locus-tag	class	description
TVD_00005	COG0751	glycine-tRNA ligase activity
TVD_00010	COG0204	Acyl-transferase
TVD_00020	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
TVD_00025	COG0084	hydrolase, TatD family'
TVD_00030	COG0667	Aldo Keto reductase
TVD_00050	COG3273	potassium ion transport
TVD_00050	COG0471	metal ion transport
TVD_00055	COG0589	response to stress
TVD_00060	COG0220	tRNA (guanine-N7-)-methyltransferase activity
TVD_00065	COG2022	thiamine diphosphate biosynthetic process
TVD_00100	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
TVD_00115	COG0635	Involved in the biosynthesis of porphyrin-containing compound
TVD_00120	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
TVD_00125	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
TVD_00130	COG1561	YicC-like family, N-terminal region
TVD_00140	COG0071	Belongs to the small heat shock protein (HSP20) family
TVD_00150	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
TVD_00160	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
TVD_00165	COG0315	cyclic pyranopterin monophosphate synthase activity
TVD_00175	COG1194	a g-specific adenine glycosylase
TVD_00180	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
TVD_00210	COG0494	nUDIX hydrolase
TVD_00215	COG1061	Type III restriction enzyme res subunit
TVD_00235	COG1434	Gram-negative-bacterium-type cell wall biogenesis
TVD_00245	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
TVD_00250	COG2205	protein histidine kinase activity
TVD_00255	COG2204	response regulator
TVD_00310	COG0489	protein tyrosine kinase activity
TVD_00320	COG3409	Peptidoglycan-binding domain 1 protein
TVD_00320	COG3267	Type II secretory pathway component ExeA
TVD_00350	COG0438	transferase activity, transferring glycosyl groups
TVD_00355	COG0367	asparagine synthase
TVD_00360	COG0438	transferase activity, transferring glycosyl groups
TVD_00365	COG0438	transferase activity, transferring glycosyl groups
TVD_00375	COG3093	addiction module antidote protein HigA
TVD_00380	COG3549	Plasmid maintenance system killer
TVD_00405	COG0463	Glycosyl transferase, family 2
TVD_00420	COG1132	(ABC) transporter
TVD_00430	COG2327	Polysaccharide pyruvyl transferase
TVD_00435	COG0463	Glycosyl transferase, family 2
TVD_00450	COG0318	PFAM AMP-dependent synthetase and ligase
TVD_00495	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
TVD_00550	COG0788	formyltetrahydrofolate deformylase activity
TVD_00555	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
TVD_00560	COG1047	Peptidyl-prolyl cis-trans
TVD_00565	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
TVD_00570	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
TVD_00575	COG0196	riboflavin kinase activity
TVD_00580	COG0728	peptidoglycan biosynthetic process
TVD_00585	COG1278	Cold shock
TVD_00600	COG3706	GGDEF domain
TVD_00600	COG0745	RESPONSE REGULATOR receiver
TVD_00610	COG0840	transmembrane signaling receptor activity
TVD_00615	COG2201	protein-glutamate methylesterase activity
TVD_00620	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
TVD_00630	COG0840	transmembrane signaling receptor activity
TVD_00635	COG1192	Involved in chromosome partitioning
TVD_00640	COG0835	chemotaxis
TVD_00645	COG2198	Histidine kinase
TVD_00645	COG0643	Histidine kinase
TVD_00650	COG0745	RESPONSE REGULATOR receiver
TVD_00660	COG1444	tRNA N-acetyltransferase activity
TVD_00665	COG0840	transmembrane signaling receptor activity
TVD_00685	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
TVD_00705	COG1538	Outer membrane efflux protein
TVD_00710	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
TVD_00715	COG0617	tRNA 3'-terminal CCA addition
TVD_00725	COG1012	belongs to the aldehyde dehydrogenase family
TVD_00750	COG0123	including yeast histone deacetylase and acetoin utilization protein
TVD_00760	COG1121	(ABC) transporter
TVD_00780	COG0735	belongs to the Fur family
TVD_00785	COG0189	ligase activity
TVD_00795	COG4067	protein conserved in archaea
TVD_00795	COG0189	ligase activity
TVD_00800	COG0574	Belongs to the PEP-utilizing enzyme family
TVD_00800	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
TVD_00805	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
TVD_00830	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
TVD_00840	COG1011	Hydrolase
TVD_00850	COG0494	nUDIX hydrolase
TVD_00860	COG0058	SHG alpha-glucan phosphorylase activity
TVD_00865	COG0151	Belongs to the GarS family
TVD_00870	COG0138	bifunctional purine biosynthesis protein purh
TVD_00885	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
TVD_00890	COG1410	methionine synthase
TVD_00890	COG0646	methionine synthase
TVD_00905	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
TVD_00905	COG3153	acetyltransferase
TVD_00910	COG4566	intracellular signal transduction
TVD_00965	COG0583	DNA-binding transcription factor activity
TVD_00970	COG3706	GGDEF domain
TVD_00975	COG0488	(ABC) transporter
TVD_01045	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
TVD_01060	COG4106	trans-aconitate 2-methyltransferase activity
TVD_01065	COG2207	Transcriptional regulator
TVD_01065	COG3708	Transcriptional regulator
TVD_01070	COG2918	glutathione biosynthetic process
TVD_01075	COG0435	Glutathione S-transferase
TVD_01085	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
TVD_01095	COG2814	Major facilitator Superfamily
TVD_01100	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
TVD_01105	COG2200	EAL domain
TVD_01115	COG0438	transferase activity, transferring glycosyl groups
TVD_01130	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
TVD_01140	COG0756	dUTP diphosphatase activity
TVD_01165	COG3263	regulation of cellular component size
TVD_01180	COG3023	N-Acetylmuramoyl-L-alanine amidase
TVD_01195	COG0483	inositol monophosphate 1-phosphatase activity
TVD_01205	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
TVD_01215	COG2264	protein methyltransferase activity
TVD_01220	COG0439	Biotin carboxylase
TVD_01225	COG0511	ligase activity, forming carbon-carbon bonds
TVD_01230	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
TVD_01235	COG2885	chlorophyll binding
TVD_01240	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
TVD_01250	COG0408	coproporphyrinogen oxidase activity
TVD_01255	COG0009	L-threonylcarbamoyladenylate synthase
TVD_01265	COG2922	Belongs to the Smg family
TVD_01270	COG0758	DNA mediated transformation
TVD_01280	COG0242	peptide deformylase activity
TVD_01285	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
TVD_01300	COG5000	phosphorelay sensor kinase activity
TVD_01305	COG2204	response regulator
TVD_01310	COG0569	domain protein
TVD_01315	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
TVD_01325	COG1560	Kdo2-lipid A biosynthetic process
TVD_01330	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
TVD_01335	COG2133	pyrroloquinoline quinone binding
TVD_01340	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
TVD_01345	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
TVD_01355	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
TVD_01370	COG0004	ammonium transporteR
TVD_01375	COG1116	anion transmembrane transporter activity
TVD_01380	COG0390	transport system, permease component
TVD_01385	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
TVD_01390	COG1166	arginine decarboxylase activity
TVD_01395	COG3100	YcgL domain-containing protein
TVD_01475	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
TVD_01485	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
TVD_01535	COG0446	pyridine nucleotide-disulphide oxidoreductase
TVD_01565	COG0745	RESPONSE REGULATOR receiver
TVD_01570	COG0642	Histidine kinase
TVD_01580	COG1643	Atp-dependent helicase
TVD_01590	COG0018	arginyl-trna synthetase
TVD_01595	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
TVD_01605	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
TVD_01610	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
TVD_01615	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
TVD_01625	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
TVD_01630	COG1058	Belongs to the CinA family
TVD_01630	COG1546	Belongs to the CinA family
TVD_01685	COG1459	type II secretion system
TVD_01700	COG3031	protein transport across the cell outer membrane
TVD_01745	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
TVD_01750	COG0358	DNA primase activity
TVD_01755	COG0067	glutamate synthase
TVD_01755	COG0069	glutamate synthase activity
TVD_01755	COG0070	glutamate synthase
TVD_01765	COG0232	Belongs to the dGTPase family. Type 2 subfamily
TVD_01770	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
TVD_01775	COG0828	Belongs to the bacterial ribosomal protein bS21 family
TVD_01785	COG0493	'glutamate synthase
TVD_01790	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
TVD_01830	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
TVD_01850	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
TVD_01860	COG1660	Displays ATPase and GTPase activities
TVD_01865	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
TVD_01880	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
TVD_01885	COG1137	ATPase activity
TVD_01900	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
TVD_01920	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
TVD_01930	COG1127	ABC transporter
TVD_01935	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
TVD_01940	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
TVD_01945	COG2854	intermembrane phospholipid transfer
TVD_01955	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
TVD_01960	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
TVD_01965	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
TVD_01975	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
TVD_01980	COG1201	RNA secondary structure unwinding
TVD_01995	COG0271	Belongs to the BolA IbaG family
TVD_02020	COG0189	ligase activity
TVD_02020	COG0569	domain protein
TVD_02035	COG3258	Cytochrome c
TVD_02045	COG0084	hydrolase, TatD family'
TVD_02050	COG0308	aminopeptidase N
TVD_02075	COG1276	copper resistance
TVD_02080	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
TVD_02090	COG0723	plastoquinol--plastocyanin reductase activity
TVD_02095	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
TVD_02100	COG2857	Cytochrome c1
TVD_02105	COG0625	glutathione transferase activity
TVD_02110	COG2969	positive regulation of protein catabolic process
TVD_02115	COG0277	FAD linked oxidase domain protein
TVD_02120	COG0792	nuclease activity
TVD_02135	COG2001	Belongs to the MraZ family
TVD_02140	COG0275	rRNA processing
TVD_02145	COG3116	cell division
TVD_02155	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
TVD_02160	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
TVD_02165	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
TVD_02170	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
TVD_02175	COG0772	Belongs to the SEDS family
TVD_02180	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
TVD_02185	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
TVD_02190	COG0812	UDP-N-acetylmuramate dehydrogenase activity
TVD_02195	COG1181	Belongs to the D-alanine--D-alanine ligase family
TVD_02200	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
TVD_02210	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
TVD_02215	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
TVD_02230	COG0653	protein targeting
TVD_02235	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
TVD_02240	COG0494	nUDIX hydrolase
TVD_02245	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
TVD_02250	COG0237	dephospho-CoA kinase activity
TVD_02285	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
TVD_02295	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
TVD_02305	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
TVD_02310	COG0081	regulation of translation
TVD_02315	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
TVD_02320	COG0222	ribosome binding
TVD_02325	COG0085	RNA polymerase activity
TVD_02330	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
TVD_02335	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
TVD_02340	COG0049	tRNA binding
TVD_02345	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
TVD_02350	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
TVD_02355	COG0051	transcription antitermination factor activity, RNA binding
TVD_02360	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
TVD_02365	COG0088	Forms part of the polypeptide exit tunnel
TVD_02370	COG0089	rRNA binding
TVD_02375	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
TVD_02380	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
TVD_02385	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
TVD_02390	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
TVD_02395	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
TVD_02400	COG0255	Belongs to the universal ribosomal protein uL29 family
TVD_02405	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
TVD_02410	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
TVD_02415	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
TVD_02420	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
TVD_02425	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
TVD_02430	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
TVD_02435	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
TVD_02440	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
TVD_02445	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
TVD_02450	COG1841	ribosomal large subunit assembly
TVD_02455	COG0200	Binds to the 23S rRNA
TVD_02460	COG0201	protein transport
TVD_02465	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
TVD_02470	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
TVD_02475	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
TVD_02480	COG0202	RNA polymerase activity
TVD_02485	COG0203	ribosomal protein L17
TVD_02495	COG2814	Major facilitator Superfamily
TVD_02505	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
TVD_02510	COG1702	phosphate starvation-inducible protein PhoH
TVD_02515	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
TVD_02520	COG4535	Mg2 and Co2 transporter CorC
TVD_02525	COG0815	Transfers the fatty acyl group on membrane lipoproteins
TVD_02540	COG0495	leucyl-tRNA aminoacylation
TVD_02555	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
TVD_02560	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
TVD_02570	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
TVD_02575	COG0424	maF-like protein
TVD_02585	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
TVD_02615	COG0303	'Molybdopterin
TVD_02620	COG1763	Mo-molybdopterin cofactor biosynthetic process
TVD_02625	COG0746	molybdenum cofactor guanylyltransferase activity
TVD_02640	COG4974	Belongs to the 'phage' integrase family
TVD_02655	COG3118	belongs to the thioredoxin family
TVD_02695	COG1902	pentaerythritol trinitrate reductase activity
TVD_02700	COG1929	Belongs to the glycerate kinase type-1 family
TVD_02720	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
TVD_02755	COG0676	glucose-6-phosphate 1-epimerase activity
TVD_02820	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
TVD_02840	COG4325	translation initiation factor activity
TVD_02870	COG2199	diguanylate cyclase activity
TVD_02870	COG2203	Gaf domain
TVD_02885	COG0598	Magnesium transport protein CorA
TVD_02915	COG3547	Transposase (IS116 IS110 IS902 family)
TVD_02975	COG1643	Atp-dependent helicase
TVD_03000	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
TVD_03005	COG0297	glycogen (starch) synthase activity
TVD_03010	COG0166	Belongs to the GPI family
TVD_03035	COG2067	long-chain fatty acid transport protein
TVD_03045	COG2261	transglycosylase associated protein
TVD_03050	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
TVD_03080	COG5001	Diguanylate cyclase
TVD_03080	COG5002	protein histidine kinase activity
TVD_03095	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
TVD_03130	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
TVD_03135	COG1758	RNA polymerase activity
TVD_03150	COG0142	geranyltranstransferase activity
TVD_03155	COG0261	This protein binds to 23S rRNA in the presence of protein L20
TVD_03160	COG0211	Belongs to the bacterial ribosomal protein bL27 family
TVD_03165	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
TVD_03170	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
TVD_03175	COG1570	exodeoxyribonuclease VII activity
TVD_03185	COG0516	GMP reductase activity
TVD_03185	COG0517	IMP dehydrogenase activity
TVD_03190	COG0519	Catalyzes the synthesis of GMP from XMP
TVD_03190	COG0518	GMP synthase (glutamine-hydrolyzing) activity
TVD_03220	COG0628	permease
TVD_03240	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
TVD_03270	COG3665	Urea carboxylase-associated protein
TVD_03290	COG4325	translation initiation factor activity
TVD_03330	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
TVD_03365	COG1674	ftsk spoiiie
TVD_03370	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
TVD_03375	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
TVD_03385	COG2119	membrane
TVD_03400	COG3707	response regulator
TVD_03405	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
TVD_03410	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
TVD_03415	COG1116	anion transmembrane transporter activity
TVD_03420	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
TVD_03425	COG2146	nitrite reductase [NAD(P)H] activity
TVD_03430	COG0243	molybdopterin cofactor binding
TVD_03435	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
TVD_03435	COG1648	precorrin-2 dehydrogenase activity
TVD_03455	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
TVD_03485	COG3093	addiction module antidote protein HigA
TVD_03500	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
TVD_03515	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
TVD_03525	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
TVD_03530	COG0505	Belongs to the CarA family
TVD_03540	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
TVD_03545	COG1534	Rna-binding protein
TVD_03550	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
TVD_03555	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
TVD_03560	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
TVD_03565	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
TVD_03570	COG0149	triose-phosphate isomerase activity
TVD_03585	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
TVD_03590	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
TVD_03595	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
TVD_03600	COG0649	NAD binding
TVD_03620	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
TVD_03625	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
TVD_03635	COG0713	ATP synthesis coupled electron transport
TVD_03650	COG1007	ATP synthesis coupled electron transport
TVD_03665	COG0779	Required for maturation of 30S ribosomal subunits
TVD_03670	COG2251	uridine kinase activity
TVD_03670	COG0195	Participates in both transcription termination and antitermination
TVD_03675	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
TVD_03680	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
TVD_03685	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
TVD_03690	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
TVD_03695	COG1185	polyribonucleotide nucleotidyltransferase activity
TVD_03710	COG2308	Evidence 4 Homologs of previously reported genes of
TVD_03750	COG1403	HNH endonuclease
TVD_03755	COG3706	GGDEF domain
TVD_03760	COG5001	Diguanylate cyclase
TVD_03760	COG5002	protein histidine kinase activity
TVD_03785	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
TVD_03800	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
TVD_03805	COG3706	GGDEF domain
TVD_03820	COG1309	transcriptional regulator
TVD_03835	COG3706	GGDEF domain
TVD_03865	COG2814	Major facilitator Superfamily
TVD_03885	COG2161	toxin-antitoxin pair type II binding
TVD_03915	COG0469	pyruvate kinase activity
TVD_03940	COG3273	potassium ion transport
TVD_03940	COG0471	metal ion transport
TVD_03960	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
TVD_03980	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
TVD_03995	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
TVD_04035	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
TVD_04035	COG0678	peroxiredoxin activity
TVD_04040	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
TVD_04045	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
TVD_04050	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
TVD_04055	COG0537	adenosine 5'-monophosphoramidase activity
TVD_04070	COG2154	pterin-4-alpha-carbinolamine dehydratase
TVD_04080	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
TVD_04090	COG1115	amino acid carrier protein
TVD_04100	COG0404	The glycine cleavage system catalyzes the degradation of glycine
TVD_04110	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
TVD_04115	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
TVD_04120	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
TVD_04125	COG3706	GGDEF domain
TVD_04130	COG3706	GGDEF domain
TVD_04135	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
TVD_04140	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
TVD_04150	COG1108	ABC-type Mn2 Zn2 transport systems permease components
TVD_04160	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
TVD_04165	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
TVD_04170	COG1331	Highly conserved protein containing a thioredoxin domain
TVD_04205	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
TVD_04210	COG0247	lactate metabolic process
TVD_04215	COG0277	FAD linked oxidase domain protein
TVD_04235	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
TVD_04240	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
TVD_04245	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
TVD_04245	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
TVD_04260	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
TVD_04265	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
TVD_04275	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
TVD_04280	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
TVD_04315	COG4191	Histidine kinase
TVD_04320	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
TVD_04325	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
TVD_04330	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
TVD_04335	COG2095	MarC family integral membrane protein
TVD_04350	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
TVD_04355	COG0811	peptide transport
TVD_04360	COG0848	biopolymer transport protein
TVD_04365	COG1132	(ABC) transporter
TVD_04375	COG1663	tetraacyldisaccharide 4'-kinase activity
TVD_04380	COG2835	tetraacyldisaccharide 4'-kinase activity
TVD_04385	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
TVD_04405	COG1011	Hydrolase
TVD_04435	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
TVD_04445	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
TVD_04460	COG4991	sh3 domain protein
TVD_04470	COG2111	Na H antiporter
TVD_04490	COG2212	antiporter activity
TVD_04495	COG1320	monovalent cation:proton antiporter activity
TVD_04505	COG0640	Transcriptional regulator
TVD_04525	COG1434	Gram-negative-bacterium-type cell wall biogenesis
TVD_04540	COG1295	ribonuclease BN
TVD_04570	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
TVD_04580	COG4660	Part of a membrane complex involved in electron transport
TVD_04600	COG2878	Part of a membrane complex involved in electron transport
TVD_04605	COG4657	Part of a membrane complex involved in electron transport
TVD_04615	COG0235	Class ii aldolase
TVD_04620	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
TVD_04620	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
TVD_04625	COG0489	protein tyrosine kinase activity
TVD_04630	COG0717	Belongs to the dCTP deaminase family
TVD_04635	COG0549	Belongs to the carbamate kinase family
TVD_04655	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
TVD_04660	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
TVD_04670	COG4206	TonB-dependent receptor
TVD_04675	COG2096	Adenosyltransferase
TVD_04705	COG1648	precorrin-2 dehydrogenase activity
TVD_04705	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
TVD_04710	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
TVD_04715	COG1131	(ABC) transporter
TVD_04720	COG0842	Transport permease protein
TVD_04790	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
TVD_04810	COG1672	PFAM Archaeal ATPase
TVD_04810	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
TVD_04825	COG0415	Belongs to the DNA photolyase family
TVD_04830	COG3046	protein related to deoxyribodipyrimidine photolyase
TVD_04835	COG0789	Transcriptional regulator
TVD_04840	COG1331	Highly conserved protein containing a thioredoxin domain
TVD_04865	COG1045	serine acetyltransferase
TVD_04875	COG1104	cysteine desulfurase activity
TVD_04880	COG0822	iron-sulfur transferase activity
TVD_04885	COG0316	Belongs to the HesB IscA family
TVD_04895	COG0443	Heat shock 70 kDa protein
TVD_04910	COG0105	UTP biosynthetic process
TVD_04915	COG0820	rRNA (adenine-C2-)-methyltransferase activity
TVD_04925	COG1426	Protein conserved in bacteria
TVD_04930	COG0124	histidyl-tRNA synthetase
TVD_04945	COG1160	GTP binding
TVD_04950	COG0436	Aminotransferase
TVD_04970	COG0733	neurotransmitter:sodium symporter activity
TVD_04975	COG0033	Phosphoglucomutase
TVD_04990	COG5002	protein histidine kinase activity
TVD_04995	COG0455	bacterial-type flagellum organization
TVD_05000	COG1671	Belongs to the UPF0178 family
TVD_05030	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
TVD_05040	COG1070	Carbohydrate kinase
TVD_05045	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
TVD_05050	COG1196	nuclear chromosome segregation
TVD_05060	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
TVD_05100	COG1086	Polysaccharide biosynthesis protein
TVD_05105	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
TVD_05110	COG1083	cytidylyl-transferase
TVD_05125	COG2089	acid synthase
TVD_05170	COG1215	transferase activity, transferring glycosyl groups
TVD_05175	COG3547	Transposase (IS116 IS110 IS902 family)
TVD_05185	COG3547	Transposase (IS116 IS110 IS902 family)
TVD_05220	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
TVD_05265	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
TVD_05270	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
TVD_05275	COG1074	ATP-dependent DNA helicase activity
TVD_05280	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
TVD_05295	COG5002	protein histidine kinase activity
TVD_05295	COG5001	Diguanylate cyclase
TVD_05300	COG5001	Diguanylate cyclase
TVD_05300	COG3300	MHYT domain
TVD_05305	COG0513	Belongs to the DEAD box helicase family
TVD_05330	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
TVD_05335	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
TVD_05355	COG3852	Histidine kinase
TVD_05365	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
TVD_05370	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
TVD_05400	COG2738	Putative neutral zinc metallopeptidase
TVD_05405	COG0668	transmembrane transport
TVD_05450	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
TVD_05460	COG3609	addiction module antidote protein, CC2985 family
TVD_05475	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
TVD_05485	COG0473	3-isopropylmalate dehydrogenase activity
TVD_05490	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
TVD_05505	COG0101	tRNA pseudouridine synthase activity
TVD_05510	COG0135	phosphoribosylanthranilate isomerase activity
TVD_05515	COG0133	tryptophan synthase activity
TVD_05520	COG0159	tryptophan synthase activity
TVD_05525	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
TVD_05530	COG0285	dihydrofolate synthase activity
TVD_05540	COG1286	toxin biosynthetic process
TVD_05555	COG1959	2 iron, 2 sulfur cluster binding
TVD_05570	COG0714	Associated with various cellular activities
TVD_05575	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
TVD_05580	COG1127	ABC transporter
TVD_05595	COG0386	Belongs to the glutathione peroxidase family
TVD_05600	COG0590	tRNA wobble adenosine to inosine editing
TVD_05605	COG1714	RDD family
TVD_05620	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
TVD_05625	COG0343	queuine tRNA-ribosyltransferase activity
TVD_05630	COG1862	Preprotein translocase
TVD_05635	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
TVD_05640	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
TVD_05650	COG0791	NLP P60 protein
TVD_05665	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
TVD_05675	COG1199	ATP-dependent helicase activity
TVD_05685	COG0585	pseudouridine synthase activity
TVD_05690	COG1366	Belongs to the anti-sigma-factor antagonist family
TVD_05705	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
TVD_05710	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
TVD_05715	COG1238	metal cluster binding
TVD_05720	COG4942	peptidase
TVD_05735	COG0436	Aminotransferase
TVD_05745	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
TVD_05750	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
TVD_05750	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
TVD_05755	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
TVD_05785	COG3047	cAMP biosynthetic process
TVD_05810	COG3706	GGDEF domain
TVD_05820	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
TVD_05825	COG0662	Cupin 2, conserved barrel domain protein
TVD_05825	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
TVD_05835	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
TVD_05845	COG0587	DNA-directed DNA polymerase activity
TVD_05850	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
TVD_05865	COG2226	methyltransferase
TVD_05875	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
TVD_05905	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
TVD_05910	COG2135	peptidase activity
TVD_05925	COG2801	Transposase and inactivated derivatives
TVD_06010	COG1714	RDD family
TVD_06020	COG3706	GGDEF domain
TVD_06020	COG0745	RESPONSE REGULATOR receiver
TVD_06025	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
TVD_06085	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
TVD_06110	COG1196	nuclear chromosome segregation
TVD_06155	COG0210	DNA helicase
TVD_06170	COG0582	viral genome integration into host DNA
TVD_06190	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
TVD_06195	COG1714	RDD family
TVD_06200	COG2081	HI0933 family
TVD_06205	COG3588	fructose-bisphosphate aldolase
TVD_06210	COG0737	Belongs to the 5'-nucleotidase family
TVD_06215	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
TVD_06220	COG0432	Pfam Uncharacterised protein family UPF0047
TVD_06235	COG3604	Transcriptional regulator
TVD_06240	COG2204	response regulator
TVD_06245	COG1677	Flagellar hook-basal body complex protein FliE
TVD_06255	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
TVD_06275	COG3144	bacterial-type flagellum assembly
TVD_06305	COG1987	bacterial-type flagellum assembly
TVD_06310	COG1684	flagellar biosynthetic protein fliR
TVD_06330	COG0455	bacterial-type flagellum organization
TVD_06345	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
TVD_06350	COG2198	Histidine kinase
TVD_06350	COG0643	Histidine kinase
TVD_06355	COG2201	protein-glutamate methylesterase activity
TVD_06360	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
TVD_06365	COG1360	Flagellar Motor Protein
TVD_06370	COG1192	Involved in chromosome partitioning
TVD_06405	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
TVD_06410	COG1530	ribonuclease E activity
TVD_06420	COG0546	phosphoglycolate phosphatase activity
TVD_06425	COG0616	signal peptide processing
TVD_06435	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
TVD_06445	COG2957	Belongs to the agmatine deiminase family
TVD_06455	COG4591	ABC-type transport system involved in lipoprotein release permease component
TVD_06460	COG1136	(ABC) transporter
TVD_06475	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
TVD_06485	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
TVD_06490	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
TVD_06505	COG0287	Prephenate dehydrogenase
TVD_06510	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
TVD_06525	COG0776	regulation of translation
TVD_06535	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
TVD_06540	COG0284	orotidine-5'-phosphate decarboxylase activity
TVD_06545	COG1596	polysaccharide export
TVD_06545	COG1555	photosystem II stabilization
TVD_06550	COG1210	Utp--glucose-1-phosphate uridylyltransferase
TVD_06560	COG0129	dihydroxy-acid dehydratase activity
TVD_06575	COG0235	Class ii aldolase
TVD_06580	COG3909	cytochrome
TVD_06585	COG2010	Cytochrome c
TVD_06655	COG1472	Belongs to the glycosyl hydrolase 3 family
TVD_06685	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
TVD_06700	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
TVD_06705	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
TVD_06715	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
TVD_06720	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
TVD_06725	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
TVD_06740	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
TVD_06745	COG0542	response to heat
TVD_06750	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
TVD_06765	COG0482	sulfurtransferase activity
TVD_06770	COG2915	High frequency lysogenization protein hflD homolog
TVD_06805	COG2850	peptidyl-arginine hydroxylation
TVD_06810	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
TVD_06815	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
TVD_06820	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
TVD_06825	COG1131	(ABC) transporter
TVD_06830	COG0842	Transport permease protein
TVD_06835	COG0739	heme binding
TVD_06840	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
TVD_06840	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
TVD_06845	COG5001	Diguanylate cyclase
TVD_06860	COG0501	Belongs to the peptidase M48B family
TVD_06865	COG1704	LemA family
TVD_06875	COG1360	Flagellar Motor Protein
TVD_06910	COG4181	ATPase activity
TVD_06915	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
TVD_06920	COG1968	undecaprenyl-diphosphatase activity
TVD_06930	COG1959	2 iron, 2 sulfur cluster binding
TVD_06970	COG0418	dihydroorotase activity
TVD_06975	COG1872	DUF167
TVD_06980	COG2226	methyltransferase
TVD_06985	COG0251	oxidation-reduction process
TVD_06990	COG1073	alpha beta
TVD_06995	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
TVD_07005	COG2827	Endonuclease containing a URI domain
TVD_07065	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
TVD_07075	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
TVD_07085	COG1492	cobalamin metabolic process
TVD_07095	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
TVD_07100	COG0778	Nitroreductase
TVD_07105	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
TVD_07110	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
TVD_07115	COG1120	ATPase activity
TVD_07125	COG1741	Belongs to the pirin family
TVD_07135	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
TVD_07140	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
TVD_07145	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
TVD_07150	COG0148	phosphopyruvate hydratase activity
TVD_07155	COG2877	3-deoxy-8-phosphooctulonate synthase activity
TVD_07160	COG0504	CTP synthase activity
TVD_07170	COG3447	MASE1 domain protein
TVD_07170	COG5001	Diguanylate cyclase
TVD_07170	COG5002	protein histidine kinase activity
TVD_07190	COG0037	tRNA processing
TVD_07195	COG0825	malonyl-CoA metabolic process
TVD_07205	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
TVD_07210	COG0673	inositol 2-dehydrogenase activity
TVD_07220	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
TVD_07225	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
TVD_07230	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
TVD_07235	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
TVD_07245	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
TVD_07255	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
TVD_07260	COG0575	Belongs to the CDS family
TVD_07265	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
TVD_07270	COG0233	cytoplasmic translational termination
TVD_07275	COG0528	UMP kinase activity
TVD_07280	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
TVD_07285	COG0052	Belongs to the universal ribosomal protein uS2 family
TVD_07290	COG0024	Methionine aminopeptidase
TVD_07295	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
TVD_07320	COG0655	NAD(P)H dehydrogenase (quinone) activity
TVD_07330	COG0402	S-adenosylhomocysteine deaminase activity
TVD_07335	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
TVD_07355	COG0635	Involved in the biosynthesis of porphyrin-containing compound
TVD_07360	COG1562	ergosterol biosynthetic process
TVD_07365	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
TVD_07370	COG1028	Short-chain dehydrogenase reductase Sdr
TVD_07390	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
TVD_07390	COG0069	glutamate synthase activity
TVD_07395	COG0259	pyridoxamine-phosphate oxidase activity
TVD_07425	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
TVD_07430	COG2900	Belongs to the SlyX family
TVD_07435	COG0742	ribosomal rna small subunit methyltransferase
TVD_07450	COG2363	Small membrane protein
TVD_07455	COG1965	Belongs to the frataxin family
TVD_07470	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
TVD_07475	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
TVD_07480	COG0277	FAD linked oxidase domain protein
TVD_07490	COG3447	MASE1 domain protein
TVD_07490	COG5001	Diguanylate cyclase
TVD_07490	COG5002	protein histidine kinase activity
TVD_07520	COG1063	alcohol dehydrogenase
TVD_07535	COG2095	MarC family integral membrane protein
TVD_07550	COG0640	Transcriptional regulator
TVD_07570	COG0513	Belongs to the DEAD box helicase family
TVD_07595	COG3237	CsbD-like
TVD_07630	COG0815	Transfers the fatty acyl group on membrane lipoproteins
TVD_07635	COG0577	efflux transmembrane transporter activity
TVD_07635	COG1136	(ABC) transporter
TVD_07640	COG0577	efflux transmembrane transporter activity
TVD_07640	COG1136	(ABC) transporter
TVD_07645	COG1566	PFAM secretion protein HlyD family protein
TVD_07665	COG1366	Belongs to the anti-sigma-factor antagonist family
TVD_07670	COG2208	phosphoserine phosphatase activity
TVD_07670	COG2770	Histidine kinase
TVD_07675	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
TVD_07685	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
TVD_07690	COG3459	Glycosyltransferase 36 associated
TVD_07705	COG2823	Periplasmic or secreted lipoprotein
TVD_07725	COG3239	Fatty acid desaturase
TVD_07735	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
TVD_07740	COG1216	Glycosyl transferase, family 2
TVD_07750	COG0798	PFAM Bile acid sodium symporter
TVD_07760	COG0640	Transcriptional regulator
TVD_07765	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
TVD_07770	COG2171	N-acyltransferase activity
TVD_07775	COG1393	Belongs to the ArsC family
TVD_07790	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
TVD_07795	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
TVD_07795	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
TVD_07800	COG0741	lytic transglycosylase activity
TVD_07815	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
TVD_07835	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
TVD_07860	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
TVD_07865	COG1256	bacterial-type flagellum assembly
TVD_07870	COG1705	Flagellar rod assembly protein muramidase FlgJ
TVD_07870	COG3951	Flagellar rod assembly protein muramidase FlgJ
TVD_07875	COG1706	bacterial-type flagellum-dependent cell motility
TVD_07880	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
TVD_07885	COG4786	Flagellar basal body rod
TVD_07890	COG4787	bacterial-type flagellum-dependent cell motility
TVD_07895	COG1749	Flagellar hook protein flgE
TVD_07900	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
TVD_07905	COG1558	bacterial-type flagellum-dependent cell motility
TVD_07915	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
TVD_07920	COG0784	Response regulator, receiver
TVD_07920	COG0835	chemotaxis
TVD_07955	COG0776	regulation of translation
TVD_07960	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
TVD_07960	COG0072	phenylalanine-tRNA ligase activity
TVD_07965	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
TVD_07970	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
TVD_07975	COG0291	Belongs to the bacterial ribosomal protein bL35 family
TVD_07980	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
TVD_07985	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
TVD_08000	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
TVD_08035	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
TVD_08040	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
TVD_08050	COG1053	succinate dehydrogenase
TVD_08055	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
TVD_08070	COG0446	pyridine nucleotide-disulphide oxidoreductase
TVD_08090	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
TVD_08090	COG1116	anion transmembrane transporter activity
TVD_08095	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
TVD_08100	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
TVD_08110	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
TVD_08115	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
TVD_08120	COG1116	anion transmembrane transporter activity
TVD_08125	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
TVD_08135	COG0582	viral genome integration into host DNA
TVD_08155	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
TVD_08195	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
TVD_08225	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
TVD_08230	COG3706	GGDEF domain
TVD_08230	COG0745	RESPONSE REGULATOR receiver
TVD_08285	COG2135	peptidase activity
TVD_08290	COG3359	exonuclease
TVD_08295	COG1205	dead DEAH box helicase
TVD_08295	COG1111	helicase
TVD_08300	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
TVD_08310	COG2801	Transposase and inactivated derivatives
TVD_08355	COG0573	inorganic phosphate transmembrane transporter activity
TVD_08360	COG0573	inorganic phosphate transmembrane transporter activity
TVD_08365	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
TVD_08370	COG0704	Plays a role in the regulation of phosphate uptake
TVD_08395	COG0471	metal ion transport
TVD_08405	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
TVD_08410	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
TVD_08415	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
TVD_08420	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
TVD_08445	COG1136	(ABC) transporter
TVD_08450	COG2239	Acts as a magnesium transporter
TVD_08455	COG2239	Acts as a magnesium transporter
TVD_08485	COG3706	GGDEF domain
TVD_08505	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
TVD_08510	COG0322	excinuclease ABC activity
TVD_08525	COG1573	uracil-dna glycosylase
TVD_08535	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
TVD_08540	COG0416	fatty acid biosynthetic process
TVD_08545	COG0333	Belongs to the bacterial ribosomal protein bL32 family
TVD_08555	COG0439	Biotin carboxylase
TVD_08560	COG0511	ligase activity, forming carbon-carbon bonds
TVD_08560	COG5016	pyruvate
TVD_08565	COG0424	maF-like protein
TVD_08585	COG1848	Toxic component of a toxin-antitoxin (TA) module. An RNase
TVD_08590	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
TVD_08595	COG1522	sequence-specific DNA binding
TVD_08600	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
TVD_08605	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
TVD_08615	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
TVD_08630	COG0509	glycine decarboxylation via glycine cleavage system
TVD_08640	COG3945	hemerythrin HHE cation binding domain
TVD_08670	COG0521	Mo-molybdopterin cofactor biosynthetic process
TVD_08680	COG0367	asparagine synthase
TVD_08685	COG0583	DNA-binding transcription factor activity
TVD_08695	COG0616	signal peptide processing
TVD_08710	COG4067	protein conserved in archaea
TVD_08710	COG0189	ligase activity
TVD_08715	COG0189	ligase activity
TVD_08735	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
TVD_08750	COG0133	tryptophan synthase activity
TVD_08755	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
TVD_08765	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
TVD_08790	COG2815	serine threonine protein kinase
TVD_08790	COG0515	serine threonine protein kinase
TVD_08835	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
TVD_08845	COG3706	GGDEF domain
TVD_08845	COG0745	RESPONSE REGULATOR receiver
TVD_08855	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
TVD_08865	COG2226	methyltransferase
TVD_08875	COG2203	Gaf domain
TVD_08875	COG3706	GGDEF domain
TVD_08875	COG4251	negative regulation of phosphorylation
TVD_08875	COG5001	Diguanylate cyclase
TVD_08880	COG0604	alcohol dehydrogenase
TVD_08905	COG1752	Esterase of the alpha-beta hydrolase superfamily
TVD_08915	COG4943	cyclic-guanylate-specific phosphodiesterase activity
TVD_08965	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
TVD_09000	COG2258	MOSC domain
TVD_09005	COG2249	NAD(P)H dehydrogenase (quinone) activity
TVD_09020	COG1620	l-lactate permease
TVD_09025	COG3384	dioxygenase
TVD_09095	COG0463	Glycosyl transferase, family 2
TVD_09100	COG3706	GGDEF domain
TVD_09115	COG4946	Tricorn protease homolog
TVD_09115	COG0823	Involved in the tonB-independent uptake of proteins
TVD_09115	COG1506	peptidase
TVD_09135	COG2357	RelA SpoT domain protein
TVD_09140	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
TVD_09145	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
TVD_09145	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
TVD_09150	COG0492	ferredoxin-NADP+ reductase activity
TVD_09160	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
TVD_09180	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
TVD_09185	COG0527	aspartate kinase activity
TVD_09190	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
TVD_09205	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
TVD_09210	COG3264	Mechanosensitive ion channel
TVD_09210	COG1196	nuclear chromosome segregation
TVD_09215	COG1546	Belongs to the CinA family
TVD_09225	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
TVD_09230	COG1538	Outer membrane efflux protein
TVD_09240	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
TVD_09270	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
TVD_09275	COG0392	lysyltransferase activity
TVD_09275	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
TVD_09280	COG0277	FAD linked oxidase domain protein
TVD_09290	COG0560	Phosphoserine phosphatase
TVD_09315	COG1320	monovalent cation:proton antiporter activity
TVD_09330	COG0651	ATP synthesis coupled electron transport
TVD_09335	COG0651	ATP synthesis coupled electron transport
TVD_09360	COG4251	negative regulation of phosphorylation
TVD_09370	COG0488	(ABC) transporter
TVD_09395	COG1215	transferase activity, transferring glycosyl groups
TVD_09410	COG0583	DNA-binding transcription factor activity
TVD_09430	COG1192	Involved in chromosome partitioning
TVD_09440	COG2193	ferroxidase activity
TVD_09485	COG1850	ribulose-bisphosphate carboxylase activity
TVD_09490	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
TVD_09495	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
TVD_09515	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
TVD_09520	COG2894	cell division
TVD_09525	COG0850	regulation of cytokinetic process
TVD_09580	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
TVD_09590	COG2084	Dehydrogenase
TVD_09620	COG0116	Belongs to the methyltransferase superfamily
TVD_09620	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
TVD_09640	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
TVD_09645	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
TVD_09650	COG0180	Tryptophanyl-tRNA synthetase
TVD_09660	COG0009	L-threonylcarbamoyladenylate synthase
TVD_09665	COG2350	Protein conserved in bacteria
TVD_09670	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
TVD_09720	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
TVD_09745	COG0523	cobalamin synthesis protein
TVD_09750	COG0730	response to heat
TVD_09760	COG5001	Diguanylate cyclase
TVD_09760	COG3300	MHYT domain
TVD_09770	COG4251	negative regulation of phosphorylation
TVD_09775	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
TVD_09780	COG0215	cysteine-tRNA ligase activity
TVD_09785	COG3683	transport system, periplasmic component
TVD_09795	COG1022	Amp-dependent synthetase and ligase
TVD_09800	COG2210	Belongs to the sulfur carrier protein TusA family
TVD_09885	COG2353	YceI-like domain
TVD_09900	COG2233	PERMEase
TVD_09925	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
TVD_09940	COG2153	protein acetylation
TVD_09965	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
TVD_09970	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
TVD_09975	COG0006	proline dipeptidase activity
TVD_09980	COG3079	Belongs to the UPF0149 family
TVD_10000	COG0632	four-way junction helicase activity
TVD_10005	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
TVD_10010	COG0217	transcriptional regulatory protein
TVD_10020	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
TVD_10040	COG0300	oxidoreductase activity
TVD_10045	COG0700	Nucleoside recognition
TVD_10050	COG2202	Pas domain
TVD_10050	COG2205	protein histidine kinase activity
TVD_10065	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
TVD_10080	COG0442	prolyl-tRNA aminoacylation
TVD_10095	COG3273	potassium ion transport
TVD_10095	COG0471	metal ion transport
TVD_10105	COG1254	Belongs to the acylphosphatase family
TVD_10110	COG1393	Belongs to the ArsC family
TVD_10125	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
TVD_10130	COG0628	permease
TVD_10135	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
TVD_10145	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
TVD_10150	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
TVD_10160	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
TVD_10190	COG1278	Cold shock
TVD_10195	COG0501	Belongs to the peptidase M48B family
TVD_10205	COG0312	modulator of DNA gyrase
TVD_10215	COG0312	modulator of DNA gyrase
TVD_10220	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
TVD_10230	COG1530	ribonuclease E activity
TVD_10255	COG5001	Diguanylate cyclase
TVD_10255	COG2203	Gaf domain
TVD_10255	COG4251	negative regulation of phosphorylation
TVD_10255	COG3706	GGDEF domain
TVD_10260	COG0227	Belongs to the bacterial ribosomal protein bL28 family
TVD_10265	COG0267	Belongs to the bacterial ribosomal protein bL33 family
TVD_10285	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
TVD_10295	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
TVD_10300	COG0601	transmembrane transport
TVD_10315	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
TVD_10335	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
TVD_10340	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
TVD_10345	COG0740	serine-type endopeptidase activity
TVD_10350	COG0544	peptidyl-prolyl cis-trans isomerase activity
TVD_10365	COG2391	methyltransferase activity
TVD_10370	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
TVD_10375	COG0602	queuosine metabolic process
TVD_10390	COG0823	Involved in the tonB-independent uptake of proteins
TVD_10410	COG0824	Thioesterase
TVD_10415	COG2255	four-way junction helicase activity
TVD_10425	COG0688	phosphatidylethanolamine metabolic process
TVD_10435	COG0514	ATP-dependent DNA helicase (RecQ)
TVD_10445	COG3706	GGDEF domain
TVD_10455	COG5265	(ABC) transporter
TVD_10470	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
TVD_10485	COG1573	uracil-dna glycosylase
TVD_10490	COG1183	phosphatidylcholine synthase activity
TVD_10495	COG0688	phosphatidylethanolamine metabolic process
TVD_10500	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
TVD_10505	COG0440	acetolactate synthase activity
TVD_10510	COG0028	Belongs to the TPP enzyme family
TVD_10515	COG1193	negative regulation of DNA recombination
TVD_10530	COG0123	including yeast histone deacetylase and acetoin utilization protein
TVD_10555	COG4176	ABC-type proline glycine betaine transport system permease component
TVD_10590	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
TVD_10600	COG0095	Lipoate-protein ligase
TVD_10610	COG0509	glycine decarboxylation via glycine cleavage system
TVD_10620	COG0509	glycine decarboxylation via glycine cleavage system
TVD_10625	COG2048	Heterodisulfide reductase, subunit B
TVD_10655	COG0425	Belongs to the sulfur carrier protein TusA family
TVD_10660	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
TVD_10670	COG4783	chaperone-mediated protein folding
TVD_10675	COG0737	Belongs to the 5'-nucleotidase family
TVD_10740	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
TVD_10790	COG2199	diguanylate cyclase activity
TVD_10790	COG2203	Gaf domain
TVD_10795	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
TVD_10800	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
TVD_10805	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
TVD_10810	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
TVD_10815	COG2833	Protein of unknown function (DUF455)
TVD_10820	COG2132	Multicopper oxidase
TVD_10825	COG2217	Heavy metal translocating P-type atpase
TVD_10830	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
TVD_10840	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
TVD_10845	COG0305	Participates in initiation and elongation during chromosome replication
TVD_10850	COG0359	binds to the 23S rRNA
TVD_10860	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
TVD_10865	COG0360	Binds together with S18 to 16S ribosomal RNA
TVD_10870	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
TVD_10875	COG0557	exoribonuclease II activity
TVD_10885	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
TVD_10890	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
TVD_10895	COG0330	HflC and HflK could
TVD_10900	COG0330	HflC and HflK could
TVD_10905	COG0736	holo-[acyl-carrier-protein] synthase activity
TVD_10910	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
TVD_10915	COG1381	Involved in DNA repair and RecF pathway recombination
TVD_10920	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
TVD_10925	COG0571	ribonuclease III activity
TVD_10935	COG0681	Belongs to the peptidase S26 family
TVD_10940	COG0481	GTPase activity
TVD_10950	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
TVD_10980	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
TVD_10980	COG1017	nitric oxide dioxygenase activity
TVD_10985	COG3956	TIGRFAM MazG family protein
TVD_10990	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
TVD_10990	COG3453	Protein conserved in bacteria
TVD_11020	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
TVD_11025	COG0321	lipoyl(octanoyl) transferase activity
TVD_11030	COG2921	Belongs to the UPF0250 family
TVD_11035	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
TVD_11040	COG1686	Belongs to the peptidase S11 family
TVD_11050	COG2951	lytic endotransglycosylase activity
TVD_11055	COG0772	Belongs to the SEDS family
TVD_11060	COG0768	penicillin binding
TVD_11065	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
TVD_11070	COG0563	adenylate kinase activity
TVD_11075	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
TVD_11080	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
TVD_11085	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
TVD_11090	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
TVD_11100	COG2967	ApaG domain
TVD_11105	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
TVD_11110	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
TVD_11115	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
TVD_11130	COG0247	lactate metabolic process
TVD_11135	COG2801	Transposase and inactivated derivatives
TVD_11155	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
TVD_11160	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
TVD_11170	COG2204	response regulator
TVD_11175	COG4191	Histidine kinase
TVD_11180	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
TVD_11185	COG0501	Belongs to the peptidase M48B family
TVD_11195	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
TVD_11225	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
TVD_11230	COG0693	protein deglycase activity
TVD_11235	COG0793	Belongs to the peptidase S41A family
TVD_11240	COG4942	peptidase
TVD_11245	COG0640	Transcriptional regulator
TVD_11250	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
TVD_11255	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
TVD_11260	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
TVD_11265	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
TVD_11280	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
TVD_11300	COG0542	response to heat
TVD_11310	COG0564	pseudouridine synthase activity
TVD_11320	COG0347	Belongs to the P(II) protein family
TVD_11325	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
TVD_11325	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
TVD_11330	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
TVD_11335	COG0045	succinate-CoA ligase (ADP-forming) activity
TVD_11340	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
TVD_11345	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
TVD_11350	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
TVD_11355	COG1428	Deoxynucleoside kinase
TVD_11365	COG0617	tRNA 3'-terminal CCA addition
TVD_11385	COG0735	belongs to the Fur family
TVD_11395	COG2914	Belongs to the UPF0125 (RnfH) family
TVD_11400	COG2867	negative regulation of translational initiation
TVD_11405	COG0733	neurotransmitter:sodium symporter activity
TVD_11410	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
TVD_11415	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
TVD_11420	COG0328	RNA-DNA hybrid ribonuclease activity
TVD_11430	COG1388	LysM domain
TVD_11430	COG0741	lytic transglycosylase activity
TVD_11435	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
TVD_11440	COG1923	regulation of RNA biosynthetic process
TVD_11445	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
TVD_11455	COG0860	N-Acetylmuramoyl-L-alanine amidase
TVD_11460	COG0802	atpase or kinase
TVD_11465	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
TVD_11465	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
TVD_11475	COG5001	Diguanylate cyclase
TVD_11475	COG5002	protein histidine kinase activity
TVD_11485	COG0484	heat shock protein binding
TVD_11490	COG3012	SEC-C Motif Domain Protein
TVD_11495	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
TVD_11500	COG0525	valine-tRNA ligase activity
TVD_11520	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
TVD_11535	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
TVD_11570	COG1028	Short-chain dehydrogenase reductase Sdr
TVD_11575	COG0463	Glycosyl transferase, family 2
TVD_11605	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
TVD_11610	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
TVD_11615	COG1509	lysine 2,3-aminomutase activity
TVD_11625	COG2200	EAL domain
TVD_11630	COG0484	heat shock protein binding
TVD_11635	COG0443	Heat shock 70 kDa protein
TVD_11640	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
TVD_11645	COG1420	regulation of RNA biosynthetic process
TVD_11650	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
TVD_11655	COG0497	DNA recombination
TVD_11665	COG2983	Belongs to the UPF0260 family
TVD_11735	COG0326	Molecular chaperone. Has ATPase activity
TVD_11740	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
TVD_11745	COG2010	Cytochrome c
TVD_11750	COG2010	Cytochrome c
TVD_11755	COG3258	Cytochrome c
TVD_11765	COG0335	large ribosomal subunit rRNA binding
TVD_11770	COG0336	Belongs to the RNA methyltransferase TrmD family
TVD_11775	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
TVD_11780	COG0228	four-way junction DNA binding
TVD_11785	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
TVD_11790	COG4137	Cytochrome C assembly protein
TVD_11795	COG4536	flavin adenine dinucleotide binding
TVD_11825	COG1592	Rubrerythrin
TVD_11830	COG1722	exodeoxyribonuclease VII activity
TVD_11835	COG0142	geranyltranstransferase activity
TVD_11840	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
TVD_11850	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
TVD_11855	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
TVD_11860	COG2716	regulation of RNA biosynthetic process
TVD_11865	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
TVD_11870	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
TVD_11875	COG1234	tRNA 3'-trailer cleavage
TVD_11910	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
TVD_11920	COG0316	Belongs to the HesB IscA family
TVD_11935	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
TVD_11955	COG0494	nUDIX hydrolase
TVD_11970	COG0351	phosphomethylpyrimidine kinase
TVD_11975	COG0352	thiamine-phosphate diphosphorylase activity
TVD_11980	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
TVD_11985	COG0730	response to heat
TVD_11995	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
TVD_12005	COG0163	prenyltransferase activity
TVD_12010	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
TVD_12020	COG2853	Lipoprotein
TVD_12025	COG3706	GGDEF domain
TVD_12030	COG0137	argininosuccinate synthase activity
TVD_12040	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
TVD_12045	COG0508	dehydrogenase complex catalyzes the overall conversion of
TVD_12060	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
TVD_12065	COG0012	GTP binding
TVD_12070	COG0193	aminoacyl-tRNA hydrolase activity
TVD_12075	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
TVD_12080	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
TVD_12090	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
TVD_12095	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
TVD_12105	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
TVD_12110	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
TVD_12135	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
TVD_12140	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
TVD_12145	COG0154	amidase activity
TVD_12150	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
TVD_12155	COG1077	Cell shape determining protein MreB Mrl
TVD_12160	COG1792	Involved in formation and maintenance of cell shape
TVD_12175	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
TVD_12185	COG1519	Transferase
TVD_12190	COG1560	Kdo2-lipid A biosynthetic process
TVD_12200	COG3660	Nucleoside-diphosphate-sugar epimerase
TVD_12245	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
TVD_12250	COG1840	ABC-type Fe3 transport system, periplasmic component
TVD_12255	COG1178	ABC-type Fe3 transport system permease component
TVD_12260	COG3842	ATPase activity
TVD_12265	COG0729	surface antigen
TVD_12280	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
TVD_12280	COG2885	chlorophyll binding
TVD_12285	COG0459	protein refolding
TVD_12290	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
TVD_12315	COG1324	tolerance protein
TVD_12320	COG4232	protein-disulfide reductase activity
TVD_12325	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
TVD_12330	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
TVD_12345	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
TVD_12355	COG0156	8-amino-7-oxononanoate synthase activity
TVD_12360	COG2003	Belongs to the UPF0758 family
TVD_12365	COG0129	dihydroxy-acid dehydratase activity
TVD_12380	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
TVD_12380	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
TVD_12385	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
TVD_12390	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
TVD_12395	COG3178	'Phosphotransferase
TVD_12400	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
TVD_12440	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
TVD_12465	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
TVD_12470	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
TVD_12475	COG1765	OsmC-like protein
TVD_12485	COG0134	indole-3-glycerol-phosphate synthase activity
TVD_12490	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
TVD_12495	COG2814	Major facilitator Superfamily
TVD_12515	COG0546	phosphoglycolate phosphatase activity
TVD_12535	COG2813	Specifically methylates the guanine in position
TVD_12540	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
TVD_12545	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
TVD_12550	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
TVD_12565	COG0191	fructose-bisphosphate aldolase activity
TVD_12570	COG0469	pyruvate kinase activity
TVD_12575	COG0126	phosphoglycerate kinase activity
TVD_12580	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
TVD_12585	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
TVD_12590	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
TVD_12595	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
TVD_12600	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
TVD_12605	COG1385	rRNA (uridine-N3-)-methyltransferase activity
TVD_12615	COG0643	Histidine kinase
TVD_12615	COG2198	Histidine kinase
TVD_12620	COG0840	transmembrane signaling receptor activity
TVD_12625	COG0835	chemotaxis
TVD_12640	COG0189	ligase activity
TVD_12665	COG1678	Uncharacterized ACR, COG1678
TVD_12670	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
TVD_12680	COG0540	Belongs to the ATCase OTCase family
TVD_12730	COG0741	lytic transglycosylase activity
TVD_12750	COG0039	L-malate dehydrogenase activity
TVD_12755	COG0281	malic enzyme
TVD_12760	COG4783	chaperone-mediated protein folding
TVD_12770	COG0254	rRNA binding
TVD_12785	COG0742	ribosomal rna small subunit methyltransferase
TVD_12800	COG0552	protein localization to endoplasmic reticulum
TVD_12805	COG2884	Cell division ATP-binding protein ftsE
TVD_12810	COG2177	Part of the ABC transporter FtsEX involved in
TVD_12835	COG0348	domain, Protein
TVD_12840	COG2010	Cytochrome c
TVD_12855	COG3278	Belongs to the heme-copper respiratory oxidase family
TVD_12870	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
TVD_12875	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
TVD_12915	COG3302	dmso reductase anchor subunit
TVD_12920	COG0437	4 iron, 4 sulfur cluster binding
TVD_12925	COG0243	molybdopterin cofactor binding
TVD_12930	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
TVD_12940	COG0659	secondary active sulfate transmembrane transporter activity
TVD_12950	COG4772	TonB-dependent receptor
TVD_12975	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
TVD_12980	COG0167	dihydroorotate dehydrogenase activity
TVD_12990	COG3852	Histidine kinase
TVD_13045	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
TVD_13065	COG3706	GGDEF domain
TVD_13070	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
TVD_13070	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
TVD_13115	COG2226	methyltransferase
TVD_13125	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
TVD_13130	COG3706	GGDEF domain
TVD_13130	COG0745	RESPONSE REGULATOR receiver
TVD_13140	COG0508	dehydrogenase complex catalyzes the overall conversion of
TVD_13145	COG0567	Dehydrogenase, E1 component
TVD_13150	COG0210	DNA helicase
TVD_13160	COG0268	Binds directly to 16S ribosomal RNA
TVD_13170	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
TVD_13210	COG0205	6-phosphofructokinase activity
TVD_13215	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
TVD_13235	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
TVD_13255	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
TVD_13290	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
TVD_13310	COG0375	protein maturation
TVD_13315	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
TVD_13345	COG0745	RESPONSE REGULATOR receiver
TVD_13345	COG3706	GGDEF domain
TVD_13395	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
TVD_13400	COG1392	Phosphate transport regulator
TVD_13405	COG0306	phosphate transporter
TVD_13410	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
TVD_13420	COG0165	Argininosuccinate lyase
TVD_13425	COG3275	phosphorelay sensor kinase activity
TVD_13430	COG3279	Response regulator of the LytR AlgR family
TVD_13435	COG0181	hydroxymethylbilane synthase activity
TVD_13440	COG1587	Uroporphyrinogen-III synthase
TVD_13445	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
TVD_13445	COG0543	2 iron, 2 sulfur cluster binding
TVD_13460	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
TVD_13465	COG0708	Exodeoxyribonuclease III
TVD_13470	COG0339	signal peptide processing
TVD_13480	COG0187	DNA topoisomerase II activity
TVD_13495	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
TVD_13500	COG0230	Belongs to the bacterial ribosomal protein bL34 family
TVD_13505	COG0594	ribonuclease P activity
TVD_13510	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
TVD_13515	COG0706	membrane insertase activity
TVD_13520	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
TVD_13530	COG0445	tRNA wobble uridine modification
TVD_13535	COG0357	Ribosomal RNA small subunit methyltransferase G
TVD_13540	COG1192	Involved in chromosome partitioning
TVD_13545	COG1475	DNA binding
TVD_13555	COG0356	it plays a direct role in the translocation of protons across the membrane
TVD_13565	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
TVD_13570	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
TVD_13575	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
TVD_13580	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
TVD_13585	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
TVD_13590	COG0355	proton-transporting ATP synthase activity, rotational mechanism
TVD_13595	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
TVD_13610	COG1490	D-aminoacyl-tRNA deacylase activity
TVD_13625	COG0037	tRNA processing
TVD_13635	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
TVD_13640	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
TVD_13645	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
TVD_13655	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
TVD_13660	COG4106	trans-aconitate 2-methyltransferase activity
TVD_13685	COG0131	Imidazoleglycerol-phosphate dehydratase
TVD_13690	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
TVD_13695	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
TVD_13700	COG0107	imidazoleglycerol-phosphate synthase activity
TVD_13705	COG0140	phosphoribosyl-ATP diphosphatase activity
TVD_13715	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
TVD_13720	COG0805	protein transport
TVD_13725	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
TVD_13735	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
TVD_13755	COG1846	Transcriptional regulator
TVD_13770	COG1335	isochorismatase
TVD_13775	COG4145	pantothenate transmembrane transporter activity
TVD_13780	COG0540	Belongs to the ATCase OTCase family
TVD_13785	COG0367	asparagine synthase
TVD_13790	COG0174	glutamine synthetase
TVD_13795	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
TVD_13800	COG0752	glycyl-tRNA synthetase alpha subunit