locus-tag	class	description
AKL02_000015	COG1091	dTDP-4-dehydrorhamnose reductase activity
AKL02_000030	COG3806	Anti-sigma factor
AKL02_000035	COG1595	DNA-templated transcription, initiation
AKL02_000050	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
AKL02_000060	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
AKL02_000090	COG1968	undecaprenyl-diphosphatase activity
AKL02_000110	COG1024	Enoyl-CoA hydratase
AKL02_000115	COG1012	belongs to the aldehyde dehydrogenase family
AKL02_000120	COG1653	transport
AKL02_000125	COG1175	transmembrane transport
AKL02_000130	COG0395	ABC-type sugar transport system, permease component
AKL02_000135	COG3842	ATPase activity
AKL02_000155	COG1609	Transcriptional regulator
AKL02_000160	COG0673	inositol 2-dehydrogenase activity
AKL02_000165	COG1053	succinate dehydrogenase
AKL02_000170	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AKL02_000200	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
AKL02_000205	COG0174	glutamine synthetase
AKL02_000225	COG4208	sulfate ABC transporter
AKL02_000235	COG3842	ATPase activity
AKL02_000245	COG0586	Pfam SNARE associated Golgi protein
AKL02_000250	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
AKL02_000255	COG0517	IMP dehydrogenase activity
AKL02_000255	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
AKL02_000270	COG1137	ATPase activity
AKL02_000275	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
AKL02_000280	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
AKL02_000310	COG1210	Utp--glucose-1-phosphate uridylyltransferase
AKL02_000315	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
AKL02_000320	COG1218	3'(2'),5'-bisphosphate nucleotidase
AKL02_000330	COG1609	Transcriptional regulator
AKL02_000350	COG0019	diaminopimelate decarboxylase activity
AKL02_000370	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
AKL02_000385	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
AKL02_000390	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
AKL02_000400	COG2226	methyltransferase
AKL02_000405	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
AKL02_000435	COG3034	peptidoglycan biosynthetic process
AKL02_000445	COG1132	(ABC) transporter
AKL02_000450	COG0617	tRNA 3'-terminal CCA addition
AKL02_000455	COG0494	nUDIX hydrolase
AKL02_000465	COG0494	nUDIX hydrolase
AKL02_000480	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
AKL02_000495	COG0137	argininosuccinate synthase activity
AKL02_000500	COG0521	Mo-molybdopterin cofactor biosynthetic process
AKL02_000505	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
AKL02_000515	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
AKL02_000520	COG0779	Required for maturation of 30S ribosomal subunits
AKL02_000535	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
AKL02_000540	COG0494	nUDIX hydrolase
AKL02_000545	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
AKL02_000550	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
AKL02_000555	COG0653	protein targeting
AKL02_000565	COG2003	Belongs to the UPF0758 family
AKL02_000585	COG3239	Fatty acid desaturase
AKL02_000590	COG1194	a g-specific adenine glycosylase
AKL02_000600	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
AKL02_000605	COG1663	tetraacyldisaccharide 4'-kinase activity
AKL02_000625	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
AKL02_000635	COG0285	dihydrofolate synthase activity
AKL02_000640	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
AKL02_000660	COG1815	bacterial-type flagellum-dependent cell motility
AKL02_000665	COG1558	bacterial-type flagellum-dependent cell motility
AKL02_000670	COG1677	Flagellar hook-basal body complex protein FliE
AKL02_000675	COG1987	bacterial-type flagellum assembly
AKL02_000680	COG4786	Flagellar basal body rod
AKL02_000685	COG4786	Flagellar basal body rod
AKL02_000695	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
AKL02_000710	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
AKL02_000720	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
AKL02_000735	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
AKL02_000755	COG1766	The M ring may be actively involved in energy transduction
AKL02_000765	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
AKL02_000770	COG1338	Plays a role in the flagellum-specific transport system
AKL02_000780	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
AKL02_000785	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
AKL02_000795	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
AKL02_000800	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
AKL02_000810	COG0306	phosphate transporter
AKL02_000815	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
AKL02_000820	COG1335	isochorismatase
AKL02_000825	COG1054	Belongs to the UPF0176 family
AKL02_000845	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
AKL02_000850	COG1671	Belongs to the UPF0178 family
AKL02_000860	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
AKL02_000865	COG0142	geranyltranstransferase activity
AKL02_000880	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
AKL02_000890	COG3770	Murein endopeptidase that cleaves the D-alanyl-meso-2,6- diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus
AKL02_000895	COG2270	Major facilitator Superfamily
AKL02_000905	COG0514	ATP-dependent DNA helicase (RecQ)
AKL02_000910	COG5002	protein histidine kinase activity
AKL02_000910	COG2205	protein histidine kinase activity
AKL02_000910	COG0784	Response regulator, receiver
AKL02_000915	COG0183	Belongs to the thiolase family
AKL02_000925	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
AKL02_000930	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
AKL02_000940	COG0560	Phosphoserine phosphatase
AKL02_000945	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
AKL02_000955	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AKL02_000960	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
AKL02_000965	COG4134	Bacterial extracellular solute-binding protein
AKL02_000970	COG4135	transport system, permease component
AKL02_000975	COG4136	ATPase activity
AKL02_000995	COG0318	PFAM AMP-dependent synthetase and ligase
AKL02_001010	COG1024	Enoyl-CoA hydratase
AKL02_001010	COG1250	3-hydroxyacyl-CoA dehydrogenase
AKL02_001015	COG0183	Belongs to the thiolase family
AKL02_001040	COG1960	acyl-CoA dehydrogenase activity
AKL02_001055	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
AKL02_001065	COG0154	amidase activity
AKL02_001080	COG0446	pyridine nucleotide-disulphide oxidoreductase
AKL02_001080	COG1902	pentaerythritol trinitrate reductase activity
AKL02_001085	COG0583	DNA-binding transcription factor activity
AKL02_001100	COG1546	Belongs to the CinA family
AKL02_001100	COG1058	Belongs to the CinA family
AKL02_001105	COG0024	Methionine aminopeptidase
AKL02_001110	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AKL02_001115	COG0742	ribosomal rna small subunit methyltransferase
AKL02_001125	COG0678	peroxiredoxin activity
AKL02_001130	COG2154	pterin-4-alpha-carbinolamine dehydratase
AKL02_001135	COG0668	transmembrane transport
AKL02_001165	COG1346	cytolysis
AKL02_001170	COG2860	membrane
AKL02_001175	COG0328	RNA-DNA hybrid ribonuclease activity
AKL02_001190	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
AKL02_001195	COG1238	metal cluster binding
AKL02_001205	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
AKL02_001210	COG1758	RNA polymerase activity
AKL02_001215	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
AKL02_001235	COG4191	Histidine kinase
AKL02_001250	COG0559	Belongs to the binding-protein-dependent transport system permease family
AKL02_001275	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
AKL02_001285	COG0257	Belongs to the bacterial ribosomal protein bL36 family
AKL02_001300	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
AKL02_001315	COG0284	orotidine-5'-phosphate decarboxylase activity
AKL02_001345	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
AKL02_001350	COG0242	peptide deformylase activity
AKL02_001355	COG0242	peptide deformylase activity
AKL02_001360	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
AKL02_001395	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
AKL02_001400	COG0347	Belongs to the P(II) protein family
AKL02_001405	COG0004	ammonium transporteR
AKL02_001410	COG2814	Major facilitator Superfamily
AKL02_001415	COG1566	PFAM secretion protein HlyD family protein
AKL02_001430	COG2897	thiosulfate sulfurtransferase activity
AKL02_001450	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
AKL02_001455	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
AKL02_001525	COG4974	Belongs to the 'phage' integrase family
AKL02_001565	COG3306	glycosyltransferase involved in LPS biosynthesis
AKL02_001595	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
AKL02_001640	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
AKL02_001650	COG4548	von Willebrand factor, type A
AKL02_001655	COG0513	Belongs to the DEAD box helicase family
AKL02_001665	COG1070	Carbohydrate kinase
AKL02_001670	COG2017	converts alpha-aldose to the beta-anomer
AKL02_001680	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
AKL02_001695	COG3257	ureidoglycine aminohydrolase activity
AKL02_001700	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
AKL02_001710	COG0583	DNA-binding transcription factor activity
AKL02_001715	COG1960	acyl-CoA dehydrogenase activity
AKL02_001770	COG2197	response regulator
AKL02_001785	COG3920	Histidine kinase
AKL02_001790	COG2391	methyltransferase activity
AKL02_001800	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AKL02_001820	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
AKL02_001825	COG0632	four-way junction helicase activity
AKL02_001830	COG2255	four-way junction helicase activity
AKL02_001840	COG3768	UPF0283 membrane protein
AKL02_001850	COG3191	aminopeptidase activity
AKL02_001865	COG1376	ErfK ybiS ycfS ynhG family protein
AKL02_001880	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AKL02_001900	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
AKL02_001915	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
AKL02_001950	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
AKL02_001955	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
AKL02_001970	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AKL02_001985	COG0254	rRNA binding
AKL02_001990	COG0335	large ribosomal subunit rRNA binding
AKL02_002000	COG0336	Belongs to the RNA methyltransferase TrmD family
AKL02_002010	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
AKL02_002015	COG0228	four-way junction DNA binding
AKL02_002030	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
AKL02_002035	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
AKL02_002050	COG2943	transferase activity, transferring hexosyl groups
AKL02_002065	COG2111	Na H antiporter
AKL02_002065	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
AKL02_002070	COG1006	Multisubunit Na H antiporter MnhC subunit
AKL02_002075	COG0651	ATP synthesis coupled electron transport
AKL02_002085	COG2212	antiporter activity
AKL02_002090	COG1320	monovalent cation:proton antiporter activity
AKL02_002105	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
AKL02_002105	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AKL02_002110	COG0697	spore germination
AKL02_002115	COG0741	lytic transglycosylase activity
AKL02_002120	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AKL02_002130	COG4957	zinc ion binding
AKL02_002170	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
AKL02_002180	COG4786	Flagellar basal body rod
AKL02_002185	COG4786	Flagellar basal body rod
AKL02_002210	COG0745	RESPONSE REGULATOR receiver
AKL02_002215	COG1706	bacterial-type flagellum-dependent cell motility
AKL02_002230	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
AKL02_002240	COG5443	negative regulation of bacterial-type flagellum assembly
AKL02_002250	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
AKL02_002255	COG1338	Plays a role in the flagellum-specific transport system
AKL02_002260	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
AKL02_002270	COG1766	The M ring may be actively involved in energy transduction
AKL02_002295	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
AKL02_002305	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
AKL02_002315	COG1987	bacterial-type flagellum assembly
AKL02_002320	COG1677	Flagellar hook-basal body complex protein FliE
AKL02_002325	COG1558	bacterial-type flagellum-dependent cell motility
AKL02_002330	COG1815	bacterial-type flagellum-dependent cell motility
AKL02_002355	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
AKL02_002365	COG3152	Membrane
AKL02_002370	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
AKL02_002380	COG0824	Thioesterase
AKL02_002400	COG0823	Involved in the tonB-independent uptake of proteins
AKL02_002405	COG2885	chlorophyll binding
AKL02_002415	COG0037	tRNA processing
AKL02_002420	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
AKL02_002425	COG4106	trans-aconitate 2-methyltransferase activity
AKL02_002435	COG2759	Belongs to the formate--tetrahydrofolate ligase family
AKL02_002440	COG1605	Chorismate mutase
AKL02_002440	COG0077	Prephenate dehydratase
AKL02_002445	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
AKL02_002450	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
AKL02_002505	COG4964	Belongs to the GSP D family
AKL02_002525	COG0741	lytic transglycosylase activity
AKL02_002525	COG1196	nuclear chromosome segregation
AKL02_002525	COG0739	heme binding
AKL02_002540	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
AKL02_002540	COG1754	DNA topoisomerase type I activity
AKL02_002545	COG0758	DNA mediated transformation
AKL02_002550	COG0312	modulator of DNA gyrase
AKL02_002570	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
AKL02_002590	COG0612	Peptidase, M16
AKL02_002600	COG0277	FAD linked oxidase domain protein
AKL02_002610	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
AKL02_002615	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
AKL02_002620	COG0697	spore germination
AKL02_002645	COG1519	Transferase
AKL02_002655	COG0527	aspartate kinase activity
AKL02_002660	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
AKL02_002665	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AKL02_002670	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AKL02_002680	COG4175	Glycine betaine
AKL02_002680	COG3448	diguanylate cyclase activity
AKL02_002705	COG1846	Transcriptional regulator
AKL02_002710	COG0456	acetyltransferase
AKL02_002715	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
AKL02_002720	COG1917	Cupin 2, conserved barrel domain protein
AKL02_002725	COG0527	aspartate kinase activity
AKL02_002730	COG1271	oxidase subunit
AKL02_002735	COG1294	oxidase, subunit
AKL02_002745	COG2814	Major facilitator Superfamily
AKL02_002750	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AKL02_002755	COG0200	Binds to the 23S rRNA
AKL02_002760	COG0201	protein transport
AKL02_002765	COG0563	adenylate kinase activity
AKL02_002770	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
AKL02_002780	COG0202	RNA polymerase activity
AKL02_002785	COG0203	ribosomal protein L17
AKL02_002800	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
AKL02_002805	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
AKL02_002810	COG0564	pseudouridine synthase activity
AKL02_002815	COG0546	phosphoglycolate phosphatase activity
AKL02_002825	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AKL02_002830	COG4597	amino acid ABC transporter
AKL02_002835	COG0765	amino acid transport
AKL02_002840	COG1126	abc transporter atp-binding protein
AKL02_002845	COG0039	L-malate dehydrogenase activity
AKL02_002860	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
AKL02_002865	COG1028	Short-chain dehydrogenase reductase Sdr
AKL02_002870	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
AKL02_002890	COG1573	uracil-dna glycosylase
AKL02_002910	COG1678	Uncharacterized ACR, COG1678
AKL02_002915	COG0009	L-threonylcarbamoyladenylate synthase
AKL02_002920	COG1960	acyl-CoA dehydrogenase activity
AKL02_002935	COG0675	Transposase, IS605 OrfB family
AKL02_002960	COG3180	Ammonia monooxygenase
AKL02_002965	COG2358	TRAP transporter, solute receptor (TAXI family
AKL02_002980	COG4191	Histidine kinase
AKL02_003080	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
AKL02_003090	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
AKL02_003095	COG5328	Belongs to the UPF0262 family
AKL02_003105	COG1733	regulation of RNA biosynthetic process
AKL02_003110	COG0702	epimerase
AKL02_003140	COG3153	acetyltransferase
AKL02_003140	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
AKL02_003145	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
AKL02_003150	COG0424	maF-like protein
AKL02_003155	COG1530	ribonuclease E activity
AKL02_003160	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
AKL02_003175	COG1309	transcriptional regulator
AKL02_003215	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
AKL02_003240	COG1091	dTDP-4-dehydrorhamnose reductase activity
AKL02_003330	COG0765	amino acid transport
AKL02_003335	COG0765	amino acid transport
AKL02_003350	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
AKL02_003355	COG1960	acyl-CoA dehydrogenase activity
AKL02_003370	COG2986	histidine ammonia-lyase
AKL02_003375	COG1228	amidohydrolase
AKL02_003415	COG3609	addiction module antidote protein, CC2985 family
AKL02_003425	COG3012	SEC-C Motif Domain Protein
AKL02_003465	COG0583	DNA-binding transcription factor activity
AKL02_003470	COG2814	Major facilitator Superfamily
AKL02_003480	COG0789	Transcriptional regulator
AKL02_003550	COG1278	Cold shock
AKL02_003560	COG1278	Cold shock
AKL02_003575	COG4191	Histidine kinase
AKL02_003575	COG0784	Response regulator, receiver
AKL02_003590	COG4529	Protein conserved in bacteria
AKL02_003600	COG1879	ABC-type sugar transport system periplasmic component
AKL02_003605	COG1129	ABC transporter
AKL02_003610	COG1172	Belongs to the binding-protein-dependent transport system permease family
AKL02_003615	COG1028	Short-chain dehydrogenase reductase Sdr
AKL02_003625	COG3246	L-lysine catabolic process to acetate
AKL02_003630	COG3386	PFAM SMP-30 Gluconolaconase
AKL02_003635	COG0129	dihydroxy-acid dehydratase activity
AKL02_003640	COG2084	Dehydrogenase
AKL02_003645	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AKL02_003650	COG0277	FAD linked oxidase domain protein
AKL02_003655	COG2186	Transcriptional regulator
AKL02_003665	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
AKL02_003670	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
AKL02_003675	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
AKL02_003680	COG1028	Short-chain dehydrogenase reductase Sdr
AKL02_003705	COG1904	glucuronate isomerase
AKL02_003710	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
AKL02_003730	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
AKL02_003735	COG1028	Short-chain dehydrogenase reductase Sdr
AKL02_003740	COG0246	Mannitol dehydrogenase
AKL02_003745	COG1312	Catalyzes the dehydration of D-mannonate
AKL02_003750	COG2721	sulfolactate sulfo-lyase activity
AKL02_003755	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AKL02_003795	COG1028	Short-chain dehydrogenase reductase Sdr
AKL02_003805	COG0514	ATP-dependent DNA helicase (RecQ)
AKL02_003855	COG4974	Belongs to the 'phage' integrase family
AKL02_003870	COG0471	metal ion transport
AKL02_003870	COG3273	potassium ion transport
AKL02_003875	COG0673	inositol 2-dehydrogenase activity
AKL02_003885	COG0673	inositol 2-dehydrogenase activity
AKL02_003900	COG0395	ABC-type sugar transport system, permease component
AKL02_003905	COG1175	transmembrane transport
AKL02_003910	COG1653	transport
AKL02_003915	COG1609	Transcriptional regulator
AKL02_003925	COG0673	inositol 2-dehydrogenase activity
AKL02_003930	COG2188	Transcriptional regulator
AKL02_003940	COG4989	oxidoreductase activity
AKL02_003960	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
AKL02_003970	COG1172	Belongs to the binding-protein-dependent transport system permease family
AKL02_003975	COG1129	ABC transporter
AKL02_003980	COG1879	ABC-type sugar transport system periplasmic component
AKL02_003985	COG1984	allophanate hydrolase subunit 2
AKL02_004000	COG0511	ligase activity, forming carbon-carbon bonds
AKL02_004005	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
AKL02_004010	COG0583	DNA-binding transcription factor activity
AKL02_004015	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
AKL02_004020	COG1063	alcohol dehydrogenase
AKL02_004030	COG3284	Transcriptional regulator
AKL02_004040	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
AKL02_004060	COG0589	response to stress
AKL02_004070	COG0697	spore germination
AKL02_004100	COG2207	Transcriptional regulator
AKL02_004125	COG1017	nitric oxide dioxygenase activity
AKL02_004125	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
AKL02_004130	COG3228	Belongs to the MtfA family
AKL02_004135	COG3811	Belongs to the UPF0386 family
AKL02_004145	COG1063	alcohol dehydrogenase
AKL02_004150	COG1028	Short-chain dehydrogenase reductase Sdr
AKL02_004150	COG0604	alcohol dehydrogenase
AKL02_004150	COG3321	synthase
AKL02_004210	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AKL02_004215	COG0747	negative chemotaxis
AKL02_004225	COG4172	Belongs to the ABC transporter superfamily
AKL02_004235	COG0174	glutamine synthetase
AKL02_004245	COG3842	ATPase activity
AKL02_004250	COG1176	ABC-type spermidine putrescine transport system, permease component I
AKL02_004255	COG1177	transmembrane transport
AKL02_004275	COG1175	transmembrane transport
AKL02_004280	COG0395	ABC-type sugar transport system, permease component
AKL02_004295	COG2084	Dehydrogenase
AKL02_004300	COG0235	Class ii aldolase
AKL02_004305	COG3395	kinase activity
AKL02_004310	COG2084	Dehydrogenase
AKL02_004315	COG3622	Belongs to the hyi family
AKL02_004320	COG0667	Aldo Keto reductase
AKL02_004330	COG1172	Belongs to the binding-protein-dependent transport system permease family
AKL02_004340	COG1129	ABC transporter
AKL02_004345	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AKL02_004350	COG1609	Transcriptional regulator
AKL02_004355	COG1028	Short-chain dehydrogenase reductase Sdr
AKL02_004385	COG1175	transmembrane transport
AKL02_004395	COG3842	ATPase activity
AKL02_004415	COG2084	Dehydrogenase
AKL02_004425	COG1473	amidohydrolase
AKL02_004425	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
AKL02_004430	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
AKL02_004435	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
AKL02_004440	COG1595	DNA-templated transcription, initiation
AKL02_004455	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
AKL02_004465	COG4948	Mandelate Racemase Muconate Lactonizing
AKL02_004480	COG1414	Transcriptional regulator
AKL02_004485	COG1653	transport
AKL02_004490	COG1175	transmembrane transport
AKL02_004495	COG0395	ABC-type sugar transport system, permease component
AKL02_004510	COG0800	Aldolase
AKL02_004515	COG3386	PFAM SMP-30 Gluconolaconase
AKL02_004530	COG3842	ATPase activity
AKL02_004535	COG0395	ABC-type sugar transport system, permease component
AKL02_004540	COG1175	transmembrane transport
AKL02_004550	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
AKL02_004555	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AKL02_004560	COG0022	dehydrogenase e1 component
AKL02_004560	COG0508	dehydrogenase complex catalyzes the overall conversion of
AKL02_004565	COG0508	dehydrogenase complex catalyzes the overall conversion of
AKL02_004570	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
AKL02_004580	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
AKL02_004615	COG1741	Belongs to the pirin family
AKL02_004620	COG0655	NAD(P)H dehydrogenase (quinone) activity
AKL02_004655	COG0395	ABC-type sugar transport system, permease component
AKL02_004675	COG1737	Transcriptional regulator
AKL02_004680	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
AKL02_004690	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
AKL02_004695	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
AKL02_004695	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
AKL02_004705	COG0356	it plays a direct role in the translocation of protons across the membrane
AKL02_004720	COG0355	proton-transporting ATP synthase activity, rotational mechanism
AKL02_004725	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
AKL02_004730	COG1028	Short-chain dehydrogenase reductase Sdr
AKL02_004735	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
AKL02_004750	COG2837	iron assimilation
AKL02_004765	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
AKL02_004775	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
AKL02_004790	COG0590	tRNA wobble adenosine to inosine editing
AKL02_004795	COG3108	Peptidase M15
AKL02_004820	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
AKL02_004855	COG1376	ErfK ybiS ycfS ynhG family protein
AKL02_004860	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
AKL02_004860	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
AKL02_004875	COG1609	Transcriptional regulator
AKL02_004885	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
AKL02_004900	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AKL02_004925	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
AKL02_004930	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
AKL02_004940	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
AKL02_004965	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
AKL02_004980	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
AKL02_004985	COG1529	Aldehyde oxidase and xanthine dehydrogenase
AKL02_004990	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
AKL02_004995	COG2080	2 iron, 2 sulfur cluster binding
AKL02_005010	COG0667	Aldo Keto reductase
AKL02_005015	COG0477	Major facilitator Superfamily
AKL02_005025	COG0601	transmembrane transport
AKL02_005030	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AKL02_005040	COG4608	Belongs to the ABC transporter superfamily
AKL02_005045	COG0737	Belongs to the 5'-nucleotidase family
AKL02_005055	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AKL02_005060	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AKL02_005070	COG0069	glutamate synthase activity
AKL02_005075	COG0028	Belongs to the TPP enzyme family
AKL02_005080	COG3001	Fructosamine kinase
AKL02_005090	COG0129	dihydroxy-acid dehydratase activity
AKL02_005095	COG1201	RNA secondary structure unwinding
AKL02_005120	COG0187	DNA topoisomerase II activity
AKL02_005130	COG0625	glutathione transferase activity
AKL02_005135	COG2326	polyphosphate kinase activity
AKL02_005145	COG3909	cytochrome
AKL02_005155	COG0534	Mate efflux family protein
AKL02_005160	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AKL02_005175	COG1802	Transcriptional regulator
AKL02_005185	COG0505	Belongs to the CarA family
AKL02_005190	COG1610	YqeY-like protein
AKL02_005215	COG3474	cytochrome
AKL02_005220	COG0321	lipoyl(octanoyl) transferase activity
AKL02_005255	COG3842	ATPase activity
AKL02_005275	COG1177	transmembrane transport
AKL02_005290	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
AKL02_005300	COG0193	aminoacyl-tRNA hydrolase activity
AKL02_005310	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
AKL02_005320	COG1304	FMN binding
AKL02_005330	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
AKL02_005340	COG0218	Necessary for normal cell division and for the maintenance of normal septation
AKL02_005350	COG0706	membrane insertase activity
AKL02_005355	COG3706	GGDEF domain
AKL02_005355	COG4251	negative regulation of phosphorylation
AKL02_005355	COG2203	Gaf domain
AKL02_005355	COG5001	Diguanylate cyclase
AKL02_005360	COG0037	tRNA processing
AKL02_005370	COG0594	ribonuclease P activity
AKL02_005380	COG5002	protein histidine kinase activity
AKL02_005425	COG1802	Transcriptional regulator
AKL02_005445	COG1703	isobutyryl-CoA mutase activity
AKL02_005455	COG1643	Atp-dependent helicase
AKL02_005460	COG1607	acyl-coa hydrolase
AKL02_005480	COG0508	dehydrogenase complex catalyzes the overall conversion of
AKL02_005490	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
AKL02_005525	COG2301	Belongs to the HpcH HpaI aldolase family
AKL02_005540	COG2030	dehydratase
AKL02_005580	COG1131	(ABC) transporter
AKL02_005600	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
AKL02_005600	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
AKL02_005615	COG3622	Belongs to the hyi family
AKL02_005625	COG0714	Associated with various cellular activities
AKL02_005655	COG1435	thymidine kinase activity
AKL02_005670	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AKL02_005690	COG3118	belongs to the thioredoxin family
AKL02_005715	COG3853	Toxic anion resistance protein (TelA)
AKL02_005725	COG1187	pseudouridine synthase activity
AKL02_005730	COG0590	tRNA wobble adenosine to inosine editing
AKL02_005750	COG0534	Mate efflux family protein
AKL02_005755	COG0174	glutamine synthetase
AKL02_005770	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AKL02_005785	COG2130	NADP-dependent
AKL02_005790	COG0140	phosphoribosyl-ATP diphosphatase activity
AKL02_005795	COG0107	imidazoleglycerol-phosphate synthase activity
AKL02_005815	COG1234	tRNA 3'-trailer cleavage
AKL02_005825	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AKL02_005830	COG0404	The glycine cleavage system catalyzes the degradation of glycine
AKL02_005835	COG0509	glycine decarboxylation via glycine cleavage system
AKL02_005840	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
AKL02_005840	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
AKL02_005845	COG1494	fructose-1,6-bisphosphatase
AKL02_005865	COG1309	transcriptional regulator
AKL02_005875	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
AKL02_005890	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
AKL02_005895	COG0131	Imidazoleglycerol-phosphate dehydratase
AKL02_005910	COG0151	Belongs to the GarS family
AKL02_005935	COG0552	protein localization to endoplasmic reticulum
AKL02_005945	COG2917	probably involved in intracellular septation
AKL02_005970	COG0402	S-adenosylhomocysteine deaminase activity
AKL02_005975	COG2239	Acts as a magnesium transporter
AKL02_005980	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
AKL02_006030	COG0330	HflC and HflK could
AKL02_006035	COG0330	HflC and HflK could
AKL02_006045	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
AKL02_006055	COG1760	l-serine dehydratase
AKL02_006060	COG0513	Belongs to the DEAD box helicase family
AKL02_006090	COG1473	amidohydrolase
AKL02_006100	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
AKL02_006110	COG0504	CTP synthase activity
AKL02_006135	COG1121	(ABC) transporter
AKL02_006140	COG1108	ABC-type Mn2 Zn2 transport systems permease components
AKL02_006150	COG0531	amino acid
AKL02_006165	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
AKL02_006185	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
AKL02_006200	COG0596	Alpha beta hydrolase
AKL02_006255	COG5265	(ABC) transporter
AKL02_006280	COG1160	GTP binding
AKL02_006290	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
AKL02_006305	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AKL02_006310	COG1116	anion transmembrane transporter activity
AKL02_006315	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
AKL02_006320	COG0737	Belongs to the 5'-nucleotidase family
AKL02_006325	COG2816	NAD+ diphosphatase activity
AKL02_006335	COG1605	Chorismate mutase
AKL02_006335	COG0077	Prephenate dehydratase
AKL02_006345	COG4166	transmembrane transport
AKL02_006350	COG4174	ABC transporter (Permease)
AKL02_006355	COG4239	(ABC) transporter, permease
AKL02_006360	COG4172	Belongs to the ABC transporter superfamily
AKL02_006375	COG0587	DNA-directed DNA polymerase activity
AKL02_006395	COG0653	protein targeting
AKL02_006415	COG1215	transferase activity, transferring glycosyl groups
AKL02_006440	COG0589	response to stress
AKL02_006450	COG2358	TRAP transporter, solute receptor (TAXI family
AKL02_006460	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
AKL02_006470	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AKL02_006475	COG1215	transferase activity, transferring glycosyl groups
AKL02_006490	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AKL02_006495	COG2351	hydroxyisourate hydrolase activity
AKL02_006505	COG0840	transmembrane signaling receptor activity
AKL02_006510	COG0740	serine-type endopeptidase activity
AKL02_006535	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
AKL02_006545	COG0439	Biotin carboxylase
AKL02_006550	COG0511	ligase activity, forming carbon-carbon bonds
AKL02_006555	COG0493	'glutamate synthase
AKL02_006570	COG1309	transcriptional regulator
AKL02_006575	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
AKL02_006590	COG1309	transcriptional regulator
AKL02_006610	COG1116	anion transmembrane transporter activity
AKL02_006615	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AKL02_006620	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AKL02_006695	COG3750	Belongs to the UPF0335 family
AKL02_006715	COG0811	peptide transport
AKL02_006720	COG0848	biopolymer transport protein
AKL02_006735	COG1473	amidohydrolase
AKL02_006740	COG0589	response to stress
AKL02_006765	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
AKL02_006770	COG2166	iron-sulfur cluster assembly
AKL02_006780	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
AKL02_006790	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
AKL02_006810	COG3119	arylsulfatase activity
AKL02_006815	COG0656	L-ascorbic acid biosynthetic process
AKL02_006820	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
AKL02_006870	COG5290	Psort location Cytoplasmic, score
AKL02_006885	COG0210	DNA helicase
AKL02_006890	COG1469	GTP cyclohydrolase I activity
AKL02_006905	COG0625	glutathione transferase activity
AKL02_006910	COG1764	response to oxidative stress
AKL02_006915	COG0232	Belongs to the dGTPase family. Type 2 subfamily
AKL02_006935	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
AKL02_006940	COG1914	H( )-stimulated, divalent metal cation uptake system
AKL02_006945	COG1321	iron dependent repressor
AKL02_006960	COG0489	protein tyrosine kinase activity
AKL02_006970	COG2001	Belongs to the MraZ family
AKL02_006975	COG0275	rRNA processing
AKL02_006990	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
AKL02_007000	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
AKL02_007080	COG2309	aminopeptidase activity
AKL02_007100	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
AKL02_007115	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
AKL02_007120	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
AKL02_007125	COG0546	phosphoglycolate phosphatase activity
AKL02_007140	COG2423	ornithine cyclodeaminase activity
AKL02_007145	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AKL02_007150	COG1960	acyl-CoA dehydrogenase activity
AKL02_007170	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
AKL02_007190	COG1024	Enoyl-CoA hydratase
AKL02_007200	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AKL02_007205	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AKL02_007220	COG3743	rRNA binding
AKL02_007220	COG0261	This protein binds to 23S rRNA in the presence of protein L20
AKL02_007255	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
AKL02_007275	COG0713	ATP synthesis coupled electron transport
AKL02_007310	COG0513	Belongs to the DEAD box helicase family
AKL02_007330	COG3620	sequence-specific DNA binding
AKL02_007330	COG0617	tRNA 3'-terminal CCA addition
AKL02_007330	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
AKL02_007335	COG0457	Tetratricopeptide repeat
AKL02_007340	COG0457	Tetratricopeptide repeat
AKL02_007345	COG1280	lysine exporter protein (LysE YggA)
AKL02_007370	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
AKL02_007375	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
AKL02_007400	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
AKL02_007405	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
AKL02_007440	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
AKL02_007490	COG3409	Peptidoglycan-binding domain 1 protein
AKL02_007490	COG3267	Type II secretory pathway component ExeA
AKL02_007510	COG2030	dehydratase
AKL02_007515	COG0196	riboflavin kinase activity
AKL02_007520	COG2983	Belongs to the UPF0260 family
AKL02_007540	COG0492	ferredoxin-NADP+ reductase activity
AKL02_007545	COG1522	sequence-specific DNA binding
AKL02_007550	COG2814	Major facilitator Superfamily
AKL02_007570	COG0659	secondary active sulfate transmembrane transporter activity
AKL02_007585	COG5012	cobalamin binding
AKL02_007605	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
AKL02_007610	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
AKL02_007615	COG0047	phosphoribosylformylglycinamidine synthase activity
AKL02_007630	COG1530	ribonuclease E activity
AKL02_007645	COG0425	Belongs to the sulfur carrier protein TusA family
AKL02_007650	COG0785	Cytochrome C biogenesis protein
AKL02_007670	COG4221	oxidoreductase activity
AKL02_007675	COG0563	adenylate kinase activity
AKL02_007680	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
AKL02_007685	COG0149	triose-phosphate isomerase activity
AKL02_007705	COG1902	pentaerythritol trinitrate reductase activity
AKL02_007710	COG2151	metal-sulfur cluster biosynthetic enzyme
AKL02_007715	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
AKL02_007720	COG2890	protein-(glutamine-N5) methyltransferase activity
AKL02_007735	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
AKL02_007740	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
AKL02_007745	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
AKL02_007750	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
AKL02_007765	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
AKL02_007785	COG1272	protein, Hemolysin III
AKL02_007800	COG0175	sulfate reduction
AKL02_007805	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
AKL02_007815	COG1648	precorrin-2 dehydrogenase activity
AKL02_007815	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
AKL02_007820	COG1522	sequence-specific DNA binding
AKL02_007830	COG4191	Histidine kinase
AKL02_007840	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
AKL02_007845	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
AKL02_007850	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
AKL02_007860	COG0739	heme binding
AKL02_007865	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
AKL02_007875	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
AKL02_007880	COG2814	Major facilitator Superfamily
AKL02_007890	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AKL02_007895	COG0501	Belongs to the peptidase M48B family
AKL02_007980	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AKL02_007990	COG0459	protein refolding
AKL02_008005	COG1227	inorganic diphosphatase activity
AKL02_008020	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AKL02_008030	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
AKL02_008035	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
AKL02_008040	COG1845	cytochrome c oxidase, subunit III
AKL02_008065	COG3108	Peptidase M15
AKL02_008080	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AKL02_008085	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
AKL02_008100	COG0433	COG0433 Predicted ATPase
AKL02_008115	COG0583	DNA-binding transcription factor activity
AKL02_008125	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
AKL02_008140	COG0463	Glycosyl transferase, family 2
AKL02_008140	COG1216	Glycosyl transferase, family 2
AKL02_008190	COG4251	negative regulation of phosphorylation
AKL02_008210	COG1414	Transcriptional regulator
AKL02_008215	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
AKL02_008220	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
AKL02_008230	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
AKL02_008265	COG4569	acetaldehyde dehydrogenase (acetylating) activity
AKL02_008270	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AKL02_008280	COG0583	DNA-binding transcription factor activity
AKL02_008295	COG3485	protocatechuate 3,4-dioxygenase
AKL02_008310	COG0196	riboflavin kinase activity
AKL02_008325	COG0642	Histidine kinase
AKL02_008350	COG1028	Short-chain dehydrogenase reductase Sdr
AKL02_008355	COG0318	PFAM AMP-dependent synthetase and ligase
AKL02_008395	COG0028	Belongs to the TPP enzyme family
AKL02_008410	COG0577	efflux transmembrane transporter activity
AKL02_008410	COG1136	(ABC) transporter
AKL02_008445	COG4989	oxidoreductase activity
AKL02_008455	COG0701	Predicted permease
AKL02_008460	COG0640	Transcriptional regulator
AKL02_008465	COG1028	Short-chain dehydrogenase reductase Sdr
AKL02_008475	COG0385	Bile acid
AKL02_008480	COG2072	flavoprotein involved in K transport
AKL02_008495	COG1994	Peptidase M50
AKL02_008495	COG0517	IMP dehydrogenase activity
AKL02_008500	COG1024	Enoyl-CoA hydratase
AKL02_008505	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
AKL02_008510	COG1309	transcriptional regulator
AKL02_008520	COG0123	including yeast histone deacetylase and acetoin utilization protein
AKL02_008530	COG0318	PFAM AMP-dependent synthetase and ligase
AKL02_008535	COG0477	Major facilitator Superfamily
AKL02_008560	COG0583	DNA-binding transcription factor activity
AKL02_008570	COG4221	oxidoreductase activity
AKL02_008575	COG1012	belongs to the aldehyde dehydrogenase family
AKL02_008585	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AKL02_008590	COG1732	Glycine betaine
AKL02_008595	COG1174	glycine betaine transport
AKL02_008600	COG1125	glycine betaine transport
AKL02_008605	COG1174	glycine betaine transport
AKL02_008610	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AKL02_008615	COG0765	amino acid transport
AKL02_008620	COG1126	abc transporter atp-binding protein
AKL02_008625	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
AKL02_008630	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
AKL02_008635	COG1780	Probably involved in ribonucleotide reductase function
AKL02_008645	COG0646	methionine synthase
AKL02_008645	COG1410	methionine synthase
AKL02_008655	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
AKL02_008655	COG0574	Belongs to the PEP-utilizing enzyme family
AKL02_008660	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
AKL02_008665	COG1268	BioY protein
AKL02_008680	COG0602	queuosine metabolic process
AKL02_008685	COG0720	synthase
AKL02_008690	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
AKL02_008695	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
AKL02_008700	COG0352	thiamine-phosphate diphosphorylase activity
AKL02_008705	COG0351	phosphomethylpyrimidine kinase
AKL02_008710	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
AKL02_008720	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
AKL02_008765	COG2132	Multicopper oxidase
AKL02_008785	COG0277	FAD linked oxidase domain protein
AKL02_008800	COG2814	Major facilitator Superfamily
AKL02_008850	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
AKL02_008925	COG4806	L-rhamnose isomerase
AKL02_008930	COG1028	Short-chain dehydrogenase reductase Sdr
AKL02_008930	COG3347	Dehydrogenase
AKL02_008945	COG1129	ABC transporter
AKL02_008950	COG1172	Belongs to the binding-protein-dependent transport system permease family
AKL02_008960	COG3254	rhamnose metabolic process
AKL02_008975	COG1073	alpha beta
AKL02_008980	COG0583	DNA-binding transcription factor activity
AKL02_008985	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
AKL02_009005	COG3002	Belongs to the UPF0753 family
AKL02_009010	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
AKL02_009020	COG0508	dehydrogenase complex catalyzes the overall conversion of
AKL02_009030	COG0508	dehydrogenase complex catalyzes the overall conversion of
AKL02_009030	COG0022	dehydrogenase e1 component
AKL02_009035	COG0022	dehydrogenase e1 component
AKL02_009040	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
AKL02_009060	COG1879	ABC-type sugar transport system periplasmic component
AKL02_009070	COG1172	Belongs to the binding-protein-dependent transport system permease family
AKL02_009075	COG1172	Belongs to the binding-protein-dependent transport system permease family
AKL02_009080	COG1129	ABC transporter
AKL02_009085	COG2084	Dehydrogenase
AKL02_009105	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
AKL02_009185	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AKL02_009195	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
AKL02_009200	COG0776	regulation of translation
AKL02_009210	COG0662	Cupin 2, conserved barrel domain protein
AKL02_009220	COG1741	Belongs to the pirin family
AKL02_009240	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
AKL02_009275	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
AKL02_009280	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
AKL02_009300	COG0148	phosphopyruvate hydratase activity
AKL02_009305	COG0697	spore germination
AKL02_009315	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
AKL02_009320	COG0628	permease
AKL02_009365	COG1028	Short-chain dehydrogenase reductase Sdr
AKL02_009430	COG0745	RESPONSE REGULATOR receiver
AKL02_009460	COG1028	Short-chain dehydrogenase reductase Sdr
AKL02_009470	COG1116	anion transmembrane transporter activity
AKL02_009510	COG0747	negative chemotaxis
AKL02_009520	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AKL02_009540	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
AKL02_009555	COG1366	Belongs to the anti-sigma-factor antagonist family
AKL02_009560	COG1366	Belongs to the anti-sigma-factor antagonist family
AKL02_009600	COG2326	polyphosphate kinase activity
AKL02_009610	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
AKL02_009645	COG0517	IMP dehydrogenase activity
AKL02_009645	COG0516	GMP reductase activity
AKL02_009655	COG0494	nUDIX hydrolase
AKL02_009665	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
AKL02_009665	COG3264	Mechanosensitive ion channel
AKL02_009670	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
AKL02_009675	COG0114	fumarate hydratase activity
AKL02_009720	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
AKL02_009725	COG0415	Belongs to the DNA photolyase family
AKL02_009735	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
AKL02_009735	COG0662	Cupin 2, conserved barrel domain protein
AKL02_009740	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
AKL02_009755	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
AKL02_009765	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
AKL02_009800	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
AKL02_009800	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
AKL02_009820	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
AKL02_009830	COG0215	cysteine-tRNA ligase activity
AKL02_009835	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AKL02_009845	COG0840	transmembrane signaling receptor activity
AKL02_009850	COG2201	protein-glutamate methylesterase activity
AKL02_009855	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
AKL02_009870	COG0745	RESPONSE REGULATOR receiver
AKL02_009875	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
AKL02_009880	COG0835	chemotaxis
AKL02_009890	COG0745	RESPONSE REGULATOR receiver
AKL02_009900	COG0837	glucose binding
AKL02_009905	COG2723	6-phospho-beta-galactosidase activity
AKL02_009910	COG1609	Transcriptional regulator
AKL02_009915	COG1653	transport
AKL02_009920	COG1175	transmembrane transport
AKL02_009925	COG0395	ABC-type sugar transport system, permease component
AKL02_009930	COG0366	Alpha amylase catalytic
AKL02_009935	COG3842	ATPase activity
AKL02_009950	COG0519	Catalyzes the synthesis of GMP from XMP
AKL02_009950	COG0518	GMP synthase (glutamine-hydrolyzing) activity
AKL02_009955	COG4536	flavin adenine dinucleotide binding
AKL02_009960	COG4974	Belongs to the 'phage' integrase family
AKL02_009975	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
AKL02_009980	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
AKL02_010015	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
AKL02_010075	COG1196	nuclear chromosome segregation
AKL02_010095	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
AKL02_010100	COG0730	response to heat
AKL02_010105	COG3956	TIGRFAM MazG family protein
AKL02_010110	COG1473	amidohydrolase
AKL02_010115	COG1862	Preprotein translocase
AKL02_010120	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
AKL02_010125	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
AKL02_010130	COG3737	Protein of unknown function (DUF498/DUF598)
AKL02_010135	COG4133	protoheme IX ABC transporter activity
AKL02_010140	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
AKL02_010145	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
AKL02_010155	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AKL02_010160	COG0629	single-stranded DNA binding
AKL02_010180	COG0741	lytic transglycosylase activity
AKL02_010180	COG0739	heme binding
AKL02_010180	COG1196	nuclear chromosome segregation
AKL02_010200	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
AKL02_010210	COG2814	Major facilitator Superfamily
AKL02_010235	COG4166	transmembrane transport
AKL02_010240	COG1028	Short-chain dehydrogenase reductase Sdr
AKL02_010260	COG4618	COG4618 ABC-type protease lipase transport system, ATPase and permease components
AKL02_010275	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AKL02_010285	COG2084	Dehydrogenase
AKL02_010295	COG0671	phosphoesterase, PA-phosphatase related
AKL02_010300	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
AKL02_010300	COG0392	lysyltransferase activity
AKL02_010305	COG0366	Alpha amylase catalytic
AKL02_010310	COG0058	SHG alpha-glucan phosphorylase activity
AKL02_010315	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
AKL02_010325	COG0297	glycogen (starch) synthase activity
AKL02_010335	COG0033	Phosphoglucomutase
AKL02_010350	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
AKL02_010375	COG1850	ribulose-bisphosphate carboxylase activity
AKL02_010440	COG2771	luxR family
AKL02_010445	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
AKL02_010450	COG0052	Belongs to the universal ribosomal protein uS2 family
AKL02_010455	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
AKL02_010460	COG1923	regulation of RNA biosynthetic process
AKL02_010465	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
AKL02_010470	COG0569	domain protein
AKL02_010475	COG3842	ATPase activity
AKL02_010480	COG1177	transmembrane transport
AKL02_010490	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AKL02_010515	COG2321	neutral zinc metallopeptidase
AKL02_010520	COG1238	metal cluster binding
AKL02_010535	COG2313	pseudouridylate synthase activity
AKL02_010550	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
AKL02_010565	COG0719	Fe-S assembly protein
AKL02_010570	COG0396	ATPase activity
AKL02_010575	COG0393	Putative heavy-metal-binding
AKL02_010585	COG0719	Fe-S assembly protein
AKL02_010590	COG1104	cysteine desulfurase activity
AKL02_010595	COG1959	2 iron, 2 sulfur cluster binding
AKL02_010600	COG2945	thiolester hydrolase activity
AKL02_010625	COG0538	isocitrate dehydrogenase activity
AKL02_010645	COG2076	Multidrug Resistance protein
AKL02_010650	COG1217	gtp-binding protein TYPA
AKL02_010655	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
AKL02_010660	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
AKL02_010680	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AKL02_010695	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
AKL02_010700	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
AKL02_010705	COG0745	RESPONSE REGULATOR receiver
AKL02_010715	COG0482	sulfurtransferase activity
AKL02_010730	COG1793	dna ligase
AKL02_010745	COG1522	sequence-specific DNA binding
AKL02_010750	COG1012	belongs to the aldehyde dehydrogenase family
AKL02_010755	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
AKL02_010765	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AKL02_010770	COG3494	Protein of unknown function (DUF1009)
AKL02_010775	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AKL02_010815	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
AKL02_010820	COG0233	cytoplasmic translational termination
AKL02_010840	COG1012	belongs to the aldehyde dehydrogenase family
AKL02_010865	COG3842	ATPase activity
AKL02_010875	COG1176	ABC-type spermidine putrescine transport system, permease component I
AKL02_010895	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
AKL02_010900	COG0248	Ppx GppA phosphatase
AKL02_010905	COG5002	protein histidine kinase activity
AKL02_010920	COG0194	GDP metabolic process
AKL02_010925	COG1561	YicC-like family, N-terminal region
AKL02_010970	COG2204	response regulator
AKL02_010980	COG2204	response regulator
AKL02_010985	COG3852	Histidine kinase
AKL02_010990	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
AKL02_010995	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
AKL02_010995	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
AKL02_011000	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
AKL02_011005	COG1058	Belongs to the CinA family
AKL02_011005	COG1546	Belongs to the CinA family
AKL02_011010	COG0004	ammonium transporteR
AKL02_011015	COG2867	negative regulation of translational initiation
AKL02_011020	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
AKL02_011030	COG4214	carbohydrate transport
AKL02_011035	COG0559	Belongs to the binding-protein-dependent transport system permease family
AKL02_011055	COG0583	DNA-binding transcription factor activity
AKL02_011070	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
AKL02_011075	COG0646	methionine synthase
AKL02_011075	COG1410	methionine synthase
AKL02_011120	COG1072	(Pantothenic acid kinase))
AKL02_011125	COG0352	thiamine-phosphate diphosphorylase activity
AKL02_011130	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
AKL02_011140	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
AKL02_011145	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
AKL02_011180	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
AKL02_011185	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
AKL02_011190	COG2514	catechol 2,3-dioxygenase activity
AKL02_011195	COG2259	Doxx family
AKL02_011200	COG0583	DNA-binding transcription factor activity
AKL02_011220	COG0133	tryptophan synthase activity
AKL02_011225	COG0135	phosphoribosylanthranilate isomerase activity
AKL02_011235	COG0776	regulation of translation
AKL02_011240	COG0539	negative regulation of cytoplasmic translation
AKL02_011245	COG0386	Belongs to the glutathione peroxidase family
AKL02_011270	COG0220	tRNA (guanine-N7-)-methyltransferase activity
AKL02_011280	COG2259	Doxx family
AKL02_011285	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
AKL02_011295	COG0815	Transfers the fatty acyl group on membrane lipoproteins
AKL02_011305	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
AKL02_011315	COG0564	pseudouridine synthase activity
AKL02_011340	COG2116	formate transmembrane transporter activity
AKL02_011350	COG1573	uracil-dna glycosylase
AKL02_011370	COG0179	Fumarylacetoacetate (FAA) hydrolase
AKL02_011395	COG3258	Cytochrome c
AKL02_011400	COG0725	ABC transporter, periplasmic molybdate-binding protein
AKL02_011405	COG4149	molybdate abc transporter
AKL02_011410	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
AKL02_011415	COG0506	proline dehydrogenase activity
AKL02_011415	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
AKL02_011415	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
AKL02_011425	COG0737	Belongs to the 5'-nucleotidase family
AKL02_011435	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
AKL02_011445	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
AKL02_011455	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
AKL02_011465	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AKL02_011470	COG1024	Enoyl-CoA hydratase
AKL02_011475	COG4608	Belongs to the ABC transporter superfamily
AKL02_011480	COG0444	Belongs to the ABC transporter superfamily
AKL02_011485	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AKL02_011490	COG0601	transmembrane transport
AKL02_011505	COG2307	Protein conserved in bacteria
AKL02_011505	COG2308	Evidence 4 Homologs of previously reported genes of
AKL02_011515	COG1840	ABC-type Fe3 transport system, periplasmic component
AKL02_011525	COG1957	nucleoside hydrolase
AKL02_011545	COG3588	fructose-bisphosphate aldolase
AKL02_011555	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
AKL02_011560	COG0508	dehydrogenase complex catalyzes the overall conversion of
AKL02_011560	COG0022	dehydrogenase e1 component
AKL02_011565	COG0508	dehydrogenase complex catalyzes the overall conversion of
AKL02_011660	COG4695	Portal protein
AKL02_011675	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
AKL02_011680	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
AKL02_011695	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
AKL02_011705	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
AKL02_011730	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
AKL02_011730	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
AKL02_011735	COG4618	COG4618 ABC-type protease lipase transport system, ATPase and permease components
AKL02_011740	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AKL02_011770	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AKL02_011775	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AKL02_011795	COG0544	peptidyl-prolyl cis-trans isomerase activity
AKL02_011805	COG1295	ribonuclease BN
AKL02_011810	COG0359	binds to the 23S rRNA
AKL02_011815	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
AKL02_011820	COG0360	Binds together with S18 to 16S ribosomal RNA
AKL02_011845	COG1278	Cold shock
AKL02_011850	COG2267	carboxylic ester hydrolase activity
AKL02_011875	COG2391	methyltransferase activity
AKL02_011885	COG0069	glutamate synthase activity
AKL02_011895	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
AKL02_011900	COG4139	cobalamin transport
AKL02_011910	COG4206	TonB-dependent receptor
AKL02_011925	COG0010	Belongs to the arginase family
AKL02_011930	COG1275	C4-dicarboxylate transporter malic acid transport protein
AKL02_011935	COG1959	2 iron, 2 sulfur cluster binding
AKL02_011945	COG0105	UTP biosynthetic process
AKL02_011950	COG0488	(ABC) transporter
AKL02_011955	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
AKL02_011960	COG1612	heme a metabolic process
AKL02_011975	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
AKL02_012005	COG0418	dihydroorotase activity
AKL02_012010	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
AKL02_012015	COG0305	Participates in initiation and elongation during chromosome replication
AKL02_012020	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
AKL02_012025	COG0860	N-Acetylmuramoyl-L-alanine amidase
AKL02_012030	COG0436	Aminotransferase
AKL02_012055	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
AKL02_012065	COG0156	8-amino-7-oxononanoate synthase activity
AKL02_012085	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
AKL02_012100	COG0287	Prephenate dehydrogenase
AKL02_012105	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
AKL02_012110	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
AKL02_012115	COG4213	ABC transporter substrate-binding protein
AKL02_012155	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
AKL02_012170	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
AKL02_012185	COG4175	Glycine betaine
AKL02_012185	COG3448	diguanylate cyclase activity
AKL02_012190	COG4176	ABC-type proline glycine betaine transport system permease component
AKL02_012210	COG0395	ABC-type sugar transport system, permease component
AKL02_012215	COG1175	transmembrane transport
AKL02_012225	COG1609	Transcriptional regulator
AKL02_012230	COG3424	synthase
AKL02_012235	COG1755	Isoprenylcysteine carboxyl methyltransferase
AKL02_012250	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
AKL02_012260	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
AKL02_012265	COG3246	L-lysine catabolic process to acetate
AKL02_012270	COG3485	protocatechuate 3,4-dioxygenase
AKL02_012275	COG3485	protocatechuate 3,4-dioxygenase
AKL02_012280	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
AKL02_012285	COG2267	carboxylic ester hydrolase activity
AKL02_012290	COG0583	DNA-binding transcription factor activity
AKL02_012310	COG0583	DNA-binding transcription factor activity
AKL02_012315	COG4638	Rieske (2fe-2S)
AKL02_012325	COG0446	pyridine nucleotide-disulphide oxidoreductase
AKL02_012325	COG1902	pentaerythritol trinitrate reductase activity
AKL02_012335	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AKL02_012340	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
AKL02_012340	COG0662	Cupin 2, conserved barrel domain protein
AKL02_012360	COG1215	transferase activity, transferring glycosyl groups
AKL02_012365	COG3306	glycosyltransferase involved in LPS biosynthesis
AKL02_012420	COG1183	phosphatidylcholine synthase activity
AKL02_012425	COG0688	phosphatidylethanolamine metabolic process
AKL02_012440	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
AKL02_012445	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
AKL02_012455	COG1024	Enoyl-CoA hydratase
AKL02_012460	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
AKL02_012480	COG0211	Belongs to the bacterial ribosomal protein bL27 family
AKL02_012485	COG3743	rRNA binding
AKL02_012485	COG0261	This protein binds to 23S rRNA in the presence of protein L20
AKL02_012490	COG1804	L-carnitine dehydratase bile acid-inducible protein F
AKL02_012495	COG0488	(ABC) transporter
AKL02_012515	COG0333	Belongs to the bacterial ribosomal protein bL32 family
AKL02_012545	COG0717	Belongs to the dCTP deaminase family
AKL02_012550	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AKL02_012580	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
AKL02_012585	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
AKL02_012590	COG1472	Belongs to the glycosyl hydrolase 3 family
AKL02_012600	COG0018	arginyl-trna synthetase
AKL02_012610	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
AKL02_012620	COG0308	aminopeptidase N
AKL02_012630	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
AKL02_012635	COG2354	Protein conserved in bacteria
AKL02_012660	COG3243	poly(R)-hydroxyalkanoic acid synthase
AKL02_012675	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
AKL02_012680	COG1278	Cold shock
AKL02_012685	COG1393	Belongs to the ArsC family
AKL02_012690	COG1136	(ABC) transporter
AKL02_012705	COG0442	prolyl-tRNA aminoacylation
AKL02_012710	COG0628	permease
AKL02_012720	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
AKL02_012725	COG0248	Ppx GppA phosphatase
AKL02_012745	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
AKL02_012745	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
AKL02_012760	COG4770	biotin carboxylase activity
AKL02_012785	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
AKL02_012790	COG1396	sequence-specific DNA binding
AKL02_012790	COG3800	Transcriptional regulator
AKL02_012815	COG1012	belongs to the aldehyde dehydrogenase family
AKL02_012870	COG1047	Peptidyl-prolyl cis-trans
AKL02_012890	COG3273	potassium ion transport
AKL02_012890	COG0471	metal ion transport
AKL02_012895	COG1692	metallophosphoesterase
AKL02_012905	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
AKL02_012915	COG3185	4-Hydroxyphenylpyruvate dioxygenase
AKL02_012915	COG1082	Xylose isomerase domain protein TIM barrel
AKL02_012920	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
AKL02_012925	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
AKL02_012930	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
AKL02_012940	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
AKL02_012945	COG1802	Transcriptional regulator
AKL02_012955	COG1028	Short-chain dehydrogenase reductase Sdr
AKL02_012960	COG3485	protocatechuate 3,4-dioxygenase
AKL02_012965	COG1454	alcohol dehydrogenase
AKL02_012970	COG1129	ABC transporter
AKL02_013005	COG1063	alcohol dehydrogenase
AKL02_013020	COG1283	sodium-dependent phosphate transmembrane transporter activity
AKL02_013040	COG0811	peptide transport
AKL02_013050	COG1629	transport
AKL02_013060	COG4558	Periplasmic binding protein
AKL02_013065	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AKL02_013070	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
AKL02_013090	COG4221	oxidoreductase activity
AKL02_013100	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AKL02_013105	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
AKL02_013110	COG4521	taurine ABC transporter
AKL02_013115	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
AKL02_013120	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AKL02_013125	COG2133	pyrroloquinoline quinone binding
AKL02_013130	COG0484	heat shock protein binding
AKL02_013160	COG0006	proline dipeptidase activity
AKL02_013165	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
AKL02_013175	COG0277	FAD linked oxidase domain protein
AKL02_013185	COG0497	DNA recombination
AKL02_013190	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
AKL02_013200	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
AKL02_013205	COG0849	cell division
AKL02_013210	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
AKL02_013235	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
AKL02_013275	COG0656	L-ascorbic acid biosynthetic process
AKL02_013300	COG1309	transcriptional regulator
AKL02_013310	COG1131	(ABC) transporter
AKL02_013355	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AKL02_013365	COG4974	Belongs to the 'phage' integrase family
AKL02_013410	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
AKL02_013440	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
AKL02_013445	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
AKL02_013445	COG1618	nucleotide phosphatase activity, acting on free nucleotides
AKL02_013455	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
AKL02_013460	COG0129	dihydroxy-acid dehydratase activity
AKL02_013465	COG0800	Aldolase
AKL02_013490	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
AKL02_013495	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
AKL02_013500	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
AKL02_013515	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
AKL02_013530	COG0028	Belongs to the TPP enzyme family
AKL02_013535	COG0440	acetolactate synthase activity
AKL02_013560	COG1215	transferase activity, transferring glycosyl groups
AKL02_013590	COG2824	Alkylphosphonate utilization operon protein PhnA
AKL02_013605	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
AKL02_013620	COG1278	Cold shock
AKL02_013625	COG0259	pyridoxamine-phosphate oxidase activity
AKL02_013630	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
AKL02_013650	COG0436	Aminotransferase
AKL02_013660	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
AKL02_013675	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
AKL02_013680	COG0134	indole-3-glycerol-phosphate synthase activity
AKL02_013685	COG0315	cyclic pyranopterin monophosphate synthase activity
AKL02_013700	COG0658	competence protein
AKL02_013700	COG2333	competence protein COMEC
AKL02_013705	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AKL02_013710	COG0372	Belongs to the citrate synthase family
AKL02_013720	COG4221	oxidoreductase activity
AKL02_013725	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
AKL02_013730	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
AKL02_013740	COG1522	sequence-specific DNA binding
AKL02_013755	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AKL02_013765	COG0805	protein transport
AKL02_013775	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
AKL02_013785	COG2095	MarC family integral membrane protein
AKL02_013790	COG3577	Aspartyl protease
AKL02_013805	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
AKL02_013810	COG0737	Belongs to the 5'-nucleotidase family
AKL02_013815	COG3258	Cytochrome c
AKL02_013840	COG0785	Cytochrome C biogenesis protein
AKL02_013850	COG0640	Transcriptional regulator
AKL02_013875	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
AKL02_013880	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
AKL02_013900	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
AKL02_013920	COG1846	Transcriptional regulator
AKL02_013925	COG0745	RESPONSE REGULATOR receiver
AKL02_013930	COG0723	plastoquinol--plastocyanin reductase activity
AKL02_013945	COG2329	Antibiotic biosynthesis monooxygenase
AKL02_013960	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
AKL02_013985	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
AKL02_013990	COG1178	ABC-type Fe3 transport system permease component
AKL02_014010	COG0288	reversible hydration of carbon dioxide
AKL02_014020	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
AKL02_014025	COG0791	NLP P60 protein
AKL02_014030	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
AKL02_014060	COG3591	Belongs to the peptidase S1B family
AKL02_014065	COG3591	Belongs to the peptidase S1B family
AKL02_014070	COG0247	lactate metabolic process
AKL02_014075	COG0277	FAD linked oxidase domain protein
AKL02_014080	COG0277	FAD linked oxidase domain protein
AKL02_014090	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
AKL02_014110	COG1012	belongs to the aldehyde dehydrogenase family
AKL02_014115	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
AKL02_014120	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AKL02_014135	COG1172	Belongs to the binding-protein-dependent transport system permease family
AKL02_014145	COG1879	ABC-type sugar transport system periplasmic component
AKL02_014150	COG1349	DNA-binding transcription factor activity
AKL02_014160	COG2897	thiosulfate sulfurtransferase activity
AKL02_014165	COG2391	methyltransferase activity
AKL02_014180	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
AKL02_014185	COG2894	cell division
AKL02_014190	COG0850	regulation of cytokinetic process
AKL02_014215	COG0583	DNA-binding transcription factor activity
AKL02_014235	COG1063	alcohol dehydrogenase
AKL02_014325	COG1686	Belongs to the peptidase S11 family
AKL02_014330	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
AKL02_014340	COG0084	hydrolase, TatD family'
AKL02_014345	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
AKL02_014345	COG0321	lipoyl(octanoyl) transferase activity
AKL02_014360	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
AKL02_014370	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
AKL02_014405	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
AKL02_014420	COG1846	Transcriptional regulator
AKL02_014465	COG0411	ABC transporter
AKL02_014505	COG0804	urea catabolic process
AKL02_014510	COG0832	Belongs to the urease beta subunit family
AKL02_014520	COG0831	urea catabolic process
AKL02_014525	COG0829	nickel cation binding
AKL02_014530	COG1522	sequence-specific DNA binding
AKL02_014535	COG1522	sequence-specific DNA binding
AKL02_014555	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AKL02_014560	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
AKL02_014575	COG0574	Belongs to the PEP-utilizing enzyme family
AKL02_014575	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
AKL02_014580	COG0751	glycine-tRNA ligase activity
AKL02_014590	COG0752	glycyl-tRNA synthetase alpha subunit
AKL02_014600	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
AKL02_014605	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
AKL02_014625	COG0446	pyridine nucleotide-disulphide oxidoreductase
AKL02_014625	COG0404	The glycine cleavage system catalyzes the degradation of glycine
AKL02_014635	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AKL02_014645	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
AKL02_014655	COG3842	ATPase activity
AKL02_014660	COG0300	oxidoreductase activity
AKL02_014670	COG0483	inositol monophosphate 1-phosphatase activity
AKL02_014675	COG1396	sequence-specific DNA binding
AKL02_014680	COG0604	alcohol dehydrogenase
AKL02_014685	COG0583	DNA-binding transcription factor activity
AKL02_014695	COG0670	Belongs to the BI1 family
AKL02_014705	COG1305	Transglutaminase-like
AKL02_014710	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
AKL02_014715	COG0581	inorganic phosphate transmembrane transporter activity
AKL02_014720	COG0573	inorganic phosphate transmembrane transporter activity
AKL02_014725	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
AKL02_014730	COG3386	PFAM SMP-30 Gluconolaconase
AKL02_014745	COG0129	dihydroxy-acid dehydratase activity
AKL02_014755	COG4214	carbohydrate transport
AKL02_014785	COG1011	Hydrolase
AKL02_014790	COG3920	Histidine kinase
AKL02_014790	COG2202	Pas domain
AKL02_014835	COG1566	PFAM secretion protein HlyD family protein
AKL02_014840	COG0577	efflux transmembrane transporter activity
AKL02_014840	COG1136	(ABC) transporter
AKL02_014845	COG0577	efflux transmembrane transporter activity
AKL02_014845	COG1136	(ABC) transporter
AKL02_014860	COG0556	nucleotide-excision repair
AKL02_014900	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
AKL02_014905	COG2081	HI0933 family
AKL02_014960	COG0659	secondary active sulfate transmembrane transporter activity
AKL02_014965	COG0589	response to stress
AKL02_014995	COG0395	ABC-type sugar transport system, permease component
AKL02_015000	COG1454	alcohol dehydrogenase
AKL02_015005	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
AKL02_015020	COG0395	ABC-type sugar transport system, permease component
AKL02_015030	COG3842	ATPase activity
AKL02_015035	COG3842	ATPase activity
AKL02_015050	COG3347	Dehydrogenase
AKL02_015050	COG1028	Short-chain dehydrogenase reductase Sdr
AKL02_015075	COG2390	Transcriptional regulator
AKL02_015095	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
AKL02_015120	COG1162	GTPase activity
AKL02_015130	COG2197	response regulator
AKL02_015150	COG0697	spore germination
AKL02_015190	COG2855	membrane
AKL02_015195	COG0583	DNA-binding transcription factor activity
AKL02_015200	COG0784	Response regulator, receiver
AKL02_015210	COG3920	Histidine kinase
AKL02_015235	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
AKL02_015240	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
AKL02_015245	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
AKL02_015245	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
AKL02_015260	COG1596	polysaccharide export
AKL02_015270	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
AKL02_015270	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
AKL02_015275	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
AKL02_015280	COG0432	Pfam Uncharacterised protein family UPF0047
AKL02_015305	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
AKL02_015310	COG0358	DNA primase activity
AKL02_015340	COG3046	protein related to deoxyribodipyrimidine photolyase
AKL02_015355	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AKL02_015375	COG0768	penicillin binding
AKL02_015380	COG0772	Belongs to the SEDS family
AKL02_015385	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
AKL02_015390	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
AKL02_015395	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
AKL02_015400	COG0124	histidyl-tRNA synthetase
AKL02_015425	COG1529	Aldehyde oxidase and xanthine dehydrogenase
AKL02_015435	COG3845	ABC transporter
AKL02_015440	COG4603	Belongs to the binding-protein-dependent transport system permease family
AKL02_015450	COG1079	Belongs to the binding-protein-dependent transport system permease family
AKL02_015460	COG0446	pyridine nucleotide-disulphide oxidoreductase
AKL02_015480	COG0709	Synthesizes selenophosphate from selenide and ATP
AKL02_015485	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
AKL02_015490	COG1376	ErfK ybiS ycfS ynhG family protein
AKL02_015515	COG1136	(ABC) transporter
AKL02_015530	COG0408	coproporphyrinogen oxidase activity
AKL02_015540	COG0181	hydroxymethylbilane synthase activity
AKL02_015555	COG1028	Short-chain dehydrogenase reductase Sdr
AKL02_015560	COG2813	Specifically methylates the guanine in position
AKL02_015565	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
AKL02_015575	COG1686	Belongs to the peptidase S11 family
AKL02_015595	COG0348	domain, Protein
AKL02_015600	COG0583	DNA-binding transcription factor activity
AKL02_015610	COG2010	Cytochrome c
AKL02_015645	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AKL02_015650	COG0635	Involved in the biosynthesis of porphyrin-containing compound
AKL02_015660	COG1309	transcriptional regulator
AKL02_015665	COG0604	alcohol dehydrogenase
AKL02_015680	COG0175	sulfate reduction
AKL02_015690	COG0006	proline dipeptidase activity
AKL02_015695	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AKL02_015700	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
AKL02_015705	COG1414	Transcriptional regulator
AKL02_015710	COG3842	ATPase activity
AKL02_015715	COG0395	ABC-type sugar transport system, permease component
AKL02_015720	COG1175	transmembrane transport
AKL02_015780	COG0375	protein maturation
AKL02_015830	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
AKL02_015860	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
AKL02_015875	COG0438	transferase activity, transferring glycosyl groups
AKL02_015880	COG1215	transferase activity, transferring glycosyl groups
AKL02_015885	COG1215	transferase activity, transferring glycosyl groups
AKL02_015890	COG3206	protein involved in exopolysaccharide biosynthesis
AKL02_015890	COG0489	protein tyrosine kinase activity
AKL02_015900	COG1132	(ABC) transporter
AKL02_015930	COG1215	transferase activity, transferring glycosyl groups
AKL02_015935	COG1215	transferase activity, transferring glycosyl groups
AKL02_015940	COG2273	Hydrolase Family 16
AKL02_015945	COG3307	-O-antigen
AKL02_015980	COG1442	glycosyl transferase family 8
AKL02_016015	COG1872	DUF167
AKL02_016040	COG0346	lactoylglutathione lyase activity
AKL02_016055	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
AKL02_016060	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
AKL02_016065	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
AKL02_016085	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
AKL02_016090	COG0404	The glycine cleavage system catalyzes the degradation of glycine
AKL02_016115	COG0339	signal peptide processing
AKL02_016120	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
AKL02_016125	COG0756	dUTP diphosphatase activity
AKL02_016130	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
AKL02_016145	COG0606	chelatase, subunit chli
AKL02_016165	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
AKL02_016175	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
AKL02_016180	COG0728	peptidoglycan biosynthetic process
AKL02_016190	COG0180	Tryptophanyl-tRNA synthetase
AKL02_016200	COG0174	glutamine synthetase
AKL02_016205	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AKL02_016210	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
AKL02_016215	COG1832	CoA-binding protein
AKL02_016220	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AKL02_016255	COG1329	Transcriptional regulator
AKL02_016260	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
AKL02_016275	COG0457	Tetratricopeptide repeat
AKL02_016285	COG2267	carboxylic ester hydrolase activity
AKL02_016305	COG2308	Evidence 4 Homologs of previously reported genes of
AKL02_016325	COG1496	oxidoreductase activity
AKL02_016335	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
AKL02_016345	COG1702	phosphate starvation-inducible protein PhoH
AKL02_016380	COG2135	peptidase activity
AKL02_016395	COG1393	Belongs to the ArsC family
AKL02_016440	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
AKL02_016475	COG2176	DNA-directed DNA polymerase activity
AKL02_016475	COG5002	protein histidine kinase activity
AKL02_016480	COG0745	RESPONSE REGULATOR receiver
AKL02_016495	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AKL02_016510	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AKL02_016530	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
AKL02_016545	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
AKL02_016550	COG3706	GGDEF domain
AKL02_016625	COG0667	Aldo Keto reductase
AKL02_016635	COG1960	acyl-CoA dehydrogenase activity
AKL02_016645	COG0012	GTP binding
AKL02_016655	COG0159	tryptophan synthase activity
AKL02_016660	COG0842	Transport permease protein
AKL02_016675	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
AKL02_016685	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
AKL02_016700	COG0488	(ABC) transporter
AKL02_016710	COG1192	Involved in chromosome partitioning
AKL02_016720	COG0318	PFAM AMP-dependent synthetase and ligase
AKL02_016725	COG1132	(ABC) transporter
AKL02_016735	COG1024	Enoyl-CoA hydratase
AKL02_016740	COG0183	Belongs to the thiolase family
AKL02_016745	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AKL02_016755	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
AKL02_016760	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
AKL02_016770	COG0765	amino acid transport
AKL02_016775	COG0765	amino acid transport
AKL02_016790	COG0583	DNA-binding transcription factor activity
AKL02_016800	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
AKL02_016810	COG3088	subunit of a heme lyase
AKL02_016815	COG1138	Cytochrome C-type biogenesis protein
AKL02_016840	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AKL02_016840	COG0072	phenylalanine-tRNA ligase activity
AKL02_016865	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
AKL02_016880	COG0469	pyruvate kinase activity
AKL02_016905	COG4948	Mandelate Racemase Muconate Lactonizing
AKL02_016935	COG0640	Transcriptional regulator
AKL02_016950	COG2884	Cell division ATP-binding protein ftsE
AKL02_016965	COG0019	diaminopimelate decarboxylase activity
AKL02_016975	COG0165	Argininosuccinate lyase
AKL02_016980	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AKL02_016990	COG2200	EAL domain
AKL02_016990	COG2771	luxR family
AKL02_017000	COG1028	Short-chain dehydrogenase reductase Sdr
AKL02_017025	COG0142	geranyltranstransferase activity
AKL02_017030	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
AKL02_017045	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
AKL02_017075	COG0267	Belongs to the bacterial ribosomal protein bL33 family
AKL02_017110	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
AKL02_017115	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
AKL02_017120	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
AKL02_017125	COG0295	cytidine deaminase activity
AKL02_017130	COG0280	phosphate acetyltransferase
AKL02_017130	COG0281	malic enzyme
AKL02_017145	COG2204	response regulator
AKL02_017150	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
AKL02_017155	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
AKL02_017170	COG3038	cytochrome b561
AKL02_017200	COG0481	GTPase activity
AKL02_017215	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
AKL02_017220	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
AKL02_017225	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
AKL02_017235	COG1385	rRNA (uridine-N3-)-methyltransferase activity
AKL02_017240	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
AKL02_017245	COG2885	chlorophyll binding
AKL02_017255	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
AKL02_017265	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
AKL02_017270	COG3383	formate dehydrogenase (NAD+) activity
AKL02_017285	COG0616	signal peptide processing
AKL02_017285	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
AKL02_017305	COG0322	excinuclease ABC activity
AKL02_017310	COG1509	lysine 2,3-aminomutase activity
AKL02_017315	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
AKL02_017325	COG0314	molybdopterin synthase activity
AKL02_017345	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AKL02_017350	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
AKL02_017355	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
AKL02_017355	COG2169	Transcriptional regulator
AKL02_017360	COG2885	chlorophyll binding
AKL02_017370	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
AKL02_017385	COG0356	it plays a direct role in the translocation of protons across the membrane
AKL02_017435	COG0828	Belongs to the bacterial ribosomal protein bS21 family
AKL02_017440	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
AKL02_017445	COG1522	sequence-specific DNA binding
AKL02_017450	COG0686	Belongs to the AlaDH PNT family
AKL02_017455	COG1970	mechanosensitive ion channel activity
AKL02_017465	COG0483	inositol monophosphate 1-phosphatase activity
AKL02_017470	COG0583	DNA-binding transcription factor activity
AKL02_017500	COG0525	valine-tRNA ligase activity
AKL02_017510	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
AKL02_017520	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
AKL02_017525	COG1132	(ABC) transporter
AKL02_017530	COG0404	The glycine cleavage system catalyzes the degradation of glycine
AKL02_017550	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
AKL02_017565	COG1136	(ABC) transporter
AKL02_017565	COG0577	efflux transmembrane transporter activity
AKL02_017580	COG1309	transcriptional regulator
AKL02_017585	COG1618	nucleotide phosphatase activity, acting on free nucleotides
AKL02_017585	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
AKL02_017590	COG0288	reversible hydration of carbon dioxide
AKL02_017595	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
AKL02_017600	COG2181	nitrate reductase activity
AKL02_017605	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
AKL02_017615	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
AKL02_017680	COG0640	Transcriptional regulator
AKL02_017740	COG0583	DNA-binding transcription factor activity
AKL02_017745	COG2070	2-Nitropropane dioxygenase
AKL02_017750	COG3189	MarR family transcriptional regulator
AKL02_017760	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
AKL02_017765	COG2346	COG2346, Truncated hemoglobins
AKL02_017780	COG0635	Involved in the biosynthesis of porphyrin-containing compound
AKL02_017800	COG0287	Prephenate dehydrogenase
AKL02_017825	COG1172	Belongs to the binding-protein-dependent transport system permease family
AKL02_017830	COG1129	ABC transporter
AKL02_017855	COG0659	secondary active sulfate transmembrane transporter activity
AKL02_017865	COG0583	DNA-binding transcription factor activity
AKL02_017870	COG0583	DNA-binding transcription factor activity
AKL02_017890	COG1414	Transcriptional regulator
AKL02_017905	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
AKL02_017925	COG4585	Histidine kinase
AKL02_017945	COG0826	peptidase U32
AKL02_017985	COG3421	Type III restriction
AKL02_017990	COG2189	Belongs to the N(4) N(6)-methyltransferase family
AKL02_018000	COG2376	Dihydroxyacetone kinase
AKL02_018010	COG3959	Transketolase, thiamine diphosphate binding domain
AKL02_018015	COG3958	Transketolase
AKL02_018020	COG1028	Short-chain dehydrogenase reductase Sdr
AKL02_018025	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
AKL02_018035	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
AKL02_018040	COG0583	DNA-binding transcription factor activity
AKL02_018045	COG1349	DNA-binding transcription factor activity
AKL02_018075	COG1129	ABC transporter
AKL02_018080	COG1172	Belongs to the binding-protein-dependent transport system permease family
AKL02_018095	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
AKL02_018100	COG0698	ribose 5-phosphate isomerase
AKL02_018120	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AKL02_018125	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
AKL02_018130	COG1126	abc transporter atp-binding protein
AKL02_018135	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AKL02_018140	COG0765	amino acid transport
AKL02_018145	COG0765	amino acid transport
AKL02_018150	COG1609	Transcriptional regulator
AKL02_018160	COG0252	asparaginase activity
AKL02_018165	COG1268	BioY protein
AKL02_018170	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
AKL02_018175	COG1122	ATPase activity
AKL02_018180	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
AKL02_018195	COG1841	ribosomal large subunit assembly
AKL02_018200	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
AKL02_018205	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
AKL02_018210	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
AKL02_018215	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
AKL02_018220	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
AKL02_018225	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
AKL02_018230	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
AKL02_018245	COG0255	Belongs to the universal ribosomal protein uL29 family
AKL02_018260	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
AKL02_018265	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
AKL02_018270	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
AKL02_018275	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
AKL02_018280	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
AKL02_018290	COG0089	rRNA binding
AKL02_018295	COG0088	Forms part of the polypeptide exit tunnel
AKL02_018300	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
AKL02_018305	COG0051	transcription antitermination factor activity, RNA binding
AKL02_018310	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
AKL02_018315	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
AKL02_018325	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
AKL02_018330	COG0671	phosphoesterase, PA-phosphatase related
AKL02_018335	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
AKL02_018345	COG0463	Glycosyl transferase, family 2
AKL02_018355	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
AKL02_018360	COG0085	RNA polymerase activity
AKL02_018365	COG0222	ribosome binding
AKL02_018370	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
AKL02_018380	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
AKL02_018410	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AKL02_018430	COG1682	transport, permease protein
AKL02_018440	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
AKL02_018450	COG0693	protein deglycase activity
AKL02_018465	COG2267	carboxylic ester hydrolase activity
AKL02_018470	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
AKL02_018475	COG2124	cytochrome p450
AKL02_018480	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
AKL02_018490	COG0300	oxidoreductase activity
AKL02_018510	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
AKL02_018525	COG1183	phosphatidylcholine synthase activity
AKL02_018540	COG0101	tRNA pseudouridine synthase activity
AKL02_018545	COG1086	Polysaccharide biosynthesis protein
AKL02_018550	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
AKL02_018570	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
AKL02_018575	COG1214	PFAM Peptidase M22, glycoprotease
AKL02_018585	COG1744	ABC transporter substrate-binding protein PnrA-like
AKL02_018590	COG3845	ABC transporter
AKL02_018600	COG1079	Belongs to the binding-protein-dependent transport system permease family
AKL02_018610	COG0730	response to heat
AKL02_018620	COG1028	Short-chain dehydrogenase reductase Sdr
AKL02_018630	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
AKL02_018630	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
AKL02_018635	COG0604	alcohol dehydrogenase
AKL02_018690	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
AKL02_018700	COG1294	oxidase, subunit
AKL02_018725	COG1250	3-hydroxyacyl-CoA dehydrogenase
AKL02_018755	COG2205	protein histidine kinase activity
AKL02_018760	COG0745	RESPONSE REGULATOR receiver
AKL02_018765	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
AKL02_018770	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AKL02_018780	COG2153	protein acetylation
AKL02_018785	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AKL02_018810	COG1247	-acetyltransferase
AKL02_018830	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
AKL02_018840	COG0681	Belongs to the peptidase S26 family
AKL02_018845	COG0736	holo-[acyl-carrier-protein] synthase activity
AKL02_018850	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
AKL02_018855	COG0564	pseudouridine synthase activity
AKL02_018875	COG1366	Belongs to the anti-sigma-factor antagonist family
AKL02_018905	COG0436	Aminotransferase
AKL02_018915	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AKL02_018920	COG2835	tetraacyldisaccharide 4'-kinase activity
AKL02_018930	COG3118	belongs to the thioredoxin family
AKL02_018935	COG0708	Exodeoxyribonuclease III
AKL02_018945	COG0450	alkyl hydroperoxide reductase
AKL02_018950	COG1185	polyribonucleotide nucleotidyltransferase activity
AKL02_018960	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AKL02_018965	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
AKL02_018980	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
AKL02_018990	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
AKL02_018995	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
AKL02_019015	COG0138	bifunctional purine biosynthesis protein purh
AKL02_019020	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
AKL02_019030	COG0612	Peptidase, M16
AKL02_019035	COG0612	Peptidase, M16
AKL02_019040	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
AKL02_019050	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
AKL02_019050	COG0512	Glutamine amidotransferase of anthranilate synthase
AKL02_019065	COG0745	RESPONSE REGULATOR receiver
AKL02_019080	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
AKL02_019095	COG0495	leucyl-tRNA aminoacylation
AKL02_019125	COG0625	glutathione transferase activity
AKL02_019130	COG2271	Major facilitator Superfamily
AKL02_019140	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
AKL02_019145	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
AKL02_019150	COG0776	regulation of translation
AKL02_019160	COG2951	lytic endotransglycosylase activity
AKL02_019170	COG2171	N-acyltransferase activity
AKL02_019175	COG1611	Belongs to the LOG family
AKL02_019180	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
AKL02_019190	COG0820	rRNA (adenine-C2-)-methyltransferase activity
AKL02_019210	COG5443	negative regulation of bacterial-type flagellum assembly
AKL02_019220	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
AKL02_019260	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
AKL02_019270	COG0268	Binds directly to 16S ribosomal RNA
AKL02_019285	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
AKL02_019310	COG2132	Multicopper oxidase
AKL02_019330	COG2010	Cytochrome c
AKL02_019340	COG0714	Associated with various cellular activities
AKL02_019370	COG0667	Aldo Keto reductase
AKL02_019380	COG2376	Dihydroxyacetone kinase
AKL02_019390	COG1129	ABC transporter
AKL02_019400	COG1172	Belongs to the binding-protein-dependent transport system permease family
AKL02_019405	COG1609	Transcriptional regulator
AKL02_019455	COG2205	protein histidine kinase activity
AKL02_019460	COG0586	Pfam SNARE associated Golgi protein
AKL02_019465	COG4566	intracellular signal transduction
AKL02_019480	COG2442	InterPro IPR007367
AKL02_019495	COG3622	Belongs to the hyi family
AKL02_019500	COG3718	enzyme involved in inositol metabolism
AKL02_019505	COG1082	Xylose isomerase domain protein TIM barrel
AKL02_019510	COG3962	Belongs to the TPP enzyme family
AKL02_019515	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AKL02_019520	COG0673	inositol 2-dehydrogenase activity
AKL02_019540	COG0673	inositol 2-dehydrogenase activity
AKL02_019550	COG0812	UDP-N-acetylmuramate dehydrogenase activity
AKL02_019615	COG1012	belongs to the aldehyde dehydrogenase family
AKL02_019630	COG0697	spore germination
AKL02_019645	COG0655	NAD(P)H dehydrogenase (quinone) activity
AKL02_019650	COG0583	DNA-binding transcription factor activity
AKL02_019680	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AKL02_019680	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AKL02_019695	COG0577	efflux transmembrane transporter activity
AKL02_019695	COG1136	(ABC) transporter
AKL02_019705	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AKL02_019715	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AKL02_019720	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
AKL02_019720	COG1116	anion transmembrane transporter activity
AKL02_019725	COG0010	Belongs to the arginase family
AKL02_019745	COG0006	proline dipeptidase activity
AKL02_019755	COG1126	abc transporter atp-binding protein
AKL02_019760	COG0765	amino acid transport
AKL02_019765	COG0765	amino acid transport
AKL02_019770	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AKL02_019775	COG2188	Transcriptional regulator
AKL02_019785	COG4221	oxidoreductase activity
AKL02_019790	COG0784	Response regulator, receiver
AKL02_019820	COG3237	CsbD-like
AKL02_019855	COG2010	Cytochrome c
AKL02_019865	COG1295	ribonuclease BN
AKL02_019875	COG0729	surface antigen
AKL02_019880	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
AKL02_019890	COG3030	protein affecting phage T7 exclusion by the F plasmid
AKL02_019900	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
AKL02_019915	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
AKL02_019925	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
AKL02_019940	COG1074	ATP-dependent DNA helicase activity
AKL02_019945	COG2887	Belongs to the helicase family. UvrD subfamily
AKL02_019950	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
AKL02_019955	COG3178	'Phosphotransferase
AKL02_019960	COG0802	atpase or kinase
AKL02_019975	COG1999	signal sequence binding
AKL02_019990	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
AKL02_020005	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
AKL02_020030	COG0312	modulator of DNA gyrase
AKL02_020035	COG0483	inositol monophosphate 1-phosphatase activity
AKL02_020055	COG3220	belongs to the UPF0276 family
AKL02_020080	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
AKL02_020080	COG3008	intermembrane lipid transfer
AKL02_020085	COG2995	paraquat-inducible protein a
AKL02_020095	COG1360	Flagellar Motor Protein
AKL02_020100	COG1749	Flagellar hook protein flgE
AKL02_020115	COG1706	bacterial-type flagellum-dependent cell motility
AKL02_020150	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
AKL02_020155	COG2350	Protein conserved in bacteria
AKL02_020175	COG0573	inorganic phosphate transmembrane transporter activity
AKL02_020185	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
AKL02_020190	COG0704	Plays a role in the regulation of phosphate uptake
AKL02_020195	COG0745	RESPONSE REGULATOR receiver
AKL02_020200	COG0280	phosphate acetyltransferase
AKL02_020200	COG0281	malic enzyme
AKL02_020205	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
AKL02_020210	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
AKL02_020215	COG1420	regulation of RNA biosynthetic process
AKL02_020220	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
AKL02_020225	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
AKL02_020230	COG0635	Involved in the biosynthesis of porphyrin-containing compound
AKL02_020235	COG2832	Protein of unknown function (DUF454)
AKL02_020250	COG0357	Ribosomal RNA small subunit methyltransferase G
AKL02_020255	COG0445	tRNA wobble uridine modification
AKL02_020260	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
AKL02_020265	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
AKL02_020270	COG1981	membrane
AKL02_020275	COG0424	maF-like protein
AKL02_020280	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
AKL02_020285	COG0237	dephospho-CoA kinase activity
AKL02_020290	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
AKL02_020295	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
AKL02_020300	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
AKL02_020310	COG1051	belongs to the nudix hydrolase family
AKL02_020315	COG0793	Belongs to the peptidase S41A family
AKL02_020325	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
AKL02_020335	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
AKL02_020340	COG0799	negative regulation of ribosome biogenesis
AKL02_020345	COG3264	Mechanosensitive ion channel
AKL02_020345	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
AKL02_020355	COG0066	3-isopropylmalate dehydratase activity
AKL02_020380	COG0473	3-isopropylmalate dehydrogenase activity
AKL02_020385	COG0697	spore germination
AKL02_020435	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
AKL02_020450	COG4964	Belongs to the GSP D family
AKL02_020455	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AKL02_020515	COG0745	RESPONSE REGULATOR receiver
AKL02_020535	COG3421	Type III restriction
AKL02_020540	COG3421	Type III restriction
AKL02_020545	COG2189	Belongs to the N(4) N(6)-methyltransferase family
AKL02_020610	COG2217	Heavy metal translocating P-type atpase
AKL02_020615	COG0789	Transcriptional regulator
AKL02_020715	COG1859	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase
AKL02_020730	COG4372	Transposase
AKL02_020750	COG3436	PFAM IS66 Orf2 family protein
AKL02_020755	COG2433	Pfam Transposase IS66
AKL02_020765	COG3550	peptidyl-serine autophosphorylation
AKL02_020815	COG3609	addiction module antidote protein, CC2985 family
AKL02_020820	COG1414	Transcriptional regulator
AKL02_020825	COG1475	DNA binding
AKL02_020830	COG1192	Involved in chromosome partitioning
AKL02_020840	COG1653	transport
AKL02_020855	COG1653	transport
AKL02_020860	COG1175	transmembrane transport
AKL02_020865	COG0395	ABC-type sugar transport system, permease component
AKL02_020870	COG3842	ATPase activity
AKL02_020885	COG2267	carboxylic ester hydrolase activity
AKL02_020890	COG3395	kinase activity
AKL02_020895	COG0235	Class ii aldolase
AKL02_020900	COG3622	Belongs to the hyi family
AKL02_020915	COG1484	DNA-dependent DNA replication
AKL02_020920	COG2390	Transcriptional regulator
AKL02_020920	COG4584	PFAM Integrase catalytic
AKL02_020930	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
AKL02_020945	COG4598	ABC transporter
AKL02_020950	COG0765	amino acid transport
AKL02_020965	COG1802	Transcriptional regulator