locus-tag	class	description
HZY77_00065	COG0489	protein tyrosine kinase activity
HZY77_00090	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HZY77_00100	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HZY77_00125	COG0297	glycogen (starch) synthase activity
HZY77_00165	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HZY77_00180	COG0705	Rhomboid family
HZY77_00215	COG1454	alcohol dehydrogenase
HZY77_00255	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HZY77_00285	COG0489	protein tyrosine kinase activity
HZY77_00285	COG3206	protein involved in exopolysaccharide biosynthesis
HZY77_00290	COG0489	protein tyrosine kinase activity
HZY77_00290	COG3206	protein involved in exopolysaccharide biosynthesis
HZY77_00305	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
HZY77_00315	COG2244	polysaccharide biosynthetic process
HZY77_00325	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
HZY77_00335	COG1136	(ABC) transporter
HZY77_00345	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HZY77_00355	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
HZY77_00365	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
HZY77_00395	COG0519	Catalyzes the synthesis of GMP from XMP
HZY77_00395	COG0518	GMP synthase (glutamine-hydrolyzing) activity
HZY77_00400	COG0582	viral genome integration into host DNA
HZY77_00435	COG4633	Protein conserved in bacteria
HZY77_00470	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HZY77_00510	COG0640	Transcriptional regulator
HZY77_00515	COG1968	undecaprenyl-diphosphatase activity
HZY77_00520	COG5002	protein histidine kinase activity
HZY77_00555	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HZY77_00585	COG3245	cytochrome
HZY77_00625	COG2217	Heavy metal translocating P-type atpase
HZY77_00640	COG2948	multi-organism process
HZY77_00670	COG3451	type IV secretory pathway VirB4
HZY77_00685	COG4962	Type ii secretion system protein e
HZY77_00705	COG0583	DNA-binding transcription factor activity
HZY77_00710	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HZY77_00815	COG5489	Protein of unknown function (DUF736)
HZY77_00825	COG2003	Belongs to the UPF0758 family
HZY77_00880	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
HZY77_00905	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
HZY77_00920	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HZY77_00930	COG0798	PFAM Bile acid sodium symporter
HZY77_00945	COG5001	Diguanylate cyclase
HZY77_00945	COG5002	protein histidine kinase activity
HZY77_01000	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HZY77_01035	COG2189	Belongs to the N(4) N(6)-methyltransferase family
HZY77_01040	COG1196	nuclear chromosome segregation
HZY77_01080	COG0582	viral genome integration into host DNA
HZY77_01085	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HZY77_01095	COG0513	Belongs to the DEAD box helicase family
HZY77_01100	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
HZY77_01100	COG4797	methyltransferase
HZY77_01115	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
HZY77_01125	COG1214	PFAM Peptidase M22, glycoprotease
HZY77_01130	COG0456	acetyltransferase
HZY77_01135	COG1573	uracil-dna glycosylase
HZY77_01140	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HZY77_01145	COG1704	LemA family
HZY77_01170	COG0477	Major facilitator Superfamily
HZY77_01175	COG0583	DNA-binding transcription factor activity
HZY77_01200	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HZY77_01205	COG0131	Imidazoleglycerol-phosphate dehydratase
HZY77_01210	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
HZY77_01220	COG0107	imidazoleglycerol-phosphate synthase activity
HZY77_01225	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
HZY77_01235	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HZY77_01240	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HZY77_01250	COG0004	ammonium transporteR
HZY77_01255	COG0515	serine threonine protein kinase
HZY77_01255	COG2815	serine threonine protein kinase
HZY77_01270	COG1562	ergosterol biosynthetic process
HZY77_01290	COG0740	serine-type endopeptidase activity
HZY77_01295	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
HZY77_01300	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
HZY77_01320	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HZY77_01335	COG0601	transmembrane transport
HZY77_01350	COG1388	LysM domain
HZY77_01350	COG0741	lytic transglycosylase activity
HZY77_01355	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HZY77_01360	COG2226	methyltransferase
HZY77_01380	COG5001	Diguanylate cyclase
HZY77_01380	COG5002	protein histidine kinase activity
HZY77_01395	COG0560	Phosphoserine phosphatase
HZY77_01400	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
HZY77_01405	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
HZY77_01435	COG0582	viral genome integration into host DNA
HZY77_01465	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
HZY77_01555	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HZY77_01575	COG0166	Belongs to the GPI family
HZY77_01625	COG1234	tRNA 3'-trailer cleavage
HZY77_01645	COG3842	ATPase activity
HZY77_01650	COG1175	transmembrane transport
HZY77_01660	COG0791	NLP P60 protein
HZY77_01685	COG1199	ATP-dependent helicase activity
HZY77_01700	COG0492	ferredoxin-NADP+ reductase activity
HZY77_01705	COG1674	ftsk spoiiie
HZY77_01710	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
HZY77_01715	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
HZY77_01780	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HZY77_01785	COG1459	type II secretion system
HZY77_01800	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
HZY77_01805	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
HZY77_01810	COG0291	Belongs to the bacterial ribosomal protein bL35 family
HZY77_01815	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
HZY77_01820	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
HZY77_01825	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HZY77_01825	COG0072	phenylalanine-tRNA ligase activity
HZY77_01830	COG0776	regulation of translation
HZY77_01845	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
HZY77_01860	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
HZY77_01865	COG2807	transmembrane transport
HZY77_01875	COG1262	PFAM Formylglycine-generating sulfatase enzyme
HZY77_01880	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
HZY77_01890	COG0303	'Molybdopterin
HZY77_01900	COG0314	molybdopterin synthase activity
HZY77_01915	COG0826	peptidase U32
HZY77_01930	COG4191	Histidine kinase
HZY77_01935	COG2204	response regulator
HZY77_01955	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
HZY77_01990	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
HZY77_02000	COG0248	Ppx GppA phosphatase
HZY77_02010	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
HZY77_02025	COG0583	DNA-binding transcription factor activity
HZY77_02035	COG3300	MHYT domain
HZY77_02035	COG5001	Diguanylate cyclase
HZY77_02080	COG2226	methyltransferase
HZY77_02125	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
HZY77_02135	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HZY77_02140	COG3657	addiction module killer protein
HZY77_02145	COG0326	Molecular chaperone. Has ATPase activity
HZY77_02160	COG3025	triphosphatase activity
HZY77_02185	COG1157	protein secretion by the type III secretion system
HZY77_02205	COG1338	Plays a role in the flagellum-specific transport system
HZY77_02210	COG1987	bacterial-type flagellum assembly
HZY77_02225	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HZY77_02230	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
HZY77_02235	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
HZY77_02255	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HZY77_02255	COG1017	nitric oxide dioxygenase activity
HZY77_02260	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HZY77_02270	COG0247	lactate metabolic process
HZY77_02280	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
HZY77_02285	COG1741	Belongs to the pirin family
HZY77_02300	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
HZY77_02315	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
HZY77_02325	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HZY77_02330	COG0735	belongs to the Fur family
HZY77_02335	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HZY77_02340	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
HZY77_02350	COG0505	Belongs to the CarA family
HZY77_02355	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
HZY77_02360	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HZY77_02370	COG1534	Rna-binding protein
HZY77_02385	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HZY77_02390	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
HZY77_02395	COG0573	inorganic phosphate transmembrane transporter activity
HZY77_02400	COG0581	inorganic phosphate transmembrane transporter activity
HZY77_02405	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HZY77_02410	COG0149	triose-phosphate isomerase activity
HZY77_02435	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HZY77_02440	COG0649	NAD binding
HZY77_02445	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
HZY77_02455	COG1034	ATP synthesis coupled electron transport
HZY77_02460	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
HZY77_02465	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HZY77_02475	COG0713	ATP synthesis coupled electron transport
HZY77_02490	COG1007	ATP synthesis coupled electron transport
HZY77_02505	COG2226	methyltransferase
HZY77_02515	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
HZY77_02520	COG0582	viral genome integration into host DNA
HZY77_02570	COG3451	type IV secretory pathway VirB4
HZY77_02585	COG4962	Type ii secretion system protein e
HZY77_02605	COG1335	isochorismatase
HZY77_02610	COG2204	response regulator
HZY77_02615	COG3047	cAMP biosynthetic process
HZY77_02630	COG0583	DNA-binding transcription factor activity
HZY77_02635	COG2204	response regulator
HZY77_02675	COG1192	Involved in chromosome partitioning
HZY77_02750	COG2003	Belongs to the UPF0758 family
HZY77_02825	COG4452	Inner membrane protein CreD
HZY77_02830	COG2205	protein histidine kinase activity
HZY77_02835	COG0745	RESPONSE REGULATOR receiver
HZY77_02860	COG1959	2 iron, 2 sulfur cluster binding
HZY77_02865	COG1104	cysteine desulfurase activity
HZY77_02870	COG0822	iron-sulfur transferase activity
HZY77_02875	COG0316	Belongs to the HesB IscA family
HZY77_02885	COG0443	Heat shock 70 kDa protein
HZY77_02935	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
HZY77_02955	COG0281	malic enzyme
HZY77_02960	COG2009	succinate dehydrogenase
HZY77_02970	COG1053	succinate dehydrogenase
HZY77_02980	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
HZY77_02990	COG0567	Dehydrogenase, E1 component
HZY77_03000	COG1127	ABC transporter
HZY77_03030	COG4251	negative regulation of phosphorylation
HZY77_03040	COG1289	transmembrane transporter activity
HZY77_03045	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
HZY77_03065	COG3300	MHYT domain
HZY77_03065	COG5001	Diguanylate cyclase
HZY77_03150	COG0542	response to heat
HZY77_03200	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
HZY77_03210	COG0489	protein tyrosine kinase activity
HZY77_03220	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
HZY77_03230	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
HZY77_03240	COG2210	Belongs to the sulfur carrier protein TusA family
HZY77_03245	COG0425	Belongs to the sulfur carrier protein TusA family
HZY77_03295	COG1941	NADH ubiquinone oxidoreductase 20 kDa subunit
HZY77_03305	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
HZY77_03320	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HZY77_03330	COG5265	(ABC) transporter
HZY77_03345	COG3380	Catalyzes the oxidation of the 1,2-dihydro- and 1,6- dihydro- isomeric forms of beta-NAD(P) back to beta-NAD(P) . May serve to protect primary metabolism dehydrogenases from inhibition by the 1,2-dihydro- and 1,6-dihydro-beta-NAD(P) isomers
HZY77_03360	COG3706	GGDEF domain
HZY77_03410	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
HZY77_03415	COG3795	YCII-related domain
HZY77_03425	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
HZY77_03485	COG2827	Endonuclease containing a URI domain
HZY77_03495	COG4783	chaperone-mediated protein folding
HZY77_03500	COG2171	N-acyltransferase activity
HZY77_03510	COG0697	spore germination
HZY77_03520	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HZY77_03530	COG1070	Carbohydrate kinase
HZY77_03535	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
HZY77_03545	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
HZY77_03550	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
HZY77_03560	COG2719	SpoVR family
HZY77_03570	COG2766	serine protein kinase
HZY77_03580	COG2326	polyphosphate kinase activity
HZY77_03590	COG1376	ErfK ybiS ycfS ynhG family protein
HZY77_03605	COG2814	Major facilitator Superfamily
HZY77_03615	COG1538	Outer membrane efflux protein
HZY77_03620	COG1846	Transcriptional regulator
HZY77_03625	COG2221	Nitrite and sulphite reductase 4Fe-4S
HZY77_03655	COG3284	Transcriptional regulator
HZY77_03660	COG1999	signal sequence binding
HZY77_03690	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
HZY77_03695	COG3383	formate dehydrogenase (NAD+) activity
HZY77_03720	COG1858	cytochrome C peroxidase
HZY77_03745	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HZY77_03755	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HZY77_03765	COG4566	intracellular signal transduction
HZY77_03770	COG4191	Histidine kinase
HZY77_03860	COG0010	Belongs to the arginase family
HZY77_03905	COG4191	Histidine kinase
HZY77_03970	COG0588	phosphoglycerate mutase activity
HZY77_03985	COG1229	Formylmethanofuran dehydrogenase subunit A
HZY77_04000	COG0702	epimerase
HZY77_04010	COG3252	Catalyzes the hydrolysis of methenyl-H(4)MPT( ) to 5- formyl-H(4)MPT
HZY77_04025	COG1795	PFAM Formaldehyde-activating enzyme (Fae)
HZY77_04065	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HZY77_04100	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
HZY77_04165	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
HZY77_04175	COG0375	protein maturation
HZY77_04190	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
HZY77_04200	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
HZY77_04210	COG3850	Histidine kinase
HZY77_04215	COG4263	nitrous-oxide reductase activity
HZY77_04235	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
HZY77_04270	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
HZY77_04275	COG1140	nitrate reductase beta subunit
HZY77_04280	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
HZY77_04285	COG2181	nitrate reductase activity
HZY77_04290	COG0446	pyridine nucleotide-disulphide oxidoreductase
HZY77_04305	COG0405	Gamma-glutamyltransferase
HZY77_04350	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
HZY77_04360	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
HZY77_04375	COG0058	SHG alpha-glucan phosphorylase activity
HZY77_04380	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HZY77_04385	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HZY77_04415	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
HZY77_04430	COG1280	lysine exporter protein (LysE YggA)
HZY77_04455	COG3276	selenocysteine insertion sequence binding
HZY77_04480	COG0437	4 iron, 4 sulfur cluster binding
HZY77_04505	COG0668	transmembrane transport
HZY77_04510	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
HZY77_04520	COG3942	CHAP domain
HZY77_04520	COG1388	LysM domain
HZY77_04585	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HZY77_04610	COG3177	Filamentation induced by cAMP protein fic
HZY77_04625	COG0210	DNA helicase
HZY77_04650	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
HZY77_04665	COG5654	RES domain protein
HZY77_04670	COG5642	Protein of unknown function (DUF2384)
HZY77_04675	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
HZY77_04685	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
HZY77_04695	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
HZY77_04705	COG0205	6-phosphofructokinase activity
HZY77_04715	COG0563	adenylate kinase activity
HZY77_04720	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
HZY77_04725	COG2835	tetraacyldisaccharide 4'-kinase activity
HZY77_04735	COG1663	tetraacyldisaccharide 4'-kinase activity
HZY77_04740	COG0848	biopolymer transport protein
HZY77_04745	COG0811	peptide transport
HZY77_04750	COG1570	exodeoxyribonuclease VII activity
HZY77_04755	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
HZY77_04760	COG3588	fructose-bisphosphate aldolase
HZY77_04775	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
HZY77_04785	COG0860	N-Acetylmuramoyl-L-alanine amidase
HZY77_04790	COG0802	atpase or kinase
HZY77_04805	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
HZY77_04830	COG5393	Putative Actinobacterial Holin-X, holin superfamily III
HZY77_04840	COG0180	Tryptophanyl-tRNA synthetase
HZY77_04845	COG1994	Peptidase M50
HZY77_04850	COG0009	L-threonylcarbamoyladenylate synthase
HZY77_04855	COG0613	PHP domain protein
HZY77_04860	COG2917	probably involved in intracellular septation
HZY77_04865	COG2350	Protein conserved in bacteria
HZY77_04875	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HZY77_04880	COG1923	regulation of RNA biosynthetic process
HZY77_04895	COG0463	Glycosyl transferase, family 2
HZY77_04910	COG3795	YCII-related domain
HZY77_04920	COG5507	3-demethylubiquinone-9 3-methyltransferase
HZY77_04930	COG4941	Belongs to the sigma-70 factor family
HZY77_04975	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
HZY77_04980	COG0443	Heat shock 70 kDa protein
HZY77_04985	COG0484	heat shock protein binding
HZY77_04995	COG0084	hydrolase, TatD family'
HZY77_05035	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HZY77_05040	COG1028	Short-chain dehydrogenase reductase Sdr
HZY77_05050	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HZY77_05065	COG1399	metal-binding, possibly nucleic acid-binding protein
HZY77_05075	COG5016	pyruvate
HZY77_05075	COG0511	ligase activity, forming carbon-carbon bonds
HZY77_05085	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
HZY77_05115	COG1530	ribonuclease E activity
HZY77_05120	COG3474	cytochrome
HZY77_05135	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HZY77_05140	COG0556	nucleotide-excision repair
HZY77_05145	COG0436	Aminotransferase
HZY77_05155	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HZY77_05200	COG1979	alcohol dehydrogenase
HZY77_05220	COG0673	inositol 2-dehydrogenase activity
HZY77_05225	COG0318	PFAM AMP-dependent synthetase and ligase
HZY77_05240	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HZY77_05245	COG0537	adenosine 5'-monophosphoramidase activity
HZY77_05250	COG0583	DNA-binding transcription factor activity
HZY77_05260	COG2353	YceI-like domain
HZY77_05265	COG3384	dioxygenase
HZY77_05270	COG1902	pentaerythritol trinitrate reductase activity
HZY77_05275	COG0400	carboxylic ester hydrolase activity
HZY77_05285	COG4633	Protein conserved in bacteria
HZY77_05290	COG0672	)-iron permease
HZY77_05305	COG3258	Cytochrome c
HZY77_05340	COG2032	superoxide dismutase activity
HZY77_05355	COG3852	Histidine kinase
HZY77_05395	COG1136	(ABC) transporter
HZY77_05400	COG0490	domain, Protein
HZY77_05400	COG0471	metal ion transport
HZY77_05415	COG1355	regulation of microtubule-based process
HZY77_05420	COG4585	Histidine kinase
HZY77_05425	COG2197	response regulator
HZY77_05430	COG3706	GGDEF domain
HZY77_05450	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
HZY77_05470	COG2257	FlhB HrpN YscU SpaS Family
HZY77_05475	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
HZY77_05480	COG0784	Response regulator, receiver
HZY77_05480	COG0835	chemotaxis
HZY77_05485	COG1677	Flagellar hook-basal body complex protein FliE
HZY77_05490	COG1766	The M ring may be actively involved in energy transduction
HZY77_05495	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HZY77_05510	COG2882	bacterial-type flagellum organization
HZY77_05530	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HZY77_05545	COG1987	bacterial-type flagellum assembly
HZY77_05555	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
HZY77_05565	COG2201	protein-glutamate methylesterase activity
HZY77_05570	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
HZY77_05575	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
HZY77_05580	COG0840	transmembrane signaling receptor activity
HZY77_05585	COG0840	transmembrane signaling receptor activity
HZY77_05590	COG0840	transmembrane signaling receptor activity
HZY77_05595	COG0840	transmembrane signaling receptor activity
HZY77_05605	COG0835	chemotaxis
HZY77_05610	COG0643	Histidine kinase
HZY77_05610	COG2198	Histidine kinase
HZY77_05615	COG0745	RESPONSE REGULATOR receiver
HZY77_05640	COG1706	bacterial-type flagellum-dependent cell motility
HZY77_05655	COG4787	bacterial-type flagellum-dependent cell motility
HZY77_05670	COG1558	bacterial-type flagellum-dependent cell motility
HZY77_05675	COG1815	bacterial-type flagellum-dependent cell motility
HZY77_05695	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HZY77_05695	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
HZY77_05730	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HZY77_05740	COG2169	Transcriptional regulator
HZY77_05740	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HZY77_05750	COG2048	Heterodisulfide reductase, subunit B
HZY77_05755	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
HZY77_05780	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
HZY77_05785	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
HZY77_05805	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HZY77_05810	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
HZY77_05820	COG0284	orotidine-5'-phosphate decarboxylase activity
HZY77_05825	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
HZY77_05835	COG0776	regulation of translation
HZY77_05850	COG0287	Prephenate dehydrogenase
HZY77_05855	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HZY77_05865	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HZY77_05880	COG0402	S-adenosylhomocysteine deaminase activity
HZY77_05910	COG1047	Peptidyl-prolyl cis-trans
HZY77_05935	COG2202	Pas domain
HZY77_05935	COG2205	protein histidine kinase activity
HZY77_05945	COG0784	Response regulator, receiver
HZY77_05950	COG2221	Nitrite and sulphite reductase 4Fe-4S
HZY77_05975	COG3174	membrane
HZY77_05995	COG1196	nuclear chromosome segregation
HZY77_06005	COG0308	aminopeptidase N
HZY77_06045	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
HZY77_06050	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
HZY77_06060	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HZY77_06060	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HZY77_06060	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HZY77_06070	COG2205	protein histidine kinase activity
HZY77_06075	COG0745	RESPONSE REGULATOR receiver
HZY77_06110	COG0514	ATP-dependent DNA helicase (RecQ)
HZY77_06125	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
HZY77_06135	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
HZY77_06140	COG2204	response regulator
HZY77_06155	COG1294	oxidase, subunit
HZY77_06175	COG0446	pyridine nucleotide-disulphide oxidoreductase
HZY77_06230	COG1722	exodeoxyribonuclease VII activity
HZY77_06240	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
HZY77_06245	COG1469	GTP cyclohydrolase I activity
HZY77_06250	COG3577	Aspartyl protease
HZY77_06255	COG0518	GMP synthase (glutamine-hydrolyzing) activity
HZY77_06255	COG0519	Catalyzes the synthesis of GMP from XMP
HZY77_06265	COG2046	Belongs to the sulfate adenylyltransferase family
HZY77_06305	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
HZY77_06310	COG0211	Belongs to the bacterial ribosomal protein bL27 family
HZY77_06315	COG0261	This protein binds to 23S rRNA in the presence of protein L20
HZY77_06320	COG0142	geranyltranstransferase activity
HZY77_06335	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HZY77_06360	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HZY77_06360	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HZY77_06365	COG1254	Belongs to the acylphosphatase family
HZY77_06375	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
HZY77_06390	COG1278	Cold shock
HZY77_06410	COG0482	sulfurtransferase activity
HZY77_06415	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HZY77_06420	COG0596	Alpha beta hydrolase
HZY77_06420	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HZY77_06420	COG2226	methyltransferase
HZY77_06445	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HZY77_06450	COG0625	glutathione transferase activity
HZY77_06455	COG1573	uracil-dna glycosylase
HZY77_06470	COG0436	Aminotransferase
HZY77_06480	COG1011	Hydrolase
HZY77_06485	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HZY77_06495	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
HZY77_06500	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
HZY77_06530	COG4585	Histidine kinase
HZY77_06535	COG3279	Response regulator of the LytR AlgR family
HZY77_06545	COG0542	response to heat
HZY77_06575	COG0564	pseudouridine synthase activity
HZY77_06630	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
HZY77_06635	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HZY77_06640	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HZY77_06650	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HZY77_06655	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
HZY77_06665	COG0750	zinc metalloprotease
HZY77_06675	COG0575	Belongs to the CDS family
HZY77_06680	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
HZY77_06685	COG0233	cytoplasmic translational termination
HZY77_06690	COG0528	UMP kinase activity
HZY77_06695	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
HZY77_06700	COG0052	Belongs to the universal ribosomal protein uS2 family
HZY77_06705	COG2205	protein histidine kinase activity
HZY77_06710	COG0745	RESPONSE REGULATOR receiver
HZY77_06720	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
HZY77_06735	COG1187	pseudouridine synthase activity
HZY77_06755	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HZY77_06760	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
HZY77_06785	COG3228	Belongs to the MtfA family
HZY77_06790	COG0436	Aminotransferase
HZY77_06805	COG3409	Peptidoglycan-binding domain 1 protein
HZY77_06805	COG3267	Type II secretory pathway component ExeA
HZY77_06865	COG4969	Belongs to the N-Me-Phe pilin family
HZY77_06875	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HZY77_06885	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
HZY77_06930	COG0463	Glycosyl transferase, family 2
HZY77_06940	COG0642	Histidine kinase
HZY77_06955	COG0736	holo-[acyl-carrier-protein] synthase activity
HZY77_06960	COG1472	Belongs to the glycosyl hydrolase 3 family
HZY77_07015	COG4774	siderophore transport
HZY77_07020	COG3128	pkhd-type hydroxylase
HZY77_07045	COG1573	uracil-dna glycosylase
HZY77_07055	COG0322	excinuclease ABC activity
HZY77_07085	COG2948	multi-organism process
HZY77_07110	COG3451	type IV secretory pathway VirB4
HZY77_07120	COG3838	Conjugal transfer protein Trbc
HZY77_07125	COG4962	Type ii secretion system protein e
HZY77_07145	COG0583	DNA-binding transcription factor activity
HZY77_07160	COG0842	Transport permease protein
HZY77_07165	COG1129	ABC transporter
HZY77_07165	COG0842	Transport permease protein
HZY77_07170	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HZY77_07205	COG1902	pentaerythritol trinitrate reductase activity
HZY77_07215	COG1733	regulation of RNA biosynthetic process
HZY77_07220	COG0842	Transport permease protein
HZY77_07225	COG0842	Transport permease protein
HZY77_07225	COG1129	ABC transporter
HZY77_07230	COG1129	ABC transporter
HZY77_07230	COG0842	Transport permease protein
HZY77_07255	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
HZY77_07265	COG1752	Esterase of the alpha-beta hydrolase superfamily
HZY77_07300	COG4959	Type IV secretory pathway protease TraF
HZY77_07315	COG1192	Involved in chromosome partitioning
HZY77_07340	COG1396	sequence-specific DNA binding
HZY77_07345	COG5489	Protein of unknown function (DUF736)
HZY77_07355	COG1475	DNA binding
HZY77_07365	COG2003	Belongs to the UPF0758 family
HZY77_07400	COG0779	Required for maturation of 30S ribosomal subunits
HZY77_07405	COG0195	Participates in both transcription termination and antitermination
HZY77_07405	COG2251	uridine kinase activity
HZY77_07410	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
HZY77_07410	COG3064	Membrane
HZY77_07415	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
HZY77_07420	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
HZY77_07425	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
HZY77_07430	COG1185	polyribonucleotide nucleotidyltransferase activity
HZY77_07440	COG0745	RESPONSE REGULATOR receiver
HZY77_07450	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
HZY77_07455	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HZY77_07460	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
HZY77_07480	COG3012	SEC-C Motif Domain Protein
HZY77_07490	COG4181	ATPase activity
HZY77_07495	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
HZY77_07535	COG4681	YaeQ
HZY77_07540	COG1278	Cold shock
HZY77_07560	COG1067	ATP-dependent peptidase activity
HZY77_07580	COG2200	EAL domain
HZY77_07590	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HZY77_07595	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
HZY77_07600	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HZY77_07615	COG0028	Belongs to the TPP enzyme family
HZY77_07625	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
HZY77_07635	COG0302	gtp cyclohydrolase
HZY77_07640	COG0840	transmembrane signaling receptor activity
HZY77_07645	COG0564	pseudouridine synthase activity
HZY77_07650	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
HZY77_07655	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
HZY77_07660	COG0022	dehydrogenase e1 component
HZY77_07660	COG0508	dehydrogenase complex catalyzes the overall conversion of
HZY77_07675	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HZY77_07695	COG1285	pathogenesis
HZY77_07700	COG1686	Belongs to the peptidase S11 family
HZY77_07705	COG1301	dicarboxylic acid transport
HZY77_07720	COG0686	Belongs to the AlaDH PNT family
HZY77_07725	COG0588	phosphoglycerate mutase activity
HZY77_07775	COG1518	maintenance of DNA repeat elements
HZY77_07780	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
HZY77_07785	COG3278	Belongs to the heme-copper respiratory oxidase family
HZY77_07855	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
HZY77_07860	COG0047	phosphoribosylformylglycinamidine synthase activity
HZY77_07860	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HZY77_07875	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
HZY77_07875	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
HZY77_07890	COG1210	Utp--glucose-1-phosphate uridylyltransferase
HZY77_07905	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
HZY77_07910	COG0148	phosphopyruvate hydratase activity
HZY77_07915	COG0504	CTP synthase activity
HZY77_07925	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
HZY77_07940	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HZY77_07955	COG1944	ATP diphosphatase activity
HZY77_07970	COG1683	Conserved Protein
HZY77_07975	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HZY77_07980	COG0557	exoribonuclease II activity
HZY77_07990	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
HZY77_07995	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
HZY77_08005	COG0330	HflC and HflK could
HZY77_08010	COG0330	HflC and HflK could
HZY77_08015	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
HZY77_08035	COG1160	GTP binding
HZY77_08045	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HZY77_08055	COG0124	histidyl-tRNA synthetase
HZY77_08060	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
HZY77_08075	COG0820	rRNA (adenine-C2-)-methyltransferase activity
HZY77_08080	COG0105	UTP biosynthetic process
HZY77_08085	COG0037	tRNA processing
HZY77_08100	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HZY77_08105	COG2850	peptidyl-arginine hydroxylation
HZY77_08115	COG2833	Protein of unknown function (DUF455)
HZY77_08130	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
HZY77_08145	COG0525	valine-tRNA ligase activity
HZY77_08155	COG2210	Belongs to the sulfur carrier protein TusA family
HZY77_08160	COG0425	Belongs to the sulfur carrier protein TusA family
HZY77_08165	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HZY77_08170	COG3302	dmso reductase anchor subunit
HZY77_08175	COG0437	4 iron, 4 sulfur cluster binding
HZY77_08180	COG0243	molybdopterin cofactor binding
HZY77_08200	COG4783	chaperone-mediated protein folding
HZY77_08235	COG1285	pathogenesis
HZY77_08250	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
HZY77_08285	COG1459	type II secretion system
HZY77_08335	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
HZY77_08345	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
HZY77_08350	COG1137	ATPase activity
HZY77_08355	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
HZY77_08365	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HZY77_08370	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
HZY77_08375	COG1660	Displays ATPase and GTPase activities
HZY77_08390	COG0163	prenyltransferase activity
HZY77_08410	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
HZY77_08430	COG3118	belongs to the thioredoxin family
HZY77_08440	COG0586	Pfam SNARE associated Golgi protein
HZY77_08450	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
HZY77_08470	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HZY77_08475	COG2200	EAL domain
HZY77_08480	COG0312	modulator of DNA gyrase
HZY77_08490	COG3164	Protein of unknown function
HZY77_08495	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
HZY77_08500	COG0583	DNA-binding transcription factor activity
HZY77_08505	COG1741	Belongs to the pirin family
HZY77_08520	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HZY77_08525	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
HZY77_08530	COG1846	Transcriptional regulator
HZY77_08540	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
HZY77_08545	COG0530	calcium, potassium:sodium antiporter activity
HZY77_08560	COG0668	transmembrane transport
HZY77_08565	COG0438	transferase activity, transferring glycosyl groups
HZY77_08585	COG0475	glutathione-regulated potassium exporter activity
HZY77_08605	COG0330	HflC and HflK could
HZY77_08610	COG0670	Belongs to the BI1 family
HZY77_08615	COG0084	hydrolase, TatD family'
HZY77_08630	COG2020	methyltransferase activity
HZY77_08635	COG0302	gtp cyclohydrolase
HZY77_08650	COG3300	MHYT domain
HZY77_08650	COG5001	Diguanylate cyclase
HZY77_08655	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HZY77_08660	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
HZY77_08665	COG0631	protein serine/threonine phosphatase activity
HZY77_08670	COG0515	serine threonine protein kinase
HZY77_08670	COG3266	domain, Protein
HZY77_08675	COG1561	YicC-like family, N-terminal region
HZY77_08680	COG0194	GDP metabolic process
HZY77_08685	COG1758	RNA polymerase activity
HZY77_08690	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HZY77_08700	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
HZY77_08710	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
HZY77_08750	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
HZY77_08760	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
HZY77_08765	COG0316	Belongs to the HesB IscA family
HZY77_08770	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
HZY77_08775	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
HZY77_08780	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
HZY77_08785	COG1434	Gram-negative-bacterium-type cell wall biogenesis
HZY77_08790	COG1765	OsmC-like protein
HZY77_08800	COG2321	neutral zinc metallopeptidase
HZY77_08820	COG0494	nUDIX hydrolase
HZY77_08830	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
HZY77_08850	COG0629	single-stranded DNA binding
HZY77_08855	COG2814	Major facilitator Superfamily
HZY77_08865	COG1187	pseudouridine synthase activity
HZY77_08885	COG0203	ribosomal protein L17
HZY77_08890	COG0202	RNA polymerase activity
HZY77_08895	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
HZY77_08905	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
HZY77_08910	COG0257	Belongs to the bacterial ribosomal protein bL36 family
HZY77_08915	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
HZY77_08920	COG0201	protein transport
HZY77_08925	COG0200	Binds to the 23S rRNA
HZY77_08930	COG1841	ribosomal large subunit assembly
HZY77_08935	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
HZY77_08945	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
HZY77_08950	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
HZY77_08955	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
HZY77_08960	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
HZY77_08970	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
HZY77_08975	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
HZY77_08980	COG0255	Belongs to the universal ribosomal protein uL29 family
HZY77_08985	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
HZY77_08990	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
HZY77_08995	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
HZY77_09005	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
HZY77_09010	COG0089	rRNA binding
HZY77_09020	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
HZY77_09025	COG0051	transcription antitermination factor activity, RNA binding
HZY77_09030	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
HZY77_09035	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HZY77_09040	COG0049	tRNA binding
HZY77_09050	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
HZY77_09055	COG0085	RNA polymerase activity
HZY77_09065	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
HZY77_09070	COG0081	regulation of translation
HZY77_09095	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
HZY77_09115	COG0012	GTP binding
HZY77_09125	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
HZY77_09130	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HZY77_09140	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
HZY77_09145	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
HZY77_09155	COG1136	(ABC) transporter
HZY77_09155	COG0577	efflux transmembrane transporter activity
HZY77_09160	COG1136	(ABC) transporter
HZY77_09160	COG0577	efflux transmembrane transporter activity
HZY77_09175	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
HZY77_09185	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
HZY77_09190	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
HZY77_09195	COG0742	ribosomal rna small subunit methyltransferase
HZY77_09200	COG0612	Peptidase, M16
HZY77_09205	COG0612	Peptidase, M16
HZY77_09215	COG2884	Cell division ATP-binding protein ftsE
HZY77_09225	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HZY77_09240	COG0348	domain, Protein
HZY77_09245	COG2010	Cytochrome c
HZY77_09260	COG3278	Belongs to the heme-copper respiratory oxidase family
HZY77_09265	COG1999	signal sequence binding
HZY77_09275	COG0109	protoheme IX farnesyltransferase activity
HZY77_09280	COG1612	heme a metabolic process
HZY77_09310	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
HZY77_09315	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HZY77_09330	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
HZY77_09335	COG2226	methyltransferase
HZY77_09340	COG2267	carboxylic ester hydrolase activity
HZY77_09345	COG0156	8-amino-7-oxononanoate synthase activity
HZY77_09350	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
HZY77_09360	COG1040	competence protein
HZY77_09365	COG0232	Belongs to the dGTPase family. Type 2 subfamily
HZY77_09415	COG1215	transferase activity, transferring glycosyl groups
HZY77_09420	COG0463	Glycosyl transferase, family 2
HZY77_09435	COG0457	Tetratricopeptide repeat
HZY77_09440	COG3119	arylsulfatase activity
HZY77_09455	COG0438	transferase activity, transferring glycosyl groups
HZY77_09460	COG1215	transferase activity, transferring glycosyl groups
HZY77_09480	COG0367	asparagine synthase
HZY77_09510	COG0438	transferase activity, transferring glycosyl groups
HZY77_09520	COG0367	asparagine synthase
HZY77_09555	COG3409	Peptidoglycan-binding domain 1 protein
HZY77_09555	COG3267	Type II secretory pathway component ExeA
HZY77_09565	COG0489	protein tyrosine kinase activity
HZY77_09595	COG1131	(ABC) transporter
HZY77_09610	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
HZY77_09620	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HZY77_09625	COG0321	lipoyl(octanoyl) transferase activity
HZY77_09630	COG2921	Belongs to the UPF0250 family
HZY77_09640	COG1686	Belongs to the peptidase S11 family
HZY77_09655	COG0768	penicillin binding
HZY77_09670	COG1077	Cell shape determining protein MreB Mrl
HZY77_09675	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HZY77_09680	COG0154	amidase activity
HZY77_09685	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HZY77_09695	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
HZY77_09700	COG0708	Exodeoxyribonuclease III
HZY77_09705	COG3645	SOS response
HZY77_09710	COG1002	Type II restriction enzyme, methylase subunits
HZY77_09715	COG3177	Filamentation induced by cAMP protein fic
HZY77_09720	COG2211	Major facilitator Superfamily
HZY77_09750	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
HZY77_09755	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
HZY77_09765	COG0840	transmembrane signaling receptor activity
HZY77_09810	COG3132	Protein of unknown function, DUF480
HZY77_09815	COG1881	PFAM PEBP family protein
HZY77_09820	COG1752	Esterase of the alpha-beta hydrolase superfamily
HZY77_09825	COG1132	(ABC) transporter
HZY77_09835	COG1999	signal sequence binding
HZY77_09855	COG3550	peptidyl-serine autophosphorylation
HZY77_09865	COG0439	Biotin carboxylase
HZY77_09870	COG3665	Urea carboxylase-associated protein
HZY77_09875	COG0864	Transcriptional regulator
HZY77_09890	COG1116	anion transmembrane transporter activity
HZY77_09895	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HZY77_09900	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HZY77_09905	COG0004	ammonium transporteR
HZY77_09925	COG0606	chelatase, subunit chli
HZY77_09950	COG0646	methionine synthase
HZY77_09950	COG1410	methionine synthase
HZY77_09970	COG3275	phosphorelay sensor kinase activity
HZY77_09975	COG0165	Argininosuccinate lyase
HZY77_09985	COG1965	Belongs to the frataxin family
HZY77_10005	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
HZY77_10020	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
HZY77_10025	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
HZY77_10030	COG2354	Protein conserved in bacteria
HZY77_10040	COG3447	MASE1 domain protein
HZY77_10040	COG5001	Diguanylate cyclase
HZY77_10040	COG5002	protein histidine kinase activity
HZY77_10045	COG0277	FAD linked oxidase domain protein
HZY77_10065	COG0745	RESPONSE REGULATOR receiver
HZY77_10070	COG2226	methyltransferase
HZY77_10080	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
HZY77_10085	COG4235	cytochrome complex assembly
HZY77_10120	COG4133	protoheme IX ABC transporter activity
HZY77_10160	COG0492	ferredoxin-NADP+ reductase activity
HZY77_10190	COG0457	Tetratricopeptide repeat
HZY77_10195	COG0457	Tetratricopeptide repeat
HZY77_10205	COG2046	Belongs to the sulfate adenylyltransferase family
HZY77_10205	COG0529	Catalyzes the synthesis of activated sulfate
HZY77_10225	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
HZY77_10265	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HZY77_10270	COG2198	Histidine kinase
HZY77_10270	COG2205	protein histidine kinase activity
HZY77_10270	COG0784	Response regulator, receiver
HZY77_10310	COG0218	Necessary for normal cell division and for the maintenance of normal septation
HZY77_10320	COG1333	cytochrome c biogenesis protein
HZY77_10325	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HZY77_10330	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HZY77_10335	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
HZY77_10340	COG0439	Biotin carboxylase
HZY77_10345	COG2264	protein methyltransferase activity
HZY77_10355	COG0404	The glycine cleavage system catalyzes the degradation of glycine
HZY77_10360	COG0509	glycine decarboxylation via glycine cleavage system
HZY77_10365	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HZY77_10380	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HZY77_10395	COG0438	transferase activity, transferring glycosyl groups
HZY77_10400	COG0671	phosphoesterase, PA-phosphatase related
HZY77_10410	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HZY77_10430	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
HZY77_10445	COG2860	membrane
HZY77_10455	COG0191	fructose-bisphosphate aldolase activity
HZY77_10460	COG0469	pyruvate kinase activity
HZY77_10465	COG0126	phosphoglycerate kinase activity
HZY77_10470	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HZY77_10475	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
HZY77_10495	COG1385	rRNA (uridine-N3-)-methyltransferase activity
HZY77_10520	COG0488	(ABC) transporter
HZY77_10535	COG3001	Fructosamine kinase
HZY77_10540	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
HZY77_10605	COG3245	cytochrome
HZY77_10705	COG0653	protein targeting
HZY77_10720	COG2885	chlorophyll binding
HZY77_10730	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
HZY77_10735	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
HZY77_10745	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
HZY77_10750	COG1181	Belongs to the D-alanine--D-alanine ligase family
HZY77_10760	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HZY77_10775	COG0772	Belongs to the SEDS family
HZY77_10780	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
HZY77_10785	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HZY77_10790	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
HZY77_10795	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HZY77_10810	COG0275	rRNA processing
HZY77_10815	COG2001	Belongs to the MraZ family
HZY77_10830	COG0418	dihydroorotase activity
HZY77_10840	COG0792	nuclease activity
HZY77_10845	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
HZY77_10850	COG2823	Periplasmic or secreted lipoprotein
HZY77_10855	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
HZY77_10860	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
HZY77_10865	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
HZY77_10870	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
HZY77_10875	COG3134	Outer membrane lipoprotein
HZY77_10885	COG2027	D-alanyl-D-alanine carboxypeptidase
HZY77_10895	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HZY77_10915	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
HZY77_10930	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HZY77_10940	COG1309	transcriptional regulator
HZY77_10950	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HZY77_11020	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
HZY77_11025	COG0459	protein refolding
HZY77_11040	COG2176	DNA-directed DNA polymerase activity
HZY77_11045	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HZY77_11070	COG3647	Membrane
HZY77_11105	COG2304	oxidoreductase activity
HZY77_11120	COG0714	Associated with various cellular activities
HZY77_11135	COG0842	Transport permease protein
HZY77_11160	COG3852	Histidine kinase
HZY77_11165	COG1686	Belongs to the peptidase S11 family
HZY77_11175	COG2084	Dehydrogenase
HZY77_11200	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HZY77_11210	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HZY77_11225	COG2951	lytic endotransglycosylase activity
HZY77_11245	COG1752	Esterase of the alpha-beta hydrolase superfamily
HZY77_11250	COG2827	Endonuclease containing a URI domain
HZY77_11290	COG2943	transferase activity, transferring hexosyl groups
HZY77_11305	COG1414	Transcriptional regulator
HZY77_11320	COG0277	FAD linked oxidase domain protein
HZY77_11325	COG0277	FAD linked oxidase domain protein
HZY77_11335	COG0247	lactate metabolic process
HZY77_11345	COG0746	molybdenum cofactor guanylyltransferase activity
HZY77_11360	COG0254	rRNA binding
HZY77_11365	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
HZY77_11385	COG1074	ATP-dependent DNA helicase activity
HZY77_11405	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
HZY77_11420	COG0022	dehydrogenase e1 component
HZY77_11420	COG0508	dehydrogenase complex catalyzes the overall conversion of
HZY77_11425	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
HZY77_11440	COG0352	thiamine-phosphate diphosphorylase activity
HZY77_11450	COG0704	Plays a role in the regulation of phosphate uptake
HZY77_11455	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
HZY77_11465	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HZY77_11470	COG0569	domain protein
HZY77_11480	COG5000	phosphorelay sensor kinase activity
HZY77_11490	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
HZY77_11490	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HZY77_11495	COG0501	Belongs to the peptidase M48B family
HZY77_11500	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
HZY77_11505	COG0242	peptide deformylase activity
HZY77_11510	COG1652	LysM domain
HZY77_11515	COG2922	Belongs to the Smg family
HZY77_11545	COG0471	metal ion transport
HZY77_11555	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HZY77_11565	COG0592	DNA-directed DNA polymerase activity
HZY77_11570	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
HZY77_11575	COG0230	Belongs to the bacterial ribosomal protein bL34 family
HZY77_11585	COG0706	membrane insertase activity
HZY77_11610	COG0513	Belongs to the DEAD box helicase family
HZY77_11615	COG3706	GGDEF domain
HZY77_11625	COG1984	allophanate hydrolase subunit 2
HZY77_11640	COG0445	tRNA wobble uridine modification
HZY77_11665	COG0356	it plays a direct role in the translocation of protons across the membrane
HZY77_11675	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
HZY77_11680	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HZY77_11685	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
HZY77_11690	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
HZY77_11695	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
HZY77_11700	COG0355	proton-transporting ATP synthase activity, rotational mechanism
HZY77_11710	COG2201	protein-glutamate methylesterase activity
HZY77_11720	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
HZY77_11730	COG2197	response regulator
HZY77_11740	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HZY77_11750	COG0018	arginyl-trna synthetase
HZY77_11755	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
HZY77_11760	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
HZY77_11770	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
HZY77_11810	COG2204	response regulator
HZY77_11815	COG2205	protein histidine kinase activity
HZY77_11820	COG0493	'glutamate synthase
HZY77_11825	COG0067	glutamate synthase
HZY77_11825	COG0070	glutamate synthase
HZY77_11825	COG0069	glutamate synthase activity
HZY77_11855	COG2080	2 iron, 2 sulfur cluster binding
HZY77_11890	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
HZY77_11895	COG0129	dihydroxy-acid dehydratase activity
HZY77_11910	COG1331	Highly conserved protein containing a thioredoxin domain
HZY77_11920	COG4654	Cytochrome c, class I
HZY77_11940	COG0411	ABC transporter
HZY77_11945	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
HZY77_11965	COG4771	TonB-dependent receptor
HZY77_11995	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
HZY77_12005	COG0438	transferase activity, transferring glycosyl groups
HZY77_12030	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HZY77_12040	COG4535	Mg2 and Co2 transporter CorC
HZY77_12060	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
HZY77_12080	COG0477	Major facilitator Superfamily
HZY77_12095	COG2944	sequence-specific DNA binding
HZY77_12115	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HZY77_12120	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
HZY77_12125	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
HZY77_12130	COG3706	GGDEF domain
HZY77_12135	COG1968	undecaprenyl-diphosphatase activity
HZY77_12170	COG3220	belongs to the UPF0276 family
HZY77_12195	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
HZY77_12205	COG0730	response to heat
HZY77_12215	COG2198	Histidine kinase
HZY77_12215	COG0784	Response regulator, receiver
HZY77_12215	COG2205	protein histidine kinase activity
HZY77_12230	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
HZY77_12235	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
HZY77_12240	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
HZY77_12260	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
HZY77_12265	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
HZY77_12275	COG2920	part of a sulfur-relay system
HZY77_12295	COG1850	ribulose-bisphosphate carboxylase activity
HZY77_12310	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
HZY77_12320	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
HZY77_12325	COG0366	Alpha amylase catalytic
HZY77_12330	COG5001	Diguanylate cyclase
HZY77_12330	COG3300	MHYT domain
HZY77_12335	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HZY77_12340	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HZY77_12360	COG1262	PFAM Formylglycine-generating sulfatase enzyme
HZY77_12370	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HZY77_12375	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
HZY77_12375	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HZY77_12405	COG1192	Involved in chromosome partitioning
HZY77_12465	COG3002	Belongs to the UPF0753 family
HZY77_12470	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HZY77_12475	COG0583	DNA-binding transcription factor activity
HZY77_12485	COG3002	Belongs to the UPF0753 family
HZY77_12495	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HZY77_12500	COG0583	DNA-binding transcription factor activity
HZY77_12505	COG1850	ribulose-bisphosphate carboxylase activity
HZY77_12510	COG4451	ribulose bisphosphate carboxylase, small
HZY77_12530	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
HZY77_12535	COG3260	NADH ubiquinone oxidoreductase 20
HZY77_12545	COG0651	ATP synthesis coupled electron transport
HZY77_12560	COG0651	ATP synthesis coupled electron transport
HZY77_12580	COG0446	pyridine nucleotide-disulphide oxidoreductase
HZY77_12590	COG3118	belongs to the thioredoxin family
HZY77_12600	COG0583	DNA-binding transcription factor activity
HZY77_12605	COG0501	Belongs to the peptidase M48B family
HZY77_12610	COG0861	Integral membrane protein TerC family
HZY77_12615	COG0628	permease
HZY77_12630	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
HZY77_12630	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HZY77_12635	COG1022	Amp-dependent synthetase and ligase
HZY77_12640	COG2067	long-chain fatty acid transport protein
HZY77_12645	COG1511	domain protein
HZY77_12645	COG3264	Mechanosensitive ion channel
HZY77_12655	COG0267	Belongs to the bacterial ribosomal protein bL33 family
HZY77_12660	COG0227	Belongs to the bacterial ribosomal protein bL28 family
HZY77_12665	COG2003	Belongs to the UPF0758 family
HZY77_12670	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
HZY77_12675	COG0756	dUTP diphosphatase activity
HZY77_12685	COG0815	Transfers the fatty acyl group on membrane lipoproteins
HZY77_12695	COG0540	Belongs to the ATCase OTCase family
HZY77_12700	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
HZY77_12705	COG1678	Uncharacterized ACR, COG1678
HZY77_12710	COG0415	Belongs to the DNA photolyase family
HZY77_12735	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
HZY77_12755	COG3150	esterase
HZY77_12785	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HZY77_12785	COG1116	anion transmembrane transporter activity
HZY77_12790	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HZY77_12795	COG1116	anion transmembrane transporter activity
HZY77_12800	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
HZY77_12810	COG0697	spore germination
HZY77_12830	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HZY77_12835	COG2205	protein histidine kinase activity
HZY77_12850	COG0181	hydroxymethylbilane synthase activity
HZY77_12875	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HZY77_12875	COG0543	2 iron, 2 sulfur cluster binding
HZY77_12895	COG4232	protein-disulfide reductase activity
HZY77_12905	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
HZY77_12915	COG0351	phosphomethylpyrimidine kinase
HZY77_12950	COG2198	Histidine kinase
HZY77_12950	COG0784	Response regulator, receiver
HZY77_12950	COG0643	Histidine kinase
HZY77_12970	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
HZY77_12975	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
HZY77_13005	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
HZY77_13010	COG0523	cobalamin synthesis protein
HZY77_13030	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HZY77_13040	COG5001	Diguanylate cyclase
HZY77_13040	COG5002	protein histidine kinase activity
HZY77_13045	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
HZY77_13055	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
HZY77_13060	COG1832	CoA-binding protein
HZY77_13070	COG1560	Kdo2-lipid A biosynthetic process
HZY77_13080	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
HZY77_13090	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
HZY77_13095	COG1950	PFAM Membrane protein of
HZY77_13100	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
HZY77_13105	COG1253	flavin adenine dinucleotide binding
HZY77_13125	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
HZY77_13130	COG0037	tRNA processing
HZY77_13135	COG1132	(ABC) transporter
HZY77_13145	COG0598	Magnesium transport protein CorA
HZY77_13195	COG2274	protein secretion by the type I secretion system
HZY77_13205	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HZY77_13210	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
HZY77_13220	COG0174	glutamine synthetase
HZY77_13230	COG3852	Histidine kinase
HZY77_13235	COG2204	response regulator
HZY77_13240	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
HZY77_13265	COG2890	protein-(glutamine-N5) methyltransferase activity
HZY77_13270	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
HZY77_13275	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
HZY77_13295	COG2920	part of a sulfur-relay system
HZY77_13310	COG2221	Nitrite and sulphite reductase 4Fe-4S
HZY77_13315	COG2221	Nitrite and sulphite reductase 4Fe-4S
HZY77_13320	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
HZY77_13325	COG2923	Belongs to the DsrF TusC family
HZY77_13335	COG2920	part of a sulfur-relay system
HZY77_13370	COG1797	cobyrinic acid a,c-diamide synthase activity
HZY77_13380	COG1648	precorrin-2 dehydrogenase activity
HZY77_13380	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
HZY77_13385	COG4651	solute:proton antiporter activity
HZY77_13385	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HZY77_13390	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
HZY77_13390	COG0674	pyruvate-flavodoxin oxidoreductase activity
HZY77_13390	COG1013	pyruvate-flavodoxin oxidoreductase activity
HZY77_13390	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
HZY77_13415	COG2197	response regulator
HZY77_13420	COG3850	Histidine kinase
HZY77_13435	COG0247	lactate metabolic process
HZY77_13440	COG0583	DNA-binding transcription factor activity
HZY77_13450	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
HZY77_13475	COG0028	Belongs to the TPP enzyme family
HZY77_13500	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HZY77_13515	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HZY77_13580	COG0009	L-threonylcarbamoyladenylate synthase
HZY77_13585	COG0151	Belongs to the GarS family
HZY77_13590	COG0138	bifunctional purine biosynthesis protein purh
HZY77_13595	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
HZY77_13605	COG1970	mechanosensitive ion channel activity
HZY77_13670	COG2204	response regulator
HZY77_13675	COG4191	Histidine kinase
HZY77_13710	COG0210	DNA helicase
HZY77_13740	COG0495	leucyl-tRNA aminoacylation
HZY77_13755	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
HZY77_13760	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
HZY77_13765	COG0799	negative regulation of ribosome biogenesis
HZY77_13770	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
HZY77_13775	COG0424	maF-like protein
HZY77_13780	COG1530	ribonuclease E activity
HZY77_13790	COG0730	response to heat
HZY77_13800	COG0411	ABC transporter
HZY77_13805	COG1172	Belongs to the binding-protein-dependent transport system permease family
HZY77_13825	COG0339	signal peptide processing
HZY77_13830	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
HZY77_13835	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HZY77_13840	COG0488	(ABC) transporter
HZY77_13845	COG3706	GGDEF domain
HZY77_13850	COG2731	YhcH YjgK YiaL family protein
HZY77_13900	COG0762	integral membrane protein
HZY77_13910	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
HZY77_13915	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HZY77_13920	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HZY77_13950	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
HZY77_13955	COG0840	transmembrane signaling receptor activity
HZY77_13965	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
HZY77_13975	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
HZY77_13985	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
HZY77_14010	COG1959	2 iron, 2 sulfur cluster binding
HZY77_14050	COG0640	Transcriptional regulator
HZY77_14055	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
HZY77_14060	COG4942	peptidase
HZY77_14065	COG0793	Belongs to the peptidase S41A family
HZY77_14075	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HZY77_14090	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HZY77_14100	COG1610	YqeY-like protein
HZY77_14105	COG0828	Belongs to the bacterial ribosomal protein bS21 family
HZY77_14110	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
HZY77_14120	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
HZY77_14140	COG4974	Belongs to the 'phage' integrase family
HZY77_14145	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HZY77_14155	COG0335	large ribosomal subunit rRNA binding
HZY77_14160	COG0336	Belongs to the RNA methyltransferase TrmD family
HZY77_14165	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
HZY77_14170	COG0228	four-way junction DNA binding
HZY77_14175	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
HZY77_14180	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HZY77_14185	COG4536	flavin adenine dinucleotide binding
HZY77_14205	COG0237	dephospho-CoA kinase activity
HZY77_14210	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
HZY77_14215	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
HZY77_14225	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HZY77_14240	COG0617	tRNA 3'-terminal CCA addition
HZY77_14250	COG3158	transport of potassium into the cell
HZY77_14285	COG0010	Belongs to the arginase family
HZY77_14315	COG2205	protein histidine kinase activity
HZY77_14330	COG1969	Ni Fe-hydrogenase, b-type cytochrome subunit
HZY77_14335	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
HZY77_14345	COG0751	glycine-tRNA ligase activity
HZY77_14350	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
HZY77_14375	COG2885	chlorophyll binding
HZY77_14375	COG3047	cAMP biosynthetic process
HZY77_14385	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
HZY77_14390	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HZY77_14395	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
HZY77_14405	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
HZY77_14410	COG0006	proline dipeptidase activity
HZY77_14420	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HZY77_14460	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
HZY77_14470	COG0583	DNA-binding transcription factor activity
HZY77_14480	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
HZY77_14505	COG0583	DNA-binding transcription factor activity
HZY77_14525	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HZY77_14535	COG1592	Rubrerythrin
HZY77_14545	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HZY77_14550	COG0789	Transcriptional regulator
HZY77_14560	COG0720	synthase
HZY77_14595	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HZY77_14595	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HZY77_14600	COG2814	Major facilitator Superfamily
HZY77_14610	COG1253	flavin adenine dinucleotide binding
HZY77_14615	COG0071	Belongs to the small heat shock protein (HSP20) family
HZY77_14660	COG0243	molybdopterin cofactor binding
HZY77_14670	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HZY77_14680	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
HZY77_14690	COG0850	regulation of cytokinetic process
HZY77_14695	COG1116	anion transmembrane transporter activity
HZY77_14700	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HZY77_14710	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HZY77_14740	COG2217	Heavy metal translocating P-type atpase
HZY77_14775	COG0753	catalase activity
HZY77_14780	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
HZY77_14785	COG2982	Protein involved in outer membrane biogenesis
HZY77_14790	COG0628	permease
HZY77_14820	COG2323	membrane
HZY77_14840	COG3258	Cytochrome c
HZY77_14855	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HZY77_14875	COG5487	UPF0391 membrane protein
HZY77_14885	COG2197	response regulator
HZY77_14890	COG3279	Response regulator of the LytR AlgR family
HZY77_14910	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
HZY77_14915	COG2967	ApaG domain
HZY77_14925	COG0546	phosphoglycolate phosphatase activity
HZY77_14940	COG2223	nitrite transmembrane transporter activity
HZY77_14945	COG2207	Transcriptional regulator
HZY77_14950	COG0519	Catalyzes the synthesis of GMP from XMP
HZY77_14985	COG0446	pyridine nucleotide-disulphide oxidoreductase
HZY77_15020	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HZY77_15025	COG0134	indole-3-glycerol-phosphate synthase activity
HZY77_15030	COG0433	COG0433 Predicted ATPase
HZY77_15035	COG1252	NADH dehydrogenase
HZY77_15040	COG1940	carbohydrate kinase activity
HZY77_15045	COG0217	transcriptional regulatory protein
HZY77_15050	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
HZY77_15055	COG0632	four-way junction helicase activity
HZY77_15060	COG3706	GGDEF domain
HZY77_15065	COG2255	four-way junction helicase activity
HZY77_15070	COG0824	Thioesterase
HZY77_15105	COG0602	queuosine metabolic process
HZY77_15110	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
HZY77_15135	COG2137	regulation of response to DNA damage stimulus
HZY77_15140	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
HZY77_15150	COG1546	Belongs to the CinA family
HZY77_15155	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
HZY77_15165	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HZY77_15170	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
HZY77_15195	COG0826	peptidase U32
HZY77_15200	COG0826	peptidase U32
HZY77_15205	COG0720	synthase
HZY77_15210	COG3154	lipid carrier protein
HZY77_15260	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
HZY77_15260	COG1328	CTP reductase activity
HZY77_15275	COG2226	methyltransferase
HZY77_15280	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HZY77_15280	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HZY77_15285	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
HZY77_15290	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
HZY77_15295	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
HZY77_15300	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
HZY77_15310	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
HZY77_15315	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
HZY77_15330	COG2010	Cytochrome c
HZY77_15370	COG1032	radical SAM domain protein
HZY77_15380	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
HZY77_15395	COG0312	modulator of DNA gyrase
HZY77_15400	COG3028	Belongs to the UPF0307 family
HZY77_15420	COG0521	Mo-molybdopterin cofactor biosynthetic process
HZY77_15435	COG0598	Magnesium transport protein CorA
HZY77_15445	COG5002	protein histidine kinase activity
HZY77_15445	COG5001	Diguanylate cyclase
HZY77_15460	COG0429	hydrolase of the alpha beta-hydrolase fold
HZY77_15485	COG5001	Diguanylate cyclase
HZY77_15485	COG3300	MHYT domain
HZY77_15500	COG1194	a g-specific adenine glycosylase
HZY77_15530	COG0220	tRNA (guanine-N7-)-methyltransferase activity
HZY77_15535	COG2095	MarC family integral membrane protein
HZY77_15540	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
HZY77_15545	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
HZY77_15550	COG0363	glucosamine-6-phosphate deaminase activity
HZY77_15560	COG1027	Aspartate ammonia-lyase
HZY77_15565	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HZY77_15590	COG0741	lytic transglycosylase activity
HZY77_15595	COG0442	prolyl-tRNA aminoacylation
HZY77_15600	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
HZY77_15615	COG0494	nUDIX hydrolase
HZY77_15625	COG0489	protein tyrosine kinase activity
HZY77_15635	COG1982	Orn Lys Arg decarboxylase major
HZY77_15640	COG0360	Binds together with S18 to 16S ribosomal RNA
HZY77_15650	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
HZY77_15655	COG0359	binds to the 23S rRNA
HZY77_15665	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HZY77_15685	COG0354	folic acid binding
HZY77_15695	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
HZY77_15700	COG1595	DNA-templated transcription, initiation
HZY77_15720	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HZY77_15730	COG0481	GTPase activity
HZY77_15735	COG0681	Belongs to the peptidase S26 family
HZY77_15745	COG0571	ribonuclease III activity
HZY77_15750	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
HZY77_15760	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
HZY77_15780	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HZY77_15785	COG1862	Preprotein translocase
HZY77_15790	COG0343	queuine tRNA-ribosyltransferase activity
HZY77_15805	COG3177	Filamentation induced by cAMP protein fic
HZY77_15825	COG3152	Membrane
HZY77_15845	COG1215	transferase activity, transferring glycosyl groups
HZY77_15850	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HZY77_15855	COG0166	Belongs to the GPI family
HZY77_15860	COG0837	glucose binding
HZY77_15865	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
HZY77_15880	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
HZY77_15885	COG0297	glycogen (starch) synthase activity
HZY77_15890	COG0058	SHG alpha-glucan phosphorylase activity
HZY77_15895	COG2076	Multidrug Resistance protein
HZY77_15900	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
HZY77_15905	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
HZY77_15910	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
HZY77_15915	COG1428	Deoxynucleoside kinase
HZY77_15920	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
HZY77_15940	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HZY77_15960	COG3047	cAMP biosynthetic process
HZY77_15965	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
HZY77_15970	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
HZY77_15980	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
HZY77_16010	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
HZY77_16015	COG1420	regulation of RNA biosynthetic process
HZY77_16020	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
HZY77_16025	COG0497	DNA recombination
HZY77_16055	COG0123	including yeast histone deacetylase and acetoin utilization protein
HZY77_16075	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
HZY77_16085	COG4660	Part of a membrane complex involved in electron transport
HZY77_16105	COG2878	Part of a membrane complex involved in electron transport
HZY77_16110	COG4657	Part of a membrane complex involved in electron transport
HZY77_16140	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HZY77_16165	COG1643	Atp-dependent helicase
HZY77_16170	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HZY77_16180	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HZY77_16340	COG0277	FAD linked oxidase domain protein
HZY77_16380	COG0028	Belongs to the TPP enzyme family
HZY77_16385	COG0440	acetolactate synthase activity
HZY77_16390	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
HZY77_16395	COG0688	phosphatidylethanolamine metabolic process
HZY77_16400	COG1183	phosphatidylcholine synthase activity
HZY77_16405	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HZY77_16410	COG0697	spore germination
HZY77_16420	COG0300	oxidoreductase activity
HZY77_16455	COG4191	Histidine kinase
HZY77_16470	COG1234	tRNA 3'-trailer cleavage
HZY77_16490	COG0788	formyltetrahydrofolate deformylase activity
HZY77_16495	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HZY77_16495	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
HZY77_16500	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HZY77_16540	COG2326	polyphosphate kinase activity
HZY77_16560	COG3706	GGDEF domain
HZY77_16570	COG1733	regulation of RNA biosynthetic process
HZY77_16575	COG2020	methyltransferase activity
HZY77_16585	COG3813	Protein conserved in bacteria
HZY77_16640	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HZY77_16655	COG0820	rRNA (adenine-C2-)-methyltransferase activity
HZY77_16660	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
HZY77_16670	COG2183	response to ionizing radiation
HZY77_16700	COG5001	Diguanylate cyclase
HZY77_16700	COG5002	protein histidine kinase activity
HZY77_16705	COG0667	Aldo Keto reductase
HZY77_16725	COG1350	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
HZY77_16735	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HZY77_16735	COG1017	nitric oxide dioxygenase activity
HZY77_16745	COG3647	Membrane
HZY77_16765	COG3706	GGDEF domain
HZY77_16785	COG1132	(ABC) transporter
HZY77_16790	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HZY77_16790	COG0189	ligase activity
HZY77_16795	COG1181	Belongs to the D-alanine--D-alanine ligase family
HZY77_16795	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HZY77_16845	COG2920	part of a sulfur-relay system
HZY77_16855	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HZY77_16865	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
HZY77_16875	COG0066	3-isopropylmalate dehydratase activity
HZY77_16880	COG0473	3-isopropylmalate dehydrogenase activity
HZY77_16910	COG0133	tryptophan synthase activity
HZY77_16915	COG0159	tryptophan synthase activity
HZY77_16920	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
HZY77_16925	COG0285	dihydrofolate synthase activity
HZY77_16955	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HZY77_16970	COG0215	cysteine-tRNA ligase activity
HZY77_16980	COG1127	ABC transporter
HZY77_17010	COG1131	(ABC) transporter
HZY77_17020	COG0271	Belongs to the BolA IbaG family
HZY77_17025	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
HZY77_17030	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
HZY77_17035	COG0367	asparagine synthase
HZY77_17045	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HZY77_17060	COG2226	methyltransferase
HZY77_17125	COG0438	transferase activity, transferring glycosyl groups
HZY77_17190	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
HZY77_17195	COG1047	Peptidyl-prolyl cis-trans
HZY77_17200	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
HZY77_17205	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
HZY77_17220	COG0268	Binds directly to 16S ribosomal RNA
HZY77_17235	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HZY77_17240	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
HZY77_17250	COG0137	argininosuccinate synthase activity
HZY77_17255	COG3123	guanosine phosphorylase activity
HZY77_17265	COG1666	GTP binding
HZY77_17275	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
HZY77_17275	COG0617	tRNA 3'-terminal CCA addition
HZY77_17275	COG0517	IMP dehydrogenase activity
HZY77_17285	COG1162	GTPase activity
HZY77_17290	COG2154	pterin-4-alpha-carbinolamine dehydratase
HZY77_17300	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
HZY77_17325	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HZY77_17330	COG0723	plastoquinol--plastocyanin reductase activity
HZY77_17335	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
HZY77_17345	COG0625	glutathione transferase activity
HZY77_17350	COG2969	positive regulation of protein catabolic process
HZY77_17385	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HZY77_17430	COG0653	protein targeting
HZY77_17435	COG4106	trans-aconitate 2-methyltransferase activity
HZY77_17460	COG2885	chlorophyll binding
HZY77_17460	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety