locus-tag	class	description
THITH_00005	ENOG4105CI4	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity)
THITH_00010	ENOG4105CZ8	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity)
THITH_00015	ENOG4105C3X	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity)
THITH_00020	ENOG4105C7D	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
THITH_00025	ENOG4108V0P	LemA family
THITH_00035	ENOG4105DGW	oligopeptidase A
THITH_00040	ENOG4105CGK	Exodeoxyribonuclease III
THITH_00050	ENOG4105D3H	Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity)
THITH_00060	ENOG4108EX3	reductase
THITH_00070	ENOG4105D6W	Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity)
THITH_00075	ENOG4105CH7	arginosuccinase
THITH_00110	ENOG4108WWZ	General secretion pathway protein J
THITH_00115	ENOG4105X5Z	General secretion pathway protein I
THITH_00120	ENOG4105VWV	general secretion pathway protein h
THITH_00125	ENOG4108VAU	general secretion pathway protein G
THITH_00130	ENOG4105D7Q	type ii secretion system
THITH_00135	ENOG4107QHF	type ii secretion system protein e
THITH_00140	ENOG4105GVR	general secretion pathway protein D
THITH_00150	ENOG4105CJI	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity)
THITH_00155	ENOG4105WH1	Two component transcriptional regulator luxr family
THITH_00170	ENOG4108IAJ	Nad-dependent epimerase dehydratase
THITH_00210	ENOG4105BZ1	(ABC) transporter
THITH_00230	ENOG4105BZ1	(ABC) transporter
THITH_00250	ENOG4107ZIC	Glycerol-3-phosphate cytidylyltransferase
THITH_00255	ENOG4107RZX	Teichoic acid biosynthesis protein
THITH_00360	ENOG4105CKK	Glycosyl transferase, family 2
THITH_00375	ENOG4105KHS	type IV fimbrial pilin protein
THITH_00400	ENOG4105C8S	subunit m
THITH_00415	ENOG4105C6Y	Udp-glucose 6-dehydrogenase
THITH_00420	ENOG4107QKV	phosphomannomutase
THITH_00455	ENOG4105KPZ	phosphoribosyl-atp pyrophosphatase
THITH_00460	ENOG4105C0S	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity)
THITH_00465	ENOG4105CJV	Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase
THITH_00470	ENOG4108UJE	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity)
THITH_00475	ENOG4105ECC	imidazole-glycerol-phosphate dehydratase
THITH_00500	ENOG4105CU5	Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity)
THITH_00505	ENOG4107R6G	Catalyzes the S-adenosylmethionine monomethyl esterification of trans-aconitate (By similarity)
THITH_00510	ENOG4105E4Z	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity)
THITH_00515	ENOG4105CT0	Protein of unknown function, DUF484
THITH_00520	ENOG4108IYS	Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity)
THITH_00525	ENOG4108R5P	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery (By similarity)
THITH_00530	ENOG4105C4N	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis (By similarity)
THITH_00540	ENOG4105DDZ	Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity)
THITH_00550	ENOG4105CNK	Required, probably indirectly, for the hydroxylation of 2-octaprenylphenol to 2-octaprenyl-6-hydroxy-phenol, the fourth step in ubiquinone biosynthesis (By similarity)
THITH_00555	ENOG4105CSR	polyphosphate kinase 2
THITH_00560	ENOG4105C8S	subunit m
THITH_00565	ENOG4108JPZ	Monovalent cation H antiporter subunit D
THITH_00570	ENOG4108JPZ	Monovalent cation H antiporter subunit D
THITH_00575	ENOG4105MKQ	Monovalent cation H antiporter subunit C
THITH_00590	ENOG4105KJM	monovalent cation h antiporter subunit g
THITH_00605	ENOG4105C1Q	protoporphyrinogen oxidase
THITH_00610	ENOG4105ERD	Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity)
THITH_00620	ENOG4105W0E	50S ribosomal protein L33
THITH_00625	ENOG4105KDC	50s ribosomal protein l28
THITH_00630	ENOG4105C0M	Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle (By similarity)
THITH_00645	ENOG4108JJA	ABC, transporter
THITH_00655	ENOG4105WH1	Two component transcriptional regulator luxr family
THITH_00705	ENOG4105BZU	Histidine kinase
THITH_00710	ENOG41085AF	Cytochrome
THITH_00715	ENOG4105CE2	Aldehyde oxidase and xanthine dehydrogenase, molybdopterin binding
THITH_00725	ENOG4105RX7	peptidase S8 and S53, subtilisin, kexin, sedolisin
THITH_00735	ENOG4105DSY	exodeoxyribonuclease V, gamma
THITH_00740	ENOG4107QKA	exodeoxyribonuclease V beta
THITH_00745	ENOG4107QYX	exodeoxyribonuclease v alpha
THITH_00755	ENOG41089UC	methyltransferase, type 11
THITH_00770	ENOG4105CHG	glycolate oxidase (iron-sulfur subunit)
THITH_00775	ENOG4107QR9	Iron-sulfur cluster binding protein
THITH_00780	ENOG4108ZZK	Is involved in L-lactate degradation and allows cells to grow with lactate as the sole carbon source (By similarity)
THITH_00785	ENOG4105DAA	L-lactate
THITH_00790	ENOG41089UC	methyltransferase, type 11
THITH_00800	ENOG4105EMN	RNA polymerase sigma factor
THITH_00820	ENOG4108I5C	dEAD DEAH box helicase
THITH_00910	ENOG4105EAH	synthase
THITH_00915	ENOG4105KK9	This protein binds to 23S rRNA in the presence of protein L20 (By similarity)
THITH_00920	ENOG4105K46	50S ribosomal protein l27
THITH_00925	ENOG4105C9R	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
THITH_00930	ENOG4105CGT	Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity)
THITH_00935	ENOG4105KQV	Binds directly to 16S ribosomal RNA (By similarity)
THITH_00945	ENOG4105CJR	Integral membrane protein (MviN
THITH_00950	ENOG4105DTN	riboflavin biosynthesis protein ribF
THITH_00955	ENOG4105C07	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity)
THITH_00960	ENOG4105M02	This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity)
THITH_00965	ENOG41090X3	Peptidyl-prolyl cis-trans isomerase
THITH_00970	ENOG4105C48	Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity)
THITH_00975	ENOG4105CKI	cobalamin synthesis protein
THITH_00990	ENOG4105DW3	Response regulator receiver modulated metal dependent phosphohydrolase
THITH_01010	ENOG4105C2T	Binding-protein-dependent transport systems, inner membrane component
THITH_01035	ENOG4105CGH	5'-nucleotidase
THITH_01050	ENOG4105VXN	addiction module toxin, RelE StbE family
THITH_01060	ENOG4105YES	addiction module antidote protein
THITH_01100	ENOG4105BZK	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair (By similarity)
THITH_01145	ENOG4107R3N	Filamentation induced by cAMP protein fic
THITH_01155	ENOG4108I5C	dEAD DEAH box helicase
THITH_01170	ENOG4105G5W	regulator Fur family
THITH_01185	ENOG4105CA8	Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity)
THITH_01190	ENOG4105CZ1	Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity)
THITH_01195	ENOG4108YV4	Universal stress protein
THITH_01205	ENOG4105CJE	phosphoribulokinase (EC 2.7.1.19)
THITH_01220	ENOG4105CPC	Aldo Keto reductase
THITH_01235	ENOG4105F8V	Hydrolase, tatD family
THITH_01240	ENOG4105CUZ	uba thif-type nad fad binding protein
THITH_01250	ENOG4105C38	Glycyl-tRNA synthetase beta subunit
THITH_01255	ENOG4108HMW	glycyl-tRNA synthetase, alpha subunit
THITH_01265	ENOG41076HS	cation diffusion facilitator family transporter
THITH_01270	ENOG4105C5F	glutamine synthetase
THITH_01275	ENOG4105VEQ	Cold shock protein
THITH_01280	ENOG4105E0I	Catalyzes the formation of N(4)-acetylcytidine (ac(4)C) at the wobble position of tRNA(Met), by using acetyl-CoA as an acetyl donor and ATP (or GTP) (By similarity)
THITH_01285	ENOG4105C5H	ABC transporter
THITH_01310	ENOG4105DFG	type I secretion outer membrane protein
THITH_01315	ENOG4105E26	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity)
THITH_01320	ENOG4108WUH	Transcriptional regulator, TetR family
THITH_01325	ENOG4105D4J	Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate
THITH_01340	ENOG4105CM1	Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity)
THITH_01345	ENOG4107R15	K00850 6-phosphofructokinase 1 EC 2.7.1.11
THITH_01350	ENOG4105CC8	Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity)
THITH_01370	ENOG4108KDI	dmso reductase anchor subunit
THITH_01375	ENOG4105QA4	4Fe-4S Ferredoxin, iron-sulfur binding domain protein
THITH_01380	ENOG4105DB1	molybdopterin oxidoreductase
THITH_01400	ENOG4107RIQ	Sulfate adenylate transferase
THITH_01425	ENOG4108YZY	peptidylprolyl cis-trans isomerase
THITH_01430	ENOG4105C1J	atp-dependent rna helicase
THITH_01435	ENOG4105K63	Thioredoxin
THITH_01455	ENOG4105CSA	Coproporphyrinogen iii oxidase
THITH_01460	ENOG4108V82	Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity)
THITH_01465	ENOG4105ED0	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity)
THITH_01470	ENOG4105DSJ	YicC domain protein
THITH_01485	ENOG4105C0H	protease
THITH_01490	ENOG4108ZAF	Molybdopterin
THITH_01495	ENOG4105M00	molybdopterin converting factor, subunit 1
THITH_01500	ENOG4108YXW	Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity)
THITH_01515	ENOG4105CEN	a g-specific adenine glycosylase
THITH_01520	ENOG4105KMG	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes (By similarity)
THITH_01530	ENOG4105DFP	Integrase
THITH_01535	ENOG4107QUV	Domain protein
THITH_01625	ENOG4105VM8	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding (By similarity)
THITH_01680	ENOG4105CKI	cobalamin synthesis protein
THITH_01715	ENOG4105DAN	ATP-dependent protease
THITH_01725	ENOG4105E7A	Glutamine amidotransferase
THITH_01730	ENOG4107W7X	Aldolase
THITH_01735	ENOG4105BZU	Histidine kinase
THITH_01755	ENOG4107QKV	phosphomannomutase
THITH_01770	ENOG4107S45	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity)
THITH_01785	ENOG4105CHB	tonB-dependent Receptor
THITH_01795	ENOG4105MYN	Zinc uptake regulation protein
THITH_01805	ENOG4105CHQ	Murein-degrading enzyme that degrades murein glycan strands and insoluble, high-molecular weight murein sacculi, with the concomitant formation of a 1,6-anhydromuramoyl product. Lytic transglycosylases (LTs) play an integral role in the metabolism of the peptidoglycan (PG) sacculus. Their lytic action creates space within the PG sacculus to allow for its expansion as well as for the insertion of various structures such as secretion systems and flagella (By similarity)
THITH_01820	ENOG4105CKI	cobalamin synthesis protein
THITH_01840	ENOG4105FDK	ABC transporter
THITH_01850	ENOG4105CJX	Molecular chaperone. Has ATPase activity (By similarity)
THITH_01885	ENOG4105DZR	Type I site-specific deoxyribonuclease
THITH_01920	ENOG4105CE1	Ferrous iron transport protein b
THITH_01930	ENOG4105VDM	plasmid maintenance system antidote protein, xre family
THITH_01970	ENOG4105CQ7	ATP-dependent helicase
THITH_01980	ENOG4105C75	arginyL-tRNA synthetase
THITH_01985	ENOG4105C25	Primosomal protein n'
THITH_01990	ENOG4105C15	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity)
THITH_01995	ENOG4105W8H	transhydrogenase (subunit alpha
THITH_02000	ENOG4108IIE	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity)
THITH_02010	ENOG4105CFX	Catalyzes the ferrous insertion into protoporphyrin IX (By similarity)
THITH_02015	ENOG4105CEV	competence damage-inducible protein
THITH_02035	ENOG4105CKK	Glycosyl transferase, family 2
THITH_02040	ENOG4105SA9	Catalyzes the transfer of the L-Ara4N moiety of the glycolipid undecaprenyl phosphate-alpha-L-Ara4N to lipid A. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides (By similarity)
THITH_02060	ENOG4108T5I	Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity)
THITH_02070	ENOG4105CM1	Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity)
THITH_02075	ENOG4105C1W	two component, sigma54 specific, transcriptional regulator, Fis family
THITH_02080	ENOG4105C6R	Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity)
THITH_02085	ENOG4105CVM	Molybdenum cofactor synthesis domain protein
THITH_02095	ENOG4108MG3	formate dehydrogenase
THITH_02105	ENOG4105QAX	Iron-sulfur
THITH_02110	ENOG4108IEG	Formate dehydrogenase Alpha subunit
THITH_02140	ENOG4107H9G	Necessary for formate dehydrogenase activity (By similarity)
THITH_02185	ENOG4108JCI	Transcriptional regulator
THITH_02210	ENOG4105M0J	Toxic component of a toxin-antitoxin (TA) module. A
THITH_02285	ENOG4108NEV	two component transcriptional regulator, LytTR family
THITH_02300	ENOG4105NFY	transcriptional modulator of maze toxin, mazf
THITH_02305	ENOG4105E6M	Sulphatase-modifying factor protein
THITH_02310	ENOG4105N2G	alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
THITH_02315	ENOG4105D0I	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity)
THITH_02340	ENOG4105DP0	ferredoxin-NADP reductase
THITH_02355	ENOG4107S7U	Sulfide dehydrogenase
THITH_02375	ENOG4105XJC	Two component transcriptional regulator (Winged helix family
THITH_02380	ENOG4105ES5	Histidine kinase
THITH_02385	ENOG4105MWK	D-amino acid dehydrogenase, small subunit
THITH_02405	ENOG4105D9I	Responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6 (By similarity)
THITH_02410	ENOG4105D1S	lipid A biosynthesis
THITH_02415	ENOG4105D8A	3-Deoxy-D-manno-octulosonic-acid transferase
THITH_02420	ENOG4108ZI0	d,d-heptose 1,7-bisphosphate phosphatase
THITH_02425	ENOG4105F55	Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate (By similarity)
THITH_02430	ENOG4105DW0	Catalyzes the ADP transfer to D-glycero-D-manno-heptose 1-phosphate, yielding ADP-D,D-heptose (By similarity)
THITH_02435	ENOG4105CUI	Catalyzes the interconversion between ADP-D-glycero- beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose (By similarity)
THITH_02440	ENOG4108W7E	Catalyzes the ATP-dependent phosphorylation of the 3- deoxy-D-manno-octulosonic acid (Kdo) residue in Kdo-lipid IV(A) at the 4-OH position (By similarity)
THITH_02445	ENOG4105DKP	glycosyl transferase, family 9
THITH_02450	ENOG4105XA0	heptosyltransferase ii
THITH_02465	ENOG4105ZIE	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides (By similarity)
THITH_02470	ENOG4105VQ7	Rod shape-determining protein MreD
THITH_02475	ENOG4105N3I	Involved in formation and maintenance of cell shape (By similarity)
THITH_02480	ENOG4105DFF	Rod shape-determining protein mreb
THITH_02485	ENOG41080G2	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity)
THITH_02490	ENOG4105C3P	Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity)
THITH_02495	ENOG4105CHT	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity)
THITH_02500	ENOG4105F4C	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress (By similarity)
THITH_02505	ENOG4105HF0	Membrane
THITH_02510	ENOG4105CDM	Glutamate-1-semialdehyde aminotransferase
THITH_02515	ENOG4108UV6	Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity)
THITH_02520	ENOG4105DWF	phosphomethylpyrimidine kinase
THITH_02530	ENOG4105EJF	Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity)
THITH_02535	ENOG4108HRM	phosphoenolpyruvate--protein phosphotransferase
THITH_02540	ENOG4105C0N	N-acetylglutamate semialdehyde dehydrogenase
THITH_02545	ENOG4108YX9	iron--sulfur cluster insertion protein erpA
THITH_02550	ENOG4105ED7	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling (By similarity)
THITH_02555	ENOG4105DR5	peptidase
THITH_02560	ENOG4105DA0	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity)
THITH_02590	ENOG4105CY0	Metallo-Beta-Lactamase
THITH_02600	ENOG4105CDP	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity)
THITH_02610	ENOG4108YXY	alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
THITH_02615	ENOG4108IAB	Phoh family
THITH_02620	ENOG4105C2V	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity)
THITH_02625	ENOG4105CTB	Polyprenyl synthetase
THITH_02630	ENOG41067QG	Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity)
THITH_02635	ENOG4108RAC	Rubrerythrin
THITH_02655	ENOG4105DNJ	May play a role in the repair of endogenous alkylation damage (By similarity)
THITH_02660	ENOG4108JU6	CBS domain protein
THITH_02665	ENOG4106KVJ	cytochrome C assembly protein
THITH_02670	ENOG4105CB9	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
THITH_02675	ENOG4105K5M	30s ribosomal protein S16
THITH_02680	ENOG4108ZR6	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity)
THITH_02685	ENOG4105D6X	Specifically methylates guanosine-37 in various tRNAs (By similarity)
THITH_02690	ENOG4108YY1	This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity)
THITH_02700	ENOG4105QN4	diheme cytochrome
THITH_02705	ENOG4108XRS	Monoheme cytochrome SoxX (Sulfur oxidation)
THITH_02710	ENOG4105D6S	protein involved in catabolism of external DNA
THITH_02715	ENOG4105CJX	Molecular chaperone. Has ATPase activity (By similarity)
THITH_02725	ENOG4105ERU	peptidase
THITH_02730	ENOG4105DUM	transcriptional regulator, lysR family
THITH_02750	ENOG4105C03	ribonuclease
THITH_02765	ENOG4105D1U	peptidase U62 modulator of DNA gyrase
THITH_02770	ENOG4105CMS	peptidase U62, modulator of DNA gyrase
THITH_02780	ENOG4108V3E	phosphoribosylglycinamide formyltransferase
THITH_02785	ENOG4105CXB	phosphoribosylaminoimidazole synthetase
THITH_02790	ENOG4105BZQ	cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase
THITH_02795	ENOG4108KZ1	Mediates the interaction of DNA replication inititator protein DnaA with DNA polymerase subunit beta sliding clamp (dnaN). Stimulates hydrolysis of ATP-DnaA to ADP-DnaA, rendering DnaA inactive for reinititation, a process called regulatory inhibition of DnaA or RIDA (By similarity)
THITH_02805	ENOG4105CS1	NAD(P)H quinone oxidoreductase
THITH_02810	ENOG4105K89	arsenate reductase
THITH_02815	ENOG4105VSY	K01512 acylphosphatase EC 3.6.1.7
THITH_02820	ENOG4105C90	Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity)
THITH_02845	ENOG4105CQX	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity)
THITH_02850	ENOG4108JIC	nucleoside recognition domain protein
THITH_02855	ENOG4105E1F	short-chain dehydrogenase reductase
THITH_02875	ENOG4105C9M	aspartyl-trna synthetase
THITH_02885	ENOG4105CDY	transcriptional regulatory protein
THITH_02890	ENOG4105NHU	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group (By similarity)
THITH_02895	ENOG4105KA4	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity)
THITH_02900	ENOG4105CKJ	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity)
THITH_02905	ENOG4107YD3	Thioesterase
THITH_02910	ENOG4105E02	MotA TolQ exbB proton channel
THITH_02915	ENOG4105M8F	Biopolymer transport protein exbD tolR
THITH_02925	ENOG4107R6Y	Involved in the TonB-independent uptake of proteins (By similarity)
THITH_02930	ENOG4105KCK	Peptidoglycan-associated lipoprotein
THITH_02940	ENOG4107VRB	Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity)
THITH_02945	ENOG4105FD2	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity)
THITH_02985	ENOG4108YXQ	IS66 Orf2 family protein
THITH_03000	ENOG41085GJ	domain protein
THITH_03005	ENOG4108J2R	molybdopterin oxidoreductase
THITH_03010	ENOG4105QA4	4Fe-4S Ferredoxin, iron-sulfur binding domain protein
THITH_03050	ENOG4105CGB	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system (By similarity)
THITH_03055	ENOG4105E0C	molybdate abc transporter
THITH_03060	ENOG4108S6J	ABC transporter, periplasmic molybdate-binding protein
THITH_03165	ENOG4105D7D	AAA ATPase
THITH_03180	ENOG4105CP4	Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity)
THITH_03225	ENOG4105EE6	Alcohol dehydrogenase zinc-binding domain protein
THITH_03255	ENOG4105D3Z	quinone oxidoreductase, yhdh yhfp family
THITH_03260	ENOG4108RW0	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity)
THITH_03305	ENOG4105CJK	Catalyzes the dehydration of inosose (2-keto-myo- inositol, 2KMI or 2,4,6 3,5-pentahydroxycyclohexanone) to 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (D-2,3-diketo-4-deoxy-epi- inositol) (By similarity)
THITH_03350	ENOG4105K5B	UPF0225 protein
THITH_03365	ENOG4105EKQ	RNA-directed DNA polymerase
THITH_03380	ENOG4105VXP	Protein of unknown function DUF86
THITH_03430	ENOG4105CFI	type iii restriction protein res subunit
THITH_03500	ENOG4107QJR	hflk protein
THITH_03505	ENOG4105EPW	hflc protein
THITH_03515	ENOG4105C49	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine (By similarity)
THITH_03520	ENOG4105C91	Plays an important role in the de novo pathway of purine nucleotide biosynthesis
THITH_03530	ENOG4105C40	3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity)
THITH_03535	ENOG4105C2N	RNA methyltransferase TrmH family group 3
THITH_03540	ENOG4108ZDX	Binds together with S18 to 16S ribosomal RNA (By similarity)
THITH_03545	ENOG4105VH8	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity)
THITH_03555	ENOG4105K9Q	Binds to the 23S rRNA (By similarity)
THITH_03560	ENOG4105CDU	Replicative dna helicase
THITH_03565	ENOG4105CJ4	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity)
THITH_03570	ENOG4107RNS	bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase 3'-nucleotidase periplasmic
THITH_03575	ENOG4105ERG	peptidase m48, ste24p
THITH_03585	ENOG41082J7	Rhodanese domain protein
THITH_03590	ENOG41082K8	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Interacts with IscS and stimulates its activity. Then, accepts a sulfur from IscS and transfers it in turn to TusD (By similarity)
THITH_03595	ENOG4105PHD	The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity)
THITH_03600	ENOG4107ENK	receptor
THITH_03620	ENOG4105DF9	Lipoate-protein, ligase
THITH_03625	ENOG4105C7K	acetolactate synthase
THITH_03630	ENOG4108ZP8	Acetolactate synthase small subunit
THITH_03635	ENOG4105C6M	Alpha-keto-beta-hydroxylacyl reductoisomerase
THITH_03645	ENOG4106PT6	cdpdiacylglycerol-serine O-phosphatidyltransferase
THITH_03650	ENOG4105CYQ	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity)
THITH_03655	ENOG4108UN4	phage SPO1 DNA polymerase-related protein
THITH_03660	ENOG4105KEG	ribosomal-protein-alanine acetyltransferase
THITH_03750	ENOG4105C8A	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP (By similarity)
THITH_03765	ENOG4105N1F	Hnh endonuclease
THITH_03770	ENOG4108JJ7	ABC transporter
THITH_03775	ENOG4105C9U	ATP-dependent DNA helicase RecQ
THITH_03790	ENOG4107RVU	D-Ala-D-Ala carboxypeptidase 3 (S13) family
THITH_03805	ENOG4105CA4	amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity)
THITH_03810	ENOG4105MYG	DNA polymerase iii, chi subunit
THITH_03815	ENOG4105BZ6	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity)
THITH_03845	ENOG4105CQX	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity)
THITH_03850	ENOG4105C24	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
THITH_03855	ENOG4105D0M	Protease HtpX homolog
THITH_03860	ENOG4105C5X	domain protein
THITH_03865	ENOG4105BZU	Histidine kinase
THITH_03870	ENOG4105C1W	two component, sigma54 specific, transcriptional regulator, Fis family
THITH_03880	ENOG4108UM5	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity)
THITH_03885	ENOG4108UJD	30S ribosomal protein S9
THITH_03900	ENOG4105BZU	Histidine kinase
THITH_03910	ENOG4105C28	cystathionine
THITH_03915	ENOG4105ED9	Protein of unknown function (DUF455)
THITH_03920	ENOG4105F10	Catalyzes the hydrolysis of the pyrophosphate bond of UDP-2,3-diacylglucosamine to yield 2,3-diacylglucosamine 1- phosphate (lipid X) and UMP (By similarity)
THITH_03930	ENOG4105CN0	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity)
THITH_03955	ENOG4108RAV	Conserved protein
THITH_03975	ENOG4105CA0	peroxidase
THITH_03985	ENOG4105EKQ	RNA-directed DNA polymerase
THITH_04010	ENOG4105CI6	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving
THITH_04020	ENOG4105CA0	peroxidase
THITH_04025	ENOG4105C2R	Single-stranded-DNA-specific exonuclease (RecJ)
THITH_04030	ENOG4105D3R	alkyl hydroperoxide reductase
THITH_04050	ENOG4105CB8	Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity)
THITH_04060	ENOG4105WH1	Two component transcriptional regulator luxr family
THITH_04065	ENOG4105BZU	Histidine kinase
THITH_04070	ENOG4105CG0	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity)
THITH_04080	ENOG4107YB6	acetyltransferase, (GNAT) family
THITH_04085	ENOG4105CV9	cyclopropane-fatty-acyl-phospholipid synthase
THITH_04105	ENOG4105EUJ	GTP cyclohydrolase i
THITH_04120	ENOG4108JPZ	Monovalent cation H antiporter subunit D
THITH_04125	ENOG4108JPZ	Monovalent cation H antiporter subunit D
THITH_04135	ENOG4105D65	subunit l
THITH_04140	ENOG4105KJM	monovalent cation h antiporter subunit g
THITH_04175	ENOG4105CM0	Catalyzes the synthesis of GMP from XMP (By similarity)
THITH_04215	ENOG4108SHN	Glycosyl transferase, family 2
THITH_04250	ENOG4105DA6	Catalyzes the conversion of 5-methoxyuridine (mo5U) to uridine-5-oxyacetic acid (cmo5U) at position 34 in tRNA. May also participate in the methylation of uridine-5-oxyacetic acid (cmo5U) to uridine-5-oxyacetic acid methyl ester (mcmo5U) (By similarity)
THITH_04275	ENOG4105C1G	acyl-Coa dehydrogenase
THITH_04285	ENOG4105VEI	Removes the pyruvyl group from chorismate, with concomitant aromatization of the ring, to provide 4- hydroxybenzoate (4HB) for the ubiquinone pathway (By similarity)
THITH_04295	ENOG4105CEY	Amp-dependent synthetase and ligase
THITH_04320	ENOG4105CY2	Citrate transporter
THITH_04325	ENOG4105CVP	deoxyribo-dipyrimidine photolyase
THITH_04330	ENOG4108XDN	Transcriptional regulator
THITH_04355	ENOG4105CSM	endonuclease III
THITH_04360	ENOG4105DZB	Electron transport complex
THITH_04365	ENOG4108UQQ	Electron transport complex
THITH_04370	ENOG4105D6A	Electron transport complex
THITH_04380	ENOG4108R3D	Electron transport complex
THITH_04385	ENOG4105DGN	Electron transport complex
THITH_04390	ENOG4106YVY	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) (By similarity)
THITH_04395	ENOG4107QY0	Catalyzes the dehydration of methylthioribulose-1- phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1- phosphate (DK-MTP-1-P) (By similarity)
THITH_04400	ENOG4105CKH	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity)
THITH_04410	ENOG4105DHP	deoxycytidine triphosphate deaminase
THITH_04415	ENOG4108RKI	Necessary for the introduction of cis unsaturation into fatty acids. Catalyzes the dehydration of (3R)-3-hydroxydecanoyl- ACP to E-(2)-decenoyl-ACP and then its isomerization to Z-(3)- decenoyl-ACP. Can catalyze the dehydratase reaction for beta- hydroxyacyl-ACPs with saturated chain lengths up to 16 0, being most active on intermediate chain length (By similarity)
THITH_04430	ENOG4105D65	subunit l
THITH_04435	ENOG4105HC0	Na H antiporter
THITH_04440	ENOG4105MKQ	Monovalent cation H antiporter subunit C
THITH_04445	ENOG4108JPZ	Monovalent cation H antiporter subunit D
THITH_04450	ENOG4105SC1	monovalent cation H antiporter subunit E
THITH_04455	ENOG41080TA	Multiple resistance and ph regulation protein f
THITH_04460	ENOG4105KJM	monovalent cation h antiporter subunit g
THITH_04475	ENOG4108JQ7	(ABC) transporter
THITH_04480	ENOG4105C3U	ABC transporter
THITH_04505	ENOG4105BZG	amino acid carrier protein
THITH_04510	ENOG4105DXN	mazG family
THITH_04515	ENOG4105CJJ	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity)
THITH_04520	ENOG4105D18	nicotinate-nucleotide pyrophosphorylase
THITH_04530	ENOG4105BZH	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity)
THITH_04535	ENOG4105E05	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity)
THITH_04610	ENOG4108YXQ	IS66 Orf2 family protein
THITH_04620	ENOG41082AG	Plasmid maintenance system antidote protein
THITH_04700	ENOG4107S9F	NmrA family
THITH_04715	ENOG41083IP	HIT family
THITH_04725	ENOG4105CHR	reductase
THITH_04760	ENOG4107R6G	Catalyzes the S-adenosylmethionine monomethyl esterification of trans-aconitate (By similarity)
THITH_04770	ENOG4105E0F	Histidine kinase
THITH_04775	ENOG4105DPZ	Two component transcriptional regulator (Winged helix family
THITH_04790	ENOG4105BZU	Histidine kinase
THITH_04805	ENOG4105CV2	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates (By similarity)
THITH_04810	ENOG4105E26	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity)
THITH_04815	ENOG4108UM1	dedA family
THITH_04820	ENOG4108K5P	(LipO)protein
THITH_04825	ENOG4105DG1	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity)
THITH_04835	ENOG4105CHM	Aminotransferase
THITH_04840	ENOG4105D6E	homoserine dehydrogenase
THITH_04860	ENOG4105BZS	acriflavin resistance protein
THITH_04900	ENOG4108ZCA	Inherit from COG: pyridine nucleotide-disulfide oxidoreductase
THITH_04905	ENOG4105C0B	DNA polymerase III (alpha subunit)
THITH_04910	ENOG4105DXD	2-methylcitrate dehydratase
THITH_04920	ENOG4108RG3	short-chain dehydrogenase reductase
THITH_04930	ENOG4108R4Z	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine (By similarity)
THITH_04940	ENOG4105C3M	thioredoxin reductase
THITH_04945	ENOG4105CNU	cell division protein FtsK
THITH_04955	ENOG4105D1H	recombination factor protein RarA
THITH_04960	ENOG4108RSN	SNARE associated Golgi
THITH_04965	ENOG41061WM	D-Alanyl-D-Alanine
THITH_04985	ENOG4105VXP	Protein of unknown function DUF86
THITH_04995	ENOG4105KAV	tspo and mbr like protein
THITH_05015	ENOG4105CD5	CoA-binding domain protein
THITH_05035	ENOG410626R	Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity)
THITH_05040	ENOG4108T9Q	UPF0278 protein
THITH_05055	ENOG4107QK7	reductase
THITH_05060	ENOG4108SHN	Glycosyl transferase, family 2
THITH_05075	ENOG4105C5R	Aminotransferase
THITH_05090	ENOG4105WKW	Pfam:DUF1458
THITH_05105	ENOG4105C65	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity)
THITH_05110	ENOG4108Z11	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity)
THITH_05115	ENOG4105D1W	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity)
THITH_05125	ENOG4105C66	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity)
THITH_05130	ENOG4105C4E	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity)
THITH_05230	ENOG4105ED2	Beta-lactamase
THITH_05250	ENOG4105KJJ	Uncharacterized ACR, COG1993
THITH_05255	ENOG4105WMR	Protein CrcB homolog
THITH_05260	ENOG41084A1	Protein CrcB homolog
THITH_05310	ENOG4105CJW	magnesium transporter
THITH_05315	ENOG4105CJW	magnesium transporter
THITH_05320	ENOG4105CQU	Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity)
THITH_05340	ENOG4105CCD	The exact function is not known. Can catalyze the reduction of a variety of substrates like dimethyl sulfoxide, trimethylamine N-oxide, phenylmethyl sulfoxide and L-methionine sulfoxide. Cannot reduce cyclic N-oxides. Shows no activity as sulfite oxidase (By similarity)
THITH_05345	ENOG4105DQ2	Is probably involved in the electron transfer between its heme and the molybdenum cofactor of the reductase catalytic subunit YedY (By similarity)
THITH_05355	ENOG4108YZ4	nudix hydrolase
THITH_05395	ENOG4105D7T	ABC transporter
THITH_05400	ENOG4108IFG	nitrite reductase, (NAD(P)H)
THITH_05405	ENOG4105KH3	nitrite reductase (NAD(P)h) small subunit
THITH_05415	ENOG4105DW3	Response regulator receiver modulated metal dependent phosphohydrolase
THITH_05420	ENOG4105BZU	Histidine kinase
THITH_05430	ENOG4105D4F	Synthesizes selenophosphate from selenide and ATP (By similarity)
THITH_05435	ENOG41067HS	methyltransferase
THITH_05455	ENOG4105BZ1	(ABC) transporter
THITH_05470	ENOG4105BZU	Histidine kinase
THITH_05485	ENOG4105CNG	UPF0061 protein
THITH_05505	ENOG4108UPT	UPF0178 protein
THITH_05550	ENOG4107YJ4	chain length determinant protein
THITH_05570	ENOG4105ESV	Glycosyl transferase, family 4
THITH_05595	ENOG4105YXB	Toxic component of a toxin-antitoxin (TA) module. A
THITH_05680	ENOG4105CY0	Metallo-Beta-Lactamase
THITH_05700	ENOG4105VUH	addiction module killer protein
THITH_05725	ENOG4105PF0	Antitoxin component of a toxin-antitoxin (TA) module. Functions as an mRNA interferase antitoxin
THITH_05745	ENOG4107QQG	Dehydrogenase
THITH_05760	ENOG4105J5G	Transferase hexapeptide repeat containing protein
THITH_05770	ENOG4105CF4	DegT DnrJ EryC1 StrS aminotransferase
THITH_05775	ENOG4105C6V	Glycerol-3-phosphate dehydrogenase
THITH_05785	ENOG4105CCJ	Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity)
THITH_05805	ENOG4105EAG	UDP-N-acetylglucosamine 2-epimerase
THITH_05810	ENOG4107EF8	Glycosyl transferase (Group 1
THITH_05825	ENOG4107S90	membrAne
THITH_05850	ENOG4105WJ3	XRE family Transcriptional regulator
THITH_05865	ENOG4107S90	membrAne
THITH_05935	ENOG4107S90	membrAne
THITH_05965	ENOG4105C26	Dehydrogenase
THITH_06010	ENOG4107S90	membrAne
THITH_06020	ENOG4105CF4	DegT DnrJ EryC1 StrS aminotransferase
THITH_06070	ENOG4105E2N	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity)
THITH_06075	ENOG4105C6U	Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity)
THITH_06080	ENOG4105VIE	preprotein translocase, subunit YajC
THITH_06085	ENOG4107QN8	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity)
THITH_06090	ENOG4107RAB	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity)
THITH_06095	ENOG4105ECY	inositol monophosphatase
THITH_06100	ENOG4105CHG	glycolate oxidase (iron-sulfur subunit)
THITH_06105	ENOG4105VS7	Bifunctional enzyme which can phosphorylate or dephosphorylate isocitrate dehydrogenase (IDH) on a specific serine residue. This is a regulatory mechanism which enables bacteria to bypass the Krebs cycle via the glyoxylate shunt in response to the source of carbon. When bacteria are grown on glucose, IDH is fully active and unphosphorylated, but when grown on acetate or ethanol, the activity of IDH declines drastically concomitant with its phosphorylation (By similarity)
THITH_06110	ENOG4108I9X	Isocitrate lyase
THITH_06130	ENOG4105E46	N-alpha,N-alpha,N-alpha-trimethyl-L-histidine metabolic process
THITH_06135	ENOG4105C80	Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity)
THITH_06140	ENOG4107QP3	malate synthase g
THITH_06145	ENOG4105CHG	glycolate oxidase (iron-sulfur subunit)
THITH_06150	ENOG4105EU8	FAD linked oxidase domain protein
THITH_06155	ENOG4105CQB	FAD linked oxidase domain protein
THITH_06170	ENOG4105K3M	)-transporter
THITH_06205	ENOG4108V1U	phospholipid-binding protein
THITH_06220	ENOG4105C22	threonyL-tRNA synthetase
THITH_06225	ENOG4108UUX	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity)
THITH_06230	ENOG41082NX	50s ribosomal protein l35
THITH_06235	ENOG4108YZX	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity)
THITH_06240	ENOG4105CSS	phenylalanyl-tRNA synthetase (alpha subunit)
THITH_06245	ENOG4105C6A	phenylalanyl-tRNA synthetase (beta subunit)
THITH_06250	ENOG4108ZUF	This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity)
THITH_06265	ENOG4105DDT	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity)
THITH_06270	ENOG4105NWN	ApaG protein
THITH_06275	ENOG4105CHC	glucokinase (EC 2.7.1.2)
THITH_06280	ENOG4105D1X	Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity)
THITH_06285	ENOG4105CEZ	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) (By similarity)
THITH_06290	ENOG4105DBD	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation (By similarity)
THITH_06295	ENOG4105E7H	involved in the assembly of LPS in the outer leaflet of the outer membrane. Determines N-hexane tolerance and is involved in outer membrane permeability. Essential for envelope biogenesis (By similarity)
THITH_06300	ENOG4105F0N	pyrophosphate phospho-hydrolase
THITH_06310	ENOG4105CNI	cell division protein FtsW
THITH_06315	ENOG4105CVE	Lytic murein transglycosylase
THITH_06320	ENOG4105K6T	rare lipoprotein A
THITH_06325	ENOG4105DZ1	carboxypeptidase
THITH_06330	ENOG4105F0I	Aminotransferase
THITH_06335	ENOG4108Z43	UPF0250 protein
THITH_06345	ENOG4105C0G	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity)
THITH_06360	ENOG4108RW0	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity)
THITH_06380	ENOG4107S2Z	UPF0761 membrane protein
THITH_06390	ENOG4105CV9	cyclopropane-fatty-acyl-phospholipid synthase
THITH_06395	ENOG4106R49	Methyltransferase
THITH_06410	ENOG4105CY0	Metallo-Beta-Lactamase
THITH_06415	ENOG4105D4P	Coproporphyrinogen iii oxidase
THITH_06425	ENOG4105C58	cytochrome c oxidase accessory protein ccog
THITH_06430	ENOG4105D6P	C-type cytochrome. Part of the cbb3-type cytochrome c oxidase complex (By similarity)
THITH_06445	ENOG4105EUH	cytochrome C oxidase, cbb3-type, subunit i
THITH_06470	ENOG4108JA0	Oxidoreductase, FAD NAD(P)-binding domain protein
THITH_06495	ENOG4105M5K	heptosyltransferase
THITH_06510	ENOG4106WTF	Glycosyl transferase, family 2
THITH_06520	ENOG4107SBE	Glycosyl transferase (Group 1
THITH_06535	ENOG4107N1Q	ErfK YbiS YcfS YnhG family protein
THITH_06565	ENOG4105CGR	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity)
THITH_06580	ENOG4105M08	Membrane
THITH_06585	ENOG4108VPT	UPF0234 protein
THITH_06595	ENOG4108R5F	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity)
THITH_06600	ENOG4105EQR	Transposase IS116 IS110 IS902
THITH_06605	ENOG4105FFN	Specifically methylates the guanosine in position 1516 of 16S rRNA (By similarity)
THITH_06615	ENOG4105C5I	Dehydrogenase
THITH_06620	ENOG4108MN8	Membrane
THITH_06645	ENOG4105D44	asparaginase
THITH_06650	ENOG4105BZU	Histidine kinase
THITH_06700	ENOG4105E4C	Lytic transglycosylase catalytic
THITH_06705	ENOG4105HJX	Biotin- acetyl-CoA-carboxylase ligase
THITH_06710	ENOG4108194	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis (By similarity)
THITH_06735	ENOG4105CGD	Nad-dependent epimerase dehydratase
THITH_06750	ENOG4105DPX	Hydrogenase, large subunit
THITH_06755	ENOG4105CHG	glycolate oxidase (iron-sulfur subunit)
THITH_06765	ENOG4105E3S	small subunit
THITH_06775	ENOG4108USZ	hydrogenase
THITH_06800	ENOG4107RSS	Hydrogenase accessory protein HypB
THITH_06810	ENOG41083IP	HIT family
THITH_06835	ENOG4105WRB	Hydrogenase assembly chaperone hypC hupF
THITH_06845	ENOG4105C45	hydrogenase expression formation protein (HypE)
THITH_06860	ENOG4105CR7	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA (By similarity)
THITH_06880	ENOG4105KWW	Biogenesis protein
THITH_06885	ENOG4107QX9	Thiol disulfide interChange protein
THITH_06890	ENOG4105DA4	cytochrome c-type biogenesis protein
THITH_06895	ENOG4108ZKK	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH (By similarity)
THITH_06905	ENOG41060IM	Heme exporter protein
THITH_06910	ENOG4105CA5	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes (By similarity)
THITH_06915	ENOG4107EV4	once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system (By similarity)
THITH_06940	ENOG4105CJ3	phosphate transporter
THITH_06950	ENOG4105DDK	oxidoreductase, beta subunit
THITH_06955	ENOG4105D95	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin (By similarity)
THITH_06960	ENOG4105EJ5	oxidoreductase gamma subunit
THITH_06970	ENOG4105C9Y	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity)
THITH_06975	ENOG41062IR	nudix hydrolase
THITH_06980	ENOG4105BZU	Histidine kinase
THITH_06995	ENOG4105EAY	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
THITH_07010	ENOG4105DYT	3-hydroxyacyl-CoA dehydrogenase
THITH_07015	ENOG4105CHU	acetyl-coa acetyltransferase
THITH_07020	ENOG4107QPN	acyl-Coa dehydrogenase
THITH_07040	ENOG4105D0V	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity)
THITH_07050	ENOG4105CK5	oxidoreductase
THITH_07055	ENOG4108UH2	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity)
THITH_07060	ENOG4105C0B	DNA polymerase III (alpha subunit)
THITH_07065	ENOG4107QM9	Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (By similarity)
THITH_07070	ENOG4105D3U	Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity)
THITH_07075	ENOG4105C8D	Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity)
THITH_07080	ENOG4105CXR	Phospho-2-dehydro-3-deoxyoctonate aldolase
THITH_07085	ENOG4105C70	Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity)
THITH_07090	ENOG4105XX3	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic (By similarity)
THITH_07095	ENOG4105CE5	Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity)
THITH_07100	ENOG4105DF9	Lipoate-protein, ligase
THITH_07110	ENOG4108UH8	Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity)
THITH_07135	ENOG4105DS7	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity)
THITH_07150	ENOG4105C1A	potassium transporter peripheral membrane
THITH_07155	ENOG4105D37	Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA (By similarity)
THITH_07210	ENOG4105ESI	atpase involved in dna repair
THITH_07215	ENOG4105CB5	ATP-dependent DNA helicase recG
THITH_07225	ENOG4105CB5	ATP-dependent DNA helicase recG
THITH_07230	ENOG4105DZR	Type I site-specific deoxyribonuclease
THITH_07245	ENOG4105C1H	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity)
THITH_07250	ENOG4105CF3	3-Hydroxyisobutyrate dehydrogenase
THITH_07260	ENOG4105KUZ	arsenate reductase
THITH_07265	ENOG4105DMJ	Catalyzes the transfer of an acetyl group from acetyl- CoA to tetrahydrodipicolinate (By similarity)
THITH_07270	ENOG4105CHM	Aminotransferase
THITH_07280	ENOG4105KPV	Transcriptional regulator
THITH_07290	ENOG4105P9C	Participates in cysteine desulfuration mediated by SufS. Cysteine desulfuration mobilizes sulfur from L-cysteine to yield L-alanine and constitutes an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules. Functions as a sulfur acceptor for SufS, by mediating the direct transfer of the sulfur atom from the S-sulfanylcysteine of SufS, an intermediate product of cysteine desulfuration process (By similarity)
THITH_07295	ENOG4105C3K	feS assembly ATPase SufC
THITH_07305	ENOG4105VG1	fes assembly suf system protein
THITH_07315	ENOG4108Z4V	iron-sulfur cluster assembly
THITH_07320	ENOG4107QQG	Dehydrogenase
THITH_07325	ENOG4105CPH	Catalyzes the formation of S-adenosylmethionine from methionine and ATP
THITH_07335	ENOG4105C3T	may be the GTPase, regulating ATP sulfurylase activity (By similarity)
THITH_07360	ENOG4105DW3	Response regulator receiver modulated metal dependent phosphohydrolase
THITH_07365	ENOG4105D0M	Protease HtpX homolog
THITH_07370	ENOG4108YZY	peptidylprolyl cis-trans isomerase
THITH_07400	ENOG4105NBF	ammecr1 domain protein
THITH_07405	ENOG41074MP	UPF0103 Mediator of ErbB2-driven cell motility-containing protein
THITH_07415	ENOG4105F71	Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity)
THITH_07420	ENOG4105MRR	Transcriptional regulator (By similarity)
THITH_07430	ENOG4105C66	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity)
THITH_07445	ENOG4105CFT	Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import (By similarity)
THITH_07455	ENOG4108JJB	ABC transporter
THITH_07460	ENOG4107R37	Glutamate dehydrogenase
THITH_07475	ENOG4105C26	Dehydrogenase
THITH_07485	ENOG41063C6	UPF0235 protein
THITH_07505	ENOG4105GXZ	Ferredoxin-type protein NapH
THITH_07510	ENOG4108BGM	Quinol dehydrogenase periplasmic component
THITH_07515	ENOG4107QIW	Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity)
THITH_07530	ENOG4108JNI	Alpha beta hydrolase
THITH_07535	ENOG4108HMR	Key enzyme in the regulation of glycerol uptake and metabolism (By similarity)
THITH_07545	ENOG41080XP	Cbs domain
THITH_07550	ENOG4105E26	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity)
THITH_07590	ENOG4108IPX	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system (By similarity)
THITH_07595	ENOG4108ESU	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Involved in the translocation of the substrate across the membrane (By similarity)
THITH_07600	ENOG4105JKQ	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity)
THITH_07605	ENOG4105C20	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity)
THITH_07625	ENOG4105CX6	glutaminyL-tRNA synthetase
THITH_07630	ENOG4108ZXC	Two component transcriptional regulator, luxr family
THITH_07635	ENOG4105BZU	Histidine kinase
THITH_07655	ENOG4108UHJ	MAF-like protein
THITH_07660	ENOG4107QSA	Oxaloacetate decarboxylase
THITH_07665	ENOG4105CER	acetyl-CoA carboxylase biotin carboxylase
THITH_07675	ENOG4105VGS	50s ribosomal protein l32
THITH_07680	ENOG4105C6B	Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA (By similarity)
THITH_07685	ENOG4105CCZ	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity)
THITH_07690	ENOG41080ZE	Adenylate cyclase
THITH_07695	ENOG4105E50	uracil-dna glycosylase
THITH_07700	ENOG4105CII	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity)
THITH_07705	ENOG4105BZQ	cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase
THITH_07720	ENOG4105K64	Glycosyl transferase, family 2
THITH_07750	ENOG4105CSJ	Enoyl- acyl-carrier-protein reductase NADH
THITH_07775	ENOG4105K6V	RNA polymerase
THITH_07835	ENOG4108ETH	Formylglycinamide ribotide synthetase
THITH_07840	ENOG4105KJF	protein tyrosine phosphatase
THITH_07845	ENOG4105C03	ribonuclease
THITH_07850	ENOG4105CUX	Signal transduction histidine kinase
THITH_07855	ENOG4105BZU	Histidine kinase
THITH_07860	ENOG4105EI2	Pseudouridine synthase
THITH_07865	ENOG4108VXP	Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity)
THITH_07880	ENOG4108JA2	transcriptioN-repair coupling factor
THITH_07895	ENOG4105DWY	Agmatine deiminase
THITH_07905	ENOG4105D60	lipoprotein releasing system transmembrane protein
THITH_07910	ENOG4105CQU	Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity)
THITH_07920	ENOG4108EQH	DNA internalization-related competence protein ComEC Rec2
THITH_07925	ENOG4105C35	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity)
THITH_07930	ENOG4105C24	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
THITH_07935	ENOG4107QM1	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity)
THITH_07940	ENOG4108JQ1	Dehydrogenase
THITH_07945	ENOG4105CQC	Prephenate dehydratase
THITH_07950	ENOG4105CIH	Imidazole acetol-phosphate transaminase
THITH_07960	ENOG4105CMY	5-enolpyruvylshikimate-3-phosphate synthase
THITH_07965	ENOG4105CAT	Cytidine monophosphate kinase
THITH_07970	ENOG4105CAV	thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity)
THITH_07975	ENOG41080YA	This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity)
THITH_07980	ENOG4105CFV	Tetratricopeptide repeat protein
THITH_07985	ENOG4106EG9	Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) (By similarity)
THITH_07990	ENOG4105KQC	Competence protein
THITH_07995	ENOG4105C3Y	UTP-glucose-1-phosphate uridylyltransferase
THITH_08020	ENOG4105JNK	Glycosyl transferase (Group 1
THITH_08050	ENOG4105DH7	May be involved in recombination (By similarity)
THITH_08060	ENOG4107QYG	anthranilate phosphoribosyltransferase
THITH_08105	ENOG4106RZ4	Peptidase U32
THITH_08110	ENOG4105CFP	Peptidase U32
THITH_08150	ENOG4105CP4	Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity)
THITH_08165	ENOG4108Z0T	Part of a sulfur-relay system (By similarity)
THITH_08170	ENOG4105WH1	Two component transcriptional regulator luxr family
THITH_08175	ENOG4105BZU	Histidine kinase
THITH_08190	ENOG4105DQQ	Major facilitator superfamily MFS_1
THITH_08195	ENOG4105CRU	nitrate reductase, alpha subunit
THITH_08200	ENOG4108IUE	nitrate reductase beta subunit
THITH_08205	ENOG4105R3A	Nitrate reductase
THITH_08210	ENOG41076YT	nitrate reductase, gamma subunit
THITH_08360	ENOG4105KA0	thioesterase Superfamily protein
THITH_08365	ENOG4105CEY	Amp-dependent synthetase and ligase
THITH_08370	ENOG4105DNI	Converts SHCHC to OSB (By similarity)
THITH_08375	ENOG4108IPT	Naphthoate synthase
THITH_08385	ENOG4105C4A	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity)
THITH_08390	ENOG4105E4F	Isochorismate synthase
THITH_08405	ENOG4105GMT	ATPase associated with various cellular activities aaa_5
THITH_08410	ENOG4105DSQ	Nitric oxide reductase
THITH_08430	ENOG4108T0W	nitrous oxide maturation protein NosY
THITH_08435	ENOG4105CIG	ABC transporter
THITH_08460	ENOG4105DN3	alpha-2-macroglobulin domain protein
THITH_08465	ENOG4108JQB	penicillin-binding protein 1C
THITH_08505	ENOG4105D6C	Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity)
THITH_08570	ENOG4105JQN	Transcriptional regulator
THITH_08575	ENOG4105EUB	pirin domain protein
THITH_08580	ENOG4105CHJ	isochorismatase hydrolase
THITH_08605	ENOG4105CHM	Aminotransferase
THITH_08610	ENOG4105CCW	damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity)
THITH_08620	ENOG4107QPA	Cleaves GlcNAc linked beta-1,4 to MurNAc tripeptides (By similarity)
THITH_08635	ENOG4108UGV	hypoxanthine phosphoribosyltransferase
THITH_08640	ENOG4107RHB	Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S- adenosylmethionine. Has broad substrate specificity with 6- aminopurine nucleosides as preferred substrates (By similarity)
THITH_08650	ENOG4105T58	Dithiol-disulfide isomerase
THITH_08695	ENOG4105CK3	Lysine 2,3-aminomutase YodO family protein
THITH_08700	ENOG4105C9B	Cysteine desulfurase
THITH_08710	ENOG4107QRG	dna polymerase iii
THITH_08715	ENOG4108ZMD	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity)
THITH_08720	ENOG4105HHA	aminodeoxychorismate lyase
THITH_08735	ENOG4105C0Q	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity)
THITH_08740	ENOG4105VNB	Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity)
THITH_08745	ENOG4105CHR	reductase
THITH_08750	ENOG4105CJF	Malonyl coA-acyl carrier protein transacylase
THITH_08755	ENOG4105K9U	however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity)
THITH_08760	ENOG4105C2Z	ATP-dependent CLP protease ATP-binding subunit
THITH_08765	ENOG4105KAE	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation (By similarity)
THITH_08780	ENOG4105CCJ	Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity)
THITH_08785	ENOG41075W9	High frequency lysogenization protein HflD homolog
THITH_08790	ENOG4108I0Z	Aconitate hydratase
THITH_08805	ENOG4105CHQ	Murein-degrading enzyme that degrades murein glycan strands and insoluble, high-molecular weight murein sacculi, with the concomitant formation of a 1,6-anhydromuramoyl product. Lytic transglycosylases (LTs) play an integral role in the metabolism of the peptidoglycan (PG) sacculus. Their lytic action creates space within the PG sacculus to allow for its expansion as well as for the insertion of various structures such as secretion systems and flagella (By similarity)
THITH_08810	ENOG4105C9Q	fumarate hydratase class II
THITH_08815	ENOG4107QTF	adenylosuccinate lyase
THITH_08820	ENOG4105EZE	Cupin 4 family protein
THITH_08825	ENOG4105VGJ	Virulence-associated protein
THITH_08830	ENOG4105M0J	Toxic component of a toxin-antitoxin (TA) module. A
THITH_08865	ENOG4105C59	p-type ATPase
THITH_08880	ENOG4105C59	p-type ATPase
THITH_08915	ENOG4105XJC	Two component transcriptional regulator (Winged helix family
THITH_08920	ENOG4105IFJ	Histidine kinase
THITH_08925	ENOG4105CVB	Vitamin K epoxide reductase
THITH_08945	ENOG4105GR3	Histidine kinase
THITH_08970	ENOG4105BZU	Histidine kinase
THITH_08985	ENOG4107S7U	Sulfide dehydrogenase
THITH_09000	ENOG4105N7H	Cytochrome
THITH_09010	ENOG4105C1W	two component, sigma54 specific, transcriptional regulator, Fis family
THITH_09025	ENOG4105BZ6	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity)
THITH_09030	ENOG4105DA5	(ABC) transporter
THITH_09035	ENOG4105E3A	(ABC) transporter
THITH_09040	ENOG4105DR5	peptidase
THITH_09045	ENOG4105CWG	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34 (By similarity)
THITH_09050	ENOG4105CCT	upf0313 protein
THITH_09055	ENOG4105CBC	glutamate synthase
THITH_09060	ENOG4108S7T	Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP) (By similarity)
THITH_09085	ENOG4105D6T	Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity)
THITH_09090	ENOG4107RFD	Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity)
THITH_09095	ENOG4108VXP	Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity)
THITH_09100	ENOG4105CGY	Dna recombination protein
THITH_09115	ENOG4107S11	squalene-associated FAD-dependent desaturase
THITH_09120	ENOG4108ZXC	Two component transcriptional regulator, luxr family
THITH_09125	ENOG4105BZU	Histidine kinase
THITH_09135	ENOG4105UBK	short-chain dehydrogenase reductase
THITH_09155	ENOG4107QYT	Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor (By similarity)
THITH_09170	ENOG4105CZI	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
THITH_09180	ENOG4105C5H	ABC transporter
THITH_09190	ENOG4105VN1	Heat shock protein
THITH_09205	ENOG4105BZU	Histidine kinase
THITH_09235	ENOG41084EC	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease (By similarity)
THITH_09245	ENOG4105DYN	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. May be involved in the integration of spacer DNA into the CRISPR cassette (By similarity)
THITH_09250	ENOG41063ZP	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease (By similarity)
THITH_09320	ENOG41063ZP	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease (By similarity)
THITH_09345	ENOG4108W8W	CRISPR-associated RAMP protein, Csm3 family
THITH_09360	ENOG4105VM8	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding (By similarity)
THITH_09370	ENOG4105VM8	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding (By similarity)
THITH_09375	ENOG4105CFH	Aspartokinase
THITH_09380	ENOG4105CIM	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity)
THITH_09385	ENOG4105Y3E	Modulates RecA activity (By similarity)
THITH_09390	ENOG4105C68	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity)
THITH_09395	ENOG4105CEV	competence damage-inducible protein
THITH_09400	ENOG4105D86	that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity)
THITH_09405	ENOG4108Z4U	Ferredoxin
THITH_09415	ENOG4107QIX	Phosphoglucomutase (EC 5.4.2.2
THITH_09425	ENOG410681N	tpr repeat protein
THITH_09430	ENOG4105E33	succinate dehydrogenase
THITH_09440	ENOG4105N1I	succinate dehydrogenase, hydrophobic membrane anchor protein
THITH_09460	ENOG4105CEJ	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity)
THITH_09470	ENOG4105BZU	Histidine kinase
THITH_09480	ENOG4105CRK	lysyL-tRNA synthetase
THITH_09490	ENOG4105C26	Dehydrogenase
THITH_09495	ENOG4105C0C	Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity)
THITH_09530	ENOG4105FE9	pseudouridine synthase
THITH_09540	ENOG4105K8I	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity)
THITH_09545	ENOG4108KVX	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves (By similarity)
THITH_09550	ENOG4105C31	Tryptophanyl-tRNA synthetase
THITH_09560	ENOG4108Z4T	Peptidase M50
THITH_09565	ENOG4107RTD	sua5 ycio yrdc ywlc family protein
THITH_09570	ENOG4105K9H	YciI-like protein
THITH_09575	ENOG4107TF3	peptidylprolyl cis-trans isomerase
THITH_09580	ENOG4105C77	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity)
THITH_09585	ENOG4107NPY	receptor for the septal ring structure, may anchor it to the inner-membrane (By similarity)
THITH_09590	ENOG4105CDB	Required for chromosome condensation and partitioning (By similarity)
THITH_09595	ENOG4107YRI	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) (By similarity)
THITH_09600	ENOG4107S5T	Carbohydrate kinase
THITH_09610	ENOG4108HWB	Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity)
THITH_09620	ENOG4108VKV	Monofunctional biosynthetic peptidoglycan transglycosylase
THITH_09630	ENOG4105VJP	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell (By similarity)
THITH_09635	ENOG4107QMS	site-determining protein
THITH_09640	ENOG4105K7U	Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization (By similarity)
THITH_09655	ENOG4105BZU	Histidine kinase
THITH_09715	ENOG4105BZN	citrate synthase
THITH_09725	ENOG4108151	Beta-lactamase domain protein
THITH_09765	ENOG4107QR7	peptidase S8 and S53, subtilisin, kexin, sedolisin
THITH_09770	ENOG4105RX7	peptidase S8 and S53, subtilisin, kexin, sedolisin
THITH_09850	ENOG4107RFD	Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity)
THITH_09855	ENOG4105K64	Glycosyl transferase, family 2
THITH_09875	ENOG4108KQJ	Type 11 methyltransferase
THITH_09880	ENOG4105EY8	ABC transporter
THITH_09890	ENOG4107R5M	Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity)
THITH_09895	ENOG4108DMA	Nad-dependent epimerase dehydratase
THITH_09900	ENOG4105C0K	Gdp-mannose 4,6-dehydratase
THITH_09945	ENOG4105C3A	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs) (By similarity)
THITH_09950	ENOG4105DJ9	glucan biosynthesis protein
THITH_09975	ENOG4105C8P	)-transporter
THITH_09980	ENOG4105CK4	Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity)
THITH_09985	ENOG4105C8Y	Acetylornithine aminotransferase
THITH_09990	ENOG4105DBV	ornithine carbamoyltransferase
THITH_10000	ENOG4105C9X	ppx gppa phosphatase
THITH_10035	ENOG4105EY8	ABC transporter
THITH_10045	ENOG4107T8Q	Glycosyl transferase (Group 1
THITH_10055	ENOG4107SBB	4-alpha-glucanotransferase (EC 2.4.1.25)
THITH_10065	ENOG4107QQ4	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity)
THITH_10070	ENOG4105C9C	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity)
THITH_10085	ENOG4105BZ1	(ABC) transporter
THITH_10095	ENOG4105D3Q	Sugar transferase
THITH_10100	ENOG4108UHC	Glycosyl transferase, wecb taga cpsf family
THITH_10125	ENOG4105CPY	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity)
THITH_10135	ENOG4107R51	Glycosyl transferase, family 2
THITH_10160	ENOG4105GVR	general secretion pathway protein D
THITH_10200	ENOG4108VAU	general secretion pathway protein G
THITH_10205	ENOG4105D7Q	type ii secretion system
THITH_10210	ENOG4107QHF	type ii secretion system protein e
THITH_10215	ENOG4105C1B	dTDP-glucose 4-6-dehydratase
THITH_10225	ENOG4108URP	Dtdp-4-dehydrorhamnose 3,5-epimerase
THITH_10235	ENOG4106D4I	domain protein
THITH_10240	ENOG4107VRP	DNA repair exonuclease
THITH_10255	ENOG4105E9H	Lytic Murein transglycosylase
THITH_10260	ENOG4105DIT	ErfK YbiS YcfS YnhG family protein
THITH_10295	ENOG4107SGM	protein serine threonine phosphatase
THITH_10320	ENOG4105CNR	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
THITH_10325	ENOG4105C8S	subunit m
THITH_10330	ENOG4105D65	subunit l
THITH_10335	ENOG4105M5H	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
THITH_10345	ENOG4105P3U	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
THITH_10350	ENOG4105CMZ	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone (By similarity)
THITH_10355	ENOG4108IEH	NADH dehydrogenase subunit g
THITH_10370	ENOG4105CQV	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
THITH_10375	ENOG4105CYU	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
THITH_10380	ENOG4105ES3	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
THITH_10385	ENOG4105KWU	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
THITH_10400	ENOG4105DAF	Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity)
THITH_10405	ENOG4108YXN	Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity)
THITH_10410	ENOG4105D7M	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity)
THITH_10425	ENOG4105DZP	Membrane-associated zinc metalloprotease
THITH_10430	ENOG4105CEA	Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity)
THITH_10435	ENOG4105KNE	Phosphatidate cytidylyltransferase
THITH_10440	ENOG4105CR3	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity)
THITH_10445	ENOG4108VCV	Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity)
THITH_10450	ENOG4105C41	Catalyzes the reversible phosphorylation of UMP to UDP (By similarity)
THITH_10455	ENOG4105CU7	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity)
THITH_10465	ENOG4105CA1	Removes the N-terminal methionine from nascent proteins (By similarity)
THITH_10470	ENOG4105E1P	Modifies, by uridylylation or deuridylylation the PII (GlnB) regulatory protein (By similarity)
THITH_10480	ENOG4105CQ7	ATP-dependent helicase
THITH_10520	ENOG4108UJV	acyl-CoA thioesterase i
THITH_10525	ENOG4108I0Y	(ABC) transporter
THITH_10530	ENOG4105CV6	ABC transporter, permease
THITH_10535	ENOG4105CWR	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity)
THITH_10570	ENOG4108MIC	Mg-protoporphyrin IX methyl transferase
THITH_10595	ENOG4105E33	succinate dehydrogenase
THITH_10600	ENOG4105C00	Succinate dehydrogenase (Flavoprotein subunit)
THITH_10605	ENOG4108S24	Fumarate reduCtase
THITH_10620	ENOG4105IES	Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity)
THITH_10625	ENOG4105CKX	Catalyzes the conversion of 3'-phosphate to a 2',3'- cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps (A) adenylation of the enzyme by ATP
THITH_10645	ENOG4105D1N	poly(r)-hydroxyalkanoic acid synthase, class
THITH_10650	ENOG4108U4D	synthase) subunit
THITH_10660	ENOG4108NVM	synthesis repressor PhaR
THITH_10670	ENOG4105CHR	reductase
THITH_10675	ENOG4105CHQ	Murein-degrading enzyme that degrades murein glycan strands and insoluble, high-molecular weight murein sacculi, with the concomitant formation of a 1,6-anhydromuramoyl product. Lytic transglycosylases (LTs) play an integral role in the metabolism of the peptidoglycan (PG) sacculus. Their lytic action creates space within the PG sacculus to allow for its expansion as well as for the insertion of various structures such as secretion systems and flagella (By similarity)
THITH_10680	ENOG4108Z6B	deaminase
THITH_10690	ENOG4105DY2	Paraquat-inducible protein b
THITH_10695	ENOG4105DHJ	ABC, transporter
THITH_10700	ENOG4105CY3	ABC transporter, permease
THITH_10705	ENOG4105C7R	Atpase associated with various cellular activities aaa_3
THITH_10715	ENOG4105F8C	transglutaminase domain-containing protein
THITH_10720	ENOG4108ZF1	Transcriptional regulator, BadM Rrf2 family
THITH_10725	ENOG4107N1Q	ErfK YbiS YcfS YnhG family protein
THITH_10730	ENOG4105CBA	glutamine phosphoribosylpyrophosphate amidotransferase
THITH_10735	ENOG4105E96	Colicin v production protein
THITH_10745	ENOG4105DPM	folylpolyglutamate synthase Dihydrofolate synthase
THITH_10750	ENOG4107QTG	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA (By similarity)
THITH_10755	ENOG4105F6H	The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity)
THITH_10760	ENOG4105CG0	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity)
THITH_10770	ENOG4105DI7	Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity)
THITH_10785	ENOG4105CM3	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity)
THITH_10790	ENOG4105C0C	Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity)
THITH_10795	ENOG4105MQS	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity)
THITH_10800	ENOG4105CQI	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity)
THITH_10805	ENOG4105CYQ	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity)
THITH_10810	ENOG4105J0Q	Transcriptional regulator
THITH_10850	ENOG4105ENT	Efflux transporter rnd family, mfp subunit
THITH_10855	ENOG4105BZS	acriflavin resistance protein
THITH_10875	ENOG4105CNB	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity)
THITH_10880	ENOG4105EUB	pirin domain protein
THITH_10890	ENOG4105DRS	transport system, permease
THITH_10905	ENOG4108UVJ	appr-1-p processing domain protein
THITH_10910	ENOG4108RU0	short-chain dehydrogenase reductase
THITH_10925	ENOG4105DNZ	Alpha Beta Hydrolase
THITH_10940	ENOG4105D7A	ATP-binding protein
THITH_10955	ENOG4107QMW	pyridine nucleotide-disulfide oxidoreductase
THITH_10970	ENOG4105EKE	dihydroorotase
THITH_10975	ENOG4106RHG	Yeca family
THITH_11025	ENOG4105CI6	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving
THITH_11035	ENOG4107SCJ	type I restriction enzyme EcoKI subunit R
THITH_11040	ENOG4107R3N	Filamentation induced by cAMP protein fic
THITH_11050	ENOG4105KRQ	Addiction module toxin, Txe YoeB family
THITH_11060	ENOG4107XZC	Restriction modification system DNA (Specificity
THITH_11090	ENOG41084HI	prevent-host-death family
THITH_11110	ENOG4105M0J	Toxic component of a toxin-antitoxin (TA) module. A
THITH_11115	ENOG4105C4R	Atp-dependent dna helicase
THITH_11145	ENOG4107VBM	3-beta hydroxysteroid dehydrogenase isomerase
THITH_11200	ENOG4108YXQ	IS66 Orf2 family protein
THITH_11220	ENOG4105C3P	Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity)
THITH_11275	ENOG4105BZP	glycoside hydrolase 15-related
THITH_11290	ENOG4105CEY	Amp-dependent synthetase and ligase
THITH_11350	ENOG4105C7Z	Conserved Protein
THITH_11355	ENOG4105C3B	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity)
THITH_11360	ENOG4105C0V	Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity)
THITH_11365	ENOG4108YYV	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity)
THITH_11375	ENOG4105FAV	ABC, transporter
THITH_11380	ENOG4105FDK	ABC transporter
THITH_11390	ENOG41080IJ	Diacylglycerol kinase
THITH_11395	ENOG4105CBI	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
THITH_11400	ENOG4107QK8	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
THITH_11405	ENOG4105KE9	The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity)
THITH_11410	ENOG4105D43	The glycine cleavage system catalyzes the degradation of glycine (By similarity)
THITH_11415	ENOG4105EAK	ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family
THITH_11420	ENOG4105D0A	hydroxylase
THITH_11425	ENOG4107RAQ	aminopeptidase
THITH_11430	ENOG4105E07	UPF0149 protein
THITH_11440	ENOG4105W8B	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division (By similarity)
THITH_11445	ENOG4105MK2	5-formyltetrahydrofolate cyclo-ligase
THITH_11460	ENOG41065SU	Two-component system sensor kinase
THITH_11505	ENOG4105CVR	type I restriction-modification system
THITH_11515	ENOG4105C7B	Threonine dehydratase
THITH_11520	ENOG4105E66	phosphoriboisomerase A
THITH_11540	ENOG4105E18	UPF0276 protein
THITH_11555	ENOG4105CF7	AraC family transcriptional regulator
THITH_11570	ENOG4105DWR	Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity)
THITH_11610	ENOG4108Z9W	Outer membrane porin
THITH_11615	ENOG4108ZAI	phosphatidylglycerophosphatase a
THITH_11620	ENOG4105CG2	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity)
THITH_11625	ENOG4107YIM	Involved in the transcription termination process (By similarity)
THITH_11630	ENOG4108UTT	Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity)
THITH_11645	ENOG4105CA9	Pyruvate kinase
THITH_11655	ENOG4105BZF	Glycosyl transferase (Group 1
THITH_11665	ENOG4107QIW	Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity)
THITH_11670	ENOG4107QIW	Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity)
THITH_11675	ENOG4105QA4	4Fe-4S Ferredoxin, iron-sulfur binding domain protein
THITH_11680	ENOG4108MG3	formate dehydrogenase
THITH_11685	ENOG4105F46	Necessary for formate dehydrogenase activity (By similarity)
THITH_11725	ENOG4105EM7	Selenocysteine-specific translation elongation factor
THITH_11735	ENOG4108VA1	ABC transporter
THITH_11745	ENOG4105D4F	Synthesizes selenophosphate from selenide and ATP (By similarity)
THITH_11780	ENOG4105EUB	pirin domain protein
THITH_11790	ENOG4108UTW	Plays a role in the regulation of phosphate uptake
THITH_11795	ENOG4105BZY	Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity)
THITH_11800	ENOG4105E2Z	phosphate ABC transporter (Permease
THITH_11805	ENOG4105C8U	phosphate abc transporter
THITH_11820	ENOG4108V1T	peptidylprolyl cis-trans isomerase
THITH_11830	ENOG4105BZU	Histidine kinase
THITH_11835	ENOG4105CK6	Two component transcriptional regulator (Winged helix family
THITH_11840	ENOG4105DP0	ferredoxin-NADP reductase
THITH_11845	ENOG4105BZU	Histidine kinase
THITH_11850	ENOG4108Q6X	Aspartoacylase (EC 3.5.1.15)
THITH_11855	ENOG4105BZU	Histidine kinase
THITH_11860	ENOG4105K8F	Phosphoribosyl-amp cyclohydrolase
THITH_11865	ENOG4105C8N	cysteinyl-tRNA synthetase
THITH_11875	ENOG4105D7X	high-affinity nickel-transporter
THITH_11880	ENOG4108IQE	Amp-dependent synthetase and ligase
THITH_11885	ENOG4105CHM	Aminotransferase
THITH_11890	ENOG4105DKZ	GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity)
THITH_11895	ENOG4105CNE	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity)
THITH_11905	ENOG4105CUT	histidyl-tRNA synthetase
THITH_11920	ENOG4105C55	Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs
THITH_11925	ENOG4108UGX	Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity)
THITH_11930	ENOG4108ZF1	Transcriptional regulator, BadM Rrf2 family
THITH_11960	ENOG4108Z0T	Part of a sulfur-relay system (By similarity)
THITH_11980	ENOG4105CY1	sulfite reductase, dissimilatory-type alpha subunit
THITH_11985	ENOG4105PJW	Sulfite reductase dissimilatory-type beta subunit
THITH_11990	ENOG4108ZAT	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE (By similarity)
THITH_11995	ENOG4108ZKU	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions (By similarity)
THITH_12005	ENOG4108Z0T	Part of a sulfur-relay system (By similarity)
THITH_12030	ENOG4105QA4	4Fe-4S Ferredoxin, iron-sulfur binding domain protein
THITH_12040	ENOG4105C0Y	Responsible for the amidation of carboxylic groups at position A and C of either cobyrinic acid or hydrogenobrynic acid. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity)
THITH_12050	ENOG4107E2E	PKHD-type hydroxylase
THITH_12065	ENOG4105CET	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria (By similarity)
THITH_12070	ENOG4105W49	UPF0434 protein
THITH_12075	ENOG4105CHD	Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) (By similarity)
THITH_12085	ENOG4105BZ1	(ABC) transporter
THITH_12090	ENOG4109015	Biopolymer transport protein exbD tolR
THITH_12100	ENOG4105BZT	Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity)
THITH_12110	ENOG4105C6T	cysteine synthase
THITH_12115	ENOG4105KJV	Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity)
THITH_12120	ENOG4105CSZ	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate (By similarity)
THITH_12130	ENOG4105CWT	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity)
THITH_12145	ENOG4105C3F	Signal peptidase i
THITH_12150	ENOG4105C4S	Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity)
THITH_12160	ENOG4105C0H	protease
THITH_12175	ENOG41069E1	anti sigma-E protein RseA
THITH_12180	ENOG4105EMN	RNA polymerase sigma factor
THITH_12185	ENOG4108IYU	L-aspartate oxidase
THITH_12190	ENOG4108RBP	3'-to-5' exoribonuclease specific for small oligoribonucleotides (By similarity)
THITH_12200	ENOG41090A4	Pterin carbinolamine dehydratase
THITH_12205	ENOG4105E06	May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity)
THITH_12215	ENOG4107YU2	histidine triad (hIT) protein
THITH_12220	ENOG4105F3K	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity)
THITH_12225	ENOG4105KDX	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity)
THITH_12230	ENOG4107QMP	dna polymerase iii subunits gamma and tau
THITH_12230	ENOG4107QMP	dna polymerase iii subunits gamma and tau
THITH_12235	ENOG4105EHV	domain protein
THITH_12245	ENOG4106NZV	Responsible for synthesis of pseudouridine from uracil- 13 in transfer RNAs (By similarity)
THITH_12250	ENOG41072GX	Peptidase M22 Glycoprotease
THITH_12255	ENOG4105DVT	helicase
THITH_12265	ENOG4105BZ4	penicillin-binding protein
THITH_12280	ENOG4105K4H	Nlp p60 protein
THITH_12290	ENOG4108RIR	Molybdenum cofactor biosynthesis protein
THITH_12295	ENOG4105P9C	Participates in cysteine desulfuration mediated by SufS. Cysteine desulfuration mobilizes sulfur from L-cysteine to yield L-alanine and constitutes an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules. Functions as a sulfur acceptor for SufS, by mediating the direct transfer of the sulfur atom from the S-sulfanylcysteine of SufS, an intermediate product of cysteine desulfuration process (By similarity)
THITH_12305	ENOG4105DUM	transcriptional regulator, lysR family
THITH_12330	ENOG4105KNY	Microcompartments protein
THITH_12335	ENOG4105KNY	Microcompartments protein
THITH_12340	ENOG4105KNY	Microcompartments protein
THITH_12365	ENOG4108VFZ	ribulose bisphosphate carboxylase, small
THITH_12370	ENOG4105DT1	RuBisCO catalyzes two reactions the carboxylation of D- ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate
THITH_12380	ENOG4105NXH	GreA GreB family elongation factor
THITH_12390	ENOG4105BZU	Histidine kinase
THITH_12400	ENOG4106AXJ	AraC family transcriptional regulator
THITH_12410	ENOG4108VWS	Yaeq family
THITH_12425	ENOG4105DZ2	Transcriptional regulator
THITH_12430	ENOG4105DSS	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity)
THITH_12455	ENOG4105MQ2	17 kDa surface antigen
THITH_12470	ENOG4106YVY	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) (By similarity)
THITH_12510	ENOG4108JPV	Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity)
THITH_12525	ENOG4105BZU	Histidine kinase
THITH_12530	ENOG4107SKI	cobyrinic Acid a,c-diamide synthase
THITH_12540	ENOG4105CYN	Serine protein kinase
THITH_12545	ENOG4106AKX	UPF0229 protein
THITH_12550	ENOG4105ED1	spovr family
THITH_12605	ENOG4108V1T	peptidylprolyl cis-trans isomerase
THITH_12630	ENOG4105CVE	Lytic murein transglycosylase
THITH_12710	ENOG4105BZU	Histidine kinase
THITH_12715	ENOG4108Z6B	deaminase
THITH_12720	ENOG4106H3A	restriction
THITH_12765	ENOG4108UNV	SUF system FeS assembly protein, NifU family
THITH_12770	ENOG4105C9B	Cysteine desulfurase
THITH_12790	ENOG4105CM0	Catalyzes the synthesis of GMP from XMP (By similarity)
THITH_12795	ENOG4105CP4	Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity)
THITH_12800	ENOG4105DVS	Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity)
THITH_12805	ENOG4107S75	HAD-superfamily hydrolase subfamily IA variant 3
THITH_12810	ENOG4108V7X	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
THITH_12815	ENOG4106F3G	Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5- dihydroxy-2-cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon (By similarity)
THITH_12825	ENOG4108TQ9	Histidine kinase
THITH_12830	ENOG4105C1W	two component, sigma54 specific, transcriptional regulator, Fis family
THITH_12845	ENOG4107QN1	sodium solute
THITH_12860	ENOG4108IQF	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity)
THITH_12880	ENOG4107UX3	phosphatidylethanolamine N-methyltransferase
THITH_12885	ENOG4105C62	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity)
THITH_12890	ENOG4105K77	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity)
THITH_12895	ENOG4105D0T	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity)
THITH_12900	ENOG4105KG7	Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity)
THITH_12905	ENOG4107QHU	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity)
THITH_12910	ENOG4105CHV	Transcription elongation factor NusA
THITH_12925	ENOG4105CNR	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
THITH_12930	ENOG4105C8S	subunit m
THITH_12940	ENOG41080FQ	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
THITH_12945	ENOG4105DF2	NADH dehydrogenase subunit j
THITH_12950	ENOG41081XG	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
THITH_12955	ENOG4105CMZ	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone (By similarity)
THITH_12965	ENOG4107QIZ	NADH dehydrogenase
THITH_12975	ENOG4105CQV	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
THITH_12980	ENOG4105CYU	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
THITH_12985	ENOG4105ES3	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
THITH_12990	ENOG4105KWU	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
THITH_13000	ENOG4107EJC	Preprotein translocase subunit SecG
THITH_13005	ENOG4105CP7	Triose-phosphate isomerase
THITH_13010	ENOG4107QJF	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity)
THITH_13015	ENOG4105EEI	dihydropteroate synthase
THITH_13020	ENOG4105C3H	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity)
THITH_13025	ENOG4105F7M	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit (By similarity)
THITH_13030	ENOG4105HBR	Rna-binding protein
THITH_13035	ENOG4108UKH	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity)
THITH_13040	ENOG4105CU6	carbamoyl-phosphate synthetase ammonia chain
THITH_13045	ENOG4105C1M	carbamoyl-phosphate synthetase glutamine chain
THITH_13055	ENOG4105DUK	Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity)
THITH_13070	ENOG4105D10	5-enolpyruvylshikimate-3-phosphate phospholyase
THITH_13080	ENOG4105C76	Specifically methylates the 50S ribosomal protein L3 on a specific glutamine residue (By similarity)
THITH_13090	ENOG4105DJ4	phosphatidylserine decarboxylase
THITH_13095	ENOG4105CAP	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P (By similarity)
THITH_13100	ENOG4105DRH	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity)
THITH_13105	ENOG4105CK3	Lysine 2,3-aminomutase YodO family protein
THITH_13115	ENOG4105BZU	Histidine kinase
THITH_13120	ENOG4105BZ5	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity)
THITH_13125	ENOG4105CFG	Acts as a chaperone (By similarity)
THITH_13130	ENOG4105K90	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
THITH_13135	ENOG4105CI8	Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons (By similarity)
THITH_13140	ENOG4105F91	Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity)
THITH_13145	ENOG4105C4F	May be involved in recombinational repair of damaged DNA (By similarity)
THITH_13150	ENOG41090R7	Ferric uptake
THITH_13155	ENOG4105YRI	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity)
THITH_13160	ENOG4105VDB	UPF0125 protein
THITH_13165	ENOG4108Z1B	Cyclase dehydrase
THITH_13170	ENOG4105C8J	)-transporter
THITH_13175	ENOG4108UH4	Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity)
THITH_13180	ENOG4108JDX	DNA polymerase iii, epsilon subunit
THITH_13185	ENOG4108UMW	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity)
THITH_13205	ENOG4105CSJ	Enoyl- acyl-carrier-protein reductase NADH
THITH_13210	ENOG4107UUG	Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity)
THITH_13220	ENOG4105CEJ	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity)
THITH_13230	ENOG4105E26	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity)
THITH_13240	ENOG4105CA0	peroxidase
THITH_13250	ENOG4105SG9	biopolymer transport protein, ExbD
THITH_13255	ENOG4105E02	MotA TolQ exbB proton channel
THITH_13260	ENOG4105WQ5	TonB family
THITH_13275	ENOG4105CHI	Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB (By similarity)
THITH_13285	ENOG4107S7U	Sulfide dehydrogenase
THITH_13295	ENOG4105C1W	two component, sigma54 specific, transcriptional regulator, Fis family
THITH_13300	ENOG4108TQ9	Histidine kinase
THITH_13315	ENOG4108EE5	Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity)
THITH_13320	ENOG4105D6C	Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity)
THITH_13325	ENOG4105CQU	Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity)
THITH_13330	ENOG4108EE5	Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity)
THITH_13345	ENOG4108PNC	copper resistance
THITH_13350	ENOG4105WKS	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity)
THITH_13355	ENOG41081FY	multiple antibiotic resistance (MarC)-related
THITH_13385	ENOG4105EKQ	RNA-directed DNA polymerase
THITH_13415	ENOG4105K70	DNA-binding protein
THITH_13420	ENOG4105C6P	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity)
THITH_13425	ENOG4105CHN	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity)
THITH_13435	ENOG4105CCQ	Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity)
THITH_13440	ENOG4105DEA	Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation
THITH_13450	ENOG4105C1N	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity)
THITH_13455	ENOG4105KW8	RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity)
THITH_13460	ENOG4105DKX	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity)
THITH_13465	ENOG4105DC6	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity)
THITH_13470	ENOG4105C5C	n-acetylmuramoyl-l-alanine amidase
THITH_13475	ENOG4105K8N	protein family UPF0079, ATPase
THITH_13480	ENOG4105DR1	Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity)
THITH_13485	ENOG4105EH2	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity)
THITH_13490	ENOG4105C7D	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
THITH_13495	ENOG4105K63	Thioredoxin
THITH_13500	ENOG4105T95	Thiol disulfide interChange protein
THITH_13505	ENOG4105C13	Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity)
THITH_13510	ENOG4107QX8	SPFH domain, Band 7 family protein
THITH_13520	ENOG4105FNP	Molybdopterin-guanine dinucleotide biosynthesis protein b
THITH_13525	ENOG4105CVM	Molybdenum cofactor synthesis domain protein
THITH_13550	ENOG4105D6C	Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity)
THITH_13565	ENOG4108YZN	class I peptide chain release factor
THITH_13580	ENOG4108UJV	acyl-CoA thioesterase i
THITH_13585	ENOG4105C94	Transporter
THITH_13600	ENOG4107QP8	phosphohexose isomerase
THITH_13605	ENOG4105CXW	Synthesizes alpha-1,4-glucan chains using ADP-glucose (By similarity)
THITH_13610	ENOG4105CCA	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle (By similarity)
THITH_13615	ENOG4108Z2X	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine (By similarity)
THITH_13620	ENOG4108IAA	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity)
THITH_13625	ENOG4105CCG	Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity)
THITH_13635	ENOG4105K8U	2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
THITH_13640	ENOG4105DJ0	Poly(A) Polymerase
THITH_13650	ENOG4105VEJ	Heat shock protein
THITH_13655	ENOG4108TGY	Glutathione S-transferase
THITH_13660	ENOG4108ZZ3	UPF0260 protein
THITH_13680	ENOG4105C7Q	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity)
THITH_13685	ENOG4105D8W	glucose-6-phosphate 1-dehydrogenase
THITH_13715	ENOG41066DG	(EAL) domain protein
THITH_13720	ENOG4105CAE	Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity)
THITH_13735	ENOG4107TAE	Glycosyl transferase (Group 1
THITH_13740	ENOG4105C0D	helicase
THITH_13745	ENOG4105WJ3	XRE family Transcriptional regulator
THITH_13815	ENOG4106A5H	cytochrome c554
THITH_13820	ENOG4105DS0	Transcriptional regulator, Crp Fnr family
THITH_13835	ENOG4105N42	UPF0307 protein
THITH_13855	ENOG4106A3M	Cytochrome p-450
THITH_13865	ENOG4105CEY	Amp-dependent synthetase and ligase
THITH_13880	ENOG4105BZM	domain protein
THITH_13905	ENOG4105BZU	Histidine kinase
THITH_13920	ENOG4105M8F	Biopolymer transport protein exbD tolR
THITH_13930	ENOG4105WQ5	TonB family
THITH_13935	ENOG4108UQY	Iron-storage protein
THITH_13940	ENOG4105C4M	(Ubiquinol oxidase) subunit I
THITH_13945	ENOG4105CFY	cytochrome d ubiquinol oxidase, subunit ii
THITH_13950	ENOG4108JJ9	ABC, transporter
THITH_13955	ENOG4108JJ8	(ABC) transporter
THITH_13965	ENOG4105BZU	Histidine kinase
THITH_13970	ENOG4105C2Z	ATP-dependent CLP protease ATP-binding subunit
THITH_13975	ENOG4105DBW	Multi-copper polyphenol oxidoreductase laccase
THITH_13980	ENOG4105C34	Pseudouridine synthase
THITH_13985	ENOG4106SNF	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
THITH_13990	ENOG4108YZA	Nitrogen regulatory protein pii
THITH_13995	ENOG4105C4K	Nad synthetase
THITH_14000	ENOG4105CH8	Succinyl-CoA ligase ADP-forming subunit alpha
THITH_14005	ENOG4105CMV	Succinyl-CoA synthetase subunit beta
THITH_14015	ENOG4107TUY	Histidine kinase
THITH_14020	ENOG4105C1W	two component, sigma54 specific, transcriptional regulator, Fis family
THITH_14025	ENOG4108Z03	MAF-like protein
THITH_14030	ENOG4108UXA	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity)
THITH_14040	ENOG4108Z1W	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity)
THITH_14045	ENOG4105C2S	Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity)
THITH_14060	ENOG4105C8T	Leucyl-tRNA synthetase
THITH_14065	ENOG4105C6V	Glycerol-3-phosphate dehydrogenase
THITH_14105	ENOG4105CQU	Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity)
THITH_14120	ENOG4105CE8	Transfers the fatty acyl group on membrane lipoproteins (By similarity)
THITH_14125	ENOG4108JU5	Magnesium and cobalt efflux protein
THITH_14130	ENOG4105KGE	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity)
THITH_14135	ENOG4105C9A	Phoh family
THITH_14140	ENOG4105CIW	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity)
THITH_14145	ENOG4108UUM	single-stranded DNA-binding protein
THITH_14150	ENOG4107RDB	Major Facilitator
THITH_14155	ENOG4105C5U	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity)
THITH_14160	ENOG4108ZT0	50S ribosomal protein l17
THITH_14165	ENOG4105CTF	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
THITH_14170	ENOG4105G6W	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity)
THITH_14175	ENOG4108UHH	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity)
THITH_14180	ENOG4108Z04	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
THITH_14185	ENOG41067V7	50S ribosomal protein L36
THITH_14190	ENOG4105CGG	The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity)
THITH_14195	ENOG4108UZ0	Binds to the 23S rRNA (By similarity)
THITH_14200	ENOG4105VPB	50S ribosomal protein L30
THITH_14205	ENOG4108RA9	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity)
THITH_14210	ENOG4105K4C	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity)
THITH_14215	ENOG4108R5J	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity)
THITH_14220	ENOG4108UJY	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity)
THITH_14225	ENOG4105VBI	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity)
THITH_14230	ENOG4105CW6	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
THITH_14235	ENOG4105KAR	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity)
THITH_14240	ENOG4108UNN	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity)
THITH_14245	ENOG4105K87	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal
THITH_14255	ENOG4108R70	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity)
THITH_14260	ENOG4105CKE	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity)
THITH_14265	ENOG4105KAP	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity)
THITH_14270	ENOG4105K7S	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity)
THITH_14275	ENOG4105CFD	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
THITH_14280	ENOG41080KG	One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity)
THITH_14285	ENOG4106U5A	One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity)
THITH_14290	ENOG4105EEE	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity)
THITH_14295	ENOG4108Z10	Involved in the binding of tRNA to the ribosomes (By similarity)
THITH_14300	ENOG4105CGV	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity)
THITH_14305	ENOG4105CEJ	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity)
THITH_14310	ENOG4108UHY	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity)
THITH_14315	ENOG4108UKE	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity)
THITH_14320	ENOG4105D27	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
THITH_14325	ENOG4108IIJ	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
THITH_14330	ENOG4105KBC	Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity)
THITH_14335	ENOG4108VZM	50s ribosomal protein L10
THITH_14340	ENOG4105C64	Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity)
THITH_14345	ENOG4108UIK	This protein binds directly to 23S ribosomal RNA (By similarity)
THITH_14350	ENOG4105E5V	Participates in transcription elongation, termination and antitermination (By similarity)
THITH_14355	ENOG4105PM1	preprotein translocase subunit SecE
THITH_14365	ENOG4105CGV	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity)
THITH_14385	ENOG4107QHF	type ii secretion system protein e
THITH_14400	ENOG4108ZQD	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity)
THITH_14405	ENOG4105DHA	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity (By similarity)
THITH_14410	ENOG4105M6F	mutator MutT protein
THITH_14415	ENOG4105C5V	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity)
THITH_14420	ENOG4105CI6	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving
THITH_14430	ENOG4105C7C	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity)
THITH_14435	ENOG4105CDK	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity)
THITH_14440	ENOG4105CIT	This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity)
THITH_14445	ENOG4105K7E	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly (By similarity)
THITH_14450	ENOG4105CPF	Cell wall formation (By similarity)
THITH_14455	ENOG4105D4A	Cell wall formation (By similarity)
THITH_14460	ENOG4105DFU	Cell wall formation (By similarity)
THITH_14465	ENOG4105DVQ	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity)
THITH_14470	ENOG4105CNI	cell division protein FtsW
THITH_14475	ENOG4105DMZ	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity)
THITH_14480	ENOG4105CPY	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity)
THITH_14485	ENOG4108EQQ	Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein (By similarity)
THITH_14490	ENOG4107EEN	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity)
THITH_14495	ENOG4105CJN	penicillin-binding protein
THITH_14500	ENOG41063Y6	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic (By similarity)
THITH_14505	ENOG4105CGJ	Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity)
THITH_14510	ENOG4108V6E	Cell division protein mraZ
THITH_14520	ENOG4105CU0	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity)
THITH_14525	ENOG4105E1C	Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1A (PBP1a) (By similarity)
THITH_14530	ENOG41082RQ	UPF0102 protein
THITH_14535	ENOG4105CQB	FAD linked oxidase domain protein
THITH_14540	ENOG4105KB2	stringent starvation protein b
THITH_14545	ENOG4107MKT	Stringent starvation protein a
THITH_14550	ENOG4105EIX	cytochrome c1
THITH_14555	ENOG4105DJ5	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity)
THITH_14560	ENOG4108R5F	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity)
THITH_14565	ENOG4107QNR	UPF0135 protein
THITH_14570	ENOG4105C0H	protease
THITH_14575	ENOG4105CIH	Imidazole acetol-phosphate transaminase
THITH_14580	ENOG4105CEK	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity)
THITH_14585	ENOG4105E99	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity)
THITH_14590	ENOG4105E21	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity)
THITH_14595	ENOG4105CDF	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity)
THITH_14610	ENOG4107PE3	Mammalian cell entry related domain protein
THITH_14615	ENOG4105CY3	ABC transporter, permease
THITH_14620	ENOG4105DHJ	ABC, transporter
THITH_14635	ENOG4105C2X	Arabinose 5-phosphate isomerase
THITH_14640	ENOG4108Z4R	3-deoxy-d-manno-octulosonate 8-phosphate phosphatase
THITH_14655	ENOG4108IUZ	ABC transporter
THITH_14660	ENOG4105DTW	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity)
THITH_14665	ENOG41080QH	sigma 54 modulation protein ribosomal protein S30EA
THITH_14670	ENOG4107RM2	PTS IIA-like nitrogen-regulatory protein PtsN
THITH_14675	ENOG4105D1C	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion (By similarity)
THITH_14680	ENOG4105C21	Displays ATPase and GTPase activities (By similarity)
THITH_14705	ENOG41080RH	Thioredoxin
THITH_14715	ENOG4108UMA	3-octaprenyl-4-hydroxybenzoate carboxy-lyase
THITH_14720	ENOG4105DFU	Cell wall formation (By similarity)
THITH_14730	ENOG410903C	(LipO)protein
THITH_14735	ENOG4105CDH	Citrulline--aspartate ligase
THITH_14740	ENOG4107QN2	dihydrolipoyl dehydrogenase
THITH_14745	ENOG4107QSN	dihydrolipoamide acetyltransferase
THITH_14750	ENOG4105DAQ	Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity)
THITH_14755	ENOG4105DH5	Responsible for the end-turnover of tRNA specifically removes the terminal AMP residue from uncharged tRNA (tRNA-C-C-A). Also appears to be involved in tRNA biosynthesis (By similarity)
THITH_14760	ENOG4105M2J	Glutaredoxin
THITH_14765	ENOG4105C3G	gtp-binding protein
THITH_14770	ENOG4108ZPD	The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity)
THITH_14775	ENOG4105KW6	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity)
THITH_14780	ENOG4105C5T	Phosphoribosyl pyrophosphate synthase
THITH_14790	ENOG4105CTR	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity)
THITH_14800	ENOG4105DJQ	tetratricopeptide tpr_2 repeat protein
THITH_14805	ENOG4105C7E	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity)
THITH_14810	ENOG4105C8K	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity)
THITH_14825	ENOG4105D06	uba thif-type nad fad binding protein
THITH_14830	ENOG4105CD8	aminopeptidase N
THITH_14835	ENOG4105F8V	Hydrolase, tatD family
THITH_14840	ENOG4105M85	Bola protein
THITH_14865	ENOG4105KHV	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity)
THITH_14875	ENOG4105E4G	Type IV pilus
THITH_14900	ENOG4108JQC	penicillin-binding protein 1A
THITH_14910	ENOG4105CFZ	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity)
THITH_14920	ENOG4105VCC	30S ribosomal protein S21
THITH_14925	ENOG4105D49	3-dehydroquinate synthase
THITH_14930	ENOG4105C4Q	deoxyguanosinetriphosphate triphosphohydrolase-like protein
THITH_14940	ENOG4105E0A	ABC, transporter
THITH_14945	ENOG4105EHG	Permease protein
THITH_14950	ENOG4105JKQ	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity)
THITH_14955	ENOG4108374	Joins Ado-cobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin) (By similarity)
THITH_14970	ENOG4108YZT	Adenosylcobinamide kinase
THITH_14980	ENOG4105EFT	decarboxylase
THITH_14985	ENOG4105DH2	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group (By similarity)
THITH_14990	ENOG41068B1	Cob-I-yrinic acid a,c-diamide adenosyltransferase
THITH_14995	ENOG4105CHI	Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB (By similarity)
THITH_15000	ENOG4105C9G	DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity)
THITH_15005	ENOG4105DG1	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity)
THITH_15065	ENOG4105VUH	addiction module killer protein
THITH_15070	ENOG4105YES	addiction module antidote protein
THITH_15140	ENOG41067CV	Integrase
THITH_15175	ENOG4105BZU	Histidine kinase
THITH_15185	ENOG4105CM2	brancheD-chain amino acid aminotransferase
THITH_15190	ENOG4105CE6	Adenylation and deadenylation of glutamate--ammonia ligase (By similarity)
THITH_15200	ENOG4107QVT	Binding-protein-dependent transport systems, inner membrane component
THITH_15205	ENOG4105C53	Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity)
THITH_15210	ENOG4105CFU	surface antigen
THITH_15215	ENOG4105MA0	exported protein
THITH_15230	ENOG4105D6C	Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity)
THITH_15240	ENOG4108IFH	alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
THITH_15260	ENOG4105C1W	two component, sigma54 specific, transcriptional regulator, Fis family
THITH_15270	ENOG4105CJ9	Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity)
THITH_15275	ENOG4105K5Y	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity)
THITH_15300	ENOG4105VF7	tolerance protein
THITH_15305	ENOG4105CSG	Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps (By similarity)
THITH_15310	ENOG4107QX9	Thiol disulfide interChange protein
THITH_15315	ENOG4108Z38	Catalyzes a trans-dehydration via an enolate intermediate (By similarity)
THITH_15320	ENOG4105KM4	Acetyl-CoA carboxylase, biotin carboxyl carrier protein
THITH_15325	ENOG4105CER	acetyl-CoA carboxylase biotin carboxylase
THITH_15330	ENOG4105F59	Methylates ribosomal protein L11 (By similarity)
THITH_15340	ENOG4105CEH	Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity)
THITH_15385	ENOG4108V1T	peptidylprolyl cis-trans isomerase
THITH_15390	ENOG4105C01	Dihydroxy-acid dehydratase
THITH_15405	ENOG4105EGS	Mechanosensitive ion channel
THITH_15410	ENOG4107R11	Transcriptional regulator
THITH_15420	ENOG4107QZM	n-acetylglutamate synthase
THITH_15430	ENOG4108WUH	Transcriptional regulator, TetR family
THITH_15450	ENOG4108YXQ	IS66 Orf2 family protein
THITH_15465	ENOG4105EUB	pirin domain protein
THITH_15505	ENOG4108YZA	Nitrogen regulatory protein pii
THITH_15515	ENOG4105K8U	2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
THITH_15520	ENOG4107ZVW	dihydroneopterin aldolase
THITH_15535	ENOG4107QXP	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity)
THITH_15555	ENOG4105C1A	potassium transporter peripheral membrane
THITH_15560	ENOG4105C1W	two component, sigma54 specific, transcriptional regulator, Fis family
THITH_15565	ENOG4105ES5	Histidine kinase
THITH_15575	ENOG4105CYJ	ribosomal RNA small subunit methyltransferase B
THITH_15580	ENOG4105CAE	Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity)
THITH_15585	ENOG4108Z02	Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity)
THITH_15595	ENOG4105C79	DNA protecting protein DprA
THITH_15600	ENOG4108RPN	Protein smg homolog
THITH_15610	ENOG4105EK0	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity)
THITH_15615	ENOG4105DBS	Key enzyme in heme biosynthesis. Catalyzes the oxidative decarboxylation of propionic acid side chains of rings A and B of coproporphyrinogen III (By similarity)
THITH_15620	ENOG4105D52	delta-aminolevulinic acid dehydratase
THITH_15625	ENOG4105E2X	shikimate dehydrogenase
THITH_15630	ENOG4108ZG0	Ompa motb domain protein
THITH_15635	ENOG4105C4G	Synthesis of 3-octaprenyl-4-hydroxybenzoate (By similarity)
THITH_15640	ENOG4105MJ2	Competence protein
THITH_15650	ENOG4105CZF	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity)
THITH_15655	ENOG4107EEK	Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity)
THITH_15660	ENOG4108ZCA	Inherit from COG: pyridine nucleotide-disulfide oxidoreductase
THITH_15665	ENOG4105C0A	alcohol dehydrogenase
THITH_15670	ENOG4105W5Q	DNA repair protein (RadC
THITH_15675	ENOG4105CJS	Phosphopantothenoylcysteine decarboxylase
THITH_15685	ENOG4105CAS	nag kinase
THITH_15730	ENOG4105VNG	YcgL domain-containing protein
THITH_15735	ENOG4105DP5	Catalyzes the biosynthesis of agmatine from arginine (By similarity)
THITH_15740	ENOG4105CCX	Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity)
THITH_15745	ENOG4108V7X	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
THITH_15750	ENOG41070EG	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes (By similarity)
THITH_15755	ENOG4105EHM	Aminoglycoside phosphotransferase
THITH_15760	ENOG4108S0S	Nucleotidyl transferase
THITH_15775	ENOG4105EMN	RNA polymerase sigma factor
THITH_15795	ENOG4105CIZ	coA-substrate-specific enzyme activase
THITH_15810	ENOG4108Z7F	N-acetyltransferase
THITH_15830	ENOG4108S0N	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol (By similarity)
THITH_15835	ENOG4105FDS	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity)
THITH_15840	ENOG4108UKZ	OsmC family
THITH_15845	ENOG4107RYR	Transcriptional regulator, Crp Fnr family
THITH_15850	ENOG4105DK0	Indole-3-glycerol phosphate synthase
THITH_15855	ENOG4108I0Q	anthranilate phosphoribosyltransferase
THITH_15860	ENOG4105DDQ	anthranilate synthase
THITH_15865	ENOG4108ZF1	Transcriptional regulator, BadM Rrf2 family
THITH_15875	ENOG4105CRQ	synthase (Component I)
THITH_15880	ENOG4108VXP	Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity)
THITH_15900	ENOG4107Y49	methyltransferase
THITH_15905	ENOG4105CY8	phosphoribosylaminoimidazole carboxylase atpase subunit
THITH_15910	ENOG4108UM6	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity)
THITH_15915	ENOG4105C8V	SAICAR synthetase
THITH_15920	ENOG4105E78	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity)
THITH_15930	ENOG4105D2N	Aldolase
THITH_15935	ENOG4105CA9	Pyruvate kinase
THITH_15940	ENOG4105BZA	Phosphoglycerate kinase
THITH_15945	ENOG4105C17	glyceraldehyde-3-phosphate dehydrogenase
THITH_15950	ENOG4105CV1	Transketolase (EC 2.2.1.1)
THITH_15955	ENOG4105CPH	Catalyzes the formation of S-adenosylmethionine from methionine and ATP
THITH_15960	ENOG4105C3E	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine (By similarity)
THITH_15965	ENOG4105SYT	Methylenetetrahydrofolate reductase
THITH_15970	ENOG4105QF0	Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity)
THITH_15980	ENOG4105D7Z	glutathione synthase
THITH_15985	ENOG41081YB	ApbE family
THITH_16000	ENOG4105WQ5	TonB family
THITH_16005	ENOG4108UJU	UPF0301 protein
THITH_16020	ENOG4105CXT	aspartate transcarbamylase
THITH_16025	ENOG4105CD3	dihydroorotase
THITH_16030	ENOG4105CZX	twitching motility protein
THITH_16035	ENOG4105CZX	twitching motility protein
THITH_16040	ENOG4105CZX	twitching motility protein
THITH_16045	ENOG4105DFA	alanine racemase domain protein
THITH_16050	ENOG4105II7	pyrroline-5-carboxylate reductase
THITH_16055	ENOG4108VIA	integral membrane protein
THITH_16075	ENOG4107Y3D	HAD-superfamily hydrolase subfamily IA variant 3
THITH_16085	ENOG4107RK2	ADP-ribose diphosphatase NudE
THITH_16090	ENOG4108RNI	3'(2')5'-bisphosphate nucleotidase
THITH_16115	ENOG4107STW	synthase
THITH_16120	ENOG4105E0X	reductase
THITH_16125	ENOG4105BZS	acriflavin resistance protein
THITH_16130	ENOG4105ENT	Efflux transporter rnd family, mfp subunit
THITH_16135	ENOG4105D9M	gamma-glutamylcysteine synthetase
THITH_16145	ENOG4105WH1	Two component transcriptional regulator luxr family
THITH_16150	ENOG4105BZU	Histidine kinase
THITH_16160	ENOG4107QX9	Thiol disulfide interChange protein
THITH_16165	ENOG4105DA4	cytochrome c-type biogenesis protein
THITH_16170	ENOG4108ZKK	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH (By similarity)
THITH_16190	ENOG4105KWW	Biogenesis protein
THITH_16195	ENOG4107QX9	Thiol disulfide interChange protein
THITH_16200	ENOG4105DA4	cytochrome c-type biogenesis protein
THITH_16215	ENOG4107S7U	Sulfide dehydrogenase
THITH_16220	ENOG4105DHT	Metal Dependent Phosphohydrolase
THITH_16225	ENOG4105C5H	ABC transporter
THITH_16250	ENOG4105ECY	inositol monophosphatase
THITH_16255	ENOG4105F8J	Adenylate Guanylate cyclase
THITH_16290	ENOG4105DGM	nitrilase cyanide hydratase and apolipoprotein n-acyltransferase
THITH_16295	ENOG4105IJJ	transcriptional regulator, crp fnr family
THITH_16310	ENOG4105C3R	Methionine synthase
THITH_16315	ENOG4105DWA	May conjugate Arg from its aminoacyl-tRNA to the N- termini of proteins containing an N-terminal aspartate or glutamate
THITH_16320	ENOG4105CPH	Catalyzes the formation of S-adenosylmethionine from methionine and ATP
THITH_16335	ENOG4105DC1	bifunctional purine biosynthesis protein purh
THITH_16340	ENOG4105C12	Phosphoribosylglycinamide synthetase
THITH_16345	ENOG4107QQN	Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity)
THITH_16350	ENOG4105CBM	Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 (By similarity)
THITH_16355	ENOG4105VFB	Binds the 23S rRNA (By similarity)
THITH_16365	ENOG4105C6K	Malic enzyme
THITH_16370	ENOG4105C80	Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity)
THITH_16390	ENOG4107SC1	transglycosylase
THITH_16405	ENOG4105VXR	cytoplasmic protein
THITH_16415	ENOG4105WH1	Two component transcriptional regulator luxr family
THITH_16435	ENOG4106H78	methyltransferase
THITH_16450	ENOG4105CCP	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC)
THITH_16455	ENOG4105CAK	Cell division ATP-binding protein ftsE
THITH_16465	ENOG4105DEK	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity)
THITH_16475	ENOG4107QI6	Cysteine desulfurase
THITH_16495	ENOG4105C59	p-type ATPase
THITH_16505	ENOG4105C58	cytochrome c oxidase accessory protein ccog
THITH_16510	ENOG4105D6P	C-type cytochrome. Part of the cbb3-type cytochrome c oxidase complex (By similarity)
THITH_16525	ENOG4105EUH	cytochrome C oxidase, cbb3-type, subunit i
THITH_16530	ENOG4106T9E	Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity)
THITH_16535	ENOG4105D3C	The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity)
THITH_16540	ENOG4105K7Z	Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity)
THITH_16545	ENOG4105CPM	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity)
THITH_16555	ENOG4105CHR	reductase
THITH_16560	ENOG4105W0Z	cytoplasmic protein
THITH_16565	ENOG4105C0P	Mg chelatase subunit ChlI
THITH_16605	ENOG41082J7	Rhodanese domain protein
THITH_16620	ENOG41082AG	Plasmid maintenance system antidote protein
THITH_16660	ENOG4105C3H	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity)
THITH_16670	ENOG4105CHP	RNA polymerase
THITH_16690	ENOG4105GRZ	Ycii-related protein
THITH_16715	ENOG4107S21	permease
THITH_16725	ENOG4105C3J	Cysteine desulfurase
THITH_16730	ENOG4105D3S	4Fe-4S Ferredoxin, iron-sulfur binding domain protein
THITH_16745	ENOG4105C17	glyceraldehyde-3-phosphate dehydrogenase
THITH_16750	ENOG4105W87	Cbs domain
THITH_16755	ENOG4107R5R	arsenical pump membrane protein
THITH_16765	ENOG4105VXN	addiction module toxin, RelE StbE family
THITH_16810	ENOG4105CQU	Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity)
THITH_16845	ENOG4105BZU	Histidine kinase
THITH_16850	ENOG4105C1X	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity (By similarity)
THITH_16865	ENOG4105DW3	Response regulator receiver modulated metal dependent phosphohydrolase
THITH_16870	ENOG4105BZU	Histidine kinase
THITH_16905	ENOG4105BZU	Histidine kinase
THITH_16925	ENOG4108UHA	Essential for recycling GMP and indirectly, cGMP (By similarity)
THITH_16930	ENOG4105VFG	Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity)
THITH_16935	ENOG4105CWR	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity)
THITH_16940	ENOG4105KME	endoribonuclease L-psp
THITH_16945	ENOG4105CB5	ATP-dependent DNA helicase recG
THITH_16955	ENOG4105CB3	Required for the thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32) (By similarity)
THITH_16960	ENOG4107RE5	NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity)
THITH_16965	ENOG4105D28	Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity)
THITH_16970	ENOG4107QJE	Chromosome Partitioning Protein
THITH_16975	ENOG4105FA0	parb-like partition protein
THITH_16985	ENOG4107RAZ	it plays a direct role in the translocation of protons across the membrane (By similarity)
THITH_16990	ENOG4105KY6	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity)
THITH_16995	ENOG4107Z6K	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity)
THITH_17000	ENOG4107S15	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity)
THITH_17005	ENOG4105CDG	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity)
THITH_17010	ENOG4105J80	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity)
THITH_17015	ENOG4105C4J	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity)
THITH_17020	ENOG4105KNM	Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity)
THITH_17025	ENOG4105CAJ	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity)
THITH_17030	ENOG4105C46	Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity)
THITH_17040	ENOG4108UUC	Protein of unknown function DUF99
THITH_17045	ENOG4105C0H	protease
THITH_17055	ENOG4106N16	had-superfamily hydrolase, subfamily iib
THITH_17060	ENOG4107S0N	DJ-1 family
THITH_17065	ENOG4105CN1	protease
THITH_17070	ENOG41063SB	peptidase
THITH_17075	ENOG41080HT	Transcriptional regulator, arsr family
THITH_17080	ENOG4107YZP	Rhodanese domain protein
THITH_17085	ENOG4105VW4	glutaredoxin 3
THITH_17095	ENOG4105IX2	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA (By similarity)
THITH_17100	ENOG4105CSF	NADPH-dependent glycerol-3-phosphate dehydrogenase
THITH_17105	ENOG4108UIQ	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity)
THITH_17110	ENOG4105C1W	two component, sigma54 specific, transcriptional regulator, Fis family
THITH_17115	ENOG4105CUX	Signal transduction histidine kinase
THITH_17135	ENOG4105C2M	dna polymerase I
THITH_17145	ENOG4108ZX6	Electron transport protein SCO1 SenC
THITH_17155	ENOG4105WHM	Necessary for normal cell division and for the maintenance of normal septation (By similarity)
THITH_17165	ENOG4108Z33	Thiol disulfide Interchange Protein
THITH_17185	ENOG4105DRC	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity)
THITH_17190	ENOG4105BZU	Histidine kinase
THITH_17195	ENOG4105WH1	Two component transcriptional regulator luxr family
THITH_17200	ENOG4105WH1	Two component transcriptional regulator luxr family
THITH_17205	ENOG4105BZU	Histidine kinase
THITH_17230	ENOG4105CAQ	asparagine synthetase
THITH_17235	ENOG4105CXT	aspartate transcarbamylase
THITH_17240	ENOG4106XMA	In vivo, quickly hydrolyzes the ureidoacrylate peracid to avoid toxicity, but can also hydrolyzes ureidoacrylate that is formed spontaneously from ureidoacrylate peracid. One of the products of hydrolysis, carbamate, hydrolyzes spontaneously, thereby releasing one of the pyrimidine rings nitrogen atoms as ammonia and one of its carbons as CO2 (By similarity)
THITH_17250	ENOG41067TZ	transcriptional regulator, MarR family
THITH_17260	ENOG4105C94	Transporter
THITH_17280	ENOG4105CGK	Exodeoxyribonuclease III
THITH_17285	ENOG4107QP2	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity)
THITH_17290	ENOG4105CBF	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity)
THITH_17310	ENOG4105C5I	Dehydrogenase
THITH_17315	ENOG4105C1J	atp-dependent rna helicase
THITH_17320	ENOG4105CZI	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
THITH_17325	ENOG4105CTQ	phosphohexokinase
THITH_17340	ENOG4108ZEF	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity)
THITH_17345	ENOG4105K5D	4fe-4S ferredoxin iroN-sulfur binding
THITH_17350	ENOG4105CFB	Gamma-glutamyltranspeptidase (EC 2.3.2.2)
THITH_17375	ENOG4106PT6	cdpdiacylglycerol-serine O-phosphatidyltransferase
THITH_17385	ENOG4105C7S	Dehydrogenase
THITH_17390	ENOG4105C7P	2-oxoglutarate dehydrogenase, E1
THITH_17395	ENOG4105C4R	Atp-dependent dna helicase
THITH_17420	ENOG4107S7U	Sulfide dehydrogenase
THITH_17445	ENOG4108YYA	Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity)
THITH_17450	ENOG4106C6A	Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity)
THITH_17455	ENOG4108JIP	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit (By similarity)
THITH_17460	ENOG4108JIQ	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit (By similarity)
THITH_17465	ENOG4105K4G	Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity)
THITH_17500	ENOG4105DHW	Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins
THITH_17505	ENOG4105VAS	Could be involved in insertion of integral membrane proteins into the membrane (By similarity)
THITH_17510	ENOG4105NVJ	RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity)