locus-tag	class	description
TK90_0001	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
TK90_0002	COG0592	DNA-directed DNA polymerase activity
TK90_0003	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
TK90_0004	COG0187	DNA topoisomerase II activity
TK90_0006	COG0339	signal peptide processing
TK90_0007	COG0708	Exodeoxyribonuclease III
TK90_0008	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
TK90_0010	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
TK90_0010	COG0543	2 iron, 2 sulfur cluster binding
TK90_0011	COG1587	Uroporphyrinogen-III synthase
TK90_0012	COG0181	hydroxymethylbilane synthase activity
TK90_0014	COG0745	RESPONSE REGULATOR receiver
TK90_0014	COG2972	Histidine kinase
TK90_0015	COG0165	Argininosuccinate lyase
TK90_0017	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
TK90_0019	COG0659	secondary active sulfate transmembrane transporter activity
TK90_0021	COG4772	TonB-dependent receptor
TK90_0023	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
TK90_0025	COG1846	Transcriptional regulator
TK90_0028	COG1335	isochorismatase
TK90_0031	COG0540	Belongs to the ATCase OTCase family
TK90_0032	COG0367	asparagine synthase
TK90_0034	COG3706	GGDEF domain
TK90_0038	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
TK90_0039	COG1333	cytochrome c biogenesis protein
TK90_0041	COG0218	Necessary for normal cell division and for the maintenance of normal septation
TK90_0049	COG3852	Histidine kinase
TK90_0051	COG0167	dihydroorotate dehydrogenase activity
TK90_0052	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
TK90_0054	COG0205	6-phosphofructokinase activity
TK90_0055	COG0563	adenylate kinase activity
TK90_0057	COG3302	dmso reductase anchor subunit
TK90_0058	COG0437	4 iron, 4 sulfur cluster binding
TK90_0059	COG0243	molybdopterin cofactor binding
TK90_0062	COG2046	Belongs to the sulfate adenylyltransferase family
TK90_0067	COG1047	Peptidyl-prolyl cis-trans
TK90_0070	COG0708	Exodeoxyribonuclease III
TK90_0071	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
TK90_0076	COG3039	Transposase
TK90_0077	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
TK90_0079	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
TK90_0084	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
TK90_0085	COG0205	6-phosphofructokinase activity
TK90_0091	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
TK90_0092	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
TK90_0094	COG0268	Binds directly to 16S ribosomal RNA
TK90_0096	COG0210	DNA helicase
TK90_0097	COG0567	Dehydrogenase, E1 component
TK90_0098	COG0508	dehydrogenase complex catalyzes the overall conversion of
TK90_0100	COG3706	GGDEF domain
TK90_0100	COG0745	RESPONSE REGULATOR receiver
TK90_0101	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
TK90_0103	COG2226	methyltransferase
TK90_0115	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
TK90_0116	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
TK90_0117	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
TK90_0119	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
TK90_0120	COG4106	trans-aconitate 2-methyltransferase activity
TK90_0125	COG0131	Imidazoleglycerol-phosphate dehydratase
TK90_0126	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
TK90_0127	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
TK90_0128	COG0107	imidazoleglycerol-phosphate synthase activity
TK90_0129	COG0140	phosphoribosyl-ATP diphosphatase activity
TK90_0130	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
TK90_0131	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
TK90_0132	COG0805	protein transport
TK90_0133	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
TK90_0138	COG3706	GGDEF domain
TK90_0140	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
TK90_0141	COG1392	Phosphate transport regulator
TK90_0142	COG0306	phosphate transporter
TK90_0143	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
TK90_0144	COG0243	molybdopterin cofactor binding
TK90_0145	COG0437	4 iron, 4 sulfur cluster binding
TK90_0146	COG3302	dmso reductase anchor subunit
TK90_0154	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
TK90_0156	COG2267	carboxylic ester hydrolase activity
TK90_0157	COG2226	methyltransferase
TK90_0158	COG3278	Belongs to the heme-copper respiratory oxidase family
TK90_0162	COG0348	domain, Protein
TK90_0168	COG2177	Part of the ABC transporter FtsEX involved in
TK90_0169	COG2884	Cell division ATP-binding protein ftsE
TK90_0170	COG0552	protein localization to endoplasmic reticulum
TK90_0171	COG0612	Peptidase, M16
TK90_0172	COG0612	Peptidase, M16
TK90_0176	COG0058	SHG alpha-glucan phosphorylase activity
TK90_0177	COG0151	Belongs to the GarS family
TK90_0178	COG0138	bifunctional purine biosynthesis protein purh
TK90_0181	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
TK90_0182	COG0646	methionine synthase
TK90_0182	COG1410	methionine synthase
TK90_0185	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
TK90_0187	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
TK90_0191	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
TK90_0193	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
TK90_0196	COG0004	ammonium transporteR
TK90_0197	COG1116	anion transmembrane transporter activity
TK90_0198	COG0390	transport system, permease component
TK90_0201	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
TK90_0202	COG1166	arginine decarboxylase activity
TK90_0203	COG3100	YcgL domain-containing protein
TK90_0205	COG3744	PilT protein domain protein
TK90_0225	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
TK90_0227	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
TK90_0236	COG0446	pyridine nucleotide-disulphide oxidoreductase
TK90_0242	COG0745	RESPONSE REGULATOR receiver
TK90_0243	COG2205	protein histidine kinase activity
TK90_0244	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
TK90_0245	COG1643	Atp-dependent helicase
TK90_0247	COG0018	arginyl-trna synthetase
TK90_0248	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
TK90_0249	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
TK90_0250	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
TK90_0251	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
TK90_0253	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
TK90_0254	COG1546	Belongs to the CinA family
TK90_0254	COG1058	Belongs to the CinA family
TK90_0256	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
TK90_0263	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
TK90_0265	COG0069	glutamate synthase activity
TK90_0265	COG0070	glutamate synthase
TK90_0265	COG0067	glutamate synthase
TK90_0267	COG0232	Belongs to the dGTPase family. Type 2 subfamily
TK90_0268	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
TK90_0269	COG0828	Belongs to the bacterial ribosomal protein bS21 family
TK90_0271	COG0493	'glutamate synthase
TK90_0272	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
TK90_0280	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
TK90_0284	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
TK90_0285	COG4232	protein-disulfide reductase activity
TK90_0290	COG3030	protein affecting phage T7 exclusion by the F plasmid
TK90_0291	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
TK90_0292	COG0459	protein refolding
TK90_0293	COG2885	chlorophyll binding
TK90_0293	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
TK90_0295	COG2911	Protein conserved in bacteria
TK90_0296	COG0729	surface antigen
TK90_0297	COG3842	ATPase activity
TK90_0298	COG1178	ABC-type Fe3 transport system permease component
TK90_0299	COG1840	ABC-type Fe3 transport system, periplasmic component
TK90_0300	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
TK90_0303	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
TK90_0303	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
TK90_0304	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
TK90_0307	COG0859	PFAM glycosyl transferase family 9
TK90_0308	COG1560	Kdo2-lipid A biosynthetic process
TK90_0310	COG1132	(ABC) transporter
TK90_0313	COG0297	glycogen (starch) synthase activity
TK90_0319	COG0438	transferase activity, transferring glycosyl groups
TK90_0320	COG0859	PFAM glycosyl transferase family 9
TK90_0321	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
TK90_0322	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
TK90_0323	COG1519	Transferase
TK90_0324	COG3091	SprT-like family
TK90_0326	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
TK90_0328	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
TK90_0329	COG1792	Involved in formation and maintenance of cell shape
TK90_0330	COG1077	Cell shape determining protein MreB Mrl
TK90_0331	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
TK90_0332	COG0154	amidase activity
TK90_0333	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
TK90_0334	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
TK90_0339	COG2890	protein-(glutamine-N5) methyltransferase activity
TK90_0340	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
TK90_0341	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
TK90_0343	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
TK90_0344	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
TK90_0345	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
TK90_0346	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
TK90_0347	COG0193	aminoacyl-tRNA hydrolase activity
TK90_0348	COG0012	GTP binding
TK90_0349	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
TK90_0352	COG0508	dehydrogenase complex catalyzes the overall conversion of
TK90_0353	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
TK90_0355	COG0137	argininosuccinate synthase activity
TK90_0356	COG3706	GGDEF domain
TK90_0357	COG2853	Lipoprotein
TK90_0359	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
TK90_0362	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
TK90_0366	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
TK90_0369	COG1137	ATPase activity
TK90_0370	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
TK90_0374	COG1660	Displays ATPase and GTPase activities
TK90_0376	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
TK90_0377	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
TK90_0379	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
TK90_0380	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
TK90_0381	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
TK90_0383	COG2854	intermembrane phospholipid transfer
TK90_0384	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
TK90_0385	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
TK90_0386	COG1127	ABC transporter
TK90_0388	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
TK90_0390	COG0730	response to heat
TK90_0391	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
TK90_0392	COG0352	thiamine-phosphate diphosphorylase activity
TK90_0393	COG0352	thiamine-phosphate diphosphorylase activity
TK90_0393	COG0351	phosphomethylpyrimidine kinase
TK90_0396	COG0494	nUDIX hydrolase
TK90_0400	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
TK90_0403	COG0316	Belongs to the HesB IscA family
TK90_0404	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
TK90_0405	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
TK90_0408	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
TK90_0409	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
TK90_0410	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
TK90_0412	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
TK90_0413	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
TK90_0415	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
TK90_0416	COG0142	geranyltranstransferase activity
TK90_0417	COG1722	exodeoxyribonuclease VII activity
TK90_0418	COG1592	Rubrerythrin
TK90_0424	COG4536	flavin adenine dinucleotide binding
TK90_0425	COG4137	Cytochrome C assembly protein
TK90_0426	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
TK90_0427	COG0228	four-way junction DNA binding
TK90_0428	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
TK90_0429	COG0336	Belongs to the RNA methyltransferase TrmD family
TK90_0430	COG0335	large ribosomal subunit rRNA binding
TK90_0433	COG2010	Cytochrome c
TK90_0434	COG2010	Cytochrome c
TK90_0435	COG0326	Molecular chaperone. Has ATPase activity
TK90_0438	COG0811	peptide transport
TK90_0445	COG4771	TonB-dependent receptor
TK90_0453	COG2983	Belongs to the UPF0260 family
TK90_0456	COG0497	DNA recombination
TK90_0457	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
TK90_0458	COG1420	regulation of RNA biosynthetic process
TK90_0459	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
TK90_0460	COG0443	Heat shock 70 kDa protein
TK90_0461	COG0484	heat shock protein binding
TK90_0462	COG3706	GGDEF domain
TK90_0464	COG1509	lysine 2,3-aminomutase activity
TK90_0465	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
TK90_0466	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
TK90_0467	COG2027	D-alanyl-D-alanine carboxypeptidase
TK90_0472	COG1028	Short-chain dehydrogenase reductase Sdr
TK90_0475	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
TK90_0479	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
TK90_0482	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
TK90_0484	COG0525	valine-tRNA ligase activity
TK90_0485	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
TK90_0486	COG3012	SEC-C Motif Domain Protein
TK90_0489	COG5001	Diguanylate cyclase
TK90_0489	COG5002	protein histidine kinase activity
TK90_0491	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
TK90_0491	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
TK90_0492	COG0802	atpase or kinase
TK90_0493	COG0860	N-Acetylmuramoyl-L-alanine amidase
TK90_0494	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
TK90_0495	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
TK90_0496	COG1923	regulation of RNA biosynthetic process
TK90_0497	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
TK90_0498	COG1388	LysM domain
TK90_0498	COG0741	lytic transglycosylase activity
TK90_0500	COG0328	RNA-DNA hybrid ribonuclease activity
TK90_0501	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
TK90_0502	COG0471	metal ion transport
TK90_0502	COG3273	potassium ion transport
TK90_0503	COG0442	prolyl-tRNA aminoacylation
TK90_0506	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
TK90_0509	COG0700	Nucleoside recognition
TK90_0510	COG0300	oxidoreductase activity
TK90_0514	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
TK90_0520	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
TK90_0530	COG3300	MHYT domain
TK90_0530	COG5001	Diguanylate cyclase
TK90_0531	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
TK90_0535	COG0501	Belongs to the peptidase M48B family
TK90_0536	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
TK90_0541	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
TK90_0542	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
TK90_0545	COG0247	lactate metabolic process
TK90_0548	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
TK90_0549	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
TK90_0550	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
TK90_0552	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
TK90_0553	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
TK90_0555	COG0628	permease
TK90_0559	COG1393	Belongs to the ArsC family
TK90_0560	COG1254	Belongs to the acylphosphatase family
TK90_0561	COG2255	four-way junction helicase activity
TK90_0562	COG0824	Thioesterase
TK90_0566	COG0823	Involved in the tonB-independent uptake of proteins
TK90_0569	COG0602	queuosine metabolic process
TK90_0570	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
TK90_0571	COG2391	methyltransferase activity
TK90_0572	COG0544	peptidyl-prolyl cis-trans isomerase activity
TK90_0573	COG0740	serine-type endopeptidase activity
TK90_0574	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
TK90_0575	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
TK90_0578	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
TK90_0580	COG0840	transmembrane signaling receptor activity
TK90_0582	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
TK90_0587	COG2095	MarC family integral membrane protein
TK90_0590	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
TK90_0591	COG0811	peptide transport
TK90_0594	COG1663	tetraacyldisaccharide 4'-kinase activity
TK90_0595	COG2835	tetraacyldisaccharide 4'-kinase activity
TK90_0596	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
TK90_0597	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
TK90_0600	COG0601	transmembrane transport
TK90_0601	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
TK90_0602	COG4172	Belongs to the ABC transporter superfamily
TK90_0603	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
TK90_0604	COG3706	GGDEF domain
TK90_0609	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
TK90_0610	COG0438	transferase activity, transferring glycosyl groups
TK90_0611	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
TK90_0617	COG1132	(ABC) transporter
TK90_0622	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
TK90_0628	COG4783	chaperone-mediated protein folding
TK90_0630	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
TK90_0631	COG0425	Belongs to the sulfur carrier protein TusA family
TK90_0637	COG2048	Heterodisulfide reductase, subunit B
TK90_0638	COG0509	glycine decarboxylation via glycine cleavage system
TK90_0640	COG0509	glycine decarboxylation via glycine cleavage system
TK90_0642	COG0095	Lipoate-protein ligase
TK90_0644	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
TK90_0653	COG0123	including yeast histone deacetylase and acetoin utilization protein
TK90_0656	COG1160	GTP binding
TK90_0658	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
TK90_0664	COG3707	response regulator
TK90_0665	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
TK90_0666	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
TK90_0667	COG1116	anion transmembrane transporter activity
TK90_0668	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
TK90_0669	COG2146	nitrite reductase [NAD(P)H] activity
TK90_0670	COG0243	molybdopterin cofactor binding
TK90_0671	COG1648	precorrin-2 dehydrogenase activity
TK90_0671	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
TK90_0673	COG1022	Amp-dependent synthetase and ligase
TK90_0676	COG0215	cysteine-tRNA ligase activity
TK90_0677	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
TK90_0678	COG4251	negative regulation of phosphorylation
TK90_0679	COG0784	Response regulator, receiver
TK90_0682	COG0730	response to heat
TK90_0683	COG0523	cobalamin synthesis protein
TK90_0690	COG1131	(ABC) transporter
TK90_0693	COG2084	Dehydrogenase
TK90_0695	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
TK90_0698	COG0505	Belongs to the CarA family
TK90_0700	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
TK90_0701	COG1534	Rna-binding protein
TK90_0702	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
TK90_0703	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
TK90_0704	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
TK90_0705	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
TK90_0706	COG0149	triose-phosphate isomerase activity
TK90_0708	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
TK90_0709	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
TK90_0710	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
TK90_0711	COG0649	NAD binding
TK90_0715	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
TK90_0716	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
TK90_0718	COG0713	ATP synthesis coupled electron transport
TK90_0721	COG1007	ATP synthesis coupled electron transport
TK90_0723	COG0779	Required for maturation of 30S ribosomal subunits
TK90_0724	COG2251	uridine kinase activity
TK90_0724	COG0195	Participates in both transcription termination and antitermination
TK90_0725	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
TK90_0726	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
TK90_0727	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
TK90_0728	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
TK90_0729	COG1185	polyribonucleotide nucleotidyltransferase activity
TK90_0731	COG0105	UTP biosynthetic process
TK90_0732	COG0820	rRNA (adenine-C2-)-methyltransferase activity
TK90_0735	COG0124	histidyl-tRNA synthetase
TK90_0737	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
TK90_0738	COG1160	GTP binding
TK90_0739	COG0436	Aminotransferase
TK90_0741	COG0733	neurotransmitter:sodium symporter activity
TK90_0742	COG0033	Phosphoglucomutase
TK90_0744	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
TK90_0749	COG2111	Na H antiporter
TK90_0753	COG2212	antiporter activity
TK90_0754	COG1320	monovalent cation:proton antiporter activity
TK90_0756	COG0640	Transcriptional regulator
TK90_0757	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
TK90_0757	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
TK90_0761	COG1434	Gram-negative-bacterium-type cell wall biogenesis
TK90_0765	COG2353	YceI-like domain
TK90_0769	COG0438	transferase activity, transferring glycosyl groups
TK90_0776	COG2210	Belongs to the sulfur carrier protein TusA family
TK90_0782	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
TK90_0784	COG1193	negative regulation of DNA recombination
TK90_0787	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
TK90_0788	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
TK90_0790	COG4206	TonB-dependent receptor
TK90_0791	COG2096	Adenosyltransferase
TK90_0796	COG1797	cobyrinic acid a,c-diamide synthase activity
TK90_0797	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
TK90_0797	COG1648	precorrin-2 dehydrogenase activity
TK90_0798	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
TK90_0799	COG1131	(ABC) transporter
TK90_0800	COG0842	Transport permease protein
TK90_0814	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
TK90_0816	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
TK90_0816	COG1672	PFAM Archaeal ATPase
TK90_0820	COG0415	Belongs to the DNA photolyase family
TK90_0821	COG3046	protein related to deoxyribodipyrimidine photolyase
TK90_0822	COG0789	Transcriptional regulator
TK90_0823	COG1331	Highly conserved protein containing a thioredoxin domain
TK90_0828	COG1045	serine acetyltransferase
TK90_0830	COG1104	cysteine desulfurase activity
TK90_0831	COG0822	iron-sulfur transferase activity
TK90_0832	COG0316	Belongs to the HesB IscA family
TK90_0833	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
TK90_0834	COG0443	Heat shock 70 kDa protein
TK90_0837	COG5265	(ABC) transporter
TK90_0838	COG3706	GGDEF domain
TK90_0839	COG0514	ATP-dependent DNA helicase (RecQ)
TK90_0843	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
TK90_0849	COG4191	Histidine kinase
TK90_0851	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
TK90_0852	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
TK90_0853	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
TK90_0856	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
TK90_0857	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
TK90_0858	COG1850	ribulose-bisphosphate carboxylase activity
TK90_0859	COG4451	ribulose bisphosphate carboxylase, small
TK90_0867	COG2193	ferroxidase activity
TK90_0869	COG1192	Involved in chromosome partitioning
TK90_0873	COG0583	DNA-binding transcription factor activity
TK90_0877	COG0488	(ABC) transporter
TK90_0879	COG3002	Belongs to the UPF0753 family
TK90_0881	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
TK90_0884	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
TK90_0885	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
TK90_0886	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
TK90_0889	COG1965	Belongs to the frataxin family
TK90_0890	COG2363	Small membrane protein
TK90_0893	COG0742	ribosomal rna small subunit methyltransferase
TK90_0895	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
TK90_0900	COG2738	Putative neutral zinc metallopeptidase
TK90_0901	COG0668	transmembrane transport
TK90_0902	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
TK90_0906	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
TK90_0909	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
TK90_0910	COG0398	Pfam SNARE associated Golgi protein
TK90_0912	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
TK90_0914	COG0291	Belongs to the bacterial ribosomal protein bL35 family
TK90_0915	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
TK90_0916	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
TK90_0917	COG0072	phenylalanine-tRNA ligase activity
TK90_0917	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
TK90_0918	COG0776	regulation of translation
TK90_0920	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
TK90_0924	COG0784	Response regulator, receiver
TK90_0924	COG0835	chemotaxis
TK90_0925	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
TK90_0926	COG1815	bacterial-type flagellum-dependent cell motility
TK90_0927	COG1558	bacterial-type flagellum-dependent cell motility
TK90_0928	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
TK90_0929	COG1749	Flagellar hook protein flgE
TK90_0930	COG4787	bacterial-type flagellum-dependent cell motility
TK90_0931	COG4786	Flagellar basal body rod
TK90_0932	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
TK90_0933	COG1706	bacterial-type flagellum-dependent cell motility
TK90_0936	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
TK90_0940	COG0121	glutamine amidotransferase
TK90_0941	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
TK90_0942	COG2062	phosphohistidine phosphatase, SixA
TK90_0943	COG0248	Ppx GppA phosphatase
TK90_0944	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
TK90_0945	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
TK90_0946	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
TK90_0948	COG0471	metal ion transport
TK90_0949	COG0840	transmembrane signaling receptor activity
TK90_0953	COG0704	Plays a role in the regulation of phosphate uptake
TK90_0954	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
TK90_0955	COG0573	inorganic phosphate transmembrane transporter activity
TK90_0956	COG0573	inorganic phosphate transmembrane transporter activity
TK90_0961	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
TK90_0962	COG1116	anion transmembrane transporter activity
TK90_0962	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
TK90_0963	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
TK90_0964	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
TK90_0966	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
TK90_0967	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
TK90_0968	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
TK90_0968	COG1116	anion transmembrane transporter activity
TK90_0975	COG0739	heme binding
TK90_0975	COG0741	lytic transglycosylase activity
TK90_0975	COG1196	nuclear chromosome segregation
TK90_0977	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
TK90_0983	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
TK90_0987	COG4191	Histidine kinase
TK90_0989	COG2133	pyrroloquinoline quinone binding
TK90_0996	COG3706	GGDEF domain
TK90_0997	COG0277	FAD linked oxidase domain protein
TK90_0999	COG0651	ATP synthesis coupled electron transport
TK90_1000	COG0651	ATP synthesis coupled electron transport
TK90_1001	COG1007	ATP synthesis coupled electron transport
TK90_1004	COG1320	monovalent cation:proton antiporter activity
TK90_1009	COG0560	Phosphoserine phosphatase
TK90_1012	COG0392	lysyltransferase activity
TK90_1012	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
TK90_1013	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
TK90_1024	COG0322	excinuclease ABC activity
TK90_1026	COG5001	Diguanylate cyclase
TK90_1026	COG5002	protein histidine kinase activity
TK90_1028	COG0513	Belongs to the DEAD box helicase family
TK90_1030	COG1393	Belongs to the ArsC family
TK90_1031	COG2171	N-acyltransferase activity
TK90_1032	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
TK90_1035	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
TK90_1041	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
TK90_1043	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
TK90_1046	COG0513	Belongs to the DEAD box helicase family
TK90_1050	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
TK90_1052	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
TK90_1054	COG0251	oxidation-reduction process
TK90_1055	COG2226	methyltransferase
TK90_1056	COG1872	DUF167
TK90_1057	COG0418	dihydroorotase activity
TK90_1059	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
TK90_1064	COG1959	2 iron, 2 sulfur cluster binding
TK90_1065	COG1968	undecaprenyl-diphosphatase activity
TK90_1066	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
TK90_1067	COG4181	ATPase activity
TK90_1073	COG1704	LemA family
TK90_1074	COG0501	Belongs to the peptidase M48B family
TK90_1075	COG5001	Diguanylate cyclase
TK90_1077	COG0739	heme binding
TK90_1078	COG0842	Transport permease protein
TK90_1079	COG1131	(ABC) transporter
TK90_1080	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
TK90_1086	COG3047	cAMP biosynthetic process
TK90_1091	COG3706	GGDEF domain
TK90_1093	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
TK90_1094	COG0662	Cupin 2, conserved barrel domain protein
TK90_1094	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
TK90_1095	COG0587	DNA-directed DNA polymerase activity
TK90_1105	COG3093	addiction module antidote protein HigA
TK90_1107	COG2135	peptidase activity
TK90_1110	COG3039	Transposase
TK90_1119	COG0745	RESPONSE REGULATOR receiver
TK90_1119	COG3706	GGDEF domain
TK90_1120	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
TK90_1137	COG2963	transposase activity
TK90_1138	COG2801	Transposase and inactivated derivatives
TK90_1143	COG0582	viral genome integration into host DNA
TK90_1146	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
TK90_1148	COG1714	RDD family
TK90_1149	COG3588	fructose-bisphosphate aldolase
TK90_1150	COG0737	Belongs to the 5'-nucleotidase family
TK90_1151	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
TK90_1152	COG0432	Pfam Uncharacterised protein family UPF0047
TK90_1155	COG3604	Transcriptional regulator
TK90_1156	COG2204	response regulator
TK90_1163	COG3144	bacterial-type flagellum assembly
TK90_1170	COG1684	flagellar biosynthetic protein fliR
TK90_1174	COG0455	bacterial-type flagellum organization
TK90_1177	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
TK90_1178	COG0643	Histidine kinase
TK90_1178	COG2198	Histidine kinase
TK90_1179	COG2201	protein-glutamate methylesterase activity
TK90_1180	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
TK90_1181	COG1360	Flagellar Motor Protein
TK90_1182	COG1192	Involved in chromosome partitioning
TK90_1187	COG2257	FlhB HrpN YscU SpaS Family
TK90_1189	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
TK90_1190	COG1530	ribonuclease E activity
TK90_1192	COG0546	phosphoglycolate phosphatase activity
TK90_1193	COG0616	signal peptide processing
TK90_1195	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
TK90_1197	COG2957	Belongs to the agmatine deiminase family
TK90_1199	COG4591	ABC-type transport system involved in lipoprotein release permease component
TK90_1200	COG1136	(ABC) transporter
TK90_1202	COG2333	competence protein COMEC
TK90_1202	COG0658	competence protein
TK90_1203	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
TK90_1205	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
TK90_1206	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
TK90_1209	COG0287	Prephenate dehydrogenase
TK90_1210	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
TK90_1213	COG0776	regulation of translation
TK90_1216	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
TK90_1217	COG0284	orotidine-5'-phosphate decarboxylase activity
TK90_1218	COG1596	polysaccharide export
TK90_1218	COG1555	photosystem II stabilization
TK90_1219	COG1210	Utp--glucose-1-phosphate uridylyltransferase
TK90_1221	COG0129	dihydroxy-acid dehydratase activity
TK90_1224	COG0235	Class ii aldolase
TK90_1225	COG3909	cytochrome
TK90_1226	COG2010	Cytochrome c
TK90_1232	COG0305	Participates in initiation and elongation during chromosome replication
TK90_1243	COG1472	Belongs to the glycosyl hydrolase 3 family
TK90_1246	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
TK90_1253	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
TK90_1254	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
TK90_1255	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
TK90_1256	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
TK90_1257	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
TK90_1258	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
TK90_1261	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
TK90_1262	COG0542	response to heat
TK90_1263	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
TK90_1266	COG0482	sulfurtransferase activity
TK90_1267	COG2915	High frequency lysogenization protein hflD homolog
TK90_1274	COG2850	peptidyl-arginine hydroxylation
TK90_1275	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
TK90_1278	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
TK90_1279	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
TK90_1279	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
TK90_1280	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
TK90_1282	COG0436	Aminotransferase
TK90_1285	COG4942	peptidase
TK90_1286	COG1238	metal cluster binding
TK90_1287	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
TK90_1288	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
TK90_1289	COG1193	negative regulation of DNA recombination
TK90_1292	COG1366	Belongs to the anti-sigma-factor antagonist family
TK90_1293	COG0585	pseudouridine synthase activity
TK90_1295	COG1199	ATP-dependent helicase activity
TK90_1297	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
TK90_1300	COG0791	NLP P60 protein
TK90_1302	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
TK90_1303	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
TK90_1304	COG1862	Preprotein translocase
TK90_1305	COG0343	queuine tRNA-ribosyltransferase activity
TK90_1306	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
TK90_1314	COG3903	Transcriptional regulator
TK90_1314	COG2197	response regulator
TK90_1315	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
TK90_1317	COG0590	tRNA wobble adenosine to inosine editing
TK90_1318	COG0386	Belongs to the glutathione peroxidase family
TK90_1321	COG1127	ABC transporter
TK90_1322	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
TK90_1323	COG0714	Associated with various cellular activities
TK90_1327	COG1376	ErfK ybiS ycfS ynhG family protein
TK90_1329	COG1286	toxin biosynthetic process
TK90_1331	COG0285	dihydrofolate synthase activity
TK90_1332	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
TK90_1333	COG0159	tryptophan synthase activity
TK90_1334	COG0133	tryptophan synthase activity
TK90_1336	COG0135	phosphoribosylanthranilate isomerase activity
TK90_1337	COG0101	tRNA pseudouridine synthase activity
TK90_1340	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
TK90_1341	COG0473	3-isopropylmalate dehydrogenase activity
TK90_1343	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
TK90_1347	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
TK90_1348	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
TK90_1356	COG3706	GGDEF domain
TK90_1357	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
TK90_1358	COG0133	tryptophan synthase activity
TK90_1359	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
TK90_1360	COG0123	including yeast histone deacetylase and acetoin utilization protein
TK90_1369	COG1446	asparaginase
TK90_1370	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
TK90_1372	COG3706	GGDEF domain
TK90_1379	COG0604	alcohol dehydrogenase
TK90_1381	COG3272	Protein of unknown function (DUF1722)
TK90_1382	COG1752	Esterase of the alpha-beta hydrolase superfamily
TK90_1386	COG3047	cAMP biosynthetic process
TK90_1386	COG2885	chlorophyll binding
TK90_1387	COG3706	GGDEF domain
TK90_1391	COG3237	CsbD-like
TK90_1396	COG1620	l-lactate permease
TK90_1403	COG2203	Gaf domain
TK90_1403	COG2200	EAL domain
TK90_1403	COG2199	diguanylate cyclase activity
TK90_1408	COG2249	NAD(P)H dehydrogenase (quinone) activity
TK90_1412	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
TK90_1419	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
TK90_1420	COG0537	adenosine 5'-monophosphoramidase activity
TK90_1422	COG2863	cytochrome
TK90_1425	COG2203	Gaf domain
TK90_1425	COG5001	Diguanylate cyclase
TK90_1425	COG3706	GGDEF domain
TK90_1425	COG4251	negative regulation of phosphorylation
TK90_1426	COG3706	GGDEF domain
TK90_1427	COG0477	Major facilitator Superfamily
TK90_1441	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
TK90_1442	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
TK90_1442	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
TK90_1443	COG0492	ferredoxin-NADP+ reductase activity
TK90_1446	COG1516	flagellar protein fliS
TK90_1449	COG1334	flagellar protein FlaG
TK90_1452	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
TK90_1454	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
TK90_1456	COG1492	cobalamin metabolic process
TK90_1458	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
TK90_1459	COG0778	Nitroreductase
TK90_1460	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
TK90_1461	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
TK90_1462	COG1120	ATPase activity
TK90_1464	COG1741	Belongs to the pirin family
TK90_1465	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
TK90_1467	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
TK90_1468	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
TK90_1469	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
TK90_1470	COG0148	phosphopyruvate hydratase activity
TK90_1471	COG2877	3-deoxy-8-phosphooctulonate synthase activity
TK90_1472	COG0504	CTP synthase activity
TK90_1474	COG3706	GGDEF domain
TK90_1478	COG0037	tRNA processing
TK90_1479	COG0825	malonyl-CoA metabolic process
TK90_1481	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
TK90_1482	COG0673	inositol 2-dehydrogenase activity
TK90_1484	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
TK90_1485	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
TK90_1486	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
TK90_1489	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
TK90_1492	COG0575	Belongs to the CDS family
TK90_1493	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
TK90_1494	COG0233	cytoplasmic translational termination
TK90_1495	COG0528	UMP kinase activity
TK90_1496	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
TK90_1497	COG0052	Belongs to the universal ribosomal protein uS2 family
TK90_1498	COG0024	Methionine aminopeptidase
TK90_1499	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
TK90_1504	COG5001	Diguanylate cyclase
TK90_1505	COG0655	NAD(P)H dehydrogenase (quinone) activity
TK90_1506	COG0402	S-adenosylhomocysteine deaminase activity
TK90_1507	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
TK90_1509	COG1322	Protein conserved in bacteria
TK90_1510	COG1562	ergosterol biosynthetic process
TK90_1512	COG1562	ergosterol biosynthetic process
TK90_1513	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
TK90_1518	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
TK90_1518	COG0069	glutamate synthase activity
TK90_1519	COG0259	pyridoxamine-phosphate oxidase activity
TK90_1521	COG3795	YCII-related domain
TK90_1525	COG5507	3-demethylubiquinone-9 3-methyltransferase
TK90_1526	COG4941	Belongs to the sigma-70 factor family
TK90_1529	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
TK90_1530	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
TK90_1533	COG1487	ribonuclease activity
TK90_1539	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
TK90_1549	COG1216	Glycosyl transferase, family 2
TK90_1550	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
TK90_1561	COG3039	Transposase
TK90_1575	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
TK90_1577	COG1196	nuclear chromosome segregation
TK90_1578	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
TK90_1579	COG1070	Carbohydrate kinase
TK90_1581	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
TK90_1584	COG2208	phosphoserine phosphatase activity
TK90_1584	COG2770	Histidine kinase
TK90_1586	COG2146	nitrite reductase [NAD(P)H] activity
TK90_1589	COG1671	Belongs to the UPF0178 family
TK90_1591	COG0455	bacterial-type flagellum organization
TK90_1592	COG4191	Histidine kinase
TK90_1596	COG2610	gluconate transmembrane transporter activity
TK90_1597	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
TK90_1598	COG0322	excinuclease ABC activity
TK90_1599	COG1573	uracil-dna glycosylase
TK90_1601	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
TK90_1602	COG0416	fatty acid biosynthetic process
TK90_1603	COG0333	Belongs to the bacterial ribosomal protein bL32 family
TK90_1605	COG0439	Biotin carboxylase
TK90_1606	COG5016	pyruvate
TK90_1606	COG0511	ligase activity, forming carbon-carbon bonds
TK90_1607	COG0424	maF-like protein
TK90_1608	COG0640	Transcriptional regulator
TK90_1612	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
TK90_1613	COG0527	aspartate kinase activity
TK90_1614	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
TK90_1616	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
TK90_1617	COG1546	Belongs to the CinA family
TK90_1619	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
TK90_1623	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
TK90_1624	COG1074	ATP-dependent DNA helicase activity
TK90_1625	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
TK90_1626	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
TK90_1629	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
TK90_1633	COG3093	addiction module antidote protein HigA
TK90_1642	COG0469	pyruvate kinase activity
TK90_1645	COG3273	potassium ion transport
TK90_1645	COG0471	metal ion transport
TK90_1648	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
TK90_1650	COG2814	Major facilitator Superfamily
TK90_1655	COG1970	mechanosensitive ion channel activity
TK90_1658	COG0494	nUDIX hydrolase
TK90_1663	COG3706	GGDEF domain
TK90_1667	COG5002	protein histidine kinase activity
TK90_1667	COG5001	Diguanylate cyclase
TK90_1668	COG1403	HNH endonuclease
TK90_1676	COG2308	Evidence 4 Homologs of previously reported genes of
TK90_1678	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
TK90_1681	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
TK90_1683	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
TK90_1685	COG1943	Transposase
TK90_1689	COG1136	(ABC) transporter
TK90_1690	COG2239	Acts as a magnesium transporter
TK90_1691	COG2239	Acts as a magnesium transporter
TK90_1708	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
TK90_1709	COG1522	sequence-specific DNA binding
TK90_1710	COG1108	ABC-type Mn2 Zn2 transport systems permease components
TK90_1711	COG1121	(ABC) transporter
TK90_1712	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
TK90_1714	COG3706	GGDEF domain
TK90_1715	COG3706	GGDEF domain
TK90_1716	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
TK90_1717	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
TK90_1718	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
TK90_1719	COG0509	glycine decarboxylation via glycine cleavage system
TK90_1720	COG0404	The glycine cleavage system catalyzes the degradation of glycine
TK90_1722	COG1115	amino acid carrier protein
TK90_1724	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
TK90_1725	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
TK90_1726	COG0180	Tryptophanyl-tRNA synthetase
TK90_1728	COG0009	L-threonylcarbamoyladenylate synthase
TK90_1729	COG2350	Protein conserved in bacteria
TK90_1730	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
TK90_1735	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
TK90_1740	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
TK90_1743	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
TK90_1744	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
TK90_1746	COG0509	glycine decarboxylation via glycine cleavage system
TK90_1750	COG3706	GGDEF domain
TK90_1753	COG1187	pseudouridine synthase activity
TK90_1754	COG0521	Mo-molybdopterin cofactor biosynthetic process
TK90_1757	COG0583	DNA-binding transcription factor activity
TK90_1759	COG0616	signal peptide processing
TK90_1765	COG0189	ligase activity
TK90_1765	COG4067	protein conserved in archaea
TK90_1766	COG0189	ligase activity
TK90_1768	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
TK90_1770	COG3038	cytochrome b561
TK90_1771	COG1011	Hydrolase
TK90_1774	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
TK90_1776	COG0456	acetyltransferase
TK90_1777	COG1573	uracil-dna glycosylase
TK90_1778	COG1183	phosphatidylcholine synthase activity
TK90_1779	COG0688	phosphatidylethanolamine metabolic process
TK90_1780	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
TK90_1781	COG0440	acetolactate synthase activity
TK90_1782	COG0028	Belongs to the TPP enzyme family
TK90_1784	COG0549	Belongs to the carbamate kinase family
TK90_1785	COG0717	Belongs to the dCTP deaminase family
TK90_1786	COG0489	protein tyrosine kinase activity
TK90_1787	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
TK90_1787	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
TK90_1790	COG4657	Part of a membrane complex involved in electron transport
TK90_1791	COG2878	Part of a membrane complex involved in electron transport
TK90_1795	COG4660	Part of a membrane complex involved in electron transport
TK90_1798	COG2233	PERMEase
TK90_1801	COG0386	Belongs to the glutathione peroxidase family
TK90_1819	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
TK90_1820	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
TK90_1821	COG0006	proline dipeptidase activity
TK90_1826	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
TK90_1827	COG1674	ftsk spoiiie
TK90_1831	COG3263	regulation of cellular component size
TK90_1832	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
TK90_1833	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
TK90_1836	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
TK90_1837	COG2894	cell division
TK90_1838	COG0850	regulation of cytokinetic process
TK90_1840	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
TK90_1844	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
TK90_1846	COG0688	phosphatidylethanolamine metabolic process
TK90_1847	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
TK90_1849	COG2154	pterin-4-alpha-carbinolamine dehydratase
TK90_1850	COG1162	GTPase activity
TK90_1852	COG0537	adenosine 5'-monophosphoramidase activity
TK90_1853	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
TK90_1854	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
TK90_1856	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
TK90_1856	COG0678	peroxiredoxin activity
TK90_1860	COG3237	CsbD-like
TK90_1861	COG5487	UPF0391 membrane protein
TK90_1865	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
TK90_1868	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
TK90_1873	COG1366	Belongs to the anti-sigma-factor antagonist family
TK90_1876	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
TK90_1877	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
TK90_1878	COG1053	succinate dehydrogenase
TK90_1879	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
TK90_1883	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
TK90_1885	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
TK90_1885	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
TK90_1886	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
TK90_1887	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
TK90_1893	COG0277	FAD linked oxidase domain protein
TK90_1894	COG0247	lactate metabolic process
TK90_1895	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
TK90_1902	COG1331	Highly conserved protein containing a thioredoxin domain
TK90_1903	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
TK90_1904	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
TK90_1906	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
TK90_1912	COG0518	GMP synthase (glutamine-hydrolyzing) activity
TK90_1912	COG0519	Catalyzes the synthesis of GMP from XMP
TK90_1913	COG0516	GMP reductase activity
TK90_1913	COG0517	IMP dehydrogenase activity
TK90_1915	COG1570	exodeoxyribonuclease VII activity
TK90_1916	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
TK90_1917	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
TK90_1918	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
TK90_1922	COG1309	transcriptional regulator
TK90_1923	COG2833	Protein of unknown function (DUF455)
TK90_1925	COG2217	Heavy metal translocating P-type atpase
TK90_1928	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
TK90_1930	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
TK90_1931	COG0305	Participates in initiation and elongation during chromosome replication
TK90_1932	COG0359	binds to the 23S rRNA
TK90_1934	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
TK90_1935	COG0360	Binds together with S18 to 16S ribosomal RNA
TK90_1937	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
TK90_1938	COG0557	exoribonuclease II activity
TK90_1939	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
TK90_1940	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
TK90_1941	COG0330	HflC and HflK could
TK90_1942	COG0330	HflC and HflK could
TK90_1943	COG0736	holo-[acyl-carrier-protein] synthase activity
TK90_1944	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
TK90_1945	COG1381	Involved in DNA repair and RecF pathway recombination
TK90_1947	COG0571	ribonuclease III activity
TK90_1950	COG0481	GTPase activity
TK90_1952	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
TK90_1958	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
TK90_1958	COG1017	nitric oxide dioxygenase activity
TK90_1959	COG3956	TIGRFAM MazG family protein
TK90_1960	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
TK90_1960	COG3453	Protein conserved in bacteria
TK90_1966	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
TK90_1967	COG0321	lipoyl(octanoyl) transferase activity
TK90_1968	COG2921	Belongs to the UPF0250 family
TK90_1970	COG1686	Belongs to the peptidase S11 family
TK90_1972	COG2951	lytic endotransglycosylase activity
TK90_1973	COG0772	Belongs to the SEDS family
TK90_1974	COG0768	penicillin binding
TK90_1975	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
TK90_1976	COG0563	adenylate kinase activity
TK90_1977	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
TK90_1978	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
TK90_1979	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
TK90_1980	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
TK90_1982	COG2967	ApaG domain
TK90_1983	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
TK90_1984	COG0312	modulator of DNA gyrase
TK90_1986	COG0312	modulator of DNA gyrase
TK90_1987	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
TK90_1989	COG1530	ribonuclease E activity
TK90_1995	COG0227	Belongs to the bacterial ribosomal protein bL28 family
TK90_1996	COG0267	Belongs to the bacterial ribosomal protein bL33 family
TK90_1998	COG4251	negative regulation of phosphorylation
TK90_1998	COG3706	GGDEF domain
TK90_1998	COG5001	Diguanylate cyclase
TK90_1998	COG2203	Gaf domain
TK90_2000	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
TK90_2001	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
TK90_2002	COG1758	RNA polymerase activity
TK90_2003	COG0194	GDP metabolic process
TK90_2004	COG0142	geranyltranstransferase activity
TK90_2005	COG0261	This protein binds to 23S rRNA in the presence of protein L20
TK90_2006	COG0211	Belongs to the bacterial ribosomal protein bL27 family
TK90_2007	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
TK90_2008	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
TK90_2010	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
TK90_2011	COG2261	transglycosylase associated protein
TK90_2016	COG0632	four-way junction helicase activity
TK90_2017	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
TK90_2018	COG0217	transcriptional regulatory protein
TK90_2020	COG0793	Belongs to the peptidase S41A family
TK90_2021	COG4942	peptidase
TK90_2022	COG0640	Transcriptional regulator
TK90_2025	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
TK90_2026	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
TK90_2032	COG0542	response to heat
TK90_2034	COG0564	pseudouridine synthase activity
TK90_2036	COG0347	Belongs to the P(II) protein family
TK90_2038	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
TK90_2038	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
TK90_2039	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
TK90_2040	COG0045	succinate-CoA ligase (ADP-forming) activity
TK90_2041	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
TK90_2042	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
TK90_2043	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
TK90_2044	COG1428	Deoxynucleoside kinase
TK90_2047	COG0494	nUDIX hydrolase
TK90_2048	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
TK90_2050	COG0735	belongs to the Fur family
TK90_2051	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
TK90_2052	COG2914	Belongs to the UPF0125 (RnfH) family
TK90_2053	COG2867	negative regulation of translational initiation
TK90_2054	COG0733	neurotransmitter:sodium symporter activity
TK90_2055	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
TK90_2059	COG0628	permease
TK90_2061	COG1643	Atp-dependent helicase
TK90_2074	COG0598	Magnesium transport protein CorA
TK90_2075	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
TK90_2079	COG2095	MarC family integral membrane protein
TK90_2085	COG0583	DNA-binding transcription factor activity
TK90_2086	COG2259	Doxx family
TK90_2089	COG1741	Belongs to the pirin family
TK90_2092	COG4783	chaperone-mediated protein folding
TK90_2094	COG1902	pentaerythritol trinitrate reductase activity
TK90_2102	COG3118	belongs to the thioredoxin family
TK90_2107	COG0746	molybdenum cofactor guanylyltransferase activity
TK90_2108	COG1763	Mo-molybdopterin cofactor biosynthetic process
TK90_2109	COG0303	'Molybdopterin
TK90_2114	COG0795	lipopolysaccharide-transporting ATPase activity
TK90_2115	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
TK90_2119	COG0166	Belongs to the GPI family
TK90_2120	COG0297	glycogen (starch) synthase activity
TK90_2121	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
TK90_2125	COG0424	maF-like protein
TK90_2126	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
TK90_2128	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
TK90_2129	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
TK90_2132	COG0495	leucyl-tRNA aminoacylation
TK90_2135	COG0815	Transfers the fatty acyl group on membrane lipoproteins
TK90_2136	COG4535	Mg2 and Co2 transporter CorC
TK90_2137	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
TK90_2138	COG1702	phosphate starvation-inducible protein PhoH
TK90_2139	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
TK90_2141	COG2814	Major facilitator Superfamily
TK90_2143	COG0203	ribosomal protein L17
TK90_2144	COG0202	RNA polymerase activity
TK90_2145	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
TK90_2146	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
TK90_2147	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
TK90_2148	COG0257	Belongs to the bacterial ribosomal protein bL36 family
TK90_2149	COG0201	protein transport
TK90_2150	COG0200	Binds to the 23S rRNA
TK90_2151	COG1841	ribosomal large subunit assembly
TK90_2152	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
TK90_2153	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
TK90_2154	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
TK90_2155	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
TK90_2156	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
TK90_2157	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
TK90_2158	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
TK90_2159	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
TK90_2160	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
TK90_2161	COG0255	Belongs to the universal ribosomal protein uL29 family
TK90_2162	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
TK90_2163	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
TK90_2164	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
TK90_2165	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
TK90_2166	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
TK90_2167	COG0089	rRNA binding
TK90_2168	COG0088	Forms part of the polypeptide exit tunnel
TK90_2169	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
TK90_2170	COG0051	transcription antitermination factor activity, RNA binding
TK90_2171	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
TK90_2172	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
TK90_2173	COG0049	tRNA binding
TK90_2174	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
TK90_2175	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
TK90_2176	COG0085	RNA polymerase activity
TK90_2177	COG0222	ribosome binding
TK90_2178	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
TK90_2179	COG0081	regulation of translation
TK90_2180	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
TK90_2182	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
TK90_2183	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
TK90_2187	COG0237	dephospho-CoA kinase activity
TK90_2188	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
TK90_2189	COG0494	nUDIX hydrolase
TK90_2190	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
TK90_2191	COG0653	protein targeting
TK90_2194	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
TK90_2195	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
TK90_2197	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
TK90_2198	COG1181	Belongs to the D-alanine--D-alanine ligase family
TK90_2199	COG0812	UDP-N-acetylmuramate dehydrogenase activity
TK90_2200	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
TK90_2201	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
TK90_2202	COG0772	Belongs to the SEDS family
TK90_2203	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
TK90_2204	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
TK90_2205	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
TK90_2206	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
TK90_2208	COG3116	cell division
TK90_2209	COG0275	rRNA processing
TK90_2210	COG2001	Belongs to the MraZ family
TK90_2211	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
TK90_2212	COG3107	peptidoglycan biosynthetic process
TK90_2213	COG0792	nuclease activity
TK90_2214	COG0277	FAD linked oxidase domain protein
TK90_2215	COG2969	positive regulation of protein catabolic process
TK90_2216	COG0625	glutathione transferase activity
TK90_2217	COG2857	Cytochrome c1
TK90_2218	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
TK90_2219	COG0723	plastoquinol--plastocyanin reductase activity
TK90_2221	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
TK90_2227	COG0308	aminopeptidase N
TK90_2228	COG0084	hydrolase, TatD family'
TK90_2231	COG4737	Cytotoxic translational repressor of toxin-antitoxin stability system
TK90_2232	COG0189	ligase activity
TK90_2237	COG0271	Belongs to the BolA IbaG family
TK90_2240	COG1201	RNA secondary structure unwinding
TK90_2242	COG0511	ligase activity, forming carbon-carbon bonds
TK90_2243	COG0439	Biotin carboxylase
TK90_2244	COG2264	protein methyltransferase activity
TK90_2246	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
TK90_2248	COG0483	inositol monophosphate 1-phosphatase activity
TK90_2254	COG0210	DNA helicase
TK90_2259	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
TK90_2260	COG0756	dUTP diphosphatase activity
TK90_2261	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
TK90_2262	COG2133	pyrroloquinoline quinone binding
TK90_2264	COG1560	Kdo2-lipid A biosynthetic process
TK90_2266	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
TK90_2267	COG0569	domain protein
TK90_2268	COG2204	response regulator
TK90_2269	COG5000	phosphorelay sensor kinase activity
TK90_2271	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
TK90_2272	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
TK90_2273	COG0242	peptide deformylase activity
TK90_2275	COG0758	DNA mediated transformation
TK90_2276	COG2922	Belongs to the Smg family
TK90_2279	COG0408	coproporphyrinogen oxidase activity
TK90_2281	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
TK90_2282	COG2885	chlorophyll binding
TK90_2283	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
TK90_2284	COG1040	competence protein
TK90_2286	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
TK90_2288	COG0156	8-amino-7-oxononanoate synthase activity
TK90_2290	COG2311	Membrane
TK90_2291	COG2003	Belongs to the UPF0758 family
TK90_2292	COG0129	dihydroxy-acid dehydratase activity
TK90_2295	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
TK90_2295	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
TK90_2297	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
TK90_2298	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
TK90_2299	COG3178	'Phosphotransferase
TK90_2300	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
TK90_2311	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
TK90_2312	COG0438	transferase activity, transferring glycosyl groups
TK90_2318	COG5001	Diguanylate cyclase
TK90_2319	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
TK90_2320	COG2814	Major facilitator Superfamily
TK90_2321	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
TK90_2322	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
TK90_2323	COG0435	Glutathione S-transferase
TK90_2324	COG2918	glutathione biosynthetic process
TK90_2325	COG3527	Alpha-acetolactate decarboxylase
TK90_2327	COG2890	protein-(glutamine-N5) methyltransferase activity
TK90_2338	COG0488	(ABC) transporter
TK90_2339	COG0745	RESPONSE REGULATOR receiver
TK90_2339	COG3706	GGDEF domain
TK90_2340	COG0583	DNA-binding transcription factor activity
TK90_2342	COG0483	inositol monophosphate 1-phosphatase activity
TK90_2351	COG4566	intracellular signal transduction
TK90_2352	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
TK90_2352	COG3153	acetyltransferase
TK90_2355	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
TK90_2356	COG1765	OsmC-like protein
TK90_2358	COG0134	indole-3-glycerol-phosphate synthase activity
TK90_2359	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
TK90_2360	COG2814	Major facilitator Superfamily
TK90_2362	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
TK90_2363	COG0546	phosphoglycolate phosphatase activity
TK90_2367	COG2813	Specifically methylates the guanine in position
TK90_2368	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
TK90_2369	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
TK90_2373	COG0741	lytic transglycosylase activity
TK90_2377	COG0039	L-malate dehydrogenase activity
TK90_2378	COG0281	malic enzyme
TK90_2379	COG4783	chaperone-mediated protein folding
TK90_2381	COG0254	rRNA binding
TK90_2382	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
TK90_2383	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
TK90_2384	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
TK90_2386	COG0191	fructose-bisphosphate aldolase activity
TK90_2387	COG0469	pyruvate kinase activity
TK90_2388	COG0126	phosphoglycerate kinase activity
TK90_2389	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
TK90_2390	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
TK90_2391	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
TK90_2392	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
TK90_2393	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
TK90_2394	COG1385	rRNA (uridine-N3-)-methyltransferase activity
TK90_2398	COG0835	chemotaxis
TK90_2401	COG0189	ligase activity
TK90_2406	COG1678	Uncharacterized ACR, COG1678
TK90_2407	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
TK90_2409	COG0540	Belongs to the ATCase OTCase family
TK90_2411	COG0543	2 iron, 2 sulfur cluster binding
TK90_2418	COG0494	nUDIX hydrolase
TK90_2420	COG1011	Hydrolase
TK90_2422	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
TK90_2427	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
TK90_2428	COG0574	Belongs to the PEP-utilizing enzyme family
TK90_2428	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
TK90_2429	COG0189	ligase activity
TK90_2429	COG4067	protein conserved in archaea
TK90_2432	COG0735	belongs to the Fur family
TK90_2436	COG1121	(ABC) transporter
TK90_2439	COG1469	GTP cyclohydrolase I activity
TK90_2440	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
TK90_2441	COG0523	cobalamin synthesis protein
TK90_2453	COG1012	belongs to the aldehyde dehydrogenase family
TK90_2454	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
TK90_2455	COG0617	tRNA 3'-terminal CCA addition
TK90_2456	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
TK90_2457	COG1538	Outer membrane efflux protein
TK90_2461	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
TK90_2463	COG0220	tRNA (guanine-N7-)-methyltransferase activity
TK90_2464	COG2022	thiamine diphosphate biosynthetic process
TK90_2467	COG0513	Belongs to the DEAD box helicase family
TK90_2469	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
TK90_2472	COG0635	Involved in the biosynthesis of porphyrin-containing compound
TK90_2473	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
TK90_2474	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
TK90_2475	COG1561	YicC-like family, N-terminal region
TK90_2477	COG0071	Belongs to the small heat shock protein (HSP20) family
TK90_2479	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
TK90_2481	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
TK90_2482	COG0315	cyclic pyranopterin monophosphate synthase activity
TK90_2485	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
TK90_2491	COG0494	nUDIX hydrolase
TK90_2492	COG1061	Type III restriction enzyme res subunit
TK90_2496	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
TK90_2497	COG4191	Histidine kinase
TK90_2498	COG2204	response regulator
TK90_2500	COG2226	methyltransferase
TK90_2507	COG0489	protein tyrosine kinase activity
TK90_2509	COG3409	Peptidoglycan-binding domain 1 protein
TK90_2509	COG3267	Type II secretory pathway component ExeA
TK90_2515	COG0367	asparagine synthase
TK90_2517	COG0438	transferase activity, transferring glycosyl groups
TK90_2518	COG0438	transferase activity, transferring glycosyl groups
TK90_2521	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
TK90_2524	COG1215	transferase activity, transferring glycosyl groups
TK90_2527	COG1132	(ABC) transporter
TK90_2529	COG0318	PFAM AMP-dependent synthetase and ligase
TK90_2543	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
TK90_2546	COG2226	methyltransferase
TK90_2551	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
TK90_2552	COG0788	formyltetrahydrofolate deformylase activity
TK90_2553	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
TK90_2554	COG1047	Peptidyl-prolyl cis-trans
TK90_2556	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
TK90_2557	COG0196	riboflavin kinase activity
TK90_2559	COG1278	Cold shock
TK90_2561	COG1444	tRNA N-acetyltransferase activity
TK90_2562	COG0840	transmembrane signaling receptor activity
TK90_2564	COG0589	response to stress
TK90_2565	COG0471	metal ion transport
TK90_2565	COG3273	potassium ion transport
TK90_2569	COG0667	Aldo Keto reductase
TK90_2570	COG0084	hydrolase, TatD family'
TK90_2571	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
TK90_2574	COG0751	glycine-tRNA ligase activity
TK90_2575	COG0752	glycyl-tRNA synthetase alpha subunit
TK90_2576	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
TK90_2577	COG0174	glutamine synthetase
TK90_2579	COG0037	tRNA processing
TK90_2582	COG1490	D-aminoacyl-tRNA deacylase activity
TK90_2585	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
TK90_2586	COG0355	proton-transporting ATP synthase activity, rotational mechanism
TK90_2587	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
TK90_2588	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
TK90_2589	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
TK90_2590	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
TK90_2591	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
TK90_2593	COG0356	it plays a direct role in the translocation of protons across the membrane
TK90_2595	COG1475	DNA binding
TK90_2596	COG1192	Involved in chromosome partitioning
TK90_2597	COG0357	Ribosomal RNA small subunit methyltransferase G
TK90_2598	COG0445	tRNA wobble uridine modification
TK90_2599	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
TK90_2600	COG0706	membrane insertase activity
TK90_2601	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
TK90_2602	COG0594	ribonuclease P activity
TK90_2603	COG0230	Belongs to the bacterial ribosomal protein bL34 family
TK90_2647	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
TK90_2665	COG1555	photosystem II stabilization
TK90_2665	COG3568	Endonuclease Exonuclease Phosphatase
TK90_2687	COG5002	protein histidine kinase activity
TK90_2687	COG5001	Diguanylate cyclase
TK90_2717	COG0756	dUTP diphosphatase activity
TK90_2753	COG1404	Belongs to the peptidase S8 family
TK90_2756	COG0330	HflC and HflK could
TK90_2768	COG0187	DNA topoisomerase II activity
TK90_2775	COG1475	DNA binding
TK90_2779	COG1278	Cold shock
TK90_2792	COG1061	Type III restriction enzyme res subunit
TK90_2806	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
TK90_2808	COG2205	protein histidine kinase activity
TK90_2811	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
TK90_2811	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
TK90_2813	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
TK90_2817	COG4962	Type ii secretion system protein e
TK90_2827	COG0741	lytic transglycosylase activity
TK90_2833	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
TK90_2840	COG4974	Belongs to the 'phage' integrase family
TK90_2844	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
TK90_2848	COG0210	DNA helicase
TK90_2855	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
TK90_2866	COG3706	GGDEF domain
TK90_2879	COG1192	Involved in chromosome partitioning
TK90_2880	COG1475	DNA binding