locus-tag	class	description
TthSNM66_00010	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
TthSNM66_00020	COG0592	DNA-directed DNA polymerase activity
TthSNM66_00030	COG0148	phosphopyruvate hydratase activity
TthSNM66_00040	COG0469	pyruvate kinase activity
TthSNM66_00060	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
TthSNM66_00070	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
TthSNM66_00090	COG1842	Phage shock protein A
TthSNM66_00130	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
TthSNM66_00140	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
TthSNM66_00160	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
TthSNM66_00170	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
TthSNM66_00180	COG1496	oxidoreductase activity
TthSNM66_00190	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
TthSNM66_00200	COG1278	Cold shock
TthSNM66_00210	COG1653	transport
TthSNM66_00240	COG0033	Phosphoglucomutase
TthSNM66_00280	COG0517	IMP dehydrogenase activity
TthSNM66_00280	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
TthSNM66_00290	COG1950	PFAM Membrane protein of
TthSNM66_00300	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
TthSNM66_00320	COG0181	hydroxymethylbilane synthase activity
TthSNM66_00340	COG0285	dihydrofolate synthase activity
TthSNM66_00350	COG0436	Aminotransferase
TthSNM66_00360	COG0521	Mo-molybdopterin cofactor biosynthetic process
TthSNM66_00410	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
TthSNM66_00420	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
TthSNM66_00430	COG1993	acr, cog1993
TthSNM66_00440	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
TthSNM66_00460	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
TthSNM66_00480	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
TthSNM66_00490	COG1335	isochorismatase
TthSNM66_00500	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
TthSNM66_00530	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
TthSNM66_00540	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
TthSNM66_00580	COG1660	Displays ATPase and GTPase activities
TthSNM66_00590	COG0391	Required for morphogenesis under gluconeogenic growth conditions
TthSNM66_00650	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
TthSNM66_00650	COG1845	cytochrome c oxidase, subunit III
TthSNM66_00660	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
TthSNM66_00660	COG2010	Cytochrome c
TthSNM66_00670	COG0109	protoheme IX farnesyltransferase activity
TthSNM66_00670	COG1612	heme a metabolic process
TthSNM66_00700	COG0343	queuine tRNA-ribosyltransferase activity
TthSNM66_00710	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
TthSNM66_00720	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
TthSNM66_00770	COG1940	carbohydrate kinase activity
TthSNM66_00790	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
TthSNM66_00800	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
TthSNM66_00810	COG0589	response to stress
TthSNM66_00820	COG1611	Belongs to the LOG family
TthSNM66_00840	COG1011	Hydrolase
TthSNM66_00850	COG0632	four-way junction helicase activity
TthSNM66_00860	COG1024	Enoyl-CoA hydratase
TthSNM66_00880	COG0508	dehydrogenase complex catalyzes the overall conversion of
TthSNM66_00930	COG0137	argininosuccinate synthase activity
TthSNM66_00940	COG0165	Argininosuccinate lyase
TthSNM66_00980	COG0505	Belongs to the CarA family
TthSNM66_00990	COG2759	Belongs to the formate--tetrahydrofolate ligase family
TthSNM66_01010	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
TthSNM66_01020	COG0166	Belongs to the GPI family
TthSNM66_01040	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
TthSNM66_01050	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
TthSNM66_01060	COG0459	protein refolding
TthSNM66_01070	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
TthSNM66_01080	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
TthSNM66_01100	COG0778	Nitroreductase
TthSNM66_01110	COG0791	NLP P60 protein
TthSNM66_01110	COG1388	LysM domain
TthSNM66_01130	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
TthSNM66_01150	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
TthSNM66_01160	COG0581	inorganic phosphate transmembrane transporter activity
TthSNM66_01170	COG0573	inorganic phosphate transmembrane transporter activity
TthSNM66_01180	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
TthSNM66_01190	COG0482	sulfurtransferase activity
TthSNM66_01210	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
TthSNM66_01220	COG0735	belongs to the Fur family
TthSNM66_01250	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
TthSNM66_01260	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
TthSNM66_01270	COG0267	Belongs to the bacterial ribosomal protein bL33 family
TthSNM66_01280	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
TthSNM66_01290	COG0250	Participates in transcription elongation, termination and antitermination
TthSNM66_01310	COG0081	regulation of translation
TthSNM66_01330	COG0629	single-stranded DNA binding
TthSNM66_01340	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
TthSNM66_01350	COG0359	binds to the 23S rRNA
TthSNM66_01370	COG0300	oxidoreductase activity
TthSNM66_01380	COG0321	lipoyl(octanoyl) transferase activity
TthSNM66_01390	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
TthSNM66_01420	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
TthSNM66_01450	COG1598	PFAM Uncharacterised protein family UPF0150
TthSNM66_01460	COG0022	dehydrogenase e1 component
TthSNM66_01470	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
TthSNM66_01480	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
TthSNM66_01530	COG2226	methyltransferase
TthSNM66_01540	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
TthSNM66_01560	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
TthSNM66_01570	COG1187	pseudouridine synthase activity
TthSNM66_01590	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
TthSNM66_01600	COG0686	Belongs to the AlaDH PNT family
TthSNM66_01620	COG1461	Dihydroxyacetone kinase
TthSNM66_01640	COG3583	domain protein
TthSNM66_01640	COG3584	3D domain protein
TthSNM66_01650	COG4591	ABC-type transport system involved in lipoprotein release permease component
TthSNM66_01660	COG0222	ribosome binding
TthSNM66_01670	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
TthSNM66_01690	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
TthSNM66_01720	COG0697	spore germination
TthSNM66_01740	COG3177	Filamentation induced by cAMP protein fic
TthSNM66_01760	COG0243	molybdopterin cofactor binding
TthSNM66_01770	COG2272	Belongs to the type-B carboxylesterase lipase family
TthSNM66_01780	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
TthSNM66_01800	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
TthSNM66_01830	COG0477	Major facilitator Superfamily
TthSNM66_01860	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
TthSNM66_01880	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
TthSNM66_01950	COG0508	dehydrogenase complex catalyzes the overall conversion of
TthSNM66_01970	COG0583	DNA-binding transcription factor activity
TthSNM66_01980	COG0631	protein serine/threonine phosphatase activity
TthSNM66_01990	COG0105	UTP biosynthetic process
TthSNM66_02020	COG3335	DDE superfamily endonuclease
TthSNM66_02050	COG1278	Cold shock
TthSNM66_02060	COG0484	heat shock protein binding
TthSNM66_02070	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
TthSNM66_02080	COG1968	undecaprenyl-diphosphatase activity
TthSNM66_02090	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
TthSNM66_02100	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
TthSNM66_02130	COG1309	transcriptional regulator
TthSNM66_02140	COG4242	Belongs to the peptidase S51 family
TthSNM66_02170	COG0802	atpase or kinase
TthSNM66_02180	COG0539	negative regulation of cytoplasmic translation
TthSNM66_02190	COG0495	leucyl-tRNA aminoacylation
TthSNM66_02230	COG3335	DDE superfamily endonuclease
TthSNM66_02320	COG0261	This protein binds to 23S rRNA in the presence of protein L20
TthSNM66_02330	COG0211	Belongs to the bacterial ribosomal protein bL27 family
TthSNM66_02340	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
TthSNM66_02350	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
TthSNM66_02400	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
TthSNM66_02470	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
TthSNM66_02480	COG0825	malonyl-CoA metabolic process
TthSNM66_02510	COG0437	4 iron, 4 sulfur cluster binding
TthSNM66_02580	COG3706	GGDEF domain
TthSNM66_02590	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
TthSNM66_02620	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
TthSNM66_02660	COG0438	transferase activity, transferring glycosyl groups
TthSNM66_02680	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
TthSNM66_02690	COG1185	polyribonucleotide nucleotidyltransferase activity
TthSNM66_02700	COG3118	belongs to the thioredoxin family
TthSNM66_02710	COG0416	fatty acid biosynthetic process
TthSNM66_02730	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
TthSNM66_02750	COG0284	orotidine-5'-phosphate decarboxylase activity
TthSNM66_02760	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
TthSNM66_02780	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
TthSNM66_02820	COG0822	iron-sulfur transferase activity
TthSNM66_02830	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
TthSNM66_02850	COG2132	Multicopper oxidase
TthSNM66_02890	COG2226	methyltransferase
TthSNM66_02940	COG2205	protein histidine kinase activity
TthSNM66_02950	COG0745	RESPONSE REGULATOR receiver
TthSNM66_02990	COG2217	Heavy metal translocating P-type atpase
TthSNM66_03000	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
TthSNM66_03020	COG0668	transmembrane transport
TthSNM66_03030	COG3253	May function as heme-dependent peroxidase
TthSNM66_03040	COG0432	Pfam Uncharacterised protein family UPF0047
TthSNM66_03080	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
TthSNM66_03110	COG1489	DNA binding
TthSNM66_03150	COG1115	amino acid carrier protein
TthSNM66_03190	COG0442	prolyl-tRNA aminoacylation
TthSNM66_03220	COG0049	tRNA binding
TthSNM66_03230	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
TthSNM66_03240	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
TthSNM66_03250	COG0051	transcription antitermination factor activity, RNA binding
TthSNM66_03270	COG0088	Forms part of the polypeptide exit tunnel
TthSNM66_03280	COG0089	rRNA binding
TthSNM66_03290	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
TthSNM66_03300	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
TthSNM66_03320	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
TthSNM66_03330	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
TthSNM66_03340	COG0255	Belongs to the universal ribosomal protein uL29 family
TthSNM66_03390	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
TthSNM66_03400	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
TthSNM66_03410	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
TthSNM66_03460	COG0201	protein transport
TthSNM66_03470	COG0563	adenylate kinase activity
TthSNM66_03490	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
TthSNM66_03500	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
TthSNM66_03510	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
TthSNM66_03520	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
TthSNM66_03530	COG0202	RNA polymerase activity
TthSNM66_03540	COG0203	ribosomal protein L17
TthSNM66_03600	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
TthSNM66_03630	COG0142	geranyltranstransferase activity
TthSNM66_03640	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
TthSNM66_03710	COG0366	Alpha amylase catalytic
TthSNM66_03730	COG1193	negative regulation of DNA recombination
TthSNM66_03740	COG1611	Belongs to the LOG family
TthSNM66_03750	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
TthSNM66_03760	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
TthSNM66_03770	COG3706	GGDEF domain
TthSNM66_03780	COG1166	arginine decarboxylase activity
TthSNM66_03810	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
TthSNM66_03820	COG0006	proline dipeptidase activity
TthSNM66_03850	COG0601	transmembrane transport
TthSNM66_03860	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
TthSNM66_03870	COG0101	tRNA pseudouridine synthase activity
TthSNM66_03880	COG3842	ATPase activity
TthSNM66_03900	COG1840	ABC-type Fe3 transport system, periplasmic component
TthSNM66_03930	COG1764	response to oxidative stress
TthSNM66_03950	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
TthSNM66_03960	COG2897	thiosulfate sulfurtransferase activity
TthSNM66_03970	COG0071	Belongs to the small heat shock protein (HSP20) family
TthSNM66_03980	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
TthSNM66_03990	COG0220	tRNA (guanine-N7-)-methyltransferase activity
TthSNM66_04000	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
TthSNM66_04010	COG0537	adenosine 5'-monophosphoramidase activity
TthSNM66_04060	COG1011	Hydrolase
TthSNM66_04070	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
TthSNM66_04110	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
TthSNM66_04120	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
TthSNM66_04130	COG4946	Tricorn protease homolog
TthSNM66_04130	COG0823	Involved in the tonB-independent uptake of proteins
TthSNM66_04130	COG1506	peptidase
TthSNM66_04180	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
TthSNM66_04190	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
TthSNM66_04200	COG0113	porphobilinogen synthase activity
TthSNM66_04230	COG0631	protein serine/threonine phosphatase activity
TthSNM66_04240	COG0515	serine threonine protein kinase
TthSNM66_04240	COG2815	serine threonine protein kinase
TthSNM66_04290	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
TthSNM66_04300	COG0193	aminoacyl-tRNA hydrolase activity
TthSNM66_04310	COG1181	Belongs to the D-alanine--D-alanine ligase family
TthSNM66_04320	COG0187	DNA topoisomerase II activity
TthSNM66_04350	COG0732	type I restriction modification DNA specificity domain
TthSNM66_04350	COG0827	DNA restriction-modification system
TthSNM66_04360	COG0156	8-amino-7-oxononanoate synthase activity
TthSNM66_04400	COG0506	proline dehydrogenase activity
TthSNM66_04410	COG1012	belongs to the aldehyde dehydrogenase family
TthSNM66_04420	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
TthSNM66_04430	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
TthSNM66_04510	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
TthSNM66_04530	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
TthSNM66_04540	COG2385	sporulation resulting in formation of a cellular spore
TthSNM66_04550	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
TthSNM66_04570	COG0194	GDP metabolic process
TthSNM66_04580	COG1758	RNA polymerase activity
TthSNM66_04590	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
TthSNM66_04600	COG1438	arginine binding
TthSNM66_04610	COG2095	MarC family integral membrane protein
TthSNM66_04620	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
TthSNM66_04630	COG0328	RNA-DNA hybrid ribonuclease activity
TthSNM66_04640	COG0346	lactoylglutathione lyase activity
TthSNM66_04650	COG4274	PFAM GYD family protein
TthSNM66_04660	COG4636	protein conserved in cyanobacteria
TthSNM66_04670	COG0518	GMP synthase (glutamine-hydrolyzing) activity
TthSNM66_04670	COG0519	Catalyzes the synthesis of GMP from XMP
TthSNM66_04680	COG1854	S-ribosylhomocysteine lyase activity
TthSNM66_04690	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
TthSNM66_04700	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
TthSNM66_04710	COG0322	excinuclease ABC activity
TthSNM66_04730	COG2050	protein possibly involved in aromatic compounds catabolism
TthSNM66_04770	COG0037	tRNA processing
TthSNM66_04770	COG0590	tRNA wobble adenosine to inosine editing
TthSNM66_04810	COG0538	isocitrate dehydrogenase activity
TthSNM66_04820	COG0557	exoribonuclease II activity
TthSNM66_04850	COG0585	pseudouridine synthase activity
TthSNM66_04890	COG0604	alcohol dehydrogenase
TthSNM66_04910	COG0497	DNA recombination
TthSNM66_04920	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
TthSNM66_04950	COG0116	Belongs to the methyltransferase superfamily
TthSNM66_04960	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
TthSNM66_04970	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
TthSNM66_04990	COG0047	phosphoribosylformylglycinamidine synthase activity
TthSNM66_05010	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
TthSNM66_05040	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
TthSNM66_05090	COG1011	Hydrolase
TthSNM66_05120	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
TthSNM66_05140	COG3850	Histidine kinase
TthSNM66_05140	COG5002	protein histidine kinase activity
TthSNM66_05160	COG1272	protein, Hemolysin III
TthSNM66_05170	COG0574	Belongs to the PEP-utilizing enzyme family
TthSNM66_05170	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
TthSNM66_05180	COG0714	Associated with various cellular activities
TthSNM66_05190	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
TthSNM66_05200	COG1310	metal-dependent protease of the Pad1 Jab1 superfamily
TthSNM66_05230	COG0616	signal peptide processing
TthSNM66_05240	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
TthSNM66_05250	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
TthSNM66_05260	COG0443	Heat shock 70 kDa protein
TthSNM66_05270	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
TthSNM66_05280	COG0484	heat shock protein binding
TthSNM66_05290	COG0789	Transcriptional regulator
TthSNM66_05300	COG0542	response to heat
TthSNM66_05360	COG3118	belongs to the thioredoxin family
TthSNM66_05400	COG0490	domain, Protein
TthSNM66_05410	COG0475	glutathione-regulated potassium exporter activity
TthSNM66_05440	COG1320	monovalent cation:proton antiporter activity
TthSNM66_05450	COG2212	antiporter activity
TthSNM66_05460	COG1863	multisubunit Na H antiporter MnhE subunit
TthSNM66_05470	COG0651	ATP synthesis coupled electron transport
TthSNM66_05480	COG1006	Multisubunit Na H antiporter MnhC subunit
TthSNM66_05490	COG2111	Na H antiporter
TthSNM66_05500	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
TthSNM66_05500	COG2111	Na H antiporter
TthSNM66_05540	COG0305	Participates in initiation and elongation during chromosome replication
TthSNM66_05550	COG0840	transmembrane signaling receptor activity
TthSNM66_05570	COG0070	glutamate synthase
TthSNM66_05570	COG0067	glutamate synthase
TthSNM66_05570	COG0069	glutamate synthase activity
TthSNM66_05590	COG0504	CTP synthase activity
TthSNM66_05600	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
TthSNM66_05610	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
TthSNM66_05620	COG0318	PFAM AMP-dependent synthetase and ligase
TthSNM66_05680	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
TthSNM66_05690	COG2009	succinate dehydrogenase
TthSNM66_05720	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
TthSNM66_05740	COG0017	Asparaginyl-tRNA synthetase
TthSNM66_05770	COG0084	hydrolase, TatD family'
TthSNM66_05780	COG0427	acetyl-CoA hydrolase
TthSNM66_05790	COG0686	Belongs to the AlaDH PNT family
TthSNM66_05800	COG1494	fructose-1,6-bisphosphatase
TthSNM66_05810	COG0140	phosphoribosyl-ATP diphosphatase activity
TthSNM66_05810	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
TthSNM66_05820	COG0107	imidazoleglycerol-phosphate synthase activity
TthSNM66_05840	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
TthSNM66_05860	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
TthSNM66_05880	COG2045	Belongs to the ComB family
TthSNM66_05890	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
TthSNM66_05900	COG1136	(ABC) transporter
TthSNM66_05910	COG0813	purine-nucleoside phosphorylase activity
TthSNM66_05920	COG1024	Enoyl-CoA hydratase
TthSNM66_05950	COG3360	Dodecin
TthSNM66_05960	COG0318	PFAM AMP-dependent synthetase and ligase
TthSNM66_06020	COG3842	ATPase activity
TthSNM66_06030	COG2010	Cytochrome c
TthSNM66_06070	COG3258	Cytochrome c
TthSNM66_06080	COG2010	Cytochrome c
TthSNM66_06090	COG0737	Belongs to the 5'-nucleotidase family
TthSNM66_06100	COG2010	Cytochrome c
TthSNM66_06110	COG3258	Cytochrome c
TthSNM66_06140	COG0446	pyridine nucleotide-disulphide oxidoreductase
TthSNM66_06160	COG3258	Cytochrome c
TthSNM66_06170	COG0785	Cytochrome C biogenesis protein
TthSNM66_06180	COG4133	protoheme IX ABC transporter activity
TthSNM66_06190	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
TthSNM66_06200	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
TthSNM66_06210	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
TthSNM66_06220	COG1138	Cytochrome C-type biogenesis protein
TthSNM66_06230	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
TthSNM66_06240	COG4235	cytochrome complex assembly
TthSNM66_06240	COG3088	subunit of a heme lyase
TthSNM66_06260	COG0723	plastoquinol--plastocyanin reductase activity
TthSNM66_06270	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
TthSNM66_06290	COG0268	Binds directly to 16S ribosomal RNA
TthSNM66_06310	COG0083	homoserine kinase activity
TthSNM66_06320	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
TthSNM66_06320	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
TthSNM66_06330	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
TthSNM66_06340	COG1160	GTP binding
TthSNM66_06370	COG0736	holo-[acyl-carrier-protein] synthase activity
TthSNM66_06380	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
TthSNM66_06380	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
TthSNM66_06390	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
TthSNM66_06400	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
TthSNM66_06410	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
TthSNM66_06420	COG1450	Type ii and iii secretion system protein
TthSNM66_06470	COG0473	3-isopropylmalate dehydrogenase activity
TthSNM66_06520	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
TthSNM66_06540	COG0860	N-Acetylmuramoyl-L-alanine amidase
TthSNM66_06560	COG0515	serine threonine protein kinase
TthSNM66_06560	COG2815	serine threonine protein kinase
TthSNM66_06570	COG1752	Esterase of the alpha-beta hydrolase superfamily
TthSNM66_06590	COG1556	Lactate utilization protein
TthSNM66_06600	COG1139	Iron-sulfur cluster binding protein
TthSNM66_06610	COG0247	lactate metabolic process
TthSNM66_06620	COG2205	protein histidine kinase activity
TthSNM66_06660	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
TthSNM66_06690	COG1324	tolerance protein
TthSNM66_06700	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
TthSNM66_06710	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
TthSNM66_06720	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
TthSNM66_06730	COG2197	response regulator
TthSNM66_06760	COG0776	regulation of translation
TthSNM66_06780	COG1515	deoxyribonuclease V activity
TthSNM66_06800	COG1482	cell wall glycoprotein biosynthetic process
TthSNM66_06810	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
TthSNM66_06820	COG0372	Belongs to the citrate synthase family
TthSNM66_06830	COG1132	(ABC) transporter
TthSNM66_06840	COG1132	(ABC) transporter
TthSNM66_06850	COG0285	dihydrofolate synthase activity
TthSNM66_06870	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
TthSNM66_06880	COG0601	transmembrane transport
TthSNM66_06890	COG0747	negative chemotaxis
TthSNM66_06930	COG0559	Belongs to the binding-protein-dependent transport system permease family
TthSNM66_06950	COG0174	glutamine synthetase
TthSNM66_06960	COG0737	Belongs to the 5'-nucleotidase family
TthSNM66_07000	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
TthSNM66_07010	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
TthSNM66_07020	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
TthSNM66_07030	COG0788	formyltetrahydrofolate deformylase activity
TthSNM66_07040	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
TthSNM66_07070	COG2358	TRAP transporter, solute receptor (TAXI family
TthSNM66_07090	COG2358	TRAP transporter, solute receptor (TAXI family
TthSNM66_07100	COG1994	Peptidase M50
TthSNM66_07100	COG0517	IMP dehydrogenase activity
TthSNM66_07120	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
TthSNM66_07130	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
TthSNM66_07140	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
TthSNM66_07180	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
TthSNM66_07200	COG0746	molybdenum cofactor guanylyltransferase activity
TthSNM66_07210	COG1129	ABC transporter
TthSNM66_07220	COG4603	Belongs to the binding-protein-dependent transport system permease family
TthSNM66_07230	COG1079	Belongs to the binding-protein-dependent transport system permease family
TthSNM66_07250	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
TthSNM66_07260	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
TthSNM66_07270	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
TthSNM66_07270	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
TthSNM66_07290	COG0793	Belongs to the peptidase S41A family
TthSNM66_07300	COG2884	Cell division ATP-binding protein ftsE
TthSNM66_07310	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
TthSNM66_07350	COG0420	3'-5' exonuclease activity
TthSNM66_07360	COG0419	ATPase involved in DNA repair
TthSNM66_07390	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
TthSNM66_07410	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
TthSNM66_07460	COG1269	ATP hydrolysis coupled proton transport
TthSNM66_07480	COG1390	Produces ATP from ADP in the presence of a proton gradient across the membrane
TthSNM66_07490	COG1527	subunit (C
TthSNM66_07500	COG1436	Produces ATP from ADP in the presence of a proton gradient across the membrane
TthSNM66_07510	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
TthSNM66_07520	COG1156	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit
TthSNM66_07530	COG1394	ATPase activity, coupled to movement of substances
TthSNM66_07560	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
TthSNM66_07570	COG0612	Peptidase, M16
TthSNM66_07580	COG0612	Peptidase, M16
TthSNM66_07590	COG1250	3-hydroxyacyl-CoA dehydrogenase
TthSNM66_07610	COG0358	DNA primase activity
TthSNM66_07640	COG1205	dead DEAH box helicase
TthSNM66_07640	COG1111	helicase
TthSNM66_07650	COG0393	Putative heavy-metal-binding
TthSNM66_07690	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
TthSNM66_07700	COG0653	protein targeting
TthSNM66_07710	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
TthSNM66_07720	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
TthSNM66_07730	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
TthSNM66_07750	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
TthSNM66_07750	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
TthSNM66_07770	COG1733	regulation of RNA biosynthetic process
TthSNM66_07780	COG2894	cell division
TthSNM66_07790	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
TthSNM66_07800	COG0772	Belongs to the SEDS family
TthSNM66_07810	COG3842	ATPase activity
TthSNM66_07820	COG1176	ABC-type spermidine putrescine transport system, permease component I
TthSNM66_07830	COG1177	transmembrane transport
TthSNM66_07840	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
TthSNM66_07860	COG0129	dihydroxy-acid dehydratase activity
TthSNM66_07870	COG0300	oxidoreductase activity
TthSNM66_07900	COG0473	3-isopropylmalate dehydrogenase activity
TthSNM66_07910	COG0066	3-isopropylmalate dehydratase activity
TthSNM66_07920	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
TthSNM66_07930	COG0180	Tryptophanyl-tRNA synthetase
TthSNM66_08010	COG2165	general secretion pathway protein
TthSNM66_08060	COG4970	Tfp pilus assembly protein FimT
TthSNM66_08070	COG0492	ferredoxin-NADP+ reductase activity
TthSNM66_08080	COG0028	Belongs to the TPP enzyme family
TthSNM66_08090	COG0440	acetolactate synthase activity
TthSNM66_08100	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
TthSNM66_08130	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
TthSNM66_08160	COG1131	(ABC) transporter
TthSNM66_08220	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
TthSNM66_08260	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
TthSNM66_08280	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
TthSNM66_08290	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
TthSNM66_08330	COG2322	membrane
TthSNM66_08340	COG0850	regulation of cytokinetic process
TthSNM66_08350	COG0768	penicillin binding
TthSNM66_08380	COG0424	maF-like protein
TthSNM66_08400	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
TthSNM66_08410	COG0012	GTP binding
TthSNM66_08440	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
TthSNM66_08460	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
TthSNM66_08470	COG3001	Fructosamine kinase
TthSNM66_08490	COG2313	pseudouridylate synthase activity
TthSNM66_08500	COG1426	Protein conserved in bacteria
TthSNM66_08510	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
TthSNM66_08520	COG0569	domain protein
TthSNM66_08530	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
TthSNM66_08550	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
TthSNM66_08560	COG0765	amino acid transport
TthSNM66_08590	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
TthSNM66_08610	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
TthSNM66_08620	COG0134	indole-3-glycerol-phosphate synthase activity
TthSNM66_08640	COG3311	Transcriptional regulator
TthSNM66_08650	COG1752	Esterase of the alpha-beta hydrolase superfamily
TthSNM66_08670	COG1126	abc transporter atp-binding protein
TthSNM66_08690	COG2358	TRAP transporter, solute receptor (TAXI family
TthSNM66_08700	COG2873	o-acetylhomoserine
TthSNM66_08740	COG2309	aminopeptidase activity
TthSNM66_08770	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
TthSNM66_08770	COG1796	DNA polymerase
TthSNM66_08780	COG1573	uracil-dna glycosylase
TthSNM66_08790	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
TthSNM66_08810	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
TthSNM66_08820	COG2086	electron transfer activity
TthSNM66_08830	COG1960	acyl-CoA dehydrogenase activity
TthSNM66_08840	COG5002	protein histidine kinase activity
TthSNM66_08850	COG0745	RESPONSE REGULATOR receiver
TthSNM66_08860	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
TthSNM66_08870	COG2239	Acts as a magnesium transporter
TthSNM66_08890	COG0589	response to stress
TthSNM66_08900	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
TthSNM66_08910	COG1185	polyribonucleotide nucleotidyltransferase activity
TthSNM66_08920	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
TthSNM66_08930	COG2814	Major facilitator Superfamily
TthSNM66_08950	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
TthSNM66_08960	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
TthSNM66_08980	COG1100	Small GTP-binding protein
TthSNM66_09010	COG0010	Belongs to the arginase family
TthSNM66_09050	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
TthSNM66_09060	COG0511	ligase activity, forming carbon-carbon bonds
TthSNM66_09070	COG0439	Biotin carboxylase
TthSNM66_09090	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
TthSNM66_09100	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
TthSNM66_09110	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
TthSNM66_09130	COG0247	lactate metabolic process
TthSNM66_09130	COG2181	nitrate reductase activity
TthSNM66_09160	COG2819	hydrolase of the alpha beta superfamily
TthSNM66_09170	COG0039	L-malate dehydrogenase activity
TthSNM66_09190	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
TthSNM66_09200	COG0438	transferase activity, transferring glycosyl groups
TthSNM66_09300	COG3845	ABC transporter
TthSNM66_09310	COG1744	ABC transporter substrate-binding protein PnrA-like
TthSNM66_09320	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
TthSNM66_09330	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
TthSNM66_09340	COG0133	tryptophan synthase activity
TthSNM66_09350	COG0159	tryptophan synthase activity
TthSNM66_09370	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
TthSNM66_09390	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
TthSNM66_09430	COG0812	UDP-N-acetylmuramate dehydrogenase activity
TthSNM66_09440	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
TthSNM66_09450	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
TthSNM66_09460	COG0772	Belongs to the SEDS family
TthSNM66_09470	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
TthSNM66_09480	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
TthSNM66_09500	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
TthSNM66_09510	COG0768	penicillin binding
TthSNM66_09530	COG0275	rRNA processing
TthSNM66_09540	COG2001	Belongs to the MraZ family
TthSNM66_09560	COG0254	rRNA binding
TthSNM66_09570	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
TthSNM66_09590	COG0739	heme binding
TthSNM66_09610	COG0006	proline dipeptidase activity
TthSNM66_09620	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
TthSNM66_09630	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
TthSNM66_09640	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
TthSNM66_09650	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
TthSNM66_09650	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
TthSNM66_09670	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
TthSNM66_09670	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
TthSNM66_09680	COG2304	oxidoreductase activity
TthSNM66_09690	COG2239	Acts as a magnesium transporter
TthSNM66_09700	COG1397	ADP-ribosylglycohydrolase
TthSNM66_09710	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
TthSNM66_09730	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
TthSNM66_09740	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
TthSNM66_09740	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
TthSNM66_09790	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
TthSNM66_09810	COG4864	UPF0365 protein
TthSNM66_09830	COG1702	phosphate starvation-inducible protein PhoH
TthSNM66_09840	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
TthSNM66_09850	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
TthSNM66_09870	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
TthSNM66_09890	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
TthSNM66_09900	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
TthSNM66_09900	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
TthSNM66_09910	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
TthSNM66_09940	COG0228	four-way junction DNA binding
TthSNM66_09950	COG1837	Belongs to the UPF0109 family
TthSNM66_09960	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
TthSNM66_09970	COG0336	Belongs to the RNA methyltransferase TrmD family
TthSNM66_09980	COG0335	large ribosomal subunit rRNA binding
TthSNM66_09990	COG2197	response regulator
TthSNM66_10000	COG1760	l-serine dehydratase
TthSNM66_10010	COG2897	thiosulfate sulfurtransferase activity
TthSNM66_10020	COG0582	viral genome integration into host DNA
TthSNM66_10070	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
TthSNM66_10160	COG1136	(ABC) transporter
TthSNM66_10160	COG0577	efflux transmembrane transporter activity
TthSNM66_10170	COG1136	(ABC) transporter
TthSNM66_10180	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
TthSNM66_10210	COG2205	protein histidine kinase activity
TthSNM66_10220	COG0745	RESPONSE REGULATOR receiver
TthSNM66_10270	COG0210	DNA helicase
TthSNM66_10280	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
TthSNM66_10290	COG0248	Ppx GppA phosphatase
TthSNM66_10310	COG1012	belongs to the aldehyde dehydrogenase family
TthSNM66_10320	COG0745	RESPONSE REGULATOR receiver
TthSNM66_10350	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
TthSNM66_10380	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
TthSNM66_10390	COG0183	Belongs to the thiolase family
TthSNM66_10400	COG1331	Highly conserved protein containing a thioredoxin domain
TthSNM66_10420	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
TthSNM66_10430	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
TthSNM66_10440	COG1733	regulation of RNA biosynthetic process
TthSNM66_10450	COG1980	fructose-bisphosphate aldolase activity
TthSNM66_10490	COG0395	ABC-type sugar transport system, permease component
TthSNM66_10510	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
TthSNM66_10530	COG3396	Phenylacetate-CoA oxygenase
TthSNM66_10570	COG1012	belongs to the aldehyde dehydrogenase family
TthSNM66_10570	COG2030	dehydratase
TthSNM66_10590	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
TthSNM66_10600	COG2050	protein possibly involved in aromatic compounds catabolism
TthSNM66_10610	COG0410	ABC transporter
TthSNM66_10660	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
TthSNM66_10670	COG2368	4-hydroxyphenylacetate
TthSNM66_10680	COG1012	belongs to the aldehyde dehydrogenase family
TthSNM66_10700	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
TthSNM66_10720	COG3769	mannosylglycerate metabolic process
TthSNM66_10750	COG1136	(ABC) transporter
TthSNM66_10790	COG1510	regulation of RNA biosynthetic process
TthSNM66_10800	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
TthSNM66_10810	COG1307	EDD domain protein, DegV family
TthSNM66_10820	COG1307	EDD domain protein, DegV family
TthSNM66_10830	COG1490	D-aminoacyl-tRNA deacylase activity
TthSNM66_10840	COG3239	Fatty acid desaturase
TthSNM66_10850	COG0149	triose-phosphate isomerase activity
TthSNM66_11040	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
TthSNM66_11070	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
TthSNM66_11080	COG0138	bifunctional purine biosynthesis protein purh
TthSNM66_11090	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
TthSNM66_11100	COG0742	ribosomal rna small subunit methyltransferase
TthSNM66_11120	COG0237	dephospho-CoA kinase activity
TthSNM66_11130	COG0617	tRNA 3'-terminal CCA addition
TthSNM66_11130	COG1353	crispr-associated protein
TthSNM66_11140	COG1355	regulation of microtubule-based process
TthSNM66_11150	COG0557	exoribonuclease II activity
TthSNM66_11170	COG0824	Thioesterase
TthSNM66_11180	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
TthSNM66_11190	COG0126	phosphoglycerate kinase activity
TthSNM66_11210	COG1268	BioY protein
TthSNM66_11220	COG3153	acetyltransferase
TthSNM66_11220	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
TthSNM66_11230	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
TthSNM66_11260	COG1196	nuclear chromosome segregation
TthSNM66_11290	COG2738	Putative neutral zinc metallopeptidase
TthSNM66_11310	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
TthSNM66_11320	COG0215	cysteine-tRNA ligase activity
TthSNM66_11330	COG1960	acyl-CoA dehydrogenase activity
TthSNM66_11340	COG0183	Belongs to the thiolase family
TthSNM66_11350	COG1024	Enoyl-CoA hydratase
TthSNM66_11350	COG1250	3-hydroxyacyl-CoA dehydrogenase
TthSNM66_11380	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
TthSNM66_11390	COG0438	transferase activity, transferring glycosyl groups
TthSNM66_11410	COG1215	transferase activity, transferring glycosyl groups
TthSNM66_11430	COG1215	transferase activity, transferring glycosyl groups
TthSNM66_11460	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
TthSNM66_11460	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
TthSNM66_11470	COG1811	Na channel or pump
TthSNM66_11480	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
TthSNM66_11490	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
TthSNM66_11500	COG4948	Mandelate Racemase Muconate Lactonizing
TthSNM66_11520	COG0402	S-adenosylhomocysteine deaminase activity
TthSNM66_11580	COG0494	nUDIX hydrolase
TthSNM66_11590	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
TthSNM66_11750	COG0582	viral genome integration into host DNA
TthSNM66_11760	COG0052	Belongs to the universal ribosomal protein uS2 family
TthSNM66_11770	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
TthSNM66_11780	COG0528	UMP kinase activity
TthSNM66_11790	COG0233	cytoplasmic translational termination
TthSNM66_11800	COG4589	Belongs to the CDS family
TthSNM66_11810	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
TthSNM66_11820	COG0750	zinc metalloprotease
TthSNM66_11830	COG0463	Glycosyl transferase, family 2
TthSNM66_11850	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
TthSNM66_11860	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
TthSNM66_11870	COG2359	stage V sporulation protein S
TthSNM66_11890	COG2137	regulation of response to DNA damage stimulus
TthSNM66_11940	COG2766	serine protein kinase
TthSNM66_11950	COG2718	Belongs to the UPF0229 family
TthSNM66_11960	COG2719	SpoVR family
TthSNM66_11980	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
TthSNM66_12010	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
TthSNM66_12030	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
TthSNM66_12040	COG1994	Peptidase M50
TthSNM66_12060	COG0617	tRNA 3'-terminal CCA addition
TthSNM66_12060	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
TthSNM66_12060	COG3620	sequence-specific DNA binding
TthSNM66_12080	COG0517	IMP dehydrogenase activity
TthSNM66_12110	COG1674	ftsk spoiiie
TthSNM66_12120	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
TthSNM66_12130	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
TthSNM66_12140	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
TthSNM66_12150	COG4651	solute:proton antiporter activity
TthSNM66_12150	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
TthSNM66_12160	COG0217	transcriptional regulatory protein
TthSNM66_12180	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
TthSNM66_12240	COG2176	DNA-directed DNA polymerase activity
TthSNM66_12240	COG5002	protein histidine kinase activity
TthSNM66_12250	COG0151	Belongs to the GarS family
TthSNM66_12260	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
TthSNM66_12280	COG0179	Fumarylacetoacetate (FAA) hydrolase
TthSNM66_12290	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
TthSNM66_12330	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
TthSNM66_12340	COG1427	Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
TthSNM66_12350	COG2353	YceI-like domain
TthSNM66_12360	COG2514	catechol 2,3-dioxygenase activity
TthSNM66_12370	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
TthSNM66_12380	COG0287	Prephenate dehydrogenase
TthSNM66_12420	COG0277	FAD linked oxidase domain protein
TthSNM66_12450	COG1459	type II secretion system
TthSNM66_12460	COG0009	L-threonylcarbamoyladenylate synthase
TthSNM66_12470	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
TthSNM66_12490	COG0456	acetyltransferase
TthSNM66_12500	COG1960	acyl-CoA dehydrogenase activity
TthSNM66_12540	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
TthSNM66_12550	COG0730	response to heat
TthSNM66_12630	COG0167	dihydroorotate dehydrogenase activity
TthSNM66_12650	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
TthSNM66_12670	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
TthSNM66_12680	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
TthSNM66_12690	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
TthSNM66_12720	COG1063	alcohol dehydrogenase
TthSNM66_12750	COG2873	o-acetylhomoserine
TthSNM66_12760	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
TthSNM66_12790	COG1073	alpha beta
TthSNM66_12800	COG0405	Gamma-glutamyltransferase
TthSNM66_12850	COG1028	Short-chain dehydrogenase reductase Sdr
TthSNM66_12880	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
TthSNM66_12900	COG0481	GTPase activity
TthSNM66_12920	COG1760	l-serine dehydratase
TthSNM66_12940	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
TthSNM66_12960	COG0295	cytidine deaminase activity
TthSNM66_13050	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
TthSNM66_13060	COG1316	TRANSCRIPTIONal
TthSNM66_13080	COG0518	GMP synthase (glutamine-hydrolyzing) activity
TthSNM66_13080	COG0519	Catalyzes the synthesis of GMP from XMP
TthSNM66_13090	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
TthSNM66_13130	COG1573	uracil-dna glycosylase
TthSNM66_13170	COG3842	ATPase activity
TthSNM66_13190	COG0124	histidyl-tRNA synthetase
TthSNM66_13210	COG0384	phenazine biosynthesis protein PhzF
TthSNM66_13220	COG0561	phosphatase activity
TthSNM66_13230	COG0017	Asparaginyl-tRNA synthetase
TthSNM66_13240	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
TthSNM66_13250	COG2217	Heavy metal translocating P-type atpase
TthSNM66_13260	COG0640	Transcriptional regulator
TthSNM66_13270	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
TthSNM66_13280	COG0739	heme binding
TthSNM66_13290	COG0779	Required for maturation of 30S ribosomal subunits
TthSNM66_13300	COG0195	Participates in both transcription termination and antitermination
TthSNM66_13320	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
TthSNM66_13340	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
TthSNM66_13340	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
TthSNM66_13370	COG0318	PFAM AMP-dependent synthetase and ligase
TthSNM66_13380	COG0596	Alpha beta hydrolase
TthSNM66_13400	COG2030	dehydratase
TthSNM66_13420	COG0559	Belongs to the binding-protein-dependent transport system permease family
TthSNM66_13460	COG1028	Short-chain dehydrogenase reductase Sdr
TthSNM66_13490	COG0183	Belongs to the thiolase family
TthSNM66_13500	COG1940	carbohydrate kinase activity
TthSNM66_13520	COG1175	transmembrane transport
TthSNM66_13580	COG0352	thiamine-phosphate diphosphorylase activity
TthSNM66_13580	COG0351	phosphomethylpyrimidine kinase
TthSNM66_13590	COG0477	Major facilitator Superfamily
TthSNM66_13600	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
TthSNM66_13610	COG2022	thiamine diphosphate biosynthetic process
TthSNM66_13610	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
TthSNM66_13620	COG2022	thiamine diphosphate biosynthetic process
TthSNM66_13630	COG2104	thiamine diphosphate biosynthetic process
TthSNM66_13640	COG0352	thiamine-phosphate diphosphorylase activity
TthSNM66_13660	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
TthSNM66_13670	COG1587	Uroporphyrinogen-III synthase
TthSNM66_13680	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
TthSNM66_13680	COG1648	precorrin-2 dehydrogenase activity
TthSNM66_13690	COG0175	sulfate reduction
TthSNM66_13700	COG0730	response to heat
TthSNM66_13710	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
TthSNM66_13710	COG1648	precorrin-2 dehydrogenase activity
TthSNM66_13720	COG2046	Belongs to the sulfate adenylyltransferase family
TthSNM66_13730	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
TthSNM66_13750	COG0574	Belongs to the PEP-utilizing enzyme family
TthSNM66_13750	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
TthSNM66_13810	COG1385	rRNA (uridine-N3-)-methyltransferase activity
TthSNM66_13820	COG2264	protein methyltransferase activity
TthSNM66_13840	COG0489	protein tyrosine kinase activity
TthSNM66_13880	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
TthSNM66_13910	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
TthSNM66_13980	COG0438	transferase activity, transferring glycosyl groups
TthSNM66_13990	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
TthSNM66_14000	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
TthSNM66_14010	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
TthSNM66_14130	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
TthSNM66_14140	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
TthSNM66_14160	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
TthSNM66_14170	COG1970	mechanosensitive ion channel activity
TthSNM66_14180	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
TthSNM66_14190	COG1692	metallophosphoesterase
TthSNM66_14240	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
TthSNM66_14260	COG1410	methionine synthase
TthSNM66_14260	COG0646	methionine synthase
TthSNM66_14270	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
TthSNM66_14280	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
TthSNM66_14290	COG0740	serine-type endopeptidase activity
TthSNM66_14300	COG0544	peptidyl-prolyl cis-trans isomerase activity
TthSNM66_14320	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
TthSNM66_14330	COG3870	Protein conserved in bacteria
TthSNM66_14350	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
TthSNM66_14360	COG1293	RNA-binding protein homologous to eukaryotic snRNP
TthSNM66_14370	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
TthSNM66_14400	COG1960	acyl-CoA dehydrogenase activity
TthSNM66_14410	COG2030	dehydratase
TthSNM66_14410	COG1012	belongs to the aldehyde dehydrogenase family
TthSNM66_14420	COG0318	PFAM AMP-dependent synthetase and ligase
TthSNM66_14440	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
TthSNM66_14450	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
TthSNM66_14460	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
TthSNM66_14470	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
TthSNM66_14500	COG0803	Belongs to the bacterial solute-binding protein 9 family
TthSNM66_14510	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
TthSNM66_14520	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
TthSNM66_14660	COG4475	Protein of unknown function (DUF436)
TthSNM66_14690	COG3842	ATPase activity
TthSNM66_14700	COG0572	uridine kinase
TthSNM66_14750	COG0154	amidase activity
TthSNM66_14760	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
TthSNM66_14780	COG2133	pyrroloquinoline quinone binding
TthSNM66_14790	COG1063	alcohol dehydrogenase
TthSNM66_14810	COG1254	Belongs to the acylphosphatase family
TthSNM66_14820	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
TthSNM66_14850	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
TthSNM66_14860	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
TthSNM66_14890	COG0183	Belongs to the thiolase family
TthSNM66_14900	COG0114	fumarate hydratase activity
TthSNM66_14910	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
TthSNM66_14920	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
TthSNM66_14930	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
TthSNM66_14950	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
TthSNM66_14970	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
TthSNM66_14990	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
TthSNM66_14990	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
TthSNM66_15030	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
TthSNM66_15060	COG0423	glycine-tRNA ligase activity
TthSNM66_15070	COG0542	response to heat
TthSNM66_15080	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
TthSNM66_15090	COG4956	integral membrane protein (PIN domain superfamily)
TthSNM66_15150	COG0527	aspartate kinase activity
TthSNM66_15160	COG2813	Specifically methylates the guanine in position
TthSNM66_15170	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
TthSNM66_15220	COG0196	riboflavin kinase activity
TthSNM66_15240	COG2197	response regulator
TthSNM66_15260	COG0243	molybdopterin cofactor binding
TthSNM66_15300	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
TthSNM66_15310	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
TthSNM66_15320	COG0509	glycine decarboxylation via glycine cleavage system
TthSNM66_15330	COG0404	The glycine cleavage system catalyzes the degradation of glycine
TthSNM66_15360	COG0281	malic enzyme
TthSNM66_15370	COG2151	metal-sulfur cluster biosynthetic enzyme
TthSNM66_15380	COG0861	Integral membrane protein TerC family
TthSNM66_15450	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
TthSNM66_15460	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
TthSNM66_15480	COG0789	Transcriptional regulator
TthSNM66_15490	COG1414	Transcriptional regulator
TthSNM66_15500	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
TthSNM66_15510	COG0277	FAD linked oxidase domain protein
TthSNM66_15530	COG0247	lactate metabolic process
TthSNM66_15590	COG0635	Involved in the biosynthesis of porphyrin-containing compound
TthSNM66_15650	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
TthSNM66_15670	COG0460	homoserine dehydrogenase
TthSNM66_15690	COG3744	PilT protein domain protein
TthSNM66_15700	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
TthSNM66_15720	COG0815	Transfers the fatty acyl group on membrane lipoproteins
TthSNM66_15730	COG2226	methyltransferase
TthSNM66_15740	COG2226	methyltransferase
TthSNM66_15750	COG0366	Alpha amylase catalytic
TthSNM66_15760	COG4175	Glycine betaine
TthSNM66_15760	COG3448	diguanylate cyclase activity
TthSNM66_15770	COG4176	ABC-type proline glycine betaine transport system permease component
TthSNM66_15790	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
TthSNM66_15820	COG0037	tRNA processing
TthSNM66_15830	COG2104	thiamine diphosphate biosynthetic process
TthSNM66_15840	COG0123	including yeast histone deacetylase and acetoin utilization protein
TthSNM66_15850	COG0617	tRNA 3'-terminal CCA addition
TthSNM66_15850	COG0517	IMP dehydrogenase activity
TthSNM66_15850	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
TthSNM66_15880	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
TthSNM66_15890	COG0601	transmembrane transport
TthSNM66_15900	COG0747	negative chemotaxis
TthSNM66_15930	COG0604	alcohol dehydrogenase
TthSNM66_15930	COG1028	Short-chain dehydrogenase reductase Sdr
TthSNM66_15930	COG3321	synthase
TthSNM66_15940	COG0492	ferredoxin-NADP+ reductase activity
TthSNM66_15980	COG1028	Short-chain dehydrogenase reductase Sdr
TthSNM66_16010	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
TthSNM66_16020	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
TthSNM66_16030	COG1104	cysteine desulfurase activity
TthSNM66_16040	COG1959	2 iron, 2 sulfur cluster binding
TthSNM66_16060	COG1108	ABC-type Mn2 Zn2 transport systems permease components
TthSNM66_16070	COG1121	(ABC) transporter
TthSNM66_16120	COG1022	Amp-dependent synthetase and ligase
TthSNM66_16170	COG0594	ribonuclease P activity
TthSNM66_16180	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
TthSNM66_16190	COG0706	membrane insertase activity
TthSNM66_16240	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
TthSNM66_16270	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
TthSNM66_16300	COG0517	IMP dehydrogenase activity
TthSNM66_16300	COG0516	GMP reductase activity
TthSNM66_16310	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
TthSNM66_16320	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
TthSNM66_16330	COG0131	Imidazoleglycerol-phosphate dehydratase
TthSNM66_16340	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
TthSNM66_16370	COG0778	Nitroreductase
TthSNM66_16440	COG0333	Belongs to the bacterial ribosomal protein bL32 family
TthSNM66_16450	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
TthSNM66_16460	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
TthSNM66_16480	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
TthSNM66_16490	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
TthSNM66_16500	COG0232	Belongs to the dGTPase family. Type 2 subfamily
TthSNM66_16510	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
TthSNM66_16540	COG0564	pseudouridine synthase activity
TthSNM66_16550	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
TthSNM66_16560	COG2255	four-way junction helicase activity
TthSNM66_16620	COG1063	alcohol dehydrogenase
TthSNM66_16720	COG3573	Dehydrogenase
TthSNM66_16740	COG1605	Chorismate mutase
TthSNM66_16740	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
TthSNM66_16750	COG0805	protein transport
TthSNM66_16760	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
TthSNM66_16770	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
TthSNM66_16780	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
TthSNM66_16840	COG0395	ABC-type sugar transport system, permease component
TthSNM66_16850	COG1175	transmembrane transport
TthSNM66_16880	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
TthSNM66_16890	COG0792	nuclease activity
TthSNM66_16910	COG0492	ferredoxin-NADP+ reductase activity
TthSNM66_16920	COG1028	Short-chain dehydrogenase reductase Sdr
TthSNM66_16930	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
TthSNM66_16950	COG0142	geranyltranstransferase activity
TthSNM66_16980	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
TthSNM66_16990	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
TthSNM66_17010	COG0297	glycogen (starch) synthase activity
TthSNM66_17020	COG2105	PFAM AIG2 family protein
TthSNM66_17030	COG0745	RESPONSE REGULATOR receiver
TthSNM66_17050	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
TthSNM66_17060	COG1067	ATP-dependent peptidase activity
TthSNM66_17140	COG0667	Aldo Keto reductase
TthSNM66_17150	COG0277	FAD linked oxidase domain protein
TthSNM66_17170	COG0227	Belongs to the bacterial ribosomal protein bL28 family
TthSNM66_17190	COG0569	domain protein
TthSNM66_17190	COG0475	glutathione-regulated potassium exporter activity
TthSNM66_17210	COG0436	Aminotransferase
TthSNM66_17220	COG1597	lipid kinase activity
TthSNM66_17250	COG0123	including yeast histone deacetylase and acetoin utilization protein
TthSNM66_17270	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
TthSNM66_17300	COG0347	Belongs to the P(II) protein family
TthSNM66_17310	COG1420	regulation of RNA biosynthetic process
TthSNM66_17320	COG0314	molybdopterin synthase activity
TthSNM66_17350	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
TthSNM66_17370	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
TthSNM66_17390	COG0277	FAD linked oxidase domain protein
TthSNM66_17450	COG1126	abc transporter atp-binding protein
TthSNM66_17460	COG2720	vancomycin resistance protein
TthSNM66_17480	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
TthSNM66_17490	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
TthSNM66_17490	COG1372	Participates in initiation and elongation during chromosome replication
TthSNM66_17500	COG0135	phosphoribosylanthranilate isomerase activity
TthSNM66_17530	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
TthSNM66_17560	COG4712	double-strand break repair protein
TthSNM66_17580	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
TthSNM66_17590	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
TthSNM66_17600	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
TthSNM66_17610	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
TthSNM66_17620	COG0649	NAD binding
TthSNM66_17630	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
TthSNM66_17640	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
TthSNM66_17650	COG1034	ATP synthesis coupled electron transport
TthSNM66_17660	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
TthSNM66_17670	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
TthSNM66_17680	COG0839	Belongs to the complex I subunit 6 family
TthSNM66_17690	COG0713	ATP synthesis coupled electron transport
TthSNM66_17700	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
TthSNM66_17710	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
TthSNM66_17720	COG1007	ATP synthesis coupled electron transport
TthSNM66_17730	COG0018	arginyl-trna synthetase
TthSNM66_17740	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
TthSNM66_17750	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
TthSNM66_17780	COG2070	2-Nitropropane dioxygenase
TthSNM66_17810	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
TthSNM66_17840	COG0513	Belongs to the DEAD box helicase family
TthSNM66_17890	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
TthSNM66_17900	COG0442	prolyl-tRNA aminoacylation
TthSNM66_17910	COG3635	2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity
TthSNM66_17930	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
TthSNM66_18460	COG1802	Transcriptional regulator
TthSNM66_18460	COG4626	Terminase
TthSNM66_18550	COG0582	viral genome integration into host DNA
TthSNM66_18570	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
TthSNM66_18580	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
TthSNM66_18580	COG0758	DNA mediated transformation
TthSNM66_18590	COG3546	catalase activity
TthSNM66_18600	COG0583	DNA-binding transcription factor activity
TthSNM66_18640	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
TthSNM66_18650	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
TthSNM66_18660	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
TthSNM66_18670	COG0717	Belongs to the dCTP deaminase family
TthSNM66_18700	COG0300	oxidoreductase activity
TthSNM66_18710	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
TthSNM66_18750	COG0515	serine threonine protein kinase
TthSNM66_18750	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
TthSNM66_18770	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
TthSNM66_18790	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
TthSNM66_18800	COG0704	Plays a role in the regulation of phosphate uptake
TthSNM66_18810	COG4191	Histidine kinase
TthSNM66_18820	COG0745	RESPONSE REGULATOR receiver
TthSNM66_18830	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
TthSNM66_18850	COG1187	pseudouridine synthase activity
TthSNM66_18870	COG1459	type II secretion system
TthSNM66_18930	COG2165	general secretion pathway protein
TthSNM66_18940	COG2165	general secretion pathway protein
TthSNM66_18960	COG2165	general secretion pathway protein
TthSNM66_18980	COG2414	aldehyde ferredoxin oxidoreductase
TthSNM66_19000	COG1902	pentaerythritol trinitrate reductase activity
TthSNM66_19110	COG0315	cyclic pyranopterin monophosphate synthase activity
TthSNM66_19130	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
TthSNM66_19160	COG0477	Major facilitator Superfamily
TthSNM66_19170	COG1694	Mazg nucleotide pyrophosphohydrolase
TthSNM66_19180	COG1803	Methylglyoxal synthase
TthSNM66_19200	COG0301	tRNA thio-modification
TthSNM66_19210	COG0154	amidase activity
TthSNM66_19220	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
TthSNM66_19250	COG2154	pterin-4-alpha-carbinolamine dehydratase
TthSNM66_19260	COG1607	acyl-coa hydrolase
TthSNM66_19280	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
TthSNM66_19290	COG4149	molybdate abc transporter
TthSNM66_19300	COG1840	ABC-type Fe3 transport system, periplasmic component
TthSNM66_19330	COG0235	Class ii aldolase
TthSNM66_19340	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
TthSNM66_19350	COG0085	RNA polymerase activity
TthSNM66_19370	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
TthSNM66_19380	COG1077	Cell shape determining protein MreB Mrl
TthSNM66_19390	COG1418	mRNA catabolic process
TthSNM66_19390	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
TthSNM66_19400	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
TthSNM66_19410	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
TthSNM66_19420	COG1058	Belongs to the CinA family
TthSNM66_19420	COG1546	Belongs to the CinA family
TthSNM66_19430	COG0354	folic acid binding
TthSNM66_19460	COG4948	Mandelate Racemase Muconate Lactonizing
TthSNM66_19490	COG1175	transmembrane transport
TthSNM66_19510	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
TthSNM66_19530	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
TthSNM66_19550	COG1136	(ABC) transporter
TthSNM66_19550	COG0577	efflux transmembrane transporter activity
TthSNM66_19560	COG4181	ATPase activity
TthSNM66_19570	COG0446	pyridine nucleotide-disulphide oxidoreductase
TthSNM66_19600	COG0396	ATPase activity
TthSNM66_19610	COG0719	Fe-S assembly protein
TthSNM66_19620	COG0719	Fe-S assembly protein
TthSNM66_19630	COG2146	nitrite reductase [NAD(P)H] activity
TthSNM66_19650	COG0512	Glutamine amidotransferase of anthranilate synthase
TthSNM66_19660	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
TthSNM66_19680	COG2255	four-way junction helicase activity
TthSNM66_19730	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
TthSNM66_19740	COG2226	methyltransferase
TthSNM66_19750	COG4603	Belongs to the binding-protein-dependent transport system permease family
TthSNM66_19760	COG1079	Belongs to the binding-protein-dependent transport system permease family
TthSNM66_19790	COG1774	PSP1 C-terminal conserved region
TthSNM66_19800	COG0470	DNA polymerase III
TthSNM66_19840	COG0497	DNA recombination
TthSNM66_19930	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
TthSNM66_19960	COG0302	gtp cyclohydrolase
TthSNM66_20010	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
TthSNM66_20030	COG0395	ABC-type sugar transport system, permease component
TthSNM66_20040	COG1804	L-carnitine dehydratase bile acid-inducible protein F
TthSNM66_20050	COG1131	(ABC) transporter
TthSNM66_20090	COG0556	nucleotide-excision repair
TthSNM66_20100	COG0497	DNA recombination
TthSNM66_20110	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
TthSNM66_20120	COG0445	tRNA wobble uridine modification
TthSNM66_20170	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
TthSNM66_20170	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
TthSNM66_20180	COG1543	Belongs to the glycosyl hydrolase 57 family
TthSNM66_20190	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
TthSNM66_20200	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
TthSNM66_20230	COG0189	ligase activity
TthSNM66_20260	COG0066	3-isopropylmalate dehydratase activity
TthSNM66_20270	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
TthSNM66_20300	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
TthSNM66_20310	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
TthSNM66_20320	COG1960	acyl-CoA dehydrogenase activity
TthSNM66_20330	COG0163	prenyltransferase activity
TthSNM66_20380	COG1668	transmembrane transport
TthSNM66_20390	COG4555	ABC transporter
TthSNM66_20410	COG2096	Adenosyltransferase
TthSNM66_20440	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
TthSNM66_20450	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
TthSNM66_20480	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
TthSNM66_20490	COG0723	plastoquinol--plastocyanin reductase activity
TthSNM66_20510	COG2010	Cytochrome c
TthSNM66_20540	COG1653	transport
TthSNM66_20550	COG0820	rRNA (adenine-C2-)-methyltransferase activity
TthSNM66_20560	COG1960	acyl-CoA dehydrogenase activity
TthSNM66_20580	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
TthSNM66_20620	COG0393	Putative heavy-metal-binding
TthSNM66_20640	COG3956	TIGRFAM MazG family protein
TthSNM66_20660	COG0693	protein deglycase activity
TthSNM66_20670	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
TthSNM66_20690	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
TthSNM66_20700	COG1937	Protein conserved in bacteria
TthSNM66_20720	COG0674	pyruvate-flavodoxin oxidoreductase activity
TthSNM66_20720	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
TthSNM66_20730	COG1013	pyruvate-flavodoxin oxidoreductase activity
TthSNM66_20740	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
TthSNM66_20780	COG0205	6-phosphofructokinase activity
TthSNM66_20790	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
TthSNM66_20810	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
TthSNM66_20840	COG0658	competence protein
TthSNM66_20840	COG2333	competence protein COMEC
TthSNM66_20850	COG1475	DNA binding
TthSNM66_20860	COG1192	Involved in chromosome partitioning
TthSNM66_20870	COG0357	Ribosomal RNA small subunit methyltransferase G
TthSNM66_20890	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
TthSNM66_20920	COG1492	cobalamin metabolic process
TthSNM66_20930	COG1785	Belongs to the alkaline phosphatase family
TthSNM66_20990	COG1414	Transcriptional regulator
TthSNM66_21000	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
TthSNM66_21020	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
TthSNM66_21030	COG1028	Short-chain dehydrogenase reductase Sdr
TthSNM66_21060	COG1028	Short-chain dehydrogenase reductase Sdr
TthSNM66_21100	COG2723	6-phospho-beta-galactosidase activity
TthSNM66_21110	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
TthSNM66_21140	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
TthSNM66_21160	COG1562	ergosterol biosynthetic process
TthSNM66_21180	COG2124	cytochrome p450
TthSNM66_21230	COG1487	ribonuclease activity
TthSNM66_21250	COG1304	FMN binding
TthSNM66_21290	COG1085	galactose-1-phosphate uridylyltransferase
TthSNM66_21300	COG3345	alpha-galactosidase
TthSNM66_21330	COG1475	DNA binding
TthSNM66_21350	COG1475	DNA binding
TthSNM66_21360	COG1192	Involved in chromosome partitioning
TthSNM66_21460	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
TthSNM66_21500	COG2132	Multicopper oxidase
TthSNM66_21510	COG0535	radical SAM domain protein
TthSNM66_21520	COG2010	Cytochrome c
TthSNM66_21560	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
TthSNM66_21680	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
TthSNM66_21690	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
TthSNM66_21700	COG1252	NADH dehydrogenase
TthSNM66_21740	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
TthSNM66_21760	COG2010	Cytochrome c
TthSNM66_21770	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
TthSNM66_21800	COG2181	nitrate reductase activity
TthSNM66_21880	COG2151	metal-sulfur cluster biosynthetic enzyme
TthSNM66_21890	COG2814	Major facilitator Superfamily
TthSNM66_21910	COG0584	glycerophosphoryl diester phosphodiesterase
TthSNM66_21930	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
TthSNM66_21950	COG2414	aldehyde ferredoxin oxidoreductase
TthSNM66_21970	COG1110	DNA topoisomerase II activity
TthSNM66_22010	COG0514	ATP-dependent DNA helicase (RecQ)
TthSNM66_22020	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
TthSNM66_22040	COG0747	negative chemotaxis
TthSNM66_22050	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
TthSNM66_22070	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
TthSNM66_22080	COG1012	belongs to the aldehyde dehydrogenase family
TthSNM66_22110	COG0395	ABC-type sugar transport system, permease component
TthSNM66_22120	COG1175	transmembrane transport
TthSNM66_22140	COG1609	Transcriptional regulator
TthSNM66_22210	COG0863	Belongs to the N(4) N(6)-methyltransferase family
TthSNM66_22260	COG1857	crispr-associated protein
TthSNM66_22300	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
TthSNM66_22320	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
TthSNM66_22330	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
TthSNM66_22400	COG2329	Antibiotic biosynthesis monooxygenase
TthSNM66_22450	COG4974	Belongs to the 'phage' integrase family
TthSNM66_22830	COG2211	Major facilitator Superfamily
TthSNM66_22870	COG2211	Major facilitator Superfamily
TthSNM66_22880	COG1797	cobyrinic acid a,c-diamide synthase activity
TthSNM66_22910	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
TthSNM66_22940	COG0588	phosphoglycerate mutase activity
TthSNM66_22950	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
TthSNM66_22960	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
TthSNM66_23050	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
TthSNM66_23050	COG1648	precorrin-2 dehydrogenase activity
TthSNM66_23060	COG0778	Nitroreductase
TthSNM66_23090	COG1175	transmembrane transport
TthSNM66_23160	COG2267	carboxylic ester hydrolase activity
TthSNM66_23240	COG1942	4-Oxalocrotonate Tautomerase
TthSNM66_23280	COG2084	Dehydrogenase
TthSNM66_23380	COG3335	DDE superfamily endonuclease
TthSNM66_23550	COG2002	toxin-antitoxin pair type II binding
TthSNM66_23630	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
TthSNM66_23730	COG3335	DDE superfamily endonuclease
TthSNM66_23850	COG1475	DNA binding
TthSNM66_23860	COG1192	Involved in chromosome partitioning
TthSNM66_23940	COG0395	ABC-type sugar transport system, permease component
TthSNM66_23950	COG1175	transmembrane transport
TthSNM66_23990	COG1692	metallophosphoesterase
TthSNM66_24220	COG4974	Belongs to the 'phage' integrase family
TthSNM66_t00240	COG0544	peptidyl-prolyl cis-trans isomerase activity