locus-tag	class	description
TthSNM76_00010	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
TthSNM76_00020	COG0592	DNA-directed DNA polymerase activity
TthSNM76_00030	COG0148	phosphopyruvate hydratase activity
TthSNM76_00040	COG0469	pyruvate kinase activity
TthSNM76_00060	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
TthSNM76_00070	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
TthSNM76_00090	COG1842	Phage shock protein A
TthSNM76_00120	COG0406	alpha-ribazole phosphatase activity
TthSNM76_00130	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
TthSNM76_00140	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
TthSNM76_00160	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
TthSNM76_00170	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
TthSNM76_00180	COG1496	oxidoreductase activity
TthSNM76_00190	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
TthSNM76_00200	COG1278	Cold shock
TthSNM76_00230	COG1653	transport
TthSNM76_00260	COG0033	Phosphoglucomutase
TthSNM76_00300	COG0517	IMP dehydrogenase activity
TthSNM76_00300	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
TthSNM76_00310	COG1950	PFAM Membrane protein of
TthSNM76_00320	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
TthSNM76_00340	COG0181	hydroxymethylbilane synthase activity
TthSNM76_00360	COG0285	dihydrofolate synthase activity
TthSNM76_00370	COG0436	Aminotransferase
TthSNM76_00380	COG0521	Mo-molybdopterin cofactor biosynthetic process
TthSNM76_00430	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
TthSNM76_00440	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
TthSNM76_00450	COG1993	acr, cog1993
TthSNM76_00460	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
TthSNM76_00480	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
TthSNM76_00500	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
TthSNM76_00510	COG1335	isochorismatase
TthSNM76_00520	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
TthSNM76_00550	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
TthSNM76_00560	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
TthSNM76_00600	COG1660	Displays ATPase and GTPase activities
TthSNM76_00610	COG0391	Required for morphogenesis under gluconeogenic growth conditions
TthSNM76_00670	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
TthSNM76_00670	COG1845	cytochrome c oxidase, subunit III
TthSNM76_00680	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
TthSNM76_00680	COG2010	Cytochrome c
TthSNM76_00690	COG0109	protoheme IX farnesyltransferase activity
TthSNM76_00690	COG1612	heme a metabolic process
TthSNM76_00720	COG0343	queuine tRNA-ribosyltransferase activity
TthSNM76_00730	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
TthSNM76_00740	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
TthSNM76_00790	COG1940	carbohydrate kinase activity
TthSNM76_00810	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
TthSNM76_00820	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
TthSNM76_00830	COG0589	response to stress
TthSNM76_00840	COG1611	Belongs to the LOG family
TthSNM76_00860	COG1011	Hydrolase
TthSNM76_00870	COG0632	four-way junction helicase activity
TthSNM76_00880	COG1024	Enoyl-CoA hydratase
TthSNM76_00910	COG0508	dehydrogenase complex catalyzes the overall conversion of
TthSNM76_00960	COG0137	argininosuccinate synthase activity
TthSNM76_00970	COG0165	Argininosuccinate lyase
TthSNM76_01010	COG0505	Belongs to the CarA family
TthSNM76_01030	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
TthSNM76_01040	COG0166	Belongs to the GPI family
TthSNM76_01060	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
TthSNM76_01070	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
TthSNM76_01080	COG0459	protein refolding
TthSNM76_01090	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
TthSNM76_01100	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
TthSNM76_01120	COG0778	Nitroreductase
TthSNM76_01130	COG0791	NLP P60 protein
TthSNM76_01130	COG1388	LysM domain
TthSNM76_01150	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
TthSNM76_01170	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
TthSNM76_01180	COG0581	inorganic phosphate transmembrane transporter activity
TthSNM76_01190	COG0573	inorganic phosphate transmembrane transporter activity
TthSNM76_01200	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
TthSNM76_01210	COG0482	sulfurtransferase activity
TthSNM76_01230	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
TthSNM76_01240	COG0735	belongs to the Fur family
TthSNM76_01270	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
TthSNM76_01280	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
TthSNM76_01290	COG0267	Belongs to the bacterial ribosomal protein bL33 family
TthSNM76_01300	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
TthSNM76_01310	COG0250	Participates in transcription elongation, termination and antitermination
TthSNM76_01330	COG0081	regulation of translation
TthSNM76_01350	COG0629	single-stranded DNA binding
TthSNM76_01360	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
TthSNM76_01370	COG0359	binds to the 23S rRNA
TthSNM76_01390	COG0300	oxidoreductase activity
TthSNM76_01400	COG0321	lipoyl(octanoyl) transferase activity
TthSNM76_01410	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
TthSNM76_01490	COG1476	TRANSCRIPTIONal
TthSNM76_01520	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
TthSNM76_01550	COG1598	PFAM Uncharacterised protein family UPF0150
TthSNM76_01560	COG0022	dehydrogenase e1 component
TthSNM76_01570	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
TthSNM76_01580	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
TthSNM76_01630	COG2226	methyltransferase
TthSNM76_01640	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
TthSNM76_01660	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
TthSNM76_01670	COG1187	pseudouridine synthase activity
TthSNM76_01690	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
TthSNM76_01700	COG0686	Belongs to the AlaDH PNT family
TthSNM76_01720	COG1461	Dihydroxyacetone kinase
TthSNM76_01740	COG3583	domain protein
TthSNM76_01740	COG3584	3D domain protein
TthSNM76_01750	COG4591	ABC-type transport system involved in lipoprotein release permease component
TthSNM76_01760	COG0222	ribosome binding
TthSNM76_01770	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
TthSNM76_01800	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
TthSNM76_01830	COG0697	spore germination
TthSNM76_01850	COG3177	Filamentation induced by cAMP protein fic
TthSNM76_01870	COG0243	molybdopterin cofactor binding
TthSNM76_01880	COG2272	Belongs to the type-B carboxylesterase lipase family
TthSNM76_01890	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
TthSNM76_01910	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
TthSNM76_01940	COG0477	Major facilitator Superfamily
TthSNM76_01970	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
TthSNM76_01990	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
TthSNM76_02060	COG0508	dehydrogenase complex catalyzes the overall conversion of
TthSNM76_02080	COG0583	DNA-binding transcription factor activity
TthSNM76_02090	COG0631	protein serine/threonine phosphatase activity
TthSNM76_02100	COG0105	UTP biosynthetic process
TthSNM76_02130	COG3335	DDE superfamily endonuclease
TthSNM76_02150	COG3335	DDE superfamily endonuclease
TthSNM76_02180	COG1278	Cold shock
TthSNM76_02190	COG0484	heat shock protein binding
TthSNM76_02200	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
TthSNM76_02210	COG1968	undecaprenyl-diphosphatase activity
TthSNM76_02220	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
TthSNM76_02230	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
TthSNM76_02260	COG1309	transcriptional regulator
TthSNM76_02270	COG4242	Belongs to the peptidase S51 family
TthSNM76_02300	COG0802	atpase or kinase
TthSNM76_02310	COG0539	negative regulation of cytoplasmic translation
TthSNM76_02320	COG0495	leucyl-tRNA aminoacylation
TthSNM76_02340	COG3335	DDE superfamily endonuclease
TthSNM76_02430	COG0261	This protein binds to 23S rRNA in the presence of protein L20
TthSNM76_02440	COG0211	Belongs to the bacterial ribosomal protein bL27 family
TthSNM76_02450	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
TthSNM76_02460	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
TthSNM76_02510	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
TthSNM76_02580	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
TthSNM76_02590	COG0825	malonyl-CoA metabolic process
TthSNM76_02620	COG0437	4 iron, 4 sulfur cluster binding
TthSNM76_02680	COG3706	GGDEF domain
TthSNM76_02690	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
TthSNM76_02720	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
TthSNM76_02760	COG0438	transferase activity, transferring glycosyl groups
TthSNM76_02780	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
TthSNM76_02790	COG1185	polyribonucleotide nucleotidyltransferase activity
TthSNM76_02800	COG3118	belongs to the thioredoxin family
TthSNM76_02810	COG0416	fatty acid biosynthetic process
TthSNM76_02830	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
TthSNM76_02850	COG0284	orotidine-5'-phosphate decarboxylase activity
TthSNM76_02860	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
TthSNM76_02880	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
TthSNM76_02920	COG0822	iron-sulfur transferase activity
TthSNM76_02930	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
TthSNM76_02950	COG2132	Multicopper oxidase
TthSNM76_02990	COG2226	methyltransferase
TthSNM76_03040	COG2205	protein histidine kinase activity
TthSNM76_03050	COG0745	RESPONSE REGULATOR receiver
TthSNM76_03090	COG2217	Heavy metal translocating P-type atpase
TthSNM76_03100	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
TthSNM76_03120	COG0668	transmembrane transport
TthSNM76_03130	COG3253	May function as heme-dependent peroxidase
TthSNM76_03140	COG0432	Pfam Uncharacterised protein family UPF0047
TthSNM76_03180	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
TthSNM76_03210	COG1489	DNA binding
TthSNM76_03250	COG1115	amino acid carrier protein
TthSNM76_03270	COG0442	prolyl-tRNA aminoacylation
TthSNM76_03300	COG0049	tRNA binding
TthSNM76_03320	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
TthSNM76_03330	COG0051	transcription antitermination factor activity, RNA binding
TthSNM76_03350	COG0088	Forms part of the polypeptide exit tunnel
TthSNM76_03360	COG0089	rRNA binding
TthSNM76_03370	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
TthSNM76_03380	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
TthSNM76_03400	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
TthSNM76_03410	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
TthSNM76_03420	COG0255	Belongs to the universal ribosomal protein uL29 family
TthSNM76_03470	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
TthSNM76_03480	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
TthSNM76_03490	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
TthSNM76_03540	COG0201	protein transport
TthSNM76_03550	COG0563	adenylate kinase activity
TthSNM76_03570	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
TthSNM76_03580	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
TthSNM76_03590	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
TthSNM76_03600	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
TthSNM76_03610	COG0202	RNA polymerase activity
TthSNM76_03620	COG0203	ribosomal protein L17
TthSNM76_03680	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
TthSNM76_03710	COG0142	geranyltranstransferase activity
TthSNM76_03720	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
TthSNM76_03790	COG0366	Alpha amylase catalytic
TthSNM76_03810	COG1193	negative regulation of DNA recombination
TthSNM76_03820	COG1611	Belongs to the LOG family
TthSNM76_03830	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
TthSNM76_03840	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
TthSNM76_03850	COG3706	GGDEF domain
TthSNM76_03860	COG1166	arginine decarboxylase activity
TthSNM76_03890	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
TthSNM76_03900	COG0006	proline dipeptidase activity
TthSNM76_03930	COG0601	transmembrane transport
TthSNM76_03940	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
TthSNM76_03950	COG0101	tRNA pseudouridine synthase activity
TthSNM76_03960	COG3842	ATPase activity
TthSNM76_03980	COG1840	ABC-type Fe3 transport system, periplasmic component
TthSNM76_04010	COG1764	response to oxidative stress
TthSNM76_04030	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
TthSNM76_04040	COG2897	thiosulfate sulfurtransferase activity
TthSNM76_04050	COG0071	Belongs to the small heat shock protein (HSP20) family
TthSNM76_04060	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
TthSNM76_04070	COG0220	tRNA (guanine-N7-)-methyltransferase activity
TthSNM76_04080	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
TthSNM76_04090	COG0537	adenosine 5'-monophosphoramidase activity
TthSNM76_04140	COG1011	Hydrolase
TthSNM76_04150	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
TthSNM76_04190	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
TthSNM76_04200	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
TthSNM76_04210	COG0823	Involved in the tonB-independent uptake of proteins
TthSNM76_04210	COG1506	peptidase
TthSNM76_04210	COG4946	Tricorn protease homolog
TthSNM76_04260	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
TthSNM76_04270	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
TthSNM76_04280	COG0113	porphobilinogen synthase activity
TthSNM76_04310	COG0631	protein serine/threonine phosphatase activity
TthSNM76_04320	COG0515	serine threonine protein kinase
TthSNM76_04320	COG2815	serine threonine protein kinase
TthSNM76_04380	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
TthSNM76_04390	COG0193	aminoacyl-tRNA hydrolase activity
TthSNM76_04400	COG1181	Belongs to the D-alanine--D-alanine ligase family
TthSNM76_04410	COG0187	DNA topoisomerase II activity
TthSNM76_04430	COG0732	type I restriction modification DNA specificity domain
TthSNM76_04430	COG0827	DNA restriction-modification system
TthSNM76_04440	COG0156	8-amino-7-oxononanoate synthase activity
TthSNM76_04470	COG0506	proline dehydrogenase activity
TthSNM76_04480	COG1012	belongs to the aldehyde dehydrogenase family
TthSNM76_04490	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
TthSNM76_04500	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
TthSNM76_04560	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
TthSNM76_04580	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
TthSNM76_04590	COG2385	sporulation resulting in formation of a cellular spore
TthSNM76_04600	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
TthSNM76_04620	COG0194	GDP metabolic process
TthSNM76_04630	COG1758	RNA polymerase activity
TthSNM76_04640	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
TthSNM76_04650	COG1438	arginine binding
TthSNM76_04660	COG2095	MarC family integral membrane protein
TthSNM76_04670	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
TthSNM76_04680	COG0328	RNA-DNA hybrid ribonuclease activity
TthSNM76_04700	COG4274	PFAM GYD family protein
TthSNM76_04720	COG0518	GMP synthase (glutamine-hydrolyzing) activity
TthSNM76_04720	COG0519	Catalyzes the synthesis of GMP from XMP
TthSNM76_04730	COG1854	S-ribosylhomocysteine lyase activity
TthSNM76_04740	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
TthSNM76_04750	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
TthSNM76_04760	COG0322	excinuclease ABC activity
TthSNM76_04780	COG2050	protein possibly involved in aromatic compounds catabolism
TthSNM76_04820	COG0590	tRNA wobble adenosine to inosine editing
TthSNM76_04820	COG0037	tRNA processing
TthSNM76_04850	COG4974	Belongs to the 'phage' integrase family
TthSNM76_04880	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
TthSNM76_04890	COG0538	isocitrate dehydrogenase activity
TthSNM76_04900	COG0557	exoribonuclease II activity
TthSNM76_04930	COG0585	pseudouridine synthase activity
TthSNM76_04970	COG0604	alcohol dehydrogenase
TthSNM76_04990	COG0497	DNA recombination
TthSNM76_05000	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
TthSNM76_05030	COG0116	Belongs to the methyltransferase superfamily
TthSNM76_05040	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
TthSNM76_05050	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
TthSNM76_05070	COG0047	phosphoribosylformylglycinamidine synthase activity
TthSNM76_05090	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
TthSNM76_05120	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
TthSNM76_05170	COG1011	Hydrolase
TthSNM76_05200	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
TthSNM76_05220	COG3850	Histidine kinase
TthSNM76_05220	COG5002	protein histidine kinase activity
TthSNM76_05240	COG1272	protein, Hemolysin III
TthSNM76_05250	COG0574	Belongs to the PEP-utilizing enzyme family
TthSNM76_05250	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
TthSNM76_05260	COG0714	Associated with various cellular activities
TthSNM76_05270	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
TthSNM76_05280	COG1310	metal-dependent protease of the Pad1 Jab1 superfamily
TthSNM76_05310	COG0616	signal peptide processing
TthSNM76_05320	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
TthSNM76_05330	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
TthSNM76_05340	COG0443	Heat shock 70 kDa protein
TthSNM76_05350	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
TthSNM76_05360	COG0484	heat shock protein binding
TthSNM76_05370	COG0789	Transcriptional regulator
TthSNM76_05380	COG0542	response to heat
TthSNM76_05440	COG3118	belongs to the thioredoxin family
TthSNM76_05480	COG0490	domain, Protein
TthSNM76_05490	COG0475	glutathione-regulated potassium exporter activity
TthSNM76_05520	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
TthSNM76_05520	COG0617	tRNA 3'-terminal CCA addition
TthSNM76_05520	COG0517	IMP dehydrogenase activity
TthSNM76_05530	COG0475	glutathione-regulated potassium exporter activity
TthSNM76_05550	COG0305	Participates in initiation and elongation during chromosome replication
TthSNM76_05560	COG0840	transmembrane signaling receptor activity
TthSNM76_05580	COG0069	glutamate synthase activity
TthSNM76_05580	COG0070	glutamate synthase
TthSNM76_05580	COG0067	glutamate synthase
TthSNM76_05600	COG0504	CTP synthase activity
TthSNM76_05610	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
TthSNM76_05620	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
TthSNM76_05630	COG0318	PFAM AMP-dependent synthetase and ligase
TthSNM76_05690	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
TthSNM76_05700	COG2009	succinate dehydrogenase
TthSNM76_05730	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
TthSNM76_05740	COG0017	Asparaginyl-tRNA synthetase
TthSNM76_05760	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
TthSNM76_05770	COG0084	hydrolase, TatD family'
TthSNM76_05780	COG0427	acetyl-CoA hydrolase
TthSNM76_05790	COG0686	Belongs to the AlaDH PNT family
TthSNM76_05800	COG1494	fructose-1,6-bisphosphatase
TthSNM76_05810	COG0140	phosphoribosyl-ATP diphosphatase activity
TthSNM76_05810	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
TthSNM76_05820	COG0107	imidazoleglycerol-phosphate synthase activity
TthSNM76_05840	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
TthSNM76_05870	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
TthSNM76_05890	COG2045	Belongs to the ComB family
TthSNM76_05900	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
TthSNM76_05910	COG1136	(ABC) transporter
TthSNM76_05920	COG0813	purine-nucleoside phosphorylase activity
TthSNM76_05930	COG1024	Enoyl-CoA hydratase
TthSNM76_05960	COG3360	Dodecin
TthSNM76_05970	COG0318	PFAM AMP-dependent synthetase and ligase
TthSNM76_06030	COG3842	ATPase activity
TthSNM76_06040	COG2010	Cytochrome c
TthSNM76_06080	COG3258	Cytochrome c
TthSNM76_06090	COG2010	Cytochrome c
TthSNM76_06100	COG0737	Belongs to the 5'-nucleotidase family
TthSNM76_06110	COG2010	Cytochrome c
TthSNM76_06120	COG3258	Cytochrome c
TthSNM76_06150	COG0446	pyridine nucleotide-disulphide oxidoreductase
TthSNM76_06170	COG3258	Cytochrome c
TthSNM76_06180	COG0785	Cytochrome C biogenesis protein
TthSNM76_06190	COG4133	protoheme IX ABC transporter activity
TthSNM76_06200	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
TthSNM76_06210	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
TthSNM76_06220	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
TthSNM76_06230	COG1138	Cytochrome C-type biogenesis protein
TthSNM76_06240	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
TthSNM76_06250	COG4235	cytochrome complex assembly
TthSNM76_06250	COG3088	subunit of a heme lyase
TthSNM76_06270	COG0723	plastoquinol--plastocyanin reductase activity
TthSNM76_06280	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
TthSNM76_06300	COG0268	Binds directly to 16S ribosomal RNA
TthSNM76_06320	COG0083	homoserine kinase activity
TthSNM76_06330	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
TthSNM76_06330	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
TthSNM76_06340	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
TthSNM76_06350	COG1160	GTP binding
TthSNM76_06380	COG0736	holo-[acyl-carrier-protein] synthase activity
TthSNM76_06390	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
TthSNM76_06390	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
TthSNM76_06400	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
TthSNM76_06410	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
TthSNM76_06420	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
TthSNM76_06430	COG1450	Type ii and iii secretion system protein
TthSNM76_06480	COG0473	3-isopropylmalate dehydrogenase activity
TthSNM76_06530	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
TthSNM76_06550	COG0860	N-Acetylmuramoyl-L-alanine amidase
TthSNM76_06570	COG0515	serine threonine protein kinase
TthSNM76_06570	COG2815	serine threonine protein kinase
TthSNM76_06580	COG1752	Esterase of the alpha-beta hydrolase superfamily
TthSNM76_06600	COG1556	Lactate utilization protein
TthSNM76_06610	COG1139	Iron-sulfur cluster binding protein
TthSNM76_06620	COG0247	lactate metabolic process
TthSNM76_06630	COG2205	protein histidine kinase activity
TthSNM76_06670	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
TthSNM76_06700	COG1324	tolerance protein
TthSNM76_06710	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
TthSNM76_06720	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
TthSNM76_06730	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
TthSNM76_06740	COG2197	response regulator
TthSNM76_06770	COG0776	regulation of translation
TthSNM76_06790	COG1515	deoxyribonuclease V activity
TthSNM76_06810	COG1482	cell wall glycoprotein biosynthetic process
TthSNM76_06820	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
TthSNM76_06830	COG0372	Belongs to the citrate synthase family
TthSNM76_06840	COG1132	(ABC) transporter
TthSNM76_06850	COG1132	(ABC) transporter
TthSNM76_06860	COG0285	dihydrofolate synthase activity
TthSNM76_06880	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
TthSNM76_06890	COG0601	transmembrane transport
TthSNM76_06900	COG0747	negative chemotaxis
TthSNM76_06940	COG0559	Belongs to the binding-protein-dependent transport system permease family
TthSNM76_06960	COG0174	glutamine synthetase
TthSNM76_06970	COG0737	Belongs to the 5'-nucleotidase family
TthSNM76_06990	COG2010	Cytochrome c
TthSNM76_07010	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
TthSNM76_07020	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
TthSNM76_07030	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
TthSNM76_07040	COG0788	formyltetrahydrofolate deformylase activity
TthSNM76_07050	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
TthSNM76_07080	COG2358	TRAP transporter, solute receptor (TAXI family
TthSNM76_07100	COG2358	TRAP transporter, solute receptor (TAXI family
TthSNM76_07110	COG1994	Peptidase M50
TthSNM76_07110	COG0517	IMP dehydrogenase activity
TthSNM76_07130	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
TthSNM76_07140	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
TthSNM76_07150	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
TthSNM76_07190	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
TthSNM76_07210	COG0746	molybdenum cofactor guanylyltransferase activity
TthSNM76_07220	COG1129	ABC transporter
TthSNM76_07230	COG4603	Belongs to the binding-protein-dependent transport system permease family
TthSNM76_07240	COG1079	Belongs to the binding-protein-dependent transport system permease family
TthSNM76_07260	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
TthSNM76_07270	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
TthSNM76_07280	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
TthSNM76_07280	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
TthSNM76_07300	COG0793	Belongs to the peptidase S41A family
TthSNM76_07310	COG2884	Cell division ATP-binding protein ftsE
TthSNM76_07320	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
TthSNM76_07360	COG0420	3'-5' exonuclease activity
TthSNM76_07370	COG0419	ATPase involved in DNA repair
TthSNM76_07400	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
TthSNM76_07420	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
TthSNM76_07470	COG1269	ATP hydrolysis coupled proton transport
TthSNM76_07490	COG1390	Produces ATP from ADP in the presence of a proton gradient across the membrane
TthSNM76_07500	COG1527	subunit (C
TthSNM76_07510	COG1436	Produces ATP from ADP in the presence of a proton gradient across the membrane
TthSNM76_07520	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
TthSNM76_07530	COG1156	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit
TthSNM76_07540	COG1394	ATPase activity, coupled to movement of substances
TthSNM76_07570	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
TthSNM76_07580	COG0612	Peptidase, M16
TthSNM76_07590	COG0612	Peptidase, M16
TthSNM76_07600	COG0697	spore germination
TthSNM76_07610	COG1250	3-hydroxyacyl-CoA dehydrogenase
TthSNM76_07630	COG0358	DNA primase activity
TthSNM76_07660	COG1111	helicase
TthSNM76_07660	COG1205	dead DEAH box helicase
TthSNM76_07670	COG0393	Putative heavy-metal-binding
TthSNM76_07680	COG0393	Putative heavy-metal-binding
TthSNM76_07720	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
TthSNM76_07730	COG0653	protein targeting
TthSNM76_07740	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
TthSNM76_07750	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
TthSNM76_07760	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
TthSNM76_07780	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
TthSNM76_07780	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
TthSNM76_07800	COG1733	regulation of RNA biosynthetic process
TthSNM76_07810	COG2894	cell division
TthSNM76_07820	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
TthSNM76_07830	COG0772	Belongs to the SEDS family
TthSNM76_07840	COG3842	ATPase activity
TthSNM76_07850	COG1176	ABC-type spermidine putrescine transport system, permease component I
TthSNM76_07860	COG1177	transmembrane transport
TthSNM76_07870	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
TthSNM76_07890	COG0129	dihydroxy-acid dehydratase activity
TthSNM76_07900	COG0300	oxidoreductase activity
TthSNM76_07930	COG0473	3-isopropylmalate dehydrogenase activity
TthSNM76_07940	COG0066	3-isopropylmalate dehydratase activity
TthSNM76_07950	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
TthSNM76_07960	COG0180	Tryptophanyl-tRNA synthetase
TthSNM76_08040	COG2165	general secretion pathway protein
TthSNM76_08090	COG4970	Tfp pilus assembly protein FimT
TthSNM76_08100	COG0492	ferredoxin-NADP+ reductase activity
TthSNM76_08110	COG0028	Belongs to the TPP enzyme family
TthSNM76_08120	COG0440	acetolactate synthase activity
TthSNM76_08130	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
TthSNM76_08160	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
TthSNM76_08190	COG1131	(ABC) transporter
TthSNM76_08210	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
TthSNM76_08240	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
TthSNM76_08260	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
TthSNM76_08270	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
TthSNM76_08310	COG2322	membrane
TthSNM76_08320	COG0850	regulation of cytokinetic process
TthSNM76_08330	COG0768	penicillin binding
TthSNM76_08360	COG0424	maF-like protein
TthSNM76_08380	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
TthSNM76_08390	COG0012	GTP binding
TthSNM76_08420	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
TthSNM76_08440	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
TthSNM76_08450	COG3001	Fructosamine kinase
TthSNM76_08470	COG2313	pseudouridylate synthase activity
TthSNM76_08480	COG1426	Protein conserved in bacteria
TthSNM76_08490	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
TthSNM76_08500	COG0569	domain protein
TthSNM76_08510	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
TthSNM76_08530	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
TthSNM76_08540	COG0765	amino acid transport
TthSNM76_08570	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
TthSNM76_08590	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
TthSNM76_08600	COG0134	indole-3-glycerol-phosphate synthase activity
TthSNM76_08620	COG3311	Transcriptional regulator
TthSNM76_08630	COG1752	Esterase of the alpha-beta hydrolase superfamily
TthSNM76_08650	COG1126	abc transporter atp-binding protein
TthSNM76_08670	COG2358	TRAP transporter, solute receptor (TAXI family
TthSNM76_08680	COG2873	o-acetylhomoserine
TthSNM76_08720	COG2309	aminopeptidase activity
TthSNM76_08750	COG1796	DNA polymerase
TthSNM76_08750	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
TthSNM76_08760	COG1573	uracil-dna glycosylase
TthSNM76_08770	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
TthSNM76_08790	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
TthSNM76_08800	COG2086	electron transfer activity
TthSNM76_08810	COG1960	acyl-CoA dehydrogenase activity
TthSNM76_08820	COG5002	protein histidine kinase activity
TthSNM76_08830	COG0745	RESPONSE REGULATOR receiver
TthSNM76_08840	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
TthSNM76_08850	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
TthSNM76_08860	COG1185	polyribonucleotide nucleotidyltransferase activity
TthSNM76_08870	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
TthSNM76_08880	COG2814	Major facilitator Superfamily
TthSNM76_08900	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
TthSNM76_08910	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
TthSNM76_08930	COG1100	Small GTP-binding protein
TthSNM76_08960	COG0010	Belongs to the arginase family
TthSNM76_09000	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
TthSNM76_09010	COG0511	ligase activity, forming carbon-carbon bonds
TthSNM76_09020	COG0439	Biotin carboxylase
TthSNM76_09040	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
TthSNM76_09050	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
TthSNM76_09060	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
TthSNM76_09080	COG0247	lactate metabolic process
TthSNM76_09080	COG2181	nitrate reductase activity
TthSNM76_09110	COG2819	hydrolase of the alpha beta superfamily
TthSNM76_09120	COG0039	L-malate dehydrogenase activity
TthSNM76_09140	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
TthSNM76_09150	COG0438	transferase activity, transferring glycosyl groups
TthSNM76_09250	COG3845	ABC transporter
TthSNM76_09260	COG1744	ABC transporter substrate-binding protein PnrA-like
TthSNM76_09270	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
TthSNM76_09280	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
TthSNM76_09290	COG0133	tryptophan synthase activity
TthSNM76_09300	COG0159	tryptophan synthase activity
TthSNM76_09320	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
TthSNM76_09340	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
TthSNM76_09380	COG0812	UDP-N-acetylmuramate dehydrogenase activity
TthSNM76_09390	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
TthSNM76_09400	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
TthSNM76_09410	COG0772	Belongs to the SEDS family
TthSNM76_09420	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
TthSNM76_09430	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
TthSNM76_09450	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
TthSNM76_09480	COG0275	rRNA processing
TthSNM76_09490	COG2001	Belongs to the MraZ family
TthSNM76_09510	COG0254	rRNA binding
TthSNM76_09520	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
TthSNM76_09540	COG0739	heme binding
TthSNM76_09560	COG0006	proline dipeptidase activity
TthSNM76_09570	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
TthSNM76_09580	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
TthSNM76_09590	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
TthSNM76_09600	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
TthSNM76_09600	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
TthSNM76_09620	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
TthSNM76_09620	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
TthSNM76_09630	COG2304	oxidoreductase activity
TthSNM76_09640	COG2239	Acts as a magnesium transporter
TthSNM76_09650	COG1397	ADP-ribosylglycohydrolase
TthSNM76_09660	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
TthSNM76_09680	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
TthSNM76_09690	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
TthSNM76_09690	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
TthSNM76_09740	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
TthSNM76_09760	COG4864	UPF0365 protein
TthSNM76_09780	COG1702	phosphate starvation-inducible protein PhoH
TthSNM76_09790	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
TthSNM76_09800	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
TthSNM76_09820	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
TthSNM76_09840	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
TthSNM76_09850	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
TthSNM76_09850	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
TthSNM76_09860	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
TthSNM76_09890	COG0228	four-way junction DNA binding
TthSNM76_09900	COG1837	Belongs to the UPF0109 family
TthSNM76_09910	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
TthSNM76_09920	COG0336	Belongs to the RNA methyltransferase TrmD family
TthSNM76_09930	COG0335	large ribosomal subunit rRNA binding
TthSNM76_09940	COG2197	response regulator
TthSNM76_09950	COG1760	l-serine dehydratase
TthSNM76_09960	COG2897	thiosulfate sulfurtransferase activity
TthSNM76_10010	COG0577	efflux transmembrane transporter activity
TthSNM76_10010	COG1136	(ABC) transporter
TthSNM76_10020	COG1136	(ABC) transporter
TthSNM76_10060	COG2205	protein histidine kinase activity
TthSNM76_10070	COG0745	RESPONSE REGULATOR receiver
TthSNM76_10120	COG0210	DNA helicase
TthSNM76_10150	COG1012	belongs to the aldehyde dehydrogenase family
TthSNM76_10160	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
TthSNM76_10160	COG2199	diguanylate cyclase activity
TthSNM76_10220	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
TthSNM76_10230	COG0183	Belongs to the thiolase family
TthSNM76_10240	COG1331	Highly conserved protein containing a thioredoxin domain
TthSNM76_10280	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
TthSNM76_10290	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
TthSNM76_10300	COG2193	ferroxidase activity
TthSNM76_10310	COG1733	regulation of RNA biosynthetic process
TthSNM76_10320	COG1980	fructose-bisphosphate aldolase activity
TthSNM76_10360	COG0395	ABC-type sugar transport system, permease component
TthSNM76_10380	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
TthSNM76_10400	COG3396	Phenylacetate-CoA oxygenase
TthSNM76_10440	COG1012	belongs to the aldehyde dehydrogenase family
TthSNM76_10440	COG2030	dehydratase
TthSNM76_10460	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
TthSNM76_10470	COG2050	protein possibly involved in aromatic compounds catabolism
TthSNM76_10480	COG0410	ABC transporter
TthSNM76_10530	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
TthSNM76_10540	COG2368	4-hydroxyphenylacetate
TthSNM76_10550	COG1012	belongs to the aldehyde dehydrogenase family
TthSNM76_10570	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
TthSNM76_10590	COG3769	mannosylglycerate metabolic process
TthSNM76_10620	COG1136	(ABC) transporter
TthSNM76_10660	COG1510	regulation of RNA biosynthetic process
TthSNM76_10670	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
TthSNM76_10680	COG1307	EDD domain protein, DegV family
TthSNM76_10690	COG1307	EDD domain protein, DegV family
TthSNM76_10700	COG1490	D-aminoacyl-tRNA deacylase activity
TthSNM76_10730	COG3239	Fatty acid desaturase
TthSNM76_10740	COG0149	triose-phosphate isomerase activity
TthSNM76_10940	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
TthSNM76_10970	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
TthSNM76_10980	COG0138	bifunctional purine biosynthesis protein purh
TthSNM76_10990	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
TthSNM76_11000	COG0742	ribosomal rna small subunit methyltransferase
TthSNM76_11020	COG0237	dephospho-CoA kinase activity
TthSNM76_11030	COG1353	crispr-associated protein
TthSNM76_11030	COG0617	tRNA 3'-terminal CCA addition
TthSNM76_11040	COG1355	regulation of microtubule-based process
TthSNM76_11050	COG0557	exoribonuclease II activity
TthSNM76_11070	COG0824	Thioesterase
TthSNM76_11080	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
TthSNM76_11090	COG0126	phosphoglycerate kinase activity
TthSNM76_11110	COG1268	BioY protein
TthSNM76_11120	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
TthSNM76_11120	COG3153	acetyltransferase
TthSNM76_11130	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
TthSNM76_11170	COG1196	nuclear chromosome segregation
TthSNM76_11200	COG2738	Putative neutral zinc metallopeptidase
TthSNM76_11220	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
TthSNM76_11230	COG0215	cysteine-tRNA ligase activity
TthSNM76_11240	COG1960	acyl-CoA dehydrogenase activity
TthSNM76_11250	COG0183	Belongs to the thiolase family
TthSNM76_11260	COG1024	Enoyl-CoA hydratase
TthSNM76_11260	COG1250	3-hydroxyacyl-CoA dehydrogenase
TthSNM76_11290	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
TthSNM76_11300	COG0438	transferase activity, transferring glycosyl groups
TthSNM76_11320	COG1215	transferase activity, transferring glycosyl groups
TthSNM76_11340	COG1215	transferase activity, transferring glycosyl groups
TthSNM76_11370	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
TthSNM76_11370	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
TthSNM76_11380	COG1811	Na channel or pump
TthSNM76_11390	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
TthSNM76_11400	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
TthSNM76_11410	COG4948	Mandelate Racemase Muconate Lactonizing
TthSNM76_11430	COG0402	S-adenosylhomocysteine deaminase activity
TthSNM76_11510	COG0494	nUDIX hydrolase
TthSNM76_11520	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
TthSNM76_11530	COG0052	Belongs to the universal ribosomal protein uS2 family
TthSNM76_11540	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
TthSNM76_11550	COG0528	UMP kinase activity
TthSNM76_11560	COG0233	cytoplasmic translational termination
TthSNM76_11570	COG4589	Belongs to the CDS family
TthSNM76_11580	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
TthSNM76_11590	COG0750	zinc metalloprotease
TthSNM76_11600	COG0463	Glycosyl transferase, family 2
TthSNM76_11620	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
TthSNM76_11630	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
TthSNM76_11640	COG2359	stage V sporulation protein S
TthSNM76_11660	COG2137	regulation of response to DNA damage stimulus
TthSNM76_11710	COG2766	serine protein kinase
TthSNM76_11720	COG2718	Belongs to the UPF0229 family
TthSNM76_11730	COG2719	SpoVR family
TthSNM76_11750	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
TthSNM76_11780	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
TthSNM76_11800	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
TthSNM76_11810	COG1994	Peptidase M50
TthSNM76_11830	COG0617	tRNA 3'-terminal CCA addition
TthSNM76_11830	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
TthSNM76_11830	COG3620	sequence-specific DNA binding
TthSNM76_11850	COG0517	IMP dehydrogenase activity
TthSNM76_11900	COG1674	ftsk spoiiie
TthSNM76_11910	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
TthSNM76_11920	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
TthSNM76_11930	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
TthSNM76_11940	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
TthSNM76_11940	COG4651	solute:proton antiporter activity
TthSNM76_11950	COG0217	transcriptional regulatory protein
TthSNM76_11970	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
TthSNM76_12030	COG5002	protein histidine kinase activity
TthSNM76_12030	COG2176	DNA-directed DNA polymerase activity
TthSNM76_12040	COG0151	Belongs to the GarS family
TthSNM76_12050	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
TthSNM76_12070	COG0179	Fumarylacetoacetate (FAA) hydrolase
TthSNM76_12080	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
TthSNM76_12120	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
TthSNM76_12130	COG1427	Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
TthSNM76_12140	COG2353	YceI-like domain
TthSNM76_12150	COG2514	catechol 2,3-dioxygenase activity
TthSNM76_12160	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
TthSNM76_12170	COG0287	Prephenate dehydrogenase
TthSNM76_12210	COG0277	FAD linked oxidase domain protein
TthSNM76_12240	COG1459	type II secretion system
TthSNM76_12250	COG0009	L-threonylcarbamoyladenylate synthase
TthSNM76_12260	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
TthSNM76_12280	COG0456	acetyltransferase
TthSNM76_12290	COG1960	acyl-CoA dehydrogenase activity
TthSNM76_12330	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
TthSNM76_12340	COG0730	response to heat
TthSNM76_12420	COG0167	dihydroorotate dehydrogenase activity
TthSNM76_12440	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
TthSNM76_12460	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
TthSNM76_12470	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
TthSNM76_12480	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
TthSNM76_12510	COG1063	alcohol dehydrogenase
TthSNM76_12540	COG2873	o-acetylhomoserine
TthSNM76_12550	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
TthSNM76_12580	COG1073	alpha beta
TthSNM76_12590	COG0405	Gamma-glutamyltransferase
TthSNM76_12640	COG1028	Short-chain dehydrogenase reductase Sdr
TthSNM76_12670	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
TthSNM76_12690	COG0481	GTPase activity
TthSNM76_12710	COG1760	l-serine dehydratase
TthSNM76_12720	COG1760	l-serine dehydratase
TthSNM76_12740	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
TthSNM76_12850	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
TthSNM76_12860	COG1316	TRANSCRIPTIONal
TthSNM76_12890	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
TthSNM76_12930	COG1573	uracil-dna glycosylase
TthSNM76_12970	COG3842	ATPase activity
TthSNM76_12990	COG0124	histidyl-tRNA synthetase
TthSNM76_13010	COG0384	phenazine biosynthesis protein PhzF
TthSNM76_13020	COG0561	phosphatase activity
TthSNM76_13030	COG0017	Asparaginyl-tRNA synthetase
TthSNM76_13040	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
TthSNM76_13050	COG2217	Heavy metal translocating P-type atpase
TthSNM76_13060	COG0640	Transcriptional regulator
TthSNM76_13070	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
TthSNM76_13080	COG0739	heme binding
TthSNM76_13090	COG0779	Required for maturation of 30S ribosomal subunits
TthSNM76_13100	COG0195	Participates in both transcription termination and antitermination
TthSNM76_13120	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
TthSNM76_13140	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
TthSNM76_13140	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
TthSNM76_13180	COG1028	Short-chain dehydrogenase reductase Sdr
TthSNM76_13210	COG0183	Belongs to the thiolase family
TthSNM76_13220	COG1940	carbohydrate kinase activity
TthSNM76_13260	COG1175	transmembrane transport
TthSNM76_13320	COG0351	phosphomethylpyrimidine kinase
TthSNM76_13320	COG0352	thiamine-phosphate diphosphorylase activity
TthSNM76_13330	COG0477	Major facilitator Superfamily
TthSNM76_13340	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
TthSNM76_13350	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
TthSNM76_13350	COG2022	thiamine diphosphate biosynthetic process
TthSNM76_13370	COG2022	thiamine diphosphate biosynthetic process
TthSNM76_13380	COG2104	thiamine diphosphate biosynthetic process
TthSNM76_13390	COG0352	thiamine-phosphate diphosphorylase activity
TthSNM76_13410	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
TthSNM76_13420	COG1587	Uroporphyrinogen-III synthase
TthSNM76_13430	COG1648	precorrin-2 dehydrogenase activity
TthSNM76_13430	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
TthSNM76_13440	COG0175	sulfate reduction
TthSNM76_13450	COG0730	response to heat
TthSNM76_13460	COG1648	precorrin-2 dehydrogenase activity
TthSNM76_13460	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
TthSNM76_13470	COG2046	Belongs to the sulfate adenylyltransferase family
TthSNM76_13480	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
TthSNM76_13500	COG0574	Belongs to the PEP-utilizing enzyme family
TthSNM76_13500	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
TthSNM76_13560	COG1385	rRNA (uridine-N3-)-methyltransferase activity
TthSNM76_13570	COG2264	protein methyltransferase activity
TthSNM76_13590	COG0489	protein tyrosine kinase activity
TthSNM76_13630	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
TthSNM76_13650	COG0438	transferase activity, transferring glycosyl groups
TthSNM76_13690	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
TthSNM76_13800	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
TthSNM76_13810	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
TthSNM76_13830	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
TthSNM76_13840	COG1970	mechanosensitive ion channel activity
TthSNM76_13850	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
TthSNM76_13860	COG1692	metallophosphoesterase
TthSNM76_13910	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
TthSNM76_13930	COG1410	methionine synthase
TthSNM76_13930	COG0646	methionine synthase
TthSNM76_13940	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
TthSNM76_13950	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
TthSNM76_13960	COG0740	serine-type endopeptidase activity
TthSNM76_13970	COG0544	peptidyl-prolyl cis-trans isomerase activity
TthSNM76_13990	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
TthSNM76_14000	COG3870	Protein conserved in bacteria
TthSNM76_14020	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
TthSNM76_14030	COG1293	RNA-binding protein homologous to eukaryotic snRNP
TthSNM76_14040	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
TthSNM76_14050	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
TthSNM76_14080	COG1960	acyl-CoA dehydrogenase activity
TthSNM76_14090	COG2030	dehydratase
TthSNM76_14090	COG1012	belongs to the aldehyde dehydrogenase family
TthSNM76_14100	COG0318	PFAM AMP-dependent synthetase and ligase
TthSNM76_14110	COG1028	Short-chain dehydrogenase reductase Sdr
TthSNM76_14130	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
TthSNM76_14140	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
TthSNM76_14150	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
TthSNM76_14190	COG0803	Belongs to the bacterial solute-binding protein 9 family
TthSNM76_14200	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
TthSNM76_14210	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
TthSNM76_14330	COG4475	Protein of unknown function (DUF436)
TthSNM76_14360	COG3842	ATPase activity
TthSNM76_14370	COG0572	uridine kinase
TthSNM76_14420	COG0154	amidase activity
TthSNM76_14430	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
TthSNM76_14450	COG2133	pyrroloquinoline quinone binding
TthSNM76_14460	COG1063	alcohol dehydrogenase
TthSNM76_14490	COG1254	Belongs to the acylphosphatase family
TthSNM76_14500	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
TthSNM76_14530	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
TthSNM76_14540	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
TthSNM76_14570	COG0183	Belongs to the thiolase family
TthSNM76_14580	COG0114	fumarate hydratase activity
TthSNM76_14590	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
TthSNM76_14600	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
TthSNM76_14610	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
TthSNM76_14630	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
TthSNM76_14650	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
TthSNM76_14670	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
TthSNM76_14670	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
TthSNM76_14710	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
TthSNM76_14740	COG0423	glycine-tRNA ligase activity
TthSNM76_14750	COG0542	response to heat
TthSNM76_14760	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
TthSNM76_14770	COG4956	integral membrane protein (PIN domain superfamily)
TthSNM76_14830	COG0527	aspartate kinase activity
TthSNM76_14840	COG2813	Specifically methylates the guanine in position
TthSNM76_14850	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
TthSNM76_14900	COG0196	riboflavin kinase activity
TthSNM76_14910	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
TthSNM76_14920	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
TthSNM76_14930	COG0509	glycine decarboxylation via glycine cleavage system
TthSNM76_14940	COG0404	The glycine cleavage system catalyzes the degradation of glycine
TthSNM76_14970	COG0281	malic enzyme
TthSNM76_14980	COG2151	metal-sulfur cluster biosynthetic enzyme
TthSNM76_14990	COG0861	Integral membrane protein TerC family
TthSNM76_15060	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
TthSNM76_15070	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
TthSNM76_15090	COG0789	Transcriptional regulator
TthSNM76_15100	COG1414	Transcriptional regulator
TthSNM76_15110	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
TthSNM76_15120	COG0277	FAD linked oxidase domain protein
TthSNM76_15130	COG0277	FAD linked oxidase domain protein
TthSNM76_15140	COG0247	lactate metabolic process
TthSNM76_15200	COG0635	Involved in the biosynthesis of porphyrin-containing compound
TthSNM76_15270	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
TthSNM76_15290	COG0460	homoserine dehydrogenase
TthSNM76_15310	COG3744	PilT protein domain protein
TthSNM76_15320	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
TthSNM76_15340	COG0815	Transfers the fatty acyl group on membrane lipoproteins
TthSNM76_15350	COG2226	methyltransferase
TthSNM76_15360	COG2226	methyltransferase
TthSNM76_15370	COG0366	Alpha amylase catalytic
TthSNM76_15380	COG4175	Glycine betaine
TthSNM76_15380	COG3448	diguanylate cyclase activity
TthSNM76_15390	COG4176	ABC-type proline glycine betaine transport system permease component
TthSNM76_15410	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
TthSNM76_15440	COG0037	tRNA processing
TthSNM76_15450	COG2104	thiamine diphosphate biosynthetic process
TthSNM76_15460	COG0123	including yeast histone deacetylase and acetoin utilization protein
TthSNM76_15470	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
TthSNM76_15470	COG0517	IMP dehydrogenase activity
TthSNM76_15470	COG0617	tRNA 3'-terminal CCA addition
TthSNM76_15500	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
TthSNM76_15510	COG0601	transmembrane transport
TthSNM76_15520	COG0747	negative chemotaxis
TthSNM76_15530	COG0604	alcohol dehydrogenase
TthSNM76_15530	COG1028	Short-chain dehydrogenase reductase Sdr
TthSNM76_15530	COG3321	synthase
TthSNM76_15540	COG0492	ferredoxin-NADP+ reductase activity
TthSNM76_15580	COG1028	Short-chain dehydrogenase reductase Sdr
TthSNM76_15610	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
TthSNM76_15620	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
TthSNM76_15630	COG1104	cysteine desulfurase activity
TthSNM76_15640	COG1959	2 iron, 2 sulfur cluster binding
TthSNM76_15650	COG1108	ABC-type Mn2 Zn2 transport systems permease components
TthSNM76_15660	COG1121	(ABC) transporter
TthSNM76_15710	COG1022	Amp-dependent synthetase and ligase
TthSNM76_15740	COG0594	ribonuclease P activity
TthSNM76_15750	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
TthSNM76_15760	COG0706	membrane insertase activity
TthSNM76_15810	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
TthSNM76_15840	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
TthSNM76_15870	COG0517	IMP dehydrogenase activity
TthSNM76_15870	COG0516	GMP reductase activity
TthSNM76_15880	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
TthSNM76_15890	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
TthSNM76_15900	COG0131	Imidazoleglycerol-phosphate dehydratase
TthSNM76_15910	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
TthSNM76_15940	COG0778	Nitroreductase
TthSNM76_16010	COG0333	Belongs to the bacterial ribosomal protein bL32 family
TthSNM76_16020	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
TthSNM76_16030	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
TthSNM76_16050	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
TthSNM76_16060	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
TthSNM76_16070	COG0232	Belongs to the dGTPase family. Type 2 subfamily
TthSNM76_16080	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
TthSNM76_16110	COG0564	pseudouridine synthase activity
TthSNM76_16120	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
TthSNM76_16130	COG2255	four-way junction helicase activity
TthSNM76_16190	COG1063	alcohol dehydrogenase
TthSNM76_16290	COG3573	Dehydrogenase
TthSNM76_16310	COG1605	Chorismate mutase
TthSNM76_16310	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
TthSNM76_16320	COG0805	protein transport
TthSNM76_16330	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
TthSNM76_16340	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
TthSNM76_16350	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
TthSNM76_16410	COG0395	ABC-type sugar transport system, permease component
TthSNM76_16420	COG1175	transmembrane transport
TthSNM76_16450	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
TthSNM76_16460	COG0792	nuclease activity
TthSNM76_16480	COG0492	ferredoxin-NADP+ reductase activity
TthSNM76_16490	COG1028	Short-chain dehydrogenase reductase Sdr
TthSNM76_16500	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
TthSNM76_16520	COG0142	geranyltranstransferase activity
TthSNM76_16550	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
TthSNM76_16560	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
TthSNM76_16580	COG0297	glycogen (starch) synthase activity
TthSNM76_16590	COG2105	PFAM AIG2 family protein
TthSNM76_16600	COG0745	RESPONSE REGULATOR receiver
TthSNM76_16620	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
TthSNM76_16630	COG1067	ATP-dependent peptidase activity
TthSNM76_16700	COG0667	Aldo Keto reductase
TthSNM76_16710	COG0277	FAD linked oxidase domain protein
TthSNM76_16730	COG0227	Belongs to the bacterial ribosomal protein bL28 family
TthSNM76_16750	COG0475	glutathione-regulated potassium exporter activity
TthSNM76_16750	COG0569	domain protein
TthSNM76_16770	COG0436	Aminotransferase
TthSNM76_16780	COG1597	lipid kinase activity
TthSNM76_16810	COG0123	including yeast histone deacetylase and acetoin utilization protein
TthSNM76_16830	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
TthSNM76_16860	COG0347	Belongs to the P(II) protein family
TthSNM76_16870	COG1420	regulation of RNA biosynthetic process
TthSNM76_16880	COG0314	molybdopterin synthase activity
TthSNM76_16910	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
TthSNM76_16930	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
TthSNM76_16950	COG0277	FAD linked oxidase domain protein
TthSNM76_17010	COG1126	abc transporter atp-binding protein
TthSNM76_17020	COG2720	vancomycin resistance protein
TthSNM76_17040	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
TthSNM76_17050	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
TthSNM76_17050	COG1372	Participates in initiation and elongation during chromosome replication
TthSNM76_17060	COG0135	phosphoribosylanthranilate isomerase activity
TthSNM76_17090	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
TthSNM76_17120	COG4712	double-strand break repair protein
TthSNM76_17140	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
TthSNM76_17150	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
TthSNM76_17160	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
TthSNM76_17170	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
TthSNM76_17180	COG0649	NAD binding
TthSNM76_17190	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
TthSNM76_17200	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
TthSNM76_17210	COG1034	ATP synthesis coupled electron transport
TthSNM76_17220	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
TthSNM76_17230	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
TthSNM76_17240	COG0839	Belongs to the complex I subunit 6 family
TthSNM76_17250	COG0713	ATP synthesis coupled electron transport
TthSNM76_17260	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
TthSNM76_17270	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
TthSNM76_17280	COG1007	ATP synthesis coupled electron transport
TthSNM76_17290	COG0018	arginyl-trna synthetase
TthSNM76_17300	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
TthSNM76_17310	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
TthSNM76_17340	COG2070	2-Nitropropane dioxygenase
TthSNM76_17370	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
TthSNM76_17400	COG0513	Belongs to the DEAD box helicase family
TthSNM76_17410	COG0303	'Molybdopterin
TthSNM76_17450	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
TthSNM76_17460	COG0442	prolyl-tRNA aminoacylation
TthSNM76_17470	COG3635	2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity
TthSNM76_17490	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
TthSNM76_17510	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
TthSNM76_17520	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
TthSNM76_17520	COG0758	DNA mediated transformation
TthSNM76_17530	COG3546	catalase activity
TthSNM76_17540	COG0583	DNA-binding transcription factor activity
TthSNM76_17580	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
TthSNM76_17590	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
TthSNM76_17600	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
TthSNM76_17610	COG0717	Belongs to the dCTP deaminase family
TthSNM76_17640	COG0300	oxidoreductase activity
TthSNM76_17650	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
TthSNM76_17690	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
TthSNM76_17690	COG0515	serine threonine protein kinase
TthSNM76_17710	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
TthSNM76_17730	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
TthSNM76_17740	COG0704	Plays a role in the regulation of phosphate uptake
TthSNM76_17750	COG4191	Histidine kinase
TthSNM76_17760	COG0745	RESPONSE REGULATOR receiver
TthSNM76_17770	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
TthSNM76_17790	COG1187	pseudouridine synthase activity
TthSNM76_17810	COG1459	type II secretion system
TthSNM76_17880	COG2165	general secretion pathway protein
TthSNM76_17890	COG2165	general secretion pathway protein
TthSNM76_17910	COG2165	general secretion pathway protein
TthSNM76_17930	COG2414	aldehyde ferredoxin oxidoreductase
TthSNM76_17980	COG1902	pentaerythritol trinitrate reductase activity
TthSNM76_18070	COG0315	cyclic pyranopterin monophosphate synthase activity
TthSNM76_18090	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
TthSNM76_18120	COG1694	Mazg nucleotide pyrophosphohydrolase
TthSNM76_18130	COG1803	Methylglyoxal synthase
TthSNM76_18150	COG0301	tRNA thio-modification
TthSNM76_18160	COG0154	amidase activity
TthSNM76_18170	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
TthSNM76_18200	COG2154	pterin-4-alpha-carbinolamine dehydratase
TthSNM76_18210	COG1607	acyl-coa hydrolase
TthSNM76_18230	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
TthSNM76_18240	COG4149	molybdate abc transporter
TthSNM76_18250	COG1840	ABC-type Fe3 transport system, periplasmic component
TthSNM76_18280	COG0235	Class ii aldolase
TthSNM76_18290	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
TthSNM76_18300	COG0085	RNA polymerase activity
TthSNM76_18320	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
TthSNM76_18330	COG1077	Cell shape determining protein MreB Mrl
TthSNM76_18340	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
TthSNM76_18340	COG1418	mRNA catabolic process
TthSNM76_18350	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
TthSNM76_18360	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
TthSNM76_18370	COG1058	Belongs to the CinA family
TthSNM76_18370	COG1546	Belongs to the CinA family
TthSNM76_18380	COG0354	folic acid binding
TthSNM76_18410	COG4948	Mandelate Racemase Muconate Lactonizing
TthSNM76_18440	COG1175	transmembrane transport
TthSNM76_18460	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
TthSNM76_18480	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
TthSNM76_18500	COG0577	efflux transmembrane transporter activity
TthSNM76_18500	COG1136	(ABC) transporter
TthSNM76_18510	COG4181	ATPase activity
TthSNM76_18520	COG0446	pyridine nucleotide-disulphide oxidoreductase
TthSNM76_18550	COG0396	ATPase activity
TthSNM76_18560	COG0719	Fe-S assembly protein
TthSNM76_18570	COG0719	Fe-S assembly protein
TthSNM76_18580	COG2146	nitrite reductase [NAD(P)H] activity
TthSNM76_18600	COG0512	Glutamine amidotransferase of anthranilate synthase
TthSNM76_18610	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
TthSNM76_18630	COG2255	four-way junction helicase activity
TthSNM76_18670	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
TthSNM76_18680	COG2226	methyltransferase
TthSNM76_18690	COG4603	Belongs to the binding-protein-dependent transport system permease family
TthSNM76_18700	COG1079	Belongs to the binding-protein-dependent transport system permease family
TthSNM76_18730	COG1774	PSP1 C-terminal conserved region
TthSNM76_18740	COG0470	DNA polymerase III
TthSNM76_18780	COG0497	DNA recombination
TthSNM76_18840	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
TthSNM76_18870	COG0302	gtp cyclohydrolase
TthSNM76_18920	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
TthSNM76_18940	COG0395	ABC-type sugar transport system, permease component
TthSNM76_18950	COG1804	L-carnitine dehydratase bile acid-inducible protein F
TthSNM76_18960	COG1131	(ABC) transporter
TthSNM76_19000	COG0556	nucleotide-excision repair
TthSNM76_19010	COG0497	DNA recombination
TthSNM76_19020	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
TthSNM76_19030	COG0445	tRNA wobble uridine modification
TthSNM76_19080	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
TthSNM76_19080	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
TthSNM76_19090	COG1543	Belongs to the glycosyl hydrolase 57 family
TthSNM76_19100	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
TthSNM76_19110	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
TthSNM76_19140	COG0189	ligase activity
TthSNM76_19170	COG0066	3-isopropylmalate dehydratase activity
TthSNM76_19180	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
TthSNM76_19210	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
TthSNM76_19220	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
TthSNM76_19230	COG1960	acyl-CoA dehydrogenase activity
TthSNM76_19240	COG0163	prenyltransferase activity
TthSNM76_19290	COG1668	transmembrane transport
TthSNM76_19300	COG4555	ABC transporter
TthSNM76_19320	COG2096	Adenosyltransferase
TthSNM76_19350	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
TthSNM76_19360	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
TthSNM76_19390	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
TthSNM76_19400	COG0723	plastoquinol--plastocyanin reductase activity
TthSNM76_19420	COG2010	Cytochrome c
TthSNM76_19450	COG1653	transport
TthSNM76_19460	COG0820	rRNA (adenine-C2-)-methyltransferase activity
TthSNM76_19470	COG1960	acyl-CoA dehydrogenase activity
TthSNM76_19490	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
TthSNM76_19530	COG0393	Putative heavy-metal-binding
TthSNM76_19550	COG3956	TIGRFAM MazG family protein
TthSNM76_19560	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
TthSNM76_19570	COG0693	protein deglycase activity
TthSNM76_19580	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
TthSNM76_19600	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
TthSNM76_19610	COG1937	Protein conserved in bacteria
TthSNM76_19630	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
TthSNM76_19630	COG0674	pyruvate-flavodoxin oxidoreductase activity
TthSNM76_19640	COG1013	pyruvate-flavodoxin oxidoreductase activity
TthSNM76_19690	COG0205	6-phosphofructokinase activity
TthSNM76_19700	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
TthSNM76_19720	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
TthSNM76_19750	COG2333	competence protein COMEC
TthSNM76_19750	COG0658	competence protein
TthSNM76_19760	COG1475	DNA binding
TthSNM76_19770	COG1192	Involved in chromosome partitioning
TthSNM76_19780	COG0357	Ribosomal RNA small subunit methyltransferase G
TthSNM76_19910	COG0535	radical SAM domain protein
TthSNM76_19950	COG3335	DDE superfamily endonuclease
TthSNM76_20010	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
TthSNM76_20030	COG0395	ABC-type sugar transport system, permease component
TthSNM76_20040	COG1692	metallophosphoesterase
TthSNM76_20080	COG3454	Phosphonate metabolism
TthSNM76_20090	COG4778	phosphonate C-P lyase system protein PhnL
TthSNM76_20100	COG4107	phosphonate C-P lyase system protein PhnK
TthSNM76_20110	COG3627	carbon phosphorus lyase activity
TthSNM76_20150	COG3639	organic phosphonate transmembrane transporter activity
TthSNM76_20170	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
TthSNM76_20250	COG1475	DNA binding
TthSNM76_20260	COG1192	Involved in chromosome partitioning
TthSNM76_20330	COG4213	ABC transporter substrate-binding protein
TthSNM76_20340	COG4214	carbohydrate transport
TthSNM76_20350	COG1129	ABC transporter
TthSNM76_20380	COG1070	Carbohydrate kinase
TthSNM76_20400	COG0673	inositol 2-dehydrogenase activity
TthSNM76_20410	COG0300	oxidoreductase activity
TthSNM76_20430	COG1175	transmembrane transport
TthSNM76_20440	COG3842	ATPase activity
TthSNM76_20450	COG3290	protein histidine kinase activity
TthSNM76_20460	COG4565	transcriptional regulatory protein
TthSNM76_20490	COG3335	DDE superfamily endonuclease
TthSNM76_20530	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
TthSNM76_20570	COG1857	crispr-associated protein
TthSNM76_20810	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
TthSNM76_20820	COG2079	MmgE PrpD family protein
TthSNM76_20840	COG0134	indole-3-glycerol-phosphate synthase activity
TthSNM76_20880	COG4213	ABC transporter substrate-binding protein
TthSNM76_20890	COG4214	carbohydrate transport
TthSNM76_20900	COG1129	ABC transporter
TthSNM76_20930	COG1070	Carbohydrate kinase
TthSNM76_20950	COG0673	inositol 2-dehydrogenase activity
TthSNM76_20960	COG0300	oxidoreductase activity
TthSNM76_21010	COG0395	ABC-type sugar transport system, permease component
TthSNM76_21020	COG1175	transmembrane transport
TthSNM76_21060	COG1692	metallophosphoesterase
TthSNM76_21130	COG1175	transmembrane transport
TthSNM76_21250	COG1942	4-Oxalocrotonate Tautomerase
TthSNM76_21290	COG2084	Dehydrogenase
TthSNM76_21400	COG3335	DDE superfamily endonuclease
TthSNM76_21480	COG2197	response regulator
TthSNM76_21530	COG1131	(ABC) transporter
TthSNM76_21570	COG0210	DNA helicase
TthSNM76_21630	COG1192	Involved in chromosome partitioning
TthSNM76_21640	COG1475	DNA binding
TthSNM76_21680	COG3335	DDE superfamily endonuclease
TthSNM76_21870	COG2002	toxin-antitoxin pair type II binding
TthSNM76_22010	COG1172	Belongs to the binding-protein-dependent transport system permease family
TthSNM76_22020	COG1172	Belongs to the binding-protein-dependent transport system permease family
TthSNM76_22030	COG1129	ABC transporter
TthSNM76_22040	COG1879	ABC-type sugar transport system periplasmic component
TthSNM76_22110	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
TthSNM76_22200	COG1879	ABC-type sugar transport system periplasmic component
TthSNM76_22210	COG1172	Belongs to the binding-protein-dependent transport system permease family
TthSNM76_22220	COG1129	ABC transporter
TthSNM76_22230	COG1869	D-ribose catabolic process
TthSNM76_22240	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
TthSNM76_22250	COG1609	Transcriptional regulator
TthSNM76_22360	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
TthSNM76_22380	COG2986	histidine ammonia-lyase
TthSNM76_22400	COG4565	transcriptional regulatory protein
TthSNM76_22450	COG3335	DDE superfamily endonuclease
TthSNM76_22480	COG1074	ATP-dependent DNA helicase activity
TthSNM76_22510	COG1203	CRISPR-associated helicase, Cas3
TthSNM76_22540	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
TthSNM76_22570	COG2414	aldehyde ferredoxin oxidoreductase
TthSNM76_22590	COG1110	DNA topoisomerase II activity
TthSNM76_22650	COG0514	ATP-dependent DNA helicase (RecQ)
TthSNM76_22660	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
TthSNM76_22680	COG0747	negative chemotaxis
TthSNM76_22690	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
TthSNM76_22710	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
TthSNM76_22720	COG1012	belongs to the aldehyde dehydrogenase family
TthSNM76_22750	COG0395	ABC-type sugar transport system, permease component
TthSNM76_22760	COG1175	transmembrane transport
TthSNM76_22780	COG1609	Transcriptional regulator
TthSNM76_22810	COG0863	Belongs to the N(4) N(6)-methyltransferase family
TthSNM76_22860	COG1857	crispr-associated protein
TthSNM76_22900	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
TthSNM76_22910	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
TthSNM76_22960	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
TthSNM76_22970	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
TthSNM76_23000	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
TthSNM76_23010	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
TthSNM76_23160	COG4974	Belongs to the 'phage' integrase family
TthSNM76_23440	COG2211	Major facilitator Superfamily
TthSNM76_23480	COG2211	Major facilitator Superfamily
TthSNM76_23520	COG1797	cobyrinic acid a,c-diamide synthase activity
TthSNM76_23530	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
TthSNM76_23550	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
TthSNM76_23580	COG0588	phosphoglycerate mutase activity
TthSNM76_23590	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
TthSNM76_23600	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
TthSNM76_23690	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
TthSNM76_23690	COG1648	precorrin-2 dehydrogenase activity
TthSNM76_23700	COG0778	Nitroreductase
TthSNM76_23710	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
TthSNM76_23740	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
TthSNM76_23770	COG1492	cobalamin metabolic process
TthSNM76_23780	COG1785	Belongs to the alkaline phosphatase family
TthSNM76_23830	COG0800	Aldolase
TthSNM76_23840	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
TthSNM76_23880	COG2723	6-phospho-beta-galactosidase activity
TthSNM76_23890	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
TthSNM76_23930	COG1233	COG1233 Phytoene dehydrogenase and related
TthSNM76_23940	COG0702	epimerase
TthSNM76_24000	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
TthSNM76_24020	COG1562	ergosterol biosynthetic process
TthSNM76_24040	COG2124	cytochrome p450
TthSNM76_24090	COG1487	ribonuclease activity
TthSNM76_24110	COG1304	FMN binding
TthSNM76_24150	COG1085	galactose-1-phosphate uridylyltransferase
TthSNM76_24160	COG3345	alpha-galactosidase
TthSNM76_24230	COG4966	pilus assembly protein PilW
TthSNM76_24280	COG1475	DNA binding
TthSNM76_24290	COG1192	Involved in chromosome partitioning
TthSNM76_24360	COG2010	Cytochrome c
TthSNM76_24370	COG0535	radical SAM domain protein
TthSNM76_24380	COG2010	Cytochrome c
TthSNM76_24420	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
TthSNM76_24540	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
TthSNM76_24550	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
TthSNM76_24560	COG1252	NADH dehydrogenase
TthSNM76_24600	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
TthSNM76_24670	COG2151	metal-sulfur cluster biosynthetic enzyme
TthSNM76_24690	COG2814	Major facilitator Superfamily
TthSNM76_24710	COG0584	glycerophosphoryl diester phosphodiesterase
TthSNM76_24740	COG4974	Belongs to the 'phage' integrase family
TthSNM76_24970	COG4876	unkown
TthSNM76_t00230	COG0544	peptidyl-prolyl cis-trans isomerase activity