locus-tag	class	description
THITH_00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
THITH_00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
THITH_00020	COG0187	DNA topoisomerase II activity
THITH_00025	COG1704	LemA family
THITH_00035	COG0339	signal peptide processing
THITH_00040	COG0708	Exodeoxyribonuclease III
THITH_00050	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
THITH_00060	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
THITH_00060	COG0543	2 iron, 2 sulfur cluster binding
THITH_00070	COG0181	hydroxymethylbilane synthase activity
THITH_00075	COG0165	Argininosuccinate lyase
THITH_00145	COG3031	protein transport across the cell outer membrane
THITH_00150	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
THITH_00155	COG2197	response regulator
THITH_00170	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
THITH_00175	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
THITH_00180	COG4636	protein conserved in cyanobacteria
THITH_00210	COG1132	(ABC) transporter
THITH_00230	COG1132	(ABC) transporter
THITH_00250	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
THITH_00255	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
THITH_00280	COG1598	PFAM Uncharacterised protein family UPF0150
THITH_00360	COG0463	Glycosyl transferase, family 2
THITH_00375	COG4969	Belongs to the N-Me-Phe pilin family
THITH_00385	COG4636	protein conserved in cyanobacteria
THITH_00400	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
THITH_00400	COG2111	Na H antiporter
THITH_00420	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
THITH_00450	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
THITH_00455	COG0140	phosphoribosyl-ATP diphosphatase activity
THITH_00460	COG0107	imidazoleglycerol-phosphate synthase activity
THITH_00465	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
THITH_00470	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
THITH_00475	COG0131	Imidazoleglycerol-phosphate dehydratase
THITH_00505	COG4106	trans-aconitate 2-methyltransferase activity
THITH_00510	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
THITH_00520	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
THITH_00525	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
THITH_00530	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
THITH_00540	COG2226	methyltransferase
THITH_00550	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
THITH_00560	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
THITH_00560	COG2111	Na H antiporter
THITH_00565	COG0651	ATP synthesis coupled electron transport
THITH_00570	COG0651	ATP synthesis coupled electron transport
THITH_00575	COG1006	Multisubunit Na H antiporter MnhC subunit
THITH_00590	COG1320	monovalent cation:proton antiporter activity
THITH_00610	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
THITH_00620	COG0267	Belongs to the bacterial ribosomal protein bL33 family
THITH_00625	COG0227	Belongs to the bacterial ribosomal protein bL28 family
THITH_00630	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
THITH_00645	COG2274	protein secretion by the type I secretion system
THITH_00650	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
THITH_00655	COG2197	response regulator
THITH_00705	COG3706	GGDEF domain
THITH_00715	COG2010	Cytochrome c
THITH_00725	COG1404	Belongs to the peptidase S8 family
THITH_00735	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
THITH_00740	COG1074	ATP-dependent DNA helicase activity
THITH_00745	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
THITH_00755	COG2226	methyltransferase
THITH_00770	COG0247	lactate metabolic process
THITH_00775	COG1139	Iron-sulfur cluster binding protein
THITH_00780	COG1556	Lactate utilization protein
THITH_00785	COG1620	l-lactate permease
THITH_00790	COG2226	methyltransferase
THITH_00800	COG1595	DNA-templated transcription, initiation
THITH_00820	COG1111	helicase
THITH_00820	COG1205	dead DEAH box helicase
THITH_00910	COG0142	geranyltranstransferase activity
THITH_00915	COG0261	This protein binds to 23S rRNA in the presence of protein L20
THITH_00920	COG0211	Belongs to the bacterial ribosomal protein bL27 family
THITH_00925	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
THITH_00930	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
THITH_00935	COG0268	Binds directly to 16S ribosomal RNA
THITH_00945	COG0728	peptidoglycan biosynthetic process
THITH_00950	COG0196	riboflavin kinase activity
THITH_00955	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
THITH_00960	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
THITH_00965	COG1047	Peptidyl-prolyl cis-trans
THITH_00970	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
THITH_00975	COG0523	cobalamin synthesis protein
THITH_00995	COG0784	Response regulator, receiver
THITH_00995	COG2205	protein histidine kinase activity
THITH_01005	COG0601	transmembrane transport
THITH_01010	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
THITH_01035	COG0737	Belongs to the 5'-nucleotidase family
THITH_01045	COG3077	Addiction module antitoxin, RelB DinJ family
THITH_01050	COG3041	Addiction module toxin RelE StbE family
THITH_01060	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
THITH_01100	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
THITH_01145	COG3177	Filamentation induced by cAMP protein fic
THITH_01155	COG1205	dead DEAH box helicase
THITH_01155	COG1111	helicase
THITH_01170	COG0735	belongs to the Fur family
THITH_01185	COG2022	thiamine diphosphate biosynthetic process
THITH_01190	COG0220	tRNA (guanine-N7-)-methyltransferase activity
THITH_01195	COG0589	response to stress
THITH_01200	COG3273	potassium ion transport
THITH_01200	COG0471	metal ion transport
THITH_01205	COG3954	Phosphoribulokinase
THITH_01220	COG0667	Aldo Keto reductase
THITH_01235	COG0084	hydrolase, TatD family'
THITH_01240	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
THITH_01250	COG0751	glycine-tRNA ligase activity
THITH_01255	COG0752	glycyl-tRNA synthetase alpha subunit
THITH_01265	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
THITH_01270	COG0174	glutamine synthetase
THITH_01275	COG1278	Cold shock
THITH_01280	COG1444	tRNA N-acetyltransferase activity
THITH_01295	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
THITH_01310	COG1538	Outer membrane efflux protein
THITH_01315	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
THITH_01320	COG1309	transcriptional regulator
THITH_01325	COG0617	tRNA 3'-terminal CCA addition
THITH_01335	COG1012	belongs to the aldehyde dehydrogenase family
THITH_01345	COG0205	6-phosphofructokinase activity
THITH_01350	COG0563	adenylate kinase activity
THITH_01370	COG3302	dmso reductase anchor subunit
THITH_01375	COG0437	4 iron, 4 sulfur cluster binding
THITH_01380	COG0243	molybdopterin cofactor binding
THITH_01400	COG2046	Belongs to the sulfate adenylyltransferase family
THITH_01425	COG1047	Peptidyl-prolyl cis-trans
THITH_01440	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
THITH_01455	COG0635	Involved in the biosynthesis of porphyrin-containing compound
THITH_01460	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
THITH_01465	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
THITH_01470	COG1561	YicC-like family, N-terminal region
THITH_01485	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
THITH_01495	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
THITH_01500	COG0315	cyclic pyranopterin monophosphate synthase activity
THITH_01515	COG1194	a g-specific adenine glycosylase
THITH_01520	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
THITH_01530	COG0582	viral genome integration into host DNA
THITH_01535	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
THITH_01625	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
THITH_01680	COG0523	cobalamin synthesis protein
THITH_01715	COG1067	ATP-dependent peptidase activity
THITH_01725	COG0121	glutamine amidotransferase
THITH_01730	COG0235	Class ii aldolase
THITH_01735	COG5002	protein histidine kinase activity
THITH_01735	COG5001	Diguanylate cyclase
THITH_01770	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
THITH_01770	COG1372	Participates in initiation and elongation during chromosome replication
THITH_01785	COG4772	TonB-dependent receptor
THITH_01795	COG0735	belongs to the Fur family
THITH_01805	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
THITH_01820	COG0523	cobalamin synthesis protein
THITH_01840	COG1121	(ABC) transporter
THITH_01850	COG0326	Molecular chaperone. Has ATPase activity
THITH_01885	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
THITH_01930	COG3093	addiction module antidote protein HigA
THITH_01970	COG1643	Atp-dependent helicase
THITH_01980	COG0018	arginyl-trna synthetase
THITH_01985	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
THITH_01990	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
THITH_01995	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
THITH_02000	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
THITH_02010	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
THITH_02015	COG1058	Belongs to the CinA family
THITH_02015	COG1546	Belongs to the CinA family
THITH_02035	COG0463	Glycosyl transferase, family 2
THITH_02040	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
THITH_02060	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
THITH_02070	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
THITH_02080	COG0746	molybdenum cofactor guanylyltransferase activity
THITH_02085	COG0303	'Molybdopterin
THITH_02095	COG2864	formate dehydrogenase
THITH_02105	COG0437	4 iron, 4 sulfur cluster binding
THITH_02110	COG3383	formate dehydrogenase (NAD+) activity
THITH_02140	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
THITH_02150	COG2133	pyrroloquinoline quinone binding
THITH_02170	COG3744	PilT protein domain protein
THITH_02180	COG3077	Addiction module antitoxin, RelB DinJ family
THITH_02185	COG1396	sequence-specific DNA binding
THITH_02210	COG1487	ribonuclease activity
THITH_02290	COG0745	RESPONSE REGULATOR receiver
THITH_02290	COG2972	Histidine kinase
THITH_02300	COG2337	Toxic component of a toxin-antitoxin (TA) module
THITH_02305	COG1262	PFAM Formylglycine-generating sulfatase enzyme
THITH_02310	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
THITH_02315	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
THITH_02355	COG0446	pyridine nucleotide-disulphide oxidoreductase
THITH_02375	COG0745	RESPONSE REGULATOR receiver
THITH_02380	COG5000	phosphorelay sensor kinase activity
THITH_02405	COG4067	protein conserved in archaea
THITH_02405	COG0189	ligase activity
THITH_02410	COG1560	Kdo2-lipid A biosynthetic process
THITH_02415	COG1519	Transferase
THITH_02420	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
THITH_02425	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
THITH_02430	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
THITH_02430	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
THITH_02435	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
THITH_02440	COG3642	lipopolysaccharide core region biosynthetic process
THITH_02445	COG0859	PFAM glycosyl transferase family 9
THITH_02450	COG0859	PFAM glycosyl transferase family 9
THITH_02465	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
THITH_02470	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
THITH_02475	COG1792	Involved in formation and maintenance of cell shape
THITH_02480	COG1077	Cell shape determining protein MreB Mrl
THITH_02485	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
THITH_02490	COG0154	amidase activity
THITH_02495	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
THITH_02500	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
THITH_02505	COG0730	response to heat
THITH_02510	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
THITH_02515	COG0352	thiamine-phosphate diphosphorylase activity
THITH_02520	COG0351	phosphomethylpyrimidine kinase
THITH_02520	COG0352	thiamine-phosphate diphosphorylase activity
THITH_02530	COG0494	nUDIX hydrolase
THITH_02540	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
THITH_02545	COG0316	Belongs to the HesB IscA family
THITH_02555	COG0739	heme binding
THITH_02560	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
THITH_02590	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
THITH_02600	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
THITH_02610	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
THITH_02615	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
THITH_02620	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
THITH_02625	COG0142	geranyltranstransferase activity
THITH_02635	COG1592	Rubrerythrin
THITH_02660	COG4536	flavin adenine dinucleotide binding
THITH_02665	COG4137	Cytochrome C assembly protein
THITH_02670	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
THITH_02675	COG0228	four-way junction DNA binding
THITH_02680	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
THITH_02685	COG0336	Belongs to the RNA methyltransferase TrmD family
THITH_02690	COG0335	large ribosomal subunit rRNA binding
THITH_02700	COG3258	Cytochrome c
THITH_02705	COG2010	Cytochrome c
THITH_02710	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
THITH_02715	COG0326	Molecular chaperone. Has ATPase activity
THITH_02725	COG0616	signal peptide processing
THITH_02750	COG1530	ribonuclease E activity
THITH_02760	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
THITH_02765	COG0312	modulator of DNA gyrase
THITH_02770	COG0312	modulator of DNA gyrase
THITH_02780	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
THITH_02785	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
THITH_02790	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
THITH_02795	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
THITH_02810	COG1393	Belongs to the ArsC family
THITH_02815	COG1254	Belongs to the acylphosphatase family
THITH_02820	COG0442	prolyl-tRNA aminoacylation
THITH_02845	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
THITH_02850	COG2715	membrane protein required for spore maturation
THITH_02855	COG0300	oxidoreductase activity
THITH_02875	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
THITH_02885	COG0217	transcriptional regulatory protein
THITH_02890	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
THITH_02895	COG0632	four-way junction helicase activity
THITH_02900	COG2255	four-way junction helicase activity
THITH_02905	COG0824	Thioesterase
THITH_02925	COG0823	Involved in the tonB-independent uptake of proteins
THITH_02940	COG0602	queuosine metabolic process
THITH_02945	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
THITH_02980	COG4372	Transposase
THITH_02985	COG3436	PFAM IS66 Orf2 family protein
THITH_03000	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
THITH_03010	COG0437	4 iron, 4 sulfur cluster binding
THITH_03050	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
THITH_03165	COG1222	aaa ATPase
THITH_03255	COG0604	alcohol dehydrogenase
THITH_03260	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
THITH_03285	COG0811	peptide transport
THITH_03305	COG1082	Xylose isomerase domain protein TIM barrel
THITH_03350	COG3012	SEC-C Motif Domain Protein
THITH_03380	COG2361	Protein of unknown function DUF86
THITH_03430	COG1061	Type III restriction enzyme res subunit
THITH_03500	COG0330	HflC and HflK could
THITH_03505	COG0330	HflC and HflK could
THITH_03515	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
THITH_03520	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
THITH_03530	COG0557	exoribonuclease II activity
THITH_03535	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
THITH_03540	COG0360	Binds together with S18 to 16S ribosomal RNA
THITH_03545	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
THITH_03555	COG0359	binds to the 23S rRNA
THITH_03560	COG0305	Participates in initiation and elongation during chromosome replication
THITH_03565	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
THITH_03575	COG4783	chaperone-mediated protein folding
THITH_03585	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
THITH_03590	COG0425	Belongs to the sulfur carrier protein TusA family
THITH_03595	COG0509	glycine decarboxylation via glycine cleavage system
THITH_03600	COG4771	TonB-dependent receptor
THITH_03620	COG0095	Lipoate-protein ligase
THITH_03625	COG0028	Belongs to the TPP enzyme family
THITH_03635	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
THITH_03645	COG1183	phosphatidylcholine synthase activity
THITH_03650	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
THITH_03655	COG1573	uracil-dna glycosylase
THITH_03660	COG0456	acetyltransferase
THITH_03740	COG0517	IMP dehydrogenase activity
THITH_03745	COG4974	Belongs to the 'phage' integrase family
THITH_03750	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
THITH_03765	COG1403	HNH endonuclease
THITH_03770	COG5265	(ABC) transporter
THITH_03775	COG0514	ATP-dependent DNA helicase (RecQ)
THITH_03785	COG5001	Diguanylate cyclase
THITH_03785	COG2203	Gaf domain
THITH_03785	COG3706	GGDEF domain
THITH_03785	COG4251	negative regulation of phosphorylation
THITH_03790	COG2027	D-alanyl-D-alanine carboxypeptidase
THITH_03805	COG0525	valine-tRNA ligase activity
THITH_03815	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
THITH_03845	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
THITH_03855	COG0501	Belongs to the peptidase M48B family
THITH_03860	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
THITH_03865	COG4191	Histidine kinase
THITH_03870	COG2204	response regulator
THITH_03880	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
THITH_03885	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
THITH_03915	COG2833	Protein of unknown function (DUF455)
THITH_03920	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
THITH_03930	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
THITH_03955	COG2135	peptidase activity
THITH_03960	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
THITH_03960	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
THITH_03970	COG4636	protein conserved in cyanobacteria
THITH_03975	COG1858	cytochrome C peroxidase
THITH_04010	COG0653	protein targeting
THITH_04020	COG1858	cytochrome C peroxidase
THITH_04025	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
THITH_04030	COG0450	alkyl hydroperoxide reductase
THITH_04050	COG1648	precorrin-2 dehydrogenase activity
THITH_04050	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
THITH_04060	COG2197	response regulator
THITH_04065	COG3850	Histidine kinase
THITH_04070	COG0133	tryptophan synthase activity
THITH_04080	COG2153	protein acetylation
THITH_04085	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
THITH_04120	COG0651	ATP synthesis coupled electron transport
THITH_04125	COG0651	ATP synthesis coupled electron transport
THITH_04135	COG2111	Na H antiporter
THITH_04135	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
THITH_04140	COG1320	monovalent cation:proton antiporter activity
THITH_04175	COG0518	GMP synthase (glutamine-hydrolyzing) activity
THITH_04175	COG0519	Catalyzes the synthesis of GMP from XMP
THITH_04215	COG1215	transferase activity, transferring glycosyl groups
THITH_04250	COG2890	protein-(glutamine-N5) methyltransferase activity
THITH_04270	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
THITH_04275	COG1960	acyl-CoA dehydrogenase activity
THITH_04285	COG3161	chorismate lyase activity
THITH_04295	COG0318	PFAM AMP-dependent synthetase and ligase
THITH_04320	COG2610	gluconate transmembrane transporter activity
THITH_04325	COG0415	Belongs to the DNA photolyase family
THITH_04330	COG0789	Transcriptional regulator
THITH_04355	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
THITH_04360	COG4660	Part of a membrane complex involved in electron transport
THITH_04370	COG4658	electron transport chain
THITH_04380	COG2878	Part of a membrane complex involved in electron transport
THITH_04385	COG4657	Part of a membrane complex involved in electron transport
THITH_04390	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
THITH_04395	COG0235	Class ii aldolase
THITH_04400	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
THITH_04400	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
THITH_04405	COG0489	protein tyrosine kinase activity
THITH_04410	COG0717	Belongs to the dCTP deaminase family
THITH_04415	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
THITH_04435	COG2111	Na H antiporter
THITH_04455	COG2212	antiporter activity
THITH_04460	COG1320	monovalent cation:proton antiporter activity
THITH_04475	COG4608	Belongs to the ABC transporter superfamily
THITH_04480	COG0444	Belongs to the ABC transporter superfamily
THITH_04505	COG1115	amino acid carrier protein
THITH_04510	COG3956	TIGRFAM MazG family protein
THITH_04515	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
THITH_04515	COG1017	nitric oxide dioxygenase activity
THITH_04530	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
THITH_04530	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
THITH_04535	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
THITH_04605	COG4372	Transposase
THITH_04610	COG3436	PFAM IS66 Orf2 family protein
THITH_04620	COG3093	addiction module antidote protein HigA
THITH_04700	COG0702	epimerase
THITH_04715	COG0537	adenosine 5'-monophosphoramidase activity
THITH_04760	COG4106	trans-aconitate 2-methyltransferase activity
THITH_04770	COG2205	protein histidine kinase activity
THITH_04775	COG0745	RESPONSE REGULATOR receiver
THITH_04790	COG1366	Belongs to the anti-sigma-factor antagonist family
THITH_04805	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
THITH_04810	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
THITH_04815	COG1238	metal cluster binding
THITH_04835	COG0436	Aminotransferase
THITH_04845	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
THITH_04860	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
THITH_04875	COG1192	Involved in chromosome partitioning
THITH_04900	COG2210	Belongs to the sulfur carrier protein TusA family
THITH_04905	COG0587	DNA-directed DNA polymerase activity
THITH_04910	COG2079	MmgE PrpD family protein
THITH_04920	COG0300	oxidoreductase activity
THITH_04930	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
THITH_04940	COG0492	ferredoxin-NADP+ reductase activity
THITH_04945	COG1674	ftsk spoiiie
THITH_04955	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
THITH_04960	COG0398	Pfam SNARE associated Golgi protein
THITH_04965	COG1686	Belongs to the peptidase S11 family
THITH_04975	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
THITH_04985	COG2361	Protein of unknown function DUF86
THITH_04995	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
THITH_05015	COG0045	succinate-CoA ligase (ADP-forming) activity
THITH_05015	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
THITH_05015	COG1042	CoA-binding domain protein
THITH_05020	COG0123	including yeast histone deacetylase and acetoin utilization protein
THITH_05035	COG2267	carboxylic ester hydrolase activity
THITH_05035	COG2226	methyltransferase
THITH_05060	COG1215	transferase activity, transferring glycosyl groups
THITH_05075	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
THITH_05090	COG3360	Dodecin
THITH_05105	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
THITH_05110	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
THITH_05115	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
THITH_05115	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
THITH_05130	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
THITH_05250	COG1993	acr, cog1993
THITH_05255	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
THITH_05260	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
THITH_05310	COG2239	Acts as a magnesium transporter
THITH_05315	COG2239	Acts as a magnesium transporter
THITH_05320	COG1136	(ABC) transporter
THITH_05340	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
THITH_05345	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
THITH_05355	COG0494	nUDIX hydrolase
THITH_05380	COG3707	response regulator
THITH_05385	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
THITH_05390	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
THITH_05395	COG1116	anion transmembrane transporter activity
THITH_05400	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
THITH_05405	COG2146	nitrite reductase [NAD(P)H] activity
THITH_05410	COG0243	molybdopterin cofactor binding
THITH_05415	COG3437	response regulator, receiver
THITH_05430	COG0709	Synthesizes selenophosphate from selenide and ATP
THITH_05435	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
THITH_05440	COG1262	PFAM Formylglycine-generating sulfatase enzyme
THITH_05450	COG2226	methyltransferase
THITH_05455	COG1132	(ABC) transporter
THITH_05470	COG2200	EAL domain
THITH_05485	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
THITH_05505	COG1671	Belongs to the UPF0178 family
THITH_05520	COG0463	Glycosyl transferase, family 2
THITH_05530	COG2267	carboxylic ester hydrolase activity
THITH_05550	COG0489	protein tyrosine kinase activity
THITH_05570	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
THITH_05595	COG1848	Toxic component of a toxin-antitoxin (TA) module. An RNase
THITH_05680	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
THITH_05700	COG3657	addiction module killer protein
THITH_05710	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
THITH_05725	COG1598	PFAM Uncharacterised protein family UPF0150
THITH_05745	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
THITH_05785	COG0482	sulfurtransferase activity
THITH_05810	COG0438	transferase activity, transferring glycosyl groups
THITH_05825	COG1434	Gram-negative-bacterium-type cell wall biogenesis
THITH_05850	COG2944	sequence-specific DNA binding
THITH_05865	COG1434	Gram-negative-bacterium-type cell wall biogenesis
THITH_05935	COG1434	Gram-negative-bacterium-type cell wall biogenesis
THITH_06010	COG1434	Gram-negative-bacterium-type cell wall biogenesis
THITH_06020	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
THITH_06025	COG1086	Polysaccharide biosynthesis protein
THITH_06030	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
THITH_06070	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
THITH_06075	COG0343	queuine tRNA-ribosyltransferase activity
THITH_06080	COG1862	Preprotein translocase
THITH_06085	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
THITH_06090	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
THITH_06100	COG0247	lactate metabolic process
THITH_06105	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
THITH_06110	COG2224	Isocitrate lyase
THITH_06130	COG1262	PFAM Formylglycine-generating sulfatase enzyme
THITH_06135	COG0039	L-malate dehydrogenase activity
THITH_06140	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
THITH_06145	COG0247	lactate metabolic process
THITH_06150	COG0277	FAD linked oxidase domain protein
THITH_06155	COG0277	FAD linked oxidase domain protein
THITH_06205	COG1881	PFAM PEBP family protein
THITH_06220	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
THITH_06230	COG0291	Belongs to the bacterial ribosomal protein bL35 family
THITH_06235	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
THITH_06240	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
THITH_06245	COG0072	phenylalanine-tRNA ligase activity
THITH_06250	COG0776	regulation of translation
THITH_06265	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
THITH_06270	COG2967	ApaG domain
THITH_06275	COG0837	glucose binding
THITH_06280	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
THITH_06285	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
THITH_06290	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
THITH_06295	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
THITH_06300	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
THITH_06310	COG0772	Belongs to the SEDS family
THITH_06315	COG2951	lytic endotransglycosylase activity
THITH_06325	COG1686	Belongs to the peptidase S11 family
THITH_06335	COG2921	Belongs to the UPF0250 family
THITH_06345	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
THITH_06360	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
THITH_06380	COG1295	ribonuclease BN
THITH_06390	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
THITH_06395	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
THITH_06395	COG4797	methyltransferase
THITH_06410	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
THITH_06425	COG0348	domain, Protein
THITH_06430	COG2010	Cytochrome c
THITH_06445	COG3278	Belongs to the heme-copper respiratory oxidase family
THITH_06460	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
THITH_06470	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
THITH_06495	COG0859	PFAM glycosyl transferase family 9
THITH_06510	COG0463	Glycosyl transferase, family 2
THITH_06520	COG0438	transferase activity, transferring glycosyl groups
THITH_06565	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
THITH_06580	COG2363	Small membrane protein
THITH_06585	COG1666	GTP binding
THITH_06595	COG0723	plastoquinol--plastocyanin reductase activity
THITH_06600	COG3547	Transposase (IS116 IS110 IS902 family)
THITH_06605	COG0742	ribosomal rna small subunit methyltransferase
THITH_06615	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
THITH_06650	COG3300	MHYT domain
THITH_06650	COG5001	Diguanylate cyclase
THITH_06700	COG0741	lytic transglycosylase activity
THITH_06705	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
THITH_06705	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
THITH_06710	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
THITH_06735	COG0702	epimerase
THITH_06750	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
THITH_06755	COG0247	lactate metabolic process
THITH_06775	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
THITH_06790	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
THITH_06805	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
THITH_06810	COG0537	adenosine 5'-monophosphoramidase activity
THITH_06815	COG2133	pyrroloquinoline quinone binding
THITH_06840	COG0409	Hydrogenase expression formation protein
THITH_06860	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
THITH_06865	COG3005	denitrification pathway
THITH_06895	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
THITH_06915	COG4133	protoheme IX ABC transporter activity
THITH_06940	COG0306	phosphate transporter
THITH_06950	COG1013	pyruvate-flavodoxin oxidoreductase activity
THITH_06955	COG0674	pyruvate-flavodoxin oxidoreductase activity
THITH_06960	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
THITH_06995	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
THITH_07010	COG1250	3-hydroxyacyl-CoA dehydrogenase
THITH_07010	COG1024	Enoyl-CoA hydratase
THITH_07040	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
THITH_07050	COG0673	inositol 2-dehydrogenase activity
THITH_07055	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
THITH_07065	COG0825	malonyl-CoA metabolic process
THITH_07070	COG0037	tRNA processing
THITH_07075	COG0504	CTP synthase activity
THITH_07080	COG2877	3-deoxy-8-phosphooctulonate synthase activity
THITH_07085	COG0148	phosphopyruvate hydratase activity
THITH_07090	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
THITH_07095	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
THITH_07100	COG0095	Lipoate-protein ligase
THITH_07110	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
THITH_07135	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
THITH_07150	COG0569	domain protein
THITH_07155	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
THITH_07210	COG1196	nuclear chromosome segregation
THITH_07230	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
THITH_07245	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
THITH_07250	COG2084	Dehydrogenase
THITH_07260	COG1393	Belongs to the ArsC family
THITH_07265	COG2171	N-acyltransferase activity
THITH_07270	COG0436	Aminotransferase
THITH_07280	COG1959	2 iron, 2 sulfur cluster binding
THITH_07285	COG0719	Fe-S assembly protein
THITH_07290	COG2166	iron-sulfur cluster assembly
THITH_07295	COG0396	ATPase activity
THITH_07300	COG0719	Fe-S assembly protein
THITH_07305	COG2151	metal-sulfur cluster biosynthetic enzyme
THITH_07315	COG0316	Belongs to the HesB IscA family
THITH_07320	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
THITH_07325	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
THITH_07330	COG0471	metal ion transport
THITH_07330	COG3273	potassium ion transport
THITH_07335	COG2895	sulfate adenylyltransferase (ATP) activity
THITH_07335	COG0529	Catalyzes the synthesis of activated sulfate
THITH_07360	COG3437	response regulator, receiver
THITH_07360	COG0784	Response regulator, receiver
THITH_07365	COG0501	Belongs to the peptidase M48B family
THITH_07400	COG2078	PFAM AMMECR1 domain protein
THITH_07405	COG1355	regulation of microtubule-based process
THITH_07415	COG1024	Enoyl-CoA hydratase
THITH_07415	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
THITH_07425	COG0405	Gamma-glutamyltransferase
THITH_07445	COG0310	cobalt ion transport
THITH_07455	COG1122	ATPase activity
THITH_07460	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
THITH_07470	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
THITH_07485	COG1872	DUF167
THITH_07505	COG0348	domain, Protein
THITH_07510	COG0437	4 iron, 4 sulfur cluster binding
THITH_07515	COG0243	molybdopterin cofactor binding
THITH_07530	COG2267	carboxylic ester hydrolase activity
THITH_07535	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
THITH_07545	COG0517	IMP dehydrogenase activity
THITH_07550	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
THITH_07590	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
THITH_07595	COG4139	cobalamin transport
THITH_07600	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
THITH_07605	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
THITH_07625	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
THITH_07630	COG4566	intracellular signal transduction
THITH_07655	COG0424	maF-like protein
THITH_07660	COG0511	ligase activity, forming carbon-carbon bonds
THITH_07660	COG5016	pyruvate
THITH_07665	COG0439	Biotin carboxylase
THITH_07675	COG0333	Belongs to the bacterial ribosomal protein bL32 family
THITH_07680	COG0416	fatty acid biosynthetic process
THITH_07685	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
THITH_07695	COG1573	uracil-dna glycosylase
THITH_07700	COG0322	excinuclease ABC activity
THITH_07705	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
THITH_07720	COG1216	Glycosyl transferase, family 2
THITH_07750	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
THITH_07775	COG1595	DNA-templated transcription, initiation
THITH_07840	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
THITH_07845	COG1530	ribonuclease E activity
THITH_07850	COG3852	Histidine kinase
THITH_07880	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
THITH_07890	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
THITH_07895	COG2957	Belongs to the agmatine deiminase family
THITH_07905	COG4591	ABC-type transport system involved in lipoprotein release permease component
THITH_07910	COG1136	(ABC) transporter
THITH_07920	COG2333	competence protein COMEC
THITH_07920	COG0658	competence protein
THITH_07925	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
THITH_07935	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
THITH_07940	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
THITH_07950	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
THITH_07955	COG0287	Prephenate dehydrogenase
THITH_07960	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
THITH_07965	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
THITH_07975	COG0776	regulation of translation
THITH_07980	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
THITH_07985	COG0284	orotidine-5'-phosphate decarboxylase activity
THITH_07990	COG1596	polysaccharide export
THITH_07990	COG1555	photosystem II stabilization
THITH_07995	COG1210	Utp--glucose-1-phosphate uridylyltransferase
THITH_08020	COG0438	transferase activity, transferring glycosyl groups
THITH_08050	COG2974	May be involved in recombination
THITH_08060	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
THITH_08150	COG0516	GMP reductase activity
THITH_08150	COG0517	IMP dehydrogenase activity
THITH_08165	COG2920	part of a sulfur-relay system
THITH_08170	COG2197	response regulator
THITH_08175	COG3850	Histidine kinase
THITH_08190	COG2223	nitrite transmembrane transporter activity
THITH_08195	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
THITH_08200	COG1140	nitrate reductase beta subunit
THITH_08205	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
THITH_08210	COG2181	nitrate reductase activity
THITH_08300	COG4636	protein conserved in cyanobacteria
THITH_08360	COG2050	protein possibly involved in aromatic compounds catabolism
THITH_08365	COG0318	PFAM AMP-dependent synthetase and ligase
THITH_08385	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
THITH_08405	COG0714	Associated with various cellular activities
THITH_08430	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
THITH_08445	COG3901	Regulator of nitric oxide reductase transcription
THITH_08445	COG0348	domain, Protein
THITH_08460	COG2373	Large extracellular alpha-helical protein
THITH_08465	COG4953	penicillin-binding protein 1C
THITH_08505	COG1136	(ABC) transporter
THITH_08510	COG0577	efflux transmembrane transporter activity
THITH_08510	COG1136	(ABC) transporter
THITH_08550	COG3548	integral membrane protein
THITH_08580	COG1335	isochorismatase
THITH_08620	COG1472	Belongs to the glycosyl hydrolase 3 family
THITH_08695	COG1509	lysine 2,3-aminomutase activity
THITH_08700	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
THITH_08715	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
THITH_08720	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
THITH_08730	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
THITH_08735	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
THITH_08740	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
THITH_08745	COG1028	Short-chain dehydrogenase reductase Sdr
THITH_08750	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
THITH_08755	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
THITH_08760	COG0542	response to heat
THITH_08765	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
THITH_08780	COG0482	sulfurtransferase activity
THITH_08785	COG2915	High frequency lysogenization protein hflD homolog
THITH_08790	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
THITH_08805	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
THITH_08810	COG0114	fumarate hydratase activity
THITH_08820	COG2850	peptidyl-arginine hydroxylation
THITH_08865	COG2217	Heavy metal translocating P-type atpase
THITH_08870	COG2863	cytochrome
THITH_08880	COG2217	Heavy metal translocating P-type atpase
THITH_08915	COG0745	RESPONSE REGULATOR receiver
THITH_08920	COG2205	protein histidine kinase activity
THITH_08925	COG4243	Vitamin k epoxide reductase
THITH_08945	COG5002	protein histidine kinase activity
THITH_08955	COG0070	glutamate synthase
THITH_08955	COG0069	glutamate synthase activity
THITH_08955	COG0067	glutamate synthase
THITH_08970	COG3706	GGDEF domain
THITH_08975	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
THITH_08985	COG0446	pyridine nucleotide-disulphide oxidoreductase
THITH_09020	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
THITH_09025	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
THITH_09030	COG1131	(ABC) transporter
THITH_09035	COG0842	Transport permease protein
THITH_09040	COG0739	heme binding
THITH_09045	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
THITH_09045	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
THITH_09055	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
THITH_09055	COG0069	glutamate synthase activity
THITH_09060	COG0259	pyridoxamine-phosphate oxidase activity
THITH_09085	COG0402	S-adenosylhomocysteine deaminase activity
THITH_09090	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
THITH_09100	COG1322	Protein conserved in bacteria
THITH_09110	COG1562	ergosterol biosynthetic process
THITH_09115	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
THITH_09120	COG4566	intracellular signal transduction
THITH_09125	COG4191	Histidine kinase
THITH_09135	COG1028	Short-chain dehydrogenase reductase Sdr
THITH_09155	COG0167	dihydroorotate dehydrogenase activity
THITH_09180	COG0488	(ABC) transporter
THITH_09190	COG0071	Belongs to the small heat shock protein (HSP20) family
THITH_09205	COG2199	diguanylate cyclase activity
THITH_09205	COG2202	Pas domain
THITH_09205	COG2200	EAL domain
THITH_09235	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
THITH_09245	COG1518	maintenance of DNA repeat elements
THITH_09245	COG1468	defense response to virus
THITH_09250	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
THITH_09320	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
THITH_09345	COG1337	RAMP superfamily
THITH_09360	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
THITH_09370	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
THITH_09380	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
THITH_09385	COG2137	regulation of response to DNA damage stimulus
THITH_09390	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
THITH_09395	COG1058	Belongs to the CinA family
THITH_09395	COG1546	Belongs to the CinA family
THITH_09400	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
THITH_09405	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
THITH_09415	COG0033	Phosphoglucomutase
THITH_09425	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
THITH_09435	COG1053	succinate dehydrogenase
THITH_09440	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
THITH_09460	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
THITH_09480	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
THITH_09490	COG1012	belongs to the aldehyde dehydrogenase family
THITH_09495	COG0473	3-isopropylmalate dehydrogenase activity
THITH_09540	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
THITH_09545	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
THITH_09550	COG0180	Tryptophanyl-tRNA synthetase
THITH_09560	COG1994	Peptidase M50
THITH_09565	COG0009	L-threonylcarbamoyladenylate synthase
THITH_09570	COG2350	Protein conserved in bacteria
THITH_09575	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
THITH_09580	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
THITH_09585	COG3115	cell septum assembly
THITH_09590	COG1196	nuclear chromosome segregation
THITH_09595	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
THITH_09600	COG1070	Carbohydrate kinase
THITH_09610	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
THITH_09620	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
THITH_09625	COG2738	Putative neutral zinc metallopeptidase
THITH_09630	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
THITH_09635	COG2894	cell division
THITH_09640	COG0850	regulation of cytokinetic process
THITH_09710	COG1335	isochorismatase
THITH_09715	COG0372	Belongs to the citrate synthase family
THITH_09725	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
THITH_09765	COG1404	Belongs to the peptidase S8 family
THITH_09770	COG1404	Belongs to the peptidase S8 family
THITH_09795	COG2801	Transposase and inactivated derivatives
THITH_09850	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
THITH_09855	COG1216	Glycosyl transferase, family 2
THITH_09875	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
THITH_09890	COG0438	transferase activity, transferring glycosyl groups
THITH_09900	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
THITH_09945	COG2943	transferase activity, transferring hexosyl groups
THITH_09950	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
THITH_09975	COG0471	metal ion transport
THITH_09985	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
THITH_09990	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
THITH_10010	COG0121	glutamine amidotransferase
THITH_10050	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
THITH_10065	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
THITH_10070	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
THITH_10085	COG1132	(ABC) transporter
THITH_10095	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
THITH_10100	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
THITH_10125	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
THITH_10135	COG1216	Glycosyl transferase, family 2
THITH_10160	COG1450	Type ii and iii secretion system protein
THITH_10205	COG1459	type II secretion system
THITH_10210	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
THITH_10235	COG4717	serine-type aminopeptidase activity
THITH_10240	COG0420	3'-5' exonuclease activity
THITH_10255	COG1388	LysM domain
THITH_10255	COG0741	lytic transglycosylase activity
THITH_10260	COG2989	Protein conserved in bacteria
THITH_10280	COG4251	negative regulation of phosphorylation
THITH_10280	COG5001	Diguanylate cyclase
THITH_10280	COG2203	Gaf domain
THITH_10280	COG3706	GGDEF domain
THITH_10295	COG2208	phosphoserine phosphatase activity
THITH_10320	COG1007	ATP synthesis coupled electron transport
THITH_10330	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
THITH_10335	COG0713	ATP synthesis coupled electron transport
THITH_10345	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
THITH_10350	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
THITH_10355	COG1034	ATP synthesis coupled electron transport
THITH_10370	COG0649	NAD binding
THITH_10375	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
THITH_10380	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
THITH_10385	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
THITH_10390	COG0058	SHG alpha-glucan phosphorylase activity
THITH_10400	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
THITH_10405	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
THITH_10410	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
THITH_10425	COG0750	zinc metalloprotease
THITH_10430	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
THITH_10435	COG0575	Belongs to the CDS family
THITH_10440	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
THITH_10445	COG0233	cytoplasmic translational termination
THITH_10450	COG0528	UMP kinase activity
THITH_10455	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
THITH_10465	COG0024	Methionine aminopeptidase
THITH_10470	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
THITH_10480	COG1643	Atp-dependent helicase
THITH_10525	COG4181	ATPase activity
THITH_10530	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
THITH_10535	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
THITH_10575	COG2133	pyrroloquinoline quinone binding
THITH_10595	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
THITH_10600	COG1053	succinate dehydrogenase
THITH_10620	COG1234	tRNA 3'-trailer cleavage
THITH_10625	COG0430	RNA-3'-phosphate cyclase activity
THITH_10640	COG0788	formyltetrahydrofolate deformylase activity
THITH_10645	COG3243	poly(R)-hydroxyalkanoic acid synthase
THITH_10660	COG5394	Polyhydroxyalkanoate synthesis repressor PhaR
THITH_10670	COG1028	Short-chain dehydrogenase reductase Sdr
THITH_10675	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
THITH_10680	COG0590	tRNA wobble adenosine to inosine editing
THITH_10690	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
THITH_10690	COG3008	intermembrane lipid transfer
THITH_10695	COG1127	ABC transporter
THITH_10700	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
THITH_10705	COG0714	Associated with various cellular activities
THITH_10720	COG1959	2 iron, 2 sulfur cluster binding
THITH_10725	COG1376	ErfK ybiS ycfS ynhG family protein
THITH_10735	COG1286	toxin biosynthetic process
THITH_10745	COG0285	dihydrofolate synthase activity
THITH_10750	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
THITH_10755	COG0159	tryptophan synthase activity
THITH_10760	COG0133	tryptophan synthase activity
THITH_10785	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
THITH_10790	COG0473	3-isopropylmalate dehydrogenase activity
THITH_10795	COG0066	3-isopropylmalate dehydratase activity
THITH_10800	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
THITH_10805	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
THITH_10850	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
THITH_10855	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
THITH_10875	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
THITH_10885	COG3842	ATPase activity
THITH_10890	COG0395	ABC-type sugar transport system, permease component
THITH_10895	COG1175	transmembrane transport
THITH_10925	COG0429	hydrolase of the alpha beta-hydrolase fold
THITH_10940	COG0433	COG0433 Predicted ATPase
THITH_10955	COG0446	pyridine nucleotide-disulphide oxidoreductase
THITH_10970	COG0418	dihydroorotase activity
THITH_10975	COG3318	Belongs to the UPF0149 family
THITH_10975	COG3012	SEC-C Motif Domain Protein
THITH_11020	COG0471	metal ion transport
THITH_11020	COG3273	potassium ion transport
THITH_11025	COG0653	protein targeting
THITH_11035	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
THITH_11040	COG3177	Filamentation induced by cAMP protein fic
THITH_11045	COG2161	toxin-antitoxin pair type II binding
THITH_11050	COG4115	mRNA cleavage
THITH_11090	COG2161	toxin-antitoxin pair type II binding
THITH_11095	COG4636	protein conserved in cyanobacteria
THITH_11110	COG1487	ribonuclease activity
THITH_11115	COG0210	DNA helicase
THITH_11145	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
THITH_11175	COG0517	IMP dehydrogenase activity
THITH_11180	COG4974	Belongs to the 'phage' integrase family
THITH_11185	COG4372	Transposase
THITH_11200	COG3436	PFAM IS66 Orf2 family protein
THITH_11210	COG4974	Belongs to the 'phage' integrase family
THITH_11220	COG0154	amidase activity
THITH_11275	COG3387	PFAM Glycoside hydrolase 15-related
THITH_11290	COG0318	PFAM AMP-dependent synthetase and ligase
THITH_11350	COG1331	Highly conserved protein containing a thioredoxin domain
THITH_11355	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
THITH_11360	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
THITH_11365	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
THITH_11375	COG1108	ABC-type Mn2 Zn2 transport systems permease components
THITH_11380	COG1121	(ABC) transporter
THITH_11390	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
THITH_11395	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
THITH_11400	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
THITH_11410	COG0404	The glycine cleavage system catalyzes the degradation of glycine
THITH_11415	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
THITH_11420	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
THITH_11425	COG0006	proline dipeptidase activity
THITH_11430	COG3079	Belongs to the UPF0149 family
THITH_11445	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
THITH_11460	COG2205	protein histidine kinase activity
THITH_11505	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
THITH_11515	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
THITH_11520	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
THITH_11540	COG3220	belongs to the UPF0276 family
THITH_11555	COG2207	Transcriptional regulator
THITH_11570	COG1968	undecaprenyl-diphosphatase activity
THITH_11610	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
THITH_11615	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
THITH_11625	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
THITH_11630	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
THITH_11640	COG0671	phosphoesterase, PA-phosphatase related
THITH_11645	COG0469	pyruvate kinase activity
THITH_11655	COG0438	transferase activity, transferring glycosyl groups
THITH_11665	COG3383	formate dehydrogenase (NAD+) activity
THITH_11665	COG0243	molybdopterin cofactor binding
THITH_11670	COG0243	molybdopterin cofactor binding
THITH_11670	COG3383	formate dehydrogenase (NAD+) activity
THITH_11675	COG0437	4 iron, 4 sulfur cluster binding
THITH_11680	COG2864	formate dehydrogenase
THITH_11685	COG3058	Necessary for formate dehydrogenase activity
THITH_11725	COG3276	selenocysteine insertion sequence binding
THITH_11735	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
THITH_11740	COG3639	organic phosphonate transmembrane transporter activity
THITH_11745	COG0709	Synthesizes selenophosphate from selenide and ATP
THITH_11780	COG1741	Belongs to the pirin family
THITH_11790	COG0704	Plays a role in the regulation of phosphate uptake
THITH_11795	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
THITH_11800	COG0581	inorganic phosphate transmembrane transporter activity
THITH_11820	COG0545	Peptidyl-prolyl cis-trans isomerase
THITH_11845	COG3706	GGDEF domain
THITH_11850	COG2988	succinylglutamate desuccinylase activity
THITH_11860	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
THITH_11865	COG0215	cysteine-tRNA ligase activity
THITH_11875	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
THITH_11880	COG1022	Amp-dependent synthetase and ligase
THITH_11885	COG0436	Aminotransferase
THITH_11890	COG1160	GTP binding
THITH_11895	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
THITH_11905	COG0124	histidyl-tRNA synthetase
THITH_11920	COG0820	rRNA (adenine-C2-)-methyltransferase activity
THITH_11925	COG0105	UTP biosynthetic process
THITH_11960	COG2920	part of a sulfur-relay system
THITH_11980	COG2221	Nitrite and sulphite reductase 4Fe-4S
THITH_11985	COG2221	Nitrite and sulphite reductase 4Fe-4S
THITH_11990	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
THITH_11995	COG2923	Belongs to the DsrF TusC family
THITH_12005	COG2920	part of a sulfur-relay system
THITH_12040	COG1797	cobyrinic acid a,c-diamide synthase activity
THITH_12050	COG3128	pkhd-type hydroxylase
THITH_12065	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
THITH_12070	COG2835	tetraacyldisaccharide 4'-kinase activity
THITH_12075	COG1663	tetraacyldisaccharide 4'-kinase activity
THITH_12085	COG1132	(ABC) transporter
THITH_12090	COG0848	biopolymer transport protein
THITH_12095	COG0811	peptide transport
THITH_12100	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
THITH_12115	COG0736	holo-[acyl-carrier-protein] synthase activity
THITH_12120	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
THITH_12130	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
THITH_12135	COG0571	ribonuclease III activity
THITH_12145	COG0681	Belongs to the peptidase S26 family
THITH_12150	COG0481	GTPase activity
THITH_12160	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
THITH_12190	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
THITH_12205	COG1162	GTPase activity
THITH_12215	COG0537	adenosine 5'-monophosphoramidase activity
THITH_12220	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
THITH_12225	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
THITH_12230	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
THITH_12230	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
THITH_12235	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
THITH_12235	COG0678	peroxiredoxin activity
THITH_12245	COG0585	pseudouridine synthase activity
THITH_12255	COG1199	ATP-dependent helicase activity
THITH_12265	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
THITH_12280	COG0791	NLP P60 protein
THITH_12290	COG0521	Mo-molybdopterin cofactor biosynthetic process
THITH_12295	COG2166	iron-sulfur cluster assembly
THITH_12305	COG0583	DNA-binding transcription factor activity
THITH_12325	COG2193	ferroxidase activity
THITH_12365	COG4451	ribulose bisphosphate carboxylase, small
THITH_12370	COG1850	ribulose-bisphosphate carboxylase activity
THITH_12380	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
THITH_12400	COG1917	Cupin 2, conserved barrel domain protein
THITH_12400	COG2207	Transcriptional regulator
THITH_12410	COG4681	YaeQ
THITH_12425	COG0583	DNA-binding transcription factor activity
THITH_12430	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
THITH_12470	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
THITH_12480	COG1215	transferase activity, transferring glycosyl groups
THITH_12495	COG1215	transferase activity, transferring glycosyl groups
THITH_12530	COG1192	Involved in chromosome partitioning
THITH_12540	COG2766	serine protein kinase
THITH_12545	COG2718	Belongs to the UPF0229 family
THITH_12550	COG2719	SpoVR family
THITH_12555	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
THITH_12590	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
THITH_12605	COG0545	Peptidyl-prolyl cis-trans isomerase
THITH_12630	COG2951	lytic endotransglycosylase activity
THITH_12655	COG2226	methyltransferase
THITH_12710	COG3706	GGDEF domain
THITH_12715	COG0590	tRNA wobble adenosine to inosine editing
THITH_12720	COG1715	Restriction endonuclease
THITH_12765	COG0822	iron-sulfur transferase activity
THITH_12790	COG0519	Catalyzes the synthesis of GMP from XMP
THITH_12790	COG0518	GMP synthase (glutamine-hydrolyzing) activity
THITH_12800	COG1570	exodeoxyribonuclease VII activity
THITH_12805	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
THITH_12810	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
THITH_12815	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
THITH_12825	COG2205	protein histidine kinase activity
THITH_12830	COG2204	response regulator
THITH_12845	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
THITH_12860	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
THITH_12875	COG2308	Evidence 4 Homologs of previously reported genes of
THITH_12885	COG1185	polyribonucleotide nucleotidyltransferase activity
THITH_12890	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
THITH_12895	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
THITH_12900	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
THITH_12905	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
THITH_12910	COG0195	Participates in both transcription termination and antitermination
THITH_12910	COG2251	uridine kinase activity
THITH_12925	COG1007	ATP synthesis coupled electron transport
THITH_12940	COG0713	ATP synthesis coupled electron transport
THITH_12950	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
THITH_12955	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
THITH_12960	COG1034	ATP synthesis coupled electron transport
THITH_12975	COG0649	NAD binding
THITH_12980	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
THITH_12985	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
THITH_12990	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
THITH_13005	COG0149	triose-phosphate isomerase activity
THITH_13010	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
THITH_13015	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
THITH_13020	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
THITH_13025	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
THITH_13030	COG1534	Rna-binding protein
THITH_13035	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
THITH_13040	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
THITH_13045	COG0505	Belongs to the CarA family
THITH_13055	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
THITH_13070	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
THITH_13090	COG0688	phosphatidylethanolamine metabolic process
THITH_13095	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
THITH_13100	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
THITH_13105	COG1509	lysine 2,3-aminomutase activity
THITH_13115	COG2200	EAL domain
THITH_13120	COG0484	heat shock protein binding
THITH_13125	COG0443	Heat shock 70 kDa protein
THITH_13130	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
THITH_13135	COG1420	regulation of RNA biosynthetic process
THITH_13140	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
THITH_13145	COG0497	DNA recombination
THITH_13150	COG0735	belongs to the Fur family
THITH_13155	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
THITH_13160	COG2914	Belongs to the UPF0125 (RnfH) family
THITH_13165	COG2867	negative regulation of translational initiation
THITH_13170	COG0733	neurotransmitter:sodium symporter activity
THITH_13175	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
THITH_13180	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
THITH_13185	COG0328	RNA-DNA hybrid ribonuclease activity
THITH_13215	COG0432	Pfam Uncharacterised protein family UPF0047
THITH_13220	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
THITH_13230	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
THITH_13240	COG1858	cytochrome C peroxidase
THITH_13255	COG0811	peptide transport
THITH_13260	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
THITH_13275	COG4206	TonB-dependent receptor
THITH_13285	COG0446	pyridine nucleotide-disulphide oxidoreductase
THITH_13295	COG2204	response regulator
THITH_13300	COG2205	protein histidine kinase activity
THITH_13315	COG0577	efflux transmembrane transporter activity
THITH_13315	COG1136	(ABC) transporter
THITH_13320	COG0577	efflux transmembrane transporter activity
THITH_13320	COG1136	(ABC) transporter
THITH_13325	COG1136	(ABC) transporter
THITH_13330	COG1136	(ABC) transporter
THITH_13330	COG0577	efflux transmembrane transporter activity
THITH_13345	COG1276	copper resistance
THITH_13350	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
THITH_13355	COG2095	MarC family integral membrane protein
THITH_13420	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
THITH_13425	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
THITH_13440	COG0544	peptidyl-prolyl cis-trans isomerase activity
THITH_13450	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
THITH_13455	COG1923	regulation of RNA biosynthetic process
THITH_13460	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
THITH_13465	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
THITH_13470	COG0860	N-Acetylmuramoyl-L-alanine amidase
THITH_13475	COG0802	atpase or kinase
THITH_13480	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
THITH_13480	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
THITH_13495	COG3118	belongs to the thioredoxin family
THITH_13510	COG0330	HflC and HflK could
THITH_13520	COG1763	Mo-molybdopterin cofactor biosynthetic process
THITH_13525	COG0303	'Molybdopterin
THITH_13550	COG1136	(ABC) transporter
THITH_13550	COG0577	efflux transmembrane transporter activity
THITH_13565	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
THITH_13585	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
THITH_13600	COG0166	Belongs to the GPI family
THITH_13605	COG0297	glycogen (starch) synthase activity
THITH_13610	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
THITH_13615	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
THITH_13620	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
THITH_13625	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
THITH_13630	COG1428	Deoxynucleoside kinase
THITH_13635	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
THITH_13640	COG0617	tRNA 3'-terminal CCA addition
THITH_13650	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
THITH_13655	COG0625	glutathione transferase activity
THITH_13660	COG2983	Belongs to the UPF0260 family
THITH_13680	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
THITH_13685	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
THITH_13690	COG0363	glucosamine-6-phosphate deaminase activity
THITH_13715	COG4943	cyclic-guanylate-specific phosphodiesterase activity
THITH_13720	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
THITH_13735	COG0438	transferase activity, transferring glycosyl groups
THITH_13740	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
THITH_13745	COG2944	sequence-specific DNA binding
THITH_13815	COG0737	Belongs to the 5'-nucleotidase family
THITH_13820	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
THITH_13835	COG3028	Belongs to the UPF0307 family
THITH_13855	COG2124	cytochrome p450
THITH_13865	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
THITH_13875	COG0720	synthase
THITH_13880	COG2183	response to ionizing radiation
THITH_13940	COG1271	oxidase subunit
THITH_13945	COG1294	oxidase, subunit
THITH_13950	COG4988	ABC transporter
THITH_13955	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
THITH_13965	COG2200	EAL domain
THITH_13965	COG2199	diguanylate cyclase activity
THITH_13965	COG2202	Pas domain
THITH_13970	COG0542	response to heat
THITH_13995	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
THITH_13995	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
THITH_14000	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
THITH_14005	COG0045	succinate-CoA ligase (ADP-forming) activity
THITH_14025	COG0424	maF-like protein
THITH_14030	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
THITH_14040	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
THITH_14045	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
THITH_14060	COG0495	leucyl-tRNA aminoacylation
THITH_14065	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
THITH_14070	COG0058	SHG alpha-glucan phosphorylase activity
THITH_14105	COG1136	(ABC) transporter
THITH_14120	COG0815	Transfers the fatty acyl group on membrane lipoproteins
THITH_14125	COG4535	Mg2 and Co2 transporter CorC
THITH_14130	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
THITH_14135	COG1702	phosphate starvation-inducible protein PhoH
THITH_14140	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
THITH_14150	COG2814	Major facilitator Superfamily
THITH_14155	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
THITH_14160	COG0203	ribosomal protein L17
THITH_14165	COG0202	RNA polymerase activity
THITH_14170	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
THITH_14175	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
THITH_14180	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
THITH_14185	COG0257	Belongs to the bacterial ribosomal protein bL36 family
THITH_14190	COG0201	protein transport
THITH_14195	COG0200	Binds to the 23S rRNA
THITH_14200	COG1841	ribosomal large subunit assembly
THITH_14205	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
THITH_14210	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
THITH_14215	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
THITH_14220	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
THITH_14225	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
THITH_14230	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
THITH_14235	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
THITH_14240	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
THITH_14245	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
THITH_14250	COG0255	Belongs to the universal ribosomal protein uL29 family
THITH_14255	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
THITH_14260	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
THITH_14265	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
THITH_14270	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
THITH_14275	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
THITH_14280	COG0089	rRNA binding
THITH_14285	COG0088	Forms part of the polypeptide exit tunnel
THITH_14290	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
THITH_14295	COG0051	transcription antitermination factor activity, RNA binding
THITH_14300	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
THITH_14305	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
THITH_14310	COG0049	tRNA binding
THITH_14315	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
THITH_14320	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
THITH_14325	COG0085	RNA polymerase activity
THITH_14330	COG0222	ribosome binding
THITH_14335	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
THITH_14340	COG0081	regulation of translation
THITH_14345	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
THITH_14365	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
THITH_14385	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
THITH_14405	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
THITH_14410	COG0494	nUDIX hydrolase
THITH_14415	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
THITH_14420	COG0653	protein targeting
THITH_14430	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
THITH_14435	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
THITH_14445	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
THITH_14450	COG1181	Belongs to the D-alanine--D-alanine ligase family
THITH_14455	COG0812	UDP-N-acetylmuramate dehydrogenase activity
THITH_14460	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
THITH_14465	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
THITH_14470	COG0772	Belongs to the SEDS family
THITH_14475	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
THITH_14480	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
THITH_14485	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
THITH_14490	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
THITH_14500	COG3116	cell division
THITH_14505	COG0275	rRNA processing
THITH_14510	COG2001	Belongs to the MraZ family
THITH_14525	COG3107	peptidoglycan biosynthetic process
THITH_14530	COG0792	nuclease activity
THITH_14535	COG0277	FAD linked oxidase domain protein
THITH_14540	COG2969	positive regulation of protein catabolic process
THITH_14545	COG0625	glutathione transferase activity
THITH_14550	COG2857	Cytochrome c1
THITH_14555	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
THITH_14560	COG0723	plastoquinol--plastocyanin reductase activity
THITH_14570	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
THITH_14575	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
THITH_14585	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
THITH_14590	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
THITH_14595	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
THITH_14610	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
THITH_14615	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
THITH_14620	COG1127	ABC transporter
THITH_14655	COG1137	ATPase activity
THITH_14675	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
THITH_14680	COG1660	Displays ATPase and GTPase activities
THITH_14705	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
THITH_14720	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
THITH_14730	COG2853	Lipoprotein
THITH_14735	COG0137	argininosuccinate synthase activity
THITH_14740	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
THITH_14745	COG0508	dehydrogenase complex catalyzes the overall conversion of
THITH_14755	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
THITH_14760	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
THITH_14765	COG0012	GTP binding
THITH_14770	COG0193	aminoacyl-tRNA hydrolase activity
THITH_14775	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
THITH_14780	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
THITH_14790	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
THITH_14805	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
THITH_14810	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
THITH_14825	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
THITH_14830	COG0308	aminopeptidase N
THITH_14835	COG0084	hydrolase, TatD family'
THITH_14840	COG0271	Belongs to the BolA IbaG family
THITH_14865	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
THITH_14910	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
THITH_14920	COG0828	Belongs to the bacterial ribosomal protein bS21 family
THITH_14925	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
THITH_14930	COG0232	Belongs to the dGTPase family. Type 2 subfamily
THITH_14940	COG1120	ATPase activity
THITH_14945	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
THITH_14950	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
THITH_14955	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
THITH_14995	COG4206	TonB-dependent receptor
THITH_15005	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
THITH_15065	COG3657	addiction module killer protein
THITH_15070	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
THITH_15140	COG0582	viral genome integration into host DNA
THITH_15175	COG3706	GGDEF domain
THITH_15190	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
THITH_15195	COG1840	ABC-type Fe3 transport system, periplasmic component
THITH_15200	COG1178	ABC-type Fe3 transport system permease component
THITH_15205	COG3842	ATPase activity
THITH_15210	COG0729	surface antigen
THITH_15215	COG2911	Protein conserved in bacteria
THITH_15230	COG1136	(ABC) transporter
THITH_15230	COG0577	efflux transmembrane transporter activity
THITH_15240	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
THITH_15265	COG2885	chlorophyll binding
THITH_15265	COG3047	cAMP biosynthetic process
THITH_15270	COG0459	protein refolding
THITH_15275	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
THITH_15300	COG1324	tolerance protein
THITH_15305	COG4232	protein-disulfide reductase activity
THITH_15310	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
THITH_15320	COG0511	ligase activity, forming carbon-carbon bonds
THITH_15325	COG0439	Biotin carboxylase
THITH_15330	COG2264	protein methyltransferase activity
THITH_15390	COG0129	dihydroxy-acid dehydratase activity
THITH_15405	COG3264	Mechanosensitive ion channel
THITH_15405	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
THITH_15420	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
THITH_15420	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
THITH_15430	COG1309	transcriptional regulator
THITH_15445	COG4372	Transposase
THITH_15450	COG3436	PFAM IS66 Orf2 family protein
THITH_15465	COG1741	Belongs to the pirin family
THITH_15480	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
THITH_15490	COG0390	transport system, permease component
THITH_15500	COG0004	ammonium transporteR
THITH_15520	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
THITH_15530	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
THITH_15535	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
THITH_15555	COG0569	domain protein
THITH_15560	COG2204	response regulator
THITH_15565	COG5000	phosphorelay sensor kinase activity
THITH_15575	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
THITH_15580	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
THITH_15585	COG0242	peptide deformylase activity
THITH_15595	COG0758	DNA mediated transformation
THITH_15600	COG2922	Belongs to the Smg family
THITH_15610	COG0009	L-threonylcarbamoyladenylate synthase
THITH_15615	COG0408	coproporphyrinogen oxidase activity
THITH_15625	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
THITH_15630	COG2885	chlorophyll binding
THITH_15635	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
THITH_15650	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
THITH_15655	COG0156	8-amino-7-oxononanoate synthase activity
THITH_15660	COG2210	Belongs to the sulfur carrier protein TusA family
THITH_15670	COG2003	Belongs to the UPF0758 family
THITH_15675	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
THITH_15685	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
THITH_15730	COG3100	YcgL domain-containing protein
THITH_15735	COG1166	arginine decarboxylase activity
THITH_15740	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
THITH_15745	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
THITH_15750	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
THITH_15755	COG3178	'Phosphotransferase
THITH_15760	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
THITH_15775	COG1595	DNA-templated transcription, initiation
THITH_15795	COG1924	4 iron, 4 sulfur cluster binding
THITH_15810	COG1247	-acetyltransferase
THITH_15830	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
THITH_15835	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
THITH_15840	COG1765	OsmC-like protein
THITH_15850	COG0134	indole-3-glycerol-phosphate synthase activity
THITH_15855	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
THITH_15880	COG0546	phosphoglycolate phosphatase activity
THITH_15900	COG2813	Specifically methylates the guanine in position
THITH_15905	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
THITH_15910	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
THITH_15915	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
THITH_15920	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
THITH_15930	COG0191	fructose-bisphosphate aldolase activity
THITH_15935	COG0469	pyruvate kinase activity
THITH_15940	COG0126	phosphoglycerate kinase activity
THITH_15945	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
THITH_15950	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
THITH_15955	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
THITH_15960	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
THITH_15965	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
THITH_15970	COG1385	rRNA (uridine-N3-)-methyltransferase activity
THITH_15980	COG0189	ligase activity
THITH_16000	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
THITH_16005	COG1678	Uncharacterized ACR, COG1678
THITH_16020	COG0540	Belongs to the ATCase OTCase family
THITH_16075	COG1011	Hydrolase
THITH_16085	COG0494	nUDIX hydrolase
THITH_16115	COG0438	transferase activity, transferring glycosyl groups
THITH_16120	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
THITH_16125	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
THITH_16130	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
THITH_16135	COG2918	glutathione biosynthetic process
THITH_16145	COG2197	response regulator
THITH_16150	COG3850	Histidine kinase
THITH_16160	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
THITH_16170	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
THITH_16195	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
THITH_16205	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
THITH_16215	COG0446	pyridine nucleotide-disulphide oxidoreductase
THITH_16220	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
THITH_16225	COG0488	(ABC) transporter
THITH_16250	COG0483	inositol monophosphate 1-phosphatase activity
THITH_16290	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
THITH_16290	COG3153	acetyltransferase
THITH_16295	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
THITH_16315	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
THITH_16320	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
THITH_16340	COG0151	Belongs to the GarS family
THITH_16345	COG0058	SHG alpha-glucan phosphorylase activity
THITH_16350	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
THITH_16355	COG0254	rRNA binding
THITH_16365	COG0281	malic enzyme
THITH_16370	COG0039	L-malate dehydrogenase activity
THITH_16390	COG0741	lytic transglycosylase activity
THITH_16415	COG2197	response regulator
THITH_16435	COG0742	ribosomal rna small subunit methyltransferase
THITH_16440	COG0612	Peptidase, M16
THITH_16445	COG0612	Peptidase, M16
THITH_16450	COG0552	protein localization to endoplasmic reticulum
THITH_16455	COG2884	Cell division ATP-binding protein ftsE
THITH_16475	COG1104	cysteine desulfurase activity
THITH_16495	COG2217	Heavy metal translocating P-type atpase
THITH_16505	COG0348	domain, Protein
THITH_16510	COG2010	Cytochrome c
THITH_16525	COG3278	Belongs to the heme-copper respiratory oxidase family
THITH_16530	COG2226	methyltransferase
THITH_16535	COG0596	Alpha beta hydrolase
THITH_16540	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
THITH_16545	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
THITH_16555	COG1028	Short-chain dehydrogenase reductase Sdr
THITH_16560	COG2960	long-chain fatty acid transporting porin activity
THITH_16565	COG0606	chelatase, subunit chli
THITH_16585	COG1487	ribonuclease activity
THITH_16590	COG4691	Plasmid stability protein
THITH_16595	COG0398	Pfam SNARE associated Golgi protein
THITH_16605	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
THITH_16620	COG3093	addiction module antidote protein HigA
THITH_16660	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
THITH_16670	COG4941	Belongs to the sigma-70 factor family
THITH_16690	COG3795	YCII-related domain
THITH_16715	COG0701	Predicted permease
THITH_16725	COG0243	molybdopterin cofactor binding
THITH_16730	COG0437	4 iron, 4 sulfur cluster binding
THITH_16745	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
THITH_16750	COG0517	IMP dehydrogenase activity
THITH_16755	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
THITH_16765	COG3041	Addiction module toxin RelE StbE family
THITH_16770	COG3077	Addiction module antitoxin, RelB DinJ family
THITH_16810	COG1136	(ABC) transporter
THITH_16845	COG3852	Histidine kinase
THITH_16850	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
THITH_16870	COG0745	RESPONSE REGULATOR receiver
THITH_16870	COG3706	GGDEF domain
THITH_16925	COG0194	GDP metabolic process
THITH_16930	COG1758	RNA polymerase activity
THITH_16935	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
THITH_16955	COG0037	tRNA processing
THITH_16960	COG0445	tRNA wobble uridine modification
THITH_16965	COG0357	Ribosomal RNA small subunit methyltransferase G
THITH_16970	COG1192	Involved in chromosome partitioning
THITH_16975	COG1475	DNA binding
THITH_16985	COG0356	it plays a direct role in the translocation of protons across the membrane
THITH_16995	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
THITH_17000	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
THITH_17005	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
THITH_17010	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
THITH_17015	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
THITH_17020	COG0355	proton-transporting ATP synthase activity, rotational mechanism
THITH_17025	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
THITH_17030	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
THITH_17040	COG1628	Protein of unknown function DUF99
THITH_17055	COG0561	phosphatase activity
THITH_17055	COG3100	YcgL domain-containing protein
THITH_17065	COG0793	Belongs to the peptidase S41A family
THITH_17070	COG4942	peptidase
THITH_17075	COG0640	Transcriptional regulator
THITH_17080	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
THITH_17095	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
THITH_17100	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
THITH_17105	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
THITH_17115	COG3852	Histidine kinase
THITH_17130	COG1611	Belongs to the LOG family
THITH_17145	COG1999	signal sequence binding
THITH_17155	COG0218	Necessary for normal cell division and for the maintenance of normal septation
THITH_17185	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
THITH_17185	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
THITH_17195	COG2197	response regulator
THITH_17200	COG2197	response regulator
THITH_17230	COG0367	asparagine synthase
THITH_17235	COG0540	Belongs to the ATCase OTCase family
THITH_17240	COG1335	isochorismatase
THITH_17250	COG1846	Transcriptional regulator
THITH_17260	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
THITH_17280	COG0708	Exodeoxyribonuclease III
THITH_17285	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
THITH_17290	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
THITH_17310	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
THITH_17315	COG0513	Belongs to the DEAD box helicase family
THITH_17320	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
THITH_17325	COG0205	6-phosphofructokinase activity
THITH_17340	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
THITH_17345	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
THITH_17350	COG0405	Gamma-glutamyltransferase
THITH_17375	COG1183	phosphatidylcholine synthase activity
THITH_17385	COG0508	dehydrogenase complex catalyzes the overall conversion of
THITH_17395	COG0210	DNA helicase
THITH_17420	COG0446	pyridine nucleotide-disulphide oxidoreductase
THITH_17445	COG1490	D-aminoacyl-tRNA deacylase activity
THITH_17450	COG1394	ATPase activity, coupled to movement of substances
THITH_17455	COG1156	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit
THITH_17460	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
THITH_17465	COG1390	Produces ATP from ADP in the presence of a proton gradient across the membrane
THITH_17500	COG0706	membrane insertase activity
THITH_17505	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
THITH_17510	COG0594	ribonuclease P activity