locus-tag	class	description
Tbd_0001	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
Tbd_0006	COG3871	stress protein (general stress protein 26)
Tbd_0007	COG0776	regulation of translation
Tbd_0011	COG2922	Belongs to the Smg family
Tbd_0012	COG0758	DNA mediated transformation
Tbd_0014	COG0242	peptide deformylase activity
Tbd_0015	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
Tbd_0018	COG5000	phosphorelay sensor kinase activity
Tbd_0019	COG2204	response regulator
Tbd_0020	COG0569	domain protein
Tbd_0022	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
Tbd_0024	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
Tbd_0025	COG0704	Plays a role in the regulation of phosphate uptake
Tbd_0027	COG0494	nUDIX hydrolase
Tbd_0029	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
Tbd_0033	COG1074	ATP-dependent DNA helicase activity
Tbd_0035	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
Tbd_0037	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
Tbd_0038	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
Tbd_0039	COG0254	rRNA binding
Tbd_0040	COG0501	Belongs to the peptidase M48B family
Tbd_0044	COG0247	lactate metabolic process
Tbd_0046	COG0277	FAD linked oxidase domain protein
Tbd_0047	COG0277	FAD linked oxidase domain protein
Tbd_0050	COG1414	Transcriptional regulator
Tbd_0057	COG1752	Esterase of the alpha-beta hydrolase superfamily
Tbd_0059	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
Tbd_0060	COG0367	asparagine synthase
Tbd_0061	COG2951	lytic endotransglycosylase activity
Tbd_0068	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
Tbd_0069	COG0010	Belongs to the arginase family
Tbd_0081	COG2084	Dehydrogenase
Tbd_0083	COG1686	Belongs to the peptidase S11 family
Tbd_0088	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
Tbd_0089	COG2176	DNA-directed DNA polymerase activity
Tbd_0091	COG0459	protein refolding
Tbd_0092	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
Tbd_0095	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
Tbd_0097	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
Tbd_0099	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
Tbd_0101	COG2027	D-alanyl-D-alanine carboxypeptidase
Tbd_0102	COG3134	Outer membrane lipoprotein
Tbd_0103	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
Tbd_0104	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
Tbd_0105	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
Tbd_0106	COG2823	Periplasmic or secreted lipoprotein
Tbd_0107	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
Tbd_0109	COG0418	dihydroorotase activity
Tbd_0110	COG2001	Belongs to the MraZ family
Tbd_0111	COG0275	rRNA processing
Tbd_0112	COG3116	cell division
Tbd_0114	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
Tbd_0115	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
Tbd_0116	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
Tbd_0117	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
Tbd_0118	COG0772	Belongs to the SEDS family
Tbd_0119	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
Tbd_0120	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
Tbd_0121	COG0812	UDP-N-acetylmuramate dehydrogenase activity
Tbd_0122	COG1181	Belongs to the D-alanine--D-alanine ligase family
Tbd_0125	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
Tbd_0126	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
Tbd_0127	COG2885	chlorophyll binding
Tbd_0127	COG3047	cAMP biosynthetic process
Tbd_0128	COG3258	Cytochrome c
Tbd_0129	COG2863	cytochrome
Tbd_0131	COG0653	protein targeting
Tbd_0135	COG0642	Histidine kinase
Tbd_0136	COG0745	RESPONSE REGULATOR receiver
Tbd_0140	COG1368	sulfuric ester hydrolase activity
Tbd_0146	COG3245	cytochrome
Tbd_0151	COG0488	(ABC) transporter
Tbd_0152	COG5002	protein histidine kinase activity
Tbd_0152	COG5001	Diguanylate cyclase
Tbd_0154	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
Tbd_0154	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
Tbd_0155	COG1385	rRNA (uridine-N3-)-methyltransferase activity
Tbd_0159	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
Tbd_0160	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
Tbd_0161	COG0126	phosphoglycerate kinase activity
Tbd_0162	COG0469	pyruvate kinase activity
Tbd_0163	COG0191	fructose-bisphosphate aldolase activity
Tbd_0168	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
Tbd_0173	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
Tbd_0174	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
Tbd_0176	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
Tbd_0177	COG0509	glycine decarboxylation via glycine cleavage system
Tbd_0178	COG0404	The glycine cleavage system catalyzes the degradation of glycine
Tbd_0180	COG2264	protein methyltransferase activity
Tbd_0181	COG0439	Biotin carboxylase
Tbd_0182	COG0511	ligase activity, forming carbon-carbon bonds
Tbd_0183	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
Tbd_0184	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
Tbd_0185	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
Tbd_0186	COG1333	cytochrome c biogenesis protein
Tbd_0188	COG0218	Necessary for normal cell division and for the maintenance of normal septation
Tbd_0191	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
Tbd_0197	COG2204	response regulator
Tbd_0198	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
Tbd_0198	COG2205	protein histidine kinase activity
Tbd_0198	COG2198	Histidine kinase
Tbd_0198	COG0784	Response regulator, receiver
Tbd_0199	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
Tbd_0207	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
Tbd_0210	COG2046	Belongs to the sulfate adenylyltransferase family
Tbd_0210	COG0529	Catalyzes the synthesis of activated sulfate
Tbd_0213	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
Tbd_0215	COG2226	methyltransferase
Tbd_0216	COG0745	RESPONSE REGULATOR receiver
Tbd_0219	COG0277	FAD linked oxidase domain protein
Tbd_0220	COG2354	Protein conserved in bacteria
Tbd_0221	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
Tbd_0222	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
Tbd_0223	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
Tbd_0227	COG1965	Belongs to the frataxin family
Tbd_0229	COG0165	Argininosuccinate lyase
Tbd_0237	COG0606	chelatase, subunit chli
Tbd_0241	COG0004	ammonium transporteR
Tbd_0242	COG0302	gtp cyclohydrolase
Tbd_0244	COG2885	chlorophyll binding
Tbd_0246	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
Tbd_0247	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
Tbd_0248	COG1127	ABC transporter
Tbd_0253	COG2211	Major facilitator Superfamily
Tbd_0254	COG0708	Exodeoxyribonuclease III
Tbd_0255	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
Tbd_0257	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
Tbd_0258	COG0154	amidase activity
Tbd_0259	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
Tbd_0260	COG1077	Cell shape determining protein MreB Mrl
Tbd_0262	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
Tbd_0263	COG0768	penicillin binding
Tbd_0264	COG0772	Belongs to the SEDS family
Tbd_0266	COG1686	Belongs to the peptidase S11 family
Tbd_0268	COG2921	Belongs to the UPF0250 family
Tbd_0269	COG0321	lipoyl(octanoyl) transferase activity
Tbd_0270	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
Tbd_0272	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
Tbd_0274	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
Tbd_0283	COG0489	protein tyrosine kinase activity
Tbd_0285	COG3267	Type II secretory pathway component ExeA
Tbd_0285	COG3409	Peptidoglycan-binding domain 1 protein
Tbd_0291	COG0438	transferase activity, transferring glycosyl groups
Tbd_0292	COG0367	asparagine synthase
Tbd_0293	COG0438	transferase activity, transferring glycosyl groups
Tbd_0294	COG0297	glycogen (starch) synthase activity
Tbd_0301	COG1216	Glycosyl transferase, family 2
Tbd_0302	COG0438	transferase activity, transferring glycosyl groups
Tbd_0305	COG0438	transferase activity, transferring glycosyl groups
Tbd_0306	COG3119	arylsulfatase activity
Tbd_0311	COG2244	polysaccharide biosynthetic process
Tbd_0313	COG1216	Glycosyl transferase, family 2
Tbd_0315	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
Tbd_0316	COG0232	Belongs to the dGTPase family. Type 2 subfamily
Tbd_0317	COG1040	competence protein
Tbd_0319	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
Tbd_0320	COG0156	8-amino-7-oxononanoate synthase activity
Tbd_0321	COG2267	carboxylic ester hydrolase activity
Tbd_0322	COG2226	methyltransferase
Tbd_0323	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
Tbd_0326	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
Tbd_0328	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
Tbd_0334	COG1612	heme a metabolic process
Tbd_0335	COG0109	protoheme IX farnesyltransferase activity
Tbd_0337	COG1999	signal sequence binding
Tbd_0341	COG2010	Cytochrome c
Tbd_0342	COG0348	domain, Protein
Tbd_0345	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
Tbd_0348	COG0745	RESPONSE REGULATOR receiver
Tbd_0350	COG2203	Gaf domain
Tbd_0350	COG3706	GGDEF domain
Tbd_0350	COG4251	negative regulation of phosphorylation
Tbd_0350	COG5001	Diguanylate cyclase
Tbd_0356	COG0737	Belongs to the 5'-nucleotidase family
Tbd_0356	COG4085	toxin activity
Tbd_0356	COG1525	nuclease
Tbd_0357	COG0811	peptide transport
Tbd_0368	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
Tbd_0368	COG0574	Belongs to the PEP-utilizing enzyme family
Tbd_0374	COG2177	Part of the ABC transporter FtsEX involved in
Tbd_0375	COG2884	Cell division ATP-binding protein ftsE
Tbd_0377	COG0612	Peptidase, M16
Tbd_0378	COG0612	Peptidase, M16
Tbd_0379	COG0742	ribosomal rna small subunit methyltransferase
Tbd_0380	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
Tbd_0381	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
Tbd_0383	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
Tbd_0385	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
Tbd_0386	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
Tbd_0387	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
Tbd_0388	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
Tbd_0389	COG0193	aminoacyl-tRNA hydrolase activity
Tbd_0390	COG0012	GTP binding
Tbd_0391	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
Tbd_0392	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
Tbd_0394	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
Tbd_0395	COG0081	regulation of translation
Tbd_0396	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
Tbd_0397	COG0222	ribosome binding
Tbd_0398	COG0085	RNA polymerase activity
Tbd_0399	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
Tbd_0400	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
Tbd_0401	COG0049	tRNA binding
Tbd_0402	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
Tbd_0403	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
Tbd_0404	COG0051	transcription antitermination factor activity, RNA binding
Tbd_0405	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
Tbd_0406	COG0088	Forms part of the polypeptide exit tunnel
Tbd_0407	COG0089	rRNA binding
Tbd_0408	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
Tbd_0409	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
Tbd_0410	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
Tbd_0411	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
Tbd_0412	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
Tbd_0413	COG0255	Belongs to the universal ribosomal protein uL29 family
Tbd_0414	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
Tbd_0415	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
Tbd_0416	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
Tbd_0417	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
Tbd_0418	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
Tbd_0419	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
Tbd_0420	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
Tbd_0421	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
Tbd_0422	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
Tbd_0423	COG1841	ribosomal large subunit assembly
Tbd_0424	COG0200	Binds to the 23S rRNA
Tbd_0425	COG0201	protein transport
Tbd_0426	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
Tbd_0427	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
Tbd_0428	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
Tbd_0429	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
Tbd_0430	COG0202	RNA polymerase activity
Tbd_0431	COG0203	ribosomal protein L17
Tbd_0435	COG1187	pseudouridine synthase activity
Tbd_0437	COG2814	Major facilitator Superfamily
Tbd_0438	COG0629	single-stranded DNA binding
Tbd_0439	COG4206	TonB-dependent receptor
Tbd_0442	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
Tbd_0444	COG0494	nUDIX hydrolase
Tbd_0447	COG2321	neutral zinc metallopeptidase
Tbd_0451	COG1765	OsmC-like protein
Tbd_0453	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
Tbd_0454	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
Tbd_0455	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
Tbd_0456	COG0316	Belongs to the HesB IscA family
Tbd_0457	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
Tbd_0458	COG0739	heme binding
Tbd_0458	COG0741	lytic transglycosylase activity
Tbd_0458	COG1196	nuclear chromosome segregation
Tbd_0459	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
Tbd_0461	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
Tbd_0463	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
Tbd_0464	COG3161	chorismate lyase activity
Tbd_0469	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
Tbd_0471	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
Tbd_0472	COG1758	RNA polymerase activity
Tbd_0473	COG0194	GDP metabolic process
Tbd_0474	COG1561	YicC-like family, N-terminal region
Tbd_0475	COG3266	domain, Protein
Tbd_0475	COG0515	serine threonine protein kinase
Tbd_0476	COG0631	protein serine/threonine phosphatase activity
Tbd_0477	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
Tbd_0478	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
Tbd_0479	COG0635	Involved in the biosynthesis of porphyrin-containing compound
Tbd_0481	COG0302	gtp cyclohydrolase
Tbd_0484	COG2020	methyltransferase activity
Tbd_0488	COG0084	hydrolase, TatD family'
Tbd_0489	COG0670	Belongs to the BI1 family
Tbd_0490	COG0330	HflC and HflK could
Tbd_0492	COG1320	monovalent cation:proton antiporter activity
Tbd_0493	COG2212	antiporter activity
Tbd_0494	COG1863	multisubunit Na H antiporter MnhE subunit
Tbd_0495	COG0651	ATP synthesis coupled electron transport
Tbd_0496	COG1006	Multisubunit Na H antiporter MnhC subunit
Tbd_0497	COG2111	Na H antiporter
Tbd_0497	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
Tbd_0499	COG0668	transmembrane transport
Tbd_0500	COG3263	regulation of cellular component size
Tbd_0501	COG0530	calcium, potassium:sodium antiporter activity
Tbd_0502	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
Tbd_0503	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
Tbd_0504	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
Tbd_0511	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
Tbd_0512	COG0312	modulator of DNA gyrase
Tbd_0514	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
Tbd_0515	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
Tbd_0516	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
Tbd_0517	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
Tbd_0519	COG3118	belongs to the thioredoxin family
Tbd_0522	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
Tbd_0526	COG0163	prenyltransferase activity
Tbd_0529	COG1660	Displays ATPase and GTPase activities
Tbd_0530	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
Tbd_0531	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
Tbd_0533	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
Tbd_0535	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
Tbd_0537	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
Tbd_0553	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
Tbd_0558	COG0714	Associated with various cellular activities
Tbd_0561	COG3256	nitric oxide reductase
Tbd_0562	COG2010	Cytochrome c
Tbd_0564	COG3258	Cytochrome c
Tbd_0568	COG4783	chaperone-mediated protein folding
Tbd_0569	COG0315	cyclic pyranopterin monophosphate synthase activity
Tbd_0570	COG0243	molybdopterin cofactor binding
Tbd_0571	COG0437	4 iron, 4 sulfur cluster binding
Tbd_0572	COG3302	dmso reductase anchor subunit
Tbd_0573	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
Tbd_0574	COG0425	Belongs to the sulfur carrier protein TusA family
Tbd_0575	COG2210	Belongs to the sulfur carrier protein TusA family
Tbd_0577	COG0525	valine-tRNA ligase activity
Tbd_0580	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
Tbd_0583	COG2833	Protein of unknown function (DUF455)
Tbd_0585	COG2850	peptidyl-arginine hydroxylation
Tbd_0586	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
Tbd_0588	COG0825	malonyl-CoA metabolic process
Tbd_0589	COG0037	tRNA processing
Tbd_0590	COG0105	UTP biosynthetic process
Tbd_0591	COG0820	rRNA (adenine-C2-)-methyltransferase activity
Tbd_0594	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
Tbd_0595	COG0124	histidyl-tRNA synthetase
Tbd_0597	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
Tbd_0598	COG1160	GTP binding
Tbd_0602	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
Tbd_0603	COG0330	HflC and HflK could
Tbd_0604	COG0330	HflC and HflK could
Tbd_0606	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
Tbd_0607	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
Tbd_0608	COG0557	exoribonuclease II activity
Tbd_0609	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
Tbd_0612	COG1944	ATP diphosphatase activity
Tbd_0615	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
Tbd_0617	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
Tbd_0619	COG0504	CTP synthase activity
Tbd_0620	COG2877	3-deoxy-8-phosphooctulonate synthase activity
Tbd_0621	COG0148	phosphopyruvate hydratase activity
Tbd_0622	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
Tbd_0624	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
Tbd_0626	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
Tbd_0626	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
Tbd_0629	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
Tbd_0629	COG0047	phosphoribosylformylglycinamidine synthase activity
Tbd_0630	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
Tbd_0635	COG0635	Involved in the biosynthesis of porphyrin-containing compound
Tbd_0636	COG3706	GGDEF domain
Tbd_0636	COG0745	RESPONSE REGULATOR receiver
Tbd_0643	COG3278	Belongs to the heme-copper respiratory oxidase family
Tbd_0644	COG0686	Belongs to the AlaDH PNT family
Tbd_0645	COG0167	dihydroorotate dehydrogenase activity
Tbd_0646	COG1301	dicarboxylic acid transport
Tbd_0647	COG1686	Belongs to the peptidase S11 family
Tbd_0652	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
Tbd_0654	COG0022	dehydrogenase e1 component
Tbd_0654	COG0508	dehydrogenase complex catalyzes the overall conversion of
Tbd_0655	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
Tbd_0656	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
Tbd_0658	COG0564	pseudouridine synthase activity
Tbd_0660	COG0840	transmembrane signaling receptor activity
Tbd_0662	COG0028	Belongs to the TPP enzyme family
Tbd_0663	COG1285	pathogenesis
Tbd_0665	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
Tbd_0666	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
Tbd_0670	COG2197	response regulator
Tbd_0674	COG0477	Major facilitator Superfamily
Tbd_0676	COG1067	ATP-dependent peptidase activity
Tbd_0679	COG1278	Cold shock
Tbd_0680	COG4681	YaeQ
Tbd_0684	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
Tbd_0685	COG4181	ATPase activity
Tbd_0687	COG3012	SEC-C Motif Domain Protein
Tbd_0689	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
Tbd_0690	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
Tbd_0691	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
Tbd_0693	COG1185	polyribonucleotide nucleotidyltransferase activity
Tbd_0694	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
Tbd_0695	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
Tbd_0696	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
Tbd_0697	COG3064	Membrane
Tbd_0697	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
Tbd_0698	COG2251	uridine kinase activity
Tbd_0698	COG0195	Participates in both transcription termination and antitermination
Tbd_0699	COG0779	Required for maturation of 30S ribosomal subunits
Tbd_0701	COG0322	excinuclease ABC activity
Tbd_0703	COG1573	uracil-dna glycosylase
Tbd_0706	COG1730	sister chromatid segregation
Tbd_0715	COG4774	siderophore transport
Tbd_0717	COG0019	diaminopimelate decarboxylase activity
Tbd_0719	COG2814	Major facilitator Superfamily
Tbd_0722	COG4772	TonB-dependent receptor
Tbd_0723	COG0672	)-iron permease
Tbd_0727	COG1472	Belongs to the glycosyl hydrolase 3 family
Tbd_0728	COG0736	holo-[acyl-carrier-protein] synthase activity
Tbd_0730	COG2204	response regulator
Tbd_0732	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
Tbd_0734	COG1028	Short-chain dehydrogenase reductase Sdr
Tbd_0739	COG5265	(ABC) transporter
Tbd_0740	COG0438	transferase activity, transferring glycosyl groups
Tbd_0741	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
Tbd_0742	COG0859	PFAM glycosyl transferase family 9
Tbd_0749	COG3864	Putative metallopeptidase domain
Tbd_0750	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
Tbd_0752	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
Tbd_0754	COG4969	Belongs to the N-Me-Phe pilin family
Tbd_0765	COG3267	Type II secretory pathway component ExeA
Tbd_0765	COG3409	Peptidoglycan-binding domain 1 protein
Tbd_0770	COG1322	Protein conserved in bacteria
Tbd_0774	COG2346	COG2346, Truncated hemoglobins
Tbd_0775	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
Tbd_0778	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
Tbd_0780	COG0242	peptide deformylase activity
Tbd_0783	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
Tbd_0784	COG0024	Methionine aminopeptidase
Tbd_0785	COG0052	Belongs to the universal ribosomal protein uS2 family
Tbd_0786	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
Tbd_0787	COG0528	UMP kinase activity
Tbd_0788	COG0233	cytoplasmic translational termination
Tbd_0789	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
Tbd_0790	COG0575	Belongs to the CDS family
Tbd_0791	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
Tbd_0795	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
Tbd_0796	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
Tbd_0797	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
Tbd_0798	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
Tbd_0799	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
Tbd_0805	COG0045	succinate-CoA ligase (ADP-forming) activity
Tbd_0806	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
Tbd_0807	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
Tbd_0807	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
Tbd_0810	COG0564	pseudouridine synthase activity
Tbd_0813	COG0454	-acetyltransferase
Tbd_0813	COG0456	acetyltransferase
Tbd_0815	COG0542	response to heat
Tbd_0818	COG4944	Protein of unknown function (DUF1109)
Tbd_0822	COG2010	Cytochrome c
Tbd_0824	COG0714	Associated with various cellular activities
Tbd_0825	COG4548	von Willebrand factor, type A
Tbd_0827	COG0322	excinuclease ABC activity
Tbd_0828	COG0587	DNA-directed DNA polymerase activity
Tbd_0831	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
Tbd_0832	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
Tbd_0835	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
Tbd_0836	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
Tbd_0837	COG4942	peptidase
Tbd_0837	COG1388	LysM domain
Tbd_0838	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
Tbd_0839	COG1011	Hydrolase
Tbd_0842	COG0436	Aminotransferase
Tbd_0845	COG1573	uracil-dna glycosylase
Tbd_0846	COG0625	glutathione transferase activity
Tbd_0847	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
Tbd_0850	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
Tbd_0851	COG0482	sulfurtransferase activity
Tbd_0855	COG1278	Cold shock
Tbd_0857	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
Tbd_0859	COG1254	Belongs to the acylphosphatase family
Tbd_0860	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
Tbd_0860	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
Tbd_0863	COG0142	geranyltranstransferase activity
Tbd_0864	COG0261	This protein binds to 23S rRNA in the presence of protein L20
Tbd_0865	COG0211	Belongs to the bacterial ribosomal protein bL27 family
Tbd_0866	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
Tbd_0874	COG2046	Belongs to the sulfate adenylyltransferase family
Tbd_0876	COG0505	Belongs to the CarA family
Tbd_0877	COG3577	Aspartyl protease
Tbd_0878	COG1469	GTP cyclohydrolase I activity
Tbd_0879	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
Tbd_0880	COG0142	geranyltranstransferase activity
Tbd_0881	COG1722	exodeoxyribonuclease VII activity
Tbd_0891	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
Tbd_0893	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
Tbd_0896	COG0514	ATP-dependent DNA helicase (RecQ)
Tbd_0899	COG0308	aminopeptidase N
Tbd_0903	COG3852	Histidine kinase
Tbd_0906	COG2032	superoxide dismutase activity
Tbd_0921	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
Tbd_0922	COG3174	membrane
Tbd_0924	COG1028	Short-chain dehydrogenase reductase Sdr
Tbd_0933	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
Tbd_0936	COG2189	Belongs to the N(4) N(6)-methyltransferase family
Tbd_0943	COG0582	viral genome integration into host DNA
Tbd_0946	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
Tbd_0947	COG0402	S-adenosylhomocysteine deaminase activity
Tbd_0949	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
Tbd_0950	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
Tbd_0952	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
Tbd_0953	COG0287	Prephenate dehydrogenase
Tbd_0954	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
Tbd_0955	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
Tbd_0957	COG0776	regulation of translation
Tbd_0959	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
Tbd_0960	COG0284	orotidine-5'-phosphate decarboxylase activity
Tbd_0962	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
Tbd_0963	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
Tbd_0968	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
Tbd_0970	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
Tbd_0974	COG0166	Belongs to the GPI family
Tbd_0975	COG1047	Peptidyl-prolyl cis-trans
Tbd_0982	COG0501	Belongs to the peptidase M48B family
Tbd_0984	COG1234	tRNA 3'-trailer cleavage
Tbd_0987	COG3437	response regulator, receiver
Tbd_0987	COG3850	Histidine kinase
Tbd_0987	COG4999	Histidine kinase
Tbd_0987	COG2205	protein histidine kinase activity
Tbd_0992	COG0791	NLP P60 protein
Tbd_0995	COG5002	protein histidine kinase activity
Tbd_0995	COG5001	Diguanylate cyclase
Tbd_0997	COG1199	ATP-dependent helicase activity
Tbd_0999	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
Tbd_1000	COG2840	Smr protein MutS2
Tbd_1001	COG0492	ferredoxin-NADP+ reductase activity
Tbd_1002	COG1674	ftsk spoiiie
Tbd_1003	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
Tbd_1004	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
Tbd_1007	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
Tbd_1008	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
Tbd_1009	COG0291	Belongs to the bacterial ribosomal protein bL35 family
Tbd_1010	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
Tbd_1011	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
Tbd_1012	COG0072	phenylalanine-tRNA ligase activity
Tbd_1012	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
Tbd_1013	COG0776	regulation of translation
Tbd_1015	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
Tbd_1019	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
Tbd_1020	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
Tbd_1023	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
Tbd_1024	COG1763	Mo-molybdopterin cofactor biosynthetic process
Tbd_1027	COG0314	molybdopterin synthase activity
Tbd_1029	COG3038	cytochrome b561
Tbd_1032	COG2353	YceI-like domain
Tbd_1033	COG0826	peptidase U32
Tbd_1036	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
Tbd_1044	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
Tbd_1045	COG0700	Nucleoside recognition
Tbd_1046	COG0248	Ppx GppA phosphatase
Tbd_1047	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
Tbd_1051	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
Tbd_1056	COG2259	Doxx family
Tbd_1059	COG2226	methyltransferase
Tbd_1061	COG2203	Gaf domain
Tbd_1061	COG2199	diguanylate cyclase activity
Tbd_1061	COG2200	EAL domain
Tbd_1072	COG2132	Multicopper oxidase
Tbd_1076	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
Tbd_1078	COG0326	Molecular chaperone. Has ATPase activity
Tbd_1082	COG0842	Transport permease protein
Tbd_1083	COG1131	(ABC) transporter
Tbd_1087	COG2062	phosphohistidine phosphatase, SixA
Tbd_1089	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
Tbd_1091	COG1157	protein secretion by the type III secretion system
Tbd_1096	COG1987	bacterial-type flagellum assembly
Tbd_1098	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
Tbd_1099	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
Tbd_1100	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
Tbd_1101	COG0513	Belongs to the DEAD box helicase family
Tbd_1103	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
Tbd_1104	COG1017	nitric oxide dioxygenase activity
Tbd_1104	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
Tbd_1105	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
Tbd_1107	COG0247	lactate metabolic process
Tbd_1109	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
Tbd_1112	COG1741	Belongs to the pirin family
Tbd_1114	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
Tbd_1116	COG0583	DNA-binding transcription factor activity
Tbd_1117	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
Tbd_1120	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
Tbd_1121	COG0406	alpha-ribazole phosphatase activity
Tbd_1122	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
Tbd_1123	COG0735	belongs to the Fur family
Tbd_1124	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
Tbd_1125	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
Tbd_1127	COG0505	Belongs to the CarA family
Tbd_1128	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
Tbd_1129	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
Tbd_1131	COG1534	Rna-binding protein
Tbd_1132	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
Tbd_1133	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
Tbd_1134	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
Tbd_1135	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
Tbd_1136	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
Tbd_1137	COG0573	inorganic phosphate transmembrane transporter activity
Tbd_1138	COG0581	inorganic phosphate transmembrane transporter activity
Tbd_1139	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
Tbd_1140	COG0149	triose-phosphate isomerase activity
Tbd_1142	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
Tbd_1143	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
Tbd_1144	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
Tbd_1145	COG0649	NAD binding
Tbd_1146	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
Tbd_1148	COG1034	ATP synthesis coupled electron transport
Tbd_1149	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
Tbd_1150	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
Tbd_1152	COG0713	ATP synthesis coupled electron transport
Tbd_1155	COG1007	ATP synthesis coupled electron transport
Tbd_1159	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
Tbd_1164	COG1104	cysteine desulfurase activity
Tbd_1165	COG0822	iron-sulfur transferase activity
Tbd_1166	COG0316	Belongs to the HesB IscA family
Tbd_1168	COG0443	Heat shock 70 kDa protein
Tbd_1173	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
Tbd_1174	COG1640	4-alpha-glucanotransferase
Tbd_1175	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
Tbd_1181	COG0281	malic enzyme
Tbd_1183	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
Tbd_1184	COG1053	succinate dehydrogenase
Tbd_1185	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
Tbd_1186	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
Tbd_1188	COG0567	Dehydrogenase, E1 component
Tbd_1189	COG0508	dehydrogenase complex catalyzes the overall conversion of
Tbd_1190	COG1127	ABC transporter
Tbd_1192	COG0784	Response regulator, receiver
Tbd_1193	COG4191	Histidine kinase
Tbd_1195	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
Tbd_1200	COG0667	Aldo Keto reductase
Tbd_1216	COG0590	tRNA wobble adenosine to inosine editing
Tbd_1219	COG4783	chaperone-mediated protein folding
Tbd_1220	COG2171	N-acyltransferase activity
Tbd_1222	COG0697	spore germination
Tbd_1226	COG1070	Carbohydrate kinase
Tbd_1227	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
Tbd_1229	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
Tbd_1230	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
Tbd_1232	COG2766	serine protein kinase
Tbd_1233	COG2718	Belongs to the UPF0229 family
Tbd_1234	COG2719	SpoVR family
Tbd_1235	COG0723	plastoquinol--plastocyanin reductase activity
Tbd_1236	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
Tbd_1237	COG0542	response to heat
Tbd_1244	COG1360	Flagellar Motor Protein
Tbd_1245	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
Tbd_1246	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
Tbd_1249	COG1191	sigma factor activity
Tbd_1250	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
Tbd_1252	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
Tbd_1253	COG2210	Belongs to the sulfur carrier protein TusA family
Tbd_1254	COG0425	Belongs to the sulfur carrier protein TusA family
Tbd_1257	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
Tbd_1265	COG4251	negative regulation of phosphorylation
Tbd_1265	COG5001	Diguanylate cyclase
Tbd_1265	COG3706	GGDEF domain
Tbd_1265	COG2203	Gaf domain
Tbd_1266	COG4206	TonB-dependent receptor
Tbd_1268	COG2205	protein histidine kinase activity
Tbd_1268	COG0784	Response regulator, receiver
Tbd_1268	COG5002	protein histidine kinase activity
Tbd_1271	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
Tbd_1273	COG5265	(ABC) transporter
Tbd_1276	COG3380	Catalyzes the oxidation of the 1,2-dihydro- and 1,6- dihydro- isomeric forms of beta-NAD(P) back to beta-NAD(P) . May serve to protect primary metabolism dehydrogenases from inhibition by the 1,2-dihydro- and 1,6-dihydro-beta-NAD(P) isomers
Tbd_1277	COG3706	GGDEF domain
Tbd_1280	COG1104	cysteine desulfurase activity
Tbd_1281	COG1262	PFAM Formylglycine-generating sulfatase enzyme
Tbd_1282	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
Tbd_1282	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
Tbd_1285	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
Tbd_1287	COG0745	RESPONSE REGULATOR receiver
Tbd_1288	COG2205	protein histidine kinase activity
Tbd_1290	COG2197	response regulator
Tbd_1292	COG0737	Belongs to the 5'-nucleotidase family
Tbd_1295	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
Tbd_1300	COG1450	Type ii and iii secretion system protein
Tbd_1304	COG3459	Glycosyltransferase 36 associated
Tbd_1305	COG2267	carboxylic ester hydrolase activity
Tbd_1309	COG2221	Nitrite and sulphite reductase 4Fe-4S
Tbd_1311	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
Tbd_1318	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
Tbd_1324	COG2132	Multicopper oxidase
Tbd_1333	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
Tbd_1334	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
Tbd_1337	COG1742	UPF0060 membrane protein
Tbd_1339	COG2608	mercury ion transmembrane transporter activity
Tbd_1356	COG1538	Outer membrane efflux protein
Tbd_1359	COG0577	efflux transmembrane transporter activity
Tbd_1359	COG1136	(ABC) transporter
Tbd_1361	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
Tbd_1363	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
Tbd_1366	COG3300	MHYT domain
Tbd_1366	COG5001	Diguanylate cyclase
Tbd_1369	COG2221	Nitrite and sulphite reductase 4Fe-4S
Tbd_1370	COG0071	Belongs to the small heat shock protein (HSP20) family
Tbd_1375	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
Tbd_1380	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
Tbd_1381	COG0298	carbon dioxide binding
Tbd_1382	COG0375	protein maturation
Tbd_1384	COG0409	Hydrogenase expression formation protein
Tbd_1385	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
Tbd_1386	COG0309	Hydrogenase expression formation protein (HypE)
Tbd_1389	COG4263	nitrous-oxide reductase activity
Tbd_1399	COG2197	response regulator
Tbd_1400	COG3850	Histidine kinase
Tbd_1402	COG2223	nitrite transmembrane transporter activity
Tbd_1403	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
Tbd_1404	COG1140	nitrate reductase beta subunit
Tbd_1405	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
Tbd_1406	COG2181	nitrate reductase activity
Tbd_1407	COG0446	pyridine nucleotide-disulphide oxidoreductase
Tbd_1408	COG2920	part of a sulfur-relay system
Tbd_1410	COG0405	Gamma-glutamyltransferase
Tbd_1412	COG0577	efflux transmembrane transporter activity
Tbd_1412	COG1136	(ABC) transporter
Tbd_1413	COG1136	(ABC) transporter
Tbd_1413	COG0577	efflux transmembrane transporter activity
Tbd_1416	COG1538	Outer membrane efflux protein
Tbd_1417	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
Tbd_1418	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
Tbd_1420	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
Tbd_1425	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
Tbd_1426	COG0798	PFAM Bile acid sodium symporter
Tbd_1428	COG2226	methyltransferase
Tbd_1432	COG2165	general secretion pathway protein
Tbd_1446	COG1796	DNA polymerase
Tbd_1446	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
Tbd_1453	COG1181	Belongs to the D-alanine--D-alanine ligase family
Tbd_1462	COG0668	transmembrane transport
Tbd_1463	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
Tbd_1465	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
Tbd_1469	COG0300	oxidoreductase activity
Tbd_1471	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
Tbd_1474	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
Tbd_1475	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
Tbd_1481	COG1573	uracil-dna glycosylase
Tbd_1482	COG1183	phosphatidylcholine synthase activity
Tbd_1483	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
Tbd_1493	COG5654	RES domain protein
Tbd_1494	COG5642	Protein of unknown function (DUF2384)
Tbd_1496	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
Tbd_1497	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
Tbd_1500	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
Tbd_1502	COG0205	6-phosphofructokinase activity
Tbd_1504	COG0563	adenylate kinase activity
Tbd_1505	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
Tbd_1506	COG2835	tetraacyldisaccharide 4'-kinase activity
Tbd_1508	COG1663	tetraacyldisaccharide 4'-kinase activity
Tbd_1509	COG0848	biopolymer transport protein
Tbd_1510	COG0811	peptide transport
Tbd_1511	COG1570	exodeoxyribonuclease VII activity
Tbd_1512	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
Tbd_1513	COG3588	fructose-bisphosphate aldolase
Tbd_1517	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
Tbd_1519	COG0860	N-Acetylmuramoyl-L-alanine amidase
Tbd_1522	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
Tbd_1525	COG0180	Tryptophanyl-tRNA synthetase
Tbd_1526	COG1994	Peptidase M50
Tbd_1527	COG0009	L-threonylcarbamoyladenylate synthase
Tbd_1528	COG0613	PHP domain protein
Tbd_1529	COG2917	probably involved in intracellular septation
Tbd_1530	COG2350	Protein conserved in bacteria
Tbd_1531	COG0271	Belongs to the BolA IbaG family
Tbd_1532	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
Tbd_1533	COG1923	regulation of RNA biosynthetic process
Tbd_1536	COG0463	Glycosyl transferase, family 2
Tbd_1537	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
Tbd_1538	COG0443	Heat shock 70 kDa protein
Tbd_1539	COG0484	heat shock protein binding
Tbd_1540	COG0084	hydrolase, TatD family'
Tbd_1543	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
Tbd_1544	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
Tbd_1545	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
Tbd_1546	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
Tbd_1547	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
Tbd_1548	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
Tbd_1549	COG1028	Short-chain dehydrogenase reductase Sdr
Tbd_1551	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
Tbd_1552	COG0416	fatty acid biosynthetic process
Tbd_1553	COG0333	Belongs to the bacterial ribosomal protein bL32 family
Tbd_1554	COG1399	metal-binding, possibly nucleic acid-binding protein
Tbd_1555	COG0439	Biotin carboxylase
Tbd_1556	COG5016	pyruvate
Tbd_1556	COG0511	ligase activity, forming carbon-carbon bonds
Tbd_1557	COG0424	maF-like protein
Tbd_1558	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
Tbd_1562	COG0546	phosphoglycolate phosphatase activity
Tbd_1564	COG1530	ribonuclease E activity
Tbd_1565	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
Tbd_1568	COG0556	nucleotide-excision repair
Tbd_1571	COG0582	viral genome integration into host DNA
Tbd_1576	COG0537	adenosine 5'-monophosphoramidase activity
Tbd_1577	COG1902	pentaerythritol trinitrate reductase activity
Tbd_1578	COG2814	Major facilitator Superfamily
Tbd_1583	COG1136	(ABC) transporter
Tbd_1583	COG0577	efflux transmembrane transporter activity
Tbd_1586	COG1355	regulation of microtubule-based process
Tbd_1588	COG2197	response regulator
Tbd_1592	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
Tbd_1596	COG2257	FlhB HrpN YscU SpaS Family
Tbd_1597	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
Tbd_1598	COG0835	chemotaxis
Tbd_1598	COG0784	Response regulator, receiver
Tbd_1599	COG1677	Flagellar hook-basal body complex protein FliE
Tbd_1600	COG1766	The M ring may be actively involved in energy transduction
Tbd_1601	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
Tbd_1603	COG1157	protein secretion by the type III secretion system
Tbd_1608	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
Tbd_1609	COG3190	flagellar
Tbd_1611	COG1987	bacterial-type flagellum assembly
Tbd_1613	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
Tbd_1614	COG0745	RESPONSE REGULATOR receiver
Tbd_1615	COG2201	protein-glutamate methylesterase activity
Tbd_1616	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
Tbd_1617	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
Tbd_1618	COG0840	transmembrane signaling receptor activity
Tbd_1619	COG0840	transmembrane signaling receptor activity
Tbd_1620	COG0840	transmembrane signaling receptor activity
Tbd_1621	COG0737	Belongs to the 5'-nucleotidase family
Tbd_1622	COG0840	transmembrane signaling receptor activity
Tbd_1625	COG0745	RESPONSE REGULATOR receiver
Tbd_1627	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
Tbd_1628	COG1256	bacterial-type flagellum assembly
Tbd_1630	COG1706	bacterial-type flagellum-dependent cell motility
Tbd_1631	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
Tbd_1632	COG4786	Flagellar basal body rod
Tbd_1633	COG4787	bacterial-type flagellum-dependent cell motility
Tbd_1634	COG1749	Flagellar hook protein flgE
Tbd_1635	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
Tbd_1636	COG1558	bacterial-type flagellum-dependent cell motility
Tbd_1639	COG2747	anti-sigma28 factor FlgM
Tbd_1641	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
Tbd_1641	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
Tbd_1643	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
Tbd_1645	COG2048	Heterodisulfide reductase, subunit B
Tbd_1646	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
Tbd_1647	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
Tbd_1647	COG0723	plastoquinol--plastocyanin reductase activity
Tbd_1652	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
Tbd_1656	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
Tbd_1660	COG5001	Diguanylate cyclase
Tbd_1660	COG5002	protein histidine kinase activity
Tbd_1663	COG0328	RNA-DNA hybrid ribonuclease activity
Tbd_1665	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
Tbd_1666	COG0741	lytic transglycosylase activity
Tbd_1666	COG1388	LysM domain
Tbd_1668	COG4172	Belongs to the ABC transporter superfamily
Tbd_1669	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
Tbd_1670	COG0601	transmembrane transport
Tbd_1673	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
Tbd_1675	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
Tbd_1676	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
Tbd_1677	COG0740	serine-type endopeptidase activity
Tbd_1678	COG0544	peptidyl-prolyl cis-trans isomerase activity
Tbd_1686	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
Tbd_1692	COG0464	growth
Tbd_1696	COG1562	ergosterol biosynthetic process
Tbd_1698	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
Tbd_1699	COG1028	Short-chain dehydrogenase reductase Sdr
Tbd_1700	COG0515	serine threonine protein kinase
Tbd_1700	COG2815	serine threonine protein kinase
Tbd_1701	COG0004	ammonium transporteR
Tbd_1703	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
Tbd_1704	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
Tbd_1706	COG0140	phosphoribosyl-ATP diphosphatase activity
Tbd_1707	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
Tbd_1708	COG0107	imidazoleglycerol-phosphate synthase activity
Tbd_1709	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
Tbd_1710	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
Tbd_1711	COG0131	Imidazoleglycerol-phosphate dehydratase
Tbd_1712	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
Tbd_1713	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
Tbd_1717	COG0583	DNA-binding transcription factor activity
Tbd_1720	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
Tbd_1721	COG1704	LemA family
Tbd_1722	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
Tbd_1723	COG1573	uracil-dna glycosylase
Tbd_1724	COG0456	acetyltransferase
Tbd_1725	COG1214	PFAM Peptidase M22, glycoprotease
Tbd_1728	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
Tbd_1732	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
Tbd_1732	COG4797	methyltransferase
Tbd_1733	COG0513	Belongs to the DEAD box helicase family
Tbd_1734	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
Tbd_1735	COG0589	response to stress
Tbd_1737	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
Tbd_1742	COG0355	proton-transporting ATP synthase activity, rotational mechanism
Tbd_1743	COG4566	intracellular signal transduction
Tbd_1744	COG4191	Histidine kinase
Tbd_1750	COG5002	protein histidine kinase activity
Tbd_1751	COG0518	GMP synthase (glutamine-hydrolyzing) activity
Tbd_1751	COG0519	Catalyzes the synthesis of GMP from XMP
Tbd_1755	COG2867	negative regulation of translational initiation
Tbd_1756	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
Tbd_1757	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
Tbd_1758	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
Tbd_1760	COG1136	(ABC) transporter
Tbd_1762	COG0432	Pfam Uncharacterised protein family UPF0047
Tbd_1764	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
Tbd_1767	COG1454	alcohol dehydrogenase
Tbd_1770	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
Tbd_1770	COG0543	2 iron, 2 sulfur cluster binding
Tbd_1773	COG1350	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
Tbd_1774	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
Tbd_1775	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
Tbd_1783	COG1215	transferase activity, transferring glycosyl groups
Tbd_1784	COG0297	glycogen (starch) synthase activity
Tbd_1793	COG0489	protein tyrosine kinase activity
Tbd_1801	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
Tbd_1829	COG2969	positive regulation of protein catabolic process
Tbd_1830	COG0625	glutathione transferase activity
Tbd_1831	COG2857	Cytochrome c1
Tbd_1832	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
Tbd_1833	COG0723	plastoquinol--plastocyanin reductase activity
Tbd_1834	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
Tbd_1839	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
Tbd_1841	COG2154	pterin-4-alpha-carbinolamine dehydratase
Tbd_1842	COG1162	GTPase activity
Tbd_1845	COG0693	protein deglycase activity
Tbd_1846	COG1666	GTP binding
Tbd_1848	COG3123	guanosine phosphorylase activity
Tbd_1849	COG0137	argininosuccinate synthase activity
Tbd_1850	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
Tbd_1851	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
Tbd_1854	COG0268	Binds directly to 16S ribosomal RNA
Tbd_1855	COG0728	peptidoglycan biosynthetic process
Tbd_1856	COG0196	riboflavin kinase activity
Tbd_1857	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
Tbd_1858	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
Tbd_1859	COG1047	Peptidyl-prolyl cis-trans
Tbd_1860	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
Tbd_1865	COG4968	Prepilin-type N-terminal cleavage methylation domain
Tbd_1868	COG0438	transferase activity, transferring glycosyl groups
Tbd_1872	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
Tbd_1875	COG1216	Glycosyl transferase, family 2
Tbd_1875	COG1442	glycosyl transferase family 8
Tbd_1881	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
Tbd_1885	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
Tbd_1886	COG1028	Short-chain dehydrogenase reductase Sdr
Tbd_1890	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
Tbd_1891	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
Tbd_1892	COG0271	Belongs to the BolA IbaG family
Tbd_1893	COG0842	Transport permease protein
Tbd_1894	COG1131	(ABC) transporter
Tbd_1898	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
Tbd_1899	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
Tbd_1900	COG1127	ABC transporter
Tbd_1902	COG0215	cysteine-tRNA ligase activity
Tbd_1911	COG0285	dihydrofolate synthase activity
Tbd_1912	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
Tbd_1913	COG0159	tryptophan synthase activity
Tbd_1914	COG0133	tryptophan synthase activity
Tbd_1915	COG0135	phosphoribosylanthranilate isomerase activity
Tbd_1916	COG0101	tRNA pseudouridine synthase activity
Tbd_1920	COG0473	3-isopropylmalate dehydrogenase activity
Tbd_1921	COG0066	3-isopropylmalate dehydratase activity
Tbd_1922	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
Tbd_1923	COG2814	Major facilitator Superfamily
Tbd_1924	COG2832	Protein of unknown function (DUF454)
Tbd_1925	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
Tbd_1927	COG3706	GGDEF domain
Tbd_1928	COG0455	bacterial-type flagellum organization
Tbd_1933	COG0702	epimerase
Tbd_1938	COG5001	Diguanylate cyclase
Tbd_1938	COG5002	protein histidine kinase activity
Tbd_1941	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
Tbd_1943	COG2116	formate transmembrane transporter activity
Tbd_1945	COG2183	response to ionizing radiation
Tbd_1948	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
Tbd_1948	COG1017	nitric oxide dioxygenase activity
Tbd_1951	COG0820	rRNA (adenine-C2-)-methyltransferase activity
Tbd_1953	COG3706	GGDEF domain
Tbd_1955	COG3954	Phosphoribulokinase
Tbd_1960	COG2353	YceI-like domain
Tbd_1972	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
Tbd_1975	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
Tbd_1976	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
Tbd_1976	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
Tbd_1977	COG0788	formyltetrahydrofolate deformylase activity
Tbd_1981	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
Tbd_1982	COG0425	Belongs to the sulfur carrier protein TusA family
Tbd_1984	COG1309	transcriptional regulator
Tbd_1985	COG0697	spore germination
Tbd_1986	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
Tbd_1987	COG1183	phosphatidylcholine synthase activity
Tbd_1988	COG0688	phosphatidylethanolamine metabolic process
Tbd_1989	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
Tbd_1990	COG0440	acetolactate synthase activity
Tbd_1991	COG0028	Belongs to the TPP enzyme family
Tbd_1998	COG0277	FAD linked oxidase domain protein
Tbd_1999	COG0484	heat shock protein binding
Tbd_2005	COG0582	viral genome integration into host DNA
Tbd_2006	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
Tbd_2007	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
Tbd_2008	COG1643	Atp-dependent helicase
Tbd_2014	COG1959	2 iron, 2 sulfur cluster binding
Tbd_2015	COG4657	Part of a membrane complex involved in electron transport
Tbd_2016	COG2878	Part of a membrane complex involved in electron transport
Tbd_2018	COG4658	electron transport chain
Tbd_2020	COG4660	Part of a membrane complex involved in electron transport
Tbd_2021	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
Tbd_2023	COG0745	RESPONSE REGULATOR receiver
Tbd_2023	COG3706	GGDEF domain
Tbd_2024	COG0045	succinate-CoA ligase (ADP-forming) activity
Tbd_2024	COG1042	CoA-binding domain protein
Tbd_2024	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
Tbd_2025	COG0123	including yeast histone deacetylase and acetoin utilization protein
Tbd_2029	COG1525	nuclease
Tbd_2031	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
Tbd_2032	COG1420	regulation of RNA biosynthetic process
Tbd_2033	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
Tbd_2035	COG0446	pyridine nucleotide-disulphide oxidoreductase
Tbd_2036	COG0589	response to stress
Tbd_2040	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
Tbd_2042	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
Tbd_2043	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
Tbd_2044	COG2217	Heavy metal translocating P-type atpase
Tbd_2048	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
Tbd_2049	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
Tbd_2051	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
Tbd_2052	COG1428	Deoxynucleoside kinase
Tbd_2053	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
Tbd_2054	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
Tbd_2055	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
Tbd_2056	COG0058	SHG alpha-glucan phosphorylase activity
Tbd_2057	COG0297	glycogen (starch) synthase activity
Tbd_2058	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
Tbd_2061	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
Tbd_2062	COG0837	glucose binding
Tbd_2063	COG0166	Belongs to the GPI family
Tbd_2064	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
Tbd_2065	COG3158	transport of potassium into the cell
Tbd_2068	COG0305	Participates in initiation and elongation during chromosome replication
Tbd_2069	COG4626	Terminase
Tbd_2069	COG1802	Transcriptional regulator
Tbd_2073	COG0582	viral genome integration into host DNA
Tbd_2074	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
Tbd_2075	COG0343	queuine tRNA-ribosyltransferase activity
Tbd_2077	COG0501	Belongs to the peptidase M48B family
Tbd_2078	COG1862	Preprotein translocase
Tbd_2079	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
Tbd_2080	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
Tbd_2081	COG0586	Pfam SNARE associated Golgi protein
Tbd_2083	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
Tbd_2084	COG1381	Involved in DNA repair and RecF pathway recombination
Tbd_2085	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
Tbd_2086	COG0571	ribonuclease III activity
Tbd_2088	COG0681	Belongs to the peptidase S26 family
Tbd_2089	COG0481	GTPase activity
Tbd_2091	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
Tbd_2096	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
Tbd_2098	COG0354	folic acid binding
Tbd_2100	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
Tbd_2101	COG0305	Participates in initiation and elongation during chromosome replication
Tbd_2102	COG0359	binds to the 23S rRNA
Tbd_2103	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
Tbd_2105	COG0360	Binds together with S18 to 16S ribosomal RNA
Tbd_2106	COG1982	Orn Lys Arg decarboxylase major
Tbd_2107	COG0717	Belongs to the dCTP deaminase family
Tbd_2108	COG0489	protein tyrosine kinase activity
Tbd_2110	COG0494	nUDIX hydrolase
Tbd_2111	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
Tbd_2112	COG0442	prolyl-tRNA aminoacylation
Tbd_2113	COG0741	lytic transglycosylase activity
Tbd_2118	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
Tbd_2121	COG0363	glucosamine-6-phosphate deaminase activity
Tbd_2122	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
Tbd_2123	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
Tbd_2124	COG2095	MarC family integral membrane protein
Tbd_2125	COG0220	tRNA (guanine-N7-)-methyltransferase activity
Tbd_2126	COG2022	thiamine diphosphate biosynthetic process
Tbd_2130	COG1194	a g-specific adenine glycosylase
Tbd_2137	COG0429	hydrolase of the alpha beta-hydrolase fold
Tbd_2139	COG0438	transferase activity, transferring glycosyl groups
Tbd_2140	COG0598	Magnesium transport protein CorA
Tbd_2143	COG0521	Mo-molybdopterin cofactor biosynthetic process
Tbd_2147	COG3028	Belongs to the UPF0307 family
Tbd_2148	COG0312	modulator of DNA gyrase
Tbd_2151	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
Tbd_2153	COG1032	radical SAM domain protein
Tbd_2157	COG2010	Cytochrome c
Tbd_2159	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
Tbd_2163	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
Tbd_2164	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
Tbd_2165	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
Tbd_2166	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
Tbd_2167	COG3338	carbonate dehydratase activity
Tbd_2168	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
Tbd_2168	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
Tbd_2171	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
Tbd_2171	COG1328	CTP reductase activity
Tbd_2184	COG0720	synthase
Tbd_2187	COG1242	4 iron, 4 sulfur cluster binding
Tbd_2188	COG2070	2-Nitropropane dioxygenase
Tbd_2191	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
Tbd_2192	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
Tbd_2194	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
Tbd_2197	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
Tbd_2198	COG2137	regulation of response to DNA damage stimulus
Tbd_2201	COG2391	methyltransferase activity
Tbd_2202	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
Tbd_2203	COG0602	queuosine metabolic process
Tbd_2204	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
Tbd_2206	COG0823	Involved in the tonB-independent uptake of proteins
Tbd_2210	COG0824	Thioesterase
Tbd_2211	COG2255	four-way junction helicase activity
Tbd_2212	COG3706	GGDEF domain
Tbd_2212	COG0745	RESPONSE REGULATOR receiver
Tbd_2213	COG0632	four-way junction helicase activity
Tbd_2214	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
Tbd_2215	COG0217	transcriptional regulatory protein
Tbd_2216	COG1940	carbohydrate kinase activity
Tbd_2218	COG2268	Band 7 protein
Tbd_2219	COG1585	Membrane protein implicated in regulation of membrane protease activity
Tbd_2220	COG1252	NADH dehydrogenase
Tbd_2221	COG0433	COG0433 Predicted ATPase
Tbd_2222	COG0134	indole-3-glycerol-phosphate synthase activity
Tbd_2223	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
Tbd_2225	COG0446	pyridine nucleotide-disulphide oxidoreductase
Tbd_2227	COG2204	response regulator
Tbd_2229	COG0546	phosphoglycolate phosphatase activity
Tbd_2231	COG2967	ApaG domain
Tbd_2232	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
Tbd_2235	COG4585	Histidine kinase
Tbd_2236	COG3279	Response regulator of the LytR AlgR family
Tbd_2237	COG2197	response regulator
Tbd_2239	COG5487	UPF0391 membrane protein
Tbd_2243	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
Tbd_2250	COG3237	CsbD-like
Tbd_2253	COG0628	permease
Tbd_2254	COG2982	Protein involved in outer membrane biogenesis
Tbd_2256	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
Tbd_2258	COG0673	inositol 2-dehydrogenase activity
Tbd_2266	COG2217	Heavy metal translocating P-type atpase
Tbd_2267	COG0789	Transcriptional regulator
Tbd_2271	COG3707	response regulator
Tbd_2272	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
Tbd_2273	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
Tbd_2274	COG1116	anion transmembrane transporter activity
Tbd_2280	COG1047	Peptidyl-prolyl cis-trans
Tbd_2285	COG0583	DNA-binding transcription factor activity
Tbd_2286	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
Tbd_2288	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
Tbd_2289	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
Tbd_2290	COG3454	Phosphonate metabolism
Tbd_2291	COG4778	phosphonate C-P lyase system protein PhnL
Tbd_2292	COG4107	phosphonate C-P lyase system protein PhnK
Tbd_2293	COG3627	carbon phosphorus lyase activity
Tbd_2297	COG3639	organic phosphonate transmembrane transporter activity
Tbd_2299	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
Tbd_2301	COG2188	Transcriptional regulator
Tbd_2302	COG0850	regulation of cytokinetic process
Tbd_2304	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
Tbd_2308	COG2146	nitrite reductase [NAD(P)H] activity
Tbd_2309	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
Tbd_2310	COG0243	molybdopterin cofactor binding
Tbd_2311	COG0753	catalase activity
Tbd_2312	COG0071	Belongs to the small heat shock protein (HSP20) family
Tbd_2313	COG1253	flavin adenine dinucleotide binding
Tbd_2314	COG0720	synthase
Tbd_2315	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
Tbd_2316	COG1773	rubredoxin
Tbd_2317	COG1592	Rubrerythrin
Tbd_2318	COG1238	metal cluster binding
Tbd_2319	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
Tbd_2320	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
Tbd_2323	COG0583	DNA-binding transcription factor activity
Tbd_2327	COG2920	part of a sulfur-relay system
Tbd_2328	COG0583	DNA-binding transcription factor activity
Tbd_2329	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
Tbd_2329	COG1017	nitric oxide dioxygenase activity
Tbd_2331	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
Tbd_2332	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
Tbd_2333	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
Tbd_2334	COG0006	proline dipeptidase activity
Tbd_2335	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
Tbd_2337	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
Tbd_2338	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
Tbd_2339	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
Tbd_2340	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
Tbd_2341	COG3047	cAMP biosynthetic process
Tbd_2341	COG2885	chlorophyll binding
Tbd_2346	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
Tbd_2347	COG0751	glycine-tRNA ligase activity
Tbd_2348	COG0752	glycyl-tRNA synthetase alpha subunit
Tbd_2349	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
Tbd_2353	COG2205	protein histidine kinase activity
Tbd_2354	COG0745	RESPONSE REGULATOR receiver
Tbd_2360	COG0617	tRNA 3'-terminal CCA addition
Tbd_2363	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
Tbd_2364	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
Tbd_2365	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
Tbd_2366	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
Tbd_2367	COG0237	dephospho-CoA kinase activity
Tbd_2371	COG4536	flavin adenine dinucleotide binding
Tbd_2372	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
Tbd_2373	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
Tbd_2374	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
Tbd_2375	COG0336	Belongs to the RNA methyltransferase TrmD family
Tbd_2376	COG0335	large ribosomal subunit rRNA binding
Tbd_2377	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
Tbd_2382	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
Tbd_2384	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
Tbd_2385	COG0828	Belongs to the bacterial ribosomal protein bS21 family
Tbd_2388	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
Tbd_2390	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
Tbd_2392	COG0793	Belongs to the peptidase S41A family
Tbd_2393	COG4942	peptidase
Tbd_2394	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
Tbd_2395	COG0640	Transcriptional regulator
Tbd_2397	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
Tbd_2399	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
Tbd_2402	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
Tbd_2404	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
Tbd_2406	COG0840	transmembrane signaling receptor activity
Tbd_2407	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
Tbd_2409	COG0189	ligase activity
Tbd_2413	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
Tbd_2414	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
Tbd_2415	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
Tbd_2427	COG2900	Belongs to the SlyX family
Tbd_2430	COG0488	(ABC) transporter
Tbd_2432	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
Tbd_2433	COG0339	signal peptide processing
Tbd_2437	COG1530	ribonuclease E activity
Tbd_2438	COG0424	maF-like protein
Tbd_2439	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
Tbd_2440	COG0799	negative regulation of ribosome biogenesis
Tbd_2441	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
Tbd_2442	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
Tbd_2445	COG0495	leucyl-tRNA aminoacylation
Tbd_2449	COG0210	DNA helicase
Tbd_2454	COG2885	chlorophyll binding
Tbd_2454	COG3047	cAMP biosynthetic process
Tbd_2455	COG1970	mechanosensitive ion channel activity
Tbd_2457	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
Tbd_2458	COG0138	bifunctional purine biosynthesis protein purh
Tbd_2459	COG0151	Belongs to the GarS family
Tbd_2460	COG0009	L-threonylcarbamoyladenylate synthase
Tbd_2461	COG0408	coproporphyrinogen oxidase activity
Tbd_2463	COG3850	Histidine kinase
Tbd_2464	COG2197	response regulator
Tbd_2468	COG0674	pyruvate-flavodoxin oxidoreductase activity
Tbd_2468	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
Tbd_2468	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
Tbd_2468	COG1013	pyruvate-flavodoxin oxidoreductase activity
Tbd_2469	COG4651	solute:proton antiporter activity
Tbd_2469	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
Tbd_2471	COG1648	precorrin-2 dehydrogenase activity
Tbd_2471	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
Tbd_2473	COG1797	cobyrinic acid a,c-diamide synthase activity
Tbd_2480	COG2920	part of a sulfur-relay system
Tbd_2481	COG2168	tRNA wobble position uridine thiolation
Tbd_2482	COG2923	Belongs to the DsrF TusC family
Tbd_2483	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
Tbd_2484	COG2221	Nitrite and sulphite reductase 4Fe-4S
Tbd_2485	COG2221	Nitrite and sulphite reductase 4Fe-4S
Tbd_2492	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
Tbd_2493	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
Tbd_2494	COG2890	protein-(glutamine-N5) methyltransferase activity
Tbd_2499	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
Tbd_2501	COG3852	Histidine kinase
Tbd_2504	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
Tbd_2505	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
Tbd_2506	COG2239	Acts as a magnesium transporter
Tbd_2507	COG1132	(ABC) transporter
Tbd_2508	COG0037	tRNA processing
Tbd_2509	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
Tbd_2517	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
Tbd_2519	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
Tbd_2521	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
Tbd_2523	COG1560	Kdo2-lipid A biosynthetic process
Tbd_2525	COG1832	CoA-binding protein
Tbd_2526	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
Tbd_2529	COG2326	polyphosphate kinase activity
Tbd_2531	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
Tbd_2533	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
Tbd_2534	COG0523	cobalamin synthesis protein
Tbd_2535	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
Tbd_2537	COG3746	phosphate-selective porin O and P
Tbd_2539	COG1108	ABC-type Mn2 Zn2 transport systems permease components
Tbd_2541	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
Tbd_2542	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
Tbd_2555	COG0351	phosphomethylpyrimidine kinase
Tbd_2556	COG0352	thiamine-phosphate diphosphorylase activity
Tbd_2557	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
Tbd_2559	COG4232	protein-disulfide reductase activity
Tbd_2560	COG1324	tolerance protein
Tbd_2563	COG0543	2 iron, 2 sulfur cluster binding
Tbd_2563	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
Tbd_2566	COG2959	enzyme of heme biosynthesis
Tbd_2568	COG0181	hydroxymethylbilane synthase activity
Tbd_2571	COG2198	Histidine kinase
Tbd_2571	COG0784	Response regulator, receiver
Tbd_2571	COG2205	protein histidine kinase activity
Tbd_2572	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
Tbd_2574	COG3150	esterase
Tbd_2575	COG0557	exoribonuclease II activity
Tbd_2577	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
Tbd_2579	COG1678	Uncharacterized ACR, COG1678
Tbd_2580	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
Tbd_2581	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
Tbd_2582	COG0540	Belongs to the ATCase OTCase family
Tbd_2584	COG0815	Transfers the fatty acyl group on membrane lipoproteins
Tbd_2586	COG0756	dUTP diphosphatase activity
Tbd_2587	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
Tbd_2588	COG2003	Belongs to the UPF0758 family
Tbd_2589	COG0227	Belongs to the bacterial ribosomal protein bL28 family
Tbd_2590	COG0267	Belongs to the bacterial ribosomal protein bL33 family
Tbd_2591	COG4771	TonB-dependent receptor
Tbd_2593	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
Tbd_2595	COG1511	domain protein
Tbd_2595	COG3264	Mechanosensitive ion channel
Tbd_2597	COG1022	Amp-dependent synthetase and ligase
Tbd_2598	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
Tbd_2598	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
Tbd_2601	COG0628	permease
Tbd_2602	COG0861	Integral membrane protein TerC family
Tbd_2603	COG0501	Belongs to the peptidase M48B family
Tbd_2604	COG0583	DNA-binding transcription factor activity
Tbd_2606	COG3118	belongs to the thioredoxin family
Tbd_2610	COG0642	Histidine kinase
Tbd_2611	COG0745	RESPONSE REGULATOR receiver
Tbd_2613	COG0730	response to heat
Tbd_2614	COG0589	response to stress
Tbd_2616	COG0659	secondary active sulfate transmembrane transporter activity
Tbd_2620	COG1872	DUF167
Tbd_2623	COG4451	ribulose bisphosphate carboxylase, small
Tbd_2624	COG1850	ribulose-bisphosphate carboxylase activity
Tbd_2625	COG0583	DNA-binding transcription factor activity
Tbd_2626	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
Tbd_2629	COG0616	signal peptide processing
Tbd_2631	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
Tbd_2632	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
Tbd_2634	COG2203	Gaf domain
Tbd_2634	COG3706	GGDEF domain
Tbd_2634	COG5001	Diguanylate cyclase
Tbd_2634	COG4251	negative regulation of phosphorylation
Tbd_2638	COG1850	ribulose-bisphosphate carboxylase activity
Tbd_2640	COG0659	secondary active sulfate transmembrane transporter activity
Tbd_2641	COG1192	Involved in chromosome partitioning
Tbd_2642	COG2154	pterin-4-alpha-carbinolamine dehydratase
Tbd_2643	COG2193	ferroxidase activity
Tbd_2653	COG3002	Belongs to the UPF0753 family
Tbd_2655	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
Tbd_2658	COG2920	part of a sulfur-relay system
Tbd_2661	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
Tbd_2662	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
Tbd_2666	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
Tbd_2667	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
Tbd_2668	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
Tbd_2672	COG1024	Enoyl-CoA hydratase
Tbd_2673	COG0730	response to heat
Tbd_2680	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
Tbd_2683	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
Tbd_2686	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
Tbd_2688	COG4771	TonB-dependent receptor
Tbd_2690	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
Tbd_2692	COG1968	undecaprenyl-diphosphatase activity
Tbd_2693	COG3706	GGDEF domain
Tbd_2694	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
Tbd_2695	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
Tbd_2696	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
Tbd_2697	COG1538	Outer membrane efflux protein
Tbd_2703	COG4535	Mg2 and Co2 transporter CorC
Tbd_2704	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
Tbd_2705	COG1702	phosphate starvation-inducible protein PhoH
Tbd_2706	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
Tbd_2707	COG1272	protein, Hemolysin III
Tbd_2709	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
Tbd_2710	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
Tbd_2712	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
Tbd_2714	COG1492	cobalamin metabolic process
Tbd_2717	COG0778	Nitroreductase
Tbd_2720	COG4206	TonB-dependent receptor
Tbd_2724	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
Tbd_2725	COG1115	amino acid carrier protein
Tbd_2726	COG4654	Cytochrome c, class I
Tbd_2727	COG1331	Highly conserved protein containing a thioredoxin domain
Tbd_2729	COG1192	Involved in chromosome partitioning
Tbd_2730	COG0129	dihydroxy-acid dehydratase activity
Tbd_2731	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
Tbd_2733	COG2814	Major facilitator Superfamily
Tbd_2737	COG0477	Major facilitator Superfamily
Tbd_2738	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
Tbd_2738	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
Tbd_2739	COG0640	Transcriptional regulator
Tbd_2740	COG2217	Heavy metal translocating P-type atpase
Tbd_2747	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
Tbd_2752	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
Tbd_2753	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
Tbd_2756	COG1028	Short-chain dehydrogenase reductase Sdr
Tbd_2757	COG0475	glutathione-regulated potassium exporter activity
Tbd_2758	COG2226	methyltransferase
Tbd_2764	COG2323	membrane
Tbd_2767	COG0067	glutamate synthase
Tbd_2767	COG0069	glutamate synthase activity
Tbd_2767	COG0070	glutamate synthase
Tbd_2768	COG0493	'glutamate synthase
Tbd_2769	COG2205	protein histidine kinase activity
Tbd_2771	COG2204	response regulator
Tbd_2772	COG5487	UPF0391 membrane protein
Tbd_2779	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
Tbd_2781	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
Tbd_2782	COG0018	arginyl-trna synthetase
Tbd_2784	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
Tbd_2786	COG2197	response regulator
Tbd_2788	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
Tbd_2789	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
Tbd_2791	COG0745	RESPONSE REGULATOR receiver
Tbd_2793	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
Tbd_2794	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
Tbd_2795	COG2885	chlorophyll binding
Tbd_2796	COG0355	proton-transporting ATP synthase activity, rotational mechanism
Tbd_2797	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
Tbd_2798	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
Tbd_2799	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
Tbd_2800	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
Tbd_2801	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
Tbd_2803	COG0356	it plays a direct role in the translocation of protons across the membrane
Tbd_2806	COG1192	Involved in chromosome partitioning
Tbd_2807	COG0357	Ribosomal RNA small subunit methyltransferase G
Tbd_2808	COG0445	tRNA wobble uridine modification
Tbd_2811	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
Tbd_2812	COG1984	allophanate hydrolase subunit 2
Tbd_2813	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
Tbd_2814	COG3706	GGDEF domain
Tbd_2815	COG0513	Belongs to the DEAD box helicase family
Tbd_2816	COG1132	(ABC) transporter
Tbd_2822	COG3311	Transcriptional regulator
Tbd_2823	COG0582	viral genome integration into host DNA
Tbd_2824	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
Tbd_2825	COG0706	membrane insertase activity
Tbd_2826	COG0594	ribonuclease P activity
Tbd_2827	COG0230	Belongs to the bacterial ribosomal protein bL34 family