locus-tag	class	description
TVNIR_0001	COG1132	(ABC) transporter
TVNIR_0002	COG0438	transferase activity, transferring glycosyl groups
TVNIR_0020	COG1484	DNA-dependent DNA replication
TVNIR_0047	COG0463	Glycosyl transferase, family 2
TVNIR_0050	COG4969	Belongs to the N-Me-Phe pilin family
TVNIR_0052	COG4636	protein conserved in cyanobacteria
TVNIR_0055	COG2111	Na H antiporter
TVNIR_0055	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
TVNIR_0061	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
TVNIR_0062	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
TVNIR_0062	COG0662	Cupin 2, conserved barrel domain protein
TVNIR_0067	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
TVNIR_0068	COG0140	phosphoribosyl-ATP diphosphatase activity
TVNIR_0069	COG0107	imidazoleglycerol-phosphate synthase activity
TVNIR_0070	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
TVNIR_0071	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
TVNIR_0072	COG0131	Imidazoleglycerol-phosphate dehydratase
TVNIR_0080	COG4106	trans-aconitate 2-methyltransferase activity
TVNIR_0081	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
TVNIR_0084	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
TVNIR_0085	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
TVNIR_0087	COG2226	methyltransferase
TVNIR_0089	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
TVNIR_0091	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
TVNIR_0091	COG2111	Na H antiporter
TVNIR_0092	COG0651	ATP synthesis coupled electron transport
TVNIR_0093	COG0651	ATP synthesis coupled electron transport
TVNIR_0094	COG1006	Multisubunit Na H antiporter MnhC subunit
TVNIR_0095	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
TVNIR_0095	COG2111	Na H antiporter
TVNIR_0097	COG1320	monovalent cation:proton antiporter activity
TVNIR_0101	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
TVNIR_0105	COG0267	Belongs to the bacterial ribosomal protein bL33 family
TVNIR_0106	COG0227	Belongs to the bacterial ribosomal protein bL28 family
TVNIR_0107	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
TVNIR_0111	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
TVNIR_0112	COG2197	response regulator
TVNIR_0122	COG3267	Type II secretory pathway component ExeA
TVNIR_0122	COG3409	Peptidoglycan-binding domain 1 protein
TVNIR_0128	COG3706	GGDEF domain
TVNIR_0131	COG2010	Cytochrome c
TVNIR_0133	COG1404	Belongs to the peptidase S8 family
TVNIR_0136	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
TVNIR_0137	COG1074	ATP-dependent DNA helicase activity
TVNIR_0138	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
TVNIR_0140	COG2226	methyltransferase
TVNIR_0143	COG0247	lactate metabolic process
TVNIR_0144	COG1139	Iron-sulfur cluster binding protein
TVNIR_0145	COG1620	l-lactate permease
TVNIR_0146	COG2226	methyltransferase
TVNIR_0148	COG1595	DNA-templated transcription, initiation
TVNIR_0152	COG1111	helicase
TVNIR_0152	COG1205	dead DEAH box helicase
TVNIR_0159	COG0142	geranyltranstransferase activity
TVNIR_0160	COG0261	This protein binds to 23S rRNA in the presence of protein L20
TVNIR_0161	COG0211	Belongs to the bacterial ribosomal protein bL27 family
TVNIR_0162	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
TVNIR_0163	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
TVNIR_0164	COG0268	Binds directly to 16S ribosomal RNA
TVNIR_0167	COG0196	riboflavin kinase activity
TVNIR_0168	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
TVNIR_0169	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
TVNIR_0170	COG1047	Peptidyl-prolyl cis-trans
TVNIR_0171	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
TVNIR_0183	COG0606	chelatase, subunit chli
TVNIR_0185	COG1028	Short-chain dehydrogenase reductase Sdr
TVNIR_0188	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
TVNIR_0189	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
TVNIR_0191	COG0596	Alpha beta hydrolase
TVNIR_0192	COG2226	methyltransferase
TVNIR_0193	COG3278	Belongs to the heme-copper respiratory oxidase family
TVNIR_0196	COG2010	Cytochrome c
TVNIR_0197	COG0348	domain, Protein
TVNIR_0199	COG2217	Heavy metal translocating P-type atpase
TVNIR_0207	COG2884	Cell division ATP-binding protein ftsE
TVNIR_0208	COG0552	protein localization to endoplasmic reticulum
TVNIR_0209	COG0612	Peptidase, M16
TVNIR_0210	COG0612	Peptidase, M16
TVNIR_0211	COG0742	ribosomal rna small subunit methyltransferase
TVNIR_0215	COG2197	response regulator
TVNIR_0220	COG0741	lytic transglycosylase activity
TVNIR_0221	COG1187	pseudouridine synthase activity
TVNIR_0224	COG0039	L-malate dehydrogenase activity
TVNIR_0225	COG0281	malic enzyme
TVNIR_0227	COG0254	rRNA binding
TVNIR_0228	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
TVNIR_0231	COG0058	SHG alpha-glucan phosphorylase activity
TVNIR_0232	COG0151	Belongs to the GarS family
TVNIR_0236	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
TVNIR_0237	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
TVNIR_0242	COG3153	acetyltransferase
TVNIR_0242	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
TVNIR_0251	COG0483	inositol monophosphate 1-phosphatase activity
TVNIR_0255	COG0488	(ABC) transporter
TVNIR_0256	COG0446	pyridine nucleotide-disulphide oxidoreductase
TVNIR_0259	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
TVNIR_0261	COG1138	Cytochrome C-type biogenesis protein
TVNIR_0262	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
TVNIR_0263	COG3088	subunit of a heme lyase
TVNIR_0267	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
TVNIR_0269	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
TVNIR_0271	COG3850	Histidine kinase
TVNIR_0272	COG2197	response regulator
TVNIR_0275	COG2918	glutathione biosynthetic process
TVNIR_0276	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
TVNIR_0277	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
TVNIR_0278	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
TVNIR_0279	COG0438	transferase activity, transferring glycosyl groups
TVNIR_0289	COG0494	nUDIX hydrolase
TVNIR_0291	COG1011	Hydrolase
TVNIR_0303	COG0540	Belongs to the ATCase OTCase family
TVNIR_0306	COG1678	Uncharacterized ACR, COG1678
TVNIR_0307	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
TVNIR_0311	COG0189	ligase activity
TVNIR_0320	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
TVNIR_0324	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
TVNIR_0324	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
TVNIR_0332	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
TVNIR_0336	COG1385	rRNA (uridine-N3-)-methyltransferase activity
TVNIR_0337	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
TVNIR_0338	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
TVNIR_0339	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
TVNIR_0340	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
TVNIR_0341	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
TVNIR_0342	COG0126	phosphoglycerate kinase activity
TVNIR_0343	COG0469	pyruvate kinase activity
TVNIR_0344	COG0191	fructose-bisphosphate aldolase activity
TVNIR_0346	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
TVNIR_0347	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
TVNIR_0348	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
TVNIR_0349	COG2813	Specifically methylates the guanine in position
TVNIR_0353	COG0546	phosphoglycolate phosphatase activity
TVNIR_0359	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
TVNIR_0360	COG0134	indole-3-glycerol-phosphate synthase activity
TVNIR_0362	COG1765	OsmC-like protein
TVNIR_0363	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
TVNIR_0364	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
TVNIR_0372	COG1595	DNA-templated transcription, initiation
TVNIR_0375	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
TVNIR_0376	COG3178	'Phosphotransferase
TVNIR_0377	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
TVNIR_0378	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
TVNIR_0379	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
TVNIR_0380	COG1166	arginine decarboxylase activity
TVNIR_0381	COG3100	YcgL domain-containing protein
TVNIR_0390	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
TVNIR_0394	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
TVNIR_0395	COG2003	Belongs to the UPF0758 family
TVNIR_0397	COG2210	Belongs to the sulfur carrier protein TusA family
TVNIR_0402	COG0156	8-amino-7-oxononanoate synthase activity
TVNIR_0403	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
TVNIR_0406	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
TVNIR_0407	COG2885	chlorophyll binding
TVNIR_0408	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
TVNIR_0410	COG0408	coproporphyrinogen oxidase activity
TVNIR_0412	COG0009	L-threonylcarbamoyladenylate synthase
TVNIR_0414	COG2922	Belongs to the Smg family
TVNIR_0415	COG0758	DNA mediated transformation
TVNIR_0417	COG0242	peptide deformylase activity
TVNIR_0418	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
TVNIR_0419	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
TVNIR_0421	COG5000	phosphorelay sensor kinase activity
TVNIR_0422	COG2204	response regulator
TVNIR_0423	COG0569	domain protein
TVNIR_0428	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
TVNIR_0429	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
TVNIR_0431	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
TVNIR_0433	COG0517	IMP dehydrogenase activity
TVNIR_0433	COG0516	GMP reductase activity
TVNIR_0436	COG0004	ammonium transporteR
TVNIR_0437	COG0577	efflux transmembrane transporter activity
TVNIR_0437	COG1136	(ABC) transporter
TVNIR_0438	COG0390	transport system, permease component
TVNIR_0447	COG1309	transcriptional regulator
TVNIR_0449	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
TVNIR_0449	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
TVNIR_0452	COG0189	ligase activity
TVNIR_0452	COG0569	domain protein
TVNIR_0454	COG0583	DNA-binding transcription factor activity
TVNIR_0455	COG3264	Mechanosensitive ion channel
TVNIR_0455	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
TVNIR_0459	COG0129	dihydroxy-acid dehydratase activity
TVNIR_0463	COG3263	regulation of cellular component size
TVNIR_0472	COG2264	protein methyltransferase activity
TVNIR_0473	COG0439	Biotin carboxylase
TVNIR_0474	COG0511	ligase activity, forming carbon-carbon bonds
TVNIR_0476	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
TVNIR_0477	COG4232	protein-disulfide reductase activity
TVNIR_0478	COG1324	tolerance protein
TVNIR_0482	COG3030	protein affecting phage T7 exclusion by the F plasmid
TVNIR_0483	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
TVNIR_0484	COG0459	protein refolding
TVNIR_0486	COG2885	chlorophyll binding
TVNIR_0486	COG3047	cAMP biosynthetic process
TVNIR_0491	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
TVNIR_0493	COG0577	efflux transmembrane transporter activity
TVNIR_0493	COG1136	(ABC) transporter
TVNIR_0496	COG2911	Protein conserved in bacteria
TVNIR_0497	COG0729	surface antigen
TVNIR_0499	COG3842	ATPase activity
TVNIR_0500	COG1178	ABC-type Fe3 transport system permease component
TVNIR_0501	COG1840	ABC-type Fe3 transport system, periplasmic component
TVNIR_0502	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
TVNIR_0505	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
TVNIR_0508	COG3706	GGDEF domain
TVNIR_0511	COG3744	PilT protein domain protein
TVNIR_0517	COG1396	sequence-specific DNA binding
TVNIR_0519	COG1487	ribonuclease activity
TVNIR_0538	COG3275	phosphorelay sensor kinase activity
TVNIR_0540	COG3706	GGDEF domain
TVNIR_0541	COG1262	PFAM Formylglycine-generating sulfatase enzyme
TVNIR_0542	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
TVNIR_0543	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
TVNIR_0551	COG0446	pyridine nucleotide-disulphide oxidoreductase
TVNIR_0556	COG0745	RESPONSE REGULATOR receiver
TVNIR_0557	COG2205	protein histidine kinase activity
TVNIR_0562	COG0189	ligase activity
TVNIR_0562	COG4067	protein conserved in archaea
TVNIR_0563	COG1560	Kdo2-lipid A biosynthetic process
TVNIR_0566	COG2226	methyltransferase
TVNIR_0567	COG1132	(ABC) transporter
TVNIR_0569	COG0659	secondary active sulfate transmembrane transporter activity
TVNIR_0571	COG2200	EAL domain
TVNIR_0575	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
TVNIR_0576	COG1028	Short-chain dehydrogenase reductase Sdr
TVNIR_0579	COG1671	Belongs to the UPF0178 family
TVNIR_0584	COG1918	ferrous iron import across plasma membrane
TVNIR_0584	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
TVNIR_0593	COG1116	anion transmembrane transporter activity
TVNIR_0596	COG4771	TonB-dependent receptor
TVNIR_0597	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
TVNIR_0598	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
TVNIR_0599	COG4558	Periplasmic binding protein
TVNIR_0600	COG3720	iron ion transport
TVNIR_0602	COG4206	TonB-dependent receptor
TVNIR_0613	COG0067	glutamate synthase
TVNIR_0613	COG0070	glutamate synthase
TVNIR_0613	COG0069	glutamate synthase activity
TVNIR_0616	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
TVNIR_0623	COG3077	Addiction module antitoxin, RelB DinJ family
TVNIR_0625	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
TVNIR_0626	COG3077	Addiction module antitoxin, RelB DinJ family
TVNIR_0628	COG1598	PFAM Uncharacterised protein family UPF0150
TVNIR_0631	COG3609	addiction module antidote protein, CC2985 family
TVNIR_0634	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
TVNIR_0637	COG3077	Addiction module antitoxin, RelB DinJ family
TVNIR_0639	COG1848	Toxic component of a toxin-antitoxin (TA) module. An RNase
TVNIR_0641	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
TVNIR_0650	COG3657	addiction module killer protein
TVNIR_0653	COG1598	PFAM Uncharacterised protein family UPF0150
TVNIR_0659	COG3077	Addiction module antitoxin, RelB DinJ family
TVNIR_0671	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
TVNIR_0674	COG1598	PFAM Uncharacterised protein family UPF0150
TVNIR_0677	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
TVNIR_0680	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
TVNIR_0681	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
TVNIR_0686	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
TVNIR_0709	COG1434	Gram-negative-bacterium-type cell wall biogenesis
TVNIR_0711	COG1598	PFAM Uncharacterised protein family UPF0150
TVNIR_0728	COG2944	sequence-specific DNA binding
TVNIR_0732	COG1434	Gram-negative-bacterium-type cell wall biogenesis
TVNIR_0735	COG1434	Gram-negative-bacterium-type cell wall biogenesis
TVNIR_0742	COG1434	Gram-negative-bacterium-type cell wall biogenesis
TVNIR_0746	COG1434	Gram-negative-bacterium-type cell wall biogenesis
TVNIR_0763	COG1434	Gram-negative-bacterium-type cell wall biogenesis
TVNIR_0766	COG1598	PFAM Uncharacterised protein family UPF0150
TVNIR_0773	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
TVNIR_0774	COG1086	Polysaccharide biosynthesis protein
TVNIR_0776	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
TVNIR_0777	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
TVNIR_0783	COG3409	Peptidoglycan-binding domain 1 protein
TVNIR_0783	COG3267	Type II secretory pathway component ExeA
TVNIR_0789	COG3311	Transcriptional regulator
TVNIR_0790	COG1569	PIN domain
TVNIR_0796	COG3153	acetyltransferase
TVNIR_0804	COG2205	protein histidine kinase activity
TVNIR_0805	COG0745	RESPONSE REGULATOR receiver
TVNIR_0808	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
TVNIR_0808	COG0678	peroxiredoxin activity
TVNIR_0810	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
TVNIR_0811	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
TVNIR_0812	COG0537	adenosine 5'-monophosphoramidase activity
TVNIR_0817	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
TVNIR_0823	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
TVNIR_0825	COG0481	GTPase activity
TVNIR_0826	COG0681	Belongs to the peptidase S26 family
TVNIR_0828	COG0571	ribonuclease III activity
TVNIR_0829	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
TVNIR_0831	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
TVNIR_0832	COG0736	holo-[acyl-carrier-protein] synthase activity
TVNIR_0835	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
TVNIR_0836	COG0811	peptide transport
TVNIR_0837	COG0848	biopolymer transport protein
TVNIR_0838	COG1132	(ABC) transporter
TVNIR_0840	COG1663	tetraacyldisaccharide 4'-kinase activity
TVNIR_0841	COG2835	tetraacyldisaccharide 4'-kinase activity
TVNIR_0843	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
TVNIR_0846	COG3128	pkhd-type hydroxylase
TVNIR_0848	COG1797	cobyrinic acid a,c-diamide synthase activity
TVNIR_0855	COG2920	part of a sulfur-relay system
TVNIR_0857	COG2923	Belongs to the DsrF TusC family
TVNIR_0858	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
TVNIR_0859	COG2221	Nitrite and sulphite reductase 4Fe-4S
TVNIR_0860	COG2221	Nitrite and sulphite reductase 4Fe-4S
TVNIR_0865	COG2920	part of a sulfur-relay system
TVNIR_0872	COG0105	UTP biosynthetic process
TVNIR_0873	COG0820	rRNA (adenine-C2-)-methyltransferase activity
TVNIR_0876	COG0124	histidyl-tRNA synthetase
TVNIR_0879	COG1160	GTP binding
TVNIR_0882	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
TVNIR_0884	COG0215	cysteine-tRNA ligase activity
TVNIR_0885	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
TVNIR_0887	COG2988	succinylglutamate desuccinylase activity
TVNIR_0889	COG3706	GGDEF domain
TVNIR_0894	COG0545	Peptidyl-prolyl cis-trans isomerase
TVNIR_0898	COG0581	inorganic phosphate transmembrane transporter activity
TVNIR_0899	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
TVNIR_0900	COG0704	Plays a role in the regulation of phosphate uptake
TVNIR_0901	COG0737	Belongs to the 5'-nucleotidase family
TVNIR_0903	COG0058	SHG alpha-glucan phosphorylase activity
TVNIR_0907	COG1741	Belongs to the pirin family
TVNIR_0909	COG3093	addiction module antidote protein HigA
TVNIR_0911	COG4584	PFAM Integrase catalytic
TVNIR_0913	COG4974	Belongs to the 'phage' integrase family
TVNIR_0916	COG4974	Belongs to the 'phage' integrase family
TVNIR_0917	COG1484	DNA-dependent DNA replication
TVNIR_0923	COG1061	Type III restriction enzyme res subunit
TVNIR_0934	COG0709	Synthesizes selenophosphate from selenide and ATP
TVNIR_0935	COG3639	organic phosphonate transmembrane transporter activity
TVNIR_0936	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
TVNIR_0938	COG3276	selenocysteine insertion sequence binding
TVNIR_0943	COG1047	Peptidyl-prolyl cis-trans
TVNIR_0948	COG0437	4 iron, 4 sulfur cluster binding
TVNIR_0949	COG0243	molybdopterin cofactor binding
TVNIR_0951	COG4636	protein conserved in cyanobacteria
TVNIR_0953	COG4191	Histidine kinase
TVNIR_0955	COG2897	thiosulfate sulfurtransferase activity
TVNIR_0962	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
TVNIR_0971	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
TVNIR_0976	COG0437	4 iron, 4 sulfur cluster binding
TVNIR_0977	COG0243	molybdopterin cofactor binding
TVNIR_0979	COG2864	formate dehydrogenase
TVNIR_0980	COG0437	4 iron, 4 sulfur cluster binding
TVNIR_0981	COG0243	molybdopterin cofactor binding
TVNIR_0981	COG3383	formate dehydrogenase (NAD+) activity
TVNIR_0983	COG3383	formate dehydrogenase (NAD+) activity
TVNIR_0983	COG0243	molybdopterin cofactor binding
TVNIR_0990	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
TVNIR_0996	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
TVNIR_1005	COG0069	glutamate synthase activity
TVNIR_1013	COG1924	4 iron, 4 sulfur cluster binding
TVNIR_1020	COG3706	GGDEF domain
TVNIR_1020	COG0745	RESPONSE REGULATOR receiver
TVNIR_1021	COG1917	Cupin 2, conserved barrel domain protein
TVNIR_1021	COG4977	sequence-specific DNA binding
TVNIR_1024	COG2210	Belongs to the sulfur carrier protein TusA family
TVNIR_1028	COG3220	belongs to the UPF0276 family
TVNIR_1034	COG1960	acyl-CoA dehydrogenase activity
TVNIR_1036	COG1250	3-hydroxyacyl-CoA dehydrogenase
TVNIR_1036	COG1024	Enoyl-CoA hydratase
TVNIR_1037	COG1022	Amp-dependent synthetase and ligase
TVNIR_1039	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
TVNIR_1040	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
TVNIR_1043	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
TVNIR_1052	COG2205	protein histidine kinase activity
TVNIR_1056	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
TVNIR_1060	COG3079	Belongs to the UPF0149 family
TVNIR_1061	COG0006	proline dipeptidase activity
TVNIR_1062	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
TVNIR_1063	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
TVNIR_1064	COG0404	The glycine cleavage system catalyzes the degradation of glycine
TVNIR_1066	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
TVNIR_1068	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
TVNIR_1069	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
TVNIR_1072	COG1121	(ABC) transporter
TVNIR_1073	COG1108	ABC-type Mn2 Zn2 transport systems permease components
TVNIR_1076	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
TVNIR_1077	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
TVNIR_1078	COG1331	Highly conserved protein containing a thioredoxin domain
TVNIR_1091	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
TVNIR_1095	COG0318	PFAM AMP-dependent synthetase and ligase
TVNIR_1100	COG5002	protein histidine kinase activity
TVNIR_1106	COG2132	Multicopper oxidase
TVNIR_1110	COG0537	adenosine 5'-monophosphoramidase activity
TVNIR_1112	COG3387	PFAM Glycoside hydrolase 15-related
TVNIR_1119	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
TVNIR_1120	COG1140	nitrate reductase beta subunit
TVNIR_1147	COG0210	DNA helicase
TVNIR_1153	COG4636	protein conserved in cyanobacteria
TVNIR_1154	COG2161	toxin-antitoxin pair type II binding
TVNIR_1159	COG3273	potassium ion transport
TVNIR_1159	COG0471	metal ion transport
TVNIR_1160	COG1247	-acetyltransferase
TVNIR_1162	COG1216	Glycosyl transferase, family 2
TVNIR_1170	COG3012	SEC-C Motif Domain Protein
TVNIR_1170	COG3318	Belongs to the UPF0149 family
TVNIR_1171	COG0418	dihydroorotase activity
TVNIR_1175	COG0446	pyridine nucleotide-disulphide oxidoreductase
TVNIR_1178	COG0433	COG0433 Predicted ATPase
TVNIR_1190	COG1175	transmembrane transport
TVNIR_1191	COG0395	ABC-type sugar transport system, permease component
TVNIR_1192	COG3842	ATPase activity
TVNIR_1195	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
TVNIR_1199	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
TVNIR_1200	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
TVNIR_1202	COG1752	Esterase of the alpha-beta hydrolase superfamily
TVNIR_1203	COG0484	heat shock protein binding
TVNIR_1208	COG1522	sequence-specific DNA binding
TVNIR_1210	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
TVNIR_1211	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
TVNIR_1212	COG0066	3-isopropylmalate dehydratase activity
TVNIR_1213	COG0473	3-isopropylmalate dehydrogenase activity
TVNIR_1214	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
TVNIR_1219	COG0135	phosphoribosylanthranilate isomerase activity
TVNIR_1220	COG0133	tryptophan synthase activity
TVNIR_1221	COG0159	tryptophan synthase activity
TVNIR_1222	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
TVNIR_1223	COG0285	dihydrofolate synthase activity
TVNIR_1225	COG1286	toxin biosynthetic process
TVNIR_1227	COG1376	ErfK ybiS ycfS ynhG family protein
TVNIR_1228	COG1959	2 iron, 2 sulfur cluster binding
TVNIR_1231	COG0714	Associated with various cellular activities
TVNIR_1232	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
TVNIR_1233	COG1127	ABC transporter
TVNIR_1234	COG3008	intermembrane lipid transfer
TVNIR_1234	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
TVNIR_1236	COG0590	tRNA wobble adenosine to inosine editing
TVNIR_1237	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
TVNIR_1238	COG1028	Short-chain dehydrogenase reductase Sdr
TVNIR_1241	COG5394	Polyhydroxyalkanoate synthesis repressor PhaR
TVNIR_1242	COG0183	Belongs to the thiolase family
TVNIR_1245	COG3243	poly(R)-hydroxyalkanoic acid synthase
TVNIR_1246	COG0788	formyltetrahydrofolate deformylase activity
TVNIR_1249	COG3550	peptidyl-serine autophosphorylation
TVNIR_1253	COG0210	DNA helicase
TVNIR_1256	COG0430	RNA-3'-phosphate cyclase activity
TVNIR_1257	COG1234	tRNA 3'-trailer cleavage
TVNIR_1263	COG1053	succinate dehydrogenase
TVNIR_1264	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
TVNIR_1265	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
TVNIR_1268	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
TVNIR_1275	COG0121	glutamine amidotransferase
TVNIR_1276	COG2062	phosphohistidine phosphatase, SixA
TVNIR_1280	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
TVNIR_1281	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
TVNIR_1283	COG0471	metal ion transport
TVNIR_1289	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
TVNIR_1290	COG2943	transferase activity, transferring hexosyl groups
TVNIR_1291	COG3038	cytochrome b561
TVNIR_1293	COG0471	metal ion transport
TVNIR_1293	COG3273	potassium ion transport
TVNIR_1301	COG0501	Belongs to the peptidase M48B family
TVNIR_1309	COG2078	PFAM AMMECR1 domain protein
TVNIR_1309	COG3885	ferrous iron binding
TVNIR_1310	COG1355	regulation of microtubule-based process
TVNIR_1313	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
TVNIR_1313	COG1024	Enoyl-CoA hydratase
TVNIR_1319	COG0310	cobalt ion transport
TVNIR_1321	COG1122	ATPase activity
TVNIR_1322	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
TVNIR_1325	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
TVNIR_1326	COG2267	carboxylic ester hydrolase activity
TVNIR_1330	COG0437	4 iron, 4 sulfur cluster binding
TVNIR_1331	COG0348	domain, Protein
TVNIR_1333	COG2226	methyltransferase
TVNIR_1339	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
TVNIR_1343	COG0517	IMP dehydrogenase activity
TVNIR_1344	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
TVNIR_1351	COG2409	Drug exporters of the RND superfamily
TVNIR_1356	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
TVNIR_1357	COG4139	cobalamin transport
TVNIR_1358	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
TVNIR_1359	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
TVNIR_1362	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
TVNIR_1363	COG4566	intracellular signal transduction
TVNIR_1369	COG0424	maF-like protein
TVNIR_1370	COG5016	pyruvate
TVNIR_1370	COG0511	ligase activity, forming carbon-carbon bonds
TVNIR_1371	COG0439	Biotin carboxylase
TVNIR_1373	COG0333	Belongs to the bacterial ribosomal protein bL32 family
TVNIR_1374	COG0416	fatty acid biosynthetic process
TVNIR_1375	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
TVNIR_1377	COG1573	uracil-dna glycosylase
TVNIR_1378	COG0322	excinuclease ABC activity
TVNIR_1379	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
TVNIR_1380	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
TVNIR_1388	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
TVNIR_1390	COG0372	Belongs to the citrate synthase family
TVNIR_1391	COG1335	isochorismatase
TVNIR_1408	COG0850	regulation of cytokinetic process
TVNIR_1409	COG2894	cell division
TVNIR_1410	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
TVNIR_1411	COG2738	Putative neutral zinc metallopeptidase
TVNIR_1412	COG0668	transmembrane transport
TVNIR_1415	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
TVNIR_1417	COG1070	Carbohydrate kinase
TVNIR_1418	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
TVNIR_1419	COG1196	nuclear chromosome segregation
TVNIR_1420	COG3115	cell septum assembly
TVNIR_1421	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
TVNIR_1422	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
TVNIR_1423	COG2350	Protein conserved in bacteria
TVNIR_1424	COG0009	L-threonylcarbamoyladenylate synthase
TVNIR_1425	COG1994	Peptidase M50
TVNIR_1428	COG0180	Tryptophanyl-tRNA synthetase
TVNIR_1430	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
TVNIR_1432	COG0521	Mo-molybdopterin cofactor biosynthetic process
TVNIR_1437	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
TVNIR_1440	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
TVNIR_1444	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
TVNIR_1445	COG1053	succinate dehydrogenase
TVNIR_1448	COG0033	Phosphoglucomutase
TVNIR_1450	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
TVNIR_1451	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
TVNIR_1452	COG1546	Belongs to the CinA family
TVNIR_1452	COG1058	Belongs to the CinA family
TVNIR_1453	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
TVNIR_1454	COG2137	regulation of response to DNA damage stimulus
TVNIR_1455	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
TVNIR_1457	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
TVNIR_1458	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
TVNIR_1461	COG1337	RAMP superfamily
TVNIR_1485	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
TVNIR_1486	COG1518	maintenance of DNA repeat elements
TVNIR_1488	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
TVNIR_1499	COG3300	MHYT domain
TVNIR_1499	COG5001	Diguanylate cyclase
TVNIR_1502	COG0071	Belongs to the small heat shock protein (HSP20) family
TVNIR_1505	COG0488	(ABC) transporter
TVNIR_1510	COG0167	dihydroorotate dehydrogenase activity
TVNIR_1515	COG1028	Short-chain dehydrogenase reductase Sdr
TVNIR_1516	COG4191	Histidine kinase
TVNIR_1517	COG4566	intracellular signal transduction
TVNIR_1518	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
TVNIR_1519	COG1562	ergosterol biosynthetic process
TVNIR_1521	COG1322	Protein conserved in bacteria
TVNIR_1523	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
TVNIR_1524	COG0402	S-adenosylhomocysteine deaminase activity
TVNIR_1527	COG1278	Cold shock
TVNIR_1528	COG0259	pyridoxamine-phosphate oxidase activity
TVNIR_1529	COG0069	glutamate synthase activity
TVNIR_1529	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
TVNIR_1531	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
TVNIR_1531	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
TVNIR_1532	COG0739	heme binding
TVNIR_1533	COG0842	Transport permease protein
TVNIR_1534	COG1131	(ABC) transporter
TVNIR_1535	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
TVNIR_1536	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
TVNIR_1542	COG2863	cytochrome
TVNIR_1543	COG0446	pyridine nucleotide-disulphide oxidoreductase
TVNIR_1545	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
TVNIR_1546	COG0745	RESPONSE REGULATOR receiver
TVNIR_1546	COG3706	GGDEF domain
TVNIR_1549	COG0067	glutamate synthase
TVNIR_1549	COG0070	glutamate synthase
TVNIR_1549	COG0069	glutamate synthase activity
TVNIR_1554	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
TVNIR_1559	COG2863	cytochrome
TVNIR_1568	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
TVNIR_1569	COG2850	peptidyl-arginine hydroxylation
TVNIR_1572	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
TVNIR_1573	COG2915	High frequency lysogenization protein hflD homolog
TVNIR_1574	COG0482	sulfurtransferase activity
TVNIR_1577	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
TVNIR_1578	COG0542	response to heat
TVNIR_1579	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
TVNIR_1581	COG1028	Short-chain dehydrogenase reductase Sdr
TVNIR_1582	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
TVNIR_1583	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
TVNIR_1584	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
TVNIR_1585	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
TVNIR_1586	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
TVNIR_1587	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
TVNIR_1591	COG1509	lysine 2,3-aminomutase activity
TVNIR_1608	COG1472	Belongs to the glycosyl hydrolase 3 family
TVNIR_1612	COG1335	isochorismatase
TVNIR_1618	COG3548	integral membrane protein
TVNIR_1622	COG1136	(ABC) transporter
TVNIR_1622	COG0577	efflux transmembrane transporter activity
TVNIR_1623	COG1136	(ABC) transporter
TVNIR_1630	COG4953	penicillin-binding protein 1C
TVNIR_1631	COG2373	Large extracellular alpha-helical protein
TVNIR_1634	COG0348	domain, Protein
TVNIR_1634	COG3901	Regulator of nitric oxide reductase transcription
TVNIR_1637	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
TVNIR_1648	COG0535	radical SAM domain protein
TVNIR_1651	COG4974	Belongs to the 'phage' integrase family
TVNIR_1652	COG0517	IMP dehydrogenase activity
TVNIR_1657	COG0714	Associated with various cellular activities
TVNIR_1661	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
TVNIR_1665	COG0318	PFAM AMP-dependent synthetase and ligase
TVNIR_1666	COG2050	protein possibly involved in aromatic compounds catabolism
TVNIR_1667	COG1752	Esterase of the alpha-beta hydrolase superfamily
TVNIR_1676	COG1104	cysteine desulfurase activity
TVNIR_1679	COG0602	queuosine metabolic process
TVNIR_1681	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
TVNIR_1691	COG1715	Restriction endonuclease
TVNIR_1692	COG0517	IMP dehydrogenase activity
TVNIR_1693	COG4974	Belongs to the 'phage' integrase family
TVNIR_1705	COG0446	pyridine nucleotide-disulphide oxidoreductase
TVNIR_1709	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
TVNIR_1711	COG0398	Pfam SNARE associated Golgi protein
TVNIR_1714	COG0714	Associated with various cellular activities
TVNIR_1715	COG1529	Aldehyde oxidase and xanthine dehydrogenase
TVNIR_1716	COG2080	2 iron, 2 sulfur cluster binding
TVNIR_1723	COG4636	protein conserved in cyanobacteria
TVNIR_1727	COG4636	protein conserved in cyanobacteria
TVNIR_1739	COG3179	chitinase
TVNIR_1748	COG2920	part of a sulfur-relay system
TVNIR_1749	COG2181	nitrate reductase activity
TVNIR_1750	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
TVNIR_1751	COG1140	nitrate reductase beta subunit
TVNIR_1752	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
TVNIR_1753	COG2223	nitrite transmembrane transporter activity
TVNIR_1756	COG3850	Histidine kinase
TVNIR_1757	COG2197	response regulator
TVNIR_1758	COG2920	part of a sulfur-relay system
TVNIR_1761	COG0516	GMP reductase activity
TVNIR_1761	COG0517	IMP dehydrogenase activity
TVNIR_1766	COG2221	Nitrite and sulphite reductase 4Fe-4S
TVNIR_1767	COG2221	Nitrite and sulphite reductase 4Fe-4S
TVNIR_1780	COG0523	cobalamin synthesis protein
TVNIR_1787	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
TVNIR_1789	COG2974	May be involved in recombination
TVNIR_1801	COG1210	Utp--glucose-1-phosphate uridylyltransferase
TVNIR_1802	COG1555	photosystem II stabilization
TVNIR_1802	COG1596	polysaccharide export
TVNIR_1803	COG0284	orotidine-5'-phosphate decarboxylase activity
TVNIR_1804	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
TVNIR_1805	COG0776	regulation of translation
TVNIR_1807	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
TVNIR_1808	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
TVNIR_1809	COG0287	Prephenate dehydrogenase
TVNIR_1813	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
TVNIR_1815	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
TVNIR_1816	COG0658	competence protein
TVNIR_1816	COG2333	competence protein COMEC
TVNIR_1818	COG1136	(ABC) transporter
TVNIR_1819	COG4591	ABC-type transport system involved in lipoprotein release permease component
TVNIR_1821	COG2957	Belongs to the agmatine deiminase family
TVNIR_1822	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
TVNIR_1824	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
TVNIR_1830	COG1530	ribonuclease E activity
TVNIR_1831	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
TVNIR_1832	COG0047	phosphoribosylformylglycinamidine synthase activity
TVNIR_1832	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
TVNIR_1835	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
TVNIR_1836	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
TVNIR_1837	COG0316	Belongs to the HesB IscA family
TVNIR_1839	COG2151	metal-sulfur cluster biosynthetic enzyme
TVNIR_1840	COG0719	Fe-S assembly protein
TVNIR_1841	COG0396	ATPase activity
TVNIR_1842	COG2166	iron-sulfur cluster assembly
TVNIR_1843	COG0719	Fe-S assembly protein
TVNIR_1844	COG1959	2 iron, 2 sulfur cluster binding
TVNIR_1845	COG2105	PFAM AIG2 family protein
TVNIR_1846	COG2171	N-acyltransferase activity
TVNIR_1847	COG1393	Belongs to the ArsC family
TVNIR_1849	COG2084	Dehydrogenase
TVNIR_1850	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
TVNIR_1853	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
TVNIR_1857	COG1196	nuclear chromosome segregation
TVNIR_1873	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
TVNIR_1874	COG0569	domain protein
TVNIR_1878	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
TVNIR_1880	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
TVNIR_1883	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
TVNIR_1885	COG0095	Lipoate-protein ligase
TVNIR_1886	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
TVNIR_1887	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
TVNIR_1888	COG0148	phosphopyruvate hydratase activity
TVNIR_1889	COG2877	3-deoxy-8-phosphooctulonate synthase activity
TVNIR_1890	COG0504	CTP synthase activity
TVNIR_1892	COG0825	malonyl-CoA metabolic process
TVNIR_1894	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
TVNIR_1895	COG0673	inositol 2-dehydrogenase activity
TVNIR_1897	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
TVNIR_1900	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
TVNIR_1913	COG1216	Glycosyl transferase, family 2
TVNIR_1914	COG1450	Type ii and iii secretion system protein
TVNIR_1919	COG4795	General secretion pathway protein
TVNIR_1923	COG1459	type II secretion system
TVNIR_1924	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
TVNIR_1925	COG0438	transferase activity, transferring glycosyl groups
TVNIR_1927	COG1088	dTDP-glucose 4,6-dehydratase activity
TVNIR_1933	COG4717	serine-type aminopeptidase activity
TVNIR_1934	COG0420	3'-5' exonuclease activity
TVNIR_1938	COG1388	LysM domain
TVNIR_1938	COG0741	lytic transglycosylase activity
TVNIR_1939	COG2989	Protein conserved in bacteria
TVNIR_1943	COG1007	ATP synthesis coupled electron transport
TVNIR_1945	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
TVNIR_1946	COG0713	ATP synthesis coupled electron transport
TVNIR_1948	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
TVNIR_1950	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
TVNIR_1951	COG1034	ATP synthesis coupled electron transport
TVNIR_1954	COG0649	NAD binding
TVNIR_1956	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
TVNIR_1957	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
TVNIR_1958	COG0058	SHG alpha-glucan phosphorylase activity
TVNIR_1960	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
TVNIR_1961	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
TVNIR_1966	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
TVNIR_1967	COG0575	Belongs to the CDS family
TVNIR_1968	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
TVNIR_1969	COG0233	cytoplasmic translational termination
TVNIR_1970	COG0528	UMP kinase activity
TVNIR_1971	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
TVNIR_1972	COG0052	Belongs to the universal ribosomal protein uS2 family
TVNIR_1973	COG0024	Methionine aminopeptidase
TVNIR_1974	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
TVNIR_1976	COG1643	Atp-dependent helicase
TVNIR_1986	COG4181	ATPase activity
TVNIR_1988	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
TVNIR_1995	COG2133	pyrroloquinoline quinone binding
TVNIR_2003	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
TVNIR_2011	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
TVNIR_2012	COG0674	pyruvate-flavodoxin oxidoreductase activity
TVNIR_2013	COG1013	pyruvate-flavodoxin oxidoreductase activity
TVNIR_2015	COG0306	phosphate transporter
TVNIR_2021	COG4133	protoheme IX ABC transporter activity
TVNIR_2025	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
TVNIR_2034	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
TVNIR_2038	COG0409	Hydrogenase expression formation protein
TVNIR_2043	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
TVNIR_2048	COG0375	protein maturation
TVNIR_2049	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
TVNIR_2050	COG1773	rubredoxin
TVNIR_2052	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
TVNIR_2061	COG1575	Belongs to the MenA family. Type 1 subfamily
TVNIR_2062	COG0702	epimerase
TVNIR_2067	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
TVNIR_2070	COG0741	lytic transglycosylase activity
TVNIR_2080	COG3300	MHYT domain
TVNIR_2080	COG5001	Diguanylate cyclase
TVNIR_2089	COG3657	addiction module killer protein
TVNIR_2090	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
TVNIR_2107	COG0582	viral genome integration into host DNA
TVNIR_2110	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
TVNIR_2112	COG0742	ribosomal rna small subunit methyltransferase
TVNIR_2119	COG1666	GTP binding
TVNIR_2120	COG2363	Small membrane protein
TVNIR_2122	COG0116	Belongs to the methyltransferase superfamily
TVNIR_2122	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
TVNIR_2124	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
TVNIR_2130	COG1222	aaa ATPase
TVNIR_2157	COG1376	ErfK ybiS ycfS ynhG family protein
TVNIR_2161	COG0438	transferase activity, transferring glycosyl groups
TVNIR_2162	COG0438	transferase activity, transferring glycosyl groups
TVNIR_2163	COG0463	Glycosyl transferase, family 2
TVNIR_2166	COG0859	PFAM glycosyl transferase family 9
TVNIR_2171	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
TVNIR_2173	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
TVNIR_2177	COG3278	Belongs to the heme-copper respiratory oxidase family
TVNIR_2180	COG2010	Cytochrome c
TVNIR_2184	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
TVNIR_2187	COG4797	methyltransferase
TVNIR_2187	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
TVNIR_2188	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
TVNIR_2190	COG1295	ribonuclease BN
TVNIR_2193	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
TVNIR_2196	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
TVNIR_2197	COG0321	lipoyl(octanoyl) transferase activity
TVNIR_2198	COG2921	Belongs to the UPF0250 family
TVNIR_2199	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
TVNIR_2200	COG1686	Belongs to the peptidase S11 family
TVNIR_2202	COG2951	lytic endotransglycosylase activity
TVNIR_2203	COG0772	Belongs to the SEDS family
TVNIR_2204	COG0768	penicillin binding
TVNIR_2205	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
TVNIR_2206	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
TVNIR_2207	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
TVNIR_2208	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
TVNIR_2209	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
TVNIR_2210	COG0837	glucose binding
TVNIR_2211	COG2967	ApaG domain
TVNIR_2212	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
TVNIR_2214	COG0776	regulation of translation
TVNIR_2215	COG0072	phenylalanine-tRNA ligase activity
TVNIR_2215	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
TVNIR_2216	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
TVNIR_2217	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
TVNIR_2218	COG0291	Belongs to the bacterial ribosomal protein bL35 family
TVNIR_2220	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
TVNIR_2221	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
TVNIR_2227	COG1968	undecaprenyl-diphosphatase activity
TVNIR_2228	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
TVNIR_2237	COG0277	FAD linked oxidase domain protein
TVNIR_2238	COG0277	FAD linked oxidase domain protein
TVNIR_2239	COG0247	lactate metabolic process
TVNIR_2240	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
TVNIR_2242	COG0039	L-malate dehydrogenase activity
TVNIR_2243	COG1262	PFAM Formylglycine-generating sulfatase enzyme
TVNIR_2247	COG2224	Isocitrate lyase
TVNIR_2248	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
TVNIR_2249	COG0247	lactate metabolic process
TVNIR_2251	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
TVNIR_2252	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
TVNIR_2253	COG1862	Preprotein translocase
TVNIR_2254	COG0343	queuine tRNA-ribosyltransferase activity
TVNIR_2255	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
TVNIR_2258	COG1205	dead DEAH box helicase
TVNIR_2258	COG1111	helicase
TVNIR_2260	COG3177	Filamentation induced by cAMP protein fic
TVNIR_2275	COG1943	Transposase
TVNIR_2276	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
TVNIR_2278	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
TVNIR_2307	COG1028	Short-chain dehydrogenase reductase Sdr
TVNIR_2308	COG3384	dioxygenase
TVNIR_2313	COG0702	epimerase
TVNIR_2323	COG3344	reverse transcriptase
TVNIR_2333	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
TVNIR_2334	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
TVNIR_2334	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
TVNIR_2340	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
TVNIR_2340	COG1017	nitric oxide dioxygenase activity
TVNIR_2341	COG3956	TIGRFAM MazG family protein
TVNIR_2343	COG1115	amino acid carrier protein
TVNIR_2359	COG0444	Belongs to the ABC transporter superfamily
TVNIR_2360	COG4608	Belongs to the ABC transporter superfamily
TVNIR_2363	COG1320	monovalent cation:proton antiporter activity
TVNIR_2364	COG2212	antiporter activity
TVNIR_2368	COG2111	Na H antiporter
TVNIR_2370	COG4991	sh3 domain protein
TVNIR_2372	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
TVNIR_2373	COG0717	Belongs to the dCTP deaminase family
TVNIR_2374	COG0489	protein tyrosine kinase activity
TVNIR_2375	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
TVNIR_2375	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
TVNIR_2376	COG0235	Class ii aldolase
TVNIR_2378	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
TVNIR_2379	COG4657	Part of a membrane complex involved in electron transport
TVNIR_2380	COG2878	Part of a membrane complex involved in electron transport
TVNIR_2382	COG4658	electron transport chain
TVNIR_2384	COG4660	Part of a membrane complex involved in electron transport
TVNIR_2386	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
TVNIR_2390	COG0789	Transcriptional regulator
TVNIR_2392	COG0415	Belongs to the DNA photolyase family
TVNIR_2396	COG0513	Belongs to the DEAD box helicase family
TVNIR_2398	COG0518	GMP synthase (glutamine-hydrolyzing) activity
TVNIR_2398	COG0519	Catalyzes the synthesis of GMP from XMP
TVNIR_2412	COG1262	PFAM Formylglycine-generating sulfatase enzyme
TVNIR_2413	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
TVNIR_2414	COG0709	Synthesizes selenophosphate from selenide and ATP
TVNIR_2417	COG3437	response regulator, receiver
TVNIR_2418	COG0243	molybdopterin cofactor binding
TVNIR_2419	COG2146	nitrite reductase [NAD(P)H] activity
TVNIR_2420	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
TVNIR_2421	COG1116	anion transmembrane transporter activity
TVNIR_2422	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
TVNIR_2423	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
TVNIR_2423	COG1116	anion transmembrane transporter activity
TVNIR_2424	COG3707	response regulator
TVNIR_2428	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
TVNIR_2429	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
TVNIR_2432	COG2010	Cytochrome c
TVNIR_2434	COG1136	(ABC) transporter
TVNIR_2435	COG2239	Acts as a magnesium transporter
TVNIR_2436	COG2239	Acts as a magnesium transporter
TVNIR_2454	COG3028	Belongs to the UPF0307 family
TVNIR_2457	COG3028	Belongs to the UPF0307 family
TVNIR_2462	COG0720	synthase
TVNIR_2463	COG2183	response to ionizing radiation
TVNIR_2475	COG1271	oxidase subunit
TVNIR_2476	COG1294	oxidase, subunit
TVNIR_2478	COG4988	ABC transporter
TVNIR_2479	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
TVNIR_2481	COG0542	response to heat
TVNIR_2483	COG0564	pseudouridine synthase activity
TVNIR_2486	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
TVNIR_2486	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
TVNIR_2487	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
TVNIR_2488	COG0045	succinate-CoA ligase (ADP-forming) activity
TVNIR_2493	COG0745	RESPONSE REGULATOR receiver
TVNIR_2502	COG4964	Belongs to the GSP D family
TVNIR_2508	COG0577	efflux transmembrane transporter activity
TVNIR_2509	COG1136	(ABC) transporter
TVNIR_2517	COG0424	maF-like protein
TVNIR_2520	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
TVNIR_2521	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
TVNIR_2524	COG0495	leucyl-tRNA aminoacylation
TVNIR_2527	COG0058	SHG alpha-glucan phosphorylase activity
TVNIR_2529	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
TVNIR_2537	COG1136	(ABC) transporter
TVNIR_2540	COG0815	Transfers the fatty acyl group on membrane lipoproteins
TVNIR_2541	COG4535	Mg2 and Co2 transporter CorC
TVNIR_2542	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
TVNIR_2543	COG1702	phosphate starvation-inducible protein PhoH
TVNIR_2544	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
TVNIR_2547	COG2814	Major facilitator Superfamily
TVNIR_2548	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
TVNIR_2549	COG0203	ribosomal protein L17
TVNIR_2550	COG0202	RNA polymerase activity
TVNIR_2551	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
TVNIR_2552	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
TVNIR_2553	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
TVNIR_2554	COG0201	protein transport
TVNIR_2555	COG0200	Binds to the 23S rRNA
TVNIR_2556	COG1841	ribosomal large subunit assembly
TVNIR_2557	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
TVNIR_2558	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
TVNIR_2559	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
TVNIR_2560	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
TVNIR_2561	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
TVNIR_2562	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
TVNIR_2563	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
TVNIR_2564	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
TVNIR_2565	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
TVNIR_2566	COG0255	Belongs to the universal ribosomal protein uL29 family
TVNIR_2567	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
TVNIR_2568	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
TVNIR_2569	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
TVNIR_2570	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
TVNIR_2571	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
TVNIR_2572	COG0089	rRNA binding
TVNIR_2573	COG0088	Forms part of the polypeptide exit tunnel
TVNIR_2574	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
TVNIR_2575	COG0051	transcription antitermination factor activity, RNA binding
TVNIR_2576	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
TVNIR_2577	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
TVNIR_2578	COG0049	tRNA binding
TVNIR_2579	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
TVNIR_2580	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
TVNIR_2581	COG0085	RNA polymerase activity
TVNIR_2582	COG0222	ribosome binding
TVNIR_2583	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
TVNIR_2584	COG0081	regulation of translation
TVNIR_2585	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
TVNIR_2592	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
TVNIR_2593	COG0494	nUDIX hydrolase
TVNIR_2594	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
TVNIR_2595	COG0653	protein targeting
TVNIR_2596	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
TVNIR_2598	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
TVNIR_2600	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
TVNIR_2601	COG1181	Belongs to the D-alanine--D-alanine ligase family
TVNIR_2602	COG0812	UDP-N-acetylmuramate dehydrogenase activity
TVNIR_2603	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
TVNIR_2604	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
TVNIR_2605	COG0772	Belongs to the SEDS family
TVNIR_2606	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
TVNIR_2607	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
TVNIR_2608	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
TVNIR_2609	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
TVNIR_2611	COG3116	cell division
TVNIR_2612	COG0275	rRNA processing
TVNIR_2613	COG2001	Belongs to the MraZ family
TVNIR_2616	COG0792	nuclease activity
TVNIR_2617	COG2969	positive regulation of protein catabolic process
TVNIR_2618	COG0277	FAD linked oxidase domain protein
TVNIR_2619	COG0625	glutathione transferase activity
TVNIR_2620	COG2857	Cytochrome c1
TVNIR_2621	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
TVNIR_2622	COG0723	plastoquinol--plastocyanin reductase activity
TVNIR_2624	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
TVNIR_2625	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
TVNIR_2627	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
TVNIR_2629	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
TVNIR_2632	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
TVNIR_2633	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
TVNIR_2634	COG1127	ABC transporter
TVNIR_2641	COG1137	ATPase activity
TVNIR_2646	COG1660	Displays ATPase and GTPase activities
TVNIR_2648	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
TVNIR_2650	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
TVNIR_2653	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
TVNIR_2655	COG2853	Lipoprotein
TVNIR_2656	COG0137	argininosuccinate synthase activity
TVNIR_2658	COG1120	ATPase activity
TVNIR_2659	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
TVNIR_2664	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
TVNIR_2665	COG0508	dehydrogenase complex catalyzes the overall conversion of
TVNIR_2669	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
TVNIR_2670	COG0012	GTP binding
TVNIR_2671	COG0193	aminoacyl-tRNA hydrolase activity
TVNIR_2672	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
TVNIR_2673	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
TVNIR_2674	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
TVNIR_2677	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
TVNIR_2678	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
TVNIR_2681	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
TVNIR_2682	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
TVNIR_2683	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
TVNIR_2684	COG0154	amidase activity
TVNIR_2686	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
TVNIR_2687	COG1077	Cell shape determining protein MreB Mrl
TVNIR_2688	COG1792	Involved in formation and maintenance of cell shape
TVNIR_2689	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
TVNIR_2690	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
TVNIR_2693	COG0859	PFAM glycosyl transferase family 9
TVNIR_2694	COG0859	PFAM glycosyl transferase family 9
TVNIR_2695	COG3642	lipopolysaccharide core region biosynthetic process
TVNIR_2696	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
TVNIR_2697	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
TVNIR_2697	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
TVNIR_2698	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
TVNIR_2701	COG1519	Transferase
TVNIR_2709	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
TVNIR_2710	COG2153	protein acetylation
TVNIR_2712	COG0133	tryptophan synthase activity
TVNIR_2713	COG3850	Histidine kinase
TVNIR_2713	COG3850	Histidine kinase
TVNIR_2714	COG2197	response regulator
TVNIR_2716	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
TVNIR_2716	COG1648	precorrin-2 dehydrogenase activity
TVNIR_2720	COG0450	alkyl hydroperoxide reductase
TVNIR_2722	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
TVNIR_2723	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
TVNIR_2724	COG0328	RNA-DNA hybrid ribonuclease activity
TVNIR_2730	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
TVNIR_2732	COG0432	Pfam Uncharacterised protein family UPF0047
TVNIR_2736	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
TVNIR_2739	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
TVNIR_2741	COG1858	cytochrome C peroxidase
TVNIR_2745	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
TVNIR_2748	COG4206	TonB-dependent receptor
TVNIR_2750	COG0446	pyridine nucleotide-disulphide oxidoreductase
TVNIR_2752	COG2204	response regulator
TVNIR_2753	COG3852	Histidine kinase
TVNIR_2756	COG1136	(ABC) transporter
TVNIR_2757	COG4591	ABC-type transport system involved in lipoprotein release permease component
TVNIR_2758	COG1136	(ABC) transporter
TVNIR_2759	COG0577	efflux transmembrane transporter activity
TVNIR_2765	COG2095	MarC family integral membrane protein
TVNIR_2772	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
TVNIR_2773	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
TVNIR_2775	COG0544	peptidyl-prolyl cis-trans isomerase activity
TVNIR_2776	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
TVNIR_2777	COG1923	regulation of RNA biosynthetic process
TVNIR_2778	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
TVNIR_2779	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
TVNIR_2780	COG0860	N-Acetylmuramoyl-L-alanine amidase
TVNIR_2781	COG0802	atpase or kinase
TVNIR_2782	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
TVNIR_2782	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
TVNIR_2785	COG3118	belongs to the thioredoxin family
TVNIR_2788	COG0330	HflC and HflK could
TVNIR_2791	COG1763	Mo-molybdopterin cofactor biosynthetic process
TVNIR_2792	COG0303	'Molybdopterin
TVNIR_2798	COG1136	(ABC) transporter
TVNIR_2805	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
TVNIR_2808	COG0166	Belongs to the GPI family
TVNIR_2809	COG0297	glycogen (starch) synthase activity
TVNIR_2810	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
TVNIR_2811	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
TVNIR_2812	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
TVNIR_2813	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
TVNIR_2814	COG1428	Deoxynucleoside kinase
TVNIR_2815	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
TVNIR_2816	COG0617	tRNA 3'-terminal CCA addition
TVNIR_2818	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
TVNIR_2819	COG0625	glutathione transferase activity
TVNIR_2824	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
TVNIR_2825	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
TVNIR_2826	COG0363	glucosamine-6-phosphate deaminase activity
TVNIR_2829	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
TVNIR_2837	COG1484	DNA-dependent DNA replication
TVNIR_2845	COG3041	Addiction module toxin RelE StbE family
TVNIR_2848	COG2226	methyltransferase
TVNIR_2856	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
TVNIR_2857	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
TVNIR_2858	COG1993	acr, cog1993
TVNIR_2869	COG4974	Belongs to the 'phage' integrase family
TVNIR_2870	COG0517	IMP dehydrogenase activity
TVNIR_2872	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
TVNIR_2876	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
TVNIR_2876	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
TVNIR_2877	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
TVNIR_2878	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
TVNIR_2882	COG3360	Dodecin
TVNIR_2885	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
TVNIR_2888	COG1215	transferase activity, transferring glycosyl groups
TVNIR_2891	COG2204	response regulator
TVNIR_2894	COG2226	methyltransferase
TVNIR_2894	COG2267	carboxylic ester hydrolase activity
TVNIR_2895	COG2433	Pfam Transposase IS66
TVNIR_2898	COG0129	dihydroxy-acid dehydratase activity
TVNIR_2901	COG1611	Belongs to the LOG family
TVNIR_2914	COG0123	including yeast histone deacetylase and acetoin utilization protein
TVNIR_2915	COG0045	succinate-CoA ligase (ADP-forming) activity
TVNIR_2915	COG1042	CoA-binding domain protein
TVNIR_2915	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
TVNIR_2918	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
TVNIR_2920	COG2361	Protein of unknown function DUF86
TVNIR_2925	COG1686	Belongs to the peptidase S11 family
TVNIR_2926	COG0398	Pfam SNARE associated Golgi protein
TVNIR_2927	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
TVNIR_2929	COG1674	ftsk spoiiie
TVNIR_2930	COG0492	ferredoxin-NADP+ reductase activity
TVNIR_2932	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
TVNIR_2934	COG4221	oxidoreductase activity
TVNIR_2936	COG2133	pyrroloquinoline quinone binding
TVNIR_2937	COG0587	DNA-directed DNA polymerase activity
TVNIR_2938	COG2210	Belongs to the sulfur carrier protein TusA family
TVNIR_2944	COG1192	Involved in chromosome partitioning
TVNIR_2947	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
TVNIR_2951	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
TVNIR_2953	COG0436	Aminotransferase
TVNIR_2957	COG1238	metal cluster binding
TVNIR_2958	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
TVNIR_2959	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
TVNIR_2962	COG1366	Belongs to the anti-sigma-factor antagonist family
TVNIR_2963	COG0585	pseudouridine synthase activity
TVNIR_2965	COG1199	ATP-dependent helicase activity
TVNIR_2967	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
TVNIR_2970	COG0791	NLP P60 protein
TVNIR_2972	COG0521	Mo-molybdopterin cofactor biosynthetic process
TVNIR_2976	COG2166	iron-sulfur cluster assembly
TVNIR_2978	COG0583	DNA-binding transcription factor activity
TVNIR_2991	COG4451	ribulose bisphosphate carboxylase, small
TVNIR_2992	COG1850	ribulose-bisphosphate carboxylase activity
TVNIR_2994	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
TVNIR_3000	COG4681	YaeQ
TVNIR_3002	COG0583	DNA-binding transcription factor activity
TVNIR_3003	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
TVNIR_3009	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
TVNIR_3014	COG1999	signal sequence binding
TVNIR_3017	COG2391	methyltransferase activity
TVNIR_3018	COG0109	protoheme IX farnesyltransferase activity
TVNIR_3019	COG1612	heme a metabolic process
TVNIR_3031	COG2766	serine protein kinase
TVNIR_3032	COG2718	Belongs to the UPF0229 family
TVNIR_3033	COG2719	SpoVR family
TVNIR_3034	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
TVNIR_3039	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
TVNIR_3043	COG0545	Peptidyl-prolyl cis-trans isomerase
TVNIR_3049	COG2951	lytic endotransglycosylase activity
TVNIR_3055	COG1917	Cupin 2, conserved barrel domain protein
TVNIR_3055	COG2207	Transcriptional regulator
TVNIR_3058	COG2249	NAD(P)H dehydrogenase (quinone) activity
TVNIR_3064	COG2234	aminopeptidase activity
TVNIR_3066	COG1960	acyl-CoA dehydrogenase activity
TVNIR_3067	COG2169	Transcriptional regulator
TVNIR_3069	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
TVNIR_3069	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
TVNIR_3070	COG3588	fructose-bisphosphate aldolase
TVNIR_3072	COG0129	dihydroxy-acid dehydratase activity
TVNIR_3083	COG0822	iron-sulfur transferase activity
TVNIR_3085	COG0518	GMP synthase (glutamine-hydrolyzing) activity
TVNIR_3085	COG0519	Catalyzes the synthesis of GMP from XMP
TVNIR_3088	COG1570	exodeoxyribonuclease VII activity
TVNIR_3089	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
TVNIR_3090	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
TVNIR_3091	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
TVNIR_3093	COG4191	Histidine kinase
TVNIR_3094	COG2204	response regulator
TVNIR_3097	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
TVNIR_3100	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
TVNIR_3103	COG2308	Evidence 4 Homologs of previously reported genes of
TVNIR_3106	COG1185	polyribonucleotide nucleotidyltransferase activity
TVNIR_3107	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
TVNIR_3108	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
TVNIR_3109	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
TVNIR_3110	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
TVNIR_3111	COG2251	uridine kinase activity
TVNIR_3111	COG0195	Participates in both transcription termination and antitermination
TVNIR_3113	COG1007	ATP synthesis coupled electron transport
TVNIR_3116	COG0713	ATP synthesis coupled electron transport
TVNIR_3118	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
TVNIR_3119	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
TVNIR_3120	COG1034	ATP synthesis coupled electron transport
TVNIR_3123	COG0649	NAD binding
TVNIR_3124	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
TVNIR_3125	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
TVNIR_3126	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
TVNIR_3128	COG0149	triose-phosphate isomerase activity
TVNIR_3129	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
TVNIR_3130	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
TVNIR_3131	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
TVNIR_3132	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
TVNIR_3133	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
TVNIR_3134	COG1534	Rna-binding protein
TVNIR_3136	COG0505	Belongs to the CarA family
TVNIR_3138	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
TVNIR_3140	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
TVNIR_3143	COG0688	phosphatidylethanolamine metabolic process
TVNIR_3145	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
TVNIR_3146	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
TVNIR_3147	COG1509	lysine 2,3-aminomutase activity
TVNIR_3149	COG2200	EAL domain
TVNIR_3150	COG0484	heat shock protein binding
TVNIR_3151	COG0443	Heat shock 70 kDa protein
TVNIR_3152	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
TVNIR_3153	COG1420	regulation of RNA biosynthetic process
TVNIR_3154	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
TVNIR_3155	COG0497	DNA recombination
TVNIR_3156	COG0735	belongs to the Fur family
TVNIR_3157	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
TVNIR_3158	COG2914	Belongs to the UPF0125 (RnfH) family
TVNIR_3159	COG2867	negative regulation of translational initiation
TVNIR_3160	COG0733	neurotransmitter:sodium symporter activity
TVNIR_3161	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
TVNIR_3162	COG1858	cytochrome C peroxidase
TVNIR_3165	COG0488	(ABC) transporter
TVNIR_3169	COG0523	cobalamin synthesis protein
TVNIR_3173	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
TVNIR_3178	COG2135	peptidase activity
TVNIR_3180	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
TVNIR_3182	COG2833	Protein of unknown function (DUF455)
TVNIR_3183	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
TVNIR_3187	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
TVNIR_3188	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
TVNIR_3191	COG4191	Histidine kinase
TVNIR_3192	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
TVNIR_3193	COG0501	Belongs to the peptidase M48B family
TVNIR_3202	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
TVNIR_3204	COG0518	GMP synthase (glutamine-hydrolyzing) activity
TVNIR_3204	COG0519	Catalyzes the synthesis of GMP from XMP
TVNIR_3205	COG0525	valine-tRNA ligase activity
TVNIR_3208	COG2027	D-alanyl-D-alanine carboxypeptidase
TVNIR_3211	COG5265	(ABC) transporter
TVNIR_3212	COG1403	HNH endonuclease
TVNIR_3215	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
TVNIR_3218	COG0456	acetyltransferase
TVNIR_3219	COG1573	uracil-dna glycosylase
TVNIR_3220	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
TVNIR_3221	COG1183	phosphatidylcholine synthase activity
TVNIR_3223	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
TVNIR_3225	COG0028	Belongs to the TPP enzyme family
TVNIR_3231	COG0095	Lipoate-protein ligase
TVNIR_3240	COG4771	TonB-dependent receptor
TVNIR_3241	COG0509	glycine decarboxylation via glycine cleavage system
TVNIR_3243	COG0509	glycine decarboxylation via glycine cleavage system
TVNIR_3244	COG2048	Heterodisulfide reductase, subunit B
TVNIR_3250	COG0425	Belongs to the sulfur carrier protein TusA family
TVNIR_3251	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
TVNIR_3253	COG4783	chaperone-mediated protein folding
TVNIR_3255	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
TVNIR_3256	COG0305	Participates in initiation and elongation during chromosome replication
TVNIR_3257	COG0359	binds to the 23S rRNA
TVNIR_3259	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
TVNIR_3260	COG0360	Binds together with S18 to 16S ribosomal RNA
TVNIR_3261	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
TVNIR_3262	COG0557	exoribonuclease II activity
TVNIR_3263	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
TVNIR_3264	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
TVNIR_3266	COG0330	HflC and HflK could
TVNIR_3267	COG0330	HflC and HflK could
TVNIR_3269	COG0435	Glutathione S-transferase
TVNIR_3275	COG3485	protocatechuate 3,4-dioxygenase
TVNIR_3281	COG3409	Peptidoglycan-binding domain 1 protein
TVNIR_3281	COG3267	Type II secretory pathway component ExeA
TVNIR_3286	COG1051	belongs to the nudix hydrolase family
TVNIR_3287	COG0210	DNA helicase
TVNIR_3307	COG3550	peptidyl-serine autophosphorylation
TVNIR_3310	COG3609	addiction module antidote protein, CC2985 family
TVNIR_3316	COG3311	Transcriptional regulator
TVNIR_3317	COG3012	SEC-C Motif Domain Protein
TVNIR_3319	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
TVNIR_3321	COG3311	Transcriptional regulator
TVNIR_3329	COG1082	Xylose isomerase domain protein TIM barrel
TVNIR_3335	COG0811	peptide transport
TVNIR_3343	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
TVNIR_3344	COG0604	alcohol dehydrogenase
TVNIR_3355	COG0446	pyridine nucleotide-disulphide oxidoreductase
TVNIR_3363	COG4716	Myosin-crossreactive antigen
TVNIR_3364	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
TVNIR_3365	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
TVNIR_3366	COG0602	queuosine metabolic process
TVNIR_3369	COG0823	Involved in the tonB-independent uptake of proteins
TVNIR_3373	COG0824	Thioesterase
TVNIR_3374	COG2255	four-way junction helicase activity
TVNIR_3375	COG0632	four-way junction helicase activity
TVNIR_3376	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
TVNIR_3377	COG0217	transcriptional regulatory protein
TVNIR_3379	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
TVNIR_3385	COG0300	oxidoreductase activity
TVNIR_3386	COG2715	membrane protein required for spore maturation
TVNIR_3387	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
TVNIR_3392	COG0442	prolyl-tRNA aminoacylation
TVNIR_3393	COG1393	Belongs to the ArsC family
TVNIR_3396	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
TVNIR_3397	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
TVNIR_3399	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
TVNIR_3400	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
TVNIR_3402	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
TVNIR_3403	COG0312	modulator of DNA gyrase
TVNIR_3405	COG0312	modulator of DNA gyrase
TVNIR_3406	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
TVNIR_3408	COG1530	ribonuclease E activity
TVNIR_3415	COG0616	signal peptide processing
TVNIR_3416	COG0326	Molecular chaperone. Has ATPase activity
TVNIR_3417	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
TVNIR_3418	COG2010	Cytochrome c
TVNIR_3421	COG0335	large ribosomal subunit rRNA binding
TVNIR_3422	COG0336	Belongs to the RNA methyltransferase TrmD family
TVNIR_3423	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
TVNIR_3424	COG0228	four-way junction DNA binding
TVNIR_3425	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
TVNIR_3426	COG4137	Cytochrome C assembly protein
TVNIR_3427	COG4536	flavin adenine dinucleotide binding
TVNIR_3432	COG1592	Rubrerythrin
TVNIR_3433	COG1722	exodeoxyribonuclease VII activity
TVNIR_3434	COG0142	geranyltranstransferase activity
TVNIR_3435	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
TVNIR_3436	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
TVNIR_3437	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
TVNIR_3439	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
TVNIR_3440	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
TVNIR_3442	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
TVNIR_3443	COG0739	heme binding
TVNIR_3445	COG0316	Belongs to the HesB IscA family
TVNIR_3446	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
TVNIR_3449	COG0494	nUDIX hydrolase
TVNIR_3452	COG0352	thiamine-phosphate diphosphorylase activity
TVNIR_3452	COG0351	phosphomethylpyrimidine kinase
TVNIR_3453	COG0352	thiamine-phosphate diphosphorylase activity
TVNIR_3454	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
TVNIR_3455	COG0730	response to heat
TVNIR_3456	COG0308	aminopeptidase N
TVNIR_3458	COG0084	hydrolase, TatD family'
TVNIR_3459	COG0271	Belongs to the BolA IbaG family
TVNIR_3465	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
TVNIR_3467	COG1470	cell adhesion involved in biofilm formation
TVNIR_3467	COG1388	LysM domain
TVNIR_3476	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
TVNIR_3478	COG0828	Belongs to the bacterial ribosomal protein bS21 family
TVNIR_3479	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
TVNIR_3480	COG0232	Belongs to the dGTPase family. Type 2 subfamily
TVNIR_3482	COG1120	ATPase activity
TVNIR_3483	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
TVNIR_3484	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
TVNIR_3485	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
TVNIR_3494	COG4206	TonB-dependent receptor
TVNIR_3495	COG0358	DNA primase activity
TVNIR_3496	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
TVNIR_3515	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
TVNIR_3516	COG4941	Belongs to the sigma-70 factor family
TVNIR_3518	COG3795	YCII-related domain
TVNIR_3540	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
TVNIR_3544	COG0463	Glycosyl transferase, family 2
TVNIR_3547	COG1058	Belongs to the CinA family
TVNIR_3547	COG1546	Belongs to the CinA family
TVNIR_3548	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
TVNIR_3550	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
TVNIR_3551	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
TVNIR_3552	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
TVNIR_3553	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
TVNIR_3555	COG0018	arginyl-trna synthetase
TVNIR_3557	COG1643	Atp-dependent helicase
TVNIR_3563	COG0735	belongs to the Fur family
TVNIR_3565	COG4772	TonB-dependent receptor
TVNIR_3568	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
TVNIR_3574	COG5001	Diguanylate cyclase
TVNIR_3574	COG5002	protein histidine kinase activity
TVNIR_3575	COG0235	Class ii aldolase
TVNIR_3576	COG0121	glutamine amidotransferase
TVNIR_3578	COG1067	ATP-dependent peptidase activity
TVNIR_3580	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
TVNIR_3582	COG0640	Transcriptional regulator
TVNIR_3585	COG1484	DNA-dependent DNA replication
TVNIR_3588	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
TVNIR_3592	COG0315	cyclic pyranopterin monophosphate synthase activity
TVNIR_3593	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
TVNIR_3595	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
TVNIR_3597	COG0071	Belongs to the small heat shock protein (HSP20) family
TVNIR_3599	COG1561	YicC-like family, N-terminal region
TVNIR_3600	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
TVNIR_3601	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
TVNIR_3602	COG0635	Involved in the biosynthesis of porphyrin-containing compound
TVNIR_3605	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
TVNIR_3609	COG1047	Peptidyl-prolyl cis-trans
TVNIR_3614	COG2046	Belongs to the sulfate adenylyltransferase family
TVNIR_3618	COG0243	molybdopterin cofactor binding
TVNIR_3619	COG0437	4 iron, 4 sulfur cluster binding
TVNIR_3620	COG3302	dmso reductase anchor subunit
TVNIR_3622	COG0563	adenylate kinase activity
TVNIR_3623	COG0205	6-phosphofructokinase activity
TVNIR_3624	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
TVNIR_3627	COG0617	tRNA 3'-terminal CCA addition
TVNIR_3628	COG1309	transcriptional regulator
TVNIR_3629	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
TVNIR_3630	COG1538	Outer membrane efflux protein
TVNIR_3633	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
TVNIR_3636	COG1444	tRNA N-acetyltransferase activity
TVNIR_3637	COG1278	Cold shock
TVNIR_3638	COG0174	glutamine synthetase
TVNIR_3640	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
TVNIR_3642	COG0752	glycyl-tRNA synthetase alpha subunit
TVNIR_3643	COG0751	glycine-tRNA ligase activity
TVNIR_3645	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
TVNIR_3646	COG0084	hydrolase, TatD family'
TVNIR_3649	COG0667	Aldo Keto reductase
TVNIR_3652	COG3954	Phosphoribulokinase
TVNIR_3653	COG0471	metal ion transport
TVNIR_3653	COG3273	potassium ion transport
TVNIR_3655	COG0589	response to stress
TVNIR_3656	COG0220	tRNA (guanine-N7-)-methyltransferase activity
TVNIR_3657	COG2022	thiamine diphosphate biosynthetic process
TVNIR_3670	COG1741	Belongs to the pirin family
TVNIR_3673	COG2226	methyltransferase
TVNIR_3677	COG3609	addiction module antidote protein, CC2985 family
TVNIR_3685	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
TVNIR_3694	COG5001	Diguanylate cyclase
TVNIR_3698	COG0194	GDP metabolic process
TVNIR_3699	COG1758	RNA polymerase activity
TVNIR_3700	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
TVNIR_3704	COG0037	tRNA processing
TVNIR_3705	COG0445	tRNA wobble uridine modification
TVNIR_3706	COG0357	Ribosomal RNA small subunit methyltransferase G
TVNIR_3707	COG1192	Involved in chromosome partitioning
TVNIR_3708	COG1475	DNA binding
TVNIR_3710	COG0356	it plays a direct role in the translocation of protons across the membrane
TVNIR_3712	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
TVNIR_3713	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
TVNIR_3714	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
TVNIR_3715	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
TVNIR_3716	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
TVNIR_3717	COG0355	proton-transporting ATP synthase activity, rotational mechanism
TVNIR_3718	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
TVNIR_3719	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
TVNIR_3721	COG1628	Protein of unknown function DUF99
TVNIR_3724	COG3100	YcgL domain-containing protein
TVNIR_3724	COG0561	phosphatase activity
TVNIR_3726	COG0793	Belongs to the peptidase S41A family
TVNIR_3727	COG4942	peptidase
TVNIR_3728	COG0640	Transcriptional regulator
TVNIR_3729	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
TVNIR_3732	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
TVNIR_3733	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
TVNIR_3734	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
TVNIR_3736	COG3852	Histidine kinase
TVNIR_3739	COG1611	Belongs to the LOG family
TVNIR_3742	COG1999	signal sequence binding
TVNIR_3744	COG0218	Necessary for normal cell division and for the maintenance of normal septation
TVNIR_3749	COG0367	asparagine synthase
TVNIR_3750	COG0540	Belongs to the ATCase OTCase family
TVNIR_3751	COG1335	isochorismatase
TVNIR_3754	COG1846	Transcriptional regulator
TVNIR_3756	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
TVNIR_3759	COG0708	Exodeoxyribonuclease III
TVNIR_3760	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
TVNIR_3762	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
TVNIR_3766	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
TVNIR_3767	COG0513	Belongs to the DEAD box helicase family
TVNIR_3769	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
TVNIR_3771	COG0205	6-phosphofructokinase activity
TVNIR_3774	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
TVNIR_3775	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
TVNIR_3776	COG0405	Gamma-glutamyltransferase
TVNIR_3783	COG0508	dehydrogenase complex catalyzes the overall conversion of
TVNIR_3785	COG0210	DNA helicase
TVNIR_3790	COG0446	pyridine nucleotide-disulphide oxidoreductase
TVNIR_3796	COG1490	D-aminoacyl-tRNA deacylase activity
TVNIR_3797	COG1394	ATPase activity, coupled to movement of substances
TVNIR_3798	COG1156	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit
TVNIR_3799	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
TVNIR_3800	COG1390	Produces ATP from ADP in the presence of a proton gradient across the membrane
TVNIR_3807	COG0706	membrane insertase activity
TVNIR_3808	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
TVNIR_3809	COG0594	ribonuclease P activity
TVNIR_3810	COG0230	Belongs to the bacterial ribosomal protein bL34 family
TVNIR_3811	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
TVNIR_3812	COG0592	DNA-directed DNA polymerase activity
TVNIR_3813	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
TVNIR_3816	COG0187	DNA topoisomerase II activity
TVNIR_3817	COG1704	LemA family
TVNIR_3819	COG0339	signal peptide processing
TVNIR_3820	COG0708	Exodeoxyribonuclease III
TVNIR_3823	COG2862	Uncharacterized protein family, UPF0114
TVNIR_3824	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
TVNIR_3827	COG0543	2 iron, 2 sulfur cluster binding
TVNIR_3827	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
TVNIR_3830	COG0165	Argininosuccinate lyase
TVNIR_3845	COG3031	protein transport across the cell outer membrane
TVNIR_3846	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
TVNIR_3847	COG2197	response regulator
TVNIR_3849	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
TVNIR_3850	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family