locus-tag	class	description
Tbd_0001	ENOG4105CI4	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity)
Tbd_0002	ENOG4105CZ8	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity)
Tbd_0003	ENOG4105C7D	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
Tbd_0006	ENOG410606W	general stress protein
Tbd_0007	ENOG4105K70	DNA-binding protein
Tbd_0011	ENOG4108RPN	Protein smg homolog
Tbd_0012	ENOG4105C79	DNA protecting protein DprA
Tbd_0014	ENOG4108Z02	Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity)
Tbd_0015	ENOG4105CAE	Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity)
Tbd_0016	ENOG4105CYJ	ribosomal RNA small subunit methyltransferase B
Tbd_0018	ENOG4105ES5	Histidine kinase
Tbd_0019	ENOG4105C1W	two component, sigma54 specific, transcriptional regulator, Fis family
Tbd_0020	ENOG4105C1A	potassium transporter peripheral membrane
Tbd_0021	ENOG4105D37	Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA (By similarity)
Tbd_0022	ENOG4105D37	Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA (By similarity)
Tbd_0023	ENOG4105WAP	TPR repeat-containing protein
Tbd_0024	ENOG4105KMG	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes (By similarity)
Tbd_0025	ENOG4108UTW	Plays a role in the regulation of phosphate uptake
Tbd_0027	ENOG4105M6F	mutator MutT protein
Tbd_0029	ENOG4105C5V	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity)
Tbd_0033	ENOG4107R2I	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation
Tbd_0035	ENOG4108Z4U	Ferredoxin
Tbd_0036	ENOG4105K63	Thioredoxin
Tbd_0037	ENOG4105C4P	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity)
Tbd_0038	ENOG4105C4P	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity)
Tbd_0039	ENOG4105VFB	Binds the 23S rRNA (By similarity)
Tbd_0040	ENOG4105D0M	Protease HtpX homolog
Tbd_0042	ENOG4105C6R	Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity)
Tbd_0044	ENOG4105CHG	glycolate oxidase (iron-sulfur subunit)
Tbd_0045	ENOG4109025	Glyoxalase Bleomycin resistance protein (Dioxygenase
Tbd_0046	ENOG4105EU8	FAD linked oxidase domain protein
Tbd_0047	ENOG4105CQB	FAD linked oxidase domain protein
Tbd_0050	ENOG4107258	Transcriptional regulator
Tbd_0057	ENOG4105D78	K07001 NTE family protein
Tbd_0059	ENOG4105E27	serine threonine protein kinase
Tbd_0060	ENOG4105CAQ	asparagine synthetase
Tbd_0061	ENOG4105CVE	Lytic murein transglycosylase
Tbd_0068	ENOG4105C5X	domain protein
Tbd_0069	ENOG41066UZ	arginase EC 3.5.3.1
Tbd_0072	ENOG4108UMR	transcriptional regulator AsnC family
Tbd_0073	ENOG4108ZGY	Transcriptional regulator (AsnC family)
Tbd_0074	ENOG4108UMR	transcriptional regulator AsnC family
Tbd_0075	ENOG4106P6N	cytochrome d1 heme region
Tbd_0076	ENOG4105Y7H	Cytochrome
Tbd_0077	ENOG4105F64	nitrite reductase
Tbd_0078	ENOG4105HEE	Binding Domain protein
Tbd_0081	ENOG4105CF3	3-Hydroxyisobutyrate dehydrogenase
Tbd_0083	ENOG41061WM	D-Alanyl-D-Alanine
Tbd_0085	ENOG4105BZU	Histidine kinase
Tbd_0088	ENOG4107QN1	sodium solute
Tbd_0089	ENOG4105DE5	Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity)
Tbd_0091	ENOG4105CJ9	Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity)
Tbd_0092	ENOG4105K5Y	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity)
Tbd_0095	ENOG4105CY0	Metallo-Beta-Lactamase
Tbd_0096	ENOG4105HDD	phospholipase
Tbd_0097	ENOG4105C0H	protease
Tbd_0099	ENOG4108IAJ	Nad-dependent epimerase dehydratase
Tbd_0101	ENOG4106HRJ	d-alanyl-d-alanine carboxypeptidase
Tbd_0102	ENOG4107MBR	17 kDa surface antigen
Tbd_0103	ENOG4108UK1	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant (By similarity)
Tbd_0104	ENOG4105D3H	Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity)
Tbd_0105	ENOG4107Z67	Catalyzes the ADP transfer to D-glycero-D-manno-heptose 1-phosphate, yielding ADP-D,D-heptose (By similarity)
Tbd_0106	ENOG4105W4M	Transport-associated protein
Tbd_0107	ENOG4105F55	Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate (By similarity)
Tbd_0108	ENOG4105CU0	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity)
Tbd_0109	ENOG4105EKE	dihydroorotase
Tbd_0110	ENOG4108V6E	Cell division protein mraZ
Tbd_0111	ENOG4105CGJ	Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity)
Tbd_0112	ENOG4105N8N	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic (By similarity)
Tbd_0113	ENOG4105CJN	penicillin-binding protein
Tbd_0114	ENOG4107EEN	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity)
Tbd_0115	ENOG4108EQQ	Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein (By similarity)
Tbd_0116	ENOG4105CPY	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity)
Tbd_0117	ENOG4105DMZ	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity)
Tbd_0118	ENOG4105CNI	cell division protein FtsW
Tbd_0119	ENOG4105DVQ	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity)
Tbd_0120	ENOG4105DFU	Cell wall formation (By similarity)
Tbd_0121	ENOG4105D4A	Cell wall formation (By similarity)
Tbd_0122	ENOG4105CPF	Cell wall formation (By similarity)
Tbd_0123	ENOG4105K7E	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly (By similarity)
Tbd_0124	ENOG4105CIT	This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity)
Tbd_0125	ENOG4105CDK	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity)
Tbd_0126	ENOG4105C7C	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity)
Tbd_0128	ENOG4105NQN	cytochrome C
Tbd_0129	ENOG41090Y2	cytochrome C
Tbd_0131	ENOG4105CI6	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving
Tbd_0135	ENOG4105DHQ	Histidine kinase
Tbd_0136	ENOG4105XJC	Two component transcriptional regulator (Winged helix family
Tbd_0140	ENOG4105E0M	Sulfatase
Tbd_0146	ENOG4105MPD	Cytochrome
Tbd_0151	ENOG4105C5H	ABC transporter
Tbd_0152	ENOG4105BZU	Histidine kinase
Tbd_0154	ENOG4108EKC	n-acetylglutamate synthase
Tbd_0155	ENOG4105QF0	Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity)
Tbd_0158	ENOG4105ECY	inositol monophosphatase
Tbd_0159	ENOG4105CV1	Transketolase (EC 2.2.1.1)
Tbd_0160	ENOG4105C17	glyceraldehyde-3-phosphate dehydrogenase
Tbd_0161	ENOG4105BZA	Phosphoglycerate kinase
Tbd_0162	ENOG4105CA9	Pyruvate kinase
Tbd_0163	ENOG4105D2N	Aldolase
Tbd_0166	ENOG4105C4R	Atp-dependent dna helicase
Tbd_0168	ENOG4105DDT	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity)
Tbd_0172	ENOG41080IJ	Diacylglycerol kinase
Tbd_0173	ENOG4105CBI	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
Tbd_0174	ENOG4108V1J	Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity)
Tbd_0176	ENOG4107QK8	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
Tbd_0177	ENOG4105KE9	The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity)
Tbd_0178	ENOG4105D43	The glycine cleavage system catalyzes the degradation of glycine (By similarity)
Tbd_0180	ENOG4105F59	Methylates ribosomal protein L11 (By similarity)
Tbd_0181	ENOG4105CER	acetyl-CoA carboxylase biotin carboxylase
Tbd_0182	ENOG4105KM4	Acetyl-CoA carboxylase, biotin carboxyl carrier protein
Tbd_0183	ENOG4108Z38	Catalyzes a trans-dehydration via an enolate intermediate (By similarity)
Tbd_0184	ENOG4107ZT5	Thiol disulfide interchange protein
Tbd_0185	ENOG4105CRE	cytochrome C
Tbd_0186	ENOG4105EBH	Required during biogenesis of c-type cytochromes (cytochrome c6 and cytochrome f) at the step of heme attachment (By similarity)
Tbd_0187	ENOG4106RE7	Cytochrome
Tbd_0188	ENOG4105WHM	Necessary for normal cell division and for the maintenance of normal septation (By similarity)
Tbd_0189	ENOG4105D52	delta-aminolevulinic acid dehydratase
Tbd_0196	ENOG4105DJQ	tetratricopeptide tpr_2 repeat protein
Tbd_0197	ENOG4105C1W	two component, sigma54 specific, transcriptional regulator, Fis family
Tbd_0198	ENOG4105BZU	Histidine kinase
Tbd_0201	ENOG4108JQC	penicillin-binding protein 1A
Tbd_0206	ENOG4105E4G	Type IV pilus
Tbd_0207	ENOG4105KHV	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity)
Tbd_0210	ENOG4107RIQ	Sulfate adenylate transferase
Tbd_0213	ENOG4105CNK	Required, probably indirectly, for the hydroxylation of 2-octaprenylphenol to 2-octaprenyl-6-hydroxy-phenol, the fourth step in ubiquinone biosynthesis (By similarity)
Tbd_0215	ENOG4105DDZ	Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity)
Tbd_0216	ENOG4105CK6	Two component transcriptional regulator (Winged helix family
Tbd_0217	ENOG4105BZU	Histidine kinase
Tbd_0219	ENOG4105CQB	FAD linked oxidase domain protein
Tbd_0220	ENOG4105CKW	Inner membrane protein yedI
Tbd_0221	ENOG4105D0I	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity)
Tbd_0222	ENOG4105CI4	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity)
Tbd_0223	ENOG41080RH	Thioredoxin
Tbd_0226	ENOG4105CU5	Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity)
Tbd_0227	ENOG4105XQ6	frataxin-like protein
Tbd_0229	ENOG4105CH7	arginosuccinase
Tbd_0231	ENOG4108NEV	two component transcriptional regulator, LytTR family
Tbd_0234	ENOG4105C3R	Methionine synthase
Tbd_0237	ENOG4105C0P	Mg chelatase subunit ChlI
Tbd_0238	ENOG4105W0Z	cytoplasmic protein
Tbd_0240	ENOG4108YZA	Nitrogen regulatory protein pii
Tbd_0241	ENOG4105BZU	Histidine kinase
Tbd_0242	ENOG4105EUJ	GTP cyclohydrolase i
Tbd_0244	ENOG4107QKZ	Ompa motb domain protein
Tbd_0246	ENOG4105CVG	Homoserine O-transsuccinylase
Tbd_0247	ENOG4105CY3	ABC transporter, permease
Tbd_0248	ENOG4105DHJ	ABC, transporter
Tbd_0254	ENOG4105CGK	Exodeoxyribonuclease III
Tbd_0255	ENOG4107QP2	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity)
Tbd_0257	ENOG4105CHT	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity)
Tbd_0258	ENOG4105C3P	Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity)
Tbd_0259	ENOG41080G2	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity)
Tbd_0260	ENOG4105DFF	Rod shape-determining protein mreb
Tbd_0263	ENOG4105CJN	penicillin-binding protein
Tbd_0264	ENOG4105CNI	cell division protein FtsW
Tbd_0266	ENOG4105DZ1	carboxypeptidase
Tbd_0267	ENOG4105F0I	Aminotransferase
Tbd_0268	ENOG4108Z43	UPF0250 protein
Tbd_0269	ENOG4108BDP	Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity)
Tbd_0270	ENOG4108I0Q	anthranilate phosphoribosyltransferase
Tbd_0272	ENOG4107ZT5	Thiol disulfide interchange protein
Tbd_0274	ENOG4105C0G	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity)
Tbd_0277	ENOG4105CJ1	ABC, transporter
Tbd_0281	ENOG4107V1M	polysaccharide export protein
Tbd_0283	ENOG4108QV3	biosynthesis protein
Tbd_0286	ENOG4105EAG	UDP-N-acetylglucosamine 2-epimerase
Tbd_0292	ENOG4105CAQ	asparagine synthetase
Tbd_0293	ENOG4105CPK	Glycosyl transferase (Group 1
Tbd_0294	ENOG4107R5M	Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity)
Tbd_0301	ENOG4107QRS	glycosyltransferase group 2 family protein
Tbd_0302	ENOG4107R5M	Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity)
Tbd_0305	ENOG4105CPK	Glycosyl transferase (Group 1
Tbd_0306	ENOG4106KS4	Sulfatase
Tbd_0313	ENOG4108MKI	Glycosyl transferase, family 2
Tbd_0315	ENOG4105D49	3-dehydroquinate synthase
Tbd_0316	ENOG4105C4Q	deoxyguanosinetriphosphate triphosphohydrolase-like protein
Tbd_0317	ENOG4105MJ2	Competence protein
Tbd_0319	ENOG4105CZF	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity)
Tbd_0320	ENOG4107EEK	Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity)
Tbd_0321	ENOG4105D3C	The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity)
Tbd_0322	ENOG4106T9E	Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity)
Tbd_0323	ENOG4105E78	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity)
Tbd_0325	ENOG4105CV4	Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) (By similarity)
Tbd_0326	ENOG4105BZ9	Cytochrome C oxidase, subunit I
Tbd_0328	ENOG4105FT1	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I (By similarity)
Tbd_0330	ENOG4107QS1	Cytochrome C Oxidase, Subunit III
Tbd_0334	ENOG4107TQK	Catalyzes the oxidation of the C8 methyl side group on heme O porphyrin ring into a formyl group (By similarity)
Tbd_0335	ENOG4105F1R	Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity)
Tbd_0341	ENOG4105D6P	C-type cytochrome. Part of the cbb3-type cytochrome c oxidase complex (By similarity)
Tbd_0342	ENOG4105C58	cytochrome c oxidase accessory protein ccog
Tbd_0345	ENOG4105DEK	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity)
Tbd_0348	ENOG4105EEX	Two component transcriptional regulator (Winged helix family
Tbd_0357	ENOG4105E02	MotA TolQ exbB proton channel
Tbd_0358	ENOG4105SG9	biopolymer transport protein, ExbD
Tbd_0368	ENOG4108HRN	Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity)
Tbd_0374	ENOG4105CRP	Part of the ABC transporter FtsEX involved in
Tbd_0375	ENOG4105CAK	Cell division ATP-binding protein ftsE
Tbd_0378	ENOG4105C1V	Peptidase, M16
Tbd_0379	ENOG4106H78	methyltransferase
Tbd_0380	ENOG4108ZEF	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity)
Tbd_0381	ENOG4105K5D	4fe-4S ferredoxin iroN-sulfur binding
Tbd_0383	ENOG4105ERD	Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity)
Tbd_0384	ENOG4105DJQ	tetratricopeptide tpr_2 repeat protein
Tbd_0385	ENOG41081V9	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein (By similarity)
Tbd_0386	ENOG4105CTR	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity)
Tbd_0387	ENOG4105C5T	Phosphoribosyl pyrophosphate synthase
Tbd_0388	ENOG4105KW6	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity)
Tbd_0389	ENOG4108ZPD	The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity)
Tbd_0390	ENOG4105C3G	gtp-binding protein
Tbd_0391	ENOG4105CGV	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity)
Tbd_0392	ENOG4105PM1	preprotein translocase subunit SecE
Tbd_0393	ENOG4105E5V	Participates in transcription elongation, termination and antitermination (By similarity)
Tbd_0394	ENOG4108UIK	This protein binds directly to 23S ribosomal RNA (By similarity)
Tbd_0395	ENOG4105C64	Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity)
Tbd_0396	ENOG4108VZM	50s ribosomal protein L10
Tbd_0397	ENOG4105KBC	Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity)
Tbd_0398	ENOG4107QIH	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
Tbd_0399	ENOG4107QR0	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
Tbd_0400	ENOG4108UKE	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity)
Tbd_0401	ENOG4108UHY	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity)
Tbd_0402	ENOG4105CEJ	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity)
Tbd_0403	ENOG4105CGV	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity)
Tbd_0404	ENOG4108Z10	Involved in the binding of tRNA to the ribosomes (By similarity)
Tbd_0405	ENOG4105EEE	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity)
Tbd_0406	ENOG4106U5A	One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity)
Tbd_0407	ENOG41080KG	One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity)
Tbd_0408	ENOG4105CFD	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
Tbd_0409	ENOG4105K7S	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity)
Tbd_0410	ENOG4105KAP	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity)
Tbd_0411	ENOG4105CKE	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity)
Tbd_0412	ENOG4108R70	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity)
Tbd_0413	ENOG41084PQ	50s ribosomal protein l29
Tbd_0414	ENOG4105K87	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal
Tbd_0415	ENOG4108UNN	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity)
Tbd_0416	ENOG4105KAR	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity)
Tbd_0417	ENOG4105CW6	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
Tbd_0418	ENOG4105VBI	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity)
Tbd_0419	ENOG4108UJY	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity)
Tbd_0420	ENOG4108R5J	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity)
Tbd_0421	ENOG4105K4C	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity)
Tbd_0422	ENOG4108RA9	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity)
Tbd_0423	ENOG4105VPB	50S ribosomal protein L30
Tbd_0424	ENOG4108UZ0	Binds to the 23S rRNA (By similarity)
Tbd_0425	ENOG4105CGG	The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity)
Tbd_0426	ENOG4105K9U	however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity)
Tbd_0427	ENOG4108Z04	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
Tbd_0428	ENOG4108UHH	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity)
Tbd_0429	ENOG4105G6W	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity)
Tbd_0430	ENOG4105CTF	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
Tbd_0431	ENOG4108ZT0	50S ribosomal protein l17
Tbd_0435	ENOG4105FE9	pseudouridine synthase
Tbd_0436	ENOG4105C5U	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity)
Tbd_0437	ENOG4107RDB	Major Facilitator
Tbd_0438	ENOG4108UUM	single-stranded DNA-binding protein
Tbd_0439	ENOG4105CHI	Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB (By similarity)
Tbd_0442	ENOG4105C9M	aspartyl-trna synthetase
Tbd_0444	ENOG4108TIT	dATP pyrophosphohydrolase
Tbd_0446	ENOG4105DZQ	phospholipase D Transphosphatidylase
Tbd_0447	ENOG4105CGZ	zinc metallopeptidase
Tbd_0448	ENOG4108Z9W	Outer membrane porin
Tbd_0451	ENOG4108UKZ	OsmC family
Tbd_0453	ENOG4108UM5	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity)
Tbd_0454	ENOG4108UJD	30S ribosomal protein S9
Tbd_0455	ENOG4105C0N	N-acetylglutamate semialdehyde dehydrogenase
Tbd_0456	ENOG4108YX9	iron--sulfur cluster insertion protein erpA
Tbd_0457	ENOG4105ED7	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling (By similarity)
Tbd_0458	ENOG4105E4C	Lytic transglycosylase catalytic
Tbd_0459	ENOG4105DA0	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity)
Tbd_0460	ENOG4105HJX	Biotin- acetyl-CoA-carboxylase ligase
Tbd_0461	ENOG4108194	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis (By similarity)
Tbd_0463	ENOG4105C4G	Synthesis of 3-octaprenyl-4-hydroxybenzoate (By similarity)
Tbd_0464	ENOG410807V	Removes the pyruvyl group from chorismate, with concomitant aromatization of the ring, to provide 4- hydroxybenzoate (4HB) for the ubiquinone pathway (By similarity)
Tbd_0468	ENOG4105CG6	trap dicarboxylate transporter dctm subunit
Tbd_0469	ENOG4105CB5	ATP-dependent DNA helicase recG
Tbd_0470	ENOG4105KME	endoribonuclease L-psp
Tbd_0471	ENOG4105CWR	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity)
Tbd_0472	ENOG4105VFG	Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity)
Tbd_0473	ENOG4108UHA	Essential for recycling GMP and indirectly, cGMP (By similarity)
Tbd_0474	ENOG4105DSJ	YicC domain protein
Tbd_0475	ENOG4107WDG	serine threonine protein kinase
Tbd_0476	ENOG4108ZF3	Phosphatase
Tbd_0477	ENOG4105ED0	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity)
Tbd_0478	ENOG4108V82	Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity)
Tbd_0479	ENOG4105CSA	Coproporphyrinogen iii oxidase
Tbd_0481	ENOG4105EUJ	GTP cyclohydrolase i
Tbd_0487	ENOG4105BZU	Histidine kinase
Tbd_0488	ENOG4105EYA	deoxyribonuclease
Tbd_0489	ENOG4108MN8	Membrane
Tbd_0490	ENOG4107QX8	SPFH domain, Band 7 family protein
Tbd_0492	ENOG4105KJM	monovalent cation h antiporter subunit g
Tbd_0493	ENOG4105W4C	monovalent cation H antiporter subunit F
Tbd_0494	ENOG4105SC1	monovalent cation H antiporter subunit E
Tbd_0495	ENOG4107R4Z	monovalent cation h antiporter subunit d
Tbd_0496	ENOG4108ZE9	Monovalent cation H antiporter subunit C
Tbd_0497	ENOG4105D65	subunit l
Tbd_0499	ENOG4105D8X	mechanosensitive ion channel
Tbd_0500	ENOG4105C3N	Participates in control of cell volume in low-osmolarity conditions (By similarity)
Tbd_0501	ENOG4105FEU	K -dependent Na -Ca exchanger
Tbd_0502	ENOG4105C52	Atpase, p-type (Transporting), had superfamily, subfamily ic
Tbd_0503	ENOG4105CE6	Adenylation and deadenylation of glutamate--ammonia ligase (By similarity)
Tbd_0504	ENOG4108IQF	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity)
Tbd_0509	ENOG4105VEJ	Heat shock protein
Tbd_0512	ENOG4105D1U	peptidase U62 modulator of DNA gyrase
Tbd_0514	ENOG4105E99	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity)
Tbd_0515	ENOG4107QMP	dna polymerase iii subunits gamma and tau
Tbd_0516	ENOG4105KDX	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity)
Tbd_0517	ENOG4105F3K	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity)
Tbd_0518	ENOG4107QTF	adenylosuccinate lyase
Tbd_0519	ENOG4107QR8	Thioredoxin
Tbd_0522	ENOG4105CUZ	uba thif-type nad fad binding protein
Tbd_0526	ENOG4108UMA	3-octaprenyl-4-hydroxybenzoate carboxy-lyase
Tbd_0529	ENOG4105C21	Displays ATPase and GTPase activities (By similarity)
Tbd_0530	ENOG4105D1C	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion (By similarity)
Tbd_0531	ENOG4107RM2	PTS IIA-like nitrogen-regulatory protein PtsN
Tbd_0532	ENOG41080QH	sigma 54 modulation protein ribosomal protein S30EA
Tbd_0533	ENOG4105DTW	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity)
Tbd_0534	ENOG4108IUZ	ABC transporter
Tbd_0535	ENOG4105WI0	lipopolysaccharide transport periplasmic protein lptA
Tbd_0537	ENOG4108Z4R	3-deoxy-d-manno-octulosonate 8-phosphate phosphatase
Tbd_0538	ENOG4105C2X	Arabinose 5-phosphate isomerase
Tbd_0547	ENOG4107QHF	type ii secretion system protein e
Tbd_0549	ENOG4105GVR	general secretion pathway protein D
Tbd_0553	ENOG4105CIM	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity)
Tbd_0555	ENOG4105FAE	von Willebrand factor, type A
Tbd_0562	ENOG4108VKQ	nitriC oxide reductase
Tbd_0564	ENOG41088H4	Diheme cytochrome SoxA (Sulfur oxidation)
Tbd_0568	ENOG4105ERG	peptidase m48, ste24p
Tbd_0569	ENOG4108YXW	Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity)
Tbd_0570	ENOG4105DB1	molybdopterin oxidoreductase
Tbd_0571	ENOG4105QA4	4Fe-4S Ferredoxin, iron-sulfur binding domain protein
Tbd_0572	ENOG4108KDI	dmso reductase anchor subunit
Tbd_0573	ENOG41082J7	Rhodanese domain protein
Tbd_0574	ENOG41082K8	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Interacts with IscS and stimulates its activity. Then, accepts a sulfur from IscS and transfers it in turn to TusD (By similarity)
Tbd_0575	ENOG4108ZCA	Inherit from COG: pyridine nucleotide-disulfide oxidoreductase
Tbd_0577	ENOG4105CA4	amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity)
Tbd_0579	ENOG4105MYG	DNA polymerase iii, chi subunit
Tbd_0580	ENOG4105BZ6	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity)
Tbd_0583	ENOG4105ED9	Protein of unknown function (DUF455)
Tbd_0585	ENOG4105EZE	Cupin 4 family protein
Tbd_0586	ENOG4108YXY	alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
Tbd_0587	ENOG4108YZY	peptidylprolyl cis-trans isomerase
Tbd_0588	ENOG4107QM9	Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (By similarity)
Tbd_0589	ENOG4105D3U	Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity)
Tbd_0590	ENOG4108UGX	Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity)
Tbd_0591	ENOG4105C55	Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs
Tbd_0593	ENOG4105HSZ	Cytoskeletal protein that is involved in cell-shape control through regulation of the length of the long axis (By similarity)
Tbd_0594	ENOG4105C4E	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity)
Tbd_0595	ENOG4105CUT	histidyl-tRNA synthetase
Tbd_0597	ENOG4105CNE	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity)
Tbd_0598	ENOG4105DKZ	GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity)
Tbd_0602	ENOG4105C1N	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity)
Tbd_0603	ENOG4107QJR	hflk protein
Tbd_0604	ENOG4105EPW	hflc protein
Tbd_0606	ENOG4105C49	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine (By similarity)
Tbd_0607	ENOG4105C91	Plays an important role in the de novo pathway of purine nucleotide biosynthesis
Tbd_0608	ENOG4105C40	3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity)
Tbd_0609	ENOG4105C2N	RNA methyltransferase TrmH family group 3
Tbd_0612	ENOG4105DDY	UPF0142 protein ycaO
Tbd_0615	ENOG4105C2N	RNA methyltransferase TrmH family group 3
Tbd_0616	ENOG4105BZU	Histidine kinase
Tbd_0617	ENOG4105CF9	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation (By similarity)
Tbd_0619	ENOG4105C8D	Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity)
Tbd_0620	ENOG4105CXR	Phospho-2-dehydro-3-deoxyoctonate aldolase
Tbd_0621	ENOG4105C70	Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity)
Tbd_0622	ENOG4105XX3	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic (By similarity)
Tbd_0624	ENOG4105C77	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity)
Tbd_0625	ENOG4105C3Y	UTP-glucose-1-phosphate uridylyltransferase
Tbd_0626	ENOG4105DR1	Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity)
Tbd_0629	ENOG4107QIK	phosphoribosylformylglycinamidine synthase
Tbd_0630	ENOG4105CCA	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle (By similarity)
Tbd_0635	ENOG4105D4P	Coproporphyrinogen iii oxidase
Tbd_0636	ENOG4105BZU	Histidine kinase
Tbd_0643	ENOG4105EUH	cytochrome C oxidase, cbb3-type, subunit i
Tbd_0644	ENOG4105DCF	alanine dehydrogenase
Tbd_0645	ENOG4107QYT	Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor (By similarity)
Tbd_0646	ENOG4105CK2	sodium dicarboxylate symporter
Tbd_0647	ENOG4105DZ1	carboxypeptidase
Tbd_0652	ENOG4107QN2	dihydrolipoyl dehydrogenase
Tbd_0655	ENOG4108JYK	Dehydrogenase
Tbd_0656	ENOG4105BZ6	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity)
Tbd_0658	ENOG4105D3G	Pseudouridine synthase
Tbd_0659	ENOG4108Z7T	Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity)
Tbd_0660	ENOG4105C8Q	Methyl-accepting chemotaxis
Tbd_0662	ENOG4105C7K	acetolactate synthase
Tbd_0663	ENOG4108302	MgtC SapB transporter
Tbd_0665	ENOG4105CW3	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity)
Tbd_0666	ENOG4105D10	5-enolpyruvylshikimate-3-phosphate phospholyase
Tbd_0668	ENOG4105DFA	alanine racemase domain protein
Tbd_0670	ENOG4105WH1	Two component transcriptional regulator luxr family
Tbd_0671	ENOG4105F8J	Adenylate Guanylate cyclase
Tbd_0672	ENOG4105VDM	plasmid maintenance system antidote protein, xre family
Tbd_0674	ENOG4105C57	major facilitator superfamily
Tbd_0676	ENOG4105DAN	ATP-dependent protease
Tbd_0679	ENOG4105VEQ	Cold shock protein
Tbd_0680	ENOG4108VWS	Yaeq family
Tbd_0683	ENOG4105C72	UPF0176 protein
Tbd_0684	ENOG4105CV6	ABC transporter, permease
Tbd_0685	ENOG4108I0Y	(ABC) transporter
Tbd_0686	ENOG4108UJV	acyl-CoA thioesterase i
Tbd_0687	ENOG4105K5B	UPF0225 protein
Tbd_0689	ENOG4105CN0	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity)
Tbd_0690	ENOG4107S75	HAD-superfamily hydrolase subfamily IA variant 3
Tbd_0691	ENOG4108V7X	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
Tbd_0693	ENOG4105C62	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity)
Tbd_0694	ENOG4105K77	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity)
Tbd_0695	ENOG4105D0T	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity)
Tbd_0696	ENOG4105KG7	Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity)
Tbd_0697	ENOG4107QHU	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity)
Tbd_0698	ENOG4105CHV	Transcription elongation factor NusA
Tbd_0699	ENOG4105K7D	Required for maturation of 30S ribosomal subunits (By similarity)
Tbd_0701	ENOG4105CII	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity)
Tbd_0702	ENOG41069HH	4-oxalocrotonate tautomerase
Tbd_0703	ENOG4105E50	uracil-dna glycosylase
Tbd_0704	ENOG4108UQY	Iron-storage protein
Tbd_0706	ENOG41079HR	Phosphate-Selective Porin O and P
Tbd_0709	ENOG4106I92	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity)
Tbd_0717	ENOG4105CU5	Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity)
Tbd_0719	ENOG4105C6X	Major Facilitator
Tbd_0722	ENOG4105GAV	receptor
Tbd_0723	ENOG4107SJW	iron permease, FTR1
Tbd_0726	ENOG4105PGM	cation diffusion facilitator family transporter
Tbd_0727	ENOG4107QPA	Cleaves GlcNAc linked beta-1,4 to MurNAc tripeptides (By similarity)
Tbd_0728	ENOG4105KJV	Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity)
Tbd_0730	ENOG4105C1W	two component, sigma54 specific, transcriptional regulator, Fis family
Tbd_0732	ENOG4105DTW	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity)
Tbd_0734	ENOG4107EXU	Short-chain dehydrogenase reductase Sdr
Tbd_0739	ENOG4108JJ7	ABC transporter
Tbd_0740	ENOG4107R5M	Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity)
Tbd_0741	ENOG4108ZI0	d,d-heptose 1,7-bisphosphate phosphatase
Tbd_0742	ENOG4105DKP	glycosyl transferase, family 9
Tbd_0747	ENOG4108JW7	Maf-like protein
Tbd_0749	ENOG4105EZM	VWA-like domain (DUF2201)
Tbd_0750	ENOG4105F4C	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress (By similarity)
Tbd_0752	ENOG4107QHF	type ii secretion system protein e
Tbd_0754	ENOG4105KHS	type IV fimbrial pilin protein
Tbd_0768	ENOG4105CHM	Aminotransferase
Tbd_0770	ENOG4107QSV	RmuC domain protein
Tbd_0774	ENOG4108Z18	K06886 hemoglobin
Tbd_0775	ENOG4107SPG	Catalyzes two reactions the first one is the production of beta-formyl glycinamide ribonucleotide (GAR) from formate, ATP and beta GAR
Tbd_0777	ENOG4108UGV	hypoxanthine phosphoribosyltransferase
Tbd_0778	ENOG4107RHB	Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S- adenosylmethionine. Has broad substrate specificity with 6- aminopurine nucleosides as preferred substrates (By similarity)
Tbd_0779	ENOG4105I08	Pseudouridine synthase
Tbd_0780	ENOG4108RBJ	Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity)
Tbd_0783	ENOG4105E1P	Modifies, by uridylylation or deuridylylation the PII (GlnB) regulatory protein (By similarity)
Tbd_0784	ENOG4105CA1	Removes the N-terminal methionine from nascent proteins (By similarity)
Tbd_0785	ENOG4105CE9	30S ribosomal protein S2
Tbd_0786	ENOG4105CU7	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity)
Tbd_0787	ENOG4105C41	Catalyzes the reversible phosphorylation of UMP to UDP (By similarity)
Tbd_0788	ENOG4108VCV	Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity)
Tbd_0789	ENOG4105CR3	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity)
Tbd_0790	ENOG4105KNE	Phosphatidate cytidylyltransferase
Tbd_0791	ENOG4105CEA	Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity)
Tbd_0793	ENOG4105E1Z	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
Tbd_0795	ENOG4105D7M	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity)
Tbd_0796	ENOG4108YXN	Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity)
Tbd_0797	ENOG4105DAF	Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity)
Tbd_0798	ENOG4105D0V	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity)
Tbd_0799	ENOG4108UH2	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity)
Tbd_0805	ENOG4105CMV	Succinyl-CoA synthetase subunit beta
Tbd_0806	ENOG4105CH8	Succinyl-CoA ligase ADP-forming subunit alpha
Tbd_0807	ENOG4105C4K	Nad synthetase
Tbd_0808	ENOG4108YZA	Nitrogen regulatory protein pii
Tbd_0809	ENOG4106SNF	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
Tbd_0810	ENOG4105C34	Pseudouridine synthase
Tbd_0811	ENOG4105DBW	Multi-copper polyphenol oxidoreductase laccase
Tbd_0813	ENOG4108RTV	Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity)
Tbd_0814	ENOG4105D18	nicotinate-nucleotide pyrophosphorylase
Tbd_0815	ENOG4105C2Z	ATP-dependent CLP protease ATP-binding subunit
Tbd_0818	ENOG4108ZJD	Protein of unknown function (DUF1109)
Tbd_0822	ENOG4108VKQ	nitriC oxide reductase
Tbd_0823	ENOG4105DSQ	Nitric oxide reductase
Tbd_0824	ENOG4105GMT	ATPase associated with various cellular activities aaa_5
Tbd_0825	ENOG4105FAE	von Willebrand factor, type A
Tbd_0827	ENOG4105DKD	Incises the DNA at the 3' side of a lesion during nucleotide excision repair. Incises the DNA farther away from the lesion than UvrC. Not able to incise the 5' site of a lesion. When a lesion remains because UvrC is not able to induce the 3' incision, Cho incises the DNA. Then UvrC makes the 5' incision. The combined action of Cho and UvrC broadens the substrate range of nucleotide excision repair (By similarity)
Tbd_0828	ENOG4105C0B	DNA polymerase III (alpha subunit)
Tbd_0831	ENOG4107QRI	Phosphoketolase
Tbd_0832	ENOG4105C6H	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity)
Tbd_0835	ENOG4105CV2	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates (By similarity)
Tbd_0836	ENOG4105E26	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity)
Tbd_0837	ENOG4108K5P	(LipO)protein
Tbd_0838	ENOG4105DG1	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity)
Tbd_0839	ENOG4107Y3D	HAD-superfamily hydrolase subfamily IA variant 3
Tbd_0842	ENOG4105CHM	Aminotransferase
Tbd_0843	ENOG4105D6E	homoserine dehydrogenase
Tbd_0845	ENOG4108RG0	uracil-dna glycosylase
Tbd_0846	ENOG4108U78	Glutathione S-transferase
Tbd_0847	ENOG4108HW8	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity)
Tbd_0850	ENOG4105CX6	glutaminyL-tRNA synthetase
Tbd_0851	ENOG4105CCJ	Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity)
Tbd_0853	ENOG4108R99	pseudouridine synthase
Tbd_0855	ENOG4105VEQ	Cold shock protein
Tbd_0857	ENOG4105DRH	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity)
Tbd_0858	ENOG4105C0B	DNA polymerase III (alpha subunit)
Tbd_0859	ENOG4105VSY	K01512 acylphosphatase EC 3.6.1.7
Tbd_0860	ENOG4105CKH	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity)
Tbd_0863	ENOG4105EAH	synthase
Tbd_0864	ENOG4105KK9	This protein binds to 23S rRNA in the presence of protein L20 (By similarity)
Tbd_0865	ENOG4105K46	50S ribosomal protein l27
Tbd_0866	ENOG4105C9R	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
Tbd_0868	ENOG4105FAE	von Willebrand factor, type A
Tbd_0874	ENOG4107RIQ	Sulfate adenylate transferase
Tbd_0876	ENOG4105C1M	carbamoyl-phosphate synthetase glutamine chain
Tbd_0877	ENOG4108WIW	Aspartyl protease
Tbd_0878	ENOG4105DZA	Converts GTP to 7,8-dihydroneopterin triphosphate (By similarity)
Tbd_0879	ENOG4105C2V	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity)
Tbd_0881	ENOG41082UU	Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity)
Tbd_0891	ENOG4107QM5	aconitate hydratase
Tbd_0893	ENOG4105CRK	lysyL-tRNA synthetase
Tbd_0896	ENOG4105C9U	ATP-dependent DNA helicase RecQ
Tbd_0899	ENOG4105CD8	aminopeptidase N
Tbd_0903	ENOG4105BZU	Histidine kinase
Tbd_0906	ENOG4108Z7T	Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity)
Tbd_0909	ENOG4105CHI	Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB (By similarity)
Tbd_0918	ENOG4105QN4	diheme cytochrome
Tbd_0921	ENOG4105CG1	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity)
Tbd_0922	ENOG4107PU6	Membrane
Tbd_0924	ENOG4105H9W	Short-chain dehydrogenase reductase Sdr
Tbd_0933	ENOG4105C0D	helicase
Tbd_0936	ENOG4107QMH	DNA methylase
Tbd_0945	ENOG4108VXP	Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity)
Tbd_0946	ENOG4107RFD	Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity)
Tbd_0947	ENOG4105D6T	Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity)
Tbd_0948	ENOG4105C24	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
Tbd_0949	ENOG4107QM1	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity)
Tbd_0950	ENOG4108JQ1	Dehydrogenase
Tbd_0952	ENOG4105CIH	Imidazole acetol-phosphate transaminase
Tbd_0954	ENOG4105CMY	5-enolpyruvylshikimate-3-phosphate synthase
Tbd_0955	ENOG4105CAT	Cytidine monophosphate kinase
Tbd_0956	ENOG4105CAV	thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity)
Tbd_0957	ENOG41080YA	This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity)
Tbd_0959	ENOG4105CFV	Tetratricopeptide repeat protein
Tbd_0960	ENOG4106EG9	Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) (By similarity)
Tbd_0961	ENOG4105C6Y	Udp-glucose 6-dehydrogenase
Tbd_0962	ENOG4105DW0	Catalyzes the ADP transfer to D-glycero-D-manno-heptose 1-phosphate, yielding ADP-D,D-heptose (By similarity)
Tbd_0963	ENOG4105CUI	Catalyzes the interconversion between ADP-D-glycero- beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose (By similarity)
Tbd_0964	ENOG4105C6T	cysteine synthase
Tbd_0965	ENOG4105DNJ	May play a role in the repair of endogenous alkylation damage (By similarity)
Tbd_0968	ENOG4105C8A	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP (By similarity)
Tbd_0969	ENOG4105CFH	Aspartokinase
Tbd_0970	ENOG4105BZT	Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity)
Tbd_0974	ENOG4107QP8	phosphohexose isomerase
Tbd_0975	ENOG4108YZY	peptidylprolyl cis-trans isomerase
Tbd_0982	ENOG4105D0M	Protease HtpX homolog
Tbd_0983	ENOG4105F8J	Adenylate Guanylate cyclase
Tbd_0984	ENOG4107YM4	Beta-lactamase domain-containing protein
Tbd_0987	ENOG4105BZU	Histidine kinase
Tbd_0990	ENOG4107QKW	extracellular solute-binding protein family 1
Tbd_0992	ENOG4107TT5	NLP P60 protein
Tbd_0995	ENOG4105BZU	Histidine kinase
Tbd_0997	ENOG4105DVT	helicase
Tbd_0999	ENOG4108YXY	alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
Tbd_1000	ENOG4108DG9	Smr protein MutS2
Tbd_1001	ENOG4105C3M	thioredoxin reductase
Tbd_1002	ENOG4105CNU	cell division protein FtsK
Tbd_1003	ENOG4105CE5	Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity)
Tbd_1004	ENOG4108UH8	Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity)
Tbd_1006	ENOG4105BZU	Histidine kinase
Tbd_1007	ENOG4105C22	threonyL-tRNA synthetase
Tbd_1008	ENOG4108UUX	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity)
Tbd_1009	ENOG4105VJV	50s ribosomal protein L35
Tbd_1010	ENOG4108YZX	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity)
Tbd_1011	ENOG4105CSS	phenylalanyl-tRNA synthetase (alpha subunit)
Tbd_1012	ENOG4105C6A	phenylalanyl-tRNA synthetase (beta subunit)
Tbd_1013	ENOG4108ZUF	This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity)
Tbd_1015	ENOG4105CK4	Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity)
Tbd_1019	ENOG4105CNG	UPF0061 protein
Tbd_1020	ENOG41067HS	methyltransferase
Tbd_1023	ENOG4105CM1	Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity)
Tbd_1024	ENOG4105FNP	Molybdopterin-guanine dinucleotide biosynthesis protein b
Tbd_1025	ENOG4105CVM	Molybdenum cofactor synthesis domain protein
Tbd_1027	ENOG4108ZAF	Molybdopterin
Tbd_1029	ENOG4105DS1	cytochrome b561
Tbd_1032	ENOG4108YYC	ycei family
Tbd_1033	ENOG4105CFP	Peptidase U32
Tbd_1034	ENOG4105F4R	Transcriptional regulator mode
Tbd_1036	ENOG4107Z6W	Protein CrcB homolog
Tbd_1042	ENOG4105BZU	Histidine kinase
Tbd_1044	ENOG4105DH2	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group (By similarity)
Tbd_1046	ENOG4105C9X	ppx gppa phosphatase
Tbd_1047	ENOG4105CV9	cyclopropane-fatty-acyl-phospholipid synthase
Tbd_1051	ENOG4105CQX	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity)
Tbd_1056	ENOG4108VGI	doxx family
Tbd_1059	ENOG4105DHI	Methyltransferase
Tbd_1061	ENOG4108NJZ	Sensory box GGDEF EAL domain protein
Tbd_1072	ENOG4107STQ	Multicopper oxidase
Tbd_1076	ENOG4105DTA	methyltransferase
Tbd_1077	ENOG4105CB5	ATP-dependent DNA helicase recG
Tbd_1078	ENOG4105CJX	Molecular chaperone. Has ATPase activity (By similarity)
Tbd_1080	ENOG4107V8I	Glycosyl transferases group 1
Tbd_1082	ENOG4107QWP	ABC-2 type transporter
Tbd_1083	ENOG4105CJ1	ABC, transporter
Tbd_1085	ENOG4105CUU	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity)
Tbd_1087	ENOG410902C	phosphohistidine phosphatase, SixA
Tbd_1088	ENOG4105C1F	The M ring may be actively involved in energy transduction (By similarity)
Tbd_1089	ENOG4105CS3	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity)
Tbd_1091	ENOG4108JIR	Flagellum-specific ATP synthase
Tbd_1095	ENOG4105CN7	Flagellar biosynthetic protein FliP
Tbd_1096	ENOG4105VS8	Flagellar biosynthetic protein fliq
Tbd_1097	ENOG4105D19	Role in flagellar biosynthesis (By similarity)
Tbd_1098	ENOG4105CDP	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity)
Tbd_1099	ENOG4105GJM	(LipO)protein
Tbd_1100	ENOG4105Q2H	domain protein
Tbd_1101	ENOG4105C1J	atp-dependent rna helicase
Tbd_1103	ENOG4108RW0	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity)
Tbd_1104	ENOG4105CJJ	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity)
Tbd_1105	ENOG4105E0X	reductase
Tbd_1107	ENOG4105CHG	glycolate oxidase (iron-sulfur subunit)
Tbd_1109	ENOG4105CV9	cyclopropane-fatty-acyl-phospholipid synthase
Tbd_1112	ENOG4105EUB	pirin domain protein
Tbd_1115	ENOG4105EN6	Membrane
Tbd_1116	ENOG4105CC0	LysR family Transcriptional regulator
Tbd_1117	ENOG4108V3G	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity)
Tbd_1118	ENOG4105EUB	pirin domain protein
Tbd_1120	ENOG4105CGT	Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity)
Tbd_1121	ENOG4105CVJ	phosphoglycerate mutase
Tbd_1122	ENOG4105JKQ	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity)
Tbd_1123	ENOG41090R7	Ferric uptake
Tbd_1124	ENOG4105YRI	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity)
Tbd_1125	ENOG4105DUK	Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity)
Tbd_1128	ENOG4105CU6	carbamoyl-phosphate synthetase ammonia chain
Tbd_1129	ENOG4108UKH	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity)
Tbd_1131	ENOG4105HBR	Rna-binding protein
Tbd_1132	ENOG4105F7M	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit (By similarity)
Tbd_1133	ENOG4105C3H	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity)
Tbd_1134	ENOG4105EEI	dihydropteroate synthase
Tbd_1135	ENOG4107QJF	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity)
Tbd_1136	ENOG4107QMV	Part of the ABC transporter complex PstSACB involved in phosphate import (By similarity)
Tbd_1137	ENOG4105C8U	phosphate abc transporter
Tbd_1138	ENOG4105E2Z	phosphate ABC transporter (Permease
Tbd_1139	ENOG4105BZY	Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity)
Tbd_1140	ENOG4105CP7	Triose-phosphate isomerase
Tbd_1141	ENOG4107EJC	Preprotein translocase subunit SecG
Tbd_1142	ENOG4105KWU	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
Tbd_1143	ENOG4105ES3	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
Tbd_1144	ENOG4105CYU	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
Tbd_1145	ENOG4105CQV	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
Tbd_1148	ENOG4108IEH	NADH dehydrogenase subunit g
Tbd_1149	ENOG4105CMZ	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone (By similarity)
Tbd_1150	ENOG4105P3U	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
Tbd_1151	ENOG4105DF2	NADH dehydrogenase subunit j
Tbd_1152	ENOG4105M5H	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
Tbd_1154	ENOG4105C8S	subunit m
Tbd_1155	ENOG4105CNR	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
Tbd_1159	ENOG4105D86	that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity)
Tbd_1160	ENOG4105ECY	inositol monophosphatase
Tbd_1161	ENOG4105CVS	RNA methyltransferase TrmH family, group 1
Tbd_1163	ENOG4108ZF1	Transcriptional regulator, BadM Rrf2 family
Tbd_1164	ENOG4105C3J	Cysteine desulfurase
Tbd_1165	ENOG4107XTC	May be involved in the formation or repair of Fe-S clusters present in iron-sulfur proteins
Tbd_1166	ENOG4108Z4V	iron-sulfur cluster assembly
Tbd_1168	ENOG4105C9I	Chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Has a low intrinsic ATPase activity which is markedly stimulated by HscB
Tbd_1169	ENOG4108ZIT	Ferredoxin, 2FE-2S
Tbd_1170	ENOG4105WVQ	Fe-S assembly protein IscX
Tbd_1173	ENOG4105C9C	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity)
Tbd_1174	ENOG4107RTM	4-alpha-glucanotransferase (EC 2.4.1.25)
Tbd_1175	ENOG4107QQ4	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity)
Tbd_1177	ENOG4105D7B	Flagellar biosynthesis protein flha
Tbd_1178	ENOG4105FZW	flagellar biosynthesis regulator FlhF
Tbd_1180	ENOG4105DN4	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity)
Tbd_1181	ENOG4105C6K	Malic enzyme
Tbd_1183	ENOG4105N1I	succinate dehydrogenase, hydrophobic membrane anchor protein
Tbd_1184	ENOG4105C00	Succinate dehydrogenase (Flavoprotein subunit)
Tbd_1185	ENOG4105E33	succinate dehydrogenase
Tbd_1186	ENOG4105Y75	tpr repeat protein
Tbd_1187	ENOG4105BZN	citrate synthase
Tbd_1188	ENOG4105C7P	2-oxoglutarate dehydrogenase, E1
Tbd_1189	ENOG4105C7S	Dehydrogenase
Tbd_1190	ENOG4105DHJ	ABC, transporter
Tbd_1191	ENOG4105BZU	Histidine kinase
Tbd_1193	ENOG4105BZU	Histidine kinase
Tbd_1195	ENOG4108UVJ	appr-1-p processing domain protein
Tbd_1200	ENOG4105CPC	Aldo Keto reductase
Tbd_1216	ENOG4108Z6B	deaminase
Tbd_1219	ENOG4105ERG	peptidase m48, ste24p
Tbd_1220	ENOG4105DMJ	Catalyzes the transfer of an acetyl group from acetyl- CoA to tetrahydrodipicolinate (By similarity)
Tbd_1222	ENOG4105DFI	Membrane
Tbd_1226	ENOG4107S5T	Carbohydrate kinase
Tbd_1227	ENOG4107YRI	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) (By similarity)
Tbd_1229	ENOG4105CGR	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity)
Tbd_1230	ENOG4105CHQ	Murein-degrading enzyme that degrades murein glycan strands and insoluble, high-molecular weight murein sacculi, with the concomitant formation of a 1,6-anhydromuramoyl product. Lytic transglycosylases (LTs) play an integral role in the metabolism of the peptidoglycan (PG) sacculus. Their lytic action creates space within the PG sacculus to allow for its expansion as well as for the insertion of various structures such as secretion systems and flagella (By similarity)
Tbd_1232	ENOG4105CYN	Serine protein kinase
Tbd_1233	ENOG4106AKX	UPF0229 protein
Tbd_1234	ENOG4105ED1	spovr family
Tbd_1236	ENOG4105KAE	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation (By similarity)
Tbd_1237	ENOG4105C2Z	ATP-dependent CLP protease ATP-binding subunit
Tbd_1240	ENOG4105GEH	Functions in complex with FlhC as a master transcriptional regulator that regulates transcription of several flagellar and non-flagellar operons by binding to their promoter region. Activates expression of class 2 flagellar genes, including fliA, which is a flagellum-specific sigma factor that turns on the class 3 genes. Also regulates genes whose products function in a variety of physiological pathways (By similarity)
Tbd_1241	ENOG4106CIA	Functions in complex with FlhD as a master transcriptional regulator that regulates transcription of several flagellar and non-flagellar operons by binding to their promoter region
Tbd_1243	ENOG4107RD7	Flagellar Motor Protein, MotA
Tbd_1244	ENOG4105ER2	Ompa motb domain protein
Tbd_1245	ENOG4105D00	flagellar biosynthetic protein flhB
Tbd_1246	ENOG4105D7B	Flagellar biosynthesis protein flha
Tbd_1247	ENOG4105FZW	flagellar biosynthesis regulator FlhF
Tbd_1249	ENOG4105DN4	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity)
Tbd_1250	ENOG4105E14	MotA TolQ exbB proton channel
Tbd_1251	ENOG4106VK6	Flagellar motor protein
Tbd_1252	ENOG4105C6P	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity)
Tbd_1253	ENOG4108ZCA	Inherit from COG: pyridine nucleotide-disulfide oxidoreductase
Tbd_1254	ENOG41082K8	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Interacts with IscS and stimulates its activity. Then, accepts a sulfur from IscS and transfers it in turn to TusD (By similarity)
Tbd_1257	ENOG4105K8I	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity)
Tbd_1258	ENOG4105FE9	pseudouridine synthase
Tbd_1266	ENOG4105CHI	Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB (By similarity)
Tbd_1268	ENOG4105BZU	Histidine kinase
Tbd_1269	ENOG4105BZU	Histidine kinase
Tbd_1271	ENOG4105C9Y	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity)
Tbd_1273	ENOG4108JJ7	ABC transporter
Tbd_1276	ENOG4108QDE	fad dependent oxidoreductase
Tbd_1277	ENOG4105FSR	swimming returnes to normal when residues 206-207 are both mutated to Ala. Overexpression also leads to a reduction in flagellar abundance and a 20-fold increase in c-di- GMP levels in vivo. Required for aminoglycoside-mediated induction of biofilm formation, it also plays a lesser role in biofilm production in response to other classes of translation inhibitors. The c-di-GMP produced by this enzyme up-regulates poly-GlcNAc production as well as the biofilm synthesis protein PgaD, although c-di-GMP is probably not the main inducing principle. Cyclic-di- GMP is a second messenger which controls cell surface-associated traits in bacteria
Tbd_1280	ENOG4105C3J	Cysteine desulfurase
Tbd_1282	ENOG4107TPS	domain protein
Tbd_1283	ENOG4108S6J	ABC transporter, periplasmic molybdate-binding protein
Tbd_1284	ENOG4105E0C	molybdate abc transporter
Tbd_1285	ENOG4105CGB	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system (By similarity)
Tbd_1287	ENOG4105DPZ	Two component transcriptional regulator (Winged helix family
Tbd_1288	ENOG4105E0F	Histidine kinase
Tbd_1289	ENOG4105BZU	Histidine kinase
Tbd_1292	ENOG4105CGH	5'-nucleotidase
Tbd_1293	ENOG4108VAU	general secretion pathway protein G
Tbd_1295	ENOG4107QHF	type ii secretion system protein e
Tbd_1300	ENOG4105GVR	general secretion pathway protein D
Tbd_1304	ENOG4105E2V	Glycosyltransferase 36
Tbd_1305	ENOG4105E5G	Alpha beta hydrolase fold
Tbd_1309	ENOG4105CY1	sulfite reductase, dissimilatory-type alpha subunit
Tbd_1311	ENOG4105DJ9	glucan biosynthesis protein
Tbd_1312	ENOG4105C3A	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs) (By similarity)
Tbd_1318	ENOG4108IYS	Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity)
Tbd_1324	ENOG4105E3B	Multicopper oxidase
Tbd_1333	ENOG4108IJF	Heavy metal efflux pump, CzcA
Tbd_1334	ENOG4105EP1	Efflux transporter rnd family, mfp subunit
Tbd_1337	ENOG4105KK4	UPF0060 membrane protein
Tbd_1341	ENOG4107QN2	dihydrolipoyl dehydrogenase
Tbd_1356	ENOG4105ENJ	RND efflux system, outer membrane lipoprotein
Tbd_1359	ENOG4105D6C	Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity)
Tbd_1361	ENOG4105D0S	secretion protein (HlyD
Tbd_1363	ENOG4105C1N	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity)
Tbd_1366	ENOG4105BZU	Histidine kinase
Tbd_1369	ENOG4105CY1	sulfite reductase, dissimilatory-type alpha subunit
Tbd_1370	ENOG4107Y70	Heat shock protein
Tbd_1375	ENOG4105DPX	Hydrogenase, large subunit
Tbd_1378	ENOG4105E3S	small subunit
Tbd_1380	ENOG4108USZ	hydrogenase
Tbd_1381	ENOG41083WG	hydrogenase assembly chaperone
Tbd_1382	ENOG4105WMM	Probably plays a role in a hydrogenase nickel cofactor insertion step (By similarity)
Tbd_1384	ENOG4105CQS	hydrogenase expression formation protein HypD
Tbd_1390	ENOG4105HEE	Binding Domain protein
Tbd_1391	ENOG4105DH4	Periplasmic copper-binding protein
Tbd_1392	ENOG4105CIG	ABC transporter
Tbd_1393	ENOG4108T0W	nitrous oxide maturation protein NosY
Tbd_1399	ENOG4105WH1	Two component transcriptional regulator luxr family
Tbd_1400	ENOG4105BZU	Histidine kinase
Tbd_1402	ENOG4105DQQ	Major facilitator superfamily MFS_1
Tbd_1403	ENOG4105CRU	nitrate reductase, alpha subunit
Tbd_1404	ENOG4108IUE	nitrate reductase beta subunit
Tbd_1405	ENOG4105R3A	Nitrate reductase
Tbd_1406	ENOG4105D0D	Nitrate reductase 2, gamma subunit
Tbd_1407	ENOG4107SA8	fad-dependent pyridine nucleotide-disulfide oxidoreductase
Tbd_1408	ENOG4108Z0T	Part of a sulfur-relay system (By similarity)
Tbd_1410	ENOG4105CFB	Gamma-glutamyltranspeptidase (EC 2.3.2.2)
Tbd_1411	ENOG4105BZU	Histidine kinase
Tbd_1412	ENOG4105D6C	Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity)
Tbd_1413	ENOG4105D6C	Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity)
Tbd_1416	ENOG4105ENJ	RND efflux system, outer membrane lipoprotein
Tbd_1417	ENOG4105BZS	acriflavin resistance protein
Tbd_1418	ENOG4105C1P	efflux transporter, rnd family, mfp subunit
Tbd_1420	ENOG4107QMV	Part of the ABC transporter complex PstSACB involved in phosphate import (By similarity)
Tbd_1425	ENOG4108UXE	Protein tyrosine phosphatase
Tbd_1426	ENOG4105D6J	arsenicaL-resistance protein
Tbd_1428	ENOG41089UC	methyltransferase, type 11
Tbd_1432	ENOG4108VAU	general secretion pathway protein G
Tbd_1434	ENOG4107QHF	type ii secretion system protein e
Tbd_1440	ENOG4105X0D	Fimbrial protein
Tbd_1446	ENOG4105DCG	PHP domain protein
Tbd_1453	ENOG4105CPF	Cell wall formation (By similarity)
Tbd_1456	ENOG4105BZU	Histidine kinase
Tbd_1462	ENOG4105D64	Mechanosensitive ion channel
Tbd_1463	ENOG4105K9U	however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity)
Tbd_1465	ENOG4105C5T	Phosphoribosyl pyrophosphate synthase
Tbd_1469	ENOG4108W6C	Dehydrogenase
Tbd_1471	ENOG4105CMR	udp-glucose 4-epimerase
Tbd_1474	ENOG4105DZQ	phospholipase D Transphosphatidylase
Tbd_1475	ENOG4105DX1	Conversion of NADPH, generated by peripheral catabolic pathways, to NADH, which can enter the respiratory chain for energy generation (By similarity)
Tbd_1480	ENOG4105BZU	Histidine kinase
Tbd_1481	ENOG4108UN4	phage SPO1 DNA polymerase-related protein
Tbd_1482	ENOG4106PT6	cdpdiacylglycerol-serine O-phosphatidyltransferase
Tbd_1483	ENOG4105DS7	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity)
Tbd_1495	ENOG4105CPI	Metal Dependent Phosphohydrolase
Tbd_1496	ENOG4105D1H	recombination factor protein RarA
Tbd_1497	ENOG4107Y7W	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane) (By similarity)
Tbd_1500	ENOG4105EAY	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
Tbd_1502	ENOG4107R15	K00850 6-phosphofructokinase 1 EC 2.7.1.11
Tbd_1504	ENOG4105CC8	Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity)
Tbd_1505	ENOG4105CET	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria (By similarity)
Tbd_1506	ENOG4105W49	UPF0434 protein
Tbd_1508	ENOG4105CHD	Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) (By similarity)
Tbd_1509	ENOG4105M8F	Biopolymer transport protein exbD tolR
Tbd_1511	ENOG4105DVS	Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity)
Tbd_1512	ENOG4105DKX	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity)
Tbd_1513	ENOG4107R1Y	fructose-bisphosphate aldolase
Tbd_1517	ENOG4105DC6	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity)
Tbd_1519	ENOG4105C5C	n-acetylmuramoyl-l-alanine amidase
Tbd_1520	ENOG4105EH2	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity)
Tbd_1522	ENOG4105F03	Provides the (R)-glutamate required for cell wall biosynthesis (By similarity)
Tbd_1523	ENOG4108YZN	class I peptide chain release factor
Tbd_1525	ENOG4105C31	Tryptophanyl-tRNA synthetase
Tbd_1526	ENOG4108Z4T	Peptidase M50
Tbd_1527	ENOG4107RTD	sua5 ycio yrdc ywlc family protein
Tbd_1528	ENOG4105DB7	PHP domain protein
Tbd_1529	ENOG4107835	probably involved in intracellular septation (By similarity)
Tbd_1530	ENOG4105K9H	YciI-like protein
Tbd_1532	ENOG4107TF3	peptidylprolyl cis-trans isomerase
Tbd_1533	ENOG4105KW8	RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity)
Tbd_1536	ENOG4105CKK	Glycosyl transferase, family 2
Tbd_1537	ENOG4105K90	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
Tbd_1538	ENOG4105CFG	Acts as a chaperone (By similarity)
Tbd_1539	ENOG4105BZ5	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity)
Tbd_1540	ENOG4105F8V	Hydrolase, tatD family
Tbd_1542	ENOG4107QRG	dna polymerase iii
Tbd_1543	ENOG4108ZMD	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity)
Tbd_1544	ENOG4105HHA	aminodeoxychorismate lyase
Tbd_1545	ENOG4105YAZ	4-amino-4-deoxychorismate lyase
Tbd_1546	ENOG4105CRQ	synthase (Component I)
Tbd_1547	ENOG4105C0Q	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity)
Tbd_1548	ENOG4105VNB	Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity)
Tbd_1549	ENOG4105CHR	reductase
Tbd_1550	ENOG4105CJF	Malonyl coA-acyl carrier protein transacylase
Tbd_1551	ENOG4105CCZ	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity)
Tbd_1552	ENOG4105C6B	Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA (By similarity)
Tbd_1553	ENOG4105VGS	50s ribosomal protein l32
Tbd_1554	ENOG4105FCQ	metal-binding, possibly nucleic acid-binding protein
Tbd_1555	ENOG4105CER	acetyl-CoA carboxylase biotin carboxylase
Tbd_1556	ENOG4107QSA	Oxaloacetate decarboxylase
Tbd_1557	ENOG4108UHJ	MAF-like protein
Tbd_1558	ENOG4105CU0	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity)
Tbd_1562	ENOG4108VXP	Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity)
Tbd_1563	ENOG4105EI2	Pseudouridine synthase
Tbd_1564	ENOG4105C03	ribonuclease
Tbd_1568	ENOG4105CCW	damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity)
Tbd_1576	ENOG4107YU2	histidine triad (hIT) protein
Tbd_1577	ENOG4105CCY	NADH flavin oxidoreductase, NADH oxidase
Tbd_1578	ENOG4107SFI	Major Facilitator superfamily
Tbd_1583	ENOG4105D6C	Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity)
Tbd_1586	ENOG41074MP	UPF0103 Mediator of ErbB2-driven cell motility-containing protein
Tbd_1587	ENOG4105BZU	Histidine kinase
Tbd_1588	ENOG4105WH1	Two component transcriptional regulator luxr family
Tbd_1592	ENOG4105DTS	flagellar hook-associated
Tbd_1593	ENOG4105MQ3	flagellar protein FliS
Tbd_1596	ENOG4105VM1	flagellar
Tbd_1597	ENOG4108T7K	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Increasing levels of c-di-GMP lead to decreased motility (By similarity)
Tbd_1598	ENOG4107R88	Chemotaxis protein (CheV)
Tbd_1599	ENOG4105VQ0	flagellar hook-basal body complex protein fliE
Tbd_1600	ENOG4105C1F	The M ring may be actively involved in energy transduction (By similarity)
Tbd_1601	ENOG4105CS3	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity)
Tbd_1603	ENOG4108JIR	Flagellum-specific ATP synthase
Tbd_1607	ENOG4105D24	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity)
Tbd_1608	ENOG4105DD5	Flagellar motor switch protein
Tbd_1609	ENOG4105K0P	flagellar biosynthesis protein
Tbd_1610	ENOG4105CN7	Flagellar biosynthetic protein FliP
Tbd_1611	ENOG4105VS8	Flagellar biosynthetic protein fliq
Tbd_1612	ENOG4105D19	Role in flagellar biosynthesis (By similarity)
Tbd_1613	ENOG4108KCC	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P) (By similarity)
Tbd_1614	ENOG4108VYJ	response regulator receiver protein
Tbd_1615	ENOG4105CMP	catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity)
Tbd_1616	ENOG4108Z4W	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis (By similarity)
Tbd_1617	ENOG4105BZU	Histidine kinase
Tbd_1618	ENOG4107RHT	methyl-accepting chemotaxis sensory transducer with Pas Pac sensor
Tbd_1619	ENOG4105C8Q	Methyl-accepting chemotaxis
Tbd_1620	ENOG4105C8Q	Methyl-accepting chemotaxis
Tbd_1621	ENOG4105CGH	5'-nucleotidase
Tbd_1622	ENOG4105C8Q	Methyl-accepting chemotaxis
Tbd_1623	ENOG4108V3W	Chemotaxis protein, CheW
Tbd_1624	ENOG4105CBS	Chea signal transduction histidine kinase
Tbd_1625	ENOG4108VYJ	response regulator receiver protein
Tbd_1627	ENOG4105DTJ	flagellar hook-associated protein
Tbd_1628	ENOG4105E1Q	flagellar hook-associated protein
Tbd_1629	ENOG4108ZW7	flagellar rod assembly protein muramidase flgj
Tbd_1630	ENOG4105D92	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation (By similarity)
Tbd_1631	ENOG4107W7W	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation (By similarity)
Tbd_1632	ENOG4105CGA	flagellar basal-body rod protein FlgG
Tbd_1633	ENOG4108KPB	Flagellar basal-body rod protein FlgF
Tbd_1634	ENOG4105BZE	flagellar hook protein, FlgE
Tbd_1635	ENOG4105W00	Flagellar hook capping protein
Tbd_1636	ENOG4108ZC9	flagellar basal-body rod protein flgc
Tbd_1637	ENOG4105K88	Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity)
Tbd_1639	ENOG4105M9M	anti-sigma28 factor FlgM
Tbd_1641	ENOG4105CWG	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34 (By similarity)
Tbd_1643	ENOG4107YAQ	Catalyzes the reduction of FMN to FMNH2 which is used to reduce pyrimidine by RutA via the Rut pathway (By similarity)
Tbd_1645	ENOG41086B8	CoB-CoM heterodisulfide reductase
Tbd_1646	ENOG4105E33	succinate dehydrogenase
Tbd_1648	ENOG4105EWK	phytoene
Tbd_1652	ENOG4105F0N	pyrophosphate phospho-hydrolase
Tbd_1656	ENOG4108JA2	transcriptioN-repair coupling factor
Tbd_1660	ENOG4105BZU	Histidine kinase
Tbd_1662	ENOG4107RZZ	dna polymerase iii epsilon subunit
Tbd_1663	ENOG4108UMW	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity)
Tbd_1665	ENOG4108RW0	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity)
Tbd_1666	ENOG4105E9H	Lytic Murein transglycosylase
Tbd_1668	ENOG4108JQ6	ABC transporter
Tbd_1669	ENOG4105C2T	Binding-protein-dependent transport systems, inner membrane component
Tbd_1672	ENOG4105CSJ	Enoyl- acyl-carrier-protein reductase NADH
Tbd_1673	ENOG4105EIN	peptidylprolyl cis-trans isomerase
Tbd_1675	ENOG4105C6P	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity)
Tbd_1676	ENOG4105CHN	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity)
Tbd_1677	ENOG4105CCQ	Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity)
Tbd_1678	ENOG4105DEA	Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation
Tbd_1696	ENOG4105FE1	phytoene synthase
Tbd_1697	ENOG4105FE1	phytoene synthase
Tbd_1698	ENOG4107QXI	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs (By similarity)
Tbd_1699	ENOG4105UBK	short-chain dehydrogenase reductase
Tbd_1700	ENOG4105D9P	serine threonine protein kinase
Tbd_1703	ENOG4105X8U	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation (By similarity)
Tbd_1704	ENOG4105WKS	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity)
Tbd_1705	ENOG4105K59	histidine triad (HIT) protein
Tbd_1706	ENOG4105KPZ	phosphoribosyl-atp pyrophosphatase
Tbd_1707	ENOG4105K8F	Phosphoribosyl-amp cyclohydrolase
Tbd_1708	ENOG4105C0S	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity)
Tbd_1709	ENOG4105CJV	Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase
Tbd_1710	ENOG4108UJE	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity)
Tbd_1711	ENOG4105ECC	imidazole-glycerol-phosphate dehydratase
Tbd_1712	ENOG4105CIH	Imidazole acetol-phosphate transaminase
Tbd_1713	ENOG4105CEK	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity)
Tbd_1720	ENOG4105HA9	of methanol dehydrogenase type
Tbd_1721	ENOG4108V0P	LemA family
Tbd_1722	ENOG4108KQJ	Type 11 methyltransferase
Tbd_1723	ENOG4108UN4	phage SPO1 DNA polymerase-related protein
Tbd_1724	ENOG4105KEG	ribosomal-protein-alanine acetyltransferase
Tbd_1725	ENOG41072GX	Peptidase M22 Glycoprotease
Tbd_1726	ENOG4105DKB	L-sorbosone dehydrogenase
Tbd_1728	ENOG4108IAB	Phoh family
Tbd_1732	ENOG4106R49	Methyltransferase
Tbd_1733	ENOG4105C1J	atp-dependent rna helicase
Tbd_1734	ENOG4105C20	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity)
Tbd_1735	ENOG41081QV	Universal stress protein
Tbd_1737	ENOG4105DZ0	fad dependent oxidoreductase
Tbd_1738	ENOG4105BZ8	glutamate synthase
Tbd_1739	ENOG4105QA4	4Fe-4S Ferredoxin, iron-sulfur binding domain protein
Tbd_1740	ENOG4106WHD	Tetrathionate reductase
Tbd_1741	ENOG4105DB1	molybdopterin oxidoreductase
Tbd_1742	ENOG4105KNM	Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity)
Tbd_1743	ENOG4108ZXC	Two component transcriptional regulator, luxr family
Tbd_1744	ENOG4105BZU	Histidine kinase
Tbd_1750	ENOG4105GR3	Histidine kinase
Tbd_1751	ENOG4105CM0	Catalyzes the synthesis of GMP from XMP (By similarity)
Tbd_1752	ENOG4105CP4	Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity)
Tbd_1754	ENOG4105VDB	UPF0125 protein
Tbd_1755	ENOG4108Z1B	Cyclase dehydrase
Tbd_1756	ENOG4108UH4	Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity)
Tbd_1757	ENOG4105CR7	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA (By similarity)
Tbd_1758	ENOG4105CWR	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity)
Tbd_1759	ENOG4108EC8	DNA internalization-related competence protein ComEC
Tbd_1760	ENOG4105CQU	Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity)
Tbd_1764	ENOG4105CBM	Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 (By similarity)
Tbd_1767	ENOG4105C0A	alcohol dehydrogenase
Tbd_1770	ENOG4108EX3	reductase
Tbd_1771	ENOG4105C2R	Single-stranded-DNA-specific exonuclease (RecJ)
Tbd_1773	ENOG4108JEB	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity)
Tbd_1774	ENOG4105CMR	udp-glucose 4-epimerase
Tbd_1775	ENOG4105C30	Nad-dependent epimerase dehydratase
Tbd_1778	ENOG4108URP	Dtdp-4-dehydrorhamnose 3,5-epimerase
Tbd_1784	ENOG4107QPH	glycogen) synthase
Tbd_1793	ENOG4107YJ4	chain length determinant protein
Tbd_1794	ENOG4105D75	Capsular exopolysaccharide family
Tbd_1795	ENOG4105DAY	polysaccharide export protein
Tbd_1801	ENOG4105D3Q	Sugar transferase
Tbd_1806	ENOG4107TUY	Histidine kinase
Tbd_1807	ENOG4105C1W	two component, sigma54 specific, transcriptional regulator, Fis family
Tbd_1829	ENOG4105KB2	stringent starvation protein b
Tbd_1830	ENOG4107MKT	Stringent starvation protein a
Tbd_1831	ENOG4105EIX	cytochrome c1
Tbd_1832	ENOG4105DJ5	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity)
Tbd_1833	ENOG4108R5F	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity)
Tbd_1834	ENOG4105C0H	protease
Tbd_1836	ENOG4105EMN	RNA polymerase sigma factor
Tbd_1839	ENOG4108RBP	3'-to-5' exoribonuclease specific for small oligoribonucleotides (By similarity)
Tbd_1841	ENOG41090A4	Pterin carbinolamine dehydratase
Tbd_1842	ENOG4105E06	May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity)
Tbd_1845	ENOG4107S0N	DJ-1 family
Tbd_1846	ENOG4108VPT	UPF0234 protein
Tbd_1848	ENOG4105NBK	UPF0345 protein
Tbd_1849	ENOG4105CDH	Citrulline--aspartate ligase
Tbd_1850	ENOG4105DBV	ornithine carbamoyltransferase
Tbd_1851	ENOG4105C8Y	Acetylornithine aminotransferase
Tbd_1854	ENOG41082GY	Binds directly to 16S ribosomal RNA (By similarity)
Tbd_1855	ENOG4105CJR	Integral membrane protein (MviN
Tbd_1856	ENOG4105DTN	riboflavin biosynthesis protein ribF
Tbd_1857	ENOG4105C07	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity)
Tbd_1858	ENOG4105M02	This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity)
Tbd_1859	ENOG4108YZY	peptidylprolyl cis-trans isomerase
Tbd_1860	ENOG4105C48	Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity)
Tbd_1865	ENOG4106855	Competence protein
Tbd_1866	ENOG4105MWK	D-amino acid dehydrogenase, small subunit
Tbd_1868	ENOG4107STW	synthase
Tbd_1872	ENOG4105ESV	Glycosyl transferase, family 4
Tbd_1876	ENOG4105C7K	acetolactate synthase
Tbd_1879	ENOG4105CF4	DegT DnrJ EryC1 StrS aminotransferase
Tbd_1880	ENOG4105FAW	cDP-glucose 4,6-dehydratase
Tbd_1881	ENOG4105EJZ	Glucose-1-phosphate cytidylyltransferase
Tbd_1885	ENOG4105D49	3-dehydroquinate synthase
Tbd_1886	ENOG4105CHR	reductase
Tbd_1890	ENOG4105E21	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity)
Tbd_1891	ENOG4105CDF	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity)
Tbd_1893	ENOG4105E3A	(ABC) transporter
Tbd_1894	ENOG4105DA5	(ABC) transporter
Tbd_1898	ENOG4107PE3	Mammalian cell entry related domain protein
Tbd_1899	ENOG4105CY3	ABC transporter, permease
Tbd_1900	ENOG4105DHJ	ABC, transporter
Tbd_1902	ENOG4105C8N	cysteinyl-tRNA synthetase
Tbd_1907	ENOG4105C28	cystathionine
Tbd_1908	ENOG4105CBA	glutamine phosphoribosylpyrophosphate amidotransferase
Tbd_1911	ENOG4105DPM	folylpolyglutamate synthase Dihydrofolate synthase
Tbd_1912	ENOG4107QTG	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA (By similarity)
Tbd_1913	ENOG4105F6H	The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity)
Tbd_1914	ENOG4105CG0	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity)
Tbd_1915	ENOG4108ZGB	N-(5'-phosphoribosyl)anthranilate isomerase
Tbd_1916	ENOG4105DI7	Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity)
Tbd_1919	ENOG4105CM3	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity)
Tbd_1920	ENOG4105C0C	Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity)
Tbd_1921	ENOG4105MQS	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity)
Tbd_1922	ENOG4105CQI	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity)
Tbd_1923	ENOG4105D8G	Major Facilitator superfamily
Tbd_1924	ENOG4105WD1	Membrane
Tbd_1925	ENOG4107YAQ	Catalyzes the reduction of FMN to FMNH2 which is used to reduce pyrimidine by RutA via the Rut pathway (By similarity)
Tbd_1927	ENOG4105BZU	Histidine kinase
Tbd_1933	ENOG4105CGD	Nad-dependent epimerase dehydratase
Tbd_1938	ENOG4105BZU	Histidine kinase
Tbd_1941	ENOG4108V7B	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide (By similarity)
Tbd_1943	ENOG4105TMB	Formate nitrite transporter
Tbd_1945	ENOG4105BZM	domain protein
Tbd_1948	ENOG4105CJJ	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity)
Tbd_1951	ENOG4105EVD	ribosomal RNA large subunit methyltransferase N
Tbd_1953	ENOG4105BZU	Histidine kinase
Tbd_1955	ENOG4105CJE	phosphoribulokinase (EC 2.7.1.19)
Tbd_1960	ENOG4108YYC	ycei family
Tbd_1972	ENOG4105C1I	TRANSCRIPTIONAl REGULATOR GntR family
Tbd_1975	ENOG4105E05	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity)
Tbd_1976	ENOG4105BZH	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity)
Tbd_1979	ENOG4105CS1	NAD(P)H quinone oxidoreductase
Tbd_1981	ENOG41085GJ	domain protein
Tbd_1982	ENOG4107XUC	SirA family
Tbd_1984	ENOG4108IG5	Transcriptional regulator
Tbd_1985	ENOG4106UX7	integral membrane protein
Tbd_1986	ENOG4105CYQ	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity)
Tbd_1987	ENOG4106PT6	cdpdiacylglycerol-serine O-phosphatidyltransferase
Tbd_1988	ENOG41071I4	Phosphatidylserine decarboxylase proenzyme
Tbd_1989	ENOG4105C6M	Alpha-keto-beta-hydroxylacyl reductoisomerase
Tbd_1990	ENOG4108ZP8	Acetolactate synthase small subunit
Tbd_1991	ENOG4105C7K	acetolactate synthase
Tbd_1998	ENOG4105CQB	FAD linked oxidase domain protein
Tbd_1999	ENOG4105BZ5	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity)
Tbd_2006	ENOG4108YXY	alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
Tbd_2007	ENOG4105BZQ	cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase
Tbd_2008	ENOG4105CQ7	ATP-dependent helicase
Tbd_2015	ENOG4105DGN	Electron transport complex
Tbd_2016	ENOG4108R3D	Electron transport complex
Tbd_2017	ENOG4107QTR	Required for nitrogen fixation. May be part of a membrane complex functioning as an intermediate in the electron transport to nitrogenase (By similarity)
Tbd_2018	ENOG4105D6A	Electron transport complex
Tbd_2020	ENOG4105DZB	Electron transport complex
Tbd_2021	ENOG4105CSM	endonuclease III
Tbd_2023	ENOG4105BZU	Histidine kinase
Tbd_2024	ENOG4105CD5	CoA-binding domain protein
Tbd_2026	ENOG4105N7H	Cytochrome
Tbd_2027	ENOG4106RE7	Cytochrome
Tbd_2029	ENOG4105KK6	nuclease
Tbd_2031	ENOG4105F91	Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity)
Tbd_2032	ENOG4105CI8	Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons (By similarity)
Tbd_2033	ENOG4105CFX	Catalyzes the ferrous insertion into protoporphyrin IX (By similarity)
Tbd_2035	ENOG4107S7U	Sulfide dehydrogenase
Tbd_2036	ENOG41081QV	Universal stress protein
Tbd_2040	ENOG4105C0V	Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity)
Tbd_2042	ENOG4105DWA	May conjugate Arg from its aminoacyl-tRNA to the N- termini of proteins containing an N-terminal aspartate or glutamate
Tbd_2043	ENOG4108R4Z	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine (By similarity)
Tbd_2044	ENOG4105C59	p-type ATPase
Tbd_2048	ENOG4105EHG	Permease protein
Tbd_2049	ENOG4108IPX	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system (By similarity)
Tbd_2050	ENOG4105DJ0	Poly(A) Polymerase
Tbd_2051	ENOG4105K8U	2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
Tbd_2053	ENOG4105CCG	Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity)
Tbd_2054	ENOG4107R03	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity)
Tbd_2055	ENOG4108Z2X	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine (By similarity)
Tbd_2057	ENOG4105CXW	Synthesizes alpha-1,4-glucan chains using ADP-glucose (By similarity)
Tbd_2058	ENOG4105C9C	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity)
Tbd_2059	ENOG4107SBB	4-alpha-glucanotransferase (EC 2.4.1.25)
Tbd_2061	ENOG4107QQ4	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity)
Tbd_2062	ENOG4105CHC	glucokinase (EC 2.7.1.2)
Tbd_2063	ENOG4107QP8	phosphohexose isomerase
Tbd_2064	ENOG4108IAJ	Nad-dependent epimerase dehydratase
Tbd_2065	ENOG4105DFH	Transport of potassium into the cell (By similarity)
Tbd_2068	ENOG4105CDU	Replicative dna helicase
Tbd_2069	ENOG4105CAR	Terminase, large subunit
Tbd_2074	ENOG4105E2N	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity)
Tbd_2075	ENOG4105C6U	Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity)
Tbd_2077	ENOG4108K0D	peptidase, M48
Tbd_2078	ENOG4105VIE	preprotein translocase, subunit YajC
Tbd_2079	ENOG4107QN8	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity)
Tbd_2080	ENOG4107RAB	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity)
Tbd_2081	ENOG4107T5V	SNARE associated Golgi
Tbd_2083	ENOG4105CSZ	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate (By similarity)
Tbd_2084	ENOG41071DT	Involved in DNA repair and RecF pathway recombination (By similarity)
Tbd_2085	ENOG4105CWT	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity)
Tbd_2086	ENOG4108ZBM	Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity)
Tbd_2088	ENOG4105C3F	Signal peptidase i
Tbd_2089	ENOG4105C4S	Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity)
Tbd_2091	ENOG4105C0H	protease
Tbd_2095	ENOG4105EMN	RNA polymerase sigma factor
Tbd_2096	ENOG4108IYU	L-aspartate oxidase
Tbd_2098	ENOG4106XY2	Folate-binding protein involved in regulating the level of ATP-DnaA and in the modification of some tRNAs. It is probably a key factor in regulatory networks that act via tRNA modification, such as initiation of chromosomal replication (By similarity)
Tbd_2100	ENOG4105CJ4	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity)
Tbd_2101	ENOG4105CDU	Replicative dna helicase
Tbd_2102	ENOG4105K9Q	Binds to the 23S rRNA (By similarity)
Tbd_2103	ENOG4105VH8	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity)
Tbd_2105	ENOG4108ZDX	Binds together with S18 to 16S ribosomal RNA (By similarity)
Tbd_2106	ENOG4105CXN	decarboxylase
Tbd_2107	ENOG4105DHP	deoxycytidine triphosphate deaminase
Tbd_2110	ENOG4105EJF	Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity)
Tbd_2111	ENOG4105I7M	spermidine synthase
Tbd_2112	ENOG4105C90	Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity)
Tbd_2113	ENOG4105E4C	Lytic transglycosylase catalytic
Tbd_2119	ENOG4108IJ0	Aspartate ammonia-lyase
Tbd_2120	ENOG4105C9W	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity)
Tbd_2121	ENOG4108Q79	6-phosphogluconolactonase (EC 3.1.1.31)
Tbd_2123	ENOG4108J5G	6-phosphogluconate dehydrogenase
Tbd_2124	ENOG4105EZI	multiple antibiotic resistance (MarC)-related protein
Tbd_2125	ENOG4105CZ1	Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity)
Tbd_2126	ENOG4105CA8	Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity)
Tbd_2127	ENOG4105CA8	Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity)
Tbd_2130	ENOG4105CEN	a g-specific adenine glycosylase
Tbd_2134	ENOG4105CM2	brancheD-chain amino acid aminotransferase
Tbd_2137	ENOG4105DNZ	Alpha Beta Hydrolase
Tbd_2139	ENOG4107TYR	Glycosyl Transferase
Tbd_2140	ENOG4105D7N	magnesium and cobalt transport protein CorA
Tbd_2143	ENOG4108RIR	Molybdenum cofactor biosynthesis protein
Tbd_2147	ENOG4105N42	UPF0307 protein
Tbd_2148	ENOG4105CMS	peptidase U62, modulator of DNA gyrase
Tbd_2151	ENOG4105CG6	trap dicarboxylate transporter dctm subunit
Tbd_2153	ENOG4105CCT	upf0313 protein
Tbd_2157	ENOG4107TJ9	Cytochrome
Tbd_2159	ENOG4105D58	Diguanylate phosphodiesterase
Tbd_2163	ENOG4108S0N	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol (By similarity)
Tbd_2164	ENOG4105CH5	extracellular solute-binding protein, family 7
Tbd_2165	ENOG4105C65	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity)
Tbd_2166	ENOG4108Z11	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity)
Tbd_2167	ENOG4108UHE	carbonic anhydrase
Tbd_2168	ENOG4105D1W	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity)
Tbd_2171	ENOG4105CJD	(Anaerobic) ribonucleoside-triphosphate reductase
Tbd_2174	ENOG4105FQT	
Tbd_2183	ENOG4105XPQ	lipid carrier protein
Tbd_2185	ENOG4106RZ4	Peptidase U32
Tbd_2186	ENOG4105CFP	Peptidase U32
Tbd_2187	ENOG4105N5T	Radical SAM Protein
Tbd_2188	ENOG4105EA8	2-Nitropropane dioxygenase
Tbd_2190	ENOG4105C66	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity)
Tbd_2191	ENOG4108UTT	Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity)
Tbd_2192	ENOG4107YIM	Involved in the transcription termination process (By similarity)
Tbd_2193	ENOG4105CG2	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity)
Tbd_2194	ENOG4108ZAI	phosphatidylglycerophosphatase a
Tbd_2197	ENOG4105C68	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity)
Tbd_2198	ENOG4108004	Modulates RecA activity (By similarity)
Tbd_2201	ENOG4105CUC	YeeE YedE family protein
Tbd_2202	ENOG4105FD2	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity)
Tbd_2203	ENOG4107VRB	Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity)
Tbd_2204	ENOG4105UFD	tol-pal system protein YbgF
Tbd_2205	ENOG4105KCK	Peptidoglycan-associated lipoprotein
Tbd_2206	ENOG4107R6Y	Involved in the TonB-independent uptake of proteins (By similarity)
Tbd_2208	ENOG4105M8F	Biopolymer transport protein exbD tolR
Tbd_2209	ENOG4105E02	MotA TolQ exbB proton channel
Tbd_2210	ENOG4107YD3	Thioesterase
Tbd_2211	ENOG4105CKJ	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity)
Tbd_2212	ENOG4105BZU	Histidine kinase
Tbd_2213	ENOG4105KA4	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity)
Tbd_2214	ENOG4105NHU	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group (By similarity)
Tbd_2215	ENOG4105CDY	transcriptional regulatory protein
Tbd_2216	ENOG4105DKQ	ROK family
Tbd_2218	ENOG4107S78	Band 7 protein
Tbd_2219	ENOG4105PV3	Inner membrane protein yqiJ
Tbd_2220	ENOG4105CEP	NADH dehydrogenase
Tbd_2221	ENOG4105D7A	ATP-binding protein
Tbd_2222	ENOG4105DK0	Indole-3-glycerol phosphate synthase
Tbd_2223	ENOG4107QYG	anthranilate phosphoribosyltransferase
Tbd_2224	ENOG4105DDQ	anthranilate synthase
Tbd_2225	ENOG4107SA8	fad-dependent pyridine nucleotide-disulfide oxidoreductase
Tbd_2227	ENOG4105C1W	two component, sigma54 specific, transcriptional regulator, Fis family
Tbd_2229	ENOG4108VXP	Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity)
Tbd_2231	ENOG4105NWN	ApaG protein
Tbd_2232	ENOG4105CA3	membrane-bound lytic murein transglycosylase
Tbd_2235	ENOG4105BZU	Histidine kinase
Tbd_2236	ENOG4108NEV	two component transcriptional regulator, LytTR family
Tbd_2237	ENOG4105WH1	Two component transcriptional regulator luxr family
Tbd_2239	ENOG4107FSV	UPF0391 membrane protein
Tbd_2243	ENOG4105CQX	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity)
Tbd_2246	ENOG4105FDF	Could be involved in DNA repair (By similarity)
Tbd_2247	ENOG4105DQE	DNA ligase
Tbd_2250	ENOG4105VDW	Csbd family
Tbd_2253	ENOG4105DSF	transport protein
Tbd_2254	ENOG41066T0	asmA family
Tbd_2256	ENOG4105CK4	Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity)
Tbd_2266	ENOG4105C59	p-type ATPase
Tbd_2274	ENOG4105D7T	ABC transporter
Tbd_2276	ENOG4107QMH	DNA methylase
Tbd_2279	ENOG4105BZU	Histidine kinase
Tbd_2280	ENOG4108YZY	peptidylprolyl cis-trans isomerase
Tbd_2285	ENOG4105DZ2	Transcriptional regulator
Tbd_2286	ENOG4105DSS	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity)
Tbd_2288	ENOG4107SA6	carbon-phosphorus lyase complex accessory protein
Tbd_2289	ENOG4105MFQ	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP) (By similarity)
Tbd_2290	ENOG4105FD8	phosphonate metabolism protein PhnM
Tbd_2291	ENOG4105HRV	phosphonate c-p lyase system protein phnl
Tbd_2292	ENOG4105ENV	phosphonate C-P lyase system protein PhnK
Tbd_2293	ENOG4105FT8	Phosphonate metabolism
Tbd_2299	ENOG4105D5T	phosphonate abc transporter
Tbd_2301	ENOG4107RJJ	Transcriptional regulator
Tbd_2302	ENOG4105K7U	Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization (By similarity)
Tbd_2303	ENOG4107QMS	site-determining protein
Tbd_2304	ENOG4105VJP	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell (By similarity)
Tbd_2308	ENOG4105KH3	nitrite reductase (NAD(P)h) small subunit
Tbd_2309	ENOG4108IFG	nitrite reductase, (NAD(P)H)
Tbd_2312	ENOG4107Y70	Heat shock protein
Tbd_2314	ENOG4107ZIF	6-carboxy-5,6,7,8-tetrahydropterin synthase
Tbd_2315	ENOG4107QZF	nitrite reductase NADPH large subunit
Tbd_2316	ENOG4105VCQ	rubredoxin
Tbd_2317	ENOG4108RAC	Rubrerythrin
Tbd_2318	ENOG4105W39	Membrane
Tbd_2319	ENOG4105BZS	acriflavin resistance protein
Tbd_2320	ENOG4105ENT	Efflux transporter rnd family, mfp subunit
Tbd_2323	ENOG4105C5Q	Transcriptional regulator
Tbd_2327	ENOG4108Z0T	Part of a sulfur-relay system (By similarity)
Tbd_2328	ENOG4105DDW	LysR family Transcriptional regulator
Tbd_2329	ENOG4105CJJ	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity)
Tbd_2331	ENOG4105T95	Thiol disulfide interChange protein
Tbd_2332	ENOG4105EAK	ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family
Tbd_2333	ENOG4105D0A	hydroxylase
Tbd_2334	ENOG4107RAQ	aminopeptidase
Tbd_2335	ENOG4108S0S	Nucleotidyl transferase
Tbd_2336	ENOG4105EHM	Aminoglycoside phosphotransferase
Tbd_2337	ENOG4105E7H	involved in the assembly of LPS in the outer leaflet of the outer membrane. Determines N-hexane tolerance and is involved in outer membrane permeability. Essential for envelope biogenesis (By similarity)
Tbd_2338	ENOG4105DBD	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation (By similarity)
Tbd_2339	ENOG4105CEZ	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) (By similarity)
Tbd_2340	ENOG4105D1X	Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity)
Tbd_2346	ENOG4108ZI0	d,d-heptose 1,7-bisphosphate phosphatase
Tbd_2347	ENOG4105C38	Glycyl-tRNA synthetase beta subunit
Tbd_2348	ENOG4107QIB	glycyl-tRNA synthetase, alpha subunit
Tbd_2349	ENOG4105EQW	The exact function is not known. Can catalyze the reduction of a variety of substrates like dimethyl sulfoxide, trimethylamine N-oxide, phenylmethyl sulfoxide and L-methionine sulfoxide. Cannot reduce cyclic N-oxides. Shows no activity as sulfite oxidase (By similarity)
Tbd_2351	ENOG4105C5H	ABC transporter
Tbd_2353	ENOG4105E0F	Histidine kinase
Tbd_2354	ENOG4105DPZ	Two component transcriptional regulator (Winged helix family
Tbd_2358	ENOG4105DP0	ferredoxin-NADP reductase
Tbd_2360	ENOG4105D4J	Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate
Tbd_2362	ENOG4107SC1	transglycosylase
Tbd_2363	ENOG4105C7B	Threonine dehydratase
Tbd_2364	ENOG4105E66	phosphoriboisomerase A
Tbd_2365	ENOG41067SF	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase (By similarity)
Tbd_2366	ENOG4105DHA	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity (By similarity)
Tbd_2367	ENOG4108ZQD	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity)
Tbd_2370	ENOG4107QHF	type ii secretion system protein e
Tbd_2371	ENOG4108JU6	CBS domain protein
Tbd_2372	ENOG4105CRE	cytochrome C
Tbd_2373	ENOG4105CB9	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
Tbd_2374	ENOG4108ZR6	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity)
Tbd_2375	ENOG4105D6X	Specifically methylates guanosine-37 in various tRNAs (By similarity)
Tbd_2376	ENOG4108YY1	This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity)
Tbd_2377	ENOG4105K85	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity)
Tbd_2378	ENOG4105C13	Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity)
Tbd_2382	ENOG4105K7Z	Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity)
Tbd_2384	ENOG4105CPM	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity)
Tbd_2385	ENOG4105VCC	30S ribosomal protein S21
Tbd_2389	ENOG4105EC0	Required for nucleoid occlusion (NO) phenomenon, which prevents Z-ring formation and cell division over the nucleoid. Acts as a DNA-associated cell division inhibitor that binds simultaneously chromosomal DNA and FtsZ, and disrupts the assembly of FtsZ polymers. SlmA-DNA-binding sequences (SBS) are dispersed on non-Ter regions of the chromosome, preventing FtsZ polymerization at these regions (By similarity)
Tbd_2390	ENOG4105D06	uba thif-type nad fad binding protein
Tbd_2392	ENOG4105CN1	protease
Tbd_2393	ENOG41063SB	peptidase
Tbd_2394	ENOG4105CJI	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity)
Tbd_2395	ENOG41080HT	Transcriptional regulator, arsr family
Tbd_2397	ENOG4105BZS	acriflavin resistance protein
Tbd_2399	ENOG4107YZP	Rhodanese domain protein
Tbd_2402	ENOG4105IX2	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA (By similarity)
Tbd_2404	ENOG4105CSF	NADPH-dependent glycerol-3-phosphate dehydrogenase
Tbd_2406	ENOG4107RHT	methyl-accepting chemotaxis sensory transducer with Pas Pac sensor
Tbd_2407	ENOG4108UIQ	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity)
Tbd_2409	ENOG4105D7Z	glutathione synthase
Tbd_2411	ENOG41081YB	ApbE family
Tbd_2413	ENOG41080Z8	PHOSPHOCARRIER protein
Tbd_2414	ENOG4105BZ3	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity)
Tbd_2415	ENOG410890F	Dynamin family
Tbd_2416	ENOG4108VIA	integral membrane protein
Tbd_2417	ENOG4105II7	pyrroline-5-carboxylate reductase
Tbd_2418	ENOG4105DFA	alanine racemase domain protein
Tbd_2419	ENOG4105CZX	twitching motility protein
Tbd_2420	ENOG4105CZX	twitching motility protein
Tbd_2424	ENOG4105C4H	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity)
Tbd_2425	ENOG4108YXA	Membrane
Tbd_2428	ENOG4105BZU	Histidine kinase
Tbd_2430	ENOG4105C5H	ABC transporter
Tbd_2432	ENOG4108Z0R	Transferase
Tbd_2433	ENOG4105DGW	oligopeptidase A
Tbd_2437	ENOG4105C03	ribonuclease
Tbd_2438	ENOG4108Z03	MAF-like protein
Tbd_2439	ENOG4108UXA	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity)
Tbd_2440	ENOG4105KEM	Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation (By similarity)
Tbd_2441	ENOG4108Z1W	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity)
Tbd_2442	ENOG4105C2S	Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity)
Tbd_2445	ENOG4105C8T	Leucyl-tRNA synthetase
Tbd_2449	ENOG4105C4R	Atp-dependent dna helicase
Tbd_2452	ENOG4108URH	decarboxylase
Tbd_2453	ENOG4105C2M	dna polymerase I
Tbd_2455	ENOG4105M2E	Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity)
Tbd_2456	ENOG4105CEH	Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity)
Tbd_2457	ENOG4105VY0	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters (By similarity)
Tbd_2458	ENOG4105DC1	bifunctional purine biosynthesis protein purh
Tbd_2459	ENOG4105C12	Phosphoribosylglycinamide synthetase
Tbd_2460	ENOG4107XQ8	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity)
Tbd_2461	ENOG4105DBS	Key enzyme in heme biosynthesis. Catalyzes the oxidative decarboxylation of propionic acid side chains of rings A and B of coproporphyrinogen III (By similarity)
Tbd_2463	ENOG4105BZU	Histidine kinase
Tbd_2464	ENOG4105WH1	Two component transcriptional regulator luxr family
Tbd_2469	ENOG4105CKD	glutathione-regulated potassium-efflux system protein
Tbd_2471	ENOG4105CB8	Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity)
Tbd_2473	ENOG4105C0Y	Responsible for the amidation of carboxylic groups at position A and C of either cobyrinic acid or hydrogenobrynic acid. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity)
Tbd_2475	ENOG4105QA4	4Fe-4S Ferredoxin, iron-sulfur binding domain protein
Tbd_2480	ENOG4108Z0T	Part of a sulfur-relay system (By similarity)
Tbd_2481	ENOG4105YKK	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions (By similarity)
Tbd_2482	ENOG4108ZKU	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions (By similarity)
Tbd_2483	ENOG4108ZAT	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE (By similarity)
Tbd_2484	ENOG4105PJW	Sulfite reductase dissimilatory-type beta subunit
Tbd_2485	ENOG4105CY1	sulfite reductase, dissimilatory-type alpha subunit
Tbd_2489	ENOG4105KHC	sulfurtransferase
Tbd_2492	ENOG4105C7E	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity)
Tbd_2493	ENOG4105C8K	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity)
Tbd_2494	ENOG4105EQY	Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity)
Tbd_2499	ENOG4105M2J	Glutaredoxin
Tbd_2500	ENOG4105C1W	two component, sigma54 specific, transcriptional regulator, Fis family
Tbd_2501	ENOG4105CUX	Signal transduction histidine kinase
Tbd_2503	ENOG4105C5F	glutamine synthetase
Tbd_2504	ENOG4105E2X	shikimate dehydrogenase
Tbd_2505	ENOG4108VKV	Monofunctional biosynthetic peptidoglycan transglycosylase
Tbd_2506	ENOG4105CJW	magnesium transporter
Tbd_2507	ENOG4105BZ1	(ABC) transporter
Tbd_2508	ENOG4105CB3	Required for the thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32) (By similarity)
Tbd_2509	ENOG4105C5R	Aminotransferase
Tbd_2517	ENOG4105SYT	Methylenetetrahydrofolate reductase
Tbd_2519	ENOG4105C3E	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine (By similarity)
Tbd_2521	ENOG4105CPH	Catalyzes the formation of S-adenosylmethionine from methionine and ATP
Tbd_2523	ENOG4105D1S	lipid A biosynthesis
Tbd_2525	ENOG4105K4P	CoA-binding domain protein
Tbd_2526	ENOG4105E4Z	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity)
Tbd_2529	ENOG4105CSR	polyphosphate kinase 2
Tbd_2531	ENOG4105BZS	acriflavin resistance protein
Tbd_2532	ENOG4105ENT	Efflux transporter rnd family, mfp subunit
Tbd_2533	ENOG4108V7X	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
Tbd_2534	ENOG4105CKI	cobalamin synthesis protein
Tbd_2535	ENOG4105VAS	Could be involved in insertion of integral membrane proteins into the membrane (By similarity)
Tbd_2537	ENOG4108P3C	
Tbd_2539	ENOG4105FAV	ABC, transporter
Tbd_2541	ENOG4108R5P	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery (By similarity)
Tbd_2542	ENOG4105C4N	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis (By similarity)
Tbd_2543	ENOG4108TEB	UPF0114 protein
Tbd_2548	ENOG4105CBS	Chea signal transduction histidine kinase
Tbd_2549	ENOG4105C8Q	Methyl-accepting chemotaxis
Tbd_2551	ENOG4105M3Z	response regulator
Tbd_2552	ENOG4108UNF	response regulator
Tbd_2554	ENOG4105VCQ	rubredoxin
Tbd_2555	ENOG4105DWF	phosphomethylpyrimidine kinase
Tbd_2556	ENOG4108UV6	Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity)
Tbd_2557	ENOG4105CDM	Glutamate-1-semialdehyde aminotransferase
Tbd_2559	ENOG4105CSG	Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps (By similarity)
Tbd_2560	ENOG4105VF7	tolerance protein
Tbd_2563	ENOG4108EX3	reductase
Tbd_2566	ENOG4105ECF	c-methyltransferase
Tbd_2567	ENOG41076E6	Uroporphyrinogen-III Synthase
Tbd_2568	ENOG4105D6W	Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity)
Tbd_2571	ENOG4105BZU	Histidine kinase
Tbd_2572	ENOG4105DFU	Cell wall formation (By similarity)
Tbd_2574	ENOG4105IPS	esterase
Tbd_2575	ENOG4105C40	3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity)
Tbd_2577	ENOG4105CZI	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
Tbd_2578	ENOG4105BZU	Histidine kinase
Tbd_2579	ENOG4108UJU	UPF0301 protein
Tbd_2580	ENOG4107Y66	Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity)
Tbd_2581	ENOG4108UK1	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant (By similarity)
Tbd_2582	ENOG4105CXT	aspartate transcarbamylase
Tbd_2583	ENOG4105CD3	dihydroorotase
Tbd_2584	ENOG4105CE8	Transfers the fatty acyl group on membrane lipoproteins (By similarity)
Tbd_2585	ENOG4105BZU	Histidine kinase
Tbd_2586	ENOG4108Z1K	This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity)
Tbd_2587	ENOG4105CJS	Phosphopantothenoylcysteine decarboxylase
Tbd_2588	ENOG4105W5Q	DNA repair protein (RadC
Tbd_2589	ENOG4105KDC	50s ribosomal protein l28
Tbd_2590	ENOG4105W0E	50S ribosomal protein L33
Tbd_2591	ENOG4107ENK	receptor
Tbd_2593	ENOG4105DS0	Transcriptional regulator, Crp Fnr family
Tbd_2595	ENOG4105EGS	Mechanosensitive ion channel
Tbd_2596	ENOG4105CKF	membrane protein involved in aromatic hydrocarbon degradation
Tbd_2597	ENOG4108IQE	Amp-dependent synthetase and ligase
Tbd_2601	ENOG4105IPI	Membrane
Tbd_2602	ENOG4105DU1	integral membrane protein, terc
Tbd_2603	ENOG4105D0M	Protease HtpX homolog
Tbd_2604	ENOG41063Z6	transcriptional regulator, lysR family
Tbd_2606	ENOG4105K63	Thioredoxin
Tbd_2610	ENOG4105DHQ	Histidine kinase
Tbd_2611	ENOG4105ETX	regulatoR
Tbd_2614	ENOG4107YZX	Universal stress protein
Tbd_2616	ENOG4105CHH	sulfate transporter
Tbd_2620	ENOG410856B	UPF0235 protein
Tbd_2621	ENOG4105FAE	von Willebrand factor, type A
Tbd_2623	ENOG4108VFZ	ribulose bisphosphate carboxylase, small
Tbd_2624	ENOG4105DT1	RuBisCO catalyzes two reactions the carboxylation of D- ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate
Tbd_2625	ENOG4105DUM	transcriptional regulator, lysR family
Tbd_2629	ENOG4105ERU	peptidase
Tbd_2631	ENOG4105E0X	reductase
Tbd_2638	ENOG4105DT1	RuBisCO catalyzes two reactions the carboxylation of D- ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate
Tbd_2639	ENOG4105DUM	transcriptional regulator, lysR family
Tbd_2640	ENOG4105CHH	sulfate transporter
Tbd_2641	ENOG4107SKI	cobyrinic Acid a,c-diamide synthase
Tbd_2642	ENOG4105KZX	Pterin carbinolamine dehydratase
Tbd_2644	ENOG4105KNY	Microcompartments protein
Tbd_2645	ENOG4105KNY	Microcompartments protein
Tbd_2646	ENOG4105KNY	Microcompartments protein
Tbd_2651	ENOG4105DUM	transcriptional regulator, lysR family
Tbd_2653	ENOG4105EVH	UPF0753 protein
Tbd_2655	ENOG4105D65	subunit l
Tbd_2658	ENOG4108Z0T	Part of a sulfur-relay system (By similarity)
Tbd_2661	ENOG4108UM6	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity)
Tbd_2662	ENOG4105CY8	phosphoribosylaminoimidazole carboxylase atpase subunit
Tbd_2666	ENOG4108V3E	phosphoribosylglycinamide formyltransferase
Tbd_2667	ENOG4105CXB	phosphoribosylaminoimidazole synthetase
Tbd_2668	ENOG4105C8V	SAICAR synthetase
Tbd_2670	ENOG4105DW3	Response regulator receiver modulated metal dependent phosphohydrolase
Tbd_2671	ENOG4105BZU	Histidine kinase
Tbd_2672	ENOG4105E39	Enoyl-CoA hydratase
Tbd_2673	ENOG4105HF0	Membrane
Tbd_2680	ENOG4105CVR	type I restriction-modification system
Tbd_2681	ENOG4105CB5	ATP-dependent DNA helicase recG
Tbd_2683	ENOG4105C3X	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity)
Tbd_2686	ENOG4105CAS	nag kinase
Tbd_2688	ENOG4107ENK	receptor
Tbd_2692	ENOG4105DWR	Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity)
Tbd_2693	ENOG4105BZU	Histidine kinase
Tbd_2694	ENOG4105CBF	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity)
Tbd_2695	ENOG4108KE4	O-methyltransferase
Tbd_2696	ENOG41082J7	Rhodanese domain protein
Tbd_2697	ENOG4105DFG	type I secretion outer membrane protein
Tbd_2698	ENOG4105D8A	3-Deoxy-D-manno-octulosonic-acid transferase
Tbd_2701	ENOG4105CHR	reductase
Tbd_2703	ENOG4108JU5	Magnesium and cobalt efflux protein
Tbd_2704	ENOG4105KGE	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity)
Tbd_2705	ENOG4105C9A	Phoh family
Tbd_2706	ENOG4105CIW	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity)
Tbd_2707	ENOG4108UT2	hemolysin iii
Tbd_2709	ENOG4106F3G	Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5- dihydroxy-2-cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon (By similarity)
Tbd_2710	ENOG4108374	Joins Ado-cobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin) (By similarity)
Tbd_2712	ENOG4105CUP	Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB) (By similarity)
Tbd_2713	ENOG4108YZT	Adenosylcobinamide kinase
Tbd_2714	ENOG4105CAA	catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity)
Tbd_2715	ENOG4105EFT	decarboxylase
Tbd_2716	ENOG4105DH2	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group (By similarity)
Tbd_2717	ENOG4105E7Q	Cob(II)yrinic acid a,c-diamide reductase
Tbd_2718	ENOG41068B1	Cob-I-yrinic acid a,c-diamide adenosyltransferase
Tbd_2720	ENOG4105CHI	Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB (By similarity)
Tbd_2723	ENOG4105W8B	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division (By similarity)
Tbd_2724	ENOG4105MK2	5-formyltetrahydrofolate cyclo-ligase
Tbd_2725	ENOG4105BZG	amino acid carrier protein
Tbd_2726	ENOG4105W2Z	cytochrome C, class I
Tbd_2727	ENOG4105C7Z	Conserved Protein
Tbd_2729	ENOG4107QJE	Chromosome Partitioning Protein
Tbd_2730	ENOG4105C01	Dihydroxy-acid dehydratase
Tbd_2731	ENOG4105C3B	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity)
Tbd_2733	ENOG4105DXI	Major Facilitator superfamily
Tbd_2736	ENOG4105M78	Catalyzes, although with low efficiency, the sulfur transfer reaction from thiosulfate to cyanide (By similarity)
Tbd_2737	ENOG4105C57	major facilitator superfamily
Tbd_2738	ENOG4107TPS	domain protein
Tbd_2739	ENOG41080HT	Transcriptional regulator, arsr family
Tbd_2747	ENOG4108YXN	Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity)
Tbd_2752	ENOG4108HWB	Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity)
Tbd_2753	ENOG4105C0Q	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity)
Tbd_2756	ENOG4105CHR	reductase
Tbd_2758	ENOG4105DDZ	Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity)
Tbd_2764	ENOG4107VMU	Membrane
Tbd_2767	ENOG4105CBC	glutamate synthase
Tbd_2768	ENOG4105BZ8	glutamate synthase
Tbd_2769	ENOG4107WP9	Histidine kinase
Tbd_2771	ENOG4105C1W	two component, sigma54 specific, transcriptional regulator, Fis family
Tbd_2772	ENOG4107FGB	Protein of unknown function (DUF1328)
Tbd_2779	ENOG4105CFZ	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity)
Tbd_2781	ENOG4105C25	Primosomal protein n'
Tbd_2782	ENOG4105C75	arginyL-tRNA synthetase
Tbd_2786	ENOG4105WH1	Two component transcriptional regulator luxr family
Tbd_2787	ENOG4108KHN	disulfide isomerase, thiol-disulfide oxidase
Tbd_2788	ENOG4107QXG	alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
Tbd_2789	ENOG4107ZT5	Thiol disulfide interchange protein
Tbd_2790	ENOG4105CSG	Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps (By similarity)
Tbd_2791	ENOG4105XJC	Two component transcriptional regulator (Winged helix family
Tbd_2792	ENOG4105DHQ	Histidine kinase
Tbd_2793	ENOG4105C46	Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity)
Tbd_2794	ENOG4105CAJ	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity)
Tbd_2795	ENOG4105F37	PsaA and PsaB bind P700, the primary electron donor of photosystem I (PSI), as well as the electron acceptors A0, A1 and FX. PSI is a plastocyanin cytochrome c6-ferredoxin oxidoreductase, converting photonic excitation into a charge separation, which transfers an electron from the donor P700 chlorophyll pair to the spectroscopically characterized acceptors A0, A1, FX, FA and FB in turn. Oxidized P700 is reduced on the lumenal side of the thylakoid membrane by plastocyanin or cytochrome c6
Tbd_2796	ENOG4105KNM	Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity)
Tbd_2797	ENOG4105C4J	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity)
Tbd_2798	ENOG4105J80	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity)
Tbd_2799	ENOG4105CDG	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity)
Tbd_2800	ENOG4107S15	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity)
Tbd_2801	ENOG4107Z6K	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity)
Tbd_2802	ENOG4105KY6	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity)
Tbd_2803	ENOG4107RAZ	it plays a direct role in the translocation of protons across the membrane (By similarity)
Tbd_2806	ENOG4107QJE	Chromosome Partitioning Protein
Tbd_2807	ENOG4105D28	Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity)
Tbd_2808	ENOG4107RE5	NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity)
Tbd_2810	ENOG4105C5H	ABC transporter
Tbd_2811	ENOG4105E7W	lamb ycsf family protein
Tbd_2812	ENOG4107R7A	Allophanate hydrolase subunit 2
Tbd_2813	ENOG4105P4J	Allophanate hydrolase, subunit 1
Tbd_2814	ENOG4105BZU	Histidine kinase
Tbd_2815	ENOG4105C1J	atp-dependent rna helicase
Tbd_2816	ENOG4105BZ1	(ABC) transporter
Tbd_2822	ENOG410679B	prophage CP4-57 regulatory protein alpA
Tbd_2823	ENOG4105DFP	Integrase
Tbd_2824	ENOG4105C1H	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity)
Tbd_2825	ENOG4105DHW	Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins
Tbd_2826	ENOG4105NVJ	RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity)
Tbd_2827	ENOG4105VG0	50S ribosomal protein l34