locus-tag	class	description
Thivi_0001	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
Thivi_0003	COG0436	Aminotransferase
Thivi_0007	COG2183	response to ionizing radiation
Thivi_0013	COG1399	metal-binding, possibly nucleic acid-binding protein
Thivi_0014	COG0333	Belongs to the bacterial ribosomal protein bL32 family
Thivi_0015	COG0416	fatty acid biosynthetic process
Thivi_0016	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
Thivi_0019	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
Thivi_0020	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
Thivi_0021	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
Thivi_0022	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
Thivi_0023	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
Thivi_0026	COG0084	hydrolase, TatD family'
Thivi_0027	COG2995	paraquat-inducible protein a
Thivi_0028	COG3008	intermembrane lipid transfer
Thivi_0032	COG0745	RESPONSE REGULATOR receiver
Thivi_0033	COG2205	protein histidine kinase activity
Thivi_0036	COG0840	transmembrane signaling receptor activity
Thivi_0038	COG2205	protein histidine kinase activity
Thivi_0038	COG0784	Response regulator, receiver
Thivi_0038	COG2198	Histidine kinase
Thivi_0041	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
Thivi_0046	COG1132	(ABC) transporter
Thivi_0047	COG2843	Capsule synthesis protein
Thivi_0050	COG0439	Biotin carboxylase
Thivi_0053	COG4536	flavin adenine dinucleotide binding
Thivi_0057	COG0569	domain protein
Thivi_0058	COG1477	protein flavinylation
Thivi_0059	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
Thivi_0061	COG0730	response to heat
Thivi_0065	COG3706	GGDEF domain
Thivi_0070	COG4658	electron transport chain
Thivi_0072	COG2878	Part of a membrane complex involved in electron transport
Thivi_0073	COG4657	Part of a membrane complex involved in electron transport
Thivi_0076	COG2205	protein histidine kinase activity
Thivi_0081	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
Thivi_0082	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
Thivi_0083	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
Thivi_0088	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
Thivi_0090	COG3909	cytochrome
Thivi_0093	COG0720	synthase
Thivi_0094	COG0602	queuosine metabolic process
Thivi_0096	COG0617	tRNA 3'-terminal CCA addition
Thivi_0098	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
Thivi_0099	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
Thivi_0100	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
Thivi_0102	COG0297	glycogen (starch) synthase activity
Thivi_0103	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
Thivi_0105	COG0166	Belongs to the GPI family
Thivi_0106	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
Thivi_0115	COG3721	Heme iron utilization protein
Thivi_0117	COG0735	belongs to the Fur family
Thivi_0128	COG0438	transferase activity, transferring glycosyl groups
Thivi_0131	COG1215	transferase activity, transferring glycosyl groups
Thivi_0135	COG0438	transferase activity, transferring glycosyl groups
Thivi_0137	COG1216	Glycosyl transferase, family 2
Thivi_0153	COG0714	Associated with various cellular activities
Thivi_0156	COG0672	)-iron permease
Thivi_0163	COG3038	cytochrome b561
Thivi_0166	COG0739	heme binding
Thivi_0166	COG1196	nuclear chromosome segregation
Thivi_0166	COG0741	lytic transglycosylase activity
Thivi_0183	COG1459	type II secretion system
Thivi_0184	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
Thivi_0209	COG0546	phosphoglycolate phosphatase activity
Thivi_0210	COG0714	Associated with various cellular activities
Thivi_0214	COG0604	alcohol dehydrogenase
Thivi_0216	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
Thivi_0217	COG3830	Belongs to the UPF0237 family
Thivi_0217	COG0560	Phosphoserine phosphatase
Thivi_0219	COG1156	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit
Thivi_0221	COG1509	lysine 2,3-aminomutase activity
Thivi_0222	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
Thivi_0223	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
Thivi_0226	COG1408	metallophosphoesterase
Thivi_0231	COG2766	serine protein kinase
Thivi_0232	COG2718	Belongs to the UPF0229 family
Thivi_0233	COG2719	SpoVR family
Thivi_0235	COG2989	Protein conserved in bacteria
Thivi_0236	COG0418	dihydroorotase activity
Thivi_0237	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
Thivi_0239	COG0237	dephospho-CoA kinase activity
Thivi_0244	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
Thivi_0247	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
Thivi_0250	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
Thivi_0257	COG1294	oxidase, subunit
Thivi_0263	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
Thivi_0263	COG1263	PTS System
Thivi_0266	COG2270	Major facilitator Superfamily
Thivi_0267	COG4681	YaeQ
Thivi_0273	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
Thivi_0273	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
Thivi_0286	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
Thivi_0287	COG4251	negative regulation of phosphorylation
Thivi_0288	COG4251	negative regulation of phosphorylation
Thivi_0289	COG5002	protein histidine kinase activity
Thivi_0290	COG4566	intracellular signal transduction
Thivi_0292	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
Thivi_0298	COG0306	phosphate transporter
Thivi_0299	COG1392	Phosphate transport regulator
Thivi_0300	COG0776	regulation of translation
Thivi_0301	COG0539	negative regulation of cytoplasmic translation
Thivi_0302	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
Thivi_0303	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
Thivi_0307	COG0840	transmembrane signaling receptor activity
Thivi_0308	COG0745	RESPONSE REGULATOR receiver
Thivi_0310	COG2198	Histidine kinase
Thivi_0310	COG0643	Histidine kinase
Thivi_0311	COG0840	transmembrane signaling receptor activity
Thivi_0312	COG0835	chemotaxis
Thivi_0313	COG2076	Multidrug Resistance protein
Thivi_0314	COG2201	protein-glutamate methylesterase activity
Thivi_0316	COG5002	protein histidine kinase activity
Thivi_0316	COG3447	MASE1 domain protein
Thivi_0316	COG5001	Diguanylate cyclase
Thivi_0317	COG2198	Histidine kinase
Thivi_0317	COG0643	Histidine kinase
Thivi_0318	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
Thivi_0319	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
Thivi_0320	COG2201	protein-glutamate methylesterase activity
Thivi_0323	COG2201	protein-glutamate methylesterase activity
Thivi_0325	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
Thivi_0327	COG2198	Histidine kinase
Thivi_0327	COG0643	Histidine kinase
Thivi_0329	COG0745	RESPONSE REGULATOR receiver
Thivi_0330	COG0840	transmembrane signaling receptor activity
Thivi_0331	COG1366	Belongs to the anti-sigma-factor antagonist family
Thivi_0332	COG1366	Belongs to the anti-sigma-factor antagonist family
Thivi_0333	COG2172	sigma factor antagonist activity
Thivi_0334	COG2172	sigma factor antagonist activity
Thivi_0337	COG0745	RESPONSE REGULATOR receiver
Thivi_0338	COG1192	Involved in chromosome partitioning
Thivi_0339	COG0840	transmembrane signaling receptor activity
Thivi_0357	COG1677	Flagellar hook-basal body complex protein FliE
Thivi_0358	COG1766	The M ring may be actively involved in energy transduction
Thivi_0359	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
Thivi_0370	COG1684	flagellar biosynthetic protein fliR
Thivi_0372	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
Thivi_0374	COG0455	bacterial-type flagellum organization
Thivi_0377	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
Thivi_0380	COG0643	Histidine kinase
Thivi_0380	COG2198	Histidine kinase
Thivi_0381	COG2201	protein-glutamate methylesterase activity
Thivi_0382	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
Thivi_0383	COG1360	Flagellar Motor Protein
Thivi_0386	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
Thivi_0392	COG0784	Response regulator, receiver
Thivi_0392	COG0835	chemotaxis
Thivi_0393	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
Thivi_0395	COG1815	bacterial-type flagellum-dependent cell motility
Thivi_0396	COG1558	bacterial-type flagellum-dependent cell motility
Thivi_0397	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
Thivi_0398	COG1749	Flagellar hook protein flgE
Thivi_0400	COG4786	Flagellar basal body rod
Thivi_0401	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
Thivi_0402	COG1706	bacterial-type flagellum-dependent cell motility
Thivi_0403	COG1705	Flagellar rod assembly protein muramidase FlgJ
Thivi_0403	COG3951	Flagellar rod assembly protein muramidase FlgJ
Thivi_0405	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
Thivi_0408	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
Thivi_0409	COG1923	regulation of RNA biosynthetic process
Thivi_0410	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
Thivi_0411	COG0330	HflC and HflK could
Thivi_0412	COG0330	HflC and HflK could
Thivi_0415	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
Thivi_0416	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
Thivi_0423	COG5433	transposase activity
Thivi_0426	COG0454	-acetyltransferase
Thivi_0430	COG3093	addiction module antidote protein HigA
Thivi_0436	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
Thivi_0438	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
Thivi_0439	COG0840	transmembrane signaling receptor activity
Thivi_0439	COG0840	transmembrane signaling receptor activity
Thivi_0440	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
Thivi_0441	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
Thivi_0443	COG1272	protein, Hemolysin III
Thivi_0444	COG2900	Belongs to the SlyX family
Thivi_0447	COG0735	belongs to the Fur family
Thivi_0450	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
Thivi_0456	COG1203	CRISPR-associated helicase, Cas3
Thivi_0459	COG1857	crispr-associated protein
Thivi_0465	COG1518	maintenance of DNA repeat elements
Thivi_0466	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
Thivi_0467	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
Thivi_0470	COG0673	inositol 2-dehydrogenase activity
Thivi_0475	COG0268	Binds directly to 16S ribosomal RNA
Thivi_0476	COG1125	glycine betaine transport
Thivi_0476	COG0517	IMP dehydrogenase activity
Thivi_0479	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
Thivi_0481	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
Thivi_0482	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
Thivi_0488	COG0300	oxidoreductase activity
Thivi_0490	COG2885	chlorophyll binding
Thivi_0490	COG3047	cAMP biosynthetic process
Thivi_0491	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
Thivi_0492	COG0857	belongs to the CobB CobQ family
Thivi_0492	COG0280	phosphate acetyltransferase
Thivi_0494	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
Thivi_0494	COG2111	Na H antiporter
Thivi_0495	COG0650	Formate hydrogenlyase subunit 4
Thivi_0496	COG3260	NADH ubiquinone oxidoreductase 20
Thivi_0497	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
Thivi_0498	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
Thivi_0498	COG3261	NADH dehydrogenase
Thivi_0500	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
Thivi_0501	COG1592	Rubrerythrin
Thivi_0503	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
Thivi_0504	COG0585	pseudouridine synthase activity
Thivi_0508	COG2010	Cytochrome c
Thivi_0512	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
Thivi_0515	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
Thivi_0516	COG0557	exoribonuclease II activity
Thivi_0518	COG4106	trans-aconitate 2-methyltransferase activity
Thivi_0526	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
Thivi_0527	COG1132	(ABC) transporter
Thivi_0528	COG0704	Plays a role in the regulation of phosphate uptake
Thivi_0529	COG2203	Gaf domain
Thivi_0529	COG2199	diguanylate cyclase activity
Thivi_0529	COG2200	EAL domain
Thivi_0530	COG0840	transmembrane signaling receptor activity
Thivi_0533	COG1028	Short-chain dehydrogenase reductase Sdr
Thivi_0534	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
Thivi_0536	COG1210	Utp--glucose-1-phosphate uridylyltransferase
Thivi_0539	COG2920	part of a sulfur-relay system
Thivi_0544	COG2221	Nitrite and sulphite reductase 4Fe-4S
Thivi_0545	COG2221	Nitrite and sulphite reductase 4Fe-4S
Thivi_0546	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
Thivi_0547	COG2923	Belongs to the DsrF TusC family
Thivi_0549	COG2920	part of a sulfur-relay system
Thivi_0556	COG1797	cobyrinic acid a,c-diamide synthase activity
Thivi_0558	COG1350	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
Thivi_0560	COG0745	RESPONSE REGULATOR receiver
Thivi_0565	COG2957	Belongs to the agmatine deiminase family
Thivi_0568	COG0670	Belongs to the BI1 family
Thivi_0587	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
Thivi_0590	COG0732	type I restriction modification DNA specificity domain
Thivi_0591	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
Thivi_0595	COG5433	transposase activity
Thivi_0596	COG0582	viral genome integration into host DNA
Thivi_0598	COG0123	including yeast histone deacetylase and acetoin utilization protein
Thivi_0605	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
Thivi_0606	COG0481	GTPase activity
Thivi_0607	COG0681	Belongs to the peptidase S26 family
Thivi_0611	COG1381	Involved in DNA repair and RecF pathway recombination
Thivi_0612	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
Thivi_0614	COG1404	Belongs to the peptidase S8 family
Thivi_0615	COG0243	molybdopterin cofactor binding
Thivi_0617	COG1534	Rna-binding protein
Thivi_0618	COG0033	Phosphoglucomutase
Thivi_0619	COG0326	Molecular chaperone. Has ATPase activity
Thivi_0620	COG0563	adenylate kinase activity
Thivi_0621	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
Thivi_0623	COG1959	2 iron, 2 sulfur cluster binding
Thivi_0628	COG0740	serine-type endopeptidase activity
Thivi_0629	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
Thivi_0630	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
Thivi_0631	COG0776	regulation of translation
Thivi_0634	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
Thivi_0635	COG2086	electron transfer activity
Thivi_0636	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
Thivi_0637	COG1960	acyl-CoA dehydrogenase activity
Thivi_0638	COG2304	oxidoreductase activity
Thivi_0640	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
Thivi_0642	COG3706	GGDEF domain
Thivi_0644	COG4999	Histidine kinase
Thivi_0644	COG3850	Histidine kinase
Thivi_0644	COG3437	response regulator, receiver
Thivi_0644	COG2205	protein histidine kinase activity
Thivi_0645	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
Thivi_0646	COG0745	RESPONSE REGULATOR receiver
Thivi_0650	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
Thivi_0653	COG1131	(ABC) transporter
Thivi_0655	COG1286	toxin biosynthetic process
Thivi_0660	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
Thivi_0663	COG0071	Belongs to the small heat shock protein (HSP20) family
Thivi_0669	COG0217	transcriptional regulatory protein
Thivi_0671	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
Thivi_0672	COG0632	four-way junction helicase activity
Thivi_0674	COG0277	FAD linked oxidase domain protein
Thivi_0675	COG0247	lactate metabolic process
Thivi_0676	COG2084	Dehydrogenase
Thivi_0678	COG3876	Protein conserved in bacteria
Thivi_0679	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
Thivi_0681	COG0513	Belongs to the DEAD box helicase family
Thivi_0682	COG0724	RNA recognition motif
Thivi_0684	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
Thivi_0684	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
Thivi_0686	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
Thivi_0689	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
Thivi_0690	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
Thivi_0693	COG0784	Response regulator, receiver
Thivi_0693	COG5002	protein histidine kinase activity
Thivi_0693	COG2205	protein histidine kinase activity
Thivi_0696	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
Thivi_0697	COG2354	Protein conserved in bacteria
Thivi_0701	COG2862	Uncharacterized protein family, UPF0114
Thivi_0702	COG2203	Gaf domain
Thivi_0702	COG4251	negative regulation of phosphorylation
Thivi_0702	COG3706	GGDEF domain
Thivi_0702	COG5001	Diguanylate cyclase
Thivi_0705	COG2814	Major facilitator Superfamily
Thivi_0711	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
Thivi_0713	COG2337	Toxic component of a toxin-antitoxin (TA) module
Thivi_0714	COG2336	PFAM SpoVT AbrB
Thivi_0715	COG4206	TonB-dependent receptor
Thivi_0717	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
Thivi_0721	COG0658	competence protein
Thivi_0721	COG2333	competence protein COMEC
Thivi_0724	COG1136	(ABC) transporter
Thivi_0725	COG4591	ABC-type transport system involved in lipoprotein release permease component
Thivi_0726	COG0795	lipopolysaccharide-transporting ATPase activity
Thivi_0728	COG0308	aminopeptidase N
Thivi_0735	COG3174	membrane
Thivi_0738	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
Thivi_0739	COG0676	glucose-6-phosphate 1-epimerase activity
Thivi_0740	COG3459	Glycosyltransferase 36 associated
Thivi_0742	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
Thivi_0743	COG0527	aspartate kinase activity
Thivi_0744	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
Thivi_0745	COG2137	regulation of response to DNA damage stimulus
Thivi_0747	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
Thivi_0748	COG1546	Belongs to the CinA family
Thivi_0749	COG0457	Tetratricopeptide repeat
Thivi_0749	COG0515	serine threonine protein kinase
Thivi_0754	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
Thivi_0756	COG0463	Glycosyl transferase, family 2
Thivi_0757	COG3028	Belongs to the UPF0307 family
Thivi_0759	COG0577	efflux transmembrane transporter activity
Thivi_0759	COG1136	(ABC) transporter
Thivi_0760	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
Thivi_0769	COG0271	Belongs to the BolA IbaG family
Thivi_0771	COG1115	amino acid carrier protein
Thivi_0775	COG1334	flagellar protein FlaG
Thivi_0781	COG5002	protein histidine kinase activity
Thivi_0782	COG0745	RESPONSE REGULATOR receiver
Thivi_0797	COG0457	Tetratricopeptide repeat
Thivi_0801	COG2801	Transposase and inactivated derivatives
Thivi_0804	COG3956	TIGRFAM MazG family protein
Thivi_0806	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
Thivi_0810	COG0589	response to stress
Thivi_0813	COG1136	(ABC) transporter
Thivi_0813	COG0577	efflux transmembrane transporter activity
Thivi_0833	COG1943	Transposase
Thivi_0836	COG3118	belongs to the thioredoxin family
Thivi_0838	COG0037	tRNA processing
Thivi_0840	COG0825	malonyl-CoA metabolic process
Thivi_0849	COG4191	Histidine kinase
Thivi_0850	COG4566	intracellular signal transduction
Thivi_0851	COG1943	Transposase
Thivi_0858	COG1342	Belongs to the UPF0251 family
Thivi_0859	COG0723	plastoquinol--plastocyanin reductase activity
Thivi_0863	COG2894	cell division
Thivi_0871	COG4566	intracellular signal transduction
Thivi_0874	COG2304	oxidoreductase activity
Thivi_0877	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
Thivi_0885	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
Thivi_0887	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
Thivi_0890	COG0386	Belongs to the glutathione peroxidase family
Thivi_0891	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
Thivi_0892	COG0671	phosphoesterase, PA-phosphatase related
Thivi_0893	COG2046	Belongs to the sulfate adenylyltransferase family
Thivi_0895	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
Thivi_0896	COG3108	Peptidase M15
Thivi_0897	COG0557	exoribonuclease II activity
Thivi_0900	COG0493	'glutamate synthase
Thivi_0902	COG0601	transmembrane transport
Thivi_0903	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
Thivi_0913	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
Thivi_0914	COG0285	dihydrofolate synthase activity
Thivi_0915	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
Thivi_0916	COG0159	tryptophan synthase activity
Thivi_0917	COG0133	tryptophan synthase activity
Thivi_0918	COG0135	phosphoribosylanthranilate isomerase activity
Thivi_0919	COG0101	tRNA pseudouridine synthase activity
Thivi_0922	COG0473	3-isopropylmalate dehydrogenase activity
Thivi_0923	COG0066	3-isopropylmalate dehydratase activity
Thivi_0924	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
Thivi_0925	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
Thivi_0928	COG0577	efflux transmembrane transporter activity
Thivi_0928	COG1136	(ABC) transporter
Thivi_0929	COG0577	efflux transmembrane transporter activity
Thivi_0929	COG1136	(ABC) transporter
Thivi_0930	COG1136	(ABC) transporter
Thivi_0930	COG0577	efflux transmembrane transporter activity
Thivi_0932	COG0735	belongs to the Fur family
Thivi_0933	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
Thivi_0934	COG2914	Belongs to the UPF0125 (RnfH) family
Thivi_0935	COG2867	negative regulation of translational initiation
Thivi_0936	COG0733	neurotransmitter:sodium symporter activity
Thivi_0937	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
Thivi_0938	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
Thivi_0939	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
Thivi_0942	COG0791	NLP P60 protein
Thivi_0943	COG0492	ferredoxin-NADP+ reductase activity
Thivi_0945	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
Thivi_0946	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
Thivi_0947	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
Thivi_0963	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
Thivi_0967	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
Thivi_0968	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
Thivi_0969	COG0581	inorganic phosphate transmembrane transporter activity
Thivi_0970	COG0573	inorganic phosphate transmembrane transporter activity
Thivi_0973	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
Thivi_0974	COG0058	SHG alpha-glucan phosphorylase activity
Thivi_0975	COG2326	polyphosphate kinase activity
Thivi_0977	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
Thivi_0978	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
Thivi_0982	COG4636	protein conserved in cyanobacteria
Thivi_0983	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
Thivi_0985	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
Thivi_0986	COG0495	leucyl-tRNA aminoacylation
Thivi_0988	COG0542	response to heat
Thivi_0992	COG0501	Belongs to the peptidase M48B family
Thivi_0994	COG0302	gtp cyclohydrolase
Thivi_0995	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
Thivi_1004	COG0028	Belongs to the TPP enzyme family
Thivi_1006	COG0442	prolyl-tRNA aminoacylation
Thivi_1007	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
Thivi_1009	COG5002	protein histidine kinase activity
Thivi_1009	COG2205	protein histidine kinase activity
Thivi_1009	COG0784	Response regulator, receiver
Thivi_1010	COG3437	response regulator, receiver
Thivi_1011	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
Thivi_1015	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
Thivi_1018	COG0455	bacterial-type flagellum organization
Thivi_1019	COG1192	Involved in chromosome partitioning
Thivi_1022	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
Thivi_1024	COG2379	hydroxypyruvate reductase
Thivi_1026	COG0494	nUDIX hydrolase
Thivi_1027	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
Thivi_1029	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
Thivi_1030	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
Thivi_1031	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
Thivi_1032	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
Thivi_1032	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
Thivi_1036	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
Thivi_1037	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
Thivi_1040	COG2217	Heavy metal translocating P-type atpase
Thivi_1044	COG2010	Cytochrome c
Thivi_1047	COG3278	Belongs to the heme-copper respiratory oxidase family
Thivi_1048	COG2212	antiporter activity
Thivi_1049	COG1320	monovalent cation:proton antiporter activity
Thivi_1052	COG1006	Multisubunit Na H antiporter MnhC subunit
Thivi_1053	COG0651	ATP synthesis coupled electron transport
Thivi_1054	COG0651	ATP synthesis coupled electron transport
Thivi_1056	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
Thivi_1057	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
Thivi_1058	COG0649	NAD binding
Thivi_1062	COG1863	multisubunit Na H antiporter MnhE subunit
Thivi_1065	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
Thivi_1069	COG2835	tetraacyldisaccharide 4'-kinase activity
Thivi_1073	COG1518	maintenance of DNA repeat elements
Thivi_1079	COG1203	CRISPR-associated helicase, Cas3
Thivi_1084	COG2151	metal-sulfur cluster biosynthetic enzyme
Thivi_1085	COG0719	Fe-S assembly protein
Thivi_1086	COG0396	ATPase activity
Thivi_1087	COG0719	Fe-S assembly protein
Thivi_1090	COG2200	EAL domain
Thivi_1095	COG1324	tolerance protein
Thivi_1096	COG4232	protein-disulfide reductase activity
Thivi_1097	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
Thivi_1099	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
Thivi_1100	COG0511	ligase activity, forming carbon-carbon bonds
Thivi_1101	COG0439	Biotin carboxylase
Thivi_1104	COG2189	Belongs to the N(4) N(6)-methyltransferase family
Thivi_1108	COG4106	trans-aconitate 2-methyltransferase activity
Thivi_1110	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
Thivi_1112	COG0138	bifunctional purine biosynthesis protein purh
Thivi_1113	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
Thivi_1115	COG0151	Belongs to the GarS family
Thivi_1120	COG3178	'Phosphotransferase
Thivi_1121	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
Thivi_1122	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
Thivi_1123	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
Thivi_1124	COG1183	phosphatidylcholine synthase activity
Thivi_1125	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
Thivi_1128	COG1034	ATP synthesis coupled electron transport
Thivi_1129	COG1941	NADH ubiquinone oxidoreductase 20 kDa subunit
Thivi_1131	COG3259	Nickel-dependent hydrogenase
Thivi_1133	COG1028	Short-chain dehydrogenase reductase Sdr
Thivi_1134	COG1254	Belongs to the acylphosphatase family
Thivi_1138	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
Thivi_1139	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
Thivi_1140	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
Thivi_1146	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
Thivi_1147	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
Thivi_1149	COG0180	Tryptophanyl-tRNA synthetase
Thivi_1150	COG1994	Peptidase M50
Thivi_1151	COG0009	L-threonylcarbamoyladenylate synthase
Thivi_1152	COG0613	PHP domain protein
Thivi_1157	COG3100	YcgL domain-containing protein
Thivi_1157	COG0561	phosphatase activity
Thivi_1158	COG0438	transferase activity, transferring glycosyl groups
Thivi_1159	COG0811	peptide transport
Thivi_1164	COG0004	ammonium transporteR
Thivi_1166	COG0310	cobalt ion transport
Thivi_1167	COG0310	cobalt ion transport
Thivi_1174	COG0864	Transcriptional regulator
Thivi_1177	COG2308	Evidence 4 Homologs of previously reported genes of
Thivi_1181	COG0305	Participates in initiation and elongation during chromosome replication
Thivi_1182	COG0359	binds to the 23S rRNA
Thivi_1185	COG0360	Binds together with S18 to 16S ribosomal RNA
Thivi_1194	COG1396	sequence-specific DNA binding
Thivi_1197	COG5433	transposase activity
Thivi_1198	COG2716	regulation of RNA biosynthetic process
Thivi_1199	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
Thivi_1200	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
Thivi_1202	COG3437	response regulator, receiver
Thivi_1205	COG5002	protein histidine kinase activity
Thivi_1205	COG2205	protein histidine kinase activity
Thivi_1205	COG0784	Response regulator, receiver
Thivi_1207	COG3437	response regulator, receiver
Thivi_1211	COG0840	transmembrane signaling receptor activity
Thivi_1213	COG2204	response regulator
Thivi_1215	COG5002	protein histidine kinase activity
Thivi_1215	COG2205	protein histidine kinase activity
Thivi_1215	COG0784	Response regulator, receiver
Thivi_1217	COG2205	protein histidine kinase activity
Thivi_1218	COG2201	protein-glutamate methylesterase activity
Thivi_1220	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
Thivi_1222	COG0840	transmembrane signaling receptor activity
Thivi_1223	COG0835	chemotaxis
Thivi_1224	COG2198	Histidine kinase
Thivi_1224	COG0643	Histidine kinase
Thivi_1225	COG0745	RESPONSE REGULATOR receiver
Thivi_1226	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
Thivi_1247	COG1752	Esterase of the alpha-beta hydrolase superfamily
Thivi_1250	COG5001	Diguanylate cyclase
Thivi_1253	COG0542	response to heat
Thivi_1258	COG0277	FAD linked oxidase domain protein
Thivi_1262	COG1242	4 iron, 4 sulfur cluster binding
Thivi_1268	COG2308	Evidence 4 Homologs of previously reported genes of
Thivi_1274	COG0745	RESPONSE REGULATOR receiver
Thivi_1274	COG3706	GGDEF domain
Thivi_1276	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
Thivi_1280	COG2917	probably involved in intracellular septation
Thivi_1281	COG2350	Protein conserved in bacteria
Thivi_1282	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
Thivi_1284	COG3005	denitrification pathway
Thivi_1295	COG1943	Transposase
Thivi_1303	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
Thivi_1308	COG5433	transposase activity
Thivi_1311	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
Thivi_1317	COG4771	TonB-dependent receptor
Thivi_1318	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
Thivi_1319	COG4999	Histidine kinase
Thivi_1319	COG3850	Histidine kinase
Thivi_1319	COG3437	response regulator, receiver
Thivi_1319	COG2205	protein histidine kinase activity
Thivi_1323	COG5001	Diguanylate cyclase
Thivi_1323	COG5002	protein histidine kinase activity
Thivi_1324	COG0366	Alpha amylase catalytic
Thivi_1324	COG1874	Beta-galactosidase
Thivi_1325	COG0616	signal peptide processing
Thivi_1326	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
Thivi_1328	COG0688	phosphatidylethanolamine metabolic process
Thivi_1329	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
Thivi_1337	COG1840	ABC-type Fe3 transport system, periplasmic component
Thivi_1355	COG0628	permease
Thivi_1357	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
Thivi_1358	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
Thivi_1359	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
Thivi_1361	COG0415	Belongs to the DNA photolyase family
Thivi_1364	COG1968	undecaprenyl-diphosphatase activity
Thivi_1365	COG2983	Belongs to the UPF0260 family
Thivi_1368	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
Thivi_1371	COG2610	gluconate transmembrane transporter activity
Thivi_1378	COG0651	ATP synthesis coupled electron transport
Thivi_1379	COG3710	Transcriptional regulator
Thivi_1383	COG5001	Diguanylate cyclase
Thivi_1383	COG5002	protein histidine kinase activity
Thivi_1388	COG2015	COG2015, Alkyl sulfatase and related hydrolases
Thivi_1392	COG2235	arginine
Thivi_1399	COG0628	permease
Thivi_1401	COG0786	glutamate:sodium symporter activity
Thivi_1403	COG2066	Belongs to the glutaminase family
Thivi_1404	COG0583	DNA-binding transcription factor activity
Thivi_1405	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
Thivi_1407	COG0175	sulfate reduction
Thivi_1409	COG0277	FAD linked oxidase domain protein
Thivi_1411	COG0729	surface antigen
Thivi_1413	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
Thivi_1415	COG0789	Transcriptional regulator
Thivi_1418	COG5433	transposase activity
Thivi_1421	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
Thivi_1422	COG0071	Belongs to the small heat shock protein (HSP20) family
Thivi_1436	COG4771	TonB-dependent receptor
Thivi_1460	COG5433	transposase activity
Thivi_1475	COG1196	nuclear chromosome segregation
Thivi_1500	COG0681	Belongs to the peptidase S26 family
Thivi_1513	COG4115	mRNA cleavage
Thivi_1523	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
Thivi_1542	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
Thivi_1559	COG0776	regulation of translation
Thivi_1560	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
Thivi_1560	COG0072	phenylalanine-tRNA ligase activity
Thivi_1561	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
Thivi_1563	COG0291	Belongs to the bacterial ribosomal protein bL35 family
Thivi_1565	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
Thivi_1568	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
Thivi_1570	COG1850	ribulose-bisphosphate carboxylase activity
Thivi_1575	COG2255	four-way junction helicase activity
Thivi_1576	COG0277	FAD linked oxidase domain protein
Thivi_1600	COG0739	heme binding
Thivi_1604	COG2197	response regulator
Thivi_1624	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
Thivi_1630	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
Thivi_1640	COG5433	transposase activity
Thivi_1658	COG5433	transposase activity
Thivi_1666	COG0640	Transcriptional regulator
Thivi_1667	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
Thivi_1668	COG0798	PFAM Bile acid sodium symporter
Thivi_1669	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
Thivi_1675	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
Thivi_1685	COG0583	DNA-binding transcription factor activity
Thivi_1686	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
Thivi_1690	COG4679	PFAM Phage derived protein Gp49-like (DUF891)
Thivi_1692	COG1280	lysine exporter protein (LysE YggA)
Thivi_1696	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
Thivi_1697	COG1797	cobyrinic acid a,c-diamide synthase activity
Thivi_1700	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
Thivi_1701	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
Thivi_1708	COG1492	cobalamin metabolic process
Thivi_1719	COG3437	response regulator, receiver
Thivi_1720	COG3850	Histidine kinase
Thivi_1720	COG2205	protein histidine kinase activity
Thivi_1720	COG4999	Histidine kinase
Thivi_1720	COG3437	response regulator, receiver
Thivi_1722	COG0517	IMP dehydrogenase activity
Thivi_1722	COG0516	GMP reductase activity
Thivi_1723	COG1278	Cold shock
Thivi_1724	COG0488	(ABC) transporter
Thivi_1725	COG0446	pyridine nucleotide-disulphide oxidoreductase
Thivi_1729	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
Thivi_1730	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
Thivi_1732	COG2226	methyltransferase
Thivi_1735	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
Thivi_1736	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
Thivi_1740	COG0367	asparagine synthase
Thivi_1743	COG5002	protein histidine kinase activity
Thivi_1743	COG2205	protein histidine kinase activity
Thivi_1743	COG0784	Response regulator, receiver
Thivi_1748	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
Thivi_1750	COG2814	Major facilitator Superfamily
Thivi_1751	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
Thivi_1752	COG1538	Outer membrane efflux protein
Thivi_1753	COG0429	hydrolase of the alpha beta-hydrolase fold
Thivi_1755	COG0746	molybdenum cofactor guanylyltransferase activity
Thivi_1756	COG0071	Belongs to the small heat shock protein (HSP20) family
Thivi_1758	COG2308	Evidence 4 Homologs of previously reported genes of
Thivi_1758	COG2307	Protein conserved in bacteria
Thivi_1761	COG1040	competence protein
Thivi_1762	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
Thivi_1763	COG0156	8-amino-7-oxononanoate synthase activity
Thivi_1764	COG0596	Alpha beta hydrolase
Thivi_1765	COG2226	methyltransferase
Thivi_1768	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
Thivi_1769	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
Thivi_1770	COG0505	Belongs to the CarA family
Thivi_1778	COG1390	Produces ATP from ADP in the presence of a proton gradient across the membrane
Thivi_1779	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
Thivi_1786	COG1156	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit
Thivi_1788	COG1394	ATPase activity, coupled to movement of substances
Thivi_1789	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
Thivi_1792	COG0823	Involved in the tonB-independent uptake of proteins
Thivi_1796	COG0824	Thioesterase
Thivi_1799	COG0318	PFAM AMP-dependent synthetase and ligase
Thivi_1803	COG1528	Iron-storage protein
Thivi_1804	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
Thivi_1805	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
Thivi_1806	COG0795	lipopolysaccharide-transporting ATPase activity
Thivi_1807	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
Thivi_1808	COG0084	hydrolase, TatD family'
Thivi_1810	COG3122	Protein conserved in bacteria
Thivi_1812	COG0446	pyridine nucleotide-disulphide oxidoreductase
Thivi_1815	COG0446	pyridine nucleotide-disulphide oxidoreductase
Thivi_1820	COG1131	(ABC) transporter
Thivi_1824	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
Thivi_1825	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
Thivi_1826	COG1477	protein flavinylation
Thivi_1838	COG0404	The glycine cleavage system catalyzes the degradation of glycine
Thivi_1839	COG0509	glycine decarboxylation via glycine cleavage system
Thivi_1840	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
Thivi_1841	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
Thivi_1842	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
Thivi_1843	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
Thivi_1845	COG1240	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
Thivi_1847	COG1035	Coenzyme F420 hydrogenase/dehydrogenase, beta subunit C terminus
Thivi_1848	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
Thivi_1850	COG4535	Mg2 and Co2 transporter CorC
Thivi_1851	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
Thivi_1852	COG1702	phosphate starvation-inducible protein PhoH
Thivi_1853	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
Thivi_1858	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
Thivi_1859	COG2853	Lipoprotein
Thivi_1863	COG5002	protein histidine kinase activity
Thivi_1863	COG0784	Response regulator, receiver
Thivi_1863	COG2198	Histidine kinase
Thivi_1865	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
Thivi_1868	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
Thivi_1869	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
Thivi_1874	COG2373	Large extracellular alpha-helical protein
Thivi_1878	COG4145	pantothenate transmembrane transporter activity
Thivi_1898	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
Thivi_1899	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
Thivi_1901	COG0737	Belongs to the 5'-nucleotidase family
Thivi_1904	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
Thivi_1905	COG0129	dihydroxy-acid dehydratase activity
Thivi_1917	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
Thivi_1920	COG2027	D-alanyl-D-alanine carboxypeptidase
Thivi_1921	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
Thivi_1922	COG1047	Peptidyl-prolyl cis-trans
Thivi_1925	COG3954	Phosphoribulokinase
Thivi_1926	COG2205	protein histidine kinase activity
Thivi_1926	COG4999	Histidine kinase
Thivi_1926	COG3850	Histidine kinase
Thivi_1926	COG3437	response regulator, receiver
Thivi_1928	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
Thivi_1930	COG4657	Part of a membrane complex involved in electron transport
Thivi_1931	COG2878	Part of a membrane complex involved in electron transport
Thivi_1934	COG4658	electron transport chain
Thivi_1935	COG4659	FMN binding
Thivi_1936	COG4660	Part of a membrane complex involved in electron transport
Thivi_1937	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
Thivi_1938	COG2827	Endonuclease containing a URI domain
Thivi_1952	COG1943	Transposase
Thivi_1955	COG0625	glutathione transferase activity
Thivi_1956	COG1414	Transcriptional regulator
Thivi_1961	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
Thivi_1969	COG1584	GPR1 FUN34 yaaH family protein
Thivi_1972	COG0708	Exodeoxyribonuclease III
Thivi_1974	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
Thivi_1978	COG2814	Major facilitator Superfamily
Thivi_1990	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
Thivi_1991	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
Thivi_1992	COG1850	ribulose-bisphosphate carboxylase activity
Thivi_2003	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
Thivi_2010	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
Thivi_2011	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
Thivi_2013	COG0500	methyltransferase
Thivi_2014	COG0142	geranyltranstransferase activity
Thivi_2022	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
Thivi_2023	COG1819	glycosyl
Thivi_2024	COG1562	ergosterol biosynthetic process
Thivi_2025	COG1233	COG1233 Phytoene dehydrogenase and related
Thivi_2026	COG1397	ADP-ribosylglycohydrolase
Thivi_2027	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
Thivi_2028	COG1074	ATP-dependent DNA helicase activity
Thivi_2029	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
Thivi_2031	COG0513	Belongs to the DEAD box helicase family
Thivi_2032	COG2226	methyltransferase
Thivi_2037	COG0631	protein serine/threonine phosphatase activity
Thivi_2047	COG5433	transposase activity
Thivi_2049	COG2815	serine threonine protein kinase
Thivi_2049	COG0515	serine threonine protein kinase
Thivi_2054	COG0631	protein serine/threonine phosphatase activity
Thivi_2067	COG1943	Transposase
Thivi_2069	COG0714	Associated with various cellular activities
Thivi_2072	COG1490	D-aminoacyl-tRNA deacylase activity
Thivi_2079	COG0215	cysteine-tRNA ligase activity
Thivi_2080	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
Thivi_2081	COG0830	nickel cation binding
Thivi_2082	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
Thivi_2083	COG0804	urea catabolic process
Thivi_2084	COG0832	Belongs to the urease beta subunit family
Thivi_2085	COG0831	urea catabolic process
Thivi_2086	COG0829	nickel cation binding
Thivi_2089	COG0411	ABC transporter
Thivi_2091	COG0559	Belongs to the binding-protein-dependent transport system permease family
Thivi_2094	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
Thivi_2094	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
Thivi_2100	COG0840	transmembrane signaling receptor activity
Thivi_2101	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
Thivi_2101	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
Thivi_2103	COG1519	Transferase
Thivi_2107	COG0745	RESPONSE REGULATOR receiver
Thivi_2108	COG5002	protein histidine kinase activity
Thivi_2110	COG4251	negative regulation of phosphorylation
Thivi_2113	COG0058	SHG alpha-glucan phosphorylase activity
Thivi_2114	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
Thivi_2115	COG4636	protein conserved in cyanobacteria
Thivi_2116	COG0514	ATP-dependent DNA helicase (RecQ)
Thivi_2121	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
Thivi_2122	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
Thivi_2123	COG1605	Chorismate mutase
Thivi_2123	COG0077	Prephenate dehydratase
Thivi_2124	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
Thivi_2125	COG0287	Prephenate dehydrogenase
Thivi_2126	COG0704	Plays a role in the regulation of phosphate uptake
Thivi_2130	COG0426	domain, Protein
Thivi_2146	COG0028	Belongs to the TPP enzyme family
Thivi_2148	COG4251	negative regulation of phosphorylation
Thivi_2149	COG0784	Response regulator, receiver
Thivi_2151	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
Thivi_2155	COG0583	DNA-binding transcription factor activity
Thivi_2157	COG2824	Alkylphosphonate utilization operon protein PhnA
Thivi_2159	COG2210	Belongs to the sulfur carrier protein TusA family
Thivi_2160	COG0425	Belongs to the sulfur carrier protein TusA family
Thivi_2161	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
Thivi_2162	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
Thivi_2162	COG1648	precorrin-2 dehydrogenase activity
Thivi_2163	COG0741	lytic transglycosylase activity
Thivi_2173	COG1358	cellular component organization or biogenesis
Thivi_2177	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
Thivi_2179	COG1652	LysM domain
Thivi_2179	COG2823	Periplasmic or secreted lipoprotein
Thivi_2186	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
Thivi_2188	COG0616	signal peptide processing
Thivi_2189	COG0546	phosphoglycolate phosphatase activity
Thivi_2191	COG1530	ribonuclease E activity
Thivi_2195	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
Thivi_2208	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
Thivi_2214	COG0569	domain protein
Thivi_2214	COG0189	ligase activity
Thivi_2218	COG2321	neutral zinc metallopeptidase
Thivi_2221	COG0165	Argininosuccinate lyase
Thivi_2224	COG0561	phosphatase activity
Thivi_2227	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
Thivi_2228	COG1881	PFAM PEBP family protein
Thivi_2230	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
Thivi_2233	COG1137	ATPase activity
Thivi_2238	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
Thivi_2239	COG1660	Displays ATPase and GTPase activities
Thivi_2241	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
Thivi_2242	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
Thivi_2243	COG2239	Acts as a magnesium transporter
Thivi_2249	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
Thivi_2250	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
Thivi_2254	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
Thivi_2257	COG0463	Glycosyl transferase, family 2
Thivi_2263	COG1570	exodeoxyribonuclease VII activity
Thivi_2265	COG0517	IMP dehydrogenase activity
Thivi_2265	COG0516	GMP reductase activity
Thivi_2268	COG0518	GMP synthase (glutamine-hydrolyzing) activity
Thivi_2268	COG0519	Catalyzes the synthesis of GMP from XMP
Thivi_2274	COG1902	pentaerythritol trinitrate reductase activity
Thivi_2275	COG0590	tRNA wobble adenosine to inosine editing
Thivi_2276	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
Thivi_2280	COG3263	regulation of cellular component size
Thivi_2281	COG3123	guanosine phosphorylase activity
Thivi_2297	COG3501	Rhs element vgr protein
Thivi_2301	COG1360	Flagellar Motor Protein
Thivi_2307	COG0494	nUDIX hydrolase
Thivi_2308	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
Thivi_2309	COG0653	protein targeting
Thivi_2312	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
Thivi_2315	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
Thivi_2316	COG1181	Belongs to the D-alanine--D-alanine ligase family
Thivi_2317	COG0812	UDP-N-acetylmuramate dehydrogenase activity
Thivi_2318	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
Thivi_2319	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
Thivi_2320	COG0772	Belongs to the SEDS family
Thivi_2321	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
Thivi_2322	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
Thivi_2323	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
Thivi_2325	COG3116	cell division
Thivi_2326	COG0275	rRNA processing
Thivi_2327	COG2001	Belongs to the MraZ family
Thivi_2329	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
Thivi_2330	COG3107	peptidoglycan biosynthetic process
Thivi_2331	COG0792	nuclease activity
Thivi_2332	COG2823	Periplasmic or secreted lipoprotein
Thivi_2333	COG0277	FAD linked oxidase domain protein
Thivi_2340	COG4251	negative regulation of phosphorylation
Thivi_2344	COG0126	phosphoglycerate kinase activity
Thivi_2347	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
Thivi_2348	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
Thivi_2350	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
Thivi_2355	COG0840	transmembrane signaling receptor activity
Thivi_2359	COG4251	negative regulation of phosphorylation
Thivi_2362	COG0582	viral genome integration into host DNA
Thivi_2378	COG3437	response regulator, receiver
Thivi_2379	COG0784	Response regulator, receiver
Thivi_2379	COG2198	Histidine kinase
Thivi_2379	COG2205	protein histidine kinase activity
Thivi_2380	COG4251	negative regulation of phosphorylation
Thivi_2381	COG1598	PFAM Uncharacterised protein family UPF0150
Thivi_2382	COG1724	mRNA binding
Thivi_2386	COG0019	diaminopimelate decarboxylase activity
Thivi_2388	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
Thivi_2390	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
Thivi_2394	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
Thivi_2396	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
Thivi_2398	COG0318	PFAM AMP-dependent synthetase and ligase
Thivi_2399	COG1719	4-vinyl reductase, 4VR
Thivi_2400	COG0635	Involved in the biosynthesis of porphyrin-containing compound
Thivi_2407	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
Thivi_2408	COG1429	ligase activity, forming nitrogen-metal bonds
Thivi_2409	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
Thivi_2410	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
Thivi_2413	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
Thivi_2414	COG0644	oxidoreductase
Thivi_2415	COG1643	Atp-dependent helicase
Thivi_2423	COG1484	DNA-dependent DNA replication
Thivi_2430	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
Thivi_2434	COG0768	penicillin binding
Thivi_2435	COG1441	menaquinone biosynthetic process
Thivi_2438	COG3267	Type II secretory pathway component ExeA
Thivi_2438	COG3409	Peptidoglycan-binding domain 1 protein
Thivi_2440	COG2239	Acts as a magnesium transporter
Thivi_2441	COG2205	protein histidine kinase activity
Thivi_2441	COG2202	Pas domain
Thivi_2442	COG2204	response regulator
Thivi_2443	COG0840	transmembrane signaling receptor activity
Thivi_2447	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
Thivi_2449	COG1262	PFAM Formylglycine-generating sulfatase enzyme
Thivi_2453	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
Thivi_2457	COG1842	Phage shock protein A
Thivi_2460	COG3706	GGDEF domain
Thivi_2464	COG5265	(ABC) transporter
Thivi_2465	COG3850	Histidine kinase
Thivi_2466	COG2197	response regulator
Thivi_2471	COG2814	Major facilitator Superfamily
Thivi_2472	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
Thivi_2475	COG1674	ftsk spoiiie
Thivi_2480	COG0438	transferase activity, transferring glycosyl groups
Thivi_2481	COG0438	transferase activity, transferring glycosyl groups
Thivi_2485	COG4969	Belongs to the N-Me-Phe pilin family
Thivi_2490	COG2801	Transposase and inactivated derivatives
Thivi_2493	COG2337	Toxic component of a toxin-antitoxin (TA) module
Thivi_2497	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
Thivi_2498	COG0511	ligase activity, forming carbon-carbon bonds
Thivi_2498	COG5016	pyruvate
Thivi_2500	COG4953	penicillin-binding protein 1C
Thivi_2501	COG4771	TonB-dependent receptor
Thivi_2504	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
Thivi_2506	COG0513	Belongs to the DEAD box helicase family
Thivi_2507	COG1011	Hydrolase
Thivi_2508	COG0494	nUDIX hydrolase
Thivi_2510	COG0281	malic enzyme
Thivi_2511	COG4536	flavin adenine dinucleotide binding
Thivi_2512	COG2974	May be involved in recombination
Thivi_2514	COG1070	Carbohydrate kinase
Thivi_2517	COG1121	(ABC) transporter
Thivi_2518	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
Thivi_2521	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
Thivi_2527	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
Thivi_2529	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
Thivi_2530	COG4095	Psort location CytoplasmicMembrane, score
Thivi_2531	COG0140	phosphoribosyl-ATP diphosphatase activity
Thivi_2532	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
Thivi_2533	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
Thivi_2534	COG0131	Imidazoleglycerol-phosphate dehydratase
Thivi_2539	COG0280	phosphate acetyltransferase
Thivi_2539	COG0281	malic enzyme
Thivi_2540	COG0569	domain protein
Thivi_2541	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
Thivi_2543	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
Thivi_2545	COG0261	This protein binds to 23S rRNA in the presence of protein L20
Thivi_2546	COG0142	geranyltranstransferase activity
Thivi_2556	COG3459	Glycosyltransferase 36 associated
Thivi_2557	COG2823	Periplasmic or secreted lipoprotein
Thivi_2558	COG2823	Periplasmic or secreted lipoprotein
Thivi_2566	COG0840	transmembrane signaling receptor activity
Thivi_2585	COG1131	(ABC) transporter
Thivi_2586	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
Thivi_2587	COG0303	'Molybdopterin
Thivi_2588	COG0521	Mo-molybdopterin cofactor biosynthetic process
Thivi_2589	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
Thivi_2590	COG1047	Peptidyl-prolyl cis-trans
Thivi_2591	COG0355	proton-transporting ATP synthase activity, rotational mechanism
Thivi_2592	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
Thivi_2593	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
Thivi_2594	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
Thivi_2595	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
Thivi_2596	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
Thivi_2598	COG0356	it plays a direct role in the translocation of protons across the membrane
Thivi_2600	COG1475	DNA binding
Thivi_2601	COG1192	Involved in chromosome partitioning
Thivi_2602	COG0357	Ribosomal RNA small subunit methyltransferase G
Thivi_2603	COG0445	tRNA wobble uridine modification
Thivi_2604	COG0714	Associated with various cellular activities
Thivi_2605	COG0784	Response regulator, receiver
Thivi_2605	COG5002	protein histidine kinase activity
Thivi_2607	COG0436	Aminotransferase
Thivi_2609	COG2171	N-acyltransferase activity
Thivi_2610	COG1393	Belongs to the ArsC family
Thivi_2611	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
Thivi_2615	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
Thivi_2622	COG1131	(ABC) transporter
Thivi_2623	COG0842	Transport permease protein
Thivi_2628	COG0012	GTP binding
Thivi_2630	COG0483	inositol monophosphate 1-phosphatase activity
Thivi_2666	COG0137	argininosuccinate synthase activity
Thivi_2679	COG1216	Glycosyl transferase, family 2
Thivi_2679	COG0438	transferase activity, transferring glycosyl groups
Thivi_2683	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
Thivi_2683	COG2755	lipolytic protein G-D-S-L family
Thivi_2684	COG0438	transferase activity, transferring glycosyl groups
Thivi_2684	COG1216	Glycosyl transferase, family 2
Thivi_2685	COG1215	transferase activity, transferring glycosyl groups
Thivi_2686	COG0702	epimerase
Thivi_2691	COG0375	protein maturation
Thivi_2693	COG1166	arginine decarboxylase activity
Thivi_2695	COG2920	part of a sulfur-relay system
Thivi_2699	COG2181	nitrate reductase activity
Thivi_2705	COG2223	nitrite transmembrane transporter activity
Thivi_2707	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
Thivi_2708	COG2894	cell division
Thivi_2709	COG0850	regulation of cytokinetic process
Thivi_2710	COG0537	adenosine 5'-monophosphoramidase activity
Thivi_2711	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
Thivi_2712	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
Thivi_2713	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
Thivi_2715	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
Thivi_2716	COG1278	Cold shock
Thivi_2717	COG0756	dUTP diphosphatase activity
Thivi_2718	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
Thivi_2719	COG2003	Belongs to the UPF0758 family
Thivi_2720	COG0433	COG0433 Predicted ATPase
Thivi_2722	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
Thivi_2724	COG1160	GTP binding
Thivi_2726	COG2976	Protein conserved in bacteria
Thivi_2727	COG0124	histidyl-tRNA synthetase
Thivi_2730	COG0820	rRNA (adenine-C2-)-methyltransferase activity
Thivi_2731	COG0105	UTP biosynthetic process
Thivi_2733	COG2010	Cytochrome c
Thivi_2734	COG4231	catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates
Thivi_2737	COG3086	response to oxidative stress
Thivi_2741	COG0446	pyridine nucleotide-disulphide oxidoreductase
Thivi_2743	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
Thivi_2744	COG0024	Methionine aminopeptidase
Thivi_2745	COG0052	Belongs to the universal ribosomal protein uS2 family
Thivi_2746	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
Thivi_2747	COG0528	UMP kinase activity
Thivi_2748	COG0233	cytoplasmic translational termination
Thivi_2749	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
Thivi_2751	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
Thivi_2753	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
Thivi_2755	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
Thivi_2756	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
Thivi_2757	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
Thivi_2759	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
Thivi_2766	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
Thivi_2772	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
Thivi_2776	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
Thivi_2777	COG1053	succinate dehydrogenase
Thivi_2778	COG2009	succinate dehydrogenase
Thivi_2780	COG2001	Belongs to the MraZ family
Thivi_2783	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
Thivi_2784	COG0693	protein deglycase activity
Thivi_2785	COG0793	Belongs to the peptidase S41A family
Thivi_2786	COG4942	peptidase
Thivi_2789	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
Thivi_2790	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
Thivi_2791	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
Thivi_2794	COG2204	response regulator
Thivi_2795	COG3852	Histidine kinase
Thivi_2797	COG0174	glutamine synthetase
Thivi_2800	COG1716	ATPase activity
Thivi_2800	COG1131	(ABC) transporter
Thivi_2800	COG0842	Transport permease protein
Thivi_2801	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
Thivi_2802	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
Thivi_2806	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
Thivi_2812	COG3344	reverse transcriptase
Thivi_2826	COG1058	Belongs to the CinA family
Thivi_2826	COG1546	Belongs to the CinA family
Thivi_2828	COG1459	type II secretion system
Thivi_2831	COG0751	glycine-tRNA ligase activity
Thivi_2832	COG0752	glycyl-tRNA synthetase alpha subunit
Thivi_2833	COG3045	CreA protein
Thivi_2843	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
Thivi_2845	COG0210	DNA helicase
Thivi_2846	COG0539	negative regulation of cytoplasmic translation
Thivi_2847	COG0635	Involved in the biosynthesis of porphyrin-containing compound
Thivi_2848	COG0254	rRNA binding
Thivi_2850	COG0372	Belongs to the citrate synthase family
Thivi_2858	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
Thivi_2859	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
Thivi_2860	COG0070	glutamate synthase
Thivi_2860	COG0069	glutamate synthase activity
Thivi_2860	COG0067	glutamate synthase
Thivi_2865	COG1450	Type ii and iii secretion system protein
Thivi_2868	COG3166	PFAM Fimbrial assembly family protein
Thivi_2869	COG3156	type II secretion system protein K
Thivi_2871	COG2165	general secretion pathway protein
Thivi_2876	COG3153	acetyltransferase
Thivi_2891	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
Thivi_2894	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
Thivi_2895	COG0390	transport system, permease component
Thivi_2896	COG3842	ATPase activity
Thivi_2897	COG0220	tRNA (guanine-N7-)-methyltransferase activity
Thivi_2898	COG2022	thiamine diphosphate biosynthetic process
Thivi_2900	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
Thivi_2901	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
Thivi_2904	COG0314	molybdopterin synthase activity
Thivi_2905	COG0187	DNA topoisomerase II activity
Thivi_2908	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
Thivi_2909	COG0649	NAD binding
Thivi_2910	COG0651	ATP synthesis coupled electron transport
Thivi_2912	COG0650	Formate hydrogenlyase subunit 4
Thivi_2913	COG0651	ATP synthesis coupled electron transport
Thivi_2917	COG0560	Phosphoserine phosphatase
Thivi_2921	COG4245	von Willebrand factor, type A
Thivi_2957	COG1320	monovalent cation:proton antiporter activity
Thivi_2958	COG2212	antiporter activity
Thivi_2960	COG0651	ATP synthesis coupled electron transport
Thivi_2961	COG1006	Multisubunit Na H antiporter MnhC subunit
Thivi_2962	COG2111	Na H antiporter
Thivi_2962	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
Thivi_2966	COG5433	transposase activity
Thivi_2970	COG1376	ErfK ybiS ycfS ynhG family protein
Thivi_2971	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
Thivi_2972	COG3706	GGDEF domain
Thivi_2976	COG1999	signal sequence binding
Thivi_2984	COG2177	Part of the ABC transporter FtsEX involved in
Thivi_2985	COG2884	Cell division ATP-binding protein ftsE
Thivi_2986	COG0552	protein localization to endoplasmic reticulum
Thivi_2990	COG1253	flavin adenine dinucleotide binding
Thivi_2991	COG1215	transferase activity, transferring glycosyl groups
Thivi_2994	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
Thivi_2995	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
Thivi_2997	COG0742	ribosomal rna small subunit methyltransferase
Thivi_2998	COG0612	Peptidase, M16
Thivi_2999	COG0612	Peptidase, M16
Thivi_3000	COG0745	RESPONSE REGULATOR receiver
Thivi_3000	COG2205	protein histidine kinase activity
Thivi_3000	COG4191	Histidine kinase
Thivi_3002	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
Thivi_3003	COG0167	dihydroorotate dehydrogenase activity
Thivi_3005	COG0594	ribonuclease P activity
Thivi_3006	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
Thivi_3007	COG0706	membrane insertase activity
Thivi_3008	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
Thivi_3013	COG5433	transposase activity
Thivi_3031	COG1741	Belongs to the pirin family
Thivi_3032	COG1028	Short-chain dehydrogenase reductase Sdr
Thivi_3037	COG0471	metal ion transport
Thivi_3037	COG3273	potassium ion transport
Thivi_3039	COG5001	Diguanylate cyclase
Thivi_3039	COG3300	MHYT domain
Thivi_3040	COG0717	Belongs to the dCTP deaminase family
Thivi_3043	COG0438	transferase activity, transferring glycosyl groups
Thivi_3046	COG0573	inorganic phosphate transmembrane transporter activity
Thivi_3048	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
Thivi_3052	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
Thivi_3053	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
Thivi_3053	COG0574	Belongs to the PEP-utilizing enzyme family
Thivi_3055	COG1215	transferase activity, transferring glycosyl groups
Thivi_3059	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
Thivi_3063	COG4133	protoheme IX ABC transporter activity
Thivi_3065	COG3088	subunit of a heme lyase
Thivi_3065	COG4235	cytochrome complex assembly
Thivi_3066	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
Thivi_3068	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
Thivi_3069	COG2135	peptidase activity
Thivi_3072	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
Thivi_3076	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
Thivi_3077	COG0352	thiamine-phosphate diphosphorylase activity
Thivi_3078	COG0351	phosphomethylpyrimidine kinase
Thivi_3079	COG1773	rubredoxin
Thivi_3082	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
Thivi_3083	COG0316	Belongs to the HesB IscA family
Thivi_3085	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
Thivi_3087	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
Thivi_3088	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
Thivi_3109	COG0419	ATPase involved in DNA repair
Thivi_3111	COG2048	Heterodisulfide reductase, subunit B
Thivi_3114	COG1233	COG1233 Phytoene dehydrogenase and related
Thivi_3115	COG1793	dna ligase
Thivi_3116	COG0500	methyltransferase
Thivi_3120	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
Thivi_3121	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
Thivi_3122	COG3959	Transketolase, thiamine diphosphate binding domain
Thivi_3123	COG3958	Transketolase
Thivi_3125	COG1850	ribulose-bisphosphate carboxylase activity
Thivi_3126	COG1862	Preprotein translocase
Thivi_3127	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
Thivi_3128	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
Thivi_3132	COG4181	ATPase activity
Thivi_3133	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
Thivi_3136	COG3864	Putative metallopeptidase domain
Thivi_3137	COG4783	chaperone-mediated protein folding
Thivi_3148	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
Thivi_3150	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
Thivi_3155	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
Thivi_3156	COG1169	isochorismate synthase
Thivi_3158	COG0702	epimerase
Thivi_3161	COG1472	Belongs to the glycosyl hydrolase 3 family
Thivi_3166	COG0779	Required for maturation of 30S ribosomal subunits
Thivi_3167	COG0195	Participates in both transcription termination and antitermination
Thivi_3168	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
Thivi_3169	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
Thivi_3170	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
Thivi_3171	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
Thivi_3172	COG1185	polyribonucleotide nucleotidyltransferase activity
Thivi_3173	COG1177	transmembrane transport
Thivi_3174	COG1176	ABC-type spermidine putrescine transport system, permease component I
Thivi_3175	COG3842	ATPase activity
Thivi_3176	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
Thivi_3179	COG2878	Part of a membrane complex involved in electron transport
Thivi_3179	COG1148	4fe-4S ferredoxin, iron-sulfur binding domain protein
Thivi_3181	COG4656	Part of a membrane complex involved in electron transport
Thivi_3182	COG4658	electron transport chain
Thivi_3183	COG4659	FMN binding
Thivi_3184	COG4660	Part of a membrane complex involved in electron transport
Thivi_3185	COG4657	Part of a membrane complex involved in electron transport
Thivi_3187	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
Thivi_3188	COG0488	(ABC) transporter
Thivi_3191	COG1763	Mo-molybdopterin cofactor biosynthetic process
Thivi_3192	COG0569	domain protein
Thivi_3193	COG2204	response regulator
Thivi_3194	COG5000	phosphorelay sensor kinase activity
Thivi_3197	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
Thivi_3198	COG0242	peptide deformylase activity
Thivi_3200	COG0758	DNA mediated transformation
Thivi_3201	COG2922	Belongs to the Smg family
Thivi_3204	COG0009	L-threonylcarbamoyladenylate synthase
Thivi_3205	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
Thivi_3213	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
Thivi_3214	COG3273	potassium ion transport
Thivi_3214	COG0471	metal ion transport
Thivi_3219	COG0189	ligase activity
Thivi_3220	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
Thivi_3223	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
Thivi_3225	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
Thivi_3226	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
Thivi_3228	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
Thivi_3229	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
Thivi_3232	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
Thivi_3233	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
Thivi_3234	COG1127	ABC transporter
Thivi_3235	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
Thivi_3239	COG1802	Transcriptional regulator
Thivi_3250	COG3706	GGDEF domain
Thivi_3251	COG4251	negative regulation of phosphorylation
Thivi_3253	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
Thivi_3257	COG3527	Alpha-acetolactate decarboxylase
Thivi_3263	COG1108	ABC-type Mn2 Zn2 transport systems permease components
Thivi_3264	COG0735	belongs to the Fur family
Thivi_3267	COG1028	Short-chain dehydrogenase reductase Sdr
Thivi_3270	COG0227	Belongs to the bacterial ribosomal protein bL28 family
Thivi_3271	COG0267	Belongs to the bacterial ribosomal protein bL33 family
Thivi_3276	COG0297	glycogen (starch) synthase activity
Thivi_3277	COG0443	Heat shock 70 kDa protein
Thivi_3282	COG1262	PFAM Formylglycine-generating sulfatase enzyme
Thivi_3285	COG0316	Belongs to the HesB IscA family
Thivi_3286	COG2166	iron-sulfur cluster assembly
Thivi_3288	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
Thivi_3292	COG4589	Belongs to the CDS family
Thivi_3301	COG2363	Small membrane protein
Thivi_3302	COG1385	rRNA (uridine-N3-)-methyltransferase activity
Thivi_3304	COG0840	transmembrane signaling receptor activity
Thivi_3308	COG0189	ligase activity
Thivi_3311	COG1678	Uncharacterized ACR, COG1678
Thivi_3312	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
Thivi_3314	COG0540	Belongs to the ATCase OTCase family
Thivi_3319	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
Thivi_3320	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
Thivi_3322	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
Thivi_3324	COG0194	GDP metabolic process
Thivi_3325	COG1561	YicC-like family, N-terminal region
Thivi_3326	COG0515	serine threonine protein kinase
Thivi_3326	COG3266	domain, Protein
Thivi_3327	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
Thivi_3328	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
Thivi_3332	COG1872	DUF167
Thivi_3334	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
Thivi_3336	COG3562	capsule polysaccharide
Thivi_3342	COG0402	S-adenosylhomocysteine deaminase activity
Thivi_3343	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
Thivi_3345	COG0196	riboflavin kinase activity
Thivi_3347	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
Thivi_3349	COG1199	ATP-dependent helicase activity
Thivi_3350	COG0450	alkyl hydroperoxide reductase
Thivi_3351	COG1643	Atp-dependent helicase
Thivi_3353	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
Thivi_3353	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
Thivi_3357	COG0045	succinate-CoA ligase (ADP-forming) activity
Thivi_3358	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
Thivi_3360	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
Thivi_3360	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
Thivi_3365	COG3830	Belongs to the UPF0237 family
Thivi_3366	COG0242	peptide deformylase activity
Thivi_3367	COG0793	Belongs to the peptidase S41A family
Thivi_3368	COG2918	glutathione biosynthetic process
Thivi_3370	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
Thivi_3372	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
Thivi_3373	COG0741	lytic transglycosylase activity
Thivi_3377	COG0218	Necessary for normal cell division and for the maintenance of normal septation
Thivi_3378	COG0315	cyclic pyranopterin monophosphate synthase activity
Thivi_3379	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
Thivi_3381	COG0205	6-phosphofructokinase activity
Thivi_3383	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
Thivi_3384	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
Thivi_3385	COG0006	proline dipeptidase activity
Thivi_3386	COG3079	Belongs to the UPF0149 family
Thivi_3390	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
Thivi_3391	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
Thivi_3394	COG4657	Part of a membrane complex involved in electron transport
Thivi_3397	COG4658	electron transport chain
Thivi_3400	COG2914	Belongs to the UPF0125 (RnfH) family
Thivi_3401	COG1403	HNH endonuclease
Thivi_3402	COG0116	Belongs to the methyltransferase superfamily
Thivi_3402	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
Thivi_3404	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
Thivi_3405	COG0205	6-phosphofructokinase activity
Thivi_3406	COG0508	dehydrogenase complex catalyzes the overall conversion of
Thivi_3416	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
Thivi_3417	COG2816	NAD+ diphosphatase activity
Thivi_3422	COG0515	serine threonine protein kinase
Thivi_3422	COG2815	serine threonine protein kinase
Thivi_3426	COG1262	PFAM Formylglycine-generating sulfatase enzyme
Thivi_3428	COG1716	ATPase activity
Thivi_3434	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
Thivi_3435	COG1028	Short-chain dehydrogenase reductase Sdr
Thivi_3441	COG3243	poly(R)-hydroxyalkanoic acid synthase
Thivi_3445	COG0811	peptide transport
Thivi_3446	COG0848	biopolymer transport protein
Thivi_3447	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
Thivi_3451	COG4149	molybdate abc transporter
Thivi_3452	COG3842	ATPase activity
Thivi_3461	COG3706	GGDEF domain
Thivi_3461	COG0745	RESPONSE REGULATOR receiver
Thivi_3462	COG0058	SHG alpha-glucan phosphorylase activity
Thivi_3465	COG0488	(ABC) transporter
Thivi_3466	COG0606	chelatase, subunit chli
Thivi_3467	COG2960	long-chain fatty acid transporting porin activity
Thivi_3469	COG0347	Belongs to the P(II) protein family
Thivi_3470	COG0004	ammonium transporteR
Thivi_3471	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
Thivi_3474	COG0408	coproporphyrinogen oxidase activity
Thivi_3476	COG0667	Aldo Keto reductase
Thivi_3477	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
Thivi_3478	COG0546	phosphoglycolate phosphatase activity
Thivi_3484	COG1301	dicarboxylic acid transport
Thivi_3487	COG2207	Transcriptional regulator
Thivi_3492	COG2863	cytochrome
Thivi_3494	COG0525	valine-tRNA ligase activity
Thivi_3495	COG4804	nuclease activity
Thivi_3519	COG4373	Mu-like prophage FluMu protein gp28
Thivi_3528	COG5005	Phage virion morphogenesis
Thivi_3542	COG0739	heme binding
Thivi_3542	COG0741	lytic transglycosylase activity
Thivi_3542	COG1196	nuclear chromosome segregation
Thivi_3547	COG5433	transposase activity
Thivi_3552	COG5433	transposase activity
Thivi_3554	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
Thivi_3555	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
Thivi_3557	COG3038	cytochrome b561
Thivi_3558	COG0598	Magnesium transport protein CorA
Thivi_3567	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
Thivi_3570	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
Thivi_3571	COG2226	methyltransferase
Thivi_3572	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
Thivi_3574	COG0248	Ppx GppA phosphatase
Thivi_3576	COG3264	Mechanosensitive ion channel
Thivi_3576	COG1511	domain protein
Thivi_3579	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
Thivi_3583	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
Thivi_3585	COG5433	transposase activity
Thivi_3591	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
Thivi_3592	COG0134	indole-3-glycerol-phosphate synthase activity
Thivi_3594	COG1765	OsmC-like protein
Thivi_3595	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
Thivi_3596	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
Thivi_3597	COG0247	lactate metabolic process
Thivi_3599	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
Thivi_3603	COG2801	Transposase and inactivated derivatives
Thivi_3605	COG0513	Belongs to the DEAD box helicase family
Thivi_3607	COG5433	transposase activity
Thivi_3614	COG0815	Transfers the fatty acyl group on membrane lipoproteins
Thivi_3616	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
Thivi_3619	COG0204	Acyl-transferase
Thivi_3619	COG0318	PFAM AMP-dependent synthetase and ligase
Thivi_3621	COG0494	nUDIX hydrolase
Thivi_3622	COG3605	phosphoenolpyruvate-protein phosphotransferase activity
Thivi_3625	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
Thivi_3644	COG0582	viral genome integration into host DNA
Thivi_3647	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
Thivi_3657	COG0058	SHG alpha-glucan phosphorylase activity
Thivi_3659	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
Thivi_3660	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
Thivi_3661	COG0628	permease
Thivi_3675	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
Thivi_3676	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
Thivi_3679	COG0438	transferase activity, transferring glycosyl groups
Thivi_3683	COG0551	DNA topoisomerase type I activity
Thivi_3683	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
Thivi_3687	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
Thivi_3690	COG0784	Response regulator, receiver
Thivi_3690	COG2205	protein histidine kinase activity
Thivi_3690	COG2198	Histidine kinase
Thivi_3692	COG0745	RESPONSE REGULATOR receiver
Thivi_3695	COG2813	Specifically methylates the guanine in position
Thivi_3696	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
Thivi_3697	COG0298	carbon dioxide binding
Thivi_3703	COG0583	DNA-binding transcription factor activity
Thivi_3708	COG0586	Pfam SNARE associated Golgi protein
Thivi_3714	COG5433	transposase activity
Thivi_3717	COG5433	transposase activity
Thivi_3718	COG2197	response regulator
Thivi_3723	COG4974	Belongs to the 'phage' integrase family
Thivi_3724	COG1666	GTP binding
Thivi_3725	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
Thivi_3726	COG0631	protein serine/threonine phosphatase activity
Thivi_3735	COG5433	transposase activity
Thivi_3738	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
Thivi_3739	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
Thivi_3739	COG2885	chlorophyll binding
Thivi_3743	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
Thivi_3744	COG0723	plastoquinol--plastocyanin reductase activity
Thivi_3745	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
Thivi_3746	COG2857	Cytochrome c1
Thivi_3747	COG0625	glutathione transferase activity
Thivi_3748	COG2969	positive regulation of protein catabolic process
Thivi_3750	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
Thivi_3753	COG1022	Amp-dependent synthetase and ligase
Thivi_3755	COG0513	Belongs to the DEAD box helicase family
Thivi_3760	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
Thivi_3764	COG1523	belongs to the glycosyl hydrolase 13 family
Thivi_3766	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
Thivi_3770	COG2205	protein histidine kinase activity
Thivi_3770	COG0784	Response regulator, receiver
Thivi_3770	COG5002	protein histidine kinase activity
Thivi_3771	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
Thivi_3772	COG1573	uracil-dna glycosylase
Thivi_3779	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
Thivi_3783	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
Thivi_3786	COG0737	Belongs to the 5'-nucleotidase family
Thivi_3789	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
Thivi_3791	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
Thivi_3794	COG0018	arginyl-trna synthetase
Thivi_3795	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
Thivi_3805	COG0811	peptide transport
Thivi_3806	COG0848	biopolymer transport protein
Thivi_3807	COG1132	(ABC) transporter
Thivi_3808	COG1663	tetraacyldisaccharide 4'-kinase activity
Thivi_3809	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
Thivi_3810	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
Thivi_3811	COG3162	membrane
Thivi_3812	COG0167	dihydroorotate dehydrogenase activity
Thivi_3813	COG1013	pyruvate-flavodoxin oxidoreductase activity
Thivi_3813	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
Thivi_3813	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
Thivi_3813	COG0674	pyruvate-flavodoxin oxidoreductase activity
Thivi_3814	COG0456	acetyltransferase
Thivi_3818	COG1151	hydroxylamine reductase activity
Thivi_3821	COG2133	pyrroloquinoline quinone binding
Thivi_3824	COG0154	amidase activity
Thivi_3825	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
Thivi_3826	COG1077	Cell shape determining protein MreB Mrl
Thivi_3827	COG1792	Involved in formation and maintenance of cell shape
Thivi_3829	COG0768	penicillin binding
Thivi_3830	COG0772	Belongs to the SEDS family
Thivi_3831	COG2951	lytic endotransglycosylase activity
Thivi_3833	COG1686	Belongs to the peptidase S11 family
Thivi_3834	COG2921	Belongs to the UPF0250 family
Thivi_3835	COG0321	lipoyl(octanoyl) transferase activity
Thivi_3840	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
Thivi_3842	COG0343	queuine tRNA-ribosyltransferase activity
Thivi_3843	COG0071	Belongs to the small heat shock protein (HSP20) family
Thivi_3844	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
Thivi_3847	COG0037	tRNA processing
Thivi_3855	COG0567	Dehydrogenase, E1 component
Thivi_3859	COG2205	protein histidine kinase activity
Thivi_3860	COG0745	RESPONSE REGULATOR receiver
Thivi_3864	COG0339	signal peptide processing
Thivi_3866	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
Thivi_3867	COG0724	RNA recognition motif
Thivi_3870	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
Thivi_3871	COG0543	2 iron, 2 sulfur cluster binding
Thivi_3871	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
Thivi_3883	COG1587	Uroporphyrinogen-III synthase
Thivi_3884	COG0181	hydroxymethylbilane synthase activity
Thivi_3891	COG5433	transposase activity
Thivi_3898	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
Thivi_3899	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
Thivi_3900	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
Thivi_3902	COG1752	Esterase of the alpha-beta hydrolase superfamily
Thivi_3908	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
Thivi_3909	COG0149	triose-phosphate isomerase activity
Thivi_3912	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
Thivi_3913	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
Thivi_3914	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
Thivi_3915	COG0649	NAD binding
Thivi_3916	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
Thivi_3918	COG1034	ATP synthesis coupled electron transport
Thivi_3918	COG1034	ATP synthesis coupled electron transport
Thivi_3919	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
Thivi_3920	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
Thivi_3922	COG0713	ATP synthesis coupled electron transport
Thivi_3925	COG1007	ATP synthesis coupled electron transport
Thivi_3926	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
Thivi_3927	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
Thivi_3928	COG3706	GGDEF domain
Thivi_3928	COG0745	RESPONSE REGULATOR receiver
Thivi_3934	COG4117	Thiosulfate reductase cytochrome B subunit (Membrane anchoring protein)
Thivi_3936	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
Thivi_3937	COG0437	4 iron, 4 sulfur cluster binding
Thivi_3938	COG5557	Pfam Polysulphide reductase, NrfD
Thivi_3939	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
Thivi_3940	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
Thivi_3948	COG2204	response regulator
Thivi_3954	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
Thivi_3963	COG3034	peptidoglycan biosynthetic process
Thivi_3964	COG0741	lytic transglycosylase activity
Thivi_3964	COG1388	LysM domain
Thivi_3966	COG0328	RNA-DNA hybrid ribonuclease activity
Thivi_3967	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
Thivi_3968	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
Thivi_3969	COG0504	CTP synthase activity
Thivi_3970	COG2877	3-deoxy-8-phosphooctulonate synthase activity
Thivi_3975	COG0148	phosphopyruvate hydratase activity
Thivi_3976	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
Thivi_3977	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
Thivi_3983	COG0529	Catalyzes the synthesis of activated sulfate
Thivi_3984	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
Thivi_3988	COG1269	ATP hydrolysis coupled proton transport
Thivi_3991	COG3850	Histidine kinase
Thivi_3991	COG4999	Histidine kinase
Thivi_3991	COG3437	response regulator, receiver
Thivi_3991	COG2205	protein histidine kinase activity
Thivi_3993	COG3258	Cytochrome c
Thivi_3994	COG0259	pyridoxamine-phosphate oxidase activity
Thivi_3995	COG2224	Isocitrate lyase
Thivi_3996	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
Thivi_3997	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
Thivi_3998	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
Thivi_3998	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
Thivi_3999	COG0802	atpase or kinase
Thivi_4000	COG0860	N-Acetylmuramoyl-L-alanine amidase
Thivi_4001	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
Thivi_4002	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
Thivi_4003	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
Thivi_4008	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
Thivi_4010	COG0142	geranyltranstransferase activity
Thivi_4012	COG2076	Multidrug Resistance protein
Thivi_4013	COG1469	GTP cyclohydrolase I activity
Thivi_4017	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
Thivi_4019	COG4999	Histidine kinase
Thivi_4019	COG3850	Histidine kinase
Thivi_4019	COG3437	response regulator, receiver
Thivi_4019	COG2205	protein histidine kinase activity
Thivi_4032	COG0297	glycogen (starch) synthase activity
Thivi_4046	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
Thivi_4050	COG1216	Glycosyl transferase, family 2
Thivi_4057	COG1216	Glycosyl transferase, family 2
Thivi_4064	COG0438	transferase activity, transferring glycosyl groups
Thivi_4069	COG1162	GTPase activity
Thivi_4071	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
Thivi_4078	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
Thivi_4081	COG0828	Belongs to the bacterial ribosomal protein bS21 family
Thivi_4082	COG1610	YqeY-like protein
Thivi_4084	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
Thivi_4089	COG1752	Esterase of the alpha-beta hydrolase superfamily
Thivi_4094	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
Thivi_4098	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
Thivi_4099	COG0424	maF-like protein
Thivi_4100	COG1530	ribonuclease E activity
Thivi_4102	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
Thivi_4103	COG0312	modulator of DNA gyrase
Thivi_4104	COG1061	Type III restriction enzyme res subunit
Thivi_4107	COG2197	response regulator
Thivi_4108	COG3706	GGDEF domain
Thivi_4114	COG0643	Histidine kinase
Thivi_4114	COG2198	Histidine kinase
Thivi_4116	COG0835	chemotaxis
Thivi_4117	COG0840	transmembrane signaling receptor activity
Thivi_4117	COG0840	transmembrane signaling receptor activity
Thivi_4118	COG0835	chemotaxis
Thivi_4120	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
Thivi_4122	COG5001	Diguanylate cyclase
Thivi_4122	COG3300	MHYT domain
Thivi_4124	COG0312	modulator of DNA gyrase
Thivi_4127	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
Thivi_4128	COG0076	glutamate decarboxylase activity
Thivi_4139	COG0312	modulator of DNA gyrase
Thivi_4144	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
Thivi_4146	COG5001	Diguanylate cyclase
Thivi_4146	COG3300	MHYT domain
Thivi_4147	COG1639	'signal transduction protein
Thivi_4149	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
Thivi_4152	COG2951	lytic endotransglycosylase activity
Thivi_4153	COG0432	Pfam Uncharacterised protein family UPF0047
Thivi_4154	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
Thivi_4155	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
Thivi_4163	COG3437	response regulator, receiver
Thivi_4165	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
Thivi_4173	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
Thivi_4174	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
Thivi_4176	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
Thivi_4178	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
Thivi_4179	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
Thivi_4180	COG0193	aminoacyl-tRNA hydrolase activity
Thivi_4186	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
Thivi_4190	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
Thivi_4191	COG0081	regulation of translation
Thivi_4192	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
Thivi_4193	COG0222	ribosome binding
Thivi_4194	COG0085	RNA polymerase activity
Thivi_4195	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
Thivi_4196	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
Thivi_4197	COG0049	tRNA binding
Thivi_4198	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
Thivi_4199	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
Thivi_4200	COG0051	transcription antitermination factor activity, RNA binding
Thivi_4201	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
Thivi_4203	COG0089	rRNA binding
Thivi_4204	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
Thivi_4205	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
Thivi_4206	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
Thivi_4207	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
Thivi_4208	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
Thivi_4209	COG0255	Belongs to the universal ribosomal protein uL29 family
Thivi_4210	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
Thivi_4211	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
Thivi_4212	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
Thivi_4213	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
Thivi_4214	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
Thivi_4215	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
Thivi_4216	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
Thivi_4217	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
Thivi_4218	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
Thivi_4219	COG1841	ribosomal large subunit assembly
Thivi_4220	COG0200	Binds to the 23S rRNA
Thivi_4221	COG0201	protein transport
Thivi_4222	COG0257	Belongs to the bacterial ribosomal protein bL36 family
Thivi_4223	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
Thivi_4224	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
Thivi_4225	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
Thivi_4226	COG0202	RNA polymerase activity
Thivi_4227	COG0203	ribosomal protein L17
Thivi_4230	COG0322	excinuclease ABC activity
Thivi_4232	COG0617	tRNA 3'-terminal CCA addition
Thivi_4238	COG1850	ribulose-bisphosphate carboxylase activity
Thivi_4239	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
Thivi_4240	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
Thivi_4243	COG0348	domain, Protein
Thivi_4244	COG0437	4 iron, 4 sulfur cluster binding
Thivi_4245	COG0243	molybdopterin cofactor binding
Thivi_4248	COG3850	Histidine kinase
Thivi_4249	COG2197	response regulator
Thivi_4250	COG0367	asparagine synthase
Thivi_4256	COG0489	protein tyrosine kinase activity
Thivi_4258	COG1596	polysaccharide export
Thivi_4259	COG2204	response regulator
Thivi_4261	COG3267	Type II secretory pathway component ExeA
Thivi_4261	COG3409	Peptidoglycan-binding domain 1 protein
Thivi_4271	COG5433	transposase activity
Thivi_4273	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
Thivi_4279	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
Thivi_4283	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
Thivi_4284	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
Thivi_4295	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
Thivi_4296	COG1187	pseudouridine synthase activity
Thivi_4298	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
Thivi_4299	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
Thivi_4301	COG1674	ftsk spoiiie
Thivi_4302	COG1674	ftsk spoiiie
Thivi_4303	COG5002	protein histidine kinase activity
Thivi_4305	COG1278	Cold shock
Thivi_4308	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
Thivi_4311	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
Thivi_4313	COG4636	protein conserved in cyanobacteria
Thivi_4317	COG0228	four-way junction DNA binding
Thivi_4318	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
Thivi_4319	COG0336	Belongs to the RNA methyltransferase TrmD family
Thivi_4320	COG0335	large ribosomal subunit rRNA binding
Thivi_4321	COG2925	Exonuclease
Thivi_4322	COG1720	tRNA m6t6A37 methyltransferase activity
Thivi_4323	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
Thivi_4326	COG1376	ErfK ybiS ycfS ynhG family protein
Thivi_4327	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
Thivi_4328	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
Thivi_4329	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
Thivi_4335	COG0745	RESPONSE REGULATOR receiver
Thivi_4341	COG3077	Addiction module antitoxin, RelB DinJ family
Thivi_4343	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
Thivi_4345	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
Thivi_4347	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
Thivi_4349	COG1053	succinate dehydrogenase
Thivi_4350	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
Thivi_4358	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
Thivi_4361	COG4067	protein conserved in archaea
Thivi_4361	COG0189	ligase activity
Thivi_4365	COG0322	excinuclease ABC activity
Thivi_4379	COG2801	Transposase and inactivated derivatives
Thivi_4401	COG0776	regulation of translation
Thivi_4410	COG3646	Phage regulatory protein
Thivi_4423	COG2369	cell adhesion
Thivi_4449	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
Thivi_4450	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
Thivi_4454	COG3852	Histidine kinase
Thivi_4464	COG0745	RESPONSE REGULATOR receiver
Thivi_4469	COG1017	nitric oxide dioxygenase activity
Thivi_4469	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
Thivi_4474	COG0745	RESPONSE REGULATOR receiver
Thivi_4475	COG2205	protein histidine kinase activity
Thivi_4477	COG1444	tRNA N-acetyltransferase activity
Thivi_4478	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
Thivi_4480	COG0446	pyridine nucleotide-disulphide oxidoreductase
Thivi_4481	COG2863	cytochrome
Thivi_4483	COG3005	denitrification pathway
Thivi_4486	COG0297	glycogen (starch) synthase activity
Thivi_4487	COG1196	nuclear chromosome segregation
Thivi_4489	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
Thivi_4497	COG2723	6-phospho-beta-galactosidase activity
Thivi_4498	COG4178	(ABC) transporter
Thivi_4500	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
Thivi_4505	COG3706	GGDEF domain
Thivi_4510	COG5433	transposase activity
Thivi_4511	COG5433	transposase activity
Thivi_4515	COG4636	protein conserved in cyanobacteria
Thivi_4526	COG3132	Protein of unknown function, DUF480
Thivi_4527	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
Thivi_4529	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
Thivi_4531	COG0243	molybdopterin cofactor binding
Thivi_4532	COG0437	4 iron, 4 sulfur cluster binding
Thivi_4533	COG3302	dmso reductase anchor subunit
Thivi_4543	COG2815	serine threonine protein kinase
Thivi_4543	COG0515	serine threonine protein kinase
Thivi_4544	COG2915	High frequency lysogenization protein hflD homolog
Thivi_4545	COG0482	sulfurtransferase activity
Thivi_4549	COG1355	regulation of microtubule-based process
Thivi_4552	COG0741	lytic transglycosylase activity
Thivi_4554	COG2337	Toxic component of a toxin-antitoxin (TA) module
Thivi_4556	COG0730	response to heat
Thivi_4559	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
Thivi_4560	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
Thivi_4561	COG2226	methyltransferase
Thivi_4567	COG0651	ATP synthesis coupled electron transport
Thivi_4570	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
Thivi_4573	COG1278	Cold shock
Thivi_4574	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
Thivi_4575	COG0542	response to heat
Thivi_4581	COG0837	glucose binding
Thivi_4582	COG2608	mercury ion transmembrane transporter activity
Thivi_4583	COG0729	surface antigen
Thivi_4585	COG1560	Kdo2-lipid A biosynthetic process
Thivi_4590	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
Thivi_4593	COG0497	DNA recombination
Thivi_4594	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
Thivi_4595	COG1420	regulation of RNA biosynthetic process
Thivi_4596	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
Thivi_4597	COG0443	Heat shock 70 kDa protein
Thivi_4598	COG0484	heat shock protein binding
Thivi_4599	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
Thivi_4602	COG1858	cytochrome C peroxidase
Thivi_4605	COG2856	Zn peptidase
Thivi_4611	COG1061	Type III restriction enzyme res subunit
Thivi_4621	COG0582	viral genome integration into host DNA
Thivi_4622	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
Thivi_4623	COG0424	maF-like protein
Thivi_4625	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
Thivi_4630	COG0420	3'-5' exonuclease activity
Thivi_4631	COG4717	serine-type aminopeptidase activity