locus-tag	class	description
TTMY_0009	COG0723	plastoquinol--plastocyanin reductase activity
TTMY_0010	COG0243	molybdopterin cofactor binding
TTMY_0012	COG3335	DDE superfamily endonuclease
TTMY_0016	COG3345	alpha-galactosidase
TTMY_0017	COG1085	galactose-1-phosphate uridylyltransferase
TTMY_0022	COG1304	FMN binding
TTMY_0033	COG1562	ergosterol biosynthetic process
TTMY_0035	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
TTMY_0039	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
TTMY_0041	COG1028	Short-chain dehydrogenase reductase Sdr
TTMY_0044	COG1028	Short-chain dehydrogenase reductase Sdr
TTMY_0045	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
TTMY_0047	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
TTMY_0048	COG1414	Transcriptional regulator
TTMY_0051	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
TTMY_0054	COG0803	Belongs to the bacterial solute-binding protein 9 family
TTMY_0062	COG1492	cobalamin metabolic process
TTMY_0066	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
TTMY_0068	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
TTMY_0069	COG0778	Nitroreductase
TTMY_0079	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
TTMY_0080	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
TTMY_0090	COG1797	cobyrinic acid a,c-diamide synthase activity
TTMY_0094	COG2211	Major facilitator Superfamily
TTMY_0101	COG2211	Major facilitator Superfamily
TTMY_0109	COG1337	RAMP superfamily
TTMY_0116	COG1518	maintenance of DNA repeat elements
TTMY_0123	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
TTMY_0130	COG1802	Transcriptional regulator
TTMY_0132	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
TTMY_0143	COG2084	Dehydrogenase
TTMY_0147	COG1942	4-Oxalocrotonate Tautomerase
TTMY_0149	COG1012	belongs to the aldehyde dehydrogenase family
TTMY_0162	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
TTMY_0164	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
TTMY_0165	COG0134	indole-3-glycerol-phosphate synthase activity
TTMY_0167	COG3311	Transcriptional regulator
TTMY_0168	COG1752	Esterase of the alpha-beta hydrolase superfamily
TTMY_0170	COG1126	abc transporter atp-binding protein
TTMY_0174	COG2873	o-acetylhomoserine
TTMY_0175	COG2309	aminopeptidase activity
TTMY_0179	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
TTMY_0179	COG1796	DNA polymerase
TTMY_0180	COG1573	uracil-dna glycosylase
TTMY_0182	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
TTMY_0184	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
TTMY_0185	COG2086	electron transfer activity
TTMY_0186	COG1960	acyl-CoA dehydrogenase activity
TTMY_0187	COG5002	protein histidine kinase activity
TTMY_0188	COG0745	RESPONSE REGULATOR receiver
TTMY_0189	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
TTMY_0190	COG2239	Acts as a magnesium transporter
TTMY_0191	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
TTMY_0192	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
TTMY_0193	COG1185	polyribonucleotide nucleotidyltransferase activity
TTMY_0194	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
TTMY_0196	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
TTMY_0197	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
TTMY_0199	COG1100	Small GTP-binding protein
TTMY_0202	COG0010	Belongs to the arginase family
TTMY_0206	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
TTMY_0207	COG0511	ligase activity, forming carbon-carbon bonds
TTMY_0208	COG0439	Biotin carboxylase
TTMY_0210	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
TTMY_0211	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
TTMY_0212	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
TTMY_0214	COG0247	lactate metabolic process
TTMY_0214	COG2181	nitrate reductase activity
TTMY_0216	COG0861	Integral membrane protein TerC family
TTMY_0218	COG0039	L-malate dehydrogenase activity
TTMY_0220	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
TTMY_0221	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
TTMY_0222	COG0438	transferase activity, transferring glycosyl groups
TTMY_0236	COG1744	ABC transporter substrate-binding protein PnrA-like
TTMY_0237	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
TTMY_0238	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
TTMY_0239	COG0133	tryptophan synthase activity
TTMY_0240	COG0159	tryptophan synthase activity
TTMY_0241	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
TTMY_0243	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
TTMY_0247	COG0812	UDP-N-acetylmuramate dehydrogenase activity
TTMY_0248	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
TTMY_0249	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
TTMY_0250	COG0772	Belongs to the SEDS family
TTMY_0251	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
TTMY_0252	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
TTMY_0253	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
TTMY_0255	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
TTMY_0256	COG0768	penicillin binding
TTMY_0258	COG0275	rRNA processing
TTMY_0259	COG2001	Belongs to the MraZ family
TTMY_0261	COG0254	rRNA binding
TTMY_0262	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
TTMY_0267	COG0006	proline dipeptidase activity
TTMY_0268	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
TTMY_0269	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
TTMY_0270	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
TTMY_0271	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
TTMY_0271	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
TTMY_0274	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
TTMY_0274	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
TTMY_0276	COG2304	oxidoreductase activity
TTMY_0277	COG2239	Acts as a magnesium transporter
TTMY_0278	COG1397	ADP-ribosylglycohydrolase
TTMY_0279	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
TTMY_0281	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
TTMY_0283	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
TTMY_0283	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
TTMY_0287	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
TTMY_0289	COG4864	UPF0365 protein
TTMY_0291	COG1702	phosphate starvation-inducible protein PhoH
TTMY_0292	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
TTMY_0293	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
TTMY_0297	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
TTMY_0298	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
TTMY_0299	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
TTMY_0307	COG0228	four-way junction DNA binding
TTMY_0308	COG1837	Belongs to the UPF0109 family
TTMY_0309	COG0336	Belongs to the RNA methyltransferase TrmD family
TTMY_0310	COG0335	large ribosomal subunit rRNA binding
TTMY_0311	COG2197	response regulator
TTMY_0312	COG1760	l-serine dehydratase
TTMY_0313	COG2897	thiosulfate sulfurtransferase activity
TTMY_0315	COG0582	viral genome integration into host DNA
TTMY_0320	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
TTMY_0329	COG0577	efflux transmembrane transporter activity
TTMY_0329	COG1136	(ABC) transporter
TTMY_0330	COG1136	(ABC) transporter
TTMY_0331	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
TTMY_0334	COG2205	protein histidine kinase activity
TTMY_0335	COG0745	RESPONSE REGULATOR receiver
TTMY_0344	COG1012	belongs to the aldehyde dehydrogenase family
TTMY_0350	COG3335	DDE superfamily endonuclease
TTMY_0357	COG0477	Major facilitator Superfamily
TTMY_0358	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
TTMY_0359	COG1984	allophanate hydrolase subunit 2
TTMY_0360	COG0183	Belongs to the thiolase family
TTMY_0361	COG1331	Highly conserved protein containing a thioredoxin domain
TTMY_0365	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
TTMY_0366	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
TTMY_0367	COG2193	ferroxidase activity
TTMY_0368	COG1733	regulation of RNA biosynthetic process
TTMY_0369	COG1980	fructose-bisphosphate aldolase activity
TTMY_0372	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
TTMY_0374	COG3396	Phenylacetate-CoA oxygenase
TTMY_0375	COG3396	Phenylacetate-CoA oxygenase
TTMY_0379	COG2030	dehydratase
TTMY_0379	COG1012	belongs to the aldehyde dehydrogenase family
TTMY_0380	COG2030	dehydratase
TTMY_0380	COG1012	belongs to the aldehyde dehydrogenase family
TTMY_0382	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
TTMY_0383	COG2050	protein possibly involved in aromatic compounds catabolism
TTMY_0384	COG0410	ABC transporter
TTMY_0385	COG0411	ABC transporter
TTMY_0386	COG0559	Belongs to the binding-protein-dependent transport system permease family
TTMY_0389	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
TTMY_0390	COG2368	4-hydroxyphenylacetate
TTMY_0391	COG2368	4-hydroxyphenylacetate
TTMY_0392	COG1012	belongs to the aldehyde dehydrogenase family
TTMY_0393	COG1012	belongs to the aldehyde dehydrogenase family
TTMY_0395	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
TTMY_0397	COG3769	mannosylglycerate metabolic process
TTMY_0399	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
TTMY_0400	COG1307	EDD domain protein, DegV family
TTMY_0401	COG1307	EDD domain protein, DegV family
TTMY_0402	COG1490	D-aminoacyl-tRNA deacylase activity
TTMY_0403	COG3239	Fatty acid desaturase
TTMY_0404	COG0149	triose-phosphate isomerase activity
TTMY_0417	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
TTMY_0420	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
TTMY_0421	COG0138	bifunctional purine biosynthesis protein purh
TTMY_0423	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
TTMY_0424	COG0742	ribosomal rna small subunit methyltransferase
TTMY_0427	COG0237	dephospho-CoA kinase activity
TTMY_0429	COG1355	regulation of microtubule-based process
TTMY_0431	COG0557	exoribonuclease II activity
TTMY_0434	COG0824	Thioesterase
TTMY_0435	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
TTMY_0436	COG0126	phosphoglycerate kinase activity
TTMY_0438	COG1268	BioY protein
TTMY_0440	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
TTMY_0445	COG1196	nuclear chromosome segregation
TTMY_0445	COG1196	nuclear chromosome segregation
TTMY_0449	COG2738	Putative neutral zinc metallopeptidase
TTMY_0451	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
TTMY_0452	COG0215	cysteine-tRNA ligase activity
TTMY_0453	COG1960	acyl-CoA dehydrogenase activity
TTMY_0454	COG0183	Belongs to the thiolase family
TTMY_0455	COG1250	3-hydroxyacyl-CoA dehydrogenase
TTMY_0455	COG1024	Enoyl-CoA hydratase
TTMY_0458	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
TTMY_0459	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
TTMY_0461	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
TTMY_0462	COG0438	transferase activity, transferring glycosyl groups
TTMY_0464	COG1215	transferase activity, transferring glycosyl groups
TTMY_0466	COG1215	transferase activity, transferring glycosyl groups
TTMY_0469	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
TTMY_0469	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
TTMY_0471	COG1811	Na channel or pump
TTMY_0472	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
TTMY_0473	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
TTMY_0474	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
TTMY_0475	COG4948	Mandelate Racemase Muconate Lactonizing
TTMY_0477	COG0402	S-adenosylhomocysteine deaminase activity
TTMY_0481	COG1012	belongs to the aldehyde dehydrogenase family
TTMY_0482	COG1012	belongs to the aldehyde dehydrogenase family
TTMY_0484	COG0494	nUDIX hydrolase
TTMY_0487	COG0052	Belongs to the universal ribosomal protein uS2 family
TTMY_0488	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
TTMY_0489	COG0528	UMP kinase activity
TTMY_0490	COG0233	cytoplasmic translational termination
TTMY_0491	COG0575	Belongs to the CDS family
TTMY_0492	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
TTMY_0493	COG0750	zinc metalloprotease
TTMY_0494	COG0463	Glycosyl transferase, family 2
TTMY_0496	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
TTMY_0497	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
TTMY_0498	COG2359	stage V sporulation protein S
TTMY_0500	COG2137	regulation of response to DNA damage stimulus
TTMY_0507	COG2766	serine protein kinase
TTMY_0508	COG2718	Belongs to the UPF0229 family
TTMY_0509	COG2719	SpoVR family
TTMY_0510	COG2719	SpoVR family
TTMY_0511	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
TTMY_0512	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
TTMY_0515	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
TTMY_0517	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
TTMY_0518	COG1994	Peptidase M50
TTMY_0520	COG0617	tRNA 3'-terminal CCA addition
TTMY_0523	COG0517	IMP dehydrogenase activity
TTMY_0526	COG1674	ftsk spoiiie
TTMY_0528	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
TTMY_0529	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
TTMY_0530	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
TTMY_0530	COG4651	solute:proton antiporter activity
TTMY_0531	COG0217	transcriptional regulatory protein
TTMY_0533	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
TTMY_0541	COG2176	DNA-directed DNA polymerase activity
TTMY_0541	COG5002	protein histidine kinase activity
TTMY_0542	COG0151	Belongs to the GarS family
TTMY_0543	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
TTMY_0545	COG0179	Fumarylacetoacetate (FAA) hydrolase
TTMY_0546	COG0179	Fumarylacetoacetate (FAA) hydrolase
TTMY_0548	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
TTMY_0553	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
TTMY_0555	COG1427	Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
TTMY_0556	COG2353	YceI-like domain
TTMY_0558	COG2514	catechol 2,3-dioxygenase activity
TTMY_0559	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
TTMY_0560	COG0287	Prephenate dehydrogenase
TTMY_0561	COG5001	Diguanylate cyclase
TTMY_0561	COG3300	MHYT domain
TTMY_0562	COG0277	FAD linked oxidase domain protein
TTMY_0567	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
TTMY_0569	COG0456	acetyltransferase
TTMY_0570	COG1960	acyl-CoA dehydrogenase activity
TTMY_0573	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
TTMY_0574	COG0730	response to heat
TTMY_0579	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
TTMY_0581	COG0167	dihydroorotate dehydrogenase activity
TTMY_0583	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
TTMY_0584	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
TTMY_0585	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
TTMY_0586	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
TTMY_0598	COG1063	alcohol dehydrogenase
TTMY_0601	COG3335	DDE superfamily endonuclease
TTMY_0603	COG2873	o-acetylhomoserine
TTMY_0604	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
TTMY_0607	COG1073	alpha beta
TTMY_0608	COG0405	Gamma-glutamyltransferase
TTMY_0613	COG1028	Short-chain dehydrogenase reductase Sdr
TTMY_0616	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
TTMY_0622	COG0481	GTPase activity
TTMY_0624	COG1760	l-serine dehydratase
TTMY_0626	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
TTMY_0638	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
TTMY_0642	COG1316	TRANSCRIPTIONal
TTMY_0645	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
TTMY_0646	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
TTMY_0650	COG1573	uracil-dna glycosylase
TTMY_0653	COG3842	ATPase activity
TTMY_0655	COG0124	histidyl-tRNA synthetase
TTMY_0656	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
TTMY_0657	COG0384	phenazine biosynthesis protein PhzF
TTMY_0658	COG0384	phenazine biosynthesis protein PhzF
TTMY_0659	COG0561	phosphatase activity
TTMY_0660	COG0017	Asparaginyl-tRNA synthetase
TTMY_0661	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
TTMY_0662	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
TTMY_0663	COG2217	Heavy metal translocating P-type atpase
TTMY_0665	COG2217	Heavy metal translocating P-type atpase
TTMY_0666	COG0640	Transcriptional regulator
TTMY_0667	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
TTMY_0668	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
TTMY_0671	COG0779	Required for maturation of 30S ribosomal subunits
TTMY_0672	COG0195	Participates in both transcription termination and antitermination
TTMY_0673	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
TTMY_0675	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
TTMY_0675	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
TTMY_0676	COG1028	Short-chain dehydrogenase reductase Sdr
TTMY_0679	COG0183	Belongs to the thiolase family
TTMY_0681	COG1940	carbohydrate kinase activity
TTMY_0687	COG0477	Major facilitator Superfamily
TTMY_0688	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
TTMY_0689	COG2022	thiamine diphosphate biosynthetic process
TTMY_0689	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
TTMY_0690	COG2022	thiamine diphosphate biosynthetic process
TTMY_0691	COG2104	thiamine diphosphate biosynthetic process
TTMY_0692	COG0352	thiamine-phosphate diphosphorylase activity
TTMY_0694	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
TTMY_0695	COG1587	Uroporphyrinogen-III synthase
TTMY_0696	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
TTMY_0696	COG1648	precorrin-2 dehydrogenase activity
TTMY_0697	COG0175	sulfate reduction
TTMY_0700	COG1648	precorrin-2 dehydrogenase activity
TTMY_0700	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
TTMY_0701	COG2046	Belongs to the sulfate adenylyltransferase family
TTMY_0702	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
TTMY_0704	COG0574	Belongs to the PEP-utilizing enzyme family
TTMY_0704	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
TTMY_0705	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
TTMY_0705	COG0574	Belongs to the PEP-utilizing enzyme family
TTMY_0712	COG1385	rRNA (uridine-N3-)-methyltransferase activity
TTMY_0713	COG2264	protein methyltransferase activity
TTMY_0715	COG0489	protein tyrosine kinase activity
TTMY_0716	COG0489	protein tyrosine kinase activity
TTMY_0720	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
TTMY_0721	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
TTMY_0722	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
TTMY_0725	COG1215	transferase activity, transferring glycosyl groups
TTMY_0726	COG0438	transferase activity, transferring glycosyl groups
TTMY_0726	COG0297	glycogen (starch) synthase activity
TTMY_0727	COG0438	transferase activity, transferring glycosyl groups
TTMY_0729	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
TTMY_0732	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
TTMY_0745	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
TTMY_0746	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
TTMY_0752	COG0582	viral genome integration into host DNA
TTMY_0755	COG2189	Belongs to the N(4) N(6)-methyltransferase family
TTMY_0772	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
TTMY_0773	COG1692	metallophosphoesterase
TTMY_0776	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
TTMY_0778	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
TTMY_0781	COG0646	methionine synthase
TTMY_0781	COG1410	methionine synthase
TTMY_0782	COG0646	methionine synthase
TTMY_0782	COG1410	methionine synthase
TTMY_0783	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
TTMY_0784	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
TTMY_0785	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
TTMY_0786	COG0740	serine-type endopeptidase activity
TTMY_0787	COG0544	peptidyl-prolyl cis-trans isomerase activity
TTMY_0788	COG0544	peptidyl-prolyl cis-trans isomerase activity
TTMY_0789	COG0544	peptidyl-prolyl cis-trans isomerase activity
TTMY_0793	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
TTMY_0794	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
TTMY_0795	COG3870	Protein conserved in bacteria
TTMY_0797	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
TTMY_0799	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
TTMY_0800	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
TTMY_0803	COG1960	acyl-CoA dehydrogenase activity
TTMY_0807	COG1137	ATPase activity
TTMY_0810	COG1012	belongs to the aldehyde dehydrogenase family
TTMY_0810	COG2030	dehydratase
TTMY_0812	COG0318	PFAM AMP-dependent synthetase and ligase
TTMY_0813	COG1028	Short-chain dehydrogenase reductase Sdr
TTMY_0816	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
TTMY_0817	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
TTMY_0824	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
TTMY_0825	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
TTMY_0828	COG0683	leucine binding
TTMY_0832	COG0318	PFAM AMP-dependent synthetase and ligase
TTMY_0838	COG4475	Protein of unknown function (DUF436)
TTMY_0841	COG3842	ATPase activity
TTMY_0842	COG0572	uridine kinase
TTMY_0848	COG0154	amidase activity
TTMY_0849	COG0154	amidase activity
TTMY_0850	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
TTMY_0851	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
TTMY_0857	COG1063	alcohol dehydrogenase
TTMY_0860	COG1254	Belongs to the acylphosphatase family
TTMY_0861	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
TTMY_0864	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
TTMY_0865	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
TTMY_0870	COG0183	Belongs to the thiolase family
TTMY_0871	COG0114	fumarate hydratase activity
TTMY_0872	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
TTMY_0873	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
TTMY_0875	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
TTMY_0877	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
TTMY_0878	COG0291	Belongs to the bacterial ribosomal protein bL35 family
TTMY_0879	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
TTMY_0883	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
TTMY_0883	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
TTMY_0887	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
TTMY_0890	COG0423	glycine-tRNA ligase activity
TTMY_0891	COG0542	response to heat
TTMY_0892	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
TTMY_0894	COG4956	integral membrane protein (PIN domain superfamily)
TTMY_0895	COG4956	integral membrane protein (PIN domain superfamily)
TTMY_0899	COG0039	L-malate dehydrogenase activity
TTMY_0900	COG0527	aspartate kinase activity
TTMY_0903	COG2813	Specifically methylates the guanine in position
TTMY_0905	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
TTMY_0909	COG1051	belongs to the nudix hydrolase family
TTMY_0910	COG0196	riboflavin kinase activity
TTMY_0911	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
TTMY_0912	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
TTMY_0913	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
TTMY_0914	COG0509	glycine decarboxylation via glycine cleavage system
TTMY_0915	COG0404	The glycine cleavage system catalyzes the degradation of glycine
TTMY_0919	COG0281	malic enzyme
TTMY_0920	COG0281	malic enzyme
TTMY_0921	COG2151	metal-sulfur cluster biosynthetic enzyme
TTMY_0922	COG0861	Integral membrane protein TerC family
TTMY_0929	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
TTMY_0930	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
TTMY_0931	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
TTMY_0932	COG0789	Transcriptional regulator
TTMY_0935	COG0277	FAD linked oxidase domain protein
TTMY_0937	COG0277	FAD linked oxidase domain protein
TTMY_0939	COG0247	lactate metabolic process
TTMY_0945	COG0635	Involved in the biosynthesis of porphyrin-containing compound
TTMY_0953	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
TTMY_0955	COG0460	homoserine dehydrogenase
TTMY_0957	COG3744	PilT protein domain protein
TTMY_0958	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
TTMY_0960	COG0815	Transfers the fatty acyl group on membrane lipoproteins
TTMY_0962	COG2226	methyltransferase
TTMY_0964	COG0366	Alpha amylase catalytic
TTMY_0966	COG0037	tRNA processing
TTMY_0967	COG2104	thiamine diphosphate biosynthetic process
TTMY_0969	COG0123	including yeast histone deacetylase and acetoin utilization protein
TTMY_0970	COG0517	IMP dehydrogenase activity
TTMY_0973	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
TTMY_0974	COG0601	transmembrane transport
TTMY_0975	COG0747	negative chemotaxis
TTMY_0977	COG0492	ferredoxin-NADP+ reductase activity
TTMY_0984	COG1028	Short-chain dehydrogenase reductase Sdr
TTMY_0986	COG1213	nucleotidyl transferase
TTMY_0986	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
TTMY_0987	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
TTMY_0988	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
TTMY_0989	COG1104	cysteine desulfurase activity
TTMY_0990	COG1959	2 iron, 2 sulfur cluster binding
TTMY_0991	COG1108	ABC-type Mn2 Zn2 transport systems permease components
TTMY_0992	COG1121	(ABC) transporter
TTMY_0994	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
TTMY_0998	COG0559	Belongs to the binding-protein-dependent transport system permease family
TTMY_0999	COG1022	Amp-dependent synthetase and ligase
TTMY_1003	COG0594	ribonuclease P activity
TTMY_1004	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
TTMY_1005	COG0706	membrane insertase activity
TTMY_1007	COG2890	protein-(glutamine-N5) methyltransferase activity
TTMY_1010	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
TTMY_1013	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
TTMY_1016	COG0516	GMP reductase activity
TTMY_1016	COG0517	IMP dehydrogenase activity
TTMY_1017	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
TTMY_1018	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
TTMY_1019	COG0131	Imidazoleglycerol-phosphate dehydratase
TTMY_1020	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
TTMY_1021	COG0778	Nitroreductase
TTMY_1029	COG0333	Belongs to the bacterial ribosomal protein bL32 family
TTMY_1030	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
TTMY_1031	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
TTMY_1033	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
TTMY_1034	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
TTMY_1035	COG0232	Belongs to the dGTPase family. Type 2 subfamily
TTMY_1036	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
TTMY_1038	COG0564	pseudouridine synthase activity
TTMY_1039	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
TTMY_1040	COG2255	four-way junction helicase activity
TTMY_1047	COG1063	alcohol dehydrogenase
TTMY_1057	COG3573	Dehydrogenase
TTMY_1059	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
TTMY_1059	COG1605	Chorismate mutase
TTMY_1060	COG0805	protein transport
TTMY_1061	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
TTMY_1062	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
TTMY_1063	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
TTMY_1071	COG1175	transmembrane transport
TTMY_1074	COG1028	Short-chain dehydrogenase reductase Sdr
TTMY_1075	COG0492	ferredoxin-NADP+ reductase activity
TTMY_1077	COG0792	nuclease activity
TTMY_1078	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
TTMY_1084	COG0220	tRNA (guanine-N7-)-methyltransferase activity
TTMY_1094	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
TTMY_1096	COG0142	geranyltranstransferase activity
TTMY_1100	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
TTMY_1101	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
TTMY_1102	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
TTMY_1104	COG0297	glycogen (starch) synthase activity
TTMY_1105	COG2105	PFAM AIG2 family protein
TTMY_1106	COG0745	RESPONSE REGULATOR receiver
TTMY_1108	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
TTMY_1109	COG1067	ATP-dependent peptidase activity
TTMY_1116	COG0667	Aldo Keto reductase
TTMY_1126	COG0277	FAD linked oxidase domain protein
TTMY_1128	COG0227	Belongs to the bacterial ribosomal protein bL28 family
TTMY_1130	COG0475	glutathione-regulated potassium exporter activity
TTMY_1130	COG0569	domain protein
TTMY_1133	COG1597	lipid kinase activity
TTMY_1136	COG0123	including yeast histone deacetylase and acetoin utilization protein
TTMY_1138	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
TTMY_1140	COG0004	ammonium transporteR
TTMY_1141	COG0347	Belongs to the P(II) protein family
TTMY_1142	COG1420	regulation of RNA biosynthetic process
TTMY_1143	COG0314	molybdopterin synthase activity
TTMY_1146	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
TTMY_1148	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
TTMY_1150	COG0277	FAD linked oxidase domain protein
TTMY_1157	COG2720	vancomycin resistance protein
TTMY_1158	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
TTMY_1161	COG0135	phosphoribosylanthranilate isomerase activity
TTMY_1168	COG4712	double-strand break repair protein
TTMY_1170	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
TTMY_1171	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
TTMY_1172	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
TTMY_1173	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
TTMY_1174	COG0649	NAD binding
TTMY_1175	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
TTMY_1176	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
TTMY_1177	COG1034	ATP synthesis coupled electron transport
TTMY_1178	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
TTMY_1179	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
TTMY_1180	COG0839	Belongs to the complex I subunit 6 family
TTMY_1181	COG0713	ATP synthesis coupled electron transport
TTMY_1182	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
TTMY_1183	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
TTMY_1184	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
TTMY_1185	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
TTMY_1186	COG1007	ATP synthesis coupled electron transport
TTMY_1187	COG0018	arginyl-trna synthetase
TTMY_1188	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
TTMY_1189	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
TTMY_1192	COG2070	2-Nitropropane dioxygenase
TTMY_1194	COG0463	Glycosyl transferase, family 2
TTMY_1197	COG0745	RESPONSE REGULATOR receiver
TTMY_1201	COG5002	protein histidine kinase activity
TTMY_1205	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
TTMY_1207	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
TTMY_1209	COG0582	viral genome integration into host DNA
TTMY_1221	COG4983	Phage plasmid primase, P4 family domain protein
TTMY_1226	COG0513	Belongs to the DEAD box helicase family
TTMY_1227	COG0303	'Molybdopterin
TTMY_1230	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
TTMY_1236	COG0442	prolyl-tRNA aminoacylation
TTMY_1237	COG0442	prolyl-tRNA aminoacylation
TTMY_1238	COG3635	2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity
TTMY_1240	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
TTMY_1243	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
TTMY_1244	COG0758	DNA mediated transformation
TTMY_1244	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
TTMY_1245	COG3546	catalase activity
TTMY_1246	COG0583	DNA-binding transcription factor activity
TTMY_1250	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
TTMY_1251	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
TTMY_1252	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
TTMY_1254	COG0717	Belongs to the dCTP deaminase family
TTMY_1257	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
TTMY_1257	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
TTMY_1258	COG1028	Short-chain dehydrogenase reductase Sdr
TTMY_1259	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
TTMY_1266	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
TTMY_1266	COG0515	serine threonine protein kinase
TTMY_1268	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
TTMY_1269	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
TTMY_1271	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
TTMY_1272	COG0704	Plays a role in the regulation of phosphate uptake
TTMY_1273	COG4191	Histidine kinase
TTMY_1274	COG0745	RESPONSE REGULATOR receiver
TTMY_1275	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
TTMY_1276	COG1187	pseudouridine synthase activity
TTMY_1279	COG2414	aldehyde ferredoxin oxidoreductase
TTMY_1284	COG1902	pentaerythritol trinitrate reductase activity
TTMY_1289	COG0495	leucyl-tRNA aminoacylation
TTMY_1290	COG0539	negative regulation of cytoplasmic translation
TTMY_1293	COG0442	prolyl-tRNA aminoacylation
TTMY_1299	COG1115	amino acid carrier protein
TTMY_1300	COG1115	amino acid carrier protein
TTMY_1305	COG1489	DNA binding
TTMY_1317	COG0432	Pfam Uncharacterised protein family UPF0047
TTMY_1319	COG0668	transmembrane transport
TTMY_1322	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
TTMY_1323	COG2217	Heavy metal translocating P-type atpase
TTMY_1328	COG5002	protein histidine kinase activity
TTMY_1333	COG2226	methyltransferase
TTMY_1339	COG2132	Multicopper oxidase
TTMY_1341	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
TTMY_1342	COG0822	iron-sulfur transferase activity
TTMY_1346	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
TTMY_1350	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
TTMY_1351	COG0284	orotidine-5'-phosphate decarboxylase activity
TTMY_1356	COG0416	fatty acid biosynthetic process
TTMY_1357	COG3118	belongs to the thioredoxin family
TTMY_1358	COG1185	polyribonucleotide nucleotidyltransferase activity
TTMY_1359	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
TTMY_1362	COG0438	transferase activity, transferring glycosyl groups
TTMY_1366	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
TTMY_1369	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
TTMY_1377	COG0437	4 iron, 4 sulfur cluster binding
TTMY_1380	COG0825	malonyl-CoA metabolic process
TTMY_1381	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
TTMY_1382	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
TTMY_1389	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
TTMY_1394	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
TTMY_1395	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
TTMY_1396	COG0211	Belongs to the bacterial ribosomal protein bL27 family
TTMY_1397	COG0261	This protein binds to 23S rRNA in the presence of protein L20
TTMY_1404	COG1518	maintenance of DNA repeat elements
TTMY_1421	COG0315	cyclic pyranopterin monophosphate synthase activity
TTMY_1422	COG2860	membrane
TTMY_1423	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
TTMY_1426	COG1694	Mazg nucleotide pyrophosphohydrolase
TTMY_1427	COG1803	Methylglyoxal synthase
TTMY_1429	COG0301	tRNA thio-modification
TTMY_1430	COG0301	tRNA thio-modification
TTMY_1431	COG0154	amidase activity
TTMY_1432	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
TTMY_1437	COG2154	pterin-4-alpha-carbinolamine dehydratase
TTMY_1438	COG1607	acyl-coa hydrolase
TTMY_1440	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
TTMY_1442	COG1840	ABC-type Fe3 transport system, periplasmic component
TTMY_1445	COG0235	Class ii aldolase
TTMY_1446	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
TTMY_1447	COG0085	RNA polymerase activity
TTMY_1449	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
TTMY_1450	COG1077	Cell shape determining protein MreB Mrl
TTMY_1451	COG1418	mRNA catabolic process
TTMY_1451	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
TTMY_1452	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
TTMY_1453	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
TTMY_1454	COG1546	Belongs to the CinA family
TTMY_1454	COG1058	Belongs to the CinA family
TTMY_1455	COG0354	folic acid binding
TTMY_1458	COG4948	Mandelate Racemase Muconate Lactonizing
TTMY_1461	COG1175	transmembrane transport
TTMY_1463	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
TTMY_1465	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
TTMY_1467	COG0577	efflux transmembrane transporter activity
TTMY_1467	COG1136	(ABC) transporter
TTMY_1468	COG0577	efflux transmembrane transporter activity
TTMY_1469	COG4181	ATPase activity
TTMY_1470	COG0446	pyridine nucleotide-disulphide oxidoreductase
TTMY_1474	COG0396	ATPase activity
TTMY_1475	COG0719	Fe-S assembly protein
TTMY_1476	COG0719	Fe-S assembly protein
TTMY_1477	COG2146	nitrite reductase [NAD(P)H] activity
TTMY_1478	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
TTMY_1479	COG0512	Glutamine amidotransferase of anthranilate synthase
TTMY_1480	COG0512	Glutamine amidotransferase of anthranilate synthase
TTMY_1481	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
TTMY_1486	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
TTMY_1487	COG2226	methyltransferase
TTMY_1493	COG1774	PSP1 C-terminal conserved region
TTMY_1494	COG0470	DNA polymerase III
TTMY_1505	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
TTMY_1506	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
TTMY_1507	COG0302	gtp cyclohydrolase
TTMY_1512	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
TTMY_1514	COG0395	ABC-type sugar transport system, permease component
TTMY_1515	COG1804	L-carnitine dehydratase bile acid-inducible protein F
TTMY_1516	COG1131	(ABC) transporter
TTMY_1517	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
TTMY_1521	COG0556	nucleotide-excision repair
TTMY_1522	COG0497	DNA recombination
TTMY_1523	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
TTMY_1525	COG0445	tRNA wobble uridine modification
TTMY_1530	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
TTMY_1530	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
TTMY_1531	COG1543	Belongs to the glycosyl hydrolase 57 family
TTMY_1532	COG1543	Belongs to the glycosyl hydrolase 57 family
TTMY_1533	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
TTMY_1534	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
TTMY_1536	COG0189	ligase activity
TTMY_1539	COG0066	3-isopropylmalate dehydratase activity
TTMY_1540	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
TTMY_1544	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
TTMY_1545	COG1960	acyl-CoA dehydrogenase activity
TTMY_1546	COG0163	prenyltransferase activity
TTMY_1555	COG4555	ABC transporter
TTMY_1557	COG2096	Adenosyltransferase
TTMY_1562	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
TTMY_1563	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
TTMY_1566	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
TTMY_1567	COG0723	plastoquinol--plastocyanin reductase activity
TTMY_1573	COG1653	transport
TTMY_1574	COG0820	rRNA (adenine-C2-)-methyltransferase activity
TTMY_1575	COG1960	acyl-CoA dehydrogenase activity
TTMY_1577	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
TTMY_1582	COG0393	Putative heavy-metal-binding
TTMY_1584	COG3956	TIGRFAM MazG family protein
TTMY_1587	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
TTMY_1588	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
TTMY_1589	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
TTMY_1590	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
TTMY_1592	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
TTMY_1593	COG1937	Protein conserved in bacteria
TTMY_1595	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
TTMY_1595	COG0674	pyruvate-flavodoxin oxidoreductase activity
TTMY_1596	COG1013	pyruvate-flavodoxin oxidoreductase activity
TTMY_1598	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
TTMY_1599	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
TTMY_1600	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
TTMY_1600	COG0072	phenylalanine-tRNA ligase activity
TTMY_1601	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
TTMY_1601	COG0072	phenylalanine-tRNA ligase activity
TTMY_1603	COG0205	6-phosphofructokinase activity
TTMY_1604	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
TTMY_1606	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
TTMY_1609	COG0658	competence protein
TTMY_1609	COG2333	competence protein COMEC
TTMY_1610	COG1475	DNA binding
TTMY_1611	COG1192	Involved in chromosome partitioning
TTMY_1612	COG0357	Ribosomal RNA small subunit methyltransferase G
TTMY_1613	COG0445	tRNA wobble uridine modification
TTMY_1614	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
TTMY_1616	COG0148	phosphopyruvate hydratase activity
TTMY_1617	COG0469	pyruvate kinase activity
TTMY_1621	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
TTMY_1623	COG1842	Phage shock protein A
TTMY_1631	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
TTMY_1632	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
TTMY_1634	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
TTMY_1635	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
TTMY_1637	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
TTMY_1638	COG1278	Cold shock
TTMY_1640	COG1653	transport
TTMY_1643	COG0033	Phosphoglucomutase
TTMY_1646	COG2814	Major facilitator Superfamily
TTMY_1650	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
TTMY_1652	COG0181	hydroxymethylbilane synthase activity
TTMY_1654	COG0285	dihydrofolate synthase activity
TTMY_1655	COG0436	Aminotransferase
TTMY_1656	COG0521	Mo-molybdopterin cofactor biosynthetic process
TTMY_1661	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
TTMY_1662	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
TTMY_1663	COG1993	acr, cog1993
TTMY_1664	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
TTMY_1666	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
TTMY_1668	COG1335	isochorismatase
TTMY_1669	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
TTMY_1672	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
TTMY_1673	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
TTMY_1675	COG0242	peptide deformylase activity
TTMY_1676	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
TTMY_1678	COG1660	Displays ATPase and GTPase activities
TTMY_1679	COG0391	Required for morphogenesis under gluconeogenic growth conditions
TTMY_1690	COG3335	DDE superfamily endonuclease
TTMY_1704	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
TTMY_1705	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
TTMY_1706	COG2226	methyltransferase
TTMY_1711	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
TTMY_1712	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
TTMY_1713	COG0022	dehydrogenase e1 component
TTMY_1714	COG1598	PFAM Uncharacterised protein family UPF0150
TTMY_1717	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
TTMY_1728	COG3335	DDE superfamily endonuclease
TTMY_1730	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
TTMY_1731	COG0321	lipoyl(octanoyl) transferase activity
TTMY_1732	COG0300	oxidoreductase activity
TTMY_1735	COG0359	binds to the 23S rRNA
TTMY_1736	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
TTMY_1737	COG0629	single-stranded DNA binding
TTMY_1738	COG0360	Binds together with S18 to 16S ribosomal RNA
TTMY_1740	COG0081	regulation of translation
TTMY_1741	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
TTMY_1742	COG0250	Participates in transcription elongation, termination and antitermination
TTMY_1743	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
TTMY_1744	COG0267	Belongs to the bacterial ribosomal protein bL33 family
TTMY_1745	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
TTMY_1750	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
TTMY_1753	COG0735	belongs to the Fur family
TTMY_1756	COG0482	sulfurtransferase activity
TTMY_1757	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
TTMY_1758	COG0573	inorganic phosphate transmembrane transporter activity
TTMY_1759	COG0581	inorganic phosphate transmembrane transporter activity
TTMY_1760	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
TTMY_1762	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
TTMY_1764	COG1388	LysM domain
TTMY_1764	COG3942	CHAP domain
TTMY_1769	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
TTMY_1770	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
TTMY_1771	COG0459	protein refolding
TTMY_1772	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
TTMY_1773	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
TTMY_1776	COG0166	Belongs to the GPI family
TTMY_1777	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
TTMY_1780	COG0505	Belongs to the CarA family
TTMY_1782	COG0165	Argininosuccinate lyase
TTMY_1783	COG0137	argininosuccinate synthase activity
TTMY_1784	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
TTMY_1786	COG0508	dehydrogenase complex catalyzes the overall conversion of
TTMY_1789	COG1024	Enoyl-CoA hydratase
TTMY_1790	COG0632	four-way junction helicase activity
TTMY_1793	COG1611	Belongs to the LOG family
TTMY_1794	COG0589	response to stress
TTMY_1795	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
TTMY_1796	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
TTMY_1806	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
TTMY_1807	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
TTMY_1808	COG0343	queuine tRNA-ribosyltransferase activity
TTMY_1811	COG0628	permease
TTMY_1812	COG1612	heme a metabolic process
TTMY_1812	COG0109	protoheme IX farnesyltransferase activity
TTMY_1813	COG0109	protoheme IX farnesyltransferase activity
TTMY_1813	COG1612	heme a metabolic process
TTMY_1814	COG1612	heme a metabolic process
TTMY_1814	COG0109	protoheme IX farnesyltransferase activity
TTMY_1816	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
TTMY_1816	COG1845	cytochrome c oxidase, subunit III
TTMY_1817	COG1845	cytochrome c oxidase, subunit III
TTMY_1817	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
TTMY_1822	COG0582	viral genome integration into host DNA
TTMY_1823	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
TTMY_1828	COG1187	pseudouridine synthase activity
TTMY_1829	COG1024	Enoyl-CoA hydratase
TTMY_1830	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
TTMY_1831	COG0686	Belongs to the AlaDH PNT family
TTMY_1833	COG1461	Dihydroxyacetone kinase
TTMY_1836	COG4591	ABC-type transport system involved in lipoprotein release permease component
TTMY_1837	COG0222	ribosome binding
TTMY_1838	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
TTMY_1839	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
TTMY_1840	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
TTMY_1841	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
TTMY_1847	COG0243	molybdopterin cofactor binding
TTMY_1848	COG0243	molybdopterin cofactor binding
TTMY_1849	COG2272	Belongs to the type-B carboxylesterase lipase family
TTMY_1850	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
TTMY_1852	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
TTMY_1855	COG0477	Major facilitator Superfamily
TTMY_1858	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
TTMY_1860	COG0105	UTP biosynthetic process
TTMY_1861	COG0631	protein serine/threonine phosphatase activity
TTMY_1862	COG0583	DNA-binding transcription factor activity
TTMY_1864	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
TTMY_1865	COG0508	dehydrogenase complex catalyzes the overall conversion of
TTMY_1872	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
TTMY_1874	COG0484	heat shock protein binding
TTMY_1875	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
TTMY_1876	COG1968	undecaprenyl-diphosphatase activity
TTMY_1877	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
TTMY_1878	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
TTMY_1881	COG1309	transcriptional regulator
TTMY_1882	COG4242	Belongs to the peptidase S51 family
TTMY_1885	COG0802	atpase or kinase
TTMY_1887	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
TTMY_1888	COG0049	tRNA binding
TTMY_1889	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
TTMY_1890	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
TTMY_1891	COG0051	transcription antitermination factor activity, RNA binding
TTMY_1892	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
TTMY_1893	COG0088	Forms part of the polypeptide exit tunnel
TTMY_1894	COG0089	rRNA binding
TTMY_1895	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
TTMY_1896	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
TTMY_1897	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
TTMY_1898	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
TTMY_1899	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
TTMY_1900	COG0255	Belongs to the universal ribosomal protein uL29 family
TTMY_1901	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
TTMY_1902	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
TTMY_1903	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
TTMY_1904	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
TTMY_1905	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
TTMY_1906	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
TTMY_1907	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
TTMY_1908	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
TTMY_1909	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
TTMY_1910	COG1841	ribosomal large subunit assembly
TTMY_1911	COG0200	Binds to the 23S rRNA
TTMY_1912	COG0201	protein transport
TTMY_1913	COG0563	adenylate kinase activity
TTMY_1915	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
TTMY_1916	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
TTMY_1917	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
TTMY_1918	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
TTMY_1919	COG0202	RNA polymerase activity
TTMY_1920	COG0203	ribosomal protein L17
TTMY_1931	COG0142	geranyltranstransferase activity
TTMY_1932	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
TTMY_1936	COG1175	transmembrane transport
TTMY_1938	COG3833	ABC-type maltose transport systems, permease component
TTMY_1941	COG0366	Alpha amylase catalytic
TTMY_1943	COG1193	negative regulation of DNA recombination
TTMY_1944	COG1611	Belongs to the LOG family
TTMY_1945	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
TTMY_1946	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
TTMY_1947	COG0745	RESPONSE REGULATOR receiver
TTMY_1947	COG3706	GGDEF domain
TTMY_1948	COG1166	arginine decarboxylase activity
TTMY_1949	COG1166	arginine decarboxylase activity
TTMY_1952	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
TTMY_1953	COG0006	proline dipeptidase activity
TTMY_1954	COG0316	Belongs to the HesB IscA family
TTMY_1955	COG0747	negative chemotaxis
TTMY_1956	COG0601	transmembrane transport
TTMY_1957	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
TTMY_1958	COG0101	tRNA pseudouridine synthase activity
TTMY_1959	COG3842	ATPase activity
TTMY_1961	COG1840	ABC-type Fe3 transport system, periplasmic component
TTMY_1964	COG1764	response to oxidative stress
TTMY_1966	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
TTMY_1967	COG2897	thiosulfate sulfurtransferase activity
TTMY_1969	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
TTMY_1970	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
TTMY_1971	COG0220	tRNA (guanine-N7-)-methyltransferase activity
TTMY_1972	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
TTMY_1973	COG0537	adenosine 5'-monophosphoramidase activity
TTMY_1977	COG1011	Hydrolase
TTMY_1978	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
TTMY_1981	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
TTMY_1982	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
TTMY_1983	COG1506	peptidase
TTMY_1983	COG0823	Involved in the tonB-independent uptake of proteins
TTMY_1983	COG4946	Tricorn protease homolog
TTMY_1987	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
TTMY_1988	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
TTMY_1989	COG0113	porphobilinogen synthase activity
TTMY_1992	COG0631	protein serine/threonine phosphatase activity
TTMY_1993	COG2815	serine threonine protein kinase
TTMY_1993	COG0515	serine threonine protein kinase
TTMY_1999	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
TTMY_2000	COG0193	aminoacyl-tRNA hydrolase activity
TTMY_2001	COG1181	Belongs to the D-alanine--D-alanine ligase family
TTMY_2002	COG0187	DNA topoisomerase II activity
TTMY_2005	COG0732	type I restriction modification DNA specificity domain
TTMY_2005	COG0827	DNA restriction-modification system
TTMY_2006	COG0156	8-amino-7-oxononanoate synthase activity
TTMY_2010	COG0506	proline dehydrogenase activity
TTMY_2011	COG1012	belongs to the aldehyde dehydrogenase family
TTMY_2012	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
TTMY_2013	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
TTMY_2022	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
TTMY_2024	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
TTMY_2025	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
TTMY_2026	COG2385	sporulation resulting in formation of a cellular spore
TTMY_2027	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
TTMY_2029	COG0194	GDP metabolic process
TTMY_2030	COG1758	RNA polymerase activity
TTMY_2031	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
TTMY_2032	COG1438	arginine binding
TTMY_2033	COG2095	MarC family integral membrane protein
TTMY_2034	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
TTMY_2035	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
TTMY_2036	COG0328	RNA-DNA hybrid ribonuclease activity
TTMY_2040	COG4274	PFAM GYD family protein
TTMY_2041	COG4636	protein conserved in cyanobacteria
TTMY_2042	COG0519	Catalyzes the synthesis of GMP from XMP
TTMY_2042	COG0518	GMP synthase (glutamine-hydrolyzing) activity
TTMY_2043	COG1854	S-ribosylhomocysteine lyase activity
TTMY_2044	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
TTMY_2045	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
TTMY_2046	COG0322	excinuclease ABC activity
TTMY_2047	COG0322	excinuclease ABC activity
TTMY_2049	COG2050	protein possibly involved in aromatic compounds catabolism
TTMY_2054	COG0037	tRNA processing
TTMY_2054	COG0590	tRNA wobble adenosine to inosine editing
TTMY_2057	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
TTMY_2058	COG0538	isocitrate dehydrogenase activity
TTMY_2059	COG0557	exoribonuclease II activity
TTMY_2062	COG0585	pseudouridine synthase activity
TTMY_2066	COG0604	alcohol dehydrogenase
TTMY_2069	COG0497	DNA recombination
TTMY_2070	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
TTMY_2071	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
TTMY_2075	COG0116	Belongs to the methyltransferase superfamily
TTMY_2076	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
TTMY_2077	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
TTMY_2078	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
TTMY_2080	COG0047	phosphoribosylformylglycinamidine synthase activity
TTMY_2082	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
TTMY_2085	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
TTMY_2092	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
TTMY_2095	COG5002	protein histidine kinase activity
TTMY_2095	COG3850	Histidine kinase
TTMY_2097	COG1272	protein, Hemolysin III
TTMY_2098	COG0574	Belongs to the PEP-utilizing enzyme family
TTMY_2098	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
TTMY_2099	COG0714	Associated with various cellular activities
TTMY_2102	COG1310	metal-dependent protease of the Pad1 Jab1 superfamily
TTMY_2104	COG1714	RDD family
TTMY_2105	COG0616	signal peptide processing
TTMY_2106	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
TTMY_2107	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
TTMY_2108	COG0443	Heat shock 70 kDa protein
TTMY_2109	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
TTMY_2110	COG0484	heat shock protein binding
TTMY_2111	COG0789	Transcriptional regulator
TTMY_2112	COG0542	response to heat
TTMY_2117	COG3118	belongs to the thioredoxin family
TTMY_2121	COG0490	domain, Protein
TTMY_2122	COG0475	glutathione-regulated potassium exporter activity
TTMY_2125	COG1227	inorganic diphosphatase activity
TTMY_2125	COG0517	IMP dehydrogenase activity
TTMY_2126	COG0475	glutathione-regulated potassium exporter activity
TTMY_2128	COG0305	Participates in initiation and elongation during chromosome replication
TTMY_2129	COG0840	transmembrane signaling receptor activity
TTMY_2137	COG0070	glutamate synthase
TTMY_2137	COG0067	glutamate synthase
TTMY_2137	COG0069	glutamate synthase activity
TTMY_2138	COG0069	glutamate synthase activity
TTMY_2138	COG0070	glutamate synthase
TTMY_2138	COG0067	glutamate synthase
TTMY_2142	COG0504	CTP synthase activity
TTMY_2143	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
TTMY_2144	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
TTMY_2145	COG0318	PFAM AMP-dependent synthetase and ligase
TTMY_2146	COG0318	PFAM AMP-dependent synthetase and ligase
TTMY_2152	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
TTMY_2153	COG2009	succinate dehydrogenase
TTMY_2156	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
TTMY_2157	COG0017	Asparaginyl-tRNA synthetase
TTMY_2160	COG0084	hydrolase, TatD family'
TTMY_2161	COG0427	acetyl-CoA hydrolase
TTMY_2162	COG0686	Belongs to the AlaDH PNT family
TTMY_2163	COG1494	fructose-1,6-bisphosphatase
TTMY_2164	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
TTMY_2164	COG0140	phosphoribosyl-ATP diphosphatase activity
TTMY_2165	COG0107	imidazoleglycerol-phosphate synthase activity
TTMY_2167	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
TTMY_2169	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
TTMY_2172	COG2045	Belongs to the ComB family
TTMY_2173	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
TTMY_2174	COG1136	(ABC) transporter
TTMY_2176	COG1024	Enoyl-CoA hydratase
TTMY_2179	COG3360	Dodecin
TTMY_2180	COG0318	PFAM AMP-dependent synthetase and ligase
TTMY_2186	COG3842	ATPase activity
TTMY_2187	COG2010	Cytochrome c
TTMY_2191	COG3258	Cytochrome c
TTMY_2192	COG2010	Cytochrome c
TTMY_2194	COG2010	Cytochrome c
TTMY_2195	COG3258	Cytochrome c
TTMY_2201	COG3258	Cytochrome c
TTMY_2202	COG0785	Cytochrome C biogenesis protein
TTMY_2203	COG4133	protoheme IX ABC transporter activity
TTMY_2204	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
TTMY_2206	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
TTMY_2207	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
TTMY_2208	COG1138	Cytochrome C-type biogenesis protein
TTMY_2209	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
TTMY_2210	COG4235	cytochrome complex assembly
TTMY_2210	COG3088	subunit of a heme lyase
TTMY_2215	COG5343	regulation of RNA biosynthetic process
TTMY_2224	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
TTMY_2225	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
TTMY_2228	COG0083	homoserine kinase activity
TTMY_2230	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
TTMY_2230	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
TTMY_2231	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
TTMY_2231	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
TTMY_2232	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
TTMY_2233	COG1160	GTP binding
TTMY_2235	COG0736	holo-[acyl-carrier-protein] synthase activity
TTMY_2236	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
TTMY_2236	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
TTMY_2237	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
TTMY_2238	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
TTMY_2239	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
TTMY_2240	COG1450	Type ii and iii secretion system protein
TTMY_2246	COG0473	3-isopropylmalate dehydrogenase activity
TTMY_2254	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
TTMY_2256	COG0860	N-Acetylmuramoyl-L-alanine amidase
TTMY_2258	COG0515	serine threonine protein kinase
TTMY_2258	COG2815	serine threonine protein kinase
TTMY_2259	COG1752	Esterase of the alpha-beta hydrolase superfamily
TTMY_2262	COG1556	Lactate utilization protein
TTMY_2263	COG1139	Iron-sulfur cluster binding protein
TTMY_2265	COG0247	lactate metabolic process
TTMY_2267	COG5002	protein histidine kinase activity
TTMY_2267	COG3850	Histidine kinase
TTMY_2271	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
TTMY_2274	COG1324	tolerance protein
TTMY_2275	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
TTMY_2276	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
TTMY_2277	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
TTMY_2279	COG0739	heme binding
TTMY_2280	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
TTMY_2282	COG2197	response regulator
TTMY_2285	COG0776	regulation of translation
TTMY_2287	COG1515	deoxyribonuclease V activity
TTMY_2289	COG1482	cell wall glycoprotein biosynthetic process
TTMY_2290	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
TTMY_2291	COG0372	Belongs to the citrate synthase family
TTMY_2292	COG1132	(ABC) transporter
TTMY_2293	COG1132	(ABC) transporter
TTMY_2294	COG0285	dihydrofolate synthase activity
TTMY_2300	COG0559	Belongs to the binding-protein-dependent transport system permease family
TTMY_2303	COG0174	glutamine synthetase
TTMY_2304	COG0737	Belongs to the 5'-nucleotidase family
TTMY_2306	COG2010	Cytochrome c
TTMY_2309	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
TTMY_2310	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
TTMY_2311	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
TTMY_2312	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
TTMY_2313	COG0788	formyltetrahydrofolate deformylase activity
TTMY_2314	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
TTMY_2321	COG1994	Peptidase M50
TTMY_2321	COG0517	IMP dehydrogenase activity
TTMY_2323	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
TTMY_2324	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
TTMY_2330	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
TTMY_2334	COG0746	molybdenum cofactor guanylyltransferase activity
TTMY_2335	COG1129	ABC transporter
TTMY_2336	COG1129	ABC transporter
TTMY_2340	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
TTMY_2341	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
TTMY_2342	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
TTMY_2342	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
TTMY_2344	COG0793	Belongs to the peptidase S41A family
TTMY_2345	COG2884	Cell division ATP-binding protein ftsE
TTMY_2346	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
TTMY_2350	COG0420	3'-5' exonuclease activity
TTMY_2351	COG0419	ATPase involved in DNA repair
TTMY_2356	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
TTMY_2358	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
TTMY_2363	COG1269	ATP hydrolysis coupled proton transport
TTMY_2365	COG1390	Produces ATP from ADP in the presence of a proton gradient across the membrane
TTMY_2366	COG1527	subunit (C
TTMY_2367	COG1436	Produces ATP from ADP in the presence of a proton gradient across the membrane
TTMY_2368	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
TTMY_2369	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
TTMY_2370	COG1156	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit
TTMY_2371	COG1394	ATPase activity, coupled to movement of substances
TTMY_2374	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
TTMY_2376	COG0612	Peptidase, M16
TTMY_2377	COG0612	Peptidase, M16
TTMY_2378	COG0697	spore germination
TTMY_2379	COG0697	spore germination
TTMY_2380	COG1250	3-hydroxyacyl-CoA dehydrogenase
TTMY_2383	COG0358	DNA primase activity
TTMY_2386	COG1205	dead DEAH box helicase
TTMY_2386	COG1111	helicase
TTMY_2387	COG0393	Putative heavy-metal-binding
TTMY_2391	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
TTMY_2392	COG0653	protein targeting
TTMY_2393	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
TTMY_2394	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
TTMY_2397	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
TTMY_2398	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
TTMY_2400	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
TTMY_2400	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
TTMY_2405	COG1733	regulation of RNA biosynthetic process
TTMY_2406	COG2894	cell division
TTMY_2407	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
TTMY_2408	COG0772	Belongs to the SEDS family
TTMY_2409	COG0772	Belongs to the SEDS family
TTMY_2410	COG3842	ATPase activity
TTMY_2412	COG1177	transmembrane transport
TTMY_2413	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
TTMY_2416	COG0129	dihydroxy-acid dehydratase activity
TTMY_2417	COG1028	Short-chain dehydrogenase reductase Sdr
TTMY_2420	COG0473	3-isopropylmalate dehydrogenase activity
TTMY_2421	COG0066	3-isopropylmalate dehydratase activity
TTMY_2422	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
TTMY_2423	COG0544	peptidyl-prolyl cis-trans isomerase activity
TTMY_2424	COG0180	Tryptophanyl-tRNA synthetase
TTMY_2427	COG4636	protein conserved in cyanobacteria
TTMY_2437	COG0492	ferredoxin-NADP+ reductase activity
TTMY_2438	COG0028	Belongs to the TPP enzyme family
TTMY_2439	COG0440	acetolactate synthase activity
TTMY_2440	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
TTMY_2442	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
TTMY_2445	COG1131	(ABC) transporter
TTMY_2452	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
TTMY_2455	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
TTMY_2457	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
TTMY_2458	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
TTMY_2466	COG0768	penicillin binding
TTMY_2467	COG0768	penicillin binding
TTMY_2471	COG0424	maF-like protein
TTMY_2473	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
TTMY_2474	COG0012	GTP binding
TTMY_2477	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
TTMY_2478	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
TTMY_2479	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
TTMY_2482	COG2313	pseudouridylate synthase activity
TTMY_2483	COG1426	Protein conserved in bacteria
TTMY_2484	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
TTMY_2485	COG0569	domain protein
TTMY_2486	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
TTMY_2488	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
TTMY_2489	COG0765	amino acid transport
TTMY_2490	COG0525	valine-tRNA ligase activity
TTMY_2495	COG4607	ABC-type enterochelin transport system periplasmic component
TTMY_2496	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
TTMY_2497	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
TTMY_2498	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
TTMY_2500	COG2329	Antibiotic biosynthesis monooxygenase
TTMY_2501	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
TTMY_2503	COG1607	acyl-coa hydrolase
TTMY_2513	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
TTMY_2528	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
TTMY_2531	COG1337	RAMP superfamily
TTMY_2535	COG2391	methyltransferase activity
TTMY_2537	COG2226	methyltransferase
TTMY_2539	COG1233	COG1233 Phytoene dehydrogenase and related
TTMY_2540	COG0702	epimerase
TTMY_2546	COG2414	aldehyde ferredoxin oxidoreductase
TTMY_2557	COG2205	protein histidine kinase activity
TTMY_2558	COG0745	RESPONSE REGULATOR receiver
TTMY_2559	COG0745	RESPONSE REGULATOR receiver
TTMY_2574	COG1192	Involved in chromosome partitioning
TTMY_2579	COG4974	Belongs to the 'phage' integrase family