locus-tag	class	description
Thimo_0001	ENOG4105VAS	Could be involved in insertion of integral membrane proteins into the membrane (By similarity)
Thimo_0002	ENOG4105NVJ	RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity)
Thimo_0003	ENOG4105CI4	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity)
Thimo_0004	ENOG4105CZ8	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity)
Thimo_0005	ENOG4105CCT	upf0313 protein
Thimo_0007	ENOG41067HS	methyltransferase
Thimo_0013	ENOG4105KHS	type IV fimbrial pilin protein
Thimo_0015	ENOG41076QQ	Glycosyl transferase, family 2
Thimo_0019	ENOG4105E2K	Glycosyl transferase (Group 1
Thimo_0028	ENOG4105CF4	DegT DnrJ EryC1 StrS aminotransferase
Thimo_0035	ENOG4105J5G	Transferase hexapeptide repeat containing protein
Thimo_0036	ENOG4107R5Z	Oxidoreductase domain protein
Thimo_0041	ENOG4105DIK	(ABC) transporter
Thimo_0042	ENOG4105NXV	High-affinity zinc uptake system protein
Thimo_0043	ENOG4105D1C	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion (By similarity)
Thimo_0044	ENOG4107QHF	type ii secretion system protein e
Thimo_0045	ENOG4105D7Q	type ii secretion system
Thimo_0046	ENOG4108VAU	general secretion pathway protein G
Thimo_0047	ENOG4105WMT	general secretion pathway protein h
Thimo_0050	ENOG4105UV2	general secretion pathway protein K
Thimo_0051	ENOG41090VX	general secretion pathway protein L
Thimo_0054	ENOG4105GVR	general secretion pathway protein D
Thimo_0055	ENOG4105CNK	Required, probably indirectly, for the hydroxylation of 2-octaprenylphenol to 2-octaprenyl-6-hydroxy-phenol, the fourth step in ubiquinone biosynthesis (By similarity)
Thimo_0056	ENOG4105JC1	sterol-binding domain protein
Thimo_0057	ENOG4105DDZ	Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity)
Thimo_0058	ENOG4105C6P	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity)
Thimo_0060	ENOG4105CE8	Transfers the fatty acyl group on membrane lipoproteins (By similarity)
Thimo_0063	ENOG4105DFU	Cell wall formation (By similarity)
Thimo_0064	ENOG4108UMA	3-octaprenyl-4-hydroxybenzoate carboxy-lyase
Thimo_0068	ENOG4108KF1	Membrane
Thimo_0069	ENOG4105CDM	Glutamate-1-semialdehyde aminotransferase
Thimo_0070	ENOG4108UV6	Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity)
Thimo_0071	ENOG4105DWF	phosphomethylpyrimidine kinase
Thimo_0072	ENOG4105VCQ	rubredoxin
Thimo_0074	ENOG4108YX9	iron--sulfur cluster insertion protein erpA
Thimo_0075	ENOG4105C0N	N-acetylglutamate semialdehyde dehydrogenase
Thimo_0076	ENOG4105C4R	Atp-dependent dna helicase
Thimo_0077	ENOG4105CH5	extracellular solute-binding protein, family 7
Thimo_0078	ENOG4105CSA	Coproporphyrinogen iii oxidase
Thimo_0079	ENOG4105VFB	Binds the 23S rRNA (By similarity)
Thimo_0081	ENOG4105BZN	citrate synthase
Thimo_0087	ENOG4105E4G	Type IV pilus
Thimo_0088	ENOG4105KHV	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity)
Thimo_0089	ENOG4105D49	3-dehydroquinate synthase
Thimo_0092	ENOG4108YXY	alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
Thimo_0093	ENOG4105BZU	Histidine kinase
Thimo_0094	ENOG4105DW3	Response regulator receiver modulated metal dependent phosphohydrolase
Thimo_0096	ENOG4105CCX	Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity)
Thimo_0097	ENOG4105BZU	Histidine kinase
Thimo_0098	ENOG4108YZA	Nitrogen regulatory protein pii
Thimo_0101	ENOG4105C0P	Mg chelatase subunit ChlI
Thimo_0102	ENOG4105C5H	ABC transporter
Thimo_0105	ENOG4105DZP	Membrane-associated zinc metalloprotease
Thimo_0106	ENOG4105HJX	Biotin- acetyl-CoA-carboxylase ligase
Thimo_0107	ENOG4105BZU	Histidine kinase
Thimo_0110	ENOG4105ERG	peptidase m48, ste24p
Thimo_0113	ENOG4108ZF1	Transcriptional regulator, BadM Rrf2 family
Thimo_0116	ENOG4105DSF	transport protein
Thimo_0120	ENOG4105E99	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity)
Thimo_0122	ENOG4107TH8	cina domain protein
Thimo_0123	ENOG4108V06	Glutathione peroxidase
Thimo_0124	ENOG4105DP0	ferredoxin-NADP reductase
Thimo_0126	ENOG4105SA9	Catalyzes the transfer of the L-Ara4N moiety of the glycolipid undecaprenyl phosphate-alpha-L-Ara4N to lipid A. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides (By similarity)
Thimo_0127	ENOG4105CKK	Glycosyl transferase, family 2
Thimo_0128	ENOG4108ZNX	Heat shock protein
Thimo_0129	ENOG4105C0H	protease
Thimo_0131	ENOG4105E3I	toluene tolerance
Thimo_0133	ENOG4105D52	delta-aminolevulinic acid dehydratase
Thimo_0134	ENOG4105E2X	shikimate dehydrogenase
Thimo_0143	ENOG4105CY1	sulfite reductase, dissimilatory-type alpha subunit
Thimo_0144	ENOG4105PJW	Sulfite reductase dissimilatory-type beta subunit
Thimo_0145	ENOG4108ZAT	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE (By similarity)
Thimo_0146	ENOG4108ZKU	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions (By similarity)
Thimo_0148	ENOG4108Z0T	Part of a sulfur-relay system (By similarity)
Thimo_0153	ENOG4105QA4	4Fe-4S Ferredoxin, iron-sulfur binding domain protein
Thimo_0155	ENOG4105C0Y	Responsible for the amidation of carboxylic groups at position A and C of either cobyrinic acid or hydrogenobrynic acid. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity)
Thimo_0158	ENOG4105E1F	short-chain dehydrogenase reductase
Thimo_0160	ENOG4105C5X	domain protein
Thimo_0169	ENOG4105E06	May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity)
Thimo_0171	ENOG4105D4U	had-superfamily hydrolase, subfamily iia
Thimo_0175	ENOG4105CJ9	Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity)
Thimo_0176	ENOG4105K5Y	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity)
Thimo_0178	ENOG4105VF7	tolerance protein
Thimo_0179	ENOG4105CSG	Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps (By similarity)
Thimo_0181	ENOG4108Z38	Catalyzes a trans-dehydration via an enolate intermediate (By similarity)
Thimo_0182	ENOG4105KM4	Acetyl-CoA carboxylase, biotin carboxyl carrier protein
Thimo_0183	ENOG4105CER	acetyl-CoA carboxylase biotin carboxylase
Thimo_0184	ENOG4105F59	Methylates ribosomal protein L11 (By similarity)
Thimo_0185	ENOG4105CEH	Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity)
Thimo_0186	ENOG4105VY0	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters (By similarity)
Thimo_0187	ENOG4105DC1	bifunctional purine biosynthesis protein purh
Thimo_0188	ENOG4105DAF	Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity)
Thimo_0189	ENOG4105C12	Phosphoribosylglycinamide synthetase
Thimo_0190	ENOG4105ERU	peptidase
Thimo_0191	ENOG4108EQH	DNA internalization-related competence protein ComEC Rec2
Thimo_0193	ENOG4105CQU	Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity)
Thimo_0194	ENOG4105D60	lipoprotein releasing system transmembrane protein
Thimo_0195	ENOG4105DWY	Agmatine deiminase
Thimo_0197	ENOG4105CK2	sodium dicarboxylate symporter
Thimo_0199	ENOG41082AG	Plasmid maintenance system antidote protein
Thimo_0208	ENOG4108ZAI	phosphatidylglycerophosphatase a
Thimo_0209	ENOG4105CG2	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity)
Thimo_0210	ENOG4107YIM	Involved in the transcription termination process (By similarity)
Thimo_0212	ENOG4105C66	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity)
Thimo_0219	ENOG4105DHQ	Histidine kinase
Thimo_0223	ENOG4105CJG	carbon-monoxide dehydrogenase catalytic subunit
Thimo_0225	ENOG4105EUS	Binding-protein-dependent transport systems, inner membrane component
Thimo_0226	ENOG4105D7T	ABC transporter
Thimo_0229	ENOG4107SVV	electron transport complex, RnfABCDGE type, B subunit
Thimo_0230	ENOG4105DGN	Electron transport complex
Thimo_0231	ENOG4105DZB	Electron transport complex
Thimo_0232	ENOG41080WF	Electron transport complex, RnfABCDGE type, G subunit
Thimo_0233	ENOG4105D6A	Electron transport complex
Thimo_0234	ENOG4107QTR	Required for nitrogen fixation. May be part of a membrane complex functioning as an intermediate in the electron transport to nitrogenase (By similarity)
Thimo_0235	ENOG4105CH8	Succinyl-CoA ligase ADP-forming subunit alpha
Thimo_0236	ENOG4105CMV	Succinyl-CoA synthetase subunit beta
Thimo_0237	ENOG4108IIE	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity)
Thimo_0238	ENOG4105C15	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity)
Thimo_0239	ENOG4105D9Z	Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity)
Thimo_0241	ENOG4105CMV	Succinyl-CoA synthetase subunit beta
Thimo_0242	ENOG4105CH8	Succinyl-CoA ligase ADP-forming subunit alpha
Thimo_0243	ENOG4105CQI	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity)
Thimo_0244	ENOG4105E9K	Isocitrate dehydrogenase
Thimo_0246	ENOG4108IYU	L-aspartate oxidase
Thimo_0250	ENOG4105DI2	Pyruvate flavodoxin ferredoxin oxidoreductase domain protein
Thimo_0251	ENOG4105DQU	oxidoreductase, subunit beta
Thimo_0253	ENOG4105CVN	desaturase
Thimo_0261	ENOG4105MQ3	flagellar protein FliS
Thimo_0264	ENOG41063QE	flagellar protein FlaG
Thimo_0265	ENOG4105DTS	flagellar hook-associated
Thimo_0268	ENOG4105C1W	two component, sigma54 specific, transcriptional regulator, Fis family
Thimo_0270	ENOG4105C1F	The M ring may be actively involved in energy transduction (By similarity)
Thimo_0271	ENOG4105CS3	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity)
Thimo_0273	ENOG4108JIR	Flagellum-specific ATP synthase
Thimo_0277	ENOG4105D24	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity)
Thimo_0278	ENOG4105DD5	Flagellar motor switch protein
Thimo_0279	ENOG4105K0P	flagellar biosynthesis protein
Thimo_0280	ENOG4105CN7	Flagellar biosynthetic protein FliP
Thimo_0281	ENOG4105VS8	Flagellar biosynthetic protein fliq
Thimo_0282	ENOG4105D19	Role in flagellar biosynthesis (By similarity)
Thimo_0283	ENOG4105D00	flagellar biosynthetic protein flhB
Thimo_0284	ENOG4105D7B	Flagellar biosynthesis protein flha
Thimo_0285	ENOG4105FZW	flagellar biosynthesis regulator FlhF
Thimo_0286	ENOG4107R21	site-determining protein
Thimo_0287	ENOG4105DN4	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity)
Thimo_0293	ENOG4105ER2	Ompa motb domain protein
Thimo_0294	ENOG4105E14	MotA TolQ exbB proton channel
Thimo_0296	ENOG4108UKH	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity)
Thimo_0297	ENOG4105CU6	carbamoyl-phosphate synthetase ammonia chain
Thimo_0298	ENOG4105C1M	carbamoyl-phosphate synthetase glutamine chain
Thimo_0301	ENOG4105D6C	Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity)
Thimo_0304	ENOG4105C5I	Dehydrogenase
Thimo_0325	ENOG41062VX	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease (By similarity)
Thimo_0328	ENOG4108UK5	Transposase
Thimo_0329	ENOG4105C8N	cysteinyl-tRNA synthetase
Thimo_0330	ENOG4108R5K	PPIases accelerate the folding of proteins (By similarity)
Thimo_0334	ENOG4105C9U	ATP-dependent DNA helicase RecQ
Thimo_0339	ENOG4105BZM	domain protein
Thimo_0342	ENOG4105C65	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity)
Thimo_0343	ENOG4108Z11	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity)
Thimo_0344	ENOG4105D1W	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity)
Thimo_0347	ENOG41070EG	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes (By similarity)
Thimo_0352	ENOG4105CM1	Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity)
Thimo_0355	ENOG4105C4M	(Ubiquinol oxidase) subunit I
Thimo_0356	ENOG4105CFY	cytochrome d ubiquinol oxidase, subunit ii
Thimo_0358	ENOG4108JJ9	ABC, transporter
Thimo_0359	ENOG4108JJ8	(ABC) transporter
Thimo_0365	ENOG4107UB2	Alpha beta hydrolase fold
Thimo_0372	ENOG4105D9I	Responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6 (By similarity)
Thimo_0374	ENOG4105BZU	Histidine kinase
Thimo_0376	ENOG4108VK3	Cupin 2 Conserved Barrel Domain Protein
Thimo_0377	ENOG4108JUA	Transcriptional regulator
Thimo_0379	ENOG4105CV9	cyclopropane-fatty-acyl-phospholipid synthase
Thimo_0380	ENOG4105E0X	reductase
Thimo_0382	ENOG4105C7K	acetolactate synthase
Thimo_0383	ENOG4108ZP8	Acetolactate synthase small subunit
Thimo_0384	ENOG4105C6M	Alpha-keto-beta-hydroxylacyl reductoisomerase
Thimo_0385	ENOG4105F7V	ErfK ybiS ycfS ynhG family protein
Thimo_0390	ENOG4107S75	HAD-superfamily hydrolase subfamily IA variant 3
Thimo_0392	ENOG4105CHR	reductase
Thimo_0402	ENOG4105CCY	NADH flavin oxidoreductase, NADH oxidase
Thimo_0404	ENOG4105EXG	Transcriptional regulator
Thimo_0411	ENOG4105D1S	lipid A biosynthesis
Thimo_0413	ENOG4105E1Z	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
Thimo_0417	ENOG4108Z0T	Part of a sulfur-relay system (By similarity)
Thimo_0419	ENOG4105C6R	Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity)
Thimo_0423	ENOG4108ZF1	Transcriptional regulator, BadM Rrf2 family
Thimo_0424	ENOG4105C76	Specifically methylates the 50S ribosomal protein L3 on a specific glutamine residue (By similarity)
Thimo_0426	ENOG4105D4P	Coproporphyrinogen iii oxidase
Thimo_0427	ENOG4105CEY	Amp-dependent synthetase and ligase
Thimo_0429	ENOG4105DEA	Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation
Thimo_0430	ENOG4105CCQ	Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity)
Thimo_0431	ENOG4105CHN	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity)
Thimo_0432	ENOG4105C6P	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity)
Thimo_0433	ENOG4105K70	DNA-binding protein
Thimo_0436	ENOG4105DBD	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation (By similarity)
Thimo_0437	ENOG4105CSJ	Enoyl- acyl-carrier-protein reductase NADH
Thimo_0438	ENOG4105C1G	acyl-Coa dehydrogenase
Thimo_0439	ENOG4105C10	Electron transfer flavoprotein
Thimo_0440	ENOG4105BZJ	Electron transfer flavoprotein
Thimo_0442	ENOG4105EXZ	Involved in the regulation of ptsG expression by binding and inactivating Mlc (By similarity)
Thimo_0447	ENOG4108ZJD	Protein of unknown function (DUF1109)
Thimo_0448	ENOG4105NCT	RNA Polymerase
Thimo_0450	ENOG4107U7B	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity)
Thimo_0452	ENOG4105C24	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
Thimo_0455	ENOG4105C2R	Single-stranded-DNA-specific exonuclease (RecJ)
Thimo_0459	ENOG4105EKQ	RNA-directed DNA polymerase
Thimo_0460	ENOG4105NQN	cytochrome C
Thimo_0463	ENOG4105N42	UPF0307 protein
Thimo_0465	ENOG4105N1I	succinate dehydrogenase, hydrophobic membrane anchor protein
Thimo_0466	ENOG4105C00	Succinate dehydrogenase (Flavoprotein subunit)
Thimo_0467	ENOG4105E33	succinate dehydrogenase
Thimo_0468	ENOG4105Y75	tpr repeat protein
Thimo_0469	ENOG4107TXC	Transcriptional regulator
Thimo_0471	ENOG41079YP	Citrate utilization protein b
Thimo_0472	ENOG4107EFR	Flavocytochrome c
Thimo_0473	ENOG4105CAA	catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity)
Thimo_0481	ENOG4105CV8	reductase
Thimo_0484	ENOG4105CAA	catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity)
Thimo_0495	ENOG4105C3R	Methionine synthase
Thimo_0500	ENOG4105C0Y	Responsible for the amidation of carboxylic groups at position A and C of either cobyrinic acid or hydrogenobrynic acid. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity)
Thimo_0501	ENOG4105DH2	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group (By similarity)
Thimo_0502	ENOG4108YZT	Adenosylcobinamide kinase
Thimo_0513	ENOG4105CB9	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
Thimo_0515	ENOG4108NJZ	Sensory box GGDEF EAL domain protein
Thimo_0517	ENOG4105DW0	Catalyzes the ADP transfer to D-glycero-D-manno-heptose 1-phosphate, yielding ADP-D,D-heptose (By similarity)
Thimo_0518	ENOG4105F55	Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate (By similarity)
Thimo_0527	ENOG4107ZBH	radical SAM domain protein
Thimo_0531	ENOG4107QQB	Ribonuclease E
Thimo_0532	ENOG4105EI2	Pseudouridine synthase
Thimo_0533	ENOG4108VXP	Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity)
Thimo_0535	ENOG4105E9H	Lytic Murein transglycosylase
Thimo_0536	ENOG4108UHJ	MAF-like protein
Thimo_0540	ENOG4105BZU	Histidine kinase
Thimo_0544	ENOG4108V7X	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
Thimo_0545	ENOG4108Z0T	Part of a sulfur-relay system (By similarity)
Thimo_0552	ENOG4105DG1	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity)
Thimo_0553	ENOG4105C9G	DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity)
Thimo_0555	ENOG4105VCC	30S ribosomal protein S21
Thimo_0557	ENOG4105CPM	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity)
Thimo_0558	ENOG4105K7Z	Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity)
Thimo_0566	ENOG4105HF0	Membrane
Thimo_0569	ENOG4107SA8	fad-dependent pyridine nucleotide-disulfide oxidoreductase
Thimo_0570	ENOG4107YD3	Thioesterase
Thimo_0571	ENOG4105E02	MotA TolQ exbB proton channel
Thimo_0572	ENOG4105M8F	Biopolymer transport protein exbD tolR
Thimo_0574	ENOG4107R6Y	Involved in the TonB-independent uptake of proteins (By similarity)
Thimo_0575	ENOG4105KCK	Peptidoglycan-associated lipoprotein
Thimo_0577	ENOG4107VRB	Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity)
Thimo_0581	ENOG4108UH4	Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity)
Thimo_0582	ENOG4105CP7	Triose-phosphate isomerase
Thimo_0583	ENOG4107EJC	Preprotein translocase subunit SecG
Thimo_0585	ENOG4105KWU	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
Thimo_0586	ENOG4105ES3	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
Thimo_0587	ENOG4105CYU	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
Thimo_0588	ENOG4105CQV	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
Thimo_0590	ENOG4107QIZ	NADH dehydrogenase
Thimo_0592	ENOG4105CMZ	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone (By similarity)
Thimo_0593	ENOG41081XG	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
Thimo_0594	ENOG4105DF2	NADH dehydrogenase subunit j
Thimo_0595	ENOG4105M5H	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
Thimo_0597	ENOG4105C8S	subunit m
Thimo_0598	ENOG4105CNR	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
Thimo_0602	ENOG4105D6Z	AFG1 family ATPase
Thimo_0610	ENOG4108QVN	serine threonine protein kinase
Thimo_0612	ENOG4105DVS	Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity)
Thimo_0613	ENOG4105F4R	Transcriptional regulator mode
Thimo_0614	ENOG4108S6J	ABC transporter, periplasmic molybdate-binding protein
Thimo_0615	ENOG4105E0C	molybdate abc transporter
Thimo_0616	ENOG4105CGB	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system (By similarity)
Thimo_0617	ENOG4107XWS	modD protein
Thimo_0618	ENOG4105CN0	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity)
Thimo_0624	ENOG4105BZU	Histidine kinase
Thimo_0625	ENOG4105BZU	Histidine kinase
Thimo_0631	ENOG4105CG6	trap dicarboxylate transporter dctm subunit
Thimo_0635	ENOG4107RBB	ABC transporter, permease
Thimo_0636	ENOG4105D6C	Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity)
Thimo_0648	ENOG4105CZX	twitching motility protein
Thimo_0649	ENOG4107QHF	type ii secretion system protein e
Thimo_0650	ENOG4105D7Q	type ii secretion system
Thimo_0652	ENOG4105GVR	general secretion pathway protein D
Thimo_0654	ENOG4105E4C	Lytic transglycosylase catalytic
Thimo_0655	ENOG4108UQQ	Electron transport complex
Thimo_0657	ENOG4107SJW	iron permease, FTR1
Thimo_0658	ENOG4105F8C	transglutaminase domain-containing protein
Thimo_0660	ENOG4105C7R	Atpase associated with various cellular activities aaa_3
Thimo_0665	ENOG4105BZU	Histidine kinase
Thimo_0666	ENOG4105CJE	phosphoribulokinase (EC 2.7.1.19)
Thimo_0667	ENOG4108JU5	Magnesium and cobalt efflux protein
Thimo_0668	ENOG4105KGE	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity)
Thimo_0669	ENOG4105C9A	Phoh family
Thimo_0670	ENOG4105CIW	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity)
Thimo_0673	ENOG41089BK	Glutamine amido-transferase
Thimo_0674	ENOG4105C7D	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
Thimo_0675	ENOG4105D7A	ATP-binding protein
Thimo_0677	ENOG4108I5C	dEAD DEAH box helicase
Thimo_0680	ENOG4105C7P	2-oxoglutarate dehydrogenase, E1
Thimo_0681	ENOG4105C7S	Dehydrogenase
Thimo_0685	ENOG4105C9X	ppx gppa phosphatase
Thimo_0689	ENOG4105CZX	twitching motility protein
Thimo_0690	ENOG4105CZX	twitching motility protein
Thimo_0691	ENOG4108UM6	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity)
Thimo_0700	ENOG4105GPY	SprT protein
Thimo_0701	ENOG4105K7D	Required for maturation of 30S ribosomal subunits (By similarity)
Thimo_0702	ENOG4105CHV	Transcription elongation factor NusA
Thimo_0703	ENOG4107QHU	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity)
Thimo_0704	ENOG4105KG7	Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity)
Thimo_0705	ENOG4105D0T	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity)
Thimo_0706	ENOG4105K77	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity)
Thimo_0707	ENOG4105C62	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity)
Thimo_0708	ENOG4105EGS	Mechanosensitive ion channel
Thimo_0709	ENOG4105J0Q	Transcriptional regulator
Thimo_0710	ENOG4105CYQ	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity)
Thimo_0711	ENOG4105W0E	50S ribosomal protein L33
Thimo_0712	ENOG4105KDC	50s ribosomal protein l28
Thimo_0713	ENOG4105C4H	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity)
Thimo_0714	ENOG4108V9Q	carbonic anhydrase
Thimo_0717	ENOG4105E1P	Modifies, by uridylylation or deuridylylation the PII (GlnB) regulatory protein (By similarity)
Thimo_0718	ENOG4105CA1	Removes the N-terminal methionine from nascent proteins (By similarity)
Thimo_0719	ENOG4105CE9	30S ribosomal protein S2
Thimo_0720	ENOG4105CU7	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity)
Thimo_0721	ENOG4105C41	Catalyzes the reversible phosphorylation of UMP to UDP (By similarity)
Thimo_0722	ENOG4108VCV	Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity)
Thimo_0723	ENOG4105CR3	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity)
Thimo_0724	ENOG4105KNE	Phosphatidate cytidylyltransferase
Thimo_0725	ENOG4105CEA	Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity)
Thimo_0726	ENOG4105DZP	Membrane-associated zinc metalloprotease
Thimo_0727	ENOG4105E1Z	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
Thimo_0729	ENOG4105D7M	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity)
Thimo_0730	ENOG4108YXN	Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity)
Thimo_0731	ENOG4105DAF	Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity)
Thimo_0734	ENOG4105C4E	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity)
Thimo_0737	ENOG4105DXN	mazG family
Thimo_0738	ENOG4105W5Q	DNA repair protein (RadC
Thimo_0740	ENOG4108Z1K	This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity)
Thimo_0742	ENOG4105CAS	nag kinase
Thimo_0744	ENOG4107QP2	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity)
Thimo_0747	ENOG4105VZ9	UPF0235 protein
Thimo_0748	ENOG4108VIA	integral membrane protein
Thimo_0749	ENOG4105II7	pyrroline-5-carboxylate reductase
Thimo_0750	ENOG4105DFA	alanine racemase domain protein
Thimo_0751	ENOG4108V82	Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity)
Thimo_0752	ENOG4105ED0	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity)
Thimo_0753	ENOG4107WDG	serine threonine protein kinase
Thimo_0754	ENOG4105DSJ	YicC domain protein
Thimo_0755	ENOG4108UHA	Essential for recycling GMP and indirectly, cGMP (By similarity)
Thimo_0756	ENOG4105VFG	Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity)
Thimo_0757	ENOG4105CWR	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity)
Thimo_0759	ENOG4105KME	endoribonuclease L-psp
Thimo_0760	ENOG4105C8V	SAICAR synthetase
Thimo_0761	ENOG4105BZU	Histidine kinase
Thimo_0762	ENOG4108RW0	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity)
Thimo_0763	ENOG4105C2V	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity)
Thimo_0764	ENOG4105DUM	transcriptional regulator, lysR family
Thimo_0765	ENOG4105DT1	RuBisCO catalyzes two reactions the carboxylation of D- ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate
Thimo_0766	ENOG4108VFZ	ribulose bisphosphate carboxylase, small
Thimo_0767	ENOG4105BZU	Histidine kinase
Thimo_0774	ENOG4105E3S	small subunit
Thimo_0777	ENOG4105DPX	Hydrogenase, large subunit
Thimo_0784	ENOG4105DHM	ATPase which is responsible for recognizing, binding, unfolding and translocation of pupylated proteins into the bacterial 20S proteasome core particle. May be essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C-termini of the proteasomal ATPase may function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis (By similarity)
Thimo_0822	ENOG4107TUY	Histidine kinase
Thimo_0823	ENOG4105C1W	two component, sigma54 specific, transcriptional regulator, Fis family
Thimo_0828	ENOG41067MG	lrgb family
Thimo_0834	ENOG4105BZU	Histidine kinase
Thimo_0840	ENOG4105VYW	UPF0251 protein
Thimo_0844	ENOG4105CC8	Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity)
Thimo_0845	ENOG41080RH	Thioredoxin
Thimo_0848	ENOG4108MHR	Repressor involved in choline regulation of the bet genes (By similarity)
Thimo_0849	ENOG4105C1P	efflux transporter, rnd family, mfp subunit
Thimo_0850	ENOG4105BZS	acriflavin resistance protein
Thimo_0851	ENOG4105FQ6	thiopurine methyltransferase
Thimo_0853	ENOG4105BZU	Histidine kinase
Thimo_0854	ENOG4105BZU	Histidine kinase
Thimo_0856	ENOG4108VDT	Glycosyl transferase family protein
Thimo_0873	ENOG4105BZU	Histidine kinase
Thimo_0876	ENOG4105CD9	Involved in the production of pyridoxal phosphate, probably by incorporating ammonia into the pyridine ring (By similarity)
Thimo_0877	ENOG4108UHX	Involved in the hydrolysis of glutamine to glutamate and ammonia. Channels an ammonia molecule to PdxS (By similarity)
Thimo_0883	ENOG4105CEY	Amp-dependent synthetase and ligase
Thimo_0884	ENOG4105DT1	RuBisCO catalyzes two reactions the carboxylation of D- ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate
Thimo_0887	ENOG4108ZEY	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP) (By similarity)
Thimo_0901	ENOG4108JUA	Transcriptional regulator
Thimo_0915	ENOG4105CDB	Required for chromosome condensation and partitioning (By similarity)
Thimo_0916	ENOG4107NPY	receptor for the septal ring structure, may anchor it to the inner-membrane (By similarity)
Thimo_0917	ENOG4105C77	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity)
Thimo_0921	ENOG4105DB3	bacteriochlorophyll chlorophyll a synthase
Thimo_0922	ENOG4107QZT	geranylgeranyl reductase
Thimo_0923	ENOG4105C6T	cysteine synthase
Thimo_0927	ENOG4107R11	Transcriptional regulator
Thimo_0930	ENOG4108A51	
Thimo_0931	ENOG4107XQ1	cobalamin (vitamin B12) biosynthesis CbiM protein
Thimo_0934	ENOG4107QM9	Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (By similarity)
Thimo_0935	ENOG4105D3U	Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity)
Thimo_0937	ENOG4105CV9	cyclopropane-fatty-acyl-phospholipid synthase
Thimo_0942	ENOG4105D38	putrescine abc transporter
Thimo_0943	ENOG4105F38	ABC transporter, permease
Thimo_0944	ENOG4105C53	Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity)
Thimo_0946	ENOG4105D9N	nucleoside
Thimo_0947	ENOG4105F4C	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress (By similarity)
Thimo_0951	ENOG4105QA4	4Fe-4S Ferredoxin, iron-sulfur binding domain protein
Thimo_0953	ENOG4105BZU	Histidine kinase
Thimo_0954	ENOG4108ZGN	Component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. The KaiABC complex may act as a promoter-non-specific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction. In the complex, it decreases the phosphorylation status of KaiC. It has no effect on KaiC by itself, but instead needs the presence of both KaiA and KaiC, suggesting that it acts by antagonizing the interaction between KaiA and KaiC (By similarity)
Thimo_0956	ENOG4105E39	Enoyl-CoA hydratase
Thimo_0959	ENOG4105CKH	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity)
Thimo_0960	ENOG4105DGN	Electron transport complex
Thimo_0961	ENOG4108R3D	Electron transport complex
Thimo_0965	ENOG4105DZB	Electron transport complex
Thimo_0967	ENOG4107TF3	peptidylprolyl cis-trans isomerase
Thimo_0968	ENOG4105K9H	YciI-like protein
Thimo_0969	ENOG4107835	probably involved in intracellular septation (By similarity)
Thimo_0970	ENOG4105DB7	PHP domain protein
Thimo_0971	ENOG4107RTD	sua5 ycio yrdc ywlc family protein
Thimo_0972	ENOG4108Z4T	Peptidase M50
Thimo_0973	ENOG4105C31	Tryptophanyl-tRNA synthetase
Thimo_0974	ENOG4108KVX	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves (By similarity)
Thimo_0975	ENOG4105K8I	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity)
Thimo_0992	ENOG4105CAQ	asparagine synthetase
Thimo_1004	ENOG4107R5M	Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity)
Thimo_1005	ENOG4107RDJ	Sulfotransferase
Thimo_1006	ENOG4106WTF	Glycosyl transferase, family 2
Thimo_1007	ENOG4108HWB	Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity)
Thimo_1013	ENOG4107TYG	Oxidoreductase domain-containing protein
Thimo_1019	ENOG4105EAG	UDP-N-acetylglucosamine 2-epimerase
Thimo_1028	ENOG4105J1P	transposase, IS3 IS911 family protein
Thimo_1032	ENOG4108YX9	iron--sulfur cluster insertion protein erpA
Thimo_1034	ENOG4105DA0	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity)
Thimo_1040	ENOG4108RB3	Capsular polysaccharide biosynthesis protein
Thimo_1043	ENOG4105CVE	Lytic murein transglycosylase
Thimo_1044	ENOG4105CB5	ATP-dependent DNA helicase recG
Thimo_1045	ENOG4105C4G	Synthesis of 3-octaprenyl-4-hydroxybenzoate (By similarity)
Thimo_1047	ENOG4108ZQD	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity)
Thimo_1048	ENOG4105EHH	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue (By similarity)
Thimo_1050	ENOG4107QHF	type ii secretion system protein e
Thimo_1052	ENOG4108IQF	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity)
Thimo_1053	ENOG4105C7Z	Conserved Protein
Thimo_1054	ENOG4107QP3	malate synthase g
Thimo_1057	ENOG4105E2N	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity)
Thimo_1058	ENOG4107QXP	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity)
Thimo_1060	ENOG4105C6U	Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity)
Thimo_1061	ENOG4105VIE	preprotein translocase, subunit YajC
Thimo_1062	ENOG4107QN8	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity)
Thimo_1063	ENOG4107RAB	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity)
Thimo_1064	ENOG4105ECY	inositol monophosphatase
Thimo_1068	ENOG4105QF0	Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity)
Thimo_1069	ENOG4105M08	Membrane
Thimo_1071	ENOG4105CH7	arginosuccinase
Thimo_1075	ENOG4107RVU	D-Ala-D-Ala carboxypeptidase 3 (S13) family
Thimo_1076	ENOG4105C0H	protease
Thimo_1077	ENOG4108YZY	peptidylprolyl cis-trans isomerase
Thimo_1080	ENOG4108Z1W	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity)
Thimo_1081	ENOG4105C2S	Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity)
Thimo_1083	ENOG4108U2H	Rare lipoprotein B
Thimo_1084	ENOG4105C8T	Leucyl-tRNA synthetase
Thimo_1085	ENOG4107QN2	dihydrolipoyl dehydrogenase
Thimo_1086	ENOG4107QSN	dihydrolipoamide acetyltransferase
Thimo_1087	ENOG4105DAQ	Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity)
Thimo_1096	ENOG4105CHM	Aminotransferase
Thimo_1097	ENOG4105D6E	homoserine dehydrogenase
Thimo_1099	ENOG4105DNZ	Alpha Beta Hydrolase
Thimo_1100	ENOG4105DFG	type I secretion outer membrane protein
Thimo_1101	ENOG4105D10	5-enolpyruvylshikimate-3-phosphate phospholyase
Thimo_1107	ENOG4105CY3	ABC transporter, permease
Thimo_1108	ENOG4105K6T	rare lipoprotein A
Thimo_1111	ENOG4105U6C	Alpha beta hydrolase fold protein
Thimo_1114	ENOG4107QVM	von Willebrand factor, type A
Thimo_1118	ENOG4105C7R	Atpase associated with various cellular activities aaa_3
Thimo_1125	ENOG4105VQD	rieske 2fe-2S domain-containing protein
Thimo_1126	ENOG4106RZ4	Peptidase U32
Thimo_1127	ENOG4105CFP	Peptidase U32
Thimo_1128	ENOG4105N5T	Radical SAM Protein
Thimo_1131	ENOG4106N16	had-superfamily hydrolase, subfamily iib
Thimo_1137	ENOG4105D9I	Responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6 (By similarity)
Thimo_1139	ENOG4105C07	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity)
Thimo_1140	ENOG4105DTN	riboflavin biosynthesis protein ribF
Thimo_1141	ENOG4105CJR	Integral membrane protein (MviN
Thimo_1142	ENOG4107TYR	Glycosyl Transferase
Thimo_1143	ENOG4105BZU	Histidine kinase
Thimo_1151	ENOG4108UJV	acyl-CoA thioesterase i
Thimo_1153	ENOG4105C8U	phosphate abc transporter
Thimo_1154	ENOG4105E2Z	phosphate ABC transporter (Permease
Thimo_1155	ENOG4105BZY	Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity)
Thimo_1156	ENOG4107QMV	Part of the ABC transporter complex PstSACB involved in phosphate import (By similarity)
Thimo_1158	ENOG4105D7N	magnesium and cobalt transport protein CorA
Thimo_1159	ENOG4105C7R	Atpase associated with various cellular activities aaa_3
Thimo_1160	ENOG4107RE5	NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity)
Thimo_1161	ENOG4105D28	Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity)
Thimo_1162	ENOG4107QJE	Chromosome Partitioning Protein
Thimo_1163	ENOG4105FA0	parb-like partition protein
Thimo_1165	ENOG4107RAZ	it plays a direct role in the translocation of protons across the membrane (By similarity)
Thimo_1166	ENOG4105KY6	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity)
Thimo_1167	ENOG4107Z6K	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity)
Thimo_1168	ENOG4107S15	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity)
Thimo_1169	ENOG4105CDG	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity)
Thimo_1171	ENOG4105C4J	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity)
Thimo_1172	ENOG4105KNM	Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity)
Thimo_1173	ENOG4105CAJ	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity)
Thimo_1174	ENOG4105C46	Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity)
Thimo_1175	ENOG4105DDQ	anthranilate synthase
Thimo_1176	ENOG4108I0Q	anthranilate phosphoribosyltransferase
Thimo_1177	ENOG4105DK0	Indole-3-glycerol phosphate synthase
Thimo_1178	ENOG4107RYR	Transcriptional regulator, Crp Fnr family
Thimo_1180	ENOG4105FDS	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity)
Thimo_1181	ENOG4108S0N	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol (By similarity)
Thimo_1182	ENOG4105CHG	glycolate oxidase (iron-sulfur subunit)
Thimo_1183	ENOG4108UM5	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity)
Thimo_1187	ENOG4105E66	phosphoriboisomerase A
Thimo_1188	ENOG4105C7B	Threonine dehydratase
Thimo_1190	ENOG4105MK2	5-formyltetrahydrofolate cyclo-ligase
Thimo_1192	ENOG4105W8B	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division (By similarity)
Thimo_1194	ENOG4105E07	UPF0149 protein
Thimo_1195	ENOG4107RAQ	aminopeptidase
Thimo_1196	ENOG4105D0A	hydroxylase
Thimo_1197	ENOG4105EAK	ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family
Thimo_1198	ENOG4107R15	K00850 6-phosphofructokinase 1 EC 2.7.1.11
Thimo_1199	ENOG4105EAY	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
Thimo_1200	ENOG4105F0N	pyrophosphate phospho-hydrolase
Thimo_1201	ENOG4108YXW	Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity)
Thimo_1203	ENOG4105WHM	Necessary for normal cell division and for the maintenance of normal septation (By similarity)
Thimo_1205	ENOG4107UCJ	Catalyzes the synthesis of activated sulfate (By similarity)
Thimo_1206	ENOG4105DMJ	Catalyzes the transfer of an acetyl group from acetyl- CoA to tetrahydrodipicolinate (By similarity)
Thimo_1207	ENOG4105CHM	Aminotransferase
Thimo_1211	ENOG4105E99	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity)
Thimo_1213	ENOG4105BZH	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity)
Thimo_1216	ENOG41083IP	HIT family
Thimo_1217	ENOG4108YZY	peptidylprolyl cis-trans isomerase
Thimo_1223	ENOG4105DF3	Catalyzes the retro-aldol cleavage of 4-hydroxy-2- oxopentanoate to pyruvate and acetaldehyde. Is involved in the meta-cleavage pathway for the degradation of aromatic compounds (By similarity)
Thimo_1226	ENOG4105C26	Dehydrogenase
Thimo_1227	ENOG4105CB3	Required for the thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32) (By similarity)
Thimo_1228	ENOG4105BZS	acriflavin resistance protein
Thimo_1231	ENOG4105BZU	Histidine kinase
Thimo_1235	ENOG4105C9Q	fumarate hydratase class II
Thimo_1240	ENOG4105D37	Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA (By similarity)
Thimo_1241	ENOG4105C1A	potassium transporter peripheral membrane
Thimo_1242	ENOG4105C1W	two component, sigma54 specific, transcriptional regulator, Fis family
Thimo_1243	ENOG4105ES5	Histidine kinase
Thimo_1245	ENOG4105CYJ	ribosomal RNA small subunit methyltransferase B
Thimo_1246	ENOG4105CAE	Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity)
Thimo_1247	ENOG4108Z02	Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity)
Thimo_1249	ENOG4105C79	DNA protecting protein DprA
Thimo_1250	ENOG4108RPN	Protein smg homolog
Thimo_1252	ENOG4107RBD	ABC, transporter
Thimo_1253	ENOG4105CC5	ABC transporter
Thimo_1254	ENOG4105DIK	(ABC) transporter
Thimo_1255	ENOG4105DSE	periplasmic solute binding protein
Thimo_1257	ENOG4105EK0	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity)
Thimo_1260	ENOG4105DIN	metallophosphoesterase
Thimo_1261	ENOG4105E21	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity)
Thimo_1263	ENOG4105E4C	Lytic transglycosylase catalytic
Thimo_1264	ENOG4105CCA	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle (By similarity)
Thimo_1265	ENOG4105D37	Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA (By similarity)
Thimo_1266	ENOG4105VDB	UPF0125 protein
Thimo_1267	ENOG4108E8M	Required for nitrogen fixation. May be part of a membrane complex functioning as an intermediate in the electron transport to nitrogenase (By similarity)
Thimo_1268	ENOG4108UQQ	Electron transport complex
Thimo_1269	ENOG4105D6A	Electron transport complex
Thimo_1270	ENOG4107QTR	Required for nitrogen fixation. May be part of a membrane complex functioning as an intermediate in the electron transport to nitrogenase (By similarity)
Thimo_1271	ENOG4108R3D	Electron transport complex
Thimo_1272	ENOG4105DGN	Electron transport complex
Thimo_1273	ENOG4105DS4	PAS PAC sensor Signal transduction histidine kinase
Thimo_1274	ENOG4108JUA	Transcriptional regulator
Thimo_1275	ENOG4105WBS	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease (By similarity)
Thimo_1276	ENOG4105DYN	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. May be involved in the integration of spacer DNA into the CRISPR cassette (By similarity)
Thimo_1290	ENOG4105C35	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity)
Thimo_1291	ENOG4105D6T	Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity)
Thimo_1294	ENOG4107QN1	sodium solute
Thimo_1296	ENOG4105D98	threonine synthase
Thimo_1297	ENOG4105CYQ	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity)
Thimo_1299	ENOG4105C24	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
Thimo_1300	ENOG4107QM1	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity)
Thimo_1303	ENOG4105CIH	Imidazole acetol-phosphate transaminase
Thimo_1309	ENOG4107QWE	)-transporter
Thimo_1313	ENOG4105EAH	synthase
Thimo_1314	ENOG4105KK9	This protein binds to 23S rRNA in the presence of protein L20 (By similarity)
Thimo_1316	ENOG4105C9R	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
Thimo_1317	ENOG4105CGT	Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity)
Thimo_1318	ENOG4108JDX	DNA polymerase iii, epsilon subunit
Thimo_1321	ENOG4105C8D	Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity)
Thimo_1322	ENOG4105CXR	Phospho-2-dehydro-3-deoxyoctonate aldolase
Thimo_1323	ENOG4105C70	Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity)
Thimo_1324	ENOG4105XX3	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic (By similarity)
Thimo_1325	ENOG4105CE5	Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity)
Thimo_1326	ENOG4108UH8	Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity)
Thimo_1327	ENOG4106NZV	Responsible for synthesis of pseudouridine from uracil- 13 in transfer RNAs (By similarity)
Thimo_1329	ENOG4105CV2	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates (By similarity)
Thimo_1330	ENOG4105E26	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity)
Thimo_1331	ENOG4108UM1	dedA family
Thimo_1332	ENOG4108K5P	(LipO)protein
Thimo_1333	ENOG4105DG1	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity)
Thimo_1338	ENOG4105EUH	cytochrome C oxidase, cbb3-type, subunit i
Thimo_1341	ENOG4105D6P	C-type cytochrome. Part of the cbb3-type cytochrome c oxidase complex (By similarity)
Thimo_1342	ENOG4105C58	cytochrome c oxidase accessory protein ccog
Thimo_1344	ENOG4105C59	p-type ATPase
Thimo_1346	ENOG4105C0G	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity)
Thimo_1347	ENOG4108194	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis (By similarity)
Thimo_1349	ENOG4108V1U	phospholipid-binding protein
Thimo_1350	ENOG4106FI7	cytochrome c-type biogenesis protein
Thimo_1351	ENOG4108M1T	Cytochrome c-type biogenesis protein
Thimo_1352	ENOG4107QX9	Thiol disulfide interChange protein
Thimo_1353	ENOG4105DA4	cytochrome c-type biogenesis protein
Thimo_1354	ENOG4108ZKK	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH (By similarity)
Thimo_1356	ENOG41060IM	Heme exporter protein
Thimo_1357	ENOG4105CA5	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes (By similarity)
Thimo_1358	ENOG4107EV4	once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system (By similarity)
Thimo_1359	ENOG4105D6W	Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity)
Thimo_1360	ENOG41076E6	Uroporphyrinogen-III Synthase
Thimo_1365	ENOG4105D3H	Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity)
Thimo_1366	ENOG4105DGW	oligopeptidase A
Thimo_1368	ENOG4108Z0R	Transferase
Thimo_1369	ENOG4105DY2	Paraquat-inducible protein b
Thimo_1371	ENOG4105F1S	paraquat-inducible protein a
Thimo_1372	ENOG4105E0X	reductase
Thimo_1374	ENOG41090A4	Pterin carbinolamine dehydratase
Thimo_1378	ENOG4105NDF	NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity)
Thimo_1383	ENOG4105CS1	NAD(P)H quinone oxidoreductase
Thimo_1388	ENOG4105DCG	PHP domain protein
Thimo_1389	ENOG4105DKJ	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity)
Thimo_1394	ENOG4107PU6	Membrane
Thimo_1399	ENOG4105C1W	two component, sigma54 specific, transcriptional regulator, Fis family
Thimo_1403	ENOG4107RY0	Catalyzes the conversion of dihydroorotate to orotate (By similarity)
Thimo_1405	ENOG4105CVK	Glutamate decarboxylase
Thimo_1407	ENOG4105EZM	VWA-like domain (DUF2201)
Thimo_1413	ENOG4105ERG	peptidase m48, ste24p
Thimo_1414	ENOG4107XU6	Glycosyl transferase (Group 1
Thimo_1415	ENOG4105CG5	Glycosyl transferase (Group 1
Thimo_1416	ENOG4105CG5	Glycosyl transferase (Group 1
Thimo_1419	ENOG4107EF8	Glycosyl transferase (Group 1
Thimo_1430	ENOG4105D6C	Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity)
Thimo_1431	ENOG4105D6C	Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity)
Thimo_1432	ENOG4105C19	ABC transporter
Thimo_1438	ENOG41082KT	Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity)
Thimo_1442	ENOG41074FZ	May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity)
Thimo_1444	ENOG4105CHI	Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB (By similarity)
Thimo_1454	ENOG4105DZ2	Transcriptional regulator
Thimo_1455	ENOG4105DSS	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity)
Thimo_1456	ENOG4105K8U	2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
Thimo_1462	ENOG4105EJF	Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity)
Thimo_1463	ENOG4108HRM	phosphoenolpyruvate--protein phosphotransferase
Thimo_1464	ENOG4105CQB	FAD linked oxidase domain protein
Thimo_1466	ENOG41082RQ	UPF0102 protein
Thimo_1468	ENOG4107QTF	adenylosuccinate lyase
Thimo_1469	ENOG4107QM5	aconitate hydratase
Thimo_1470	ENOG4105BZG	amino acid carrier protein
Thimo_1471	ENOG4105M85	Bola protein
Thimo_1478	ENOG4105K85	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity)
Thimo_1479	ENOG4105C13	Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity)
Thimo_1480	ENOG4108VPT	UPF0234 protein
Thimo_1481	ENOG4105T95	Thiol disulfide interChange protein
Thimo_1482	ENOG4108ZF3	Phosphatase
Thimo_1485	ENOG4105M56	Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity)
Thimo_1486	ENOG4108JIP	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit (By similarity)
Thimo_1487	ENOG4108JIQ	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit (By similarity)
Thimo_1488	ENOG4105K4G	Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity)
Thimo_1490	ENOG410839E	ATP synthase, F0 subunit c
Thimo_1491	ENOG4107WUB	V-type ATPase 116 kDa subunit
Thimo_1500	ENOG41086N6	Is required to sustain N(2)-dependent growth in the presence of low levels of carbon monoxide (CO). Probably acts by protecting the N(2) fixation ability of the nitrogenase complex, which is inactivated in the presence of CO (By similarity)
Thimo_1506	ENOG4105HBR	Rna-binding protein
Thimo_1509	ENOG4108ZDX	Binds together with S18 to 16S ribosomal RNA (By similarity)
Thimo_1510	ENOG4105VH8	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity)
Thimo_1512	ENOG4105K9Q	Binds to the 23S rRNA (By similarity)
Thimo_1513	ENOG4105CDU	Replicative dna helicase
Thimo_1514	ENOG4105CJ4	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity)
Thimo_1515	ENOG4105DNJ	May play a role in the repair of endogenous alkylation damage (By similarity)
Thimo_1516	ENOG4108MJN	Glycosyl Transferase
Thimo_1519	ENOG4108RSN	SNARE associated Golgi
Thimo_1521	ENOG4105VDW	Csbd family
Thimo_1523	ENOG4105DSF	transport protein
Thimo_1524	ENOG4105CK4	Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity)
Thimo_1525	ENOG4108Z7T	Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity)
Thimo_1532	ENOG4105F59	Methylates ribosomal protein L11 (By similarity)
Thimo_1536	ENOG4105CDA	abc transporter atp-binding protein
Thimo_1537	ENOG4105IDI	abc transporter atp-binding protein
Thimo_1538	ENOG4105D9P	serine threonine protein kinase
Thimo_1542	ENOG4105DRP	amino acid AbC transporter
Thimo_1543	ENOG4105EZ7	amino acid ABC transporter
Thimo_1547	ENOG4107QQX	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity)
Thimo_1550	ENOG4105D37	Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA (By similarity)
Thimo_1559	ENOG4107U9T	Pfam:Ribonuclease_BN
Thimo_1560	ENOG4105SUV	lipoprotein YgdR
Thimo_1561	ENOG4105CWR	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity)
Thimo_1565	ENOG4108I0Y	(ABC) transporter
Thimo_1566	ENOG4108UJV	acyl-CoA thioesterase i
Thimo_1568	ENOG4105DY2	Paraquat-inducible protein b
Thimo_1570	ENOG4105BZU	Histidine kinase
Thimo_1571	ENOG4105CMP	catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity)
Thimo_1573	ENOG4105DJZ	UPF0182 protein
Thimo_1576	ENOG4105J1P	transposase, IS3 IS911 family protein
Thimo_1578	ENOG4105CVG	Homoserine O-transsuccinylase
Thimo_1580	ENOG4105DB1	molybdopterin oxidoreductase
Thimo_1581	ENOG4105QA4	4Fe-4S Ferredoxin, iron-sulfur binding domain protein
Thimo_1582	ENOG4108KDI	dmso reductase anchor subunit
Thimo_1584	ENOG4105DS1	cytochrome b561
Thimo_1588	ENOG4107QMW	pyridine nucleotide-disulfide oxidoreductase
Thimo_1589	ENOG4105BZ8	glutamate synthase
Thimo_1590	ENOG4108TEB	UPF0114 protein
Thimo_1592	ENOG4107QRT	dEAD DEAH box helicase
Thimo_1597	ENOG4105CSR	polyphosphate kinase 2
Thimo_1598	ENOG4105NAU	thioesterase Superfamily protein
Thimo_1604	ENOG4108JQC	penicillin-binding protein 1A
Thimo_1605	ENOG4105CQ7	ATP-dependent helicase
Thimo_1607	ENOG4105BZU	Histidine kinase
Thimo_1609	ENOG4105C3G	gtp-binding protein
Thimo_1613	ENOG4105HPZ	Involved in the removal of murein from the sacculus. May also facilitate integration of nascent murein strands into the sacculus by cleaving the peptide bonds between neighboring strands in mature murein (By similarity)
Thimo_1615	ENOG4105C6T	cysteine synthase
Thimo_1616	ENOG4105BZT	Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity)
Thimo_1617	ENOG4105FNP	Molybdopterin-guanine dinucleotide biosynthesis protein b
Thimo_1619	ENOG4105C0B	DNA polymerase III (alpha subunit)
Thimo_1622	ENOG4105DS7	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity)
Thimo_1623	ENOG4105F03	Provides the (R)-glutamate required for cell wall biosynthesis (By similarity)
Thimo_1628	ENOG4105CW3	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity)
Thimo_1632	ENOG4108V3E	phosphoribosylglycinamide formyltransferase
Thimo_1633	ENOG4105CXB	phosphoribosylaminoimidazole synthetase
Thimo_1634	ENOG4105BZQ	cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase
Thimo_1636	ENOG4105CS1	NAD(P)H quinone oxidoreductase
Thimo_1637	ENOG4105VSY	K01512 acylphosphatase EC 3.6.1.7
Thimo_1640	ENOG4105D1N	poly(r)-hydroxyalkanoic acid synthase, class
Thimo_1641	ENOG4108U4D	synthase) subunit
Thimo_1642	ENOG4105CHU	acetyl-coa acetyltransferase
Thimo_1645	ENOG41069CB	phasin family
Thimo_1646	ENOG4105CHR	reductase
Thimo_1647	ENOG4107QNR	UPF0135 protein
Thimo_1648	ENOG4108R5F	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity)
Thimo_1649	ENOG4105DJ5	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity)
Thimo_1650	ENOG4105EIX	cytochrome c1
Thimo_1651	ENOG4107MKT	Stringent starvation protein a
Thimo_1652	ENOG4105KB2	stringent starvation protein b
Thimo_1658	ENOG4105VEJ	Heat shock protein
Thimo_1659	ENOG4105VW4	glutaredoxin 3
Thimo_1660	ENOG4105CD8	aminopeptidase N
Thimo_1665	ENOG410836F	Transposase
Thimo_1673	ENOG4105CJ1	ABC, transporter
Thimo_1674	ENOG4107QWP	ABC-2 type transporter
Thimo_1675	ENOG4107QWP	ABC-2 type transporter
Thimo_1677	ENOG4105D43	The glycine cleavage system catalyzes the degradation of glycine (By similarity)
Thimo_1678	ENOG4105KE9	The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity)
Thimo_1679	ENOG4107QK8	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
Thimo_1680	ENOG4108V1J	Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity)
Thimo_1681	ENOG4105CBI	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
Thimo_1682	ENOG41080IJ	Diacylglycerol kinase
Thimo_1683	ENOG4108RIR	Molybdenum cofactor biosynthesis protein
Thimo_1684	ENOG4105CVM	Molybdenum cofactor synthesis domain protein
Thimo_1685	ENOG4105M00	molybdopterin converting factor, subunit 1
Thimo_1686	ENOG4106J5J	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity)
Thimo_1687	ENOG4108PXI	ErfK YbiS YcfS YnhG
Thimo_1690	ENOG4105DW3	Response regulator receiver modulated metal dependent phosphohydrolase
Thimo_1691	ENOG4105BZU	Histidine kinase
Thimo_1692	ENOG4105C5C	n-acetylmuramoyl-l-alanine amidase
Thimo_1693	ENOG4105K8N	protein family UPF0079, ATPase
Thimo_1694	ENOG4105DR1	Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity)
Thimo_1695	ENOG4105CDH	Citrulline--aspartate ligase
Thimo_1696	ENOG41080ZE	Adenylate cyclase
Thimo_1697	ENOG4105DEF	Extracellular solute-binding protein, family 5
Thimo_1698	ENOG4105E05	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity)
Thimo_1699	ENOG4105CPP	Dehydrogenase, E1 component
Thimo_1700	ENOG4107RUY	(E1 component), alpha subunit
Thimo_1701	ENOG4105EXG	Transcriptional regulator
Thimo_1703	ENOG4105CM2	brancheD-chain amino acid aminotransferase
Thimo_1704	ENOG4105CE6	Adenylation and deadenylation of glutamate--ammonia ligase (By similarity)
Thimo_1706	ENOG41083WG	hydrogenase assembly chaperone
Thimo_1711	ENOG4105CFV	Tetratricopeptide repeat protein
Thimo_1712	ENOG4106EG9	Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) (By similarity)
Thimo_1713	ENOG4105C3Y	UTP-glucose-1-phosphate uridylyltransferase
Thimo_1714	ENOG4108UTW	Plays a role in the regulation of phosphate uptake
Thimo_1718	ENOG4105VDM	plasmid maintenance system antidote protein, xre family
Thimo_1723	ENOG4105EB3	Histidine kinase
Thimo_1724	ENOG4105XJC	Two component transcriptional regulator (Winged helix family
Thimo_1731	ENOG4105IJJ	transcriptional regulator, crp fnr family
Thimo_1733	ENOG4108UB4	uncharacterized protein ygjQ
Thimo_1734	ENOG4105CBF	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity)
Thimo_1735	ENOG4105D18	nicotinate-nucleotide pyrophosphorylase
Thimo_1740	ENOG4105C75	arginyL-tRNA synthetase
Thimo_1741	ENOG4105DGM	nitrilase cyanide hydratase and apolipoprotein n-acyltransferase
Thimo_1744	ENOG4105VN1	Heat shock protein
Thimo_1760	ENOG4105CY5	solute-binding protein
Thimo_1762	ENOG4108IJ6	ABC transporter
Thimo_1767	ENOG4105DFP	Integrase
Thimo_1779	ENOG4105C0D	helicase
Thimo_1783	ENOG4105DZA	Converts GTP to 7,8-dihydroneopterin triphosphate (By similarity)
Thimo_1784	ENOG4105CTB	Polyprenyl synthetase
Thimo_1785	ENOG41067QG	Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity)
Thimo_1786	ENOG4105C7D	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
Thimo_1788	ENOG4105W4C	monovalent cation H antiporter subunit F
Thimo_1789	ENOG4105SC1	monovalent cation H antiporter subunit E
Thimo_1790	ENOG4107R4Z	monovalent cation h antiporter subunit d
Thimo_1791	ENOG4108ZE9	Monovalent cation H antiporter subunit C
Thimo_1792	ENOG4105D65	subunit l
Thimo_1793	ENOG4105PGM	cation diffusion facilitator family transporter
Thimo_1796	ENOG4105XFK	Ferrous iron transport protein A
Thimo_1800	ENOG4105EUJ	GTP cyclohydrolase i
Thimo_1802	ENOG4107RRY	Cyanophycin synthetase
Thimo_1803	ENOG4105DER	m42 family
Thimo_1804	ENOG4105E06	May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity)
Thimo_1806	ENOG4105EH2	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity)
Thimo_1808	ENOG4105CSM	endonuclease III
Thimo_1810	ENOG4105CD5	CoA-binding domain protein
Thimo_1812	ENOG41082YX	Transcriptional regulator, arsr family
Thimo_1813	ENOG4108UXE	Protein tyrosine phosphatase
Thimo_1814	ENOG4105D6J	arsenicaL-resistance protein
Thimo_1815	ENOG4107S21	permease
Thimo_1818	ENOG4105CHM	Aminotransferase
Thimo_1819	ENOG4105CCW	damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity)
Thimo_1822	ENOG4105EMN	RNA polymerase sigma factor
Thimo_1825	ENOG4105WMJ	Positive regulator of sigma E, RseC MucC
Thimo_1826	ENOG4105C0H	protease
Thimo_1827	ENOG4105C4S	Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity)
Thimo_1828	ENOG4105C3F	Signal peptidase i
Thimo_1830	ENOG4108ZBM	Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity)
Thimo_1832	ENOG41071DT	Involved in DNA repair and RecF pathway recombination (By similarity)
Thimo_1833	ENOG4107QQ4	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity)
Thimo_1839	ENOG4105CFX	Catalyzes the ferrous insertion into protoporphyrin IX (By similarity)
Thimo_1845	ENOG4108YYA	Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity)
Thimo_1846	ENOG4105ECC	imidazole-glycerol-phosphate dehydratase
Thimo_1847	ENOG4105CJV	Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase
Thimo_1848	ENOG4105K8F	Phosphoribosyl-amp cyclohydrolase
Thimo_1849	ENOG4105KPZ	phosphoribosyl-atp pyrophosphatase
Thimo_1850	ENOG4105WKS	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity)
Thimo_1851	ENOG4105X8U	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation (By similarity)
Thimo_1853	ENOG4105DUM	transcriptional regulator, lysR family
Thimo_1856	ENOG4105EHZ	conserved protein UCP016719
Thimo_1861	ENOG4108Z0Z	intracellular protease Pfpi family
Thimo_1864	ENOG4105CF4	DegT DnrJ EryC1 StrS aminotransferase
Thimo_1865	ENOG4108UQS	dipeptidase
Thimo_1868	ENOG4105BZS	acriflavin resistance protein
Thimo_1869	ENOG410624X	efflux transporter, rnd family, mfp subunit
Thimo_1872	ENOG4108YRB	methyltransferase
Thimo_1874	ENOG4108NWD	Cytochrome
Thimo_1876	ENOG4105CMY	5-enolpyruvylshikimate-3-phosphate synthase
Thimo_1877	ENOG4105CAT	Cytidine monophosphate kinase
Thimo_1878	ENOG4105CAV	thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity)
Thimo_1879	ENOG41080YA	This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity)
Thimo_1881	ENOG41080T7	secreted protein
Thimo_1883	ENOG4107SWG	transcriptional regulator MERR family
Thimo_1886	ENOG41082YX	Transcriptional regulator, arsr family
Thimo_1887	ENOG4105DKZ	GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity)
Thimo_1888	ENOG4105CNE	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity)
Thimo_1889	ENOG4105N21	Membrane
Thimo_1890	ENOG4105CUT	histidyl-tRNA synthetase
Thimo_1891	ENOG4105HSZ	Cytoskeletal protein that is involved in cell-shape control through regulation of the length of the long axis (By similarity)
Thimo_1893	ENOG4105C55	Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs
Thimo_1894	ENOG4108UGX	Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity)
Thimo_1895	ENOG4105F7V	ErfK ybiS ycfS ynhG family protein
Thimo_1899	ENOG4107RHB	Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S- adenosylmethionine. Has broad substrate specificity with 6- aminopurine nucleosides as preferred substrates (By similarity)
Thimo_1909	ENOG41082AG	Plasmid maintenance system antidote protein
Thimo_1914	ENOG4105D64	Mechanosensitive ion channel
Thimo_1917	ENOG4108303	d-xylulose 5-phosphate d-fructose 6-phosphate phosphoketolase
Thimo_1919	ENOG4105CQB	FAD linked oxidase domain protein
Thimo_1920	ENOG4105EU8	FAD linked oxidase domain protein
Thimo_1921	ENOG4105CHG	glycolate oxidase (iron-sulfur subunit)
Thimo_1922	ENOG4105C1J	atp-dependent rna helicase
Thimo_1923	ENOG4105VFU	Rna-binding protein
Thimo_1924	ENOG4105C90	Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity)
Thimo_1925	ENOG4108RKI	Necessary for the introduction of cis unsaturation into fatty acids. Catalyzes the dehydration of (3R)-3-hydroxydecanoyl- ACP to E-(2)-decenoyl-ACP and then its isomerization to Z-(3)- decenoyl-ACP. Can catalyze the dehydratase reaction for beta- hydroxyacyl-ACPs with saturated chain lengths up to 16 0, being most active on intermediate chain length (By similarity)
Thimo_1926	ENOG4108JU6	CBS domain protein
Thimo_1929	ENOG4105CKW	Inner membrane protein yedI
Thimo_1930	ENOG4105BZU	Histidine kinase
Thimo_1931	ENOG4105BZS	acriflavin resistance protein
Thimo_1932	ENOG4105C1P	efflux transporter, rnd family, mfp subunit
Thimo_1933	ENOG4105C6K	Malic enzyme
Thimo_1934	ENOG4105C6H	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity)
Thimo_1936	ENOG4107EPV	Aminotransferase class V
Thimo_1939	ENOG4107R5M	Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity)
Thimo_1944	ENOG4105D16	lipopolysaccharide heptosyltransferase i
Thimo_1945	ENOG4107QPH	glycogen) synthase
Thimo_1946	ENOG4105D8A	3-Deoxy-D-manno-octulosonic-acid transferase
Thimo_1948	ENOG4107RIQ	Sulfate adenylate transferase
Thimo_1951	ENOG4105E4C	Lytic transglycosylase catalytic
Thimo_1952	ENOG4105EAQ	(twin-arginine translocation) pathway signal
Thimo_1954	ENOG4106XY2	Folate-binding protein involved in regulating the level of ATP-DnaA and in the modification of some tRNAs. It is probably a key factor in regulatory networks that act via tRNA modification, such as initiation of chromosomal replication (By similarity)
Thimo_1955	ENOG4105CRK	lysyL-tRNA synthetase
Thimo_1957	ENOG4105C8H	hydrogenase maturation protein Hypf
Thimo_1958	ENOG4105CUZ	uba thif-type nad fad binding protein
Thimo_1959	ENOG4105F8V	Hydrolase, tatD family
Thimo_1961	ENOG4105IUQ	nucleoprotein polynucleotide-associated enzyme
Thimo_1964	ENOG4105C5X	domain protein
Thimo_1966	ENOG41081QV	Universal stress protein
Thimo_1967	ENOG4105CER	acetyl-CoA carboxylase biotin carboxylase
Thimo_1968	ENOG4107QSA	Oxaloacetate decarboxylase
Thimo_1973	ENOG410635M	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein (By similarity)
Thimo_1974	ENOG4105E4C	Lytic transglycosylase catalytic
Thimo_1975	ENOG4105C7Q	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity)
Thimo_1976	ENOG4107XU6	Glycosyl transferase (Group 1
Thimo_1995	ENOG4105CQU	Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity)
Thimo_1996	ENOG4105E8T	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG (By similarity)
Thimo_1999	ENOG4105VJP	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell (By similarity)
Thimo_2000	ENOG4107QMS	site-determining protein
Thimo_2001	ENOG4105K7U	Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization (By similarity)
Thimo_2002	ENOG4107YU2	histidine triad (hIT) protein
Thimo_2003	ENOG4105F3K	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity)
Thimo_2004	ENOG4105KDX	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity)
Thimo_2006	ENOG4108IYU	L-aspartate oxidase
Thimo_2007	ENOG4105C5H	ABC transporter
Thimo_2008	ENOG4105BZU	Histidine kinase
Thimo_2012	ENOG4105D1Z	hydroxypyruvate reductase
Thimo_2015	ENOG4105IPI	Membrane
Thimo_2016	ENOG4105BZU	Histidine kinase
Thimo_2017	ENOG4105C9Y	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity)
Thimo_2018	ENOG4107XWB	Zinc finger, swim domain protein
Thimo_2019	ENOG4105C0D	helicase
Thimo_2023	ENOG4105F2I	Transposase
Thimo_2026	ENOG4105C1I	TRANSCRIPTIONAl REGULATOR GntR family
Thimo_2029	ENOG4105J1P	transposase, IS3 IS911 family protein
Thimo_2036	ENOG4105KMG	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes (By similarity)
Thimo_2037	ENOG4105CEN	a g-specific adenine glycosylase
Thimo_2040	ENOG4108IQE	Amp-dependent synthetase and ligase
Thimo_2041	ENOG4105CA8	Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity)
Thimo_2042	ENOG4105CA8	Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity)
Thimo_2043	ENOG4105CZ1	Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity)
Thimo_2044	ENOG4108UCS	ABC, transporter
Thimo_2046	ENOG4105E27	serine threonine protein kinase
Thimo_2055	ENOG4105BZU	Histidine kinase
Thimo_2056	ENOG4105ENT	Efflux transporter rnd family, mfp subunit
Thimo_2059	ENOG4105DX1	Conversion of NADPH, generated by peripheral catabolic pathways, to NADH, which can enter the respiratory chain for energy generation (By similarity)
Thimo_2062	ENOG4105E3W	Two component transcriptional regulator (Winged helix family
Thimo_2063	ENOG4105EB3	Histidine kinase
Thimo_2064	ENOG4105CT7	inner membrane cred family protein
Thimo_2070	ENOG4105CJM	Binding-protein-dependent transport systems, inner membrane component
Thimo_2071	ENOG4105C2T	Binding-protein-dependent transport systems, inner membrane component
Thimo_2072	ENOG4107QPA	Cleaves GlcNAc linked beta-1,4 to MurNAc tripeptides (By similarity)
Thimo_2073	ENOG4108UGV	hypoxanthine phosphoribosyltransferase
Thimo_2076	ENOG4105CJ2	(LipO)protein
Thimo_2077	ENOG4105FE9	pseudouridine synthase
Thimo_2078	ENOG4105C20	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity)
Thimo_2081	ENOG4105CX6	glutaminyL-tRNA synthetase
Thimo_2082	ENOG4105C4P	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity)
Thimo_2084	ENOG4105C1J	atp-dependent rna helicase
Thimo_2085	ENOG4107Y3D	HAD-superfamily hydrolase subfamily IA variant 3
Thimo_2086	ENOG4107RK2	ADP-ribose diphosphatase NudE
Thimo_2089	ENOG4105CCY	NADH flavin oxidoreductase, NADH oxidase
Thimo_2091	ENOG4105K9U	however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity)
Thimo_2092	ENOG4105C2Z	ATP-dependent CLP protease ATP-binding subunit
Thimo_2093	ENOG4105KAE	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation (By similarity)
Thimo_2094	ENOG4105VEQ	Cold shock protein
Thimo_2095	ENOG4105CCJ	Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity)
Thimo_2096	ENOG41075W9	High frequency lysogenization protein HflD homolog
Thimo_2098	ENOG41072GX	Peptidase M22 Glycoprotease
Thimo_2099	ENOG4105DVT	helicase
Thimo_2101	ENOG4105BZ4	penicillin-binding protein
Thimo_2102	ENOG4105E3A	(ABC) transporter
Thimo_2103	ENOG4105DA5	(ABC) transporter
Thimo_2109	ENOG4105D86	that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity)
Thimo_2110	ENOG410626R	Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity)
Thimo_2111	ENOG4108JEB	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity)
Thimo_2124	ENOG4108RH0	Crea protein
Thimo_2128	ENOG4105CJB	Exodeoxyribonuclease I
Thimo_2129	ENOG4108YY1	This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity)
Thimo_2130	ENOG4105D6X	Specifically methylates guanosine-37 in various tRNAs (By similarity)
Thimo_2131	ENOG4108ZR6	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity)
Thimo_2132	ENOG4105K5M	30s ribosomal protein S16
Thimo_2133	ENOG4105CJW	magnesium transporter
Thimo_2134	ENOG4105C1J	atp-dependent rna helicase
Thimo_2135	ENOG4108UPT	UPF0178 protein
Thimo_2142	ENOG4105C5U	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity)
Thimo_2145	ENOG4105BZU	Histidine kinase
Thimo_2155	ENOG4108JQ7	(ABC) transporter
Thimo_2156	ENOG4105C3U	ABC transporter
Thimo_2161	ENOG4105KCK	Peptidoglycan-associated lipoprotein
Thimo_2164	ENOG4105CK7	Sodium proline symporter
Thimo_2165	ENOG4105C1W	two component, sigma54 specific, transcriptional regulator, Fis family
Thimo_2166	ENOG4105BZ1	(ABC) transporter
Thimo_2167	ENOG4107QIM	DNA ligase
Thimo_2170	ENOG4107QI6	Cysteine desulfurase
Thimo_2171	ENOG4105IJJ	transcriptional regulator, crp fnr family
Thimo_2172	ENOG4105D2N	Aldolase
Thimo_2173	ENOG4105CA9	Pyruvate kinase
Thimo_2174	ENOG4105BZA	Phosphoglycerate kinase
Thimo_2175	ENOG4105C17	glyceraldehyde-3-phosphate dehydrogenase
Thimo_2176	ENOG4105CV1	Transketolase (EC 2.2.1.1)
Thimo_2178	ENOG4105CPH	Catalyzes the formation of S-adenosylmethionine from methionine and ATP
Thimo_2179	ENOG4105C3E	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine (By similarity)
Thimo_2180	ENOG4105SYT	Methylenetetrahydrofolate reductase
Thimo_2181	ENOG4105D9M	gamma-glutamylcysteine synthetase
Thimo_2182	ENOG4105CN1	protease
Thimo_2183	ENOG4108Z02	Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity)
Thimo_2185	ENOG4105DBW	Multi-copper polyphenol oxidoreductase laccase
Thimo_2186	ENOG4105C34	Pseudouridine synthase
Thimo_2187	ENOG4106SNF	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
Thimo_2188	ENOG4108YZA	Nitrogen regulatory protein pii
Thimo_2190	ENOG4107TUY	Histidine kinase
Thimo_2191	ENOG4105C1W	two component, sigma54 specific, transcriptional regulator, Fis family
Thimo_2192	ENOG4107QZM	n-acetylglutamate synthase
Thimo_2196	ENOG4108W0I	acetyltransferase
Thimo_2201	ENOG4105KRQ	Addiction module toxin, Txe YoeB family
Thimo_2204	ENOG4105CEH	Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity)
Thimo_2211	ENOG4106N16	had-superfamily hydrolase, subfamily iib
Thimo_2212	ENOG4107RK0	Sucrose phosphorylase
Thimo_2213	ENOG4105VG1	fes assembly suf system protein
Thimo_2214	ENOG4105JRK	feS assembly protein SufD
Thimo_2215	ENOG4105C3K	feS assembly ATPase SufC
Thimo_2218	ENOG4105C5R	Aminotransferase
Thimo_2220	ENOG4105DJ4	phosphatidylserine decarboxylase
Thimo_2221	ENOG4105CAP	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P (By similarity)
Thimo_2222	ENOG4105DRH	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity)
Thimo_2223	ENOG4105CK3	Lysine 2,3-aminomutase YodO family protein
Thimo_2234	ENOG4105D0I	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity)
Thimo_2235	ENOG4105MW3	Cytochrome
Thimo_2236	ENOG4107S7U	Sulfide dehydrogenase
Thimo_2253	ENOG4105J1P	transposase, IS3 IS911 family protein
Thimo_2255	ENOG4105C2Z	ATP-dependent CLP protease ATP-binding subunit
Thimo_2260	ENOG4107QIW	Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity)
Thimo_2262	ENOG4105M56	Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity)
Thimo_2263	ENOG4108JIP	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit (By similarity)
Thimo_2264	ENOG4108JIQ	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit (By similarity)
Thimo_2281	ENOG4105EKE	dihydroorotase
Thimo_2282	ENOG4105DJ1	Phosphoenolpyruvate Carboxylase
Thimo_2283	ENOG4108HWB	Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity)
Thimo_2285	ENOG4105UBK	short-chain dehydrogenase reductase
Thimo_2286	ENOG4108R5F	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity)
Thimo_2287	ENOG4106F3G	Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5- dihydroxy-2-cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon (By similarity)
Thimo_2288	ENOG4108V7X	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
Thimo_2289	ENOG4105C0B	DNA polymerase III (alpha subunit)
Thimo_2292	ENOG4105DW3	Response regulator receiver modulated metal dependent phosphohydrolase
Thimo_2297	ENOG4105CP4	Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity)
Thimo_2299	ENOG4105CHR	reductase
Thimo_2302	ENOG4108ZZ3	UPF0260 protein
Thimo_2315	ENOG4107QYX	exodeoxyribonuclease v alpha
Thimo_2316	ENOG4107QKA	exodeoxyribonuclease V beta
Thimo_2317	ENOG4105DSY	exodeoxyribonuclease V, gamma
Thimo_2319	ENOG4105MYG	DNA polymerase iii, chi subunit
Thimo_2320	ENOG4105BZ6	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity)
Thimo_2323	ENOG4105BZU	Histidine kinase
Thimo_2324	ENOG4108ZXC	Two component transcriptional regulator, luxr family
Thimo_2326	ENOG4105E0I	Catalyzes the formation of N(4)-acetylcytidine (ac(4)C) at the wobble position of tRNA(Met), by using acetyl-CoA as an acetyl donor and ATP (or GTP) (By similarity)
Thimo_2328	ENOG4108MN8	Membrane
Thimo_2330	ENOG4105CGR	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity)
Thimo_2331	ENOG4105C2N	RNA methyltransferase TrmH family group 3
Thimo_2332	ENOG4105C40	3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity)
Thimo_2334	ENOG4105BZU	Histidine kinase
Thimo_2335	ENOG4105WH1	Two component transcriptional regulator luxr family
Thimo_2339	ENOG4105D4U	had-superfamily hydrolase, subfamily iia
Thimo_2340	ENOG4105NPQ	Pfam:DUF403
Thimo_2343	ENOG4105C9C	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity)
Thimo_2344	ENOG4105K63	Thioredoxin
Thimo_2345	ENOG4105K63	Thioredoxin
Thimo_2347	ENOG4107Z6W	Protein CrcB homolog
Thimo_2348	ENOG4108YZN	class I peptide chain release factor
Thimo_2349	ENOG4106PT6	cdpdiacylglycerol-serine O-phosphatidyltransferase
Thimo_2350	ENOG4105GKE	subunit e
Thimo_2351	ENOG4107QIZ	NADH dehydrogenase
Thimo_2358	ENOG4108RAV	Conserved protein
Thimo_2360	ENOG4105E0F	Histidine kinase
Thimo_2361	ENOG4105DPZ	Two component transcriptional regulator (Winged helix family
Thimo_2363	ENOG4105CQ3	Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity)
Thimo_2365	ENOG4108JA2	transcriptioN-repair coupling factor
Thimo_2367	ENOG41082J7	Rhodanese domain protein
Thimo_2368	ENOG4105E26	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity)
Thimo_2369	ENOG4108UMW	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity)
Thimo_2370	ENOG4105D1A	Methyltransferase
Thimo_2371	ENOG4105C01	Dihydroxy-acid dehydratase
Thimo_2372	ENOG4105F8V	Hydrolase, tatD family
Thimo_2374	ENOG4107QRG	dna polymerase iii
Thimo_2375	ENOG4108ZMD	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity)
Thimo_2376	ENOG4105HHA	aminodeoxychorismate lyase
Thimo_2378	ENOG4105C0Q	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity)
Thimo_2379	ENOG4105VNB	Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity)
Thimo_2380	ENOG4105CHR	reductase
Thimo_2381	ENOG4105CJF	Malonyl coA-acyl carrier protein transacylase
Thimo_2382	ENOG4105CCZ	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity)
Thimo_2383	ENOG4105C6B	Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA (By similarity)
Thimo_2384	ENOG4105VGS	50s ribosomal protein l32
Thimo_2385	ENOG4105FCQ	metal-binding, possibly nucleic acid-binding protein
Thimo_2386	ENOG4105C91	Plays an important role in the de novo pathway of purine nucleotide biosynthesis
Thimo_2387	ENOG4105C49	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine (By similarity)
Thimo_2389	ENOG4105EPW	hflc protein
Thimo_2390	ENOG4107QJR	hflk protein
Thimo_2391	ENOG4105C1N	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity)
Thimo_2392	ENOG4105KW8	RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity)
Thimo_2393	ENOG4105DKX	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity)
Thimo_2394	ENOG4105DC6	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity)
Thimo_2397	ENOG4105C25	Primosomal protein n'
Thimo_2401	ENOG4105UYK	outer membrane protein a
Thimo_2403	ENOG4105KJM	monovalent cation h antiporter subunit g
Thimo_2406	ENOG4108ZE9	Monovalent cation H antiporter subunit C
Thimo_2407	ENOG4108JPZ	Monovalent cation H antiporter subunit D
Thimo_2408	ENOG4108JPZ	Monovalent cation H antiporter subunit D
Thimo_2410	ENOG4105ES3	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
Thimo_2412	ENOG4105CQV	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
Thimo_2414	ENOG4105SC1	monovalent cation H antiporter subunit E
Thimo_2416	ENOG4106D4I	domain protein
Thimo_2417	ENOG4107VRP	DNA repair exonuclease
Thimo_2424	ENOG4105C9B	Cysteine desulfurase
Thimo_2426	ENOG4105VM8	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding (By similarity)
Thimo_2427	ENOG4105CFH	Aspartokinase
Thimo_2428	ENOG4105CIM	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity)
Thimo_2429	ENOG4105Y3E	Modulates RecA activity (By similarity)
Thimo_2430	ENOG4105C68	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity)
Thimo_2432	ENOG4107TH8	cina domain protein
Thimo_2434	ENOG4108EX3	reductase
Thimo_2436	ENOG4105CVP	deoxyribo-dipyrimidine photolyase
Thimo_2437	ENOG4108R96	Methyltransferase, YaeB family
Thimo_2438	ENOG4108USZ	hydrogenase
Thimo_2442	ENOG4108Z66	YbaK ebsC protein
Thimo_2444	ENOG4105D1H	recombination factor protein RarA
Thimo_2445	ENOG4107Y7W	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane) (By similarity)
Thimo_2446	ENOG4105CNU	cell division protein FtsK
Thimo_2447	ENOG4105C3M	thioredoxin reductase
Thimo_2449	ENOG4108R4Z	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine (By similarity)
Thimo_2450	ENOG4105DWA	May conjugate Arg from its aminoacyl-tRNA to the N- termini of proteins containing an N-terminal aspartate or glutamate
Thimo_2451	ENOG4105C3B	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity)
Thimo_2452	ENOG4108ETH	Formylglycinamide ribotide synthetase
Thimo_2461	ENOG4105CBM	Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 (By similarity)
Thimo_2462	ENOG4105BZU	Histidine kinase
Thimo_2466	ENOG4108ZXC	Two component transcriptional regulator, luxr family
Thimo_2470	ENOG4105EXU	Membrane
Thimo_2473	ENOG4105IPI	Membrane
Thimo_2482	ENOG4105K3G	Periplasmic Protein
Thimo_2488	ENOG4105E2V	Glycosyltransferase 36
Thimo_2489	ENOG4105BZU	Histidine kinase
Thimo_2490	ENOG4105BZU	Histidine kinase
Thimo_2491	ENOG4105C48	Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity)
Thimo_2492	ENOG4105MWK	D-amino acid dehydrogenase, small subunit
Thimo_2498	ENOG4109015	Biopolymer transport protein exbD tolR
Thimo_2500	ENOG4105D05	Receptor
Thimo_2501	ENOG4105CKI	cobalamin synthesis protein
Thimo_2509	ENOG4105MYN	Zinc uptake regulation protein
Thimo_2511	ENOG4105DIK	(ABC) transporter
Thimo_2513	ENOG4108V7X	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
Thimo_2521	ENOG4105D6C	Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity)
Thimo_2525	ENOG4108UTW	Plays a role in the regulation of phosphate uptake
Thimo_2526	ENOG4105BZY	Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity)
Thimo_2528	ENOG4105C8U	phosphate abc transporter
Thimo_2530	ENOG4105CJW	magnesium transporter
Thimo_2531	ENOG4105CG6	trap dicarboxylate transporter dctm subunit
Thimo_2532	ENOG410835K	Tripartite ATP-Independent Periplasmic transporter DctQ
Thimo_2533	ENOG4105DR6	Trap dicarboxylate transporter, dctp subunit
Thimo_2534	ENOG4105DUK	Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity)
Thimo_2535	ENOG4105BZ5	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity)
Thimo_2536	ENOG4105CFG	Acts as a chaperone (By similarity)
Thimo_2537	ENOG4105K90	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
Thimo_2538	ENOG4105CI8	Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons (By similarity)
Thimo_2539	ENOG4105F91	Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity)
Thimo_2540	ENOG4105C4F	May be involved in recombinational repair of damaged DNA (By similarity)
Thimo_2541	ENOG41090R7	Ferric uptake
Thimo_2542	ENOG4105YRI	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity)
Thimo_2543	ENOG4105VDB	UPF0125 protein
Thimo_2544	ENOG4108Z1B	Cyclase dehydrase
Thimo_2545	ENOG4105C8J	)-transporter
Thimo_2546	ENOG4107QJF	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity)
Thimo_2547	ENOG4105EEI	dihydropteroate synthase
Thimo_2548	ENOG4105C3H	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity)
Thimo_2549	ENOG4105F7M	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit (By similarity)
Thimo_2550	ENOG4105D7Z	glutathione synthase
Thimo_2553	ENOG4108UJU	UPF0301 protein
Thimo_2554	ENOG4107Y66	Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity)
Thimo_2555	ENOG4108UK1	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant (By similarity)
Thimo_2556	ENOG4105CXT	aspartate transcarbamylase
Thimo_2557	ENOG4105CD3	dihydroorotase
Thimo_2563	ENOG4105DP5	Catalyzes the biosynthesis of agmatine from arginine (By similarity)
Thimo_2564	ENOG4105WMM	Probably plays a role in a hydrogenase nickel cofactor insertion step (By similarity)
Thimo_2576	ENOG41071TK	Uncharacterised protein family (UPF0150)
Thimo_2579	ENOG4105C8A	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP (By similarity)
Thimo_2580	ENOG4105CFB	Gamma-glutamyltranspeptidase (EC 2.3.2.2)
Thimo_2582	ENOG4105C5H	ABC transporter
Thimo_2583	ENOG4105D64	Mechanosensitive ion channel
Thimo_2584	ENOG4105C5U	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity)
Thimo_2588	ENOG4106RE7	Cytochrome
Thimo_2592	ENOG4105C2M	dna polymerase I
Thimo_2593	ENOG4105WH1	Two component transcriptional regulator luxr family
Thimo_2597	ENOG410600T	transposase
Thimo_2598	ENOG4108UXA	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity)
Thimo_2599	ENOG4108Z03	MAF-like protein
Thimo_2600	ENOG4105C03	ribonuclease
Thimo_2604	ENOG4105D1U	peptidase U62 modulator of DNA gyrase
Thimo_2605	ENOG4105CMS	peptidase U62, modulator of DNA gyrase
Thimo_2607	ENOG4108RAC	Rubrerythrin
Thimo_2608	ENOG4108UVJ	appr-1-p processing domain protein
Thimo_2609	ENOG4105KA7	cytochrome C
Thimo_2617	ENOG4105CII	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity)
Thimo_2629	ENOG4105DHP	deoxycytidine triphosphate deaminase
Thimo_2630	ENOG4105CZI	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
Thimo_2637	ENOG4108ZCA	Inherit from COG: pyridine nucleotide-disulfide oxidoreductase
Thimo_2638	ENOG41082K8	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Interacts with IscS and stimulates its activity. Then, accepts a sulfur from IscS and transfers it in turn to TusD (By similarity)
Thimo_2639	ENOG41082J7	Rhodanese domain protein
Thimo_2640	ENOG4105CB8	Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity)
Thimo_2641	ENOG4105DWR	Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity)
Thimo_2642	ENOG4105C28	cystathionine
Thimo_2643	ENOG4105CBA	glutamine phosphoribosylpyrophosphate amidotransferase
Thimo_2644	ENOG4105E96	Colicin v production protein
Thimo_2646	ENOG4105DPM	folylpolyglutamate synthase Dihydrofolate synthase
Thimo_2647	ENOG4107QTG	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA (By similarity)
Thimo_2648	ENOG4105F6H	The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity)
Thimo_2649	ENOG4105CG0	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity)
Thimo_2650	ENOG4108ZGB	N-(5'-phosphoribosyl)anthranilate isomerase
Thimo_2651	ENOG4105DI7	Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity)
Thimo_2653	ENOG4105CM3	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity)
Thimo_2654	ENOG4105C0C	Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity)
Thimo_2655	ENOG4105MQS	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity)
Thimo_2656	ENOG4105CQI	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity)
Thimo_2657	ENOG4105KQV	Binds directly to 16S ribosomal RNA (By similarity)
Thimo_2663	ENOG4105BZ5	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity)
Thimo_2665	ENOG4107YJ4	chain length determinant protein
Thimo_2676	ENOG4105ESV	Glycosyl transferase, family 4
Thimo_2677	ENOG4105DXD	2-methylcitrate dehydratase
Thimo_2678	ENOG4105BZN	citrate synthase
Thimo_2679	ENOG4105CR4	methylisocitrate lyase
Thimo_2680	ENOG4105DRR	Transcriptional regulator, GntR family
Thimo_2681	ENOG4108IQF	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity)
Thimo_2693	ENOG4105BZU	Histidine kinase
Thimo_2695	ENOG4107SC1	transglycosylase
Thimo_2698	ENOG4105F8C	transglutaminase domain-containing protein
Thimo_2700	ENOG4107QW3	Sucrose phosphorylase
Thimo_2701	ENOG4105N1F	Hnh endonuclease
Thimo_2702	ENOG4105CA0	peroxidase
Thimo_2704	ENOG4107QYG	anthranilate phosphoribosyltransferase
Thimo_2710	ENOG4105C3J	Cysteine desulfurase
Thimo_2713	ENOG4105EYH	Exonuclease
Thimo_2717	ENOG4105EYH	Exonuclease
Thimo_2721	ENOG4107SCJ	type I restriction enzyme EcoKI subunit R
Thimo_2734	ENOG4108V0P	LemA family
Thimo_2736	ENOG4105CKJ	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity)
Thimo_2738	ENOG4105C09	Bile acid
Thimo_2740	ENOG4105CMR	udp-glucose 4-epimerase
Thimo_2747	ENOG4105CIH	Imidazole acetol-phosphate transaminase
Thimo_2748	ENOG4105CEK	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity)
Thimo_2749	ENOG4105E21	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity)
Thimo_2750	ENOG4105CDF	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity)
Thimo_2753	ENOG4107PE3	Mammalian cell entry related domain protein
Thimo_2754	ENOG4105CY3	ABC transporter, permease
Thimo_2755	ENOG4105DHJ	ABC, transporter
Thimo_2756	ENOG4105C2X	Arabinose 5-phosphate isomerase
Thimo_2757	ENOG4108Z4R	3-deoxy-d-manno-octulosonate 8-phosphate phosphatase
Thimo_2760	ENOG4108IUZ	ABC transporter
Thimo_2761	ENOG4105DTW	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity)
Thimo_2762	ENOG41080QH	sigma 54 modulation protein ribosomal protein S30EA
Thimo_2763	ENOG4107RM2	PTS IIA-like nitrogen-regulatory protein PtsN
Thimo_2765	ENOG4105C21	Displays ATPase and GTPase activities (By similarity)
Thimo_2767	ENOG41080Z8	PHOSPHOCARRIER protein
Thimo_2768	ENOG4105BZ3	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity)
Thimo_2770	ENOG4105D4D	transcriptional regulator
Thimo_2772	ENOG4105CTK	cobaltochelatase, cobn subunit
Thimo_2775	ENOG4105XPQ	lipid carrier protein
Thimo_2776	ENOG4108BDP	Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity)
Thimo_2777	ENOG4105DZ1	carboxypeptidase
Thimo_2778	ENOG4105K6T	rare lipoprotein A
Thimo_2779	ENOG4105CVE	Lytic murein transglycosylase
Thimo_2780	ENOG4105CNI	cell division protein FtsW
Thimo_2781	ENOG4105CJN	penicillin-binding protein
Thimo_2782	ENOG4105VQ7	Rod shape-determining protein MreD
Thimo_2783	ENOG4105N3I	Involved in formation and maintenance of cell shape (By similarity)
Thimo_2784	ENOG4105DFF	Rod shape-determining protein mreb
Thimo_2785	ENOG41080G2	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity)
Thimo_2786	ENOG4105C3P	Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity)
Thimo_2787	ENOG4105CHT	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity)
Thimo_2790	ENOG4105D4P	Coproporphyrinogen iii oxidase
Thimo_2791	ENOG4105I29	Bacteriochlorophyll 4-vinyl reductase
Thimo_2793	ENOG4105D9I	Responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6 (By similarity)
Thimo_2795	ENOG4105CWC	Acetylornithine deacetylase
Thimo_2796	ENOG4105CEJ	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity)
Thimo_2805	ENOG4105EHG	Permease protein
Thimo_2807	ENOG4105E0A	ABC, transporter
Thimo_2808	ENOG4107T6J	Ribulose-1,5-bisphosphate carboxylase oxygenase large subunit
Thimo_2809	ENOG4106RE7	Cytochrome
Thimo_2810	ENOG4106RE7	Cytochrome
Thimo_2814	ENOG4105MRR	Transcriptional regulator (By similarity)
Thimo_2815	ENOG4105BZU	Histidine kinase
Thimo_2816	ENOG4105BZU	Histidine kinase
Thimo_2817	ENOG4105BZU	Histidine kinase
Thimo_2818	ENOG4107X2D	transcriptional regulator, merr family
Thimo_2819	ENOG4105F37	PsaA and PsaB bind P700, the primary electron donor of photosystem I (PSI), as well as the electron acceptors A0, A1 and FX. PSI is a plastocyanin cytochrome c6-ferredoxin oxidoreductase, converting photonic excitation into a charge separation, which transfers an electron from the donor P700 chlorophyll pair to the spectroscopically characterized acceptors A0, A1, FX, FA and FB in turn. Oxidized P700 is reduced on the lumenal side of the thylakoid membrane by plastocyanin or cytochrome c6
Thimo_2820	ENOG4105BZ1	(ABC) transporter
Thimo_2821	ENOG4105WJX	transcriptional regulator MERR family
Thimo_2822	ENOG4108ZUF	This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity)
Thimo_2823	ENOG4105C6A	phenylalanyl-tRNA synthetase (beta subunit)
Thimo_2824	ENOG4105CSS	phenylalanyl-tRNA synthetase (alpha subunit)
Thimo_2825	ENOG4108YZX	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity)
Thimo_2826	ENOG41082NX	50s ribosomal protein l35
Thimo_2828	ENOG4105C22	threonyL-tRNA synthetase
Thimo_2830	ENOG4107GFK	fumarate
Thimo_2833	ENOG4108ZT0	50S ribosomal protein l17
Thimo_2834	ENOG4105CTF	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
Thimo_2835	ENOG4105G6W	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity)
Thimo_2836	ENOG4108UHH	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity)
Thimo_2837	ENOG4108Z04	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
Thimo_2839	ENOG41067V7	50S ribosomal protein L36
Thimo_2840	ENOG4105CGG	The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity)
Thimo_2841	ENOG4108UZ0	Binds to the 23S rRNA (By similarity)
Thimo_2842	ENOG4105VPB	50S ribosomal protein L30
Thimo_2843	ENOG4108RA9	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity)
Thimo_2844	ENOG4105K4C	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity)
Thimo_2845	ENOG4108R5J	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity)
Thimo_2846	ENOG4108UJY	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity)
Thimo_2847	ENOG4105VBI	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity)
Thimo_2848	ENOG4105CW6	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
Thimo_2849	ENOG4105KAR	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity)
Thimo_2850	ENOG4108UNN	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity)
Thimo_2851	ENOG4105K87	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal
Thimo_2852	ENOG41083MP	50s ribosomal protein l29
Thimo_2853	ENOG4108R70	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity)
Thimo_2854	ENOG4105CKE	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity)
Thimo_2855	ENOG4105KAP	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity)
Thimo_2856	ENOG4105K7S	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity)
Thimo_2857	ENOG4105CFD	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
Thimo_2858	ENOG41080KG	One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity)
Thimo_2859	ENOG4106U5A	One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity)
Thimo_2860	ENOG4105EEE	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity)
Thimo_2861	ENOG4108Z10	Involved in the binding of tRNA to the ribosomes (By similarity)
Thimo_2862	ENOG4105CGV	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity)
Thimo_2863	ENOG4105CEJ	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity)
Thimo_2864	ENOG4108UHY	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity)
Thimo_2865	ENOG4108UKE	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity)
Thimo_2866	ENOG4105D27	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
Thimo_2867	ENOG4107QIH	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
Thimo_2868	ENOG4105KBC	Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity)
Thimo_2869	ENOG4108VZM	50s ribosomal protein L10
Thimo_2870	ENOG4105C64	Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity)
Thimo_2871	ENOG4108UIK	This protein binds directly to 23S ribosomal RNA (By similarity)
Thimo_2872	ENOG4105E5V	Participates in transcription elongation, termination and antitermination (By similarity)
Thimo_2873	ENOG4105PM1	preprotein translocase subunit SecE
Thimo_2875	ENOG4105CGV	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity)
Thimo_2879	ENOG4105C6Y	Udp-glucose 6-dehydrogenase
Thimo_2883	ENOG4108HMN	Caspase domain
Thimo_2885	ENOG4108UK5	Transposase
Thimo_2887	ENOG4108HMN	Caspase domain
Thimo_2888	ENOG4105D1X	Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity)
Thimo_2889	ENOG4105C6P	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity)
Thimo_2890	ENOG4105CNW	domain protein
Thimo_2900	ENOG4105C59	p-type ATPase
Thimo_2903	ENOG4108RS6	transposase
Thimo_2905	ENOG4108S7T	Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP) (By similarity)
Thimo_2907	ENOG4108VKV	Monofunctional biosynthetic peptidoglycan transglycosylase
Thimo_2915	ENOG4105CUU	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity)
Thimo_2916	ENOG4108YXG	UPF0502 protein
Thimo_2917	ENOG4107GZ4	SanA protein
Thimo_2920	ENOG4105CHQ	Murein-degrading enzyme that degrades murein glycan strands and insoluble, high-molecular weight murein sacculi, with the concomitant formation of a 1,6-anhydromuramoyl product. Lytic transglycosylases (LTs) play an integral role in the metabolism of the peptidoglycan (PG) sacculus. Their lytic action creates space within the PG sacculus to allow for its expansion as well as for the insertion of various structures such as secretion systems and flagella (By similarity)
Thimo_2921	ENOG4105BZU	Histidine kinase
Thimo_2930	ENOG4107QVM	von Willebrand factor, type A
Thimo_2934	ENOG4105C7R	Atpase associated with various cellular activities aaa_3
Thimo_2935	ENOG4105E26	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity)
Thimo_2940	ENOG4108ZG0	Ompa motb domain protein
Thimo_2944	ENOG4105DUM	transcriptional regulator, lysR family
Thimo_2945	ENOG4108TWJ	NADH dehydrogenase subunit 5
Thimo_2946	ENOG4105EVH	UPF0753 protein
Thimo_2947	ENOG4105DT1	RuBisCO catalyzes two reactions the carboxylation of D- ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate
Thimo_2948	ENOG4108VFZ	ribulose bisphosphate carboxylase, small
Thimo_2953	ENOG4105KNY	Microcompartments protein
Thimo_2954	ENOG4105KNY	Microcompartments protein
Thimo_2958	ENOG4105DUM	transcriptional regulator, lysR family
Thimo_2962	ENOG4108JJ7	ABC transporter
Thimo_2964	ENOG4105GJM	(LipO)protein
Thimo_2965	ENOG4105CDP	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity)
Thimo_2966	ENOG4105RH4	Glycine cleavage system transcriptional repressor
Thimo_2967	ENOG4108YXY	alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
Thimo_2968	ENOG4108IAB	Phoh family
Thimo_2969	ENOG4108Z33	Thiol disulfide Interchange Protein
Thimo_2970	ENOG4107ZIF	6-carboxy-5,6,7,8-tetrahydropterin synthase
Thimo_2971	ENOG4105FD2	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity)
Thimo_2974	ENOG4108UUM	single-stranded DNA-binding protein
Thimo_2975	ENOG4107RDB	Major Facilitator
Thimo_2976	ENOG4105XUA	cytochrome c
Thimo_2988	ENOG4105ZA6	Antenna complexes are light-harvesting systems, which transfer the excitation energy to the reaction centers (By similarity)
Thimo_2991	ENOG4105ZA6	Antenna complexes are light-harvesting systems, which transfer the excitation energy to the reaction centers (By similarity)
Thimo_2993	ENOG4105ZA6	Antenna complexes are light-harvesting systems, which transfer the excitation energy to the reaction centers (By similarity)
Thimo_2995	ENOG4105ZA6	Antenna complexes are light-harvesting systems, which transfer the excitation energy to the reaction centers (By similarity)
Thimo_2996	ENOG4105J6N	PhotosynthetiC reaction center cytochrome c subunit
Thimo_2997	ENOG4107R94	photosynthetic reaction center, M subunit
Thimo_2998	ENOG4105VGZ	photosynthetic reaction center L subunit
Thimo_3000	ENOG4105ZA6	Antenna complexes are light-harvesting systems, which transfer the excitation energy to the reaction centers (By similarity)
Thimo_3001	ENOG41068GY	Antenna complexes are light-harvesting systems, which transfer the excitation energy to the reaction centers (By similarity)
Thimo_3002	ENOG4105ZA6	Antenna complexes are light-harvesting systems, which transfer the excitation energy to the reaction centers (By similarity)
Thimo_3004	ENOG41060GA	Chlorophyllide reductase subunit Y
Thimo_3005	ENOG4105DSM	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex, which has 2 components the iron protein and the molybdenum-iron protein (By similarity)
Thimo_3006	ENOG4107XHQ	chlorophyll synthesis pathway, bchC
Thimo_3007	ENOG4107EPK	O-methyltransferase, family 2
Thimo_3008	ENOG4105CTB	Polyprenyl synthetase
Thimo_3011	ENOG4105FE1	phytoene synthase
Thimo_3012	ENOG4105EWK	phytoene
Thimo_3013	ENOG4105D3C	The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity)
Thimo_3014	ENOG4107SV1	subunit D
Thimo_3016	ENOG4108TF2	Photosynthetic complex assembly protein 2
Thimo_3021	ENOG4108MIC	Mg-protoporphyrin IX methyl transferase
Thimo_3022	ENOG4105DSM	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex, which has 2 components the iron protein and the molybdenum-iron protein (By similarity)
Thimo_3023	ENOG4105CTK	cobaltochelatase, cobn subunit
Thimo_3024	ENOG4105EVY	Uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent (By similarity)
Thimo_3025	ENOG4105C78	Uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent (By similarity)
Thimo_3026	ENOG4108VJI	2-vinyl bacteriochlorophyllide hydratase
Thimo_3029	ENOG4105D3C	The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity)
Thimo_3030	ENOG4107EEK	Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity)
Thimo_3031	ENOG4105CZF	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity)
Thimo_3032	ENOG4108R99	pseudouridine synthase
Thimo_3039	ENOG4108J5G	6-phosphogluconate dehydrogenase
Thimo_3040	ENOG4105DCF	alanine dehydrogenase
Thimo_3042	ENOG4105CJX	Molecular chaperone. Has ATPase activity (By similarity)
Thimo_3043	ENOG4107QIX	Phosphoglucomutase (EC 5.4.2.2
Thimo_3044	ENOG4105C3H	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity)
Thimo_3046	ENOG4105EJF	Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity)
Thimo_3047	ENOG4105C9M	aspartyl-trna synthetase
Thimo_3050	ENOG41074MP	UPF0103 Mediator of ErbB2-driven cell motility-containing protein
Thimo_3053	ENOG4108URP	Dtdp-4-dehydrorhamnose 3,5-epimerase
Thimo_3057	ENOG4105D3Q	Sugar transferase
Thimo_3070	ENOG4107XU6	Glycosyl transferase (Group 1
Thimo_3071	ENOG4108SHN	Glycosyl transferase, family 2
Thimo_3076	ENOG4105PSV	Polysaccharide Biosynthesis Protein
Thimo_3084	ENOG4105C1W	two component, sigma54 specific, transcriptional regulator, Fis family
Thimo_3085	ENOG4105E4C	Lytic transglycosylase catalytic
Thimo_3092	ENOG4105DJQ	tetratricopeptide tpr_2 repeat protein
Thimo_3097	ENOG4105E99	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity)
Thimo_3098	ENOG4105C9U	ATP-dependent DNA helicase RecQ
Thimo_3101	ENOG4105EYM	Major Facilitator superfamily
Thimo_3102	ENOG4105DH7	May be involved in recombination (By similarity)
Thimo_3104	ENOG4105C7C	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity)
Thimo_3105	ENOG4105CDK	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity)
Thimo_3106	ENOG4105CIT	This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity)
Thimo_3107	ENOG4105K7E	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly (By similarity)
Thimo_3108	ENOG4105CPF	Cell wall formation (By similarity)
Thimo_3109	ENOG4105D4A	Cell wall formation (By similarity)
Thimo_3110	ENOG4105DFU	Cell wall formation (By similarity)
Thimo_3111	ENOG4105DVQ	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity)
Thimo_3112	ENOG4105CNI	cell division protein FtsW
Thimo_3113	ENOG4105DMZ	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity)
Thimo_3114	ENOG4105CPY	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity)
Thimo_3115	ENOG4108EQQ	Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein (By similarity)
Thimo_3116	ENOG4107EEN	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity)
Thimo_3117	ENOG4105CJN	penicillin-binding protein
Thimo_3118	ENOG41063Y6	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic (By similarity)
Thimo_3119	ENOG4105CGJ	Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity)
Thimo_3122	ENOG4105GN9	Joins Ado-cobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin) (By similarity)
Thimo_3123	ENOG4108TGR	phosphatase
Thimo_3124	ENOG4108YXN	Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity)
Thimo_3125	ENOG4105CJ1	ABC, transporter
Thimo_3127	ENOG4105D06	uba thif-type nad fad binding protein
Thimo_3129	ENOG4105EQY	Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity)
Thimo_3130	ENOG4105C8K	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity)
Thimo_3131	ENOG4105C7E	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity)
Thimo_3132	ENOG4105DJQ	tetratricopeptide tpr_2 repeat protein
Thimo_3133	ENOG4105CTR	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity)
Thimo_3135	ENOG4105C5T	Phosphoribosyl pyrophosphate synthase
Thimo_3136	ENOG4105KW6	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity)
Thimo_3137	ENOG4108ZPD	The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity)
Thimo_3138	ENOG4105CMR	udp-glucose 4-epimerase
Thimo_3141	ENOG4105BZU	Histidine kinase
Thimo_3142	ENOG4105E3W	Two component transcriptional regulator (Winged helix family
Thimo_3143	ENOG4105C1P	efflux transporter, rnd family, mfp subunit
Thimo_3144	ENOG4105BZS	acriflavin resistance protein
Thimo_3145	ENOG4105ENJ	RND efflux system, outer membrane lipoprotein
Thimo_3148	ENOG4105MRD	Phage derived protein Gp49-like (DUF891)
Thimo_3151	ENOG4105C4R	Atp-dependent dna helicase
Thimo_3154	ENOG4105DKZ	GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity)
Thimo_3156	ENOG4108UT2	hemolysin iii
Thimo_3157	ENOG4105CJ1	ABC, transporter
Thimo_3160	ENOG4105DKJ	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity)
Thimo_3161	ENOG4105BZU	Histidine kinase
Thimo_3171	ENOG4105CQ7	ATP-dependent helicase
Thimo_3172	ENOG4105DN3	alpha-2-macroglobulin domain protein
Thimo_3173	ENOG4108JQB	penicillin-binding protein 1C
Thimo_3180	ENOG4105C53	Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity)
Thimo_3181	ENOG4105E0C	molybdate abc transporter
Thimo_3185	ENOG4105WQ5	TonB family
Thimo_3186	ENOG4108ZZF	transport protein (ExbD)
Thimo_3189	ENOG4105CHI	Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB (By similarity)
Thimo_3191	ENOG4105EIE	fructose-bisphosphate aldolase
Thimo_3193	ENOG4105K8R	UPF0145 protein
Thimo_3197	ENOG4105XJC	Two component transcriptional regulator (Winged helix family
Thimo_3200	ENOG4105F0V	Cell wall hydrolase
Thimo_3203	ENOG4108JPZ	Monovalent cation H antiporter subunit D
Thimo_3204	ENOG4107TDF	Formate hydrogenlyase subunit 4
Thimo_3206	ENOG4108JPZ	Monovalent cation H antiporter subunit D
Thimo_3207	ENOG4105CQV	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
Thimo_3208	ENOG4105C47	NADH ubiquinone oxidoreductase 20 kda subunit
Thimo_3227	ENOG4107QUV	Domain protein
Thimo_3228	ENOG4105CHR	reductase
Thimo_3232	ENOG410605C	May protect the nitrogenase Fe-Mo protein from oxidative damage (By similarity)
Thimo_3234	ENOG4105CYQ	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity)
Thimo_3240	ENOG4105FZE	dinitrogenase iron-molybdenum cofactor biosynthesis
Thimo_3241	ENOG4107IVC	4Fe-4S ferredoxin, iron-sulfur binding
Thimo_3242	ENOG41084IN	nitrogen fixation protein
Thimo_3243	ENOG4105CY9	nitrogenase molybdenum-iron protein beta chain
Thimo_3244	ENOG4105D0B	Nitrogenase protein alpha chain
Thimo_3245	ENOG4105DSM	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex, which has 2 components the iron protein and the molybdenum-iron protein (By similarity)
Thimo_3246	ENOG4108K8Z	nad( )--dinitrogen-reductase ADP-d-ribosyltransferase
Thimo_3248	ENOG4105CGC	Nitrogenase cofactor biosynthesis protein NifB
Thimo_3249	ENOG4105P1D	4fe-4s ferredoxin, iron-sulfur binding
Thimo_3250	ENOG4105CNW	domain protein
Thimo_3251	ENOG4105KXW	Ferredoxin
Thimo_3252	ENOG4105U82	Ferredoxin
Thimo_3253	ENOG4105PS4	nifq family
Thimo_3254	ENOG41065RQ	ADP-ribosylation crystallin J1
Thimo_3255	ENOG4105BZU	Histidine kinase
Thimo_3259	ENOG4105C6K	Malic enzyme
Thimo_3261	ENOG4108HWB	Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity)
Thimo_3262	ENOG4105DDT	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity)
Thimo_3263	ENOG4105NWN	ApaG protein
Thimo_3266	ENOG4105DBD	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation (By similarity)
Thimo_3267	ENOG4105E7H	involved in the assembly of LPS in the outer leaflet of the outer membrane. Determines N-hexane tolerance and is involved in outer membrane permeability. Essential for envelope biogenesis (By similarity)
Thimo_3268	ENOG4105C45	hydrogenase expression formation protein (HypE)
Thimo_3269	ENOG4105CQS	hydrogenase expression formation protein HypD
Thimo_3271	ENOG4105J8R	Hydrogenase expression formation protein
Thimo_3272	ENOG4107Y49	methyltransferase
Thimo_3274	ENOG4105E4Z	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity)
Thimo_3275	ENOG4105CT0	Protein of unknown function, DUF484
Thimo_3276	ENOG4108IYS	Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity)
Thimo_3279	ENOG4105C4N	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis (By similarity)
Thimo_3280	ENOG41089UC	methyltransferase, type 11
Thimo_3283	ENOG4105C8Y	Acetylornithine aminotransferase
Thimo_3284	ENOG4105DBV	ornithine carbamoyltransferase
Thimo_3288	ENOG4105C0R	drug resistance transporter emrb qaca subfamily
Thimo_3289	ENOG4105CGD	Nad-dependent epimerase dehydratase
Thimo_3295	ENOG41065SU	Two-component system sensor kinase
Thimo_3296	ENOG4105BZU	Histidine kinase
Thimo_3297	ENOG4105CK6	Two component transcriptional regulator (Winged helix family
Thimo_3298	ENOG4107YM4	Beta-lactamase domain-containing protein
Thimo_3299	ENOG4108YZ4	nudix hydrolase
Thimo_3300	ENOG4105P9C	Participates in cysteine desulfuration mediated by SufS. Cysteine desulfuration mobilizes sulfur from L-cysteine to yield L-alanine and constitutes an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules. Functions as a sulfur acceptor for SufS, by mediating the direct transfer of the sulfur atom from the S-sulfanylcysteine of SufS, an intermediate product of cysteine desulfuration process (By similarity)
Thimo_3301	ENOG4108Z4V	iron-sulfur cluster assembly
Thimo_3302	ENOG4108V0P	LemA family
Thimo_3310	ENOG41074FZ	May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity)
Thimo_3311	ENOG4105E4F	Isochorismate synthase
Thimo_3312	ENOG4105C4A	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity)
Thimo_3313	ENOG4108IPT	Naphthoate synthase
Thimo_3315	ENOG4105DTQ	mandelate racemase muconate lactonizing
Thimo_3317	ENOG4107SBB	4-alpha-glucanotransferase (EC 2.4.1.25)
Thimo_3318	ENOG4107QQ4	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity)
Thimo_3319	ENOG4105C9C	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity)
Thimo_3320	ENOG4105VEQ	Cold shock protein
Thimo_3321	ENOG4107QX8	SPFH domain, Band 7 family protein
Thimo_3323	ENOG4108ZAF	Molybdopterin
Thimo_3326	ENOG4108HRN	Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity)
Thimo_3328	ENOG4105CA4	amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity)
Thimo_3329	ENOG4108W63	CRP FNR family transcriptional regulator
Thimo_3332	ENOG4105DH5	Responsible for the end-turnover of tRNA specifically removes the terminal AMP residue from uncharged tRNA (tRNA-C-C-A). Also appears to be involved in tRNA biosynthesis (By similarity)
Thimo_3334	ENOG4105CAQ	asparagine synthetase
Thimo_3337	ENOG4105CK4	Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity)
Thimo_3342	ENOG4108SX7	hmc operon protein 5
Thimo_3343	ENOG4105E3S	small subunit
Thimo_3357	ENOG4105CQV	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
Thimo_3359	ENOG4105C47	NADH ubiquinone oxidoreductase 20 kda subunit
Thimo_3361	ENOG4105D65	subunit l
Thimo_3362	ENOG4108UN4	phage SPO1 DNA polymerase-related protein
Thimo_3363	ENOG4105CYQ	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity)
Thimo_3368	ENOG4105EJ7	Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O (By similarity)
Thimo_3373	ENOG4107QQ4	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity)
Thimo_3374	ENOG4105CJI	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity)
Thimo_3375	ENOG4105C0V	Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity)
Thimo_3377	ENOG4109015	Biopolymer transport protein exbD tolR
Thimo_3378	ENOG4105BZ1	(ABC) transporter
Thimo_3379	ENOG4105CHD	Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) (By similarity)
Thimo_3380	ENOG4105W49	UPF0434 protein
Thimo_3381	ENOG4105CET	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria (By similarity)
Thimo_3383	ENOG4105EEQ	Na H antiporter
Thimo_3393	ENOG4105C59	p-type ATPase
Thimo_3397	ENOG4105CJ3	phosphate transporter
Thimo_3398	ENOG4105D4J	Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate
Thimo_3402	ENOG4105BZU	Histidine kinase
Thimo_3403	ENOG4105BZU	Histidine kinase
Thimo_3405	ENOG4105EFT	decarboxylase
Thimo_3420	ENOG4105D0M	Protease HtpX homolog
Thimo_3426	ENOG4105EB3	Histidine kinase
Thimo_3427	ENOG4105E3W	Two component transcriptional regulator (Winged helix family
Thimo_3436	ENOG4108JPX	Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity)
Thimo_3437	ENOG4105CXW	Synthesizes alpha-1,4-glucan chains using ADP-glucose (By similarity)
Thimo_3438	ENOG4108IUK	alpha amylase, catalytic
Thimo_3440	ENOG4105CU5	Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity)
Thimo_3442	ENOG4105CGK	Exodeoxyribonuclease III
Thimo_3443	ENOG4105CIW	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity)
Thimo_3445	ENOG4105DUF	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity)
Thimo_3454	ENOG41080ET	plasmid maintenance system killer protein
Thimo_3459	ENOG4105YES	addiction module antidote protein
Thimo_3463	ENOG4108Z6B	deaminase
Thimo_3465	ENOG4105CJD	(Anaerobic) ribonucleoside-triphosphate reductase
Thimo_3477	ENOG4105C8Q	Methyl-accepting chemotaxis
Thimo_3481	ENOG4105BZS	acriflavin resistance protein
Thimo_3483	ENOG410689M	(LipO)protein
Thimo_3492	ENOG4105DTJ	flagellar hook-associated protein
Thimo_3493	ENOG4105E1Q	flagellar hook-associated protein
Thimo_3494	ENOG4108ZW7	flagellar rod assembly protein muramidase flgj
Thimo_3495	ENOG4105D92	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation (By similarity)
Thimo_3496	ENOG4107W7W	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation (By similarity)
Thimo_3497	ENOG4105CGA	flagellar basal-body rod protein FlgG
Thimo_3498	ENOG4108KPB	Flagellar basal-body rod protein FlgF
Thimo_3499	ENOG4105BZE	flagellar hook protein, FlgE
Thimo_3500	ENOG4105W00	Flagellar hook capping protein
Thimo_3501	ENOG4108ZC9	flagellar basal-body rod protein flgc
Thimo_3505	ENOG4108Z86	Glutamine amidotransferase
Thimo_3510	ENOG4105DJ0	Poly(A) Polymerase
Thimo_3511	ENOG4105K8U	2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
Thimo_3512	ENOG4105CCG	Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity)
Thimo_3513	ENOG4108IAA	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity)
Thimo_3514	ENOG4108Z2X	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine (By similarity)
Thimo_3515	ENOG4105CXW	Synthesizes alpha-1,4-glucan chains using ADP-glucose (By similarity)
Thimo_3516	ENOG4105D8W	glucose-6-phosphate 1-dehydrogenase
Thimo_3517	ENOG4107QP8	phosphohexose isomerase
Thimo_3518	ENOG4105CYN	Serine protein kinase
Thimo_3519	ENOG4106AKX	UPF0229 protein
Thimo_3520	ENOG4105ED1	spovr family
Thimo_3521	ENOG4105DIT	ErfK YbiS YcfS YnhG family protein
Thimo_3522	ENOG4105D9I	Responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6 (By similarity)
Thimo_3524	ENOG4105EHM	Aminoglycoside phosphotransferase
Thimo_3545	ENOG4105C1X	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity (By similarity)
Thimo_3556	ENOG41081F0	Precorrin-8x methylmutase
Thimo_3557	ENOG4105GR3	Histidine kinase
Thimo_3562	ENOG4105EQW	The exact function is not known. Can catalyze the reduction of a variety of substrates like dimethyl sulfoxide, trimethylamine N-oxide, phenylmethyl sulfoxide and L-methionine sulfoxide. Cannot reduce cyclic N-oxides. Shows no activity as sulfite oxidase (By similarity)
Thimo_3563	ENOG4108S1C	Thiosulfate reductase cytochrome B subunit (Membrane anchoring protein)
Thimo_3573	ENOG4105BZ1	(ABC) transporter
Thimo_3589	ENOG4105CAQ	asparagine synthetase
Thimo_3597	ENOG4108RW0	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity)
Thimo_3598	ENOG4105CP4	Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity)
Thimo_3599	ENOG4105CM0	Catalyzes the synthesis of GMP from XMP (By similarity)
Thimo_3602	ENOG4107QQG	Dehydrogenase
Thimo_3603	ENOG4107S5T	Carbohydrate kinase
Thimo_3604	ENOG4107YRI	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) (By similarity)
Thimo_3605	ENOG41067SF	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase (By similarity)
Thimo_3606	ENOG4105DHA	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity (By similarity)
Thimo_3607	ENOG4105CMW	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity)
Thimo_3608	ENOG4105C5T	Phosphoribosyl pyrophosphate synthase
Thimo_3609	ENOG4105CDY	transcriptional regulatory protein
Thimo_3610	ENOG4105NHU	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group (By similarity)
Thimo_3611	ENOG4105KA4	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity)
Thimo_3612	ENOG4105E6M	Sulphatase-modifying factor protein
Thimo_3613	ENOG4108WIW	Aspartyl protease
Thimo_3614	ENOG4105C7K	acetolactate synthase
Thimo_3616	ENOG4105VN1	Heat shock protein
Thimo_3617	ENOG4105VN1	Heat shock protein
Thimo_3618	ENOG4105CFZ	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity)
Thimo_3619	ENOG4105DEK	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity)
Thimo_3620	ENOG4105CRP	Part of the ABC transporter FtsEX involved in
Thimo_3621	ENOG4105CAK	Cell division ATP-binding protein ftsE
Thimo_3622	ENOG4105CCP	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC)
Thimo_3625	ENOG4106H78	methyltransferase
Thimo_3626	ENOG4108ZEF	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity)
Thimo_3627	ENOG4105K5D	4fe-4S ferredoxin iroN-sulfur binding
Thimo_3628	ENOG4105DQF	Hydrolase
Thimo_3629	ENOG4105ERD	Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity)
Thimo_3631	ENOG4107EEM	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity)
Thimo_3635	ENOG4105DDZ	Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity)
Thimo_3639	ENOG4105EAC	phosphoserine phosphatase
Thimo_3642	ENOG4108Z67	carbohydrate kinase, thermoresistant glucokinase family
Thimo_3643	ENOG4105WCA	Ferredoxin
Thimo_3644	ENOG4108VQE	nitrogen fixation protein
Thimo_3645	ENOG4108UR2	Nitrogen fixation protein NifX
Thimo_3646	ENOG4105DK8	Nitrogenase molybdenum-iron cofactor biosynthesis protein NifN
Thimo_3647	ENOG4105D0B	Nitrogenase protein alpha chain
Thimo_3650	ENOG4105CRQ	synthase (Component I)
Thimo_3651	ENOG4108VXP	Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity)
Thimo_3652	ENOG4105DJV	ribulose-phosphate 3-epimerase
Thimo_3653	ENOG4105CPC	Aldo Keto reductase
Thimo_3654	ENOG4105MJ2	Competence protein
Thimo_3657	ENOG4108IJ7	Glycine betaine
Thimo_3661	ENOG4105C94	Transporter
Thimo_3665	ENOG4105CI6	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving
Thimo_3666	ENOG4105C5V	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity)
Thimo_3667	ENOG4105M6F	mutator MutT protein
Thimo_3668	ENOG4107S0N	DJ-1 family
Thimo_3669	ENOG4105CN1	protease
Thimo_3670	ENOG41063SB	peptidase
Thimo_3671	ENOG41080HT	Transcriptional regulator, arsr family
Thimo_3672	ENOG4107YZP	Rhodanese domain protein
Thimo_3673	ENOG4105IX2	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA (By similarity)
Thimo_3674	ENOG4105CSF	NADPH-dependent glycerol-3-phosphate dehydrogenase
Thimo_3675	ENOG4108UIQ	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity)
Thimo_3676	ENOG4107QYT	Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor (By similarity)
Thimo_3679	ENOG4105C1W	two component, sigma54 specific, transcriptional regulator, Fis family
Thimo_3680	ENOG4105CUX	Signal transduction histidine kinase
Thimo_3682	ENOG4105C5F	glutamine synthetase
Thimo_3684	ENOG4108HMW	glycyl-tRNA synthetase, alpha subunit
Thimo_3685	ENOG4105C38	Glycyl-tRNA synthetase beta subunit
Thimo_3686	ENOG4108ZI0	d,d-heptose 1,7-bisphosphate phosphatase
Thimo_3697	ENOG4105DAX	Pfam:DUF2983
Thimo_3699	ENOG4108S0S	Nucleotidyl transferase
Thimo_3701	ENOG4105C1H	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity)
Thimo_3702	ENOG4105DHW	Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins
Thimo_3710	ENOG4105CK3	Lysine 2,3-aminomutase YodO family protein
Thimo_3714	ENOG4108JPW	Aminotransferase
Thimo_3728	ENOG4105YAJ	CopG Arc MetJ
Thimo_3733	ENOG4105W5Q	DNA repair protein (RadC
Thimo_3738	ENOG4105FA0	parb-like partition protein
Thimo_3743	ENOG4105W5Q	DNA repair protein (RadC
Thimo_3749	ENOG4108ZX5	transcriptional regulator
Thimo_3759	ENOG4108PCE	TRANSFER protein
Thimo_3760	ENOG4105CMA	conjugation trbi family protein
Thimo_3761	ENOG4108EHY	type IV secretion system
Thimo_3767	ENOG4107SKI	cobyrinic Acid a,c-diamide synthase
Thimo_3774	ENOG4105EKQ	RNA-directed DNA polymerase