_00990	COG0166	Belongs to the GPI family
TthSNM33_01010	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
TthSNM33_01020	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
TthSNM33_01030	COG0459	protein refolding
TthSNM33_01040	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
TthSNM33_01050	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
TthSNM33_01070	COG0778	Nitroreductase
TthSNM33_01080	COG0791	NLP P60 protein
TthSNM33_01080	COG1388	LysM domain
TthSNM33_01100	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
TthSNM33_01120	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
TthSNM33_01130	COG0581	inorganic phosphate transmembrane transporter activity
TthSNM33_01140	COG0573	inorganic phosphate transmembrane transporter activity
TthSNM33_01160	COG0482	sulfurtransferase activity
TthSNM33_01180	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
TthSNM33_01190	COG0735	belongs to the Fur family
TthSNM33_01220	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
TthSNM33_01230	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
TthSNM33_01240	COG0267	Belongs to the bacterial ribosomal protein bL33 family
TthSNM33_01250	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
TthSNM33_01260	COG0250	Participates in transcription elongation, termination and antitermination
TthSNM33_01280	COG0081	regulation of translation
TthSNM33_01320	COG0629	single-stranded DNA binding
TthSNM33_01330	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
TthSNM33_01340	COG0359	binds to the 23S rRNA
TthSNM33_01360	COG0300	oxidoreductase activity
TthSNM33_01370	COG0321	lipoyl(octanoyl) transferase activity
TthSNM33_01380	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
TthSNM33_01460	COG1476	TRANSCRIPTIONal
TthSNM33_01490	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
TthSNM33_01520	COG1598	PFAM Uncharacterised protein family UPF0150
TthSNM33_01530	COG0022	dehydrogenase e1 component
TthSNM33_01540	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
TthSNM33_01550	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
TthSNM33_01600	COG2226	methyltransferase
TthSNM33_01610	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
TthSNM33_01630	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
TthSNM33_01640	COG1187	pseudouridine synthase activity
TthSNM33_01660	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
TthSNM33_01670	COG0686	Belongs to the AlaDH PNT family
TthSNM33_01720	COG3583	domain protein
TthSNM33_01720	COG3584	3D domain protein
TthSNM33_01730	COG4591	ABC-type transport system involved in lipoprotein release permease component
TthSNM33_01740	COG0222	ribosome binding
TthSNM33_01750	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
TthSNM33_01780	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
TthSNM33_01810	COG0697	spore germination
TthSNM33_01830	COG3177	Filamentation induced by cAMP protein fic
TthSNM33_01850	COG0243	molybdopterin cofactor binding
TthSNM33_01860	COG2272	Belongs to the type-B carboxylesterase lipase family
TthSNM33_01870	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
TthSNM33_01890	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
TthSNM33_01920	COG0477	Major facilitator Superfamily
TthSNM33_01950	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
TthSNM33_01970	COG0105	UTP biosynthetic process
TthSNM33_01980	COG0631	protein serine/threonine phosphatase activity
TthSNM33_01990	COG0583	DNA-binding transcription factor activity
TthSNM33_02010	COG0508	dehydrogenase complex catalyzes the overall conversion of
TthSNM33_02080	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
TthSNM33_02100	COG1278	Cold shock
TthSNM33_02110	COG0484	heat shock protein binding
TthSNM33_02120	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
TthSNM33_02130	COG1968	undecaprenyl-diphosphatase activity
TthSNM33_02140	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
TthSNM33_02150	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
TthSNM33_02190	COG1309	transcriptional regulator
TthSNM33_02200	COG4242	Belongs to the peptidase S51 family
TthSNM33_02230	COG0802	atpase or kinase
TthSNM33_02240	COG0539	negative regulation of cytoplasmic translation
TthSNM33_02250	COG0495	leucyl-tRNA aminoacylation
TthSNM33_02310	COG1902	pentaerythritol trinitrate reductase activity
TthSNM33_02360	COG2414	aldehyde ferredoxin oxidoreductase
TthSNM33_02400	COG1187	pseudouridine synthase activity
TthSNM33_02420	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
TthSNM33_02430	COG0745	RESPONSE REGULATOR receiver
TthSNM33_02440	COG4191	Histidine kinase
TthSNM33_02450	COG0704	Plays a role in the regulation of phosphate uptake
TthSNM33_02460	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
TthSNM33_02480	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
TthSNM33_02500	COG0515	serine threonine protein kinase
TthSNM33_02500	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
TthSNM33_02560	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
TthSNM33_02570	COG4221	oxidoreductase activity
TthSNM33_02600	COG0717	Belongs to the dCTP deaminase family
TthSNM33_02610	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
TthSNM33_02620	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
TthSNM33_02630	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
TthSNM33_02680	COG3546	catalase activity
TthSNM33_02690	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
TthSNM33_02690	COG0758	DNA mediated transformation
TthSNM33_02700	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
TthSNM33_02720	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
TthSNM33_02740	COG3635	2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity
TthSNM33_02750	COG0442	prolyl-tRNA aminoacylation
TthSNM33_02760	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
TthSNM33_02800	COG0303	'Molybdopterin
TthSNM33_02810	COG0513	Belongs to the DEAD box helicase family
TthSNM33_02840	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
TthSNM33_02870	COG2070	2-Nitropropane dioxygenase
TthSNM33_02900	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
TthSNM33_02910	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
TthSNM33_02920	COG0018	arginyl-trna synthetase
TthSNM33_02930	COG1007	ATP synthesis coupled electron transport
TthSNM33_02940	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
TthSNM33_02950	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
TthSNM33_02960	COG0713	ATP synthesis coupled electron transport
TthSNM33_02970	COG0839	Belongs to the complex I subunit 6 family
TthSNM33_02980	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
TthSNM33_02990	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
TthSNM33_03000	COG1034	ATP synthesis coupled electron transport
TthSNM33_03010	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
TthSNM33_03020	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
TthSNM33_03030	COG0649	NAD binding
TthSNM33_03040	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
TthSNM33_03050	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
TthSNM33_03060	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
TthSNM33_03070	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
TthSNM33_03090	COG4712	double-strand break repair protein
TthSNM33_03120	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
TthSNM33_03150	COG0135	phosphoribosylanthranilate isomerase activity
TthSNM33_03160	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
TthSNM33_03160	COG1372	Participates in initiation and elongation during chromosome replication
TthSNM33_03170	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
TthSNM33_03190	COG2720	vancomycin resistance protein
TthSNM33_03200	COG1126	abc transporter atp-binding protein
TthSNM33_03260	COG0277	FAD linked oxidase domain protein
TthSNM33_03280	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
TthSNM33_03290	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
TthSNM33_03320	COG0314	molybdopterin synthase activity
TthSNM33_03330	COG1420	regulation of RNA biosynthetic process
TthSNM33_03340	COG0347	Belongs to the P(II) protein family
TthSNM33_03370	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
TthSNM33_03390	COG0123	including yeast histone deacetylase and acetoin utilization protein
TthSNM33_03420	COG1597	lipid kinase activity
TthSNM33_03430	COG0436	Aminotransferase
TthSNM33_03450	COG0475	glutathione-regulated potassium exporter activity
TthSNM33_03450	COG0569	domain protein
TthSNM33_03470	COG0227	Belongs to the bacterial ribosomal protein bL28 family
TthSNM33_03490	COG0277	FAD linked oxidase domain protein
TthSNM33_03590	COG2002	toxin-antitoxin pair type II binding
TthSNM33_03660	COG0667	Aldo Keto reductase
TthSNM33_03740	COG1067	ATP-dependent peptidase activity
TthSNM33_03750	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
TthSNM33_03770	COG0745	RESPONSE REGULATOR receiver
TthSNM33_03780	COG2105	PFAM AIG2 family protein
TthSNM33_03790	COG0297	glycogen (starch) synthase activity
TthSNM33_03810	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
TthSNM33_03820	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
TthSNM33_03850	COG0142	geranyltranstransferase activity
TthSNM33_03870	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
TthSNM33_03900	COG1028	Short-chain dehydrogenase reductase Sdr
TthSNM33_03910	COG0492	ferredoxin-NADP+ reductase activity
TthSNM33_03930	COG0792	nuclease activity
TthSNM33_03940	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
TthSNM33_03970	COG1175	transmembrane transport
TthSNM33_03980	COG0395	ABC-type sugar transport system, permease component
TthSNM33_04000	COG3335	DDE superfamily endonuclease
TthSNM33_04060	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
TthSNM33_04070	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
TthSNM33_04100	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
TthSNM33_04110	COG0805	protein transport
TthSNM33_04120	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
TthSNM33_04120	COG1605	Chorismate mutase
TthSNM33_04240	COG1063	alcohol dehydrogenase
TthSNM33_04300	COG2255	four-way junction helicase activity
TthSNM33_04310	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
TthSNM33_04320	COG0564	pseudouridine synthase activity
TthSNM33_04350	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
TthSNM33_04360	COG0232	Belongs to the dGTPase family. Type 2 subfamily
TthSNM33_04370	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
TthSNM33_04380	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
TthSNM33_04400	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
TthSNM33_04410	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
TthSNM33_04420	COG0333	Belongs to the bacterial ribosomal protein bL32 family
TthSNM33_04490	COG0778	Nitroreductase
TthSNM33_04520	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
TthSNM33_04530	COG0131	Imidazoleglycerol-phosphate dehydratase
TthSNM33_04540	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
TthSNM33_04550	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
TthSNM33_04560	COG0517	IMP dehydrogenase activity
TthSNM33_04560	COG0516	GMP reductase activity
TthSNM33_04590	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
TthSNM33_04620	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
TthSNM33_04670	COG0706	membrane insertase activity
TthSNM33_04680	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
TthSNM33_04690	COG0594	ribonuclease P activity
TthSNM33_04720	COG1022	Amp-dependent synthetase and ligase
TthSNM33_04770	COG1121	(ABC) transporter
TthSNM33_04780	COG1108	ABC-type Mn2 Zn2 transport systems permease components
TthSNM33_04790	COG1959	2 iron, 2 sulfur cluster binding
TthSNM33_04800	COG1104	cysteine desulfurase activity
TthSNM33_04810	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
TthSNM33_04820	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
TthSNM33_04850	COG1028	Short-chain dehydrogenase reductase Sdr
TthSNM33_04890	COG0492	ferredoxin-NADP+ reductase activity
TthSNM33_04900	COG0604	alcohol dehydrogenase
TthSNM33_04900	COG3321	synthase
TthSNM33_04900	COG1028	Short-chain dehydrogenase reductase Sdr
TthSNM33_04910	COG0747	negative chemotaxis
TthSNM33_04920	COG0601	transmembrane transport
TthSNM33_04930	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
TthSNM33_04960	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
TthSNM33_04960	COG0617	tRNA 3'-terminal CCA addition
TthSNM33_04960	COG0517	IMP dehydrogenase activity
TthSNM33_04970	COG0123	including yeast histone deacetylase and acetoin utilization protein
TthSNM33_04980	COG2104	thiamine diphosphate biosynthetic process
TthSNM33_04990	COG0037	tRNA processing
TthSNM33_05020	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
TthSNM33_05050	COG4176	ABC-type proline glycine betaine transport system permease component
TthSNM33_05060	COG3448	diguanylate cyclase activity
TthSNM33_05060	COG4175	Glycine betaine
TthSNM33_05070	COG0366	Alpha amylase catalytic
TthSNM33_05080	COG2226	methyltransferase
TthSNM33_05090	COG2226	methyltransferase
TthSNM33_05100	COG0815	Transfers the fatty acyl group on membrane lipoproteins
TthSNM33_05120	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
TthSNM33_05130	COG3744	PilT protein domain protein
TthSNM33_05150	COG0460	homoserine dehydrogenase
TthSNM33_05170	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
TthSNM33_05230	COG0635	Involved in the biosynthesis of porphyrin-containing compound
TthSNM33_05260	COG0247	lactate metabolic process
TthSNM33_05270	COG0277	FAD linked oxidase domain protein
TthSNM33_05280	COG0277	FAD linked oxidase domain protein
TthSNM33_05290	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
TthSNM33_05300	COG1414	Transcriptional regulator
TthSNM33_05310	COG0789	Transcriptional regulator
TthSNM33_05330	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
TthSNM33_05340	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
TthSNM33_05410	COG0861	Integral membrane protein TerC family
TthSNM33_05420	COG2151	metal-sulfur cluster biosynthetic enzyme
TthSNM33_05430	COG0281	malic enzyme
TthSNM33_05460	COG0404	The glycine cleavage system catalyzes the degradation of glycine
TthSNM33_05470	COG0509	glycine decarboxylation via glycine cleavage system
TthSNM33_05480	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
TthSNM33_05490	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
TthSNM33_05500	COG0196	riboflavin kinase activity
TthSNM33_05550	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
TthSNM33_05560	COG2813	Specifically methylates the guanine in position
TthSNM33_05570	COG0527	aspartate kinase activity
TthSNM33_05630	COG4956	integral membrane protein (PIN domain superfamily)
TthSNM33_05640	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
TthSNM33_05650	COG0542	response to heat
TthSNM33_05660	COG0423	glycine-tRNA ligase activity
TthSNM33_05690	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
TthSNM33_05730	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
TthSNM33_05730	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
TthSNM33_05750	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
TthSNM33_05770	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
TthSNM33_05790	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
TthSNM33_05800	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
TthSNM33_05810	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
TthSNM33_05820	COG0114	fumarate hydratase activity
TthSNM33_05830	COG0183	Belongs to the thiolase family
TthSNM33_05860	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
TthSNM33_05870	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
TthSNM33_05900	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
TthSNM33_05910	COG1254	Belongs to the acylphosphatase family
TthSNM33_05940	COG1063	alcohol dehydrogenase
TthSNM33_05950	COG2133	pyrroloquinoline quinone binding
TthSNM33_05970	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
TthSNM33_05980	COG0154	amidase activity
TthSNM33_05990	COG2176	DNA-directed DNA polymerase activity
TthSNM33_06030	COG0572	uridine kinase
TthSNM33_06040	COG3842	ATPase activity
TthSNM33_06070	COG4475	Protein of unknown function (DUF436)
TthSNM33_06230	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
TthSNM33_06240	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
TthSNM33_06250	COG0803	Belongs to the bacterial solute-binding protein 9 family
TthSNM33_06280	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
TthSNM33_06290	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
TthSNM33_06300	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
TthSNM33_06310	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
TthSNM33_06330	COG1028	Short-chain dehydrogenase reductase Sdr
TthSNM33_06340	COG0318	PFAM AMP-dependent synthetase and ligase
TthSNM33_06350	COG2030	dehydratase
TthSNM33_06350	COG1012	belongs to the aldehyde dehydrogenase family
TthSNM33_06360	COG1960	acyl-CoA dehydrogenase activity
TthSNM33_06390	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
TthSNM33_06400	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
TthSNM33_06410	COG1293	RNA-binding protein homologous to eukaryotic snRNP
TthSNM33_06420	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
TthSNM33_06440	COG3870	Protein conserved in bacteria
TthSNM33_06450	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
TthSNM33_06470	COG0544	peptidyl-prolyl cis-trans isomerase activity
TthSNM33_06480	COG0740	serine-type endopeptidase activity
TthSNM33_06490	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
TthSNM33_06500	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
TthSNM33_06510	COG0646	methionine synthase
TthSNM33_06510	COG1410	methionine synthase
TthSNM33_06530	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
TthSNM33_06580	COG1692	metallophosphoesterase
TthSNM33_06590	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
TthSNM33_06600	COG1970	mechanosensitive ion channel activity
TthSNM33_06680	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
TthSNM33_06700	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
TthSNM33_06710	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
TthSNM33_06820	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
TthSNM33_06880	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
TthSNM33_06920	COG0489	protein tyrosine kinase activity
TthSNM33_06940	COG2264	protein methyltransferase activity
TthSNM33_06950	COG1385	rRNA (uridine-N3-)-methyltransferase activity
TthSNM33_07010	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
TthSNM33_07010	COG0574	Belongs to the PEP-utilizing enzyme family
TthSNM33_07030	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
TthSNM33_07040	COG2046	Belongs to the sulfate adenylyltransferase family
TthSNM33_07050	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
TthSNM33_07050	COG1648	precorrin-2 dehydrogenase activity
TthSNM33_07060	COG0730	response to heat
TthSNM33_07070	COG0175	sulfate reduction
TthSNM33_07080	COG1648	precorrin-2 dehydrogenase activity
TthSNM33_07080	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
TthSNM33_07090	COG1587	Uroporphyrinogen-III synthase
TthSNM33_07100	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
TthSNM33_07120	COG0352	thiamine-phosphate diphosphorylase activity
TthSNM33_07130	COG2104	thiamine diphosphate biosynthetic process
TthSNM33_07140	COG2022	thiamine diphosphate biosynthetic process
TthSNM33_07150	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
TthSNM33_07150	COG2022	thiamine diphosphate biosynthetic process
TthSNM33_07160	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
TthSNM33_07170	COG0477	Major facilitator Superfamily
TthSNM33_07180	COG0351	phosphomethylpyrimidine kinase
TthSNM33_07240	COG1175	transmembrane transport
TthSNM33_07260	COG1940	carbohydrate kinase activity
TthSNM33_07270	COG0183	Belongs to the thiolase family
TthSNM33_07300	COG1028	Short-chain dehydrogenase reductase Sdr
TthSNM33_07370	COG1012	belongs to the aldehyde dehydrogenase family
TthSNM33_07430	COG3835	regulator
TthSNM33_07470	COG0559	Belongs to the binding-protein-dependent transport system permease family
TthSNM33_07490	COG2030	dehydratase
TthSNM33_07510	COG0596	Alpha beta hydrolase
TthSNM33_07520	COG0318	PFAM AMP-dependent synthetase and ligase
TthSNM33_07550	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
TthSNM33_07550	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
TthSNM33_07570	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
TthSNM33_07590	COG0195	Participates in both transcription termination and antitermination
TthSNM33_07600	COG0779	Required for maturation of 30S ribosomal subunits
TthSNM33_07610	COG0739	heme binding
TthSNM33_07620	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
TthSNM33_07630	COG0640	Transcriptional regulator
TthSNM33_07640	COG2217	Heavy metal translocating P-type atpase
TthSNM33_07650	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
TthSNM33_07660	COG0017	Asparaginyl-tRNA synthetase
TthSNM33_07670	COG0561	phosphatase activity
TthSNM33_07680	COG0384	phenazine biosynthesis protein PhzF
TthSNM33_07700	COG0124	histidyl-tRNA synthetase
TthSNM33_07720	COG3842	ATPase activity
TthSNM33_07760	COG1573	uracil-dna glycosylase
TthSNM33_07800	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
TthSNM33_07840	COG1316	TRANSCRIPTIONal
TthSNM33_07870	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
TthSNM33_07960	COG0295	cytidine deaminase activity
TthSNM33_07980	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
TthSNM33_08000	COG1760	l-serine dehydratase
TthSNM33_08020	COG0481	GTPase activity
TthSNM33_08050	COG0463	Glycosyl transferase, family 2
TthSNM33_08080	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
TthSNM33_08110	COG1028	Short-chain dehydrogenase reductase Sdr
TthSNM33_08160	COG0405	Gamma-glutamyltransferase
TthSNM33_08170	COG1073	alpha beta
TthSNM33_08200	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
TthSNM33_08210	COG2873	o-acetylhomoserine
TthSNM33_08240	COG1063	alcohol dehydrogenase
TthSNM33_08260	COG3191	aminopeptidase activity
TthSNM33_08270	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
TthSNM33_08280	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
TthSNM33_08290	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
TthSNM33_08310	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
TthSNM33_08330	COG0167	dihydroorotate dehydrogenase activity
TthSNM33_08360	COG0540	Belongs to the ATCase OTCase family
TthSNM33_08370	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
TthSNM33_08390	COG0730	response to heat
TthSNM33_08400	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
TthSNM33_08420	COG1960	acyl-CoA dehydrogenase activity
TthSNM33_08430	COG0456	acetyltransferase
TthSNM33_08450	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
TthSNM33_08460	COG0009	L-threonylcarbamoyladenylate synthase
TthSNM33_08470	COG1459	type II secretion system
TthSNM33_08500	COG0277	FAD linked oxidase domain protein
TthSNM33_08540	COG0287	Prephenate dehydrogenase
TthSNM33_08550	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
TthSNM33_08560	COG2514	catechol 2,3-dioxygenase activity
TthSNM33_08570	COG2353	YceI-like domain
TthSNM33_08580	COG1427	Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
TthSNM33_08590	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
TthSNM33_08620	COG1609	Transcriptional regulator
TthSNM33_08640	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
TthSNM33_08650	COG0179	Fumarylacetoacetate (FAA) hydrolase
TthSNM33_08670	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
TthSNM33_08680	COG0151	Belongs to the GarS family
TthSNM33_08690	COG2176	DNA-directed DNA polymerase activity
TthSNM33_08690	COG5002	protein histidine kinase activity
TthSNM33_08750	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
TthSNM33_08770	COG0217	transcriptional regulatory protein
TthSNM33_08790	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
TthSNM33_08790	COG4651	solute:proton antiporter activity
TthSNM33_08800	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
TthSNM33_08810	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
TthSNM33_08820	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
TthSNM33_08830	COG1674	ftsk spoiiie
TthSNM33_08860	COG0517	IMP dehydrogenase activity
TthSNM33_08880	COG3620	sequence-specific DNA binding
TthSNM33_08880	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
TthSNM33_08880	COG0617	tRNA 3'-terminal CCA addition
TthSNM33_08900	COG1994	Peptidase M50
TthSNM33_08910	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
TthSNM33_08930	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
TthSNM33_08960	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
TthSNM33_08980	COG2719	SpoVR family
TthSNM33_08990	COG2718	Belongs to the UPF0229 family
TthSNM33_09000	COG2766	serine protein kinase
TthSNM33_09050	COG2137	regulation of response to DNA damage stimulus
TthSNM33_09070	COG2359	stage V sporulation protein S
TthSNM33_09080	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
TthSNM33_09090	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
TthSNM33_09110	COG0463	Glycosyl transferase, family 2
TthSNM33_09120	COG0750	zinc metalloprotease
TthSNM33_09130	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
TthSNM33_09140	COG4589	Belongs to the CDS family
TthSNM33_09150	COG0233	cytoplasmic translational termination
TthSNM33_09160	COG0528	UMP kinase activity
TthSNM33_09170	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
TthSNM33_09180	COG0052	Belongs to the universal ribosomal protein uS2 family
TthSNM33_09190	COG0582	viral genome integration into host DNA
TthSNM33_09360	COG2165	general secretion pathway protein
TthSNM33_09440	COG2801	Transposase and inactivated derivatives
TthSNM33_09520	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
TthSNM33_09530	COG1653	transport
TthSNM33_09540	COG1175	transmembrane transport
TthSNM33_09550	COG0395	ABC-type sugar transport system, permease component
TthSNM33_09560	COG1692	metallophosphoesterase
TthSNM33_09590	COG1136	(ABC) transporter
TthSNM33_09620	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
TthSNM33_09720	COG1607	acyl-coa hydrolase
TthSNM33_09810	COG2205	protein histidine kinase activity
TthSNM33_09840	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
TthSNM33_09860	COG2197	response regulator
TthSNM33_09870	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
TthSNM33_09990	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
TthSNM33_10000	COG0494	nUDIX hydrolase
TthSNM33_10080	COG0402	S-adenosylhomocysteine deaminase activity
TthSNM33_10100	COG4948	Mandelate Racemase Muconate Lactonizing
TthSNM33_10110	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
TthSNM33_10120	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
TthSNM33_10130	COG1811	Na channel or pump
TthSNM33_10140	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
TthSNM33_10140	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
TthSNM33_10170	COG1215	transferase activity, transferring glycosyl groups
TthSNM33_10190	COG1215	transferase activity, transferring glycosyl groups
TthSNM33_10210	COG0438	transferase activity, transferring glycosyl groups
TthSNM33_10220	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
TthSNM33_10250	COG1250	3-hydroxyacyl-CoA dehydrogenase
TthSNM33_10250	COG1024	Enoyl-CoA hydratase
TthSNM33_10260	COG0183	Belongs to the thiolase family
TthSNM33_10270	COG1960	acyl-CoA dehydrogenase activity
TthSNM33_10280	COG0215	cysteine-tRNA ligase activity
TthSNM33_10290	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
TthSNM33_10340	COG1196	nuclear chromosome segregation
TthSNM33_10370	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
TthSNM33_10380	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
TthSNM33_10380	COG3153	acetyltransferase
TthSNM33_10390	COG1268	BioY protein
TthSNM33_10410	COG0126	phosphoglycerate kinase activity
TthSNM33_10420	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
TthSNM33_10430	COG0824	Thioesterase
TthSNM33_10450	COG0557	exoribonuclease II activity
TthSNM33_10460	COG1355	regulation of microtubule-based process
TthSNM33_10470	COG0617	tRNA 3'-terminal CCA addition
TthSNM33_10470	COG1353	crispr-associated protein
TthSNM33_10480	COG0237	dephospho-CoA kinase activity
TthSNM33_10500	COG0742	ribosomal rna small subunit methyltransferase
TthSNM33_10510	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
TthSNM33_10520	COG0138	bifunctional purine biosynthesis protein purh
TthSNM33_10530	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
TthSNM33_10560	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
TthSNM33_10710	COG0149	triose-phosphate isomerase activity
TthSNM33_10720	COG3239	Fatty acid desaturase
TthSNM33_10730	COG1490	D-aminoacyl-tRNA deacylase activity
TthSNM33_10740	COG1307	EDD domain protein, DegV family
TthSNM33_10750	COG1307	EDD domain protein, DegV family
TthSNM33_10760	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
TthSNM33_10790	COG3769	mannosylglycerate metabolic process
TthSNM33_10810	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
TthSNM33_10830	COG1012	belongs to the aldehyde dehydrogenase family
TthSNM33_10840	COG2368	4-hydroxyphenylacetate
TthSNM33_10850	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
TthSNM33_10910	COG0410	ABC transporter
TthSNM33_10920	COG2050	protein possibly involved in aromatic compounds catabolism
TthSNM33_10930	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
TthSNM33_10940	COG1012	belongs to the aldehyde dehydrogenase family
TthSNM33_10940	COG2030	dehydratase
TthSNM33_10980	COG3396	Phenylacetate-CoA oxygenase
TthSNM33_11000	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
TthSNM33_11020	COG0395	ABC-type sugar transport system, permease component
TthSNM33_11060	COG1980	fructose-bisphosphate aldolase activity
TthSNM33_11070	COG1733	regulation of RNA biosynthetic process
TthSNM33_11080	COG2193	ferroxidase activity
TthSNM33_11090	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
TthSNM33_11100	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
TthSNM33_11140	COG1331	Highly conserved protein containing a thioredoxin domain
TthSNM33_11150	COG0183	Belongs to the thiolase family
TthSNM33_11160	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
TthSNM33_11200	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
TthSNM33_11230	COG0745	RESPONSE REGULATOR receiver
TthSNM33_11240	COG1012	belongs to the aldehyde dehydrogenase family
TthSNM33_11260	COG0248	Ppx GppA phosphatase
TthSNM33_11270	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
TthSNM33_11280	COG0210	DNA helicase
TthSNM33_11330	COG0745	RESPONSE REGULATOR receiver
TthSNM33_11340	COG2205	protein histidine kinase activity
TthSNM33_11380	COG1136	(ABC) transporter
TthSNM33_11390	COG0577	efflux transmembrane transporter activity
TthSNM33_11390	COG1136	(ABC) transporter
TthSNM33_11440	COG3335	DDE superfamily endonuclease
TthSNM33_11520	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
TthSNM33_11560	COG3335	DDE superfamily endonuclease
TthSNM33_11640	COG0582	viral genome integration into host DNA
TthSNM33_11650	COG2897	thiosulfate sulfurtransferase activity
TthSNM33_11660	COG1760	l-serine dehydratase
TthSNM33_11670	COG2197	response regulator
TthSNM33_11680	COG0335	large ribosomal subunit rRNA binding
TthSNM33_11690	COG0336	Belongs to the RNA methyltransferase TrmD family
TthSNM33_11700	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
TthSNM33_11710	COG1837	Belongs to the UPF0109 family
TthSNM33_11720	COG0228	four-way junction DNA binding
TthSNM33_11750	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
TthSNM33_11760	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
TthSNM33_11760	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
TthSNM33_11770	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
TthSNM33_11790	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
TthSNM33_11810	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
TthSNM33_11820	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
TthSNM33_11830	COG1702	phosphate starvation-inducible protein PhoH
TthSNM33_11850	COG4864	UPF0365 protein
TthSNM33_11870	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
TthSNM33_11920	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
TthSNM33_11920	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
TthSNM33_11930	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
TthSNM33_11950	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
TthSNM33_11960	COG1397	ADP-ribosylglycohydrolase
TthSNM33_11970	COG2239	Acts as a magnesium transporter
TthSNM33_11980	COG2304	oxidoreductase activity
TthSNM33_11990	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
TthSNM33_11990	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
TthSNM33_12010	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
TthSNM33_12010	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
TthSNM33_12020	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
TthSNM33_12030	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
TthSNM33_12040	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
TthSNM33_12050	COG0006	proline dipeptidase activity
TthSNM33_12070	COG0739	heme binding
TthSNM33_12090	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
TthSNM33_12100	COG0254	rRNA binding
TthSNM33_12120	COG2001	Belongs to the MraZ family
TthSNM33_12130	COG0275	rRNA processing
TthSNM33_12150	COG0768	penicillin binding
TthSNM33_12160	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
TthSNM33_12180	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
TthSNM33_12190	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
TthSNM33_12200	COG0772	Belongs to the SEDS family
TthSNM33_12210	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
TthSNM33_12220	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
TthSNM33_12230	COG0812	UDP-N-acetylmuramate dehydrogenase activity
TthSNM33_12270	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
TthSNM33_12290	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
TthSNM33_12310	COG0159	tryptophan synthase activity
TthSNM33_12320	COG0133	tryptophan synthase activity
TthSNM33_12330	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
TthSNM33_12340	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
TthSNM33_12350	COG1744	ABC transporter substrate-binding protein PnrA-like
TthSNM33_12360	COG3845	ABC transporter
TthSNM33_12460	COG0438	transferase activity, transferring glycosyl groups
TthSNM33_12470	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
TthSNM33_12490	COG0039	L-malate dehydrogenase activity
TthSNM33_12500	COG2819	hydrolase of the alpha beta superfamily
TthSNM33_12530	COG0247	lactate metabolic process
TthSNM33_12530	COG2181	nitrate reductase activity
TthSNM33_12550	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
TthSNM33_12560	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
TthSNM33_12570	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
TthSNM33_12590	COG0439	Biotin carboxylase
TthSNM33_12600	COG0511	ligase activity, forming carbon-carbon bonds
TthSNM33_12610	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
TthSNM33_12650	COG0010	Belongs to the arginase family
TthSNM33_12680	COG1100	Small GTP-binding protein
TthSNM33_12700	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
TthSNM33_12710	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
TthSNM33_12730	COG2814	Major facilitator Superfamily
TthSNM33_12740	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
TthSNM33_12750	COG1185	polyribonucleotide nucleotidyltransferase activity
TthSNM33_12760	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
TthSNM33_12780	COG0745	RESPONSE REGULATOR receiver
TthSNM33_12790	COG5002	protein histidine kinase activity
TthSNM33_12800	COG1960	acyl-CoA dehydrogenase activity
TthSNM33_12810	COG2086	electron transfer activity
TthSNM33_12820	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
TthSNM33_12840	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
TthSNM33_12850	COG1573	uracil-dna glycosylase
TthSNM33_12860	COG1796	DNA polymerase
TthSNM33_12860	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
TthSNM33_12890	COG2309	aminopeptidase activity
TthSNM33_12930	COG2873	o-acetylhomoserine
TthSNM33_12940	COG2358	TRAP transporter, solute receptor (TAXI family
TthSNM33_12960	COG1126	abc transporter atp-binding protein
TthSNM33_13000	COG0134	indole-3-glycerol-phosphate synthase activity
TthSNM33_13010	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
TthSNM33_13030	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
TthSNM33_13060	COG0765	amino acid transport
TthSNM33_13070	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
TthSNM33_13090	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
TthSNM33_13100	COG0569	domain protein
TthSNM33_13110	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
TthSNM33_13120	COG1426	Protein conserved in bacteria
TthSNM33_13130	COG2313	pseudouridylate synthase activity
TthSNM33_13150	COG3001	Fructosamine kinase
TthSNM33_13160	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
TthSNM33_13180	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
TthSNM33_13210	COG0012	GTP binding
TthSNM33_13220	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
TthSNM33_13240	COG0424	maF-like protein
TthSNM33_13270	COG0768	penicillin binding
TthSNM33_13280	COG0850	regulation of cytokinetic process
TthSNM33_13290	COG2322	membrane
TthSNM33_13330	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
TthSNM33_13340	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
TthSNM33_13360	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
TthSNM33_13400	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
TthSNM33_13420	COG1131	(ABC) transporter
TthSNM33_13450	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
TthSNM33_13480	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
TthSNM33_13490	COG0440	acetolactate synthase activity
TthSNM33_13500	COG0028	Belongs to the TPP enzyme family
TthSNM33_13510	COG0492	ferredoxin-NADP+ reductase activity
TthSNM33_13520	COG4970	Tfp pilus assembly protein FimT
TthSNM33_13530	COG2165	general secretion pathway protein
TthSNM33_13540	COG4966	pilus assembly protein PilW
TthSNM33_13560	COG2165	general secretion pathway protein
TthSNM33_13650	COG0180	Tryptophanyl-tRNA synthetase
TthSNM33_13660	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
TthSNM33_13670	COG0066	3-isopropylmalate dehydratase activity
TthSNM33_13680	COG0473	3-isopropylmalate dehydrogenase activity
TthSNM33_13710	COG0300	oxidoreductase activity
TthSNM33_13720	COG0129	dihydroxy-acid dehydratase activity
TthSNM33_13740	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
TthSNM33_13750	COG1177	transmembrane transport
TthSNM33_13760	COG1176	ABC-type spermidine putrescine transport system, permease component I
TthSNM33_13770	COG3842	ATPase activity
TthSNM33_13780	COG0772	Belongs to the SEDS family
TthSNM33_13790	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
TthSNM33_13800	COG2894	cell division
TthSNM33_13810	COG1733	regulation of RNA biosynthetic process
TthSNM33_13830	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
TthSNM33_13830	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
TthSNM33_13850	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
TthSNM33_13860	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
TthSNM33_13870	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
TthSNM33_13880	COG0653	protein targeting
TthSNM33_13890	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
TthSNM33_13930	COG0393	Putative heavy-metal-binding
TthSNM33_13940	COG1111	helicase
TthSNM33_13940	COG1205	dead DEAH box helicase
TthSNM33_13970	COG0358	DNA primase activity
TthSNM33_13990	COG1250	3-hydroxyacyl-CoA dehydrogenase
TthSNM33_14000	COG0697	spore germination
TthSNM33_14010	COG0612	Peptidase, M16
TthSNM33_14020	COG0612	Peptidase, M16
TthSNM33_14030	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
TthSNM33_14060	COG1394	ATPase activity, coupled to movement of substances
TthSNM33_14070	COG1156	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit
TthSNM33_14080	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
TthSNM33_14090	COG1436	Produces ATP from ADP in the presence of a proton gradient across the membrane
TthSNM33_14100	COG1527	subunit (C
TthSNM33_14110	COG1390	Produces ATP from ADP in the presence of a proton gradient across the membrane
TthSNM33_14130	COG1269	ATP hydrolysis coupled proton transport
TthSNM33_14180	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
TthSNM33_14200	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
TthSNM33_14230	COG0419	ATPase involved in DNA repair
TthSNM33_14240	COG0420	3'-5' exonuclease activity
TthSNM33_14280	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
TthSNM33_14290	COG2884	Cell division ATP-binding protein ftsE
TthSNM33_14300	COG0793	Belongs to the peptidase S41A family
TthSNM33_14310	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
TthSNM33_14310	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
TthSNM33_14320	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
TthSNM33_14330	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
TthSNM33_14350	COG1079	Belongs to the binding-protein-dependent transport system permease family
TthSNM33_14360	COG4603	Belongs to the binding-protein-dependent transport system permease family
TthSNM33_14370	COG1129	ABC transporter
TthSNM33_14380	COG0746	molybdenum cofactor guanylyltransferase activity
TthSNM33_14400	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
TthSNM33_14440	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
TthSNM33_14450	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
TthSNM33_14470	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
TthSNM33_14490	COG0517	IMP dehydrogenase activity
TthSNM33_14490	COG1994	Peptidase M50
TthSNM33_14500	COG2358	TRAP transporter, solute receptor (TAXI family
TthSNM33_14530	COG2358	TRAP transporter, solute receptor (TAXI family
TthSNM33_14560	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
TthSNM33_14570	COG0788	formyltetrahydrofolate deformylase activity
TthSNM33_14580	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
TthSNM33_14590	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
TthSNM33_14600	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
TthSNM33_14640	COG0737	Belongs to the 5'-nucleotidase family
TthSNM33_14650	COG0174	glutamine synthetase
TthSNM33_14670	COG0559	Belongs to the binding-protein-dependent transport system permease family
TthSNM33_14710	COG0747	negative chemotaxis
TthSNM33_14720	COG0601	transmembrane transport
TthSNM33_14730	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
TthSNM33_14750	COG0285	dihydrofolate synthase activity
TthSNM33_14760	COG1132	(ABC) transporter
TthSNM33_14770	COG1132	(ABC) transporter
TthSNM33_14780	COG0372	Belongs to the citrate synthase family
TthSNM33_14790	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
TthSNM33_14800	COG1482	cell wall glycoprotein biosynthetic process
TthSNM33_14820	COG1515	deoxyribonuclease V activity
TthSNM33_14840	COG0776	regulation of translation
TthSNM33_14870	COG2197	response regulator
TthSNM33_14880	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
TthSNM33_14890	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
TthSNM33_14900	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
TthSNM33_14910	COG1324	tolerance protein
TthSNM33_14940	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
TthSNM33_14980	COG2205	protein histidine kinase activity
TthSNM33_15010	COG0247	lactate metabolic process
TthSNM33_15020	COG1139	Iron-sulfur cluster binding protein
TthSNM33_15030	COG1556	Lactate utilization protein
TthSNM33_15050	COG1752	Esterase of the alpha-beta hydrolase superfamily
TthSNM33_15060	COG0515	serine threonine protein kinase
TthSNM33_15060	COG2815	serine threonine protein kinase
TthSNM33_15080	COG0860	N-Acetylmuramoyl-L-alanine amidase
TthSNM33_15100	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
TthSNM33_15140	COG0473	3-isopropylmalate dehydrogenase activity
TthSNM33_15190	COG1450	Type ii and iii secretion system protein
TthSNM33_15200	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
TthSNM33_15210	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
TthSNM33_15220	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
TthSNM33_15230	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
TthSNM33_15230	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
TthSNM33_15240	COG0736	holo-[acyl-carrier-protein] synthase activity
TthSNM33_15290	COG1160	GTP binding
TthSNM33_15300	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
TthSNM33_15310	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
TthSNM33_15310	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
TthSNM33_15320	COG0083	homoserine kinase activity
TthSNM33_15340	COG0268	Binds directly to 16S ribosomal RNA
TthSNM33_15360	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
TthSNM33_15370	COG0723	plastoquinol--plastocyanin reductase activity
TthSNM33_15390	COG4235	cytochrome complex assembly
TthSNM33_15390	COG3088	subunit of a heme lyase
TthSNM33_15400	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
TthSNM33_15410	COG1138	Cytochrome C-type biogenesis protein
TthSNM33_15420	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
TthSNM33_15430	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
TthSNM33_15440	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
TthSNM33_15450	COG4133	protoheme IX ABC transporter activity
TthSNM33_15460	COG0785	Cytochrome C biogenesis protein
TthSNM33_15470	COG3258	Cytochrome c
TthSNM33_15490	COG0446	pyridine nucleotide-disulphide oxidoreductase
TthSNM33_15520	COG3258	Cytochrome c
TthSNM33_15530	COG2010	Cytochrome c
TthSNM33_15540	COG0737	Belongs to the 5'-nucleotidase family
TthSNM33_15550	COG2010	Cytochrome c
TthSNM33_15560	COG3258	Cytochrome c
TthSNM33_15600	COG2010	Cytochrome c
TthSNM33_15610	COG3842	ATPase activity
TthSNM33_15670	COG0318	PFAM AMP-dependent synthetase and ligase
TthSNM33_15680	COG3360	Dodecin
TthSNM33_15710	COG1024	Enoyl-CoA hydratase
TthSNM33_15720	COG0813	purine-nucleoside phosphorylase activity
TthSNM33_15730	COG1136	(ABC) transporter
TthSNM33_15740	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
TthSNM33_15750	COG2045	Belongs to the ComB family
TthSNM33_15770	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
TthSNM33_15790	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
TthSNM33_15810	COG0107	imidazoleglycerol-phosphate synthase activity
TthSNM33_15820	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
TthSNM33_15820	COG0140	phosphoribosyl-ATP diphosphatase activity
TthSNM33_15830	COG1494	fructose-1,6-bisphosphatase
TthSNM33_15840	COG0686	Belongs to the AlaDH PNT family
TthSNM33_15850	COG0427	acetyl-CoA hydrolase
TthSNM33_15860	COG0084	hydrolase, TatD family'
TthSNM33_15870	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
TthSNM33_15890	COG0017	Asparaginyl-tRNA synthetase
TthSNM33_15910	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
TthSNM33_15940	COG2009	succinate dehydrogenase
TthSNM33_15950	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
TthSNM33_16010	COG0318	PFAM AMP-dependent synthetase and ligase
TthSNM33_16020	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
TthSNM33_16030	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
TthSNM33_16040	COG0504	CTP synthase activity
TthSNM33_16060	COG0069	glutamate synthase activity
TthSNM33_16060	COG0070	glutamate synthase
TthSNM33_16060	COG0067	glutamate synthase
TthSNM33_16080	COG0840	transmembrane signaling receptor activity
TthSNM33_16090	COG0305	Participates in initiation and elongation during chromosome replication
TthSNM33_16110	COG0475	glutathione-regulated potassium exporter activity
TthSNM33_16120	COG0517	IMP dehydrogenase activity
TthSNM33_16120	COG0617	tRNA 3'-terminal CCA addition
TthSNM33_16120	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
TthSNM33_16150	COG0475	glutathione-regulated potassium exporter activity
TthSNM33_16160	COG0490	domain, Protein
TthSNM33_16200	COG3118	belongs to the thioredoxin family
TthSNM33_16260	COG0542	response to heat
TthSNM33_16270	COG0789	Transcriptional regulator
TthSNM33_16280	COG0484	heat shock protein binding
TthSNM33_16290	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
TthSNM33_16300	COG0443	Heat shock 70 kDa protein
TthSNM33_16310	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
TthSNM33_16320	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
TthSNM33_16330	COG0616	signal peptide processing
TthSNM33_16360	COG1310	metal-dependent protease of the Pad1 Jab1 superfamily
TthSNM33_16370	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
TthSNM33_16380	COG0714	Associated with various cellular activities
TthSNM33_16390	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
TthSNM33_16390	COG0574	Belongs to the PEP-utilizing enzyme family
TthSNM33_16400	COG1272	protein, Hemolysin III
TthSNM33_16420	COG5002	protein histidine kinase activity
TthSNM33_16420	COG3850	Histidine kinase
TthSNM33_16440	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
TthSNM33_16470	COG1011	Hydrolase
TthSNM33_16520	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
TthSNM33_16550	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
TthSNM33_16570	COG0047	phosphoribosylformylglycinamidine synthase activity
TthSNM33_16590	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
TthSNM33_16600	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
TthSNM33_16610	COG0116	Belongs to the methyltransferase superfamily
TthSNM33_16640	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
TthSNM33_16650	COG0497	DNA recombination
TthSNM33_16670	COG0604	alcohol dehydrogenase
TthSNM33_16710	COG0585	pseudouridine synthase activity
TthSNM33_16750	COG0557	exoribonuclease II activity
TthSNM33_16760	COG0538	isocitrate dehydrogenase activity
TthSNM33_16770	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
TthSNM33_16820	COG0037	tRNA processing
TthSNM33_16820	COG0590	tRNA wobble adenosine to inosine editing
TthSNM33_16870	COG2050	protein possibly involved in aromatic compounds catabolism
TthSNM33_16890	COG0322	excinuclease ABC activity
TthSNM33_16900	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
TthSNM33_16910	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
TthSNM33_16920	COG1854	S-ribosylhomocysteine lyase activity
TthSNM33_16930	COG0518	GMP synthase (glutamine-hydrolyzing) activity
TthSNM33_16930	COG0519	Catalyzes the synthesis of GMP from XMP
TthSNM33_16950	COG4274	PFAM GYD family protein
TthSNM33_16970	COG0328	RNA-DNA hybrid ribonuclease activity
TthSNM33_16980	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
TthSNM33_16990	COG2095	MarC family integral membrane protein
TthSNM33_17000	COG1438	arginine binding
TthSNM33_17010	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
TthSNM33_17020	COG1758	RNA polymerase activity
TthSNM33_17030	COG0194	GDP metabolic process
TthSNM33_17050	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
TthSNM33_17060	COG2385	sporulation resulting in formation of a cellular spore
TthSNM33_17070	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
TthSNM33_17090	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
TthSNM33_17150	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
TthSNM33_17160	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
TthSNM33_17170	COG1012	belongs to the aldehyde dehydrogenase family
TthSNM33_17180	COG0506	proline dehydrogenase activity
TthSNM33_17210	COG0156	8-amino-7-oxononanoate synthase activity
TthSNM33_17220	COG0732	type I restriction modification DNA specificity domain
TthSNM33_17220	COG0827	DNA restriction-modification system
TthSNM33_17250	COG0187	DNA topoisomerase II activity
TthSNM33_17260	COG1181	Belongs to the D-alanine--D-alanine ligase family
TthSNM33_17270	COG0193	aminoacyl-tRNA hydrolase activity
TthSNM33_17280	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
TthSNM33_17340	COG0515	serine threonine protein kinase
TthSNM33_17340	COG2815	serine threonine protein kinase
TthSNM33_17350	COG0631	protein serine/threonine phosphatase activity
TthSNM33_17380	COG0113	porphobilinogen synthase activity
TthSNM33_17390	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
TthSNM33_17400	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
TthSNM33_17450	COG4946	Tricorn protease homolog
TthSNM33_17450	COG1506	peptidase
TthSNM33_17450	COG0823	Involved in the tonB-independent uptake of proteins
TthSNM33_17460	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
TthSNM33_17470	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
TthSNM33_17510	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
TthSNM33_17520	COG1011	Hydrolase
TthSNM33_17580	COG0537	adenosine 5'-monophosphoramidase activity
TthSNM33_17590	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
TthSNM33_17600	COG0220	tRNA (guanine-N7-)-methyltransferase activity
TthSNM33_17610	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
TthSNM33_17620	COG0071	Belongs to the small heat shock protein (HSP20) family
TthSNM33_17630	COG2897	thiosulfate sulfurtransferase activity
TthSNM33_17640	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
TthSNM33_17660	COG1764	response to oxidative stress
TthSNM33_17710	COG3842	ATPase activity
TthSNM33_17720	COG0101	tRNA pseudouridine synthase activity
TthSNM33_17730	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
TthSNM33_17740	COG0601	transmembrane transport
TthSNM33_17770	COG0006	proline dipeptidase activity
TthSNM33_17780	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
TthSNM33_17810	COG1166	arginine decarboxylase activity
TthSNM33_17820	COG3706	GGDEF domain
TthSNM33_17830	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
TthSNM33_17840	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
TthSNM33_17850	COG1611	Belongs to the LOG family
TthSNM33_17860	COG1193	negative regulation of DNA recombination
TthSNM33_17880	COG0366	Alpha amylase catalytic
TthSNM33_17970	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
TthSNM33_17980	COG0142	geranyltranstransferase activity
TthSNM33_18000	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
TthSNM33_18060	COG0203	ribosomal protein L17
TthSNM33_18070	COG0202	RNA polymerase activity
TthSNM33_18080	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
TthSNM33_18090	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
TthSNM33_18100	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
TthSNM33_18110	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
TthSNM33_18130	COG0563	adenylate kinase activity
TthSNM33_18140	COG0201	protein transport
TthSNM33_18190	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
TthSNM33_18200	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
TthSNM33_18210	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
TthSNM33_18260	COG0255	Belongs to the universal ribosomal protein uL29 family
TthSNM33_18270	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
TthSNM33_18280	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
TthSNM33_18300	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
TthSNM33_18310	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
TthSNM33_18320	COG0089	rRNA binding
TthSNM33_18330	COG0088	Forms part of the polypeptide exit tunnel
TthSNM33_18350	COG0051	transcription antitermination factor activity, RNA binding
TthSNM33_18360	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
TthSNM33_18380	COG0049	tRNA binding
TthSNM33_18410	COG0442	prolyl-tRNA aminoacylation
TthSNM33_18450	COG1115	amino acid carrier protein
TthSNM33_18490	COG1489	DNA binding
TthSNM33_18520	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
TthSNM33_18560	COG0432	Pfam Uncharacterised protein family UPF0047
TthSNM33_18570	COG3253	May function as heme-dependent peroxidase
TthSNM33_18580	COG0668	transmembrane transport
TthSNM33_18600	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
TthSNM33_18610	COG2217	Heavy metal translocating P-type atpase
TthSNM33_18650	COG0745	RESPONSE REGULATOR receiver
TthSNM33_18660	COG2205	protein histidine kinase activity
TthSNM33_18710	COG2226	methyltransferase
TthSNM33_18750	COG2132	Multicopper oxidase
TthSNM33_18770	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
TthSNM33_18780	COG0822	iron-sulfur transferase activity
TthSNM33_18820	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
TthSNM33_18840	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
TthSNM33_18850	COG0284	orotidine-5'-phosphate decarboxylase activity
TthSNM33_18870	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
TthSNM33_18890	COG0416	fatty acid biosynthetic process
TthSNM33_18900	COG3118	belongs to the thioredoxin family
TthSNM33_18910	COG1185	polyribonucleotide nucleotidyltransferase activity
TthSNM33_18920	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
TthSNM33_18940	COG0438	transferase activity, transferring glycosyl groups
TthSNM33_18980	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
TthSNM33_19010	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
TthSNM33_19040	COG3706	GGDEF domain
TthSNM33_19110	COG0437	4 iron, 4 sulfur cluster binding
TthSNM33_19140	COG0825	malonyl-CoA metabolic process
TthSNM33_19150	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
TthSNM33_19230	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
TthSNM33_19280	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
TthSNM33_19290	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
TthSNM33_19300	COG0211	Belongs to the bacterial ribosomal protein bL27 family
TthSNM33_19310	COG0261	This protein binds to 23S rRNA in the presence of protein L20
TthSNM33_19390	COG0315	cyclic pyranopterin monophosphate synthase activity
TthSNM33_19410	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
TthSNM33_19440	COG1694	Mazg nucleotide pyrophosphohydrolase
TthSNM33_19450	COG1803	Methylglyoxal synthase
TthSNM33_19470	COG0301	tRNA thio-modification
TthSNM33_19480	COG0154	amidase activity
TthSNM33_19490	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
TthSNM33_19520	COG2154	pterin-4-alpha-carbinolamine dehydratase
TthSNM33_19530	COG1607	acyl-coa hydrolase
TthSNM33_19550	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
TthSNM33_19560	COG4149	molybdate abc transporter
TthSNM33_19570	COG1840	ABC-type Fe3 transport system, periplasmic component
TthSNM33_19600	COG0235	Class ii aldolase
TthSNM33_19610	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
TthSNM33_19620	COG0085	RNA polymerase activity
TthSNM33_19640	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
TthSNM33_19650	COG1077	Cell shape determining protein MreB Mrl
TthSNM33_19660	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
TthSNM33_19660	COG1418	mRNA catabolic process
TthSNM33_19670	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
TthSNM33_19680	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
TthSNM33_19690	COG1546	Belongs to the CinA family
TthSNM33_19690	COG1058	Belongs to the CinA family
TthSNM33_19700	COG0354	folic acid binding
TthSNM33_19820	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
TthSNM33_19840	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
TthSNM33_19860	COG0577	efflux transmembrane transporter activity
TthSNM33_19860	COG1136	(ABC) transporter
TthSNM33_19870	COG4181	ATPase activity
TthSNM33_19880	COG0446	pyridine nucleotide-disulphide oxidoreductase
TthSNM33_19910	COG0396	ATPase activity
TthSNM33_19920	COG0719	Fe-S assembly protein
TthSNM33_19930	COG0719	Fe-S assembly protein
TthSNM33_19940	COG2146	nitrite reductase [NAD(P)H] activity
TthSNM33_19960	COG0512	Glutamine amidotransferase of anthranilate synthase
TthSNM33_19970	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
TthSNM33_19990	COG2255	four-way junction helicase activity
TthSNM33_20030	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
TthSNM33_20040	COG2226	methyltransferase
TthSNM33_20050	COG4603	Belongs to the binding-protein-dependent transport system permease family
TthSNM33_20060	COG1079	Belongs to the binding-protein-dependent transport system permease family
TthSNM33_20100	COG1774	PSP1 C-terminal conserved region
TthSNM33_20110	COG0470	DNA polymerase III
TthSNM33_20180	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
TthSNM33_20210	COG0302	gtp cyclohydrolase
TthSNM33_20250	COG1217	gtp-binding protein TYPA
TthSNM33_20270	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
TthSNM33_20290	COG0395	ABC-type sugar transport system, permease component
TthSNM33_20300	COG1804	L-carnitine dehydratase bile acid-inducible protein F
TthSNM33_20310	COG1131	(ABC) transporter
TthSNM33_20350	COG0556	nucleotide-excision repair
TthSNM33_20360	COG0497	DNA recombination
TthSNM33_20370	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
TthSNM33_20380	COG0445	tRNA wobble uridine modification
TthSNM33_20430	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
TthSNM33_20430	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
TthSNM33_20440	COG1543	Belongs to the glycosyl hydrolase 57 family
TthSNM33_20450	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
TthSNM33_20460	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
TthSNM33_20490	COG0189	ligase activity
TthSNM33_20520	COG0066	3-isopropylmalate dehydratase activity
TthSNM33_20530	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
TthSNM33_20560	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
TthSNM33_20570	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
TthSNM33_20580	COG1960	acyl-CoA dehydrogenase activity
TthSNM33_20590	COG0163	prenyltransferase activity
TthSNM33_20640	COG1668	transmembrane transport
TthSNM33_20650	COG4555	ABC transporter
TthSNM33_20670	COG2096	Adenosyltransferase
TthSNM33_20700	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
TthSNM33_20710	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
TthSNM33_20740	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
TthSNM33_20750	COG0723	plastoquinol--plastocyanin reductase activity
TthSNM33_20770	COG2010	Cytochrome c
TthSNM33_20800	COG1653	transport
TthSNM33_20810	COG0820	rRNA (adenine-C2-)-methyltransferase activity
TthSNM33_20820	COG1960	acyl-CoA dehydrogenase activity
TthSNM33_20840	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
TthSNM33_20880	COG0393	Putative heavy-metal-binding
TthSNM33_20900	COG3956	TIGRFAM MazG family protein
TthSNM33_20920	COG0693	protein deglycase activity
TthSNM33_20930	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
TthSNM33_20950	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
TthSNM33_20960	COG1937	Protein conserved in bacteria
TthSNM33_20980	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
TthSNM33_20980	COG0674	pyruvate-flavodoxin oxidoreductase activity
TthSNM33_20990	COG1013	pyruvate-flavodoxin oxidoreductase activity
TthSNM33_21040	COG0205	6-phosphofructokinase activity
TthSNM33_21050	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
TthSNM33_21070	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
TthSNM33_21100	COG2333	competence protein COMEC
TthSNM33_21100	COG0658	competence protein
TthSNM33_21110	COG1475	DNA binding
TthSNM33_21120	COG1192	Involved in chromosome partitioning
TthSNM33_21130	COG0357	Ribosomal RNA small subunit methyltransferase G
TthSNM33_21150	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
TthSNM33_21180	COG1337	RAMP superfamily
TthSNM33_21230	COG3335	DDE superfamily endonuclease
TthSNM33_21250	COG1111	helicase
TthSNM33_21250	COG1205	dead DEAH box helicase
TthSNM33_21300	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
TthSNM33_21350	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
TthSNM33_21360	COG1518	maintenance of DNA repeat elements
TthSNM33_21460	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
TthSNM33_21470	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
TthSNM33_21600	COG2329	Antibiotic biosynthesis monooxygenase
TthSNM33_21660	COG4974	Belongs to the 'phage' integrase family
TthSNM33_21710	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
TthSNM33_21800	COG2329	Antibiotic biosynthesis monooxygenase
TthSNM33_21820	COG4558	Periplasmic binding protein
TthSNM33_21830	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
TthSNM33_21840	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
TthSNM33_21860	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
TthSNM33_22100	COG0588	phosphoglycerate mutase activity
TthSNM33_22140	COG1028	Short-chain dehydrogenase reductase Sdr
TthSNM33_22160	COG1012	belongs to the aldehyde dehydrogenase family
TthSNM33_22160	COG2030	dehydratase
TthSNM33_22170	COG1028	Short-chain dehydrogenase reductase Sdr
TthSNM33_22190	COG1960	acyl-CoA dehydrogenase activity
TthSNM33_22300	COG0739	heme binding
TthSNM33_22360	COG2211	Major facilitator Superfamily
TthSNM33_22380	COG1797	cobyrinic acid a,c-diamide synthase activity
TthSNM33_22410	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
TthSNM33_22440	COG0588	phosphoglycerate mutase activity
TthSNM33_22450	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
TthSNM33_22460	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
TthSNM33_22550	COG1648	precorrin-2 dehydrogenase activity
TthSNM33_22550	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
TthSNM33_22560	COG0778	Nitroreductase
TthSNM33_22600	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
TthSNM33_22630	COG1492	cobalamin metabolic process
TthSNM33_22640	COG1785	Belongs to the alkaline phosphatase family
TthSNM33_22670	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
TthSNM33_22690	COG0800	Aldolase
TthSNM33_22700	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
TthSNM33_22720	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
TthSNM33_22730	COG1028	Short-chain dehydrogenase reductase Sdr
TthSNM33_22760	COG1028	Short-chain dehydrogenase reductase Sdr
TthSNM33_22790	COG1175	transmembrane transport
TthSNM33_22820	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
TthSNM33_22860	COG1233	COG1233 Phytoene dehydrogenase and related
TthSNM33_22870	COG0702	epimerase
TthSNM33_22930	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
TthSNM33_22950	COG1562	ergosterol biosynthetic process
TthSNM33_22970	COG2124	cytochrome p450
TthSNM33_23020	COG1487	ribonuclease activity
TthSNM33_23040	COG1304	FMN binding
TthSNM33_23080	COG1085	galactose-1-phosphate uridylyltransferase
TthSNM33_23090	COG3345	alpha-galactosidase
TthSNM33_23140	COG4966	pilus assembly protein PilW
TthSNM33_23190	COG1475	DNA binding
TthSNM33_23200	COG1192	Involved in chromosome partitioning
TthSNM33_23320	COG0535	radical SAM domain protein
TthSNM33_23330	COG2010	Cytochrome c
TthSNM33_23370	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
TthSNM33_23510	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
TthSNM33_23520	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
TthSNM33_23530	COG1252	NADH dehydrogenase
TthSNM33_23570	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
TthSNM33_23590	COG2010	Cytochrome c
TthSNM33_23600	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
TthSNM33_23610	COG1140	nitrate reductase beta subunit
TthSNM33_23630	COG2181	nitrate reductase activity
TthSNM33_23710	COG2151	metal-sulfur cluster biosynthetic enzyme
TthSNM33_23720	COG2814	Major facilitator Superfamily
TthSNM33_23740	COG0584	glycerophosphoryl diester phosphodiesterase
TthSNM33_23760	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
TthSNM33_23770	COG0300	oxidoreductase activity
TthSNM33_23780	COG0673	inositol 2-dehydrogenase activity
TthSNM33_23800	COG1070	Carbohydrate kinase
TthSNM33_23830	COG1129	ABC transporter
TthSNM33_23840	COG4214	carbohydrate transport
TthSNM33_23850	COG4213	ABC transporter substrate-binding protein
TthSNM33_23910	COG1192	Involved in chromosome partitioning
TthSNM33_23920	COG1475	DNA binding
TthSNM33_24120	COG1203	CRISPR-associated helicase, Cas3
TthSNM33_24150	COG1074	ATP-dependent DNA helicase activity
TthSNM33_24230	COG1175	transmembrane transport
TthSNM33_24250	COG1028	Short-chain dehydrogenase reductase Sdr
TthSNM33_24280	COG1028	Short-chain dehydrogenase reductase Sdr
TthSNM33_24340	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
TthSNM33_24420	COG2002	toxin-antitoxin pair type II binding
TthSNM33_24560	COG1475	DNA binding
TthSNM33_24570	COG1192	Involved in chromosome partitioning
TthSNM33_24830	COG3854	ATPases associated with a variety of cellular activities
TthSNM33_24840	COG0497	DNA recombination
TthSNM33_24950	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
TthSNM33_25210	COG2205	protein histidine kinase activity
TthSNM33_25220	COG0745	RESPONSE REGULATOR receiver
TthSNM33_25230	COG2010	Cytochrome c
TthSNM33_25330	COG1175	transmembrane transport
TthSNM33_25400	COG1692	metallophosphoesterase
TthSNM33_25430	COG1175	transmembrane transport
TthSNM33_25440	COG0395	ABC-type sugar transport system, permease component
TthSNM33_t00360	COG0544	peptidyl-prolyl cis-trans isomerase activity