locus-tag	class	description
TthTMY_00010	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
TthTMY_00030	COG0148	phosphopyruvate hydratase activity
TthTMY_00040	COG0469	pyruvate kinase activity
TthTMY_00070	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
TthTMY_00090	COG1842	Phage shock protein A
TthTMY_00130	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
TthTMY_00140	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
TthTMY_00160	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
TthTMY_00170	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
TthTMY_00180	COG1496	oxidoreductase activity
TthTMY_00190	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
TthTMY_00200	COG1278	Cold shock
TthTMY_00220	COG1653	transport
TthTMY_00250	COG0033	Phosphoglucomutase
TthTMY_00270	COG2814	Major facilitator Superfamily
TthTMY_00310	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
TthTMY_00330	COG0181	hydroxymethylbilane synthase activity
TthTMY_00350	COG0285	dihydrofolate synthase activity
TthTMY_00360	COG0436	Aminotransferase
TthTMY_00370	COG0521	Mo-molybdopterin cofactor biosynthetic process
TthTMY_00420	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
TthTMY_00430	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
TthTMY_00440	COG1993	acr, cog1993
TthTMY_00450	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
TthTMY_00470	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
TthTMY_00490	COG1335	isochorismatase
TthTMY_00500	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
TthTMY_00530	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
TthTMY_00540	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
TthTMY_00580	COG1660	Displays ATPase and GTPase activities
TthTMY_00590	COG0391	Required for morphogenesis under gluconeogenic growth conditions
TthTMY_00690	COG3335	DDE superfamily endonuclease
TthTMY_00810	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
TthTMY_00820	COG2226	methyltransferase
TthTMY_00870	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
TthTMY_00880	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
TthTMY_00890	COG0022	dehydrogenase e1 component
TthTMY_00900	COG1598	PFAM Uncharacterised protein family UPF0150
TthTMY_00930	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
TthTMY_01030	COG3335	DDE superfamily endonuclease
TthTMY_01060	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
TthTMY_01070	COG0321	lipoyl(octanoyl) transferase activity
TthTMY_01080	COG0300	oxidoreductase activity
TthTMY_01110	COG0359	binds to the 23S rRNA
TthTMY_01120	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
TthTMY_01130	COG0629	single-stranded DNA binding
TthTMY_01150	COG0081	regulation of translation
TthTMY_01170	COG0250	Participates in transcription elongation, termination and antitermination
TthTMY_01180	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
TthTMY_01190	COG0267	Belongs to the bacterial ribosomal protein bL33 family
TthTMY_01210	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
TthTMY_01240	COG0735	belongs to the Fur family
TthTMY_01270	COG0482	sulfurtransferase activity
TthTMY_01280	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
TthTMY_01290	COG0573	inorganic phosphate transmembrane transporter activity
TthTMY_01300	COG0581	inorganic phosphate transmembrane transporter activity
TthTMY_01310	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
TthTMY_01330	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
TthTMY_01350	COG0791	NLP P60 protein
TthTMY_01350	COG1388	LysM domain
TthTMY_01390	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
TthTMY_01400	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
TthTMY_01410	COG0459	protein refolding
TthTMY_01420	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
TthTMY_01430	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
TthTMY_01460	COG0166	Belongs to the GPI family
TthTMY_01470	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
TthTMY_01490	COG0505	Belongs to the CarA family
TthTMY_01510	COG0165	Argininosuccinate lyase
TthTMY_01520	COG0137	argininosuccinate synthase activity
TthTMY_01540	COG0508	dehydrogenase complex catalyzes the overall conversion of
TthTMY_01560	COG1024	Enoyl-CoA hydratase
TthTMY_01570	COG0632	four-way junction helicase activity
TthTMY_01580	COG1011	Hydrolase
TthTMY_01600	COG1611	Belongs to the LOG family
TthTMY_01610	COG0589	response to stress
TthTMY_01620	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
TthTMY_01630	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
TthTMY_01710	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
TthTMY_01720	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
TthTMY_01730	COG0343	queuine tRNA-ribosyltransferase activity
TthTMY_01760	COG0109	protoheme IX farnesyltransferase activity
TthTMY_01760	COG1612	heme a metabolic process
TthTMY_01770	COG2010	Cytochrome c
TthTMY_01770	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
TthTMY_01780	COG1845	cytochrome c oxidase, subunit III
TthTMY_01780	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
TthTMY_01800	COG0582	viral genome integration into host DNA
TthTMY_01810	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
TthTMY_01850	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
TthTMY_01860	COG1187	pseudouridine synthase activity
TthTMY_01870	COG1024	Enoyl-CoA hydratase
TthTMY_01880	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
TthTMY_01890	COG0686	Belongs to the AlaDH PNT family
TthTMY_01910	COG1461	Dihydroxyacetone kinase
TthTMY_01940	COG4591	ABC-type transport system involved in lipoprotein release permease component
TthTMY_01950	COG0222	ribosome binding
TthTMY_01960	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
TthTMY_01980	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
TthTMY_02040	COG0243	molybdopterin cofactor binding
TthTMY_02050	COG2272	Belongs to the type-B carboxylesterase lipase family
TthTMY_02060	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
TthTMY_02080	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
TthTMY_02110	COG0477	Major facilitator Superfamily
TthTMY_02140	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
TthTMY_02160	COG0105	UTP biosynthetic process
TthTMY_02170	COG0631	protein serine/threonine phosphatase activity
TthTMY_02180	COG0583	DNA-binding transcription factor activity
TthTMY_02200	COG0508	dehydrogenase complex catalyzes the overall conversion of
TthTMY_02260	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
TthTMY_02280	COG1278	Cold shock
TthTMY_02290	COG0484	heat shock protein binding
TthTMY_02300	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
TthTMY_02310	COG1968	undecaprenyl-diphosphatase activity
TthTMY_02320	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
TthTMY_02330	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
TthTMY_02360	COG1309	transcriptional regulator
TthTMY_02370	COG4242	Belongs to the peptidase S51 family
TthTMY_02400	COG0802	atpase or kinase
TthTMY_02420	COG0049	tRNA binding
TthTMY_02450	COG0051	transcription antitermination factor activity, RNA binding
TthTMY_02470	COG0088	Forms part of the polypeptide exit tunnel
TthTMY_02480	COG0089	rRNA binding
TthTMY_02490	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
TthTMY_02500	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
TthTMY_02520	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
TthTMY_02530	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
TthTMY_02540	COG0255	Belongs to the universal ribosomal protein uL29 family
TthTMY_02560	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
TthTMY_02590	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
TthTMY_02600	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
TthTMY_02610	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
TthTMY_02660	COG0201	protein transport
TthTMY_02670	COG0563	adenylate kinase activity
TthTMY_02690	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
TthTMY_02700	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
TthTMY_02710	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
TthTMY_02720	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
TthTMY_02730	COG0202	RNA polymerase activity
TthTMY_02740	COG0203	ribosomal protein L17
TthTMY_02800	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
TthTMY_02860	COG0142	geranyltranstransferase activity
TthTMY_02870	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
TthTMY_02940	COG0366	Alpha amylase catalytic
TthTMY_02960	COG1193	negative regulation of DNA recombination
TthTMY_02970	COG1611	Belongs to the LOG family
TthTMY_02980	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
TthTMY_02990	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
TthTMY_03010	COG1166	arginine decarboxylase activity
TthTMY_03040	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
TthTMY_03050	COG0006	proline dipeptidase activity
TthTMY_03060	COG0316	Belongs to the HesB IscA family
TthTMY_03080	COG0601	transmembrane transport
TthTMY_03090	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
TthTMY_03100	COG0101	tRNA pseudouridine synthase activity
TthTMY_03110	COG3842	ATPase activity
TthTMY_03130	COG1840	ABC-type Fe3 transport system, periplasmic component
TthTMY_03170	COG1764	response to oxidative stress
TthTMY_03190	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
TthTMY_03200	COG2897	thiosulfate sulfurtransferase activity
TthTMY_03220	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
TthTMY_03230	COG0220	tRNA (guanine-N7-)-methyltransferase activity
TthTMY_03240	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
TthTMY_03250	COG0537	adenosine 5'-monophosphoramidase activity
TthTMY_03300	COG1011	Hydrolase
TthTMY_03310	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
TthTMY_03350	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
TthTMY_03360	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
TthTMY_03370	COG1506	peptidase
TthTMY_03370	COG4946	Tricorn protease homolog
TthTMY_03370	COG0823	Involved in the tonB-independent uptake of proteins
TthTMY_03410	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
TthTMY_03420	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
TthTMY_03430	COG0113	porphobilinogen synthase activity
TthTMY_03460	COG0631	protein serine/threonine phosphatase activity
TthTMY_03470	COG2815	serine threonine protein kinase
TthTMY_03470	COG0515	serine threonine protein kinase
TthTMY_03520	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
TthTMY_03530	COG0193	aminoacyl-tRNA hydrolase activity
TthTMY_03540	COG1181	Belongs to the D-alanine--D-alanine ligase family
TthTMY_03550	COG0187	DNA topoisomerase II activity
TthTMY_03580	COG0827	DNA restriction-modification system
TthTMY_03580	COG0732	type I restriction modification DNA specificity domain
TthTMY_03590	COG0156	8-amino-7-oxononanoate synthase activity
TthTMY_03630	COG0506	proline dehydrogenase activity
TthTMY_03640	COG1012	belongs to the aldehyde dehydrogenase family
TthTMY_03650	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
TthTMY_03660	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
TthTMY_03740	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
TthTMY_03760	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
TthTMY_03770	COG2385	sporulation resulting in formation of a cellular spore
TthTMY_03780	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
TthTMY_03800	COG0194	GDP metabolic process
TthTMY_03810	COG1758	RNA polymerase activity
TthTMY_03820	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
TthTMY_03830	COG1438	arginine binding
TthTMY_03840	COG2095	MarC family integral membrane protein
TthTMY_03850	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
TthTMY_03860	COG0328	RNA-DNA hybrid ribonuclease activity
TthTMY_03900	COG4274	PFAM GYD family protein
TthTMY_03910	COG4636	protein conserved in cyanobacteria
TthTMY_03920	COG0519	Catalyzes the synthesis of GMP from XMP
TthTMY_03920	COG0518	GMP synthase (glutamine-hydrolyzing) activity
TthTMY_03930	COG1854	S-ribosylhomocysteine lyase activity
TthTMY_03940	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
TthTMY_03950	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
TthTMY_03960	COG0322	excinuclease ABC activity
TthTMY_03980	COG2050	protein possibly involved in aromatic compounds catabolism
TthTMY_04020	COG0037	tRNA processing
TthTMY_04020	COG0590	tRNA wobble adenosine to inosine editing
TthTMY_04030	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
TthTMY_04040	COG0538	isocitrate dehydrogenase activity
TthTMY_04050	COG0557	exoribonuclease II activity
TthTMY_04080	COG0585	pseudouridine synthase activity
TthTMY_04120	COG0604	alcohol dehydrogenase
TthTMY_04140	COG0497	DNA recombination
TthTMY_04150	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
TthTMY_04180	COG0116	Belongs to the methyltransferase superfamily
TthTMY_04190	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
TthTMY_04200	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
TthTMY_04220	COG0047	phosphoribosylformylglycinamidine synthase activity
TthTMY_04240	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
TthTMY_04270	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
TthTMY_04340	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
TthTMY_04370	COG5002	protein histidine kinase activity
TthTMY_04370	COG3850	Histidine kinase
TthTMY_04390	COG1272	protein, Hemolysin III
TthTMY_04400	COG0574	Belongs to the PEP-utilizing enzyme family
TthTMY_04400	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
TthTMY_04410	COG0714	Associated with various cellular activities
TthTMY_04420	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
TthTMY_04430	COG1310	metal-dependent protease of the Pad1 Jab1 superfamily
TthTMY_04460	COG0616	signal peptide processing
TthTMY_04470	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
TthTMY_04480	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
TthTMY_04490	COG0443	Heat shock 70 kDa protein
TthTMY_04500	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
TthTMY_04510	COG0484	heat shock protein binding
TthTMY_04520	COG0789	Transcriptional regulator
TthTMY_04530	COG0542	response to heat
TthTMY_04580	COG3118	belongs to the thioredoxin family
TthTMY_04620	COG0490	domain, Protein
TthTMY_04630	COG0475	glutathione-regulated potassium exporter activity
TthTMY_04660	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
TthTMY_04660	COG0617	tRNA 3'-terminal CCA addition
TthTMY_04660	COG0517	IMP dehydrogenase activity
TthTMY_04670	COG0475	glutathione-regulated potassium exporter activity
TthTMY_04690	COG0305	Participates in initiation and elongation during chromosome replication
TthTMY_04700	COG0840	transmembrane signaling receptor activity
TthTMY_04770	COG0067	glutamate synthase
TthTMY_04770	COG0070	glutamate synthase
TthTMY_04770	COG0069	glutamate synthase activity
TthTMY_04780	COG0070	glutamate synthase
TthTMY_04780	COG0069	glutamate synthase activity
TthTMY_04780	COG0067	glutamate synthase
TthTMY_04810	COG0504	CTP synthase activity
TthTMY_04820	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
TthTMY_04830	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
TthTMY_04840	COG0318	PFAM AMP-dependent synthetase and ligase
TthTMY_04900	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
TthTMY_04910	COG2009	succinate dehydrogenase
TthTMY_04940	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
TthTMY_04950	COG0017	Asparaginyl-tRNA synthetase
TthTMY_04980	COG0084	hydrolase, TatD family'
TthTMY_04990	COG0427	acetyl-CoA hydrolase
TthTMY_05000	COG0686	Belongs to the AlaDH PNT family
TthTMY_05010	COG1494	fructose-1,6-bisphosphatase
TthTMY_05020	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
TthTMY_05020	COG0140	phosphoribosyl-ATP diphosphatase activity
TthTMY_05030	COG0107	imidazoleglycerol-phosphate synthase activity
TthTMY_05050	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
TthTMY_05070	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
TthTMY_05080	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
TthTMY_05090	COG2045	Belongs to the ComB family
TthTMY_05100	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
TthTMY_05110	COG1136	(ABC) transporter
TthTMY_05130	COG1024	Enoyl-CoA hydratase
TthTMY_05160	COG3360	Dodecin
TthTMY_05170	COG0318	PFAM AMP-dependent synthetase and ligase
TthTMY_05230	COG3842	ATPase activity
TthTMY_05240	COG2010	Cytochrome c
TthTMY_05280	COG3258	Cytochrome c
TthTMY_05290	COG2010	Cytochrome c
TthTMY_05310	COG2010	Cytochrome c
TthTMY_05320	COG3258	Cytochrome c
TthTMY_05380	COG3258	Cytochrome c
TthTMY_05390	COG0785	Cytochrome C biogenesis protein
TthTMY_05400	COG4133	protoheme IX ABC transporter activity
TthTMY_05410	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
TthTMY_05420	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
TthTMY_05430	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
TthTMY_05440	COG1138	Cytochrome C-type biogenesis protein
TthTMY_05450	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
TthTMY_05460	COG3088	subunit of a heme lyase
TthTMY_05460	COG4235	cytochrome complex assembly
TthTMY_05510	COG5343	regulation of RNA biosynthetic process
TthTMY_05580	COG3706	GGDEF domain
TthTMY_05590	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
TthTMY_05610	COG0268	Binds directly to 16S ribosomal RNA
TthTMY_05630	COG0083	homoserine kinase activity
TthTMY_05650	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
TthTMY_05650	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
TthTMY_05660	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
TthTMY_05670	COG1160	GTP binding
TthTMY_05690	COG0736	holo-[acyl-carrier-protein] synthase activity
TthTMY_05700	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
TthTMY_05700	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
TthTMY_05710	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
TthTMY_05720	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
TthTMY_05730	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
TthTMY_05740	COG1450	Type ii and iii secretion system protein
TthTMY_05790	COG0473	3-isopropylmalate dehydrogenase activity
TthTMY_05850	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
TthTMY_05870	COG0860	N-Acetylmuramoyl-L-alanine amidase
TthTMY_05890	COG0515	serine threonine protein kinase
TthTMY_05890	COG2815	serine threonine protein kinase
TthTMY_05900	COG1752	Esterase of the alpha-beta hydrolase superfamily
TthTMY_05920	COG1556	Lactate utilization protein
TthTMY_05930	COG1139	Iron-sulfur cluster binding protein
TthTMY_05940	COG0247	lactate metabolic process
TthTMY_05960	COG2205	protein histidine kinase activity
TthTMY_06000	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
TthTMY_06030	COG1324	tolerance protein
TthTMY_06040	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
TthTMY_06050	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
TthTMY_06070	COG0739	heme binding
TthTMY_06080	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
TthTMY_06090	COG2197	response regulator
TthTMY_06120	COG0776	regulation of translation
TthTMY_06140	COG1515	deoxyribonuclease V activity
TthTMY_06160	COG1482	cell wall glycoprotein biosynthetic process
TthTMY_06170	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
TthTMY_06180	COG0372	Belongs to the citrate synthase family
TthTMY_06190	COG1132	(ABC) transporter
TthTMY_06200	COG1132	(ABC) transporter
TthTMY_06210	COG0285	dihydrofolate synthase activity
TthTMY_06230	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
TthTMY_06270	COG0559	Belongs to the binding-protein-dependent transport system permease family
TthTMY_06290	COG0174	glutamine synthetase
TthTMY_06300	COG0737	Belongs to the 5'-nucleotidase family
TthTMY_06320	COG2010	Cytochrome c
TthTMY_06350	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
TthTMY_06360	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
TthTMY_06370	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
TthTMY_06380	COG0788	formyltetrahydrofolate deformylase activity
TthTMY_06390	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
TthTMY_06420	COG2358	TRAP transporter, solute receptor (TAXI family
TthTMY_06450	COG1994	Peptidase M50
TthTMY_06450	COG0517	IMP dehydrogenase activity
TthTMY_06470	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
TthTMY_06480	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
TthTMY_06490	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
TthTMY_06530	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
TthTMY_06550	COG0746	molybdenum cofactor guanylyltransferase activity
TthTMY_06560	COG1129	ABC transporter
TthTMY_06570	COG4603	Belongs to the binding-protein-dependent transport system permease family
TthTMY_06580	COG1079	Belongs to the binding-protein-dependent transport system permease family
TthTMY_06600	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
TthTMY_06610	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
TthTMY_06620	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
TthTMY_06620	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
TthTMY_06640	COG0793	Belongs to the peptidase S41A family
TthTMY_06650	COG2884	Cell division ATP-binding protein ftsE
TthTMY_06660	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
TthTMY_06700	COG0420	3'-5' exonuclease activity
TthTMY_06710	COG0419	ATPase involved in DNA repair
TthTMY_06750	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
TthTMY_06770	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
TthTMY_06820	COG1269	ATP hydrolysis coupled proton transport
TthTMY_06840	COG1390	Produces ATP from ADP in the presence of a proton gradient across the membrane
TthTMY_06850	COG1527	subunit (C
TthTMY_06860	COG1436	Produces ATP from ADP in the presence of a proton gradient across the membrane
TthTMY_06870	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
TthTMY_06880	COG1156	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit
TthTMY_06890	COG1394	ATPase activity, coupled to movement of substances
TthTMY_06920	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
TthTMY_06930	COG0612	Peptidase, M16
TthTMY_06940	COG0612	Peptidase, M16
TthTMY_06950	COG0697	spore germination
TthTMY_06960	COG1250	3-hydroxyacyl-CoA dehydrogenase
TthTMY_06980	COG0358	DNA primase activity
TthTMY_07010	COG1111	helicase
TthTMY_07010	COG1205	dead DEAH box helicase
TthTMY_07020	COG0393	Putative heavy-metal-binding
TthTMY_07060	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
TthTMY_07070	COG0653	protein targeting
TthTMY_07080	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
TthTMY_07090	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
TthTMY_07100	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
TthTMY_07120	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
TthTMY_07120	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
TthTMY_07140	COG1733	regulation of RNA biosynthetic process
TthTMY_07150	COG2894	cell division
TthTMY_07160	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
TthTMY_07170	COG0772	Belongs to the SEDS family
TthTMY_07180	COG3842	ATPase activity
TthTMY_07190	COG1176	ABC-type spermidine putrescine transport system, permease component I
TthTMY_07200	COG1177	transmembrane transport
TthTMY_07210	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
TthTMY_07230	COG0129	dihydroxy-acid dehydratase activity
TthTMY_07270	COG0473	3-isopropylmalate dehydrogenase activity
TthTMY_07280	COG0066	3-isopropylmalate dehydratase activity
TthTMY_07290	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
TthTMY_07300	COG0180	Tryptophanyl-tRNA synthetase
TthTMY_07330	COG4636	protein conserved in cyanobacteria
TthTMY_07360	COG2165	general secretion pathway protein
TthTMY_07420	COG4970	Tfp pilus assembly protein FimT
TthTMY_07430	COG0492	ferredoxin-NADP+ reductase activity
TthTMY_07440	COG0028	Belongs to the TPP enzyme family
TthTMY_07450	COG0440	acetolactate synthase activity
TthTMY_07460	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
TthTMY_07480	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
TthTMY_07510	COG1131	(ABC) transporter
TthTMY_07550	COG2165	general secretion pathway protein
TthTMY_07570	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
TthTMY_07600	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
TthTMY_07620	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
TthTMY_07630	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
TthTMY_07690	COG2322	membrane
TthTMY_07710	COG0768	penicillin binding
TthTMY_07750	COG0424	maF-like protein
TthTMY_07770	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
TthTMY_07780	COG0012	GTP binding
TthTMY_07800	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
TthTMY_07810	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
TthTMY_07830	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
TthTMY_07840	COG3001	Fructosamine kinase
TthTMY_07860	COG2313	pseudouridylate synthase activity
TthTMY_07870	COG1426	Protein conserved in bacteria
TthTMY_07880	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
TthTMY_07890	COG0569	domain protein
TthTMY_07900	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
TthTMY_07920	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
TthTMY_07930	COG0765	amino acid transport
TthTMY_07990	COG4607	ABC-type enterochelin transport system periplasmic component
TthTMY_08010	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
TthTMY_08020	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
TthTMY_08030	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
TthTMY_08050	COG2329	Antibiotic biosynthesis monooxygenase
TthTMY_08060	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
TthTMY_08080	COG1607	acyl-coa hydrolase
TthTMY_08170	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
TthTMY_08190	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
TthTMY_08190	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
TthTMY_08230	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
TthTMY_08240	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
TthTMY_08270	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
TthTMY_08280	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
TthTMY_08330	COG2814	Major facilitator Superfamily
TthTMY_08350	COG0584	glycerophosphoryl diester phosphodiesterase
TthTMY_08390	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
TthTMY_08570	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
TthTMY_08600	COG1337	RAMP superfamily
TthTMY_08640	COG2391	methyltransferase activity
TthTMY_08660	COG2226	methyltransferase
TthTMY_08680	COG1233	COG1233 Phytoene dehydrogenase and related
TthTMY_08690	COG0702	epimerase
TthTMY_08740	COG2414	aldehyde ferredoxin oxidoreductase
TthTMY_08880	COG0723	plastoquinol--plastocyanin reductase activity
TthTMY_08890	COG0243	molybdopterin cofactor binding
TthTMY_08910	COG3335	DDE superfamily endonuclease
TthTMY_08940	COG3345	alpha-galactosidase
TthTMY_08950	COG1085	galactose-1-phosphate uridylyltransferase
TthTMY_09000	COG1304	FMN binding
TthTMY_09090	COG1562	ergosterol biosynthetic process
TthTMY_09110	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
TthTMY_09150	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
TthTMY_09170	COG1028	Short-chain dehydrogenase reductase Sdr
TthTMY_09200	COG1028	Short-chain dehydrogenase reductase Sdr
TthTMY_09210	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
TthTMY_09230	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
TthTMY_09240	COG1414	Transcriptional regulator
TthTMY_09270	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
TthTMY_09300	COG0803	Belongs to the bacterial solute-binding protein 9 family
TthTMY_09350	COG1785	Belongs to the alkaline phosphatase family
TthTMY_09360	COG1492	cobalamin metabolic process
TthTMY_09390	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
TthTMY_09410	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
TthTMY_09420	COG0778	Nitroreductase
TthTMY_09520	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
TthTMY_09530	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
TthTMY_09540	COG0588	phosphoglycerate mutase activity
TthTMY_09580	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
TthTMY_09610	COG1797	cobyrinic acid a,c-diamide synthase activity
TthTMY_09700	COG2211	Major facilitator Superfamily
TthTMY_09740	COG2211	Major facilitator Superfamily
TthTMY_09820	COG1337	RAMP superfamily
TthTMY_09890	COG1518	maintenance of DNA repeat elements
TthTMY_09960	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
TthTMY_10030	COG1802	Transcriptional regulator
TthTMY_10050	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
TthTMY_10160	COG2084	Dehydrogenase
TthTMY_10200	COG1942	4-Oxalocrotonate Tautomerase
TthTMY_10340	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
TthTMY_10360	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
TthTMY_10370	COG0134	indole-3-glycerol-phosphate synthase activity
TthTMY_10390	COG3311	Transcriptional regulator
TthTMY_10400	COG1752	Esterase of the alpha-beta hydrolase superfamily
TthTMY_10420	COG1126	abc transporter atp-binding protein
TthTMY_10440	COG2358	TRAP transporter, solute receptor (TAXI family
TthTMY_10450	COG2873	o-acetylhomoserine
TthTMY_10460	COG2309	aminopeptidase activity
TthTMY_10500	COG1796	DNA polymerase
TthTMY_10500	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
TthTMY_10510	COG1573	uracil-dna glycosylase
TthTMY_10520	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
TthTMY_10540	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
TthTMY_10550	COG2086	electron transfer activity
TthTMY_10560	COG1960	acyl-CoA dehydrogenase activity
TthTMY_10570	COG5002	protein histidine kinase activity
TthTMY_10580	COG0745	RESPONSE REGULATOR receiver
TthTMY_10590	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
TthTMY_10600	COG2239	Acts as a magnesium transporter
TthTMY_10610	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
TthTMY_10620	COG1185	polyribonucleotide nucleotidyltransferase activity
TthTMY_10630	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
TthTMY_10650	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
TthTMY_10660	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
TthTMY_10680	COG1100	Small GTP-binding protein
TthTMY_10710	COG0010	Belongs to the arginase family
TthTMY_10750	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
TthTMY_10760	COG0511	ligase activity, forming carbon-carbon bonds
TthTMY_10770	COG0439	Biotin carboxylase
TthTMY_10790	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
TthTMY_10800	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
TthTMY_10810	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
TthTMY_10830	COG2181	nitrate reductase activity
TthTMY_10830	COG0247	lactate metabolic process
TthTMY_10850	COG0861	Integral membrane protein TerC family
TthTMY_10870	COG0039	L-malate dehydrogenase activity
TthTMY_10890	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
TthTMY_10900	COG0438	transferase activity, transferring glycosyl groups
TthTMY_10960	COG0745	RESPONSE REGULATOR receiver
TthTMY_11020	COG3845	ABC transporter
TthTMY_11030	COG1744	ABC transporter substrate-binding protein PnrA-like
TthTMY_11040	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
TthTMY_11050	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
TthTMY_11060	COG0133	tryptophan synthase activity
TthTMY_11070	COG0159	tryptophan synthase activity
TthTMY_11080	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
TthTMY_11100	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
TthTMY_11140	COG0812	UDP-N-acetylmuramate dehydrogenase activity
TthTMY_11150	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
TthTMY_11160	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
TthTMY_11170	COG0772	Belongs to the SEDS family
TthTMY_11180	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
TthTMY_11190	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
TthTMY_11210	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
TthTMY_11220	COG0768	penicillin binding
TthTMY_11240	COG0275	rRNA processing
TthTMY_11250	COG2001	Belongs to the MraZ family
TthTMY_11270	COG0254	rRNA binding
TthTMY_11280	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
TthTMY_11320	COG0006	proline dipeptidase activity
TthTMY_11330	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
TthTMY_11340	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
TthTMY_11350	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
TthTMY_11360	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
TthTMY_11360	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
TthTMY_11380	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
TthTMY_11380	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
TthTMY_11390	COG2304	oxidoreductase activity
TthTMY_11400	COG2239	Acts as a magnesium transporter
TthTMY_11410	COG1397	ADP-ribosylglycohydrolase
TthTMY_11420	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
TthTMY_11440	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
TthTMY_11450	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
TthTMY_11450	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
TthTMY_11490	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
TthTMY_11510	COG4864	UPF0365 protein
TthTMY_11530	COG1702	phosphate starvation-inducible protein PhoH
TthTMY_11540	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
TthTMY_11550	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
TthTMY_11580	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
TthTMY_11600	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
TthTMY_11610	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
TthTMY_11610	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
TthTMY_11630	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
TthTMY_11660	COG0228	four-way junction DNA binding
TthTMY_11670	COG1837	Belongs to the UPF0109 family
TthTMY_11680	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
TthTMY_11690	COG0336	Belongs to the RNA methyltransferase TrmD family
TthTMY_11700	COG0335	large ribosomal subunit rRNA binding
TthTMY_11710	COG2197	response regulator
TthTMY_11720	COG1760	l-serine dehydratase
TthTMY_11730	COG2897	thiosulfate sulfurtransferase activity
TthTMY_11740	COG0582	viral genome integration into host DNA
TthTMY_11800	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
TthTMY_11880	COG1136	(ABC) transporter
TthTMY_11880	COG0577	efflux transmembrane transporter activity
TthTMY_11890	COG1136	(ABC) transporter
TthTMY_11900	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
TthTMY_11930	COG2205	protein histidine kinase activity
TthTMY_11940	COG0745	RESPONSE REGULATOR receiver
TthTMY_12020	COG1012	belongs to the aldehyde dehydrogenase family
TthTMY_12070	COG3335	DDE superfamily endonuclease
TthTMY_12140	COG0477	Major facilitator Superfamily
TthTMY_12150	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
TthTMY_12160	COG0183	Belongs to the thiolase family
TthTMY_12170	COG1331	Highly conserved protein containing a thioredoxin domain
TthTMY_12210	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
TthTMY_12220	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
TthTMY_12230	COG2193	ferroxidase activity
TthTMY_12240	COG1733	regulation of RNA biosynthetic process
TthTMY_12250	COG1980	fructose-bisphosphate aldolase activity
TthTMY_12280	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
TthTMY_12300	COG3396	Phenylacetate-CoA oxygenase
TthTMY_12340	COG1012	belongs to the aldehyde dehydrogenase family
TthTMY_12340	COG2030	dehydratase
TthTMY_12360	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
TthTMY_12370	COG2050	protein possibly involved in aromatic compounds catabolism
TthTMY_12430	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
TthTMY_12440	COG2368	4-hydroxyphenylacetate
TthTMY_12450	COG1012	belongs to the aldehyde dehydrogenase family
TthTMY_12470	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
TthTMY_12490	COG3769	mannosylglycerate metabolic process
TthTMY_12510	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
TthTMY_12520	COG1307	EDD domain protein, DegV family
TthTMY_12530	COG1307	EDD domain protein, DegV family
TthTMY_12540	COG1490	D-aminoacyl-tRNA deacylase activity
TthTMY_12550	COG3239	Fatty acid desaturase
TthTMY_12560	COG0149	triose-phosphate isomerase activity
TthTMY_12640	COG0436	Aminotransferase
TthTMY_12690	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
TthTMY_12720	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
TthTMY_12730	COG0138	bifunctional purine biosynthesis protein purh
TthTMY_12740	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
TthTMY_12750	COG0742	ribosomal rna small subunit methyltransferase
TthTMY_12770	COG0237	dephospho-CoA kinase activity
TthTMY_12780	COG1353	crispr-associated protein
TthTMY_12780	COG0617	tRNA 3'-terminal CCA addition
TthTMY_12790	COG1355	regulation of microtubule-based process
TthTMY_12810	COG0557	exoribonuclease II activity
TthTMY_12830	COG0824	Thioesterase
TthTMY_12840	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
TthTMY_12850	COG0126	phosphoglycerate kinase activity
TthTMY_12870	COG1268	BioY protein
TthTMY_12890	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
TthTMY_12920	COG1196	nuclear chromosome segregation
TthTMY_12960	COG2738	Putative neutral zinc metallopeptidase
TthTMY_12980	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
TthTMY_12990	COG0215	cysteine-tRNA ligase activity
TthTMY_13000	COG1960	acyl-CoA dehydrogenase activity
TthTMY_13010	COG0183	Belongs to the thiolase family
TthTMY_13020	COG1024	Enoyl-CoA hydratase
TthTMY_13020	COG1250	3-hydroxyacyl-CoA dehydrogenase
TthTMY_13070	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
TthTMY_13080	COG0438	transferase activity, transferring glycosyl groups
TthTMY_13100	COG1215	transferase activity, transferring glycosyl groups
TthTMY_13120	COG1215	transferase activity, transferring glycosyl groups
TthTMY_13150	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
TthTMY_13150	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
TthTMY_13160	COG1811	Na channel or pump
TthTMY_13170	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
TthTMY_13180	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
TthTMY_13190	COG4948	Mandelate Racemase Muconate Lactonizing
TthTMY_13210	COG0402	S-adenosylhomocysteine deaminase activity
TthTMY_13270	COG0494	nUDIX hydrolase
TthTMY_13280	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
TthTMY_13290	COG0052	Belongs to the universal ribosomal protein uS2 family
TthTMY_13300	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
TthTMY_13310	COG0528	UMP kinase activity
TthTMY_13320	COG0233	cytoplasmic translational termination
TthTMY_13330	COG0575	Belongs to the CDS family
TthTMY_13340	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
TthTMY_13350	COG0750	zinc metalloprotease
TthTMY_13360	COG0463	Glycosyl transferase, family 2
TthTMY_13380	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
TthTMY_13390	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
TthTMY_13400	COG2359	stage V sporulation protein S
TthTMY_13420	COG2137	regulation of response to DNA damage stimulus
TthTMY_13480	COG2766	serine protein kinase
TthTMY_13490	COG2718	Belongs to the UPF0229 family
TthTMY_13500	COG2719	SpoVR family
TthTMY_13510	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
TthTMY_13520	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
TthTMY_13550	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
TthTMY_13570	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
TthTMY_13580	COG1994	Peptidase M50
TthTMY_13600	COG0617	tRNA 3'-terminal CCA addition
TthTMY_13600	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
TthTMY_13600	COG0517	IMP dehydrogenase activity
TthTMY_13620	COG0517	IMP dehydrogenase activity
TthTMY_13650	COG1674	ftsk spoiiie
TthTMY_13670	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
TthTMY_13680	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
TthTMY_13690	COG4651	solute:proton antiporter activity
TthTMY_13690	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
TthTMY_13700	COG0217	transcriptional regulatory protein
TthTMY_13720	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
TthTMY_13780	COG2176	DNA-directed DNA polymerase activity
TthTMY_13780	COG5002	protein histidine kinase activity
TthTMY_13790	COG0151	Belongs to the GarS family
TthTMY_13800	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
TthTMY_13820	COG0179	Fumarylacetoacetate (FAA) hydrolase
TthTMY_13830	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
TthTMY_13870	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
TthTMY_13880	COG1427	Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
TthTMY_13890	COG2353	YceI-like domain
TthTMY_13910	COG2514	catechol 2,3-dioxygenase activity
TthTMY_13920	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
TthTMY_13930	COG0287	Prephenate dehydrogenase
TthTMY_13950	COG0277	FAD linked oxidase domain protein
TthTMY_13980	COG1459	type II secretion system
TthTMY_14000	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
TthTMY_14020	COG0456	acetyltransferase
TthTMY_14030	COG1960	acyl-CoA dehydrogenase activity
TthTMY_14060	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
TthTMY_14070	COG0730	response to heat
TthTMY_14120	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
TthTMY_14140	COG0167	dihydroorotate dehydrogenase activity
TthTMY_14160	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
TthTMY_14170	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
TthTMY_14270	COG1063	alcohol dehydrogenase
TthTMY_14300	COG3335	DDE superfamily endonuclease
TthTMY_14320	COG2873	o-acetylhomoserine
TthTMY_14330	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
TthTMY_14360	COG1073	alpha beta
TthTMY_14370	COG0405	Gamma-glutamyltransferase
TthTMY_14420	COG1028	Short-chain dehydrogenase reductase Sdr
TthTMY_14450	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
TthTMY_14510	COG0481	GTPase activity
TthTMY_14530	COG1760	l-serine dehydratase
TthTMY_14550	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
TthTMY_14650	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
TthTMY_14660	COG1316	TRANSCRIPTIONal
TthTMY_14690	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
TthTMY_14730	COG1573	uracil-dna glycosylase
TthTMY_14760	COG3842	ATPase activity
TthTMY_14780	COG0124	histidyl-tRNA synthetase
TthTMY_14800	COG0384	phenazine biosynthesis protein PhzF
TthTMY_14810	COG0561	phosphatase activity
TthTMY_14820	COG0017	Asparaginyl-tRNA synthetase
TthTMY_14830	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
TthTMY_14840	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
TthTMY_14850	COG2217	Heavy metal translocating P-type atpase
TthTMY_14860	COG0640	Transcriptional regulator
TthTMY_14870	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
TthTMY_14890	COG0779	Required for maturation of 30S ribosomal subunits
TthTMY_14900	COG0195	Participates in both transcription termination and antitermination
TthTMY_14920	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
TthTMY_14940	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
TthTMY_14940	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
TthTMY_14950	COG1028	Short-chain dehydrogenase reductase Sdr
TthTMY_14980	COG0183	Belongs to the thiolase family
TthTMY_14990	COG0183	Belongs to the thiolase family
TthTMY_15000	COG1940	carbohydrate kinase activity
TthTMY_15020	COG1175	transmembrane transport
TthTMY_15060	COG0477	Major facilitator Superfamily
TthTMY_15070	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
TthTMY_15080	COG2022	thiamine diphosphate biosynthetic process
TthTMY_15080	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
TthTMY_15090	COG2022	thiamine diphosphate biosynthetic process
TthTMY_15100	COG2104	thiamine diphosphate biosynthetic process
TthTMY_15110	COG0352	thiamine-phosphate diphosphorylase activity
TthTMY_15130	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
TthTMY_15140	COG1587	Uroporphyrinogen-III synthase
TthTMY_15150	COG1648	precorrin-2 dehydrogenase activity
TthTMY_15150	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
TthTMY_15160	COG0175	sulfate reduction
TthTMY_15190	COG1648	precorrin-2 dehydrogenase activity
TthTMY_15190	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
TthTMY_15200	COG2046	Belongs to the sulfate adenylyltransferase family
TthTMY_15210	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
TthTMY_15230	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
TthTMY_15230	COG0574	Belongs to the PEP-utilizing enzyme family
TthTMY_15290	COG1385	rRNA (uridine-N3-)-methyltransferase activity
TthTMY_15300	COG2264	protein methyltransferase activity
TthTMY_15320	COG0489	protein tyrosine kinase activity
TthTMY_15370	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
TthTMY_15400	COG1215	transferase activity, transferring glycosyl groups
TthTMY_15410	COG0297	glycogen (starch) synthase activity
TthTMY_15410	COG0438	transferase activity, transferring glycosyl groups
TthTMY_15420	COG0438	transferase activity, transferring glycosyl groups
TthTMY_15440	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
TthTMY_15460	COG1011	Hydrolase
TthTMY_15470	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
TthTMY_15610	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
TthTMY_15620	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
TthTMY_15640	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
TthTMY_15650	COG0582	viral genome integration into host DNA
TthTMY_15680	COG2189	Belongs to the N(4) N(6)-methyltransferase family
TthTMY_15820	COG0745	RESPONSE REGULATOR receiver
TthTMY_15830	COG2205	protein histidine kinase activity
TthTMY_15840	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
TthTMY_15850	COG1692	metallophosphoesterase
TthTMY_15900	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
TthTMY_15920	COG0646	methionine synthase
TthTMY_15920	COG1410	methionine synthase
TthTMY_15930	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
TthTMY_15940	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
TthTMY_15950	COG0740	serine-type endopeptidase activity
TthTMY_15960	COG0544	peptidyl-prolyl cis-trans isomerase activity
TthTMY_15980	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
TthTMY_15990	COG3870	Protein conserved in bacteria
TthTMY_16010	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
TthTMY_16020	COG1293	RNA-binding protein homologous to eukaryotic snRNP
TthTMY_16030	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
TthTMY_16040	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
TthTMY_16070	COG1960	acyl-CoA dehydrogenase activity
TthTMY_16140	COG2030	dehydratase
TthTMY_16140	COG1012	belongs to the aldehyde dehydrogenase family
TthTMY_16160	COG0318	PFAM AMP-dependent synthetase and ligase
TthTMY_16170	COG1028	Short-chain dehydrogenase reductase Sdr
TthTMY_16200	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
TthTMY_16210	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
TthTMY_16220	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
TthTMY_16260	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
TthTMY_16270	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
TthTMY_16380	COG4475	Protein of unknown function (DUF436)
TthTMY_16410	COG3842	ATPase activity
TthTMY_16420	COG0572	uridine kinase
TthTMY_16470	COG0154	amidase activity
TthTMY_16480	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
TthTMY_16500	COG2133	pyrroloquinoline quinone binding
TthTMY_16520	COG1063	alcohol dehydrogenase
TthTMY_16550	COG1254	Belongs to the acylphosphatase family
TthTMY_16560	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
TthTMY_16590	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
TthTMY_16600	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
TthTMY_16630	COG0183	Belongs to the thiolase family
TthTMY_16640	COG0114	fumarate hydratase activity
TthTMY_16650	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
TthTMY_16660	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
TthTMY_16670	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
TthTMY_16690	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
TthTMY_16710	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
TthTMY_16730	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
TthTMY_16730	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
TthTMY_16770	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
TthTMY_16790	COG0423	glycine-tRNA ligase activity
TthTMY_16800	COG0542	response to heat
TthTMY_16810	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
TthTMY_16820	COG4956	integral membrane protein (PIN domain superfamily)
TthTMY_16890	COG2813	Specifically methylates the guanine in position
TthTMY_16900	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
TthTMY_16950	COG0196	riboflavin kinase activity
TthTMY_16960	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
TthTMY_16970	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
TthTMY_16980	COG0509	glycine decarboxylation via glycine cleavage system
TthTMY_16990	COG0404	The glycine cleavage system catalyzes the degradation of glycine
TthTMY_17020	COG0281	malic enzyme
TthTMY_17030	COG2151	metal-sulfur cluster biosynthetic enzyme
TthTMY_17040	COG0861	Integral membrane protein TerC family
TthTMY_17120	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
TthTMY_17130	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
TthTMY_17150	COG0789	Transcriptional regulator
TthTMY_17160	COG1414	Transcriptional regulator
TthTMY_17170	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
TthTMY_17180	COG0277	FAD linked oxidase domain protein
TthTMY_17190	COG0277	FAD linked oxidase domain protein
TthTMY_17200	COG0247	lactate metabolic process
TthTMY_17260	COG0635	Involved in the biosynthesis of porphyrin-containing compound
TthTMY_17320	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
TthTMY_17340	COG0460	homoserine dehydrogenase
TthTMY_17360	COG3744	PilT protein domain protein
TthTMY_17370	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
TthTMY_17390	COG0815	Transfers the fatty acyl group on membrane lipoproteins
TthTMY_17400	COG2226	methyltransferase
TthTMY_17410	COG2226	methyltransferase
TthTMY_17420	COG0366	Alpha amylase catalytic
TthTMY_17440	COG0037	tRNA processing
TthTMY_17450	COG2104	thiamine diphosphate biosynthetic process
TthTMY_17460	COG0123	including yeast histone deacetylase and acetoin utilization protein
TthTMY_17470	COG0517	IMP dehydrogenase activity
TthTMY_17500	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
TthTMY_17510	COG0601	transmembrane transport
TthTMY_17520	COG0747	negative chemotaxis
TthTMY_17530	COG0604	alcohol dehydrogenase
TthTMY_17530	COG1028	Short-chain dehydrogenase reductase Sdr
TthTMY_17530	COG3321	synthase
TthTMY_17540	COG0492	ferredoxin-NADP+ reductase activity
TthTMY_17590	COG1028	Short-chain dehydrogenase reductase Sdr
TthTMY_17610	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
TthTMY_17610	COG1213	nucleotidyl transferase
TthTMY_17620	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
TthTMY_17630	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
TthTMY_17640	COG1104	cysteine desulfurase activity
TthTMY_17650	COG1959	2 iron, 2 sulfur cluster binding
TthTMY_17660	COG1108	ABC-type Mn2 Zn2 transport systems permease components
TthTMY_17670	COG1121	(ABC) transporter
TthTMY_17720	COG1022	Amp-dependent synthetase and ligase
TthTMY_17770	COG0594	ribonuclease P activity
TthTMY_17780	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
TthTMY_17790	COG0706	membrane insertase activity
TthTMY_17840	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
TthTMY_17870	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
TthTMY_17900	COG0517	IMP dehydrogenase activity
TthTMY_17900	COG0516	GMP reductase activity
TthTMY_17910	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
TthTMY_17920	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
TthTMY_17930	COG0131	Imidazoleglycerol-phosphate dehydratase
TthTMY_17940	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
TthTMY_17950	COG0778	Nitroreductase
TthTMY_18020	COG0333	Belongs to the bacterial ribosomal protein bL32 family
TthTMY_18030	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
TthTMY_18040	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
TthTMY_18060	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
TthTMY_18070	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
TthTMY_18080	COG0232	Belongs to the dGTPase family. Type 2 subfamily
TthTMY_18090	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
TthTMY_18110	COG0564	pseudouridine synthase activity
TthTMY_18120	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
TthTMY_18130	COG2255	four-way junction helicase activity
TthTMY_18190	COG1063	alcohol dehydrogenase
TthTMY_18300	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
TthTMY_18300	COG1605	Chorismate mutase
TthTMY_18310	COG0805	protein transport
TthTMY_18320	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
TthTMY_18330	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
TthTMY_18340	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
TthTMY_18400	COG0395	ABC-type sugar transport system, permease component
TthTMY_18410	COG1175	transmembrane transport
TthTMY_18440	COG1028	Short-chain dehydrogenase reductase Sdr
TthTMY_18450	COG0492	ferredoxin-NADP+ reductase activity
TthTMY_18470	COG0792	nuclease activity
TthTMY_18480	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
TthTMY_18540	COG0220	tRNA (guanine-N7-)-methyltransferase activity
TthTMY_18610	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
TthTMY_18630	COG0142	geranyltranstransferase activity
TthTMY_18660	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
TthTMY_18670	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
TthTMY_18690	COG0297	glycogen (starch) synthase activity
TthTMY_18700	COG2105	PFAM AIG2 family protein
TthTMY_18710	COG0745	RESPONSE REGULATOR receiver
TthTMY_18730	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
TthTMY_18740	COG1067	ATP-dependent peptidase activity
TthTMY_18800	COG0667	Aldo Keto reductase
TthTMY_18880	COG0277	FAD linked oxidase domain protein
TthTMY_18900	COG0227	Belongs to the bacterial ribosomal protein bL28 family
TthTMY_18920	COG0569	domain protein
TthTMY_18920	COG0475	glutathione-regulated potassium exporter activity
TthTMY_18940	COG0436	Aminotransferase
TthTMY_18950	COG1597	lipid kinase activity
TthTMY_18980	COG0123	including yeast histone deacetylase and acetoin utilization protein
TthTMY_19000	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
TthTMY_19020	COG0004	ammonium transporteR
TthTMY_19030	COG0347	Belongs to the P(II) protein family
TthTMY_19040	COG1420	regulation of RNA biosynthetic process
TthTMY_19050	COG0314	molybdopterin synthase activity
TthTMY_19080	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
TthTMY_19100	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
TthTMY_19120	COG0277	FAD linked oxidase domain protein
TthTMY_19170	COG1126	abc transporter atp-binding protein
TthTMY_19180	COG2720	vancomycin resistance protein
TthTMY_19200	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
TthTMY_19220	COG0135	phosphoribosylanthranilate isomerase activity
TthTMY_19270	COG4712	double-strand break repair protein
TthTMY_19290	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
TthTMY_19300	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
TthTMY_19310	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
TthTMY_19320	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
TthTMY_19330	COG0649	NAD binding
TthTMY_19340	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
TthTMY_19350	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
TthTMY_19360	COG1034	ATP synthesis coupled electron transport
TthTMY_19370	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
TthTMY_19380	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
TthTMY_19390	COG0839	Belongs to the complex I subunit 6 family
TthTMY_19400	COG0713	ATP synthesis coupled electron transport
TthTMY_19410	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
TthTMY_19420	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
TthTMY_19430	COG1007	ATP synthesis coupled electron transport
TthTMY_19440	COG0018	arginyl-trna synthetase
TthTMY_19450	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
TthTMY_19460	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
TthTMY_19490	COG2070	2-Nitropropane dioxygenase
TthTMY_19500	COG0463	Glycosyl transferase, family 2
TthTMY_19520	COG0745	RESPONSE REGULATOR receiver
TthTMY_19530	COG2205	protein histidine kinase activity
TthTMY_19560	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
TthTMY_19580	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
TthTMY_19590	COG0582	viral genome integration into host DNA
TthTMY_19700	COG4983	Phage plasmid primase, P4 family domain protein
TthTMY_19750	COG0513	Belongs to the DEAD box helicase family
TthTMY_19780	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
TthTMY_19830	COG0442	prolyl-tRNA aminoacylation
TthTMY_19840	COG3635	2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity
TthTMY_19860	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
TthTMY_19880	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
TthTMY_19890	COG0758	DNA mediated transformation
TthTMY_19890	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
TthTMY_19900	COG3546	catalase activity
TthTMY_19910	COG0583	DNA-binding transcription factor activity
TthTMY_19950	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
TthTMY_19960	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
TthTMY_19970	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
TthTMY_19990	COG0717	Belongs to the dCTP deaminase family
TthTMY_20020	COG0300	oxidoreductase activity
TthTMY_20030	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
TthTMY_20070	COG0515	serine threonine protein kinase
TthTMY_20070	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
TthTMY_20090	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
TthTMY_20110	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
TthTMY_20120	COG0704	Plays a role in the regulation of phosphate uptake
TthTMY_20130	COG4191	Histidine kinase
TthTMY_20140	COG0745	RESPONSE REGULATOR receiver
TthTMY_20150	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
TthTMY_20160	COG1187	pseudouridine synthase activity
TthTMY_20180	COG2414	aldehyde ferredoxin oxidoreductase
TthTMY_20230	COG1902	pentaerythritol trinitrate reductase activity
TthTMY_20270	COG0495	leucyl-tRNA aminoacylation
TthTMY_20280	COG0539	negative regulation of cytoplasmic translation
TthTMY_20310	COG0442	prolyl-tRNA aminoacylation
TthTMY_20360	COG1115	amino acid carrier protein
TthTMY_20400	COG1489	DNA binding
TthTMY_20450	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
TthTMY_20490	COG0432	Pfam Uncharacterised protein family UPF0047
TthTMY_20500	COG3253	May function as heme-dependent peroxidase
TthTMY_20510	COG0668	transmembrane transport
TthTMY_20530	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
TthTMY_20540	COG2217	Heavy metal translocating P-type atpase
TthTMY_20590	COG5002	protein histidine kinase activity
TthTMY_20640	COG2226	methyltransferase
TthTMY_20680	COG2132	Multicopper oxidase
TthTMY_20690	COG2132	Multicopper oxidase
TthTMY_20710	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
TthTMY_20720	COG0822	iron-sulfur transferase activity
TthTMY_20760	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
TthTMY_20780	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
TthTMY_20790	COG0284	orotidine-5'-phosphate decarboxylase activity
TthTMY_20800	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
TthTMY_20820	COG0416	fatty acid biosynthetic process
TthTMY_20830	COG3118	belongs to the thioredoxin family
TthTMY_20840	COG1185	polyribonucleotide nucleotidyltransferase activity
TthTMY_20850	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
TthTMY_20870	COG0438	transferase activity, transferring glycosyl groups
TthTMY_20910	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
TthTMY_20940	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
TthTMY_21020	COG0437	4 iron, 4 sulfur cluster binding
TthTMY_21050	COG0825	malonyl-CoA metabolic process
TthTMY_21060	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
TthTMY_21130	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
TthTMY_21180	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
TthTMY_21190	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
TthTMY_21200	COG0211	Belongs to the bacterial ribosomal protein bL27 family
TthTMY_21210	COG0261	This protein binds to 23S rRNA in the presence of protein L20
TthTMY_21260	COG1518	maintenance of DNA repeat elements
TthTMY_21400	COG0315	cyclic pyranopterin monophosphate synthase activity
TthTMY_21410	COG2860	membrane
TthTMY_21420	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
TthTMY_21470	COG1694	Mazg nucleotide pyrophosphohydrolase
TthTMY_21480	COG1803	Methylglyoxal synthase
TthTMY_21500	COG0301	tRNA thio-modification
TthTMY_21510	COG0154	amidase activity
TthTMY_21520	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
TthTMY_21560	COG2154	pterin-4-alpha-carbinolamine dehydratase
TthTMY_21570	COG1607	acyl-coa hydrolase
TthTMY_21590	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
TthTMY_21600	COG4149	molybdate abc transporter
TthTMY_21610	COG1840	ABC-type Fe3 transport system, periplasmic component
TthTMY_21640	COG0235	Class ii aldolase
TthTMY_21650	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
TthTMY_21660	COG0085	RNA polymerase activity
TthTMY_21680	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
TthTMY_21690	COG1077	Cell shape determining protein MreB Mrl
TthTMY_21700	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
TthTMY_21700	COG1418	mRNA catabolic process
TthTMY_21710	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
TthTMY_21720	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
TthTMY_21730	COG1546	Belongs to the CinA family
TthTMY_21730	COG1058	Belongs to the CinA family
TthTMY_21740	COG0354	folic acid binding
TthTMY_21770	COG4948	Mandelate Racemase Muconate Lactonizing
TthTMY_21800	COG1175	transmembrane transport
TthTMY_21820	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
TthTMY_21840	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
TthTMY_21860	COG0577	efflux transmembrane transporter activity
TthTMY_21870	COG4181	ATPase activity
TthTMY_21880	COG0446	pyridine nucleotide-disulphide oxidoreductase
TthTMY_21920	COG0396	ATPase activity
TthTMY_21930	COG0719	Fe-S assembly protein
TthTMY_21940	COG0719	Fe-S assembly protein
TthTMY_21950	COG2146	nitrite reductase [NAD(P)H] activity
TthTMY_21970	COG0512	Glutamine amidotransferase of anthranilate synthase
TthTMY_21980	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
TthTMY_22020	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
TthTMY_22030	COG2226	methyltransferase
TthTMY_22040	COG4603	Belongs to the binding-protein-dependent transport system permease family
TthTMY_22050	COG1079	Belongs to the binding-protein-dependent transport system permease family
TthTMY_22080	COG1774	PSP1 C-terminal conserved region
TthTMY_22090	COG0470	DNA polymerase III
TthTMY_22180	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
TthTMY_22190	COG0302	gtp cyclohydrolase
TthTMY_22240	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
TthTMY_22260	COG0395	ABC-type sugar transport system, permease component
TthTMY_22270	COG1804	L-carnitine dehydratase bile acid-inducible protein F
TthTMY_22280	COG1131	(ABC) transporter
TthTMY_22320	COG0556	nucleotide-excision repair
TthTMY_22330	COG0497	DNA recombination
TthTMY_22340	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
TthTMY_22350	COG0445	tRNA wobble uridine modification
TthTMY_22400	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
TthTMY_22400	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
TthTMY_22410	COG1543	Belongs to the glycosyl hydrolase 57 family
TthTMY_22420	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
TthTMY_22430	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
TthTMY_22450	COG0189	ligase activity
TthTMY_22480	COG0066	3-isopropylmalate dehydratase activity
TthTMY_22490	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
TthTMY_22520	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
TthTMY_22530	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
TthTMY_22540	COG1960	acyl-CoA dehydrogenase activity
TthTMY_22550	COG0163	prenyltransferase activity
TthTMY_22610	COG4555	ABC transporter
TthTMY_22630	COG2096	Adenosyltransferase
TthTMY_22660	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
TthTMY_22670	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
TthTMY_22700	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
TthTMY_22710	COG0723	plastoquinol--plastocyanin reductase activity
TthTMY_22760	COG1653	transport
TthTMY_22770	COG0820	rRNA (adenine-C2-)-methyltransferase activity
TthTMY_22780	COG1960	acyl-CoA dehydrogenase activity
TthTMY_22800	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
TthTMY_22850	COG0393	Putative heavy-metal-binding
TthTMY_22870	COG3956	TIGRFAM MazG family protein
TthTMY_22900	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
TthTMY_22920	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
TthTMY_22930	COG1937	Protein conserved in bacteria
TthTMY_22950	COG0674	pyruvate-flavodoxin oxidoreductase activity
TthTMY_22950	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
TthTMY_22960	COG1013	pyruvate-flavodoxin oxidoreductase activity
TthTMY_22970	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
TthTMY_22990	COG0072	phenylalanine-tRNA ligase activity
TthTMY_22990	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
TthTMY_23010	COG0205	6-phosphofructokinase activity
TthTMY_23020	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
TthTMY_23040	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
TthTMY_23070	COG0658	competence protein
TthTMY_23070	COG2333	competence protein COMEC
TthTMY_23080	COG1475	DNA binding
TthTMY_23090	COG1192	Involved in chromosome partitioning
TthTMY_23100	COG0357	Ribosomal RNA small subunit methyltransferase G
TthTMY_23150	COG4974	Belongs to the 'phage' integrase family
TthTMY_23210	COG2205	protein histidine kinase activity
TthTMY_23220	COG0745	RESPONSE REGULATOR receiver
TthTMY_t00200	COG0544	peptidyl-prolyl cis-trans isomerase activity