locus-tag	class	description
TspCOW1_00010	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
TspCOW1_00030	COG1763	Mo-molybdopterin cofactor biosynthetic process
TspCOW1_00040	COG0746	molybdenum cofactor guanylyltransferase activity
TspCOW1_00080	COG0318	PFAM AMP-dependent synthetase and ligase
TspCOW1_00100	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
TspCOW1_00110	COG3118	belongs to the thioredoxin family
TspCOW1_00120	COG1074	ATP-dependent DNA helicase activity
TspCOW1_00150	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
TspCOW1_00160	COG5001	Diguanylate cyclase
TspCOW1_00160	COG4251	negative regulation of phosphorylation
TspCOW1_00160	COG3706	GGDEF domain
TspCOW1_00160	COG2203	Gaf domain
TspCOW1_00230	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
TspCOW1_00280	COG1484	DNA-dependent DNA replication
TspCOW1_00290	COG4584	PFAM Integrase catalytic
TspCOW1_00310	COG1309	transcriptional regulator
TspCOW1_00330	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
TspCOW1_00340	COG1752	Esterase of the alpha-beta hydrolase superfamily
TspCOW1_00390	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
TspCOW1_00400	COG1129	ABC transporter
TspCOW1_00400	COG0842	Transport permease protein
TspCOW1_00410	COG1129	ABC transporter
TspCOW1_00410	COG0842	Transport permease protein
TspCOW1_00420	COG0842	Transport permease protein
TspCOW1_00450	COG2814	Major facilitator Superfamily
TspCOW1_00460	COG1566	PFAM secretion protein HlyD family protein
TspCOW1_00490	COG1902	pentaerythritol trinitrate reductase activity
TspCOW1_00500	COG0625	glutathione transferase activity
TspCOW1_00510	COG1733	regulation of RNA biosynthetic process
TspCOW1_00620	COG0270	DNA (cytosine-5-)-methyltransferase activity
TspCOW1_00700	COG2856	Zn peptidase
TspCOW1_00920	COG4771	TonB-dependent receptor
TspCOW1_00950	COG0348	domain, Protein
TspCOW1_00960	COG1775	2-hydroxyglutaryl-CoA dehydratase, D-component
TspCOW1_01000	COG3039	Transposase
TspCOW1_01060	COG2003	Belongs to the UPF0758 family
TspCOW1_01150	COG1475	DNA binding
TspCOW1_01160	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
TspCOW1_01240	COG2894	cell division
TspCOW1_01390	COG1546	Belongs to the CinA family
TspCOW1_01410	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
TspCOW1_01420	COG2137	regulation of response to DNA damage stimulus
TspCOW1_01430	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
TspCOW1_01440	COG0527	aspartate kinase activity
TspCOW1_01450	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
TspCOW1_01500	COG2831	hemolysin activation secretion protein
TspCOW1_01540	COG0811	peptide transport
TspCOW1_01550	COG0848	biopolymer transport protein
TspCOW1_01900	COG1061	Type III restriction enzyme res subunit
TspCOW1_01970	COG1475	DNA binding
TspCOW1_02310	COG3727	T/G mismatch-specific endonuclease activity
TspCOW1_02360	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
TspCOW1_02380	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
TspCOW1_02430	COG3177	Filamentation induced by cAMP protein fic
TspCOW1_02450	COG2963	transposase activity
TspCOW1_02460	COG2801	Transposase and inactivated derivatives
TspCOW1_02480	COG1024	Enoyl-CoA hydratase
TspCOW1_02490	COG2198	Histidine kinase
TspCOW1_02490	COG0784	Response regulator, receiver
TspCOW1_02490	COG2205	protein histidine kinase activity
TspCOW1_02510	COG2081	HI0933 family
TspCOW1_02550	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
TspCOW1_02560	COG3002	Belongs to the UPF0753 family
TspCOW1_02610	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
TspCOW1_02640	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
TspCOW1_02680	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
TspCOW1_02690	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
TspCOW1_02700	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
TspCOW1_02730	COG0537	adenosine 5'-monophosphoramidase activity
TspCOW1_02740	COG1162	GTPase activity
TspCOW1_02750	COG2154	pterin-4-alpha-carbinolamine dehydratase
TspCOW1_02770	COG0501	Belongs to the peptidase M48B family
TspCOW1_02780	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
TspCOW1_02800	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
TspCOW1_02820	COG0033	Phosphoglucomutase
TspCOW1_02840	COG1959	2 iron, 2 sulfur cluster binding
TspCOW1_02860	COG1454	alcohol dehydrogenase
TspCOW1_02890	COG5001	Diguanylate cyclase
TspCOW1_02890	COG3300	MHYT domain
TspCOW1_02910	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
TspCOW1_02930	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
TspCOW1_03000	COG0058	SHG alpha-glucan phosphorylase activity
TspCOW1_03010	COG0537	adenosine 5'-monophosphoramidase activity
TspCOW1_03040	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
TspCOW1_03080	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
TspCOW1_03080	COG3608	succinylglutamate desuccinylase aspartoacylase
TspCOW1_03090	COG0746	molybdenum cofactor guanylyltransferase activity
TspCOW1_03110	COG1388	LysM domain
TspCOW1_03110	COG0741	lytic transglycosylase activity
TspCOW1_03130	COG0328	RNA-DNA hybrid ribonuclease activity
TspCOW1_03150	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
TspCOW1_03180	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
TspCOW1_03200	COG2205	protein histidine kinase activity
TspCOW1_03210	COG2204	response regulator
TspCOW1_03260	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
TspCOW1_03300	COG0489	protein tyrosine kinase activity
TspCOW1_03320	COG3267	Type II secretory pathway component ExeA
TspCOW1_03320	COG3409	Peptidoglycan-binding domain 1 protein
TspCOW1_03380	COG0438	transferase activity, transferring glycosyl groups
TspCOW1_03390	COG0367	asparagine synthase
TspCOW1_03400	COG0438	transferase activity, transferring glycosyl groups
TspCOW1_03410	COG0438	transferase activity, transferring glycosyl groups
TspCOW1_03480	COG0438	transferase activity, transferring glycosyl groups
TspCOW1_03500	COG2166	iron-sulfur cluster assembly
TspCOW1_03510	COG0316	Belongs to the HesB IscA family
TspCOW1_03520	COG2151	metal-sulfur cluster biosynthetic enzyme
TspCOW1_03530	COG0719	Fe-S assembly protein
TspCOW1_03540	COG0396	ATPase activity
TspCOW1_03550	COG0719	Fe-S assembly protein
TspCOW1_03570	COG3119	arylsulfatase activity
TspCOW1_03580	COG0457	Tetratricopeptide repeat
TspCOW1_03610	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
TspCOW1_03640	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
TspCOW1_03690	COG0409	Hydrogenase expression formation protein
TspCOW1_03710	COG0375	protein maturation
TspCOW1_03720	COG0298	carbon dioxide binding
TspCOW1_03790	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
TspCOW1_03820	COG0543	2 iron, 2 sulfur cluster binding
TspCOW1_03850	COG1752	Esterase of the alpha-beta hydrolase superfamily
TspCOW1_03880	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
TspCOW1_03900	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
TspCOW1_03920	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
TspCOW1_04000	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
TspCOW1_04030	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
TspCOW1_04050	COG0191	fructose-bisphosphate aldolase activity
TspCOW1_04060	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
TspCOW1_04060	COG1796	DNA polymerase
TspCOW1_04090	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
TspCOW1_04100	COG1067	ATP-dependent peptidase activity
TspCOW1_04150	COG4737	Cytotoxic translational repressor of toxin-antitoxin stability system
TspCOW1_04160	COG2944	sequence-specific DNA binding
TspCOW1_04220	COG0589	response to stress
TspCOW1_04250	COG0561	phosphatase activity
TspCOW1_04250	COG3100	YcgL domain-containing protein
TspCOW1_04260	COG0084	hydrolase, TatD family'
TspCOW1_04300	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
TspCOW1_04320	COG2350	Protein conserved in bacteria
TspCOW1_04330	COG2917	probably involved in intracellular septation
TspCOW1_04340	COG0613	PHP domain protein
TspCOW1_04350	COG0009	L-threonylcarbamoyladenylate synthase
TspCOW1_04360	COG1994	Peptidase M50
TspCOW1_04370	COG0180	Tryptophanyl-tRNA synthetase
TspCOW1_04390	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
TspCOW1_04400	COG1187	pseudouridine synthase activity
TspCOW1_04420	COG3706	GGDEF domain
TspCOW1_04440	COG1028	Short-chain dehydrogenase reductase Sdr
TspCOW1_04450	COG1233	COG1233 Phytoene dehydrogenase and related
TspCOW1_04460	COG1562	ergosterol biosynthetic process
TspCOW1_04480	COG1322	Protein conserved in bacteria
TspCOW1_04510	COG0402	S-adenosylhomocysteine deaminase activity
TspCOW1_04520	COG0668	transmembrane transport
TspCOW1_04530	COG3047	cAMP biosynthetic process
TspCOW1_04530	COG2885	chlorophyll binding
TspCOW1_04550	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
TspCOW1_04570	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
TspCOW1_04580	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
TspCOW1_04590	COG0077	Prephenate dehydratase
TspCOW1_04590	COG1605	Chorismate mutase
TspCOW1_04600	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
TspCOW1_04610	COG0287	Prephenate dehydrogenase
TspCOW1_04620	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
TspCOW1_04630	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
TspCOW1_04650	COG0776	regulation of translation
TspCOW1_04670	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
TspCOW1_04680	COG0284	orotidine-5'-phosphate decarboxylase activity
TspCOW1_04690	COG1555	photosystem II stabilization
TspCOW1_04700	COG0662	Cupin 2, conserved barrel domain protein
TspCOW1_04700	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
TspCOW1_04760	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
TspCOW1_04770	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
TspCOW1_04780	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
TspCOW1_04790	COG2226	methyltransferase
TspCOW1_04840	COG0463	Glycosyl transferase, family 2
TspCOW1_04880	COG0436	Aminotransferase
TspCOW1_04910	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
TspCOW1_04920	COG1858	cytochrome C peroxidase
TspCOW1_04930	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
TspCOW1_04940	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
TspCOW1_04950	COG0291	Belongs to the bacterial ribosomal protein bL35 family
TspCOW1_04960	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
TspCOW1_04970	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
TspCOW1_04990	COG0776	regulation of translation
TspCOW1_05010	COG2801	Transposase and inactivated derivatives
TspCOW1_05030	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
TspCOW1_05040	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
TspCOW1_05050	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
TspCOW1_05090	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
TspCOW1_05100	COG1053	succinate dehydrogenase
TspCOW1_05110	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
TspCOW1_05130	COG2954	triphosphatase activity
TspCOW1_05160	COG0601	transmembrane transport
TspCOW1_05170	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
TspCOW1_05180	COG1472	Belongs to the glycosyl hydrolase 3 family
TspCOW1_05190	COG0668	transmembrane transport
TspCOW1_05200	COG1752	Esterase of the alpha-beta hydrolase superfamily
TspCOW1_05210	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
TspCOW1_05220	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
TspCOW1_05230	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
TspCOW1_05240	COG3153	acetyltransferase
TspCOW1_05240	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
TspCOW1_05290	COG2801	Transposase and inactivated derivatives
TspCOW1_05350	COG3344	reverse transcriptase
TspCOW1_05370	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
TspCOW1_05380	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
TspCOW1_05390	COG4106	trans-aconitate 2-methyltransferase activity
TspCOW1_05400	COG2983	Belongs to the UPF0260 family
TspCOW1_05470	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
TspCOW1_05480	COG1393	Belongs to the ArsC family
TspCOW1_05500	COG0640	Transcriptional regulator
TspCOW1_05510	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
TspCOW1_05520	COG0798	PFAM Bile acid sodium symporter
TspCOW1_05550	COG2133	pyrroloquinoline quinone binding
TspCOW1_05560	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
TspCOW1_05600	COG1320	monovalent cation:proton antiporter activity
TspCOW1_05610	COG2212	antiporter activity
TspCOW1_05630	COG0651	ATP synthesis coupled electron transport
TspCOW1_05640	COG1006	Multisubunit Na H antiporter MnhC subunit
TspCOW1_05650	COG2111	Na H antiporter
TspCOW1_05650	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
TspCOW1_05660	COG2171	N-acyltransferase activity
TspCOW1_05720	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
TspCOW1_05730	COG0024	Methionine aminopeptidase
TspCOW1_05740	COG0052	Belongs to the universal ribosomal protein uS2 family
TspCOW1_05750	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
TspCOW1_05760	COG0528	UMP kinase activity
TspCOW1_05770	COG0233	cytoplasmic translational termination
TspCOW1_05780	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
TspCOW1_05790	COG0575	Belongs to the CDS family
TspCOW1_05800	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
TspCOW1_05840	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
TspCOW1_05850	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
TspCOW1_05860	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
TspCOW1_05870	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
TspCOW1_05900	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
TspCOW1_05910	COG1136	(ABC) transporter
TspCOW1_05910	COG0577	efflux transmembrane transporter activity
TspCOW1_05920	COG0577	efflux transmembrane transporter activity
TspCOW1_05920	COG1136	(ABC) transporter
TspCOW1_05940	COG0825	malonyl-CoA metabolic process
TspCOW1_05950	COG0037	tRNA processing
TspCOW1_05960	COG0504	CTP synthase activity
TspCOW1_05970	COG2877	3-deoxy-8-phosphooctulonate synthase activity
TspCOW1_05980	COG0148	phosphopyruvate hydratase activity
TspCOW1_05990	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
TspCOW1_06000	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
TspCOW1_06010	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
TspCOW1_06020	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
TspCOW1_06040	COG1943	Transposase
TspCOW1_06110	COG0585	pseudouridine synthase activity
TspCOW1_06120	COG1193	negative regulation of DNA recombination
TspCOW1_06130	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
TspCOW1_06140	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
TspCOW1_06150	COG1238	metal cluster binding
TspCOW1_06190	COG0436	Aminotransferase
TspCOW1_06210	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
TspCOW1_06230	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
TspCOW1_06250	COG3108	Peptidase M15
TspCOW1_06270	COG3263	regulation of cellular component size
TspCOW1_06320	COG1156	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit
TspCOW1_06330	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
TspCOW1_06370	COG1269	ATP hydrolysis coupled proton transport
TspCOW1_06410	COG0589	response to stress
TspCOW1_06440	COG2239	Acts as a magnesium transporter
TspCOW1_06510	COG1969	Ni Fe-hydrogenase, b-type cytochrome subunit
TspCOW1_06590	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
TspCOW1_06610	COG2915	High frequency lysogenization protein hflD homolog
TspCOW1_06660	COG1278	Cold shock
TspCOW1_06670	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
TspCOW1_06680	COG0542	response to heat
TspCOW1_06690	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
TspCOW1_06700	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
TspCOW1_06710	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
TspCOW1_06730	COG0492	ferredoxin-NADP+ reductase activity
TspCOW1_06740	COG0686	Belongs to the AlaDH PNT family
TspCOW1_06750	COG1674	ftsk spoiiie
TspCOW1_06760	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
TspCOW1_06780	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
TspCOW1_06790	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
TspCOW1_06810	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
TspCOW1_06830	COG3706	GGDEF domain
TspCOW1_06870	COG0308	aminopeptidase N
TspCOW1_06890	COG1648	precorrin-2 dehydrogenase activity
TspCOW1_06890	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
TspCOW1_06920	COG1252	NADH dehydrogenase
TspCOW1_06950	COG2197	response regulator
TspCOW1_06960	COG3850	Histidine kinase
TspCOW1_06980	COG1797	cobyrinic acid a,c-diamide synthase activity
TspCOW1_07050	COG2920	part of a sulfur-relay system
TspCOW1_07070	COG2923	Belongs to the DsrF TusC family
TspCOW1_07080	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
TspCOW1_07090	COG2221	Nitrite and sulphite reductase 4Fe-4S
TspCOW1_07100	COG2221	Nitrite and sulphite reductase 4Fe-4S
TspCOW1_07160	COG3128	pkhd-type hydroxylase
TspCOW1_07190	COG3706	GGDEF domain
TspCOW1_07200	COG0730	response to heat
TspCOW1_07210	COG0456	acetyltransferase
TspCOW1_07260	COG1404	Belongs to the peptidase S8 family
TspCOW1_07330	COG0670	Belongs to the BI1 family
TspCOW1_07360	COG0740	serine-type endopeptidase activity
TspCOW1_07470	COG2204	response regulator
TspCOW1_07550	COG1573	uracil-dna glycosylase
TspCOW1_07560	COG0322	excinuclease ABC activity
TspCOW1_07570	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
TspCOW1_07590	COG3588	fructose-bisphosphate aldolase
TspCOW1_07630	COG2020	methyltransferase activity
TspCOW1_07670	COG0668	transmembrane transport
TspCOW1_07700	COG0508	dehydrogenase complex catalyzes the overall conversion of
TspCOW1_07720	COG3174	membrane
TspCOW1_07740	COG2046	Belongs to the sulfate adenylyltransferase family
TspCOW1_07780	COG0189	ligase activity
TspCOW1_07790	COG4067	protein conserved in archaea
TspCOW1_07790	COG0189	ligase activity
TspCOW1_07810	COG3038	cytochrome b561
TspCOW1_07890	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
TspCOW1_07920	COG0642	Histidine kinase
TspCOW1_07980	COG1250	3-hydroxyacyl-CoA dehydrogenase
TspCOW1_07980	COG1024	Enoyl-CoA hydratase
TspCOW1_07990	COG1022	Amp-dependent synthetase and ligase
TspCOW1_08020	COG0084	hydrolase, TatD family'
TspCOW1_08050	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
TspCOW1_08060	COG1187	pseudouridine synthase activity
TspCOW1_08070	COG3245	cytochrome
TspCOW1_08090	COG0372	Belongs to the citrate synthase family
TspCOW1_08110	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
TspCOW1_08120	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
TspCOW1_08130	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
TspCOW1_08140	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
TspCOW1_08150	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
TspCOW1_08160	COG1028	Short-chain dehydrogenase reductase Sdr
TspCOW1_08170	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
TspCOW1_08180	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
TspCOW1_08190	COG0416	fatty acid biosynthetic process
TspCOW1_08200	COG0333	Belongs to the bacterial ribosomal protein bL32 family
TspCOW1_08220	COG0439	Biotin carboxylase
TspCOW1_08240	COG5016	pyruvate
TspCOW1_08240	COG0511	ligase activity, forming carbon-carbon bonds
TspCOW1_08250	COG0424	maF-like protein
TspCOW1_08280	COG0546	phosphoglycolate phosphatase activity
TspCOW1_08290	COG0564	pseudouridine synthase activity
TspCOW1_08300	COG1530	ribonuclease E activity
TspCOW1_08310	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
TspCOW1_08340	COG4251	negative regulation of phosphorylation
TspCOW1_08340	COG5001	Diguanylate cyclase
TspCOW1_08340	COG2203	Gaf domain
TspCOW1_08340	COG3706	GGDEF domain
TspCOW1_08400	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
TspCOW1_08410	COG2835	tetraacyldisaccharide 4'-kinase activity
TspCOW1_08420	COG1663	tetraacyldisaccharide 4'-kinase activity
TspCOW1_08430	COG1132	(ABC) transporter
TspCOW1_08440	COG0848	biopolymer transport protein
TspCOW1_08450	COG0811	peptide transport
TspCOW1_08460	COG2333	competence protein COMEC
TspCOW1_08460	COG0658	competence protein
TspCOW1_08480	COG1136	(ABC) transporter
TspCOW1_08490	COG4591	ABC-type transport system involved in lipoprotein release permease component
TspCOW1_08520	COG2957	Belongs to the agmatine deiminase family
TspCOW1_08530	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
TspCOW1_08540	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
TspCOW1_08540	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
TspCOW1_08550	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
TspCOW1_08590	COG0446	pyridine nucleotide-disulphide oxidoreductase
TspCOW1_08630	COG2210	Belongs to the sulfur carrier protein TusA family
TspCOW1_08680	COG1199	ATP-dependent helicase activity
TspCOW1_08710	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
TspCOW1_08740	COG0500	methyltransferase
TspCOW1_08750	COG0277	FAD linked oxidase domain protein
TspCOW1_08760	COG0277	FAD linked oxidase domain protein
TspCOW1_08770	COG0247	lactate metabolic process
TspCOW1_08790	COG0247	lactate metabolic process
TspCOW1_08870	COG0579	oxidoreductase
TspCOW1_08900	COG1376	ErfK ybiS ycfS ynhG family protein
TspCOW1_08930	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
TspCOW1_08940	COG3115	cell septum assembly
TspCOW1_08960	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
TspCOW1_08970	COG1070	Carbohydrate kinase
TspCOW1_08990	COG0436	Aminotransferase
TspCOW1_09020	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
TspCOW1_09040	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
TspCOW1_09080	COG1185	polyribonucleotide nucleotidyltransferase activity
TspCOW1_09090	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
TspCOW1_09100	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
TspCOW1_09110	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
TspCOW1_09120	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
TspCOW1_09130	COG2251	uridine kinase activity
TspCOW1_09130	COG0195	Participates in both transcription termination and antitermination
TspCOW1_09140	COG0779	Required for maturation of 30S ribosomal subunits
TspCOW1_09160	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
TspCOW1_09190	COG3273	potassium ion transport
TspCOW1_09190	COG0471	metal ion transport
TspCOW1_09220	COG4221	oxidoreductase activity
TspCOW1_09230	COG0789	Transcriptional regulator
TspCOW1_09260	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
TspCOW1_09300	COG2911	Protein conserved in bacteria
TspCOW1_09310	COG0729	surface antigen
TspCOW1_09320	COG0563	adenylate kinase activity
TspCOW1_09350	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
TspCOW1_09360	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
TspCOW1_09400	COG1007	ATP synthesis coupled electron transport
TspCOW1_09430	COG0713	ATP synthesis coupled electron transport
TspCOW1_09450	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
TspCOW1_09460	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
TspCOW1_09470	COG1034	ATP synthesis coupled electron transport
TspCOW1_09500	COG0649	NAD binding
TspCOW1_09510	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
TspCOW1_09520	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
TspCOW1_09530	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
TspCOW1_09550	COG0149	triose-phosphate isomerase activity
TspCOW1_09560	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
TspCOW1_09570	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
TspCOW1_09580	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
TspCOW1_09590	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
TspCOW1_09620	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
TspCOW1_09630	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
TspCOW1_09640	COG0505	Belongs to the CarA family
TspCOW1_09650	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
TspCOW1_09660	COG0484	heat shock protein binding
TspCOW1_09670	COG0443	Heat shock 70 kDa protein
TspCOW1_09680	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
TspCOW1_09690	COG1420	regulation of RNA biosynthetic process
TspCOW1_09700	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
TspCOW1_09710	COG0497	DNA recombination
TspCOW1_09720	COG0735	belongs to the Fur family
TspCOW1_09740	COG2914	Belongs to the UPF0125 (RnfH) family
TspCOW1_09760	COG0733	neurotransmitter:sodium symporter activity
TspCOW1_09770	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
TspCOW1_09790	COG1047	Peptidyl-prolyl cis-trans
TspCOW1_09840	COG2925	Exonuclease
TspCOW1_09870	COG2925	Exonuclease
TspCOW1_09880	COG3706	GGDEF domain
TspCOW1_09960	COG0450	alkyl hydroperoxide reductase
TspCOW1_10000	COG0306	phosphate transporter
TspCOW1_10030	COG2226	methyltransferase
TspCOW1_10070	COG0398	Pfam SNARE associated Golgi protein
TspCOW1_10090	COG0640	Transcriptional regulator
TspCOW1_10160	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
TspCOW1_10200	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
TspCOW1_10240	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
TspCOW1_10260	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
TspCOW1_10290	COG1216	Glycosyl transferase, family 2
TspCOW1_10350	COG0514	ATP-dependent DNA helicase (RecQ)
TspCOW1_10360	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
TspCOW1_10370	COG1262	PFAM Formylglycine-generating sulfatase enzyme
TspCOW1_10410	COG1278	Cold shock
TspCOW1_10460	COG0429	hydrolase of the alpha beta-hydrolase fold
TspCOW1_10480	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
TspCOW1_10490	COG1404	Belongs to the peptidase S8 family
TspCOW1_10500	COG4172	Belongs to the ABC transporter superfamily
TspCOW1_10510	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
TspCOW1_10520	COG0601	transmembrane transport
TspCOW1_10550	COG1301	dicarboxylic acid transport
TspCOW1_10560	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
TspCOW1_10580	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
TspCOW1_10590	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
TspCOW1_10600	COG0740	serine-type endopeptidase activity
TspCOW1_10610	COG0544	peptidyl-prolyl cis-trans isomerase activity
TspCOW1_10620	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
TspCOW1_10630	COG5002	protein histidine kinase activity
TspCOW1_10630	COG5001	Diguanylate cyclase
TspCOW1_10650	COG0215	cysteine-tRNA ligase activity
TspCOW1_10660	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
TspCOW1_10680	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
TspCOW1_10690	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
TspCOW1_10720	COG2833	Protein of unknown function (DUF455)
TspCOW1_10730	COG2379	hydroxypyruvate reductase
TspCOW1_10790	COG0285	dihydrofolate synthase activity
TspCOW1_10800	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
TspCOW1_10810	COG0159	tryptophan synthase activity
TspCOW1_10820	COG0133	tryptophan synthase activity
TspCOW1_10830	COG0135	phosphoribosylanthranilate isomerase activity
TspCOW1_10840	COG0101	tRNA pseudouridine synthase activity
TspCOW1_10900	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
TspCOW1_10910	COG0473	3-isopropylmalate dehydrogenase activity
TspCOW1_10930	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
TspCOW1_10960	COG5002	protein histidine kinase activity
TspCOW1_10960	COG5001	Diguanylate cyclase
TspCOW1_10970	COG1830	Aldolase
TspCOW1_11000	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
TspCOW1_11060	COG0688	phosphatidylethanolamine metabolic process
TspCOW1_11110	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
TspCOW1_11120	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
TspCOW1_11130	COG1862	Preprotein translocase
TspCOW1_11140	COG0343	queuine tRNA-ribosyltransferase activity
TspCOW1_11150	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
TspCOW1_11170	COG1640	4-alpha-glucanotransferase
TspCOW1_11190	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
TspCOW1_11200	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
TspCOW1_11240	COG1355	regulation of microtubule-based process
TspCOW1_11250	COG3885	ferrous iron binding
TspCOW1_11250	COG2078	PFAM AMMECR1 domain protein
TspCOW1_11310	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
TspCOW1_11350	COG0835	chemotaxis
TspCOW1_11380	COG1192	Involved in chromosome partitioning
TspCOW1_11390	COG2201	protein-glutamate methylesterase activity
TspCOW1_11400	COG0643	Histidine kinase
TspCOW1_11400	COG2198	Histidine kinase
TspCOW1_11400	COG0784	Response regulator, receiver
TspCOW1_11410	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
TspCOW1_11460	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
TspCOW1_11490	COG1987	bacterial-type flagellum assembly
TspCOW1_11550	COG3122	Protein conserved in bacteria
TspCOW1_11570	COG0513	Belongs to the DEAD box helicase family
TspCOW1_11580	COG3344	reverse transcriptase
TspCOW1_11600	COG2801	Transposase and inactivated derivatives
TspCOW1_11680	COG3300	MHYT domain
TspCOW1_11680	COG5001	Diguanylate cyclase
TspCOW1_11720	COG1317	bacterial-type flagellum organization
TspCOW1_11750	COG1677	Flagellar hook-basal body complex protein FliE
TspCOW1_11820	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
TspCOW1_11860	COG5002	protein histidine kinase activity
TspCOW1_11860	COG5001	Diguanylate cyclase
TspCOW1_11890	COG3951	Flagellar rod assembly protein muramidase FlgJ
TspCOW1_11890	COG1705	Flagellar rod assembly protein muramidase FlgJ
TspCOW1_11900	COG1706	bacterial-type flagellum-dependent cell motility
TspCOW1_11910	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
TspCOW1_11950	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
TspCOW1_11980	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
TspCOW1_11990	COG0784	Response regulator, receiver
TspCOW1_11990	COG0835	chemotaxis
TspCOW1_12000	COG1261	Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P-ring assembly
TspCOW1_12080	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
TspCOW1_12120	COG1127	ABC transporter
TspCOW1_12130	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
TspCOW1_12140	COG1366	Belongs to the anti-sigma-factor antagonist family
TspCOW1_12180	COG1408	metallophosphoesterase
TspCOW1_12220	COG2205	protein histidine kinase activity
TspCOW1_12220	COG0784	Response regulator, receiver
TspCOW1_12220	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
TspCOW1_12220	COG2198	Histidine kinase
TspCOW1_12270	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
TspCOW1_12290	COG0415	Belongs to the DNA photolyase family
TspCOW1_12320	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
TspCOW1_12360	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
TspCOW1_12380	COG1131	(ABC) transporter
TspCOW1_12420	COG2308	Evidence 4 Homologs of previously reported genes of
TspCOW1_12870	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
TspCOW1_12890	COG1111	helicase
TspCOW1_12890	COG1205	dead DEAH box helicase
TspCOW1_12960	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
TspCOW1_13120	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
TspCOW1_13130	COG2221	Nitrite and sulphite reductase 4Fe-4S
TspCOW1_13140	COG2221	Nitrite and sulphite reductase 4Fe-4S
TspCOW1_13150	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
TspCOW1_13150	COG0517	IMP dehydrogenase activity
TspCOW1_13150	COG0617	tRNA 3'-terminal CCA addition
TspCOW1_13170	COG2863	cytochrome
TspCOW1_13180	COG3258	Cytochrome c
TspCOW1_13190	COG2226	methyltransferase
TspCOW1_13260	COG0811	peptide transport
TspCOW1_13340	COG1597	lipid kinase activity
TspCOW1_13410	COG0456	acetyltransferase
TspCOW1_13420	COG1560	Kdo2-lipid A biosynthetic process
TspCOW1_13460	COG1132	(ABC) transporter
TspCOW1_13500	COG0156	8-amino-7-oxononanoate synthase activity
TspCOW1_13510	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
TspCOW1_13560	COG0583	DNA-binding transcription factor activity
TspCOW1_13570	COG2920	part of a sulfur-relay system
TspCOW1_13580	COG0516	GMP reductase activity
TspCOW1_13580	COG0517	IMP dehydrogenase activity
TspCOW1_13590	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
TspCOW1_13630	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
TspCOW1_13650	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
TspCOW1_13700	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
TspCOW1_13810	COG2814	Major facilitator Superfamily
TspCOW1_13820	COG0842	Transport permease protein
TspCOW1_13830	COG0842	Transport permease protein
TspCOW1_13830	COG1129	ABC transporter
TspCOW1_13840	COG0842	Transport permease protein
TspCOW1_13840	COG1129	ABC transporter
TspCOW1_13850	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
TspCOW1_13900	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
TspCOW1_14010	COG0640	Transcriptional regulator
TspCOW1_14130	COG3549	Plasmid maintenance system killer
TspCOW1_14140	COG0519	Catalyzes the synthesis of GMP from XMP
TspCOW1_14140	COG0518	GMP synthase (glutamine-hydrolyzing) activity
TspCOW1_14160	COG1570	exodeoxyribonuclease VII activity
TspCOW1_14190	COG0167	dihydroorotate dehydrogenase activity
TspCOW1_14200	COG0674	pyruvate-flavodoxin oxidoreductase activity
TspCOW1_14200	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
TspCOW1_14200	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
TspCOW1_14200	COG1013	pyruvate-flavodoxin oxidoreductase activity
TspCOW1_14220	COG4181	ATPase activity
TspCOW1_14240	COG0659	secondary active sulfate transmembrane transporter activity
TspCOW1_14250	COG1160	GTP binding
TspCOW1_14280	COG0124	histidyl-tRNA synthetase
TspCOW1_14310	COG0820	rRNA (adenine-C2-)-methyltransferase activity
TspCOW1_14320	COG0105	UTP biosynthetic process
TspCOW1_14340	COG1959	2 iron, 2 sulfur cluster binding
TspCOW1_14390	COG1127	ABC transporter
TspCOW1_14400	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
TspCOW1_14410	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
TspCOW1_14420	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
TspCOW1_14430	COG1509	lysine 2,3-aminomutase activity
TspCOW1_14460	COG5001	Diguanylate cyclase
TspCOW1_14460	COG5002	protein histidine kinase activity
TspCOW1_14480	COG0501	Belongs to the peptidase M48B family
TspCOW1_14600	COG1592	Rubrerythrin
TspCOW1_14610	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
TspCOW1_14670	COG1722	exodeoxyribonuclease VII activity
TspCOW1_14680	COG0142	geranyltranstransferase activity
TspCOW1_14690	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
TspCOW1_14700	COG0720	synthase
TspCOW1_14710	COG1469	GTP cyclohydrolase I activity
TspCOW1_14730	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
TspCOW1_14760	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
TspCOW1_14790	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
TspCOW1_14790	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
TspCOW1_14800	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
TspCOW1_14810	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
TspCOW1_14830	COG0488	(ABC) transporter
TspCOW1_14860	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
TspCOW1_14880	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
TspCOW1_14900	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
TspCOW1_14910	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
TspCOW1_14920	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
TspCOW1_14940	COG2716	regulation of RNA biosynthetic process
TspCOW1_14950	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
TspCOW1_14960	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
TspCOW1_14990	COG0583	DNA-binding transcription factor activity
TspCOW1_15020	COG0840	transmembrane signaling receptor activity
TspCOW1_15060	COG2067	long-chain fatty acid transport protein
TspCOW1_15070	COG0425	Belongs to the sulfur carrier protein TusA family
TspCOW1_15080	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
TspCOW1_15090	COG4783	chaperone-mediated protein folding
TspCOW1_15130	COG3258	Cytochrome c
TspCOW1_15140	COG0737	Belongs to the 5'-nucleotidase family
TspCOW1_15150	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
TspCOW1_15170	COG4771	TonB-dependent receptor
TspCOW1_15210	COG4772	TonB-dependent receptor
TspCOW1_15240	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
TspCOW1_15250	COG0583	DNA-binding transcription factor activity
TspCOW1_15270	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
TspCOW1_15300	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
TspCOW1_15310	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
TspCOW1_15320	COG4558	Periplasmic binding protein
TspCOW1_15330	COG0748	coenzyme F420 binding
TspCOW1_15350	COG4771	TonB-dependent receptor
TspCOW1_15410	COG0783	Belongs to the Dps family
TspCOW1_15420	COG0588	phosphoglycerate mutase activity
TspCOW1_15520	COG1294	oxidase, subunit
TspCOW1_15570	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
TspCOW1_15600	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
TspCOW1_15610	COG0602	queuosine metabolic process
TspCOW1_15620	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
TspCOW1_15640	COG0823	Involved in the tonB-independent uptake of proteins
TspCOW1_15680	COG0824	Thioesterase
TspCOW1_15690	COG2255	four-way junction helicase activity
TspCOW1_15700	COG0632	four-way junction helicase activity
TspCOW1_15710	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
TspCOW1_15720	COG0217	transcriptional regulatory protein
TspCOW1_15740	COG0494	nUDIX hydrolase
TspCOW1_15750	COG1196	nuclear chromosome segregation
TspCOW1_15750	COG0741	lytic transglycosylase activity
TspCOW1_15750	COG0739	heme binding
TspCOW1_15760	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
TspCOW1_15780	COG3002	Belongs to the UPF0753 family
TspCOW1_15800	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
TspCOW1_15870	COG5002	protein histidine kinase activity
TspCOW1_15870	COG2205	protein histidine kinase activity
TspCOW1_15870	COG0784	Response regulator, receiver
TspCOW1_15880	COG0736	holo-[acyl-carrier-protein] synthase activity
TspCOW1_15890	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
TspCOW1_15900	COG1381	Involved in DNA repair and RecF pathway recombination
TspCOW1_15910	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
TspCOW1_15920	COG0571	ribonuclease III activity
TspCOW1_15940	COG0681	Belongs to the peptidase S26 family
TspCOW1_15950	COG0481	GTPase activity
TspCOW1_15970	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
TspCOW1_15990	COG3026	antisigma factor binding
TspCOW1_16030	COG1254	Belongs to the acylphosphatase family
TspCOW1_16040	COG1566	PFAM secretion protein HlyD family protein
TspCOW1_16070	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
TspCOW1_16110	COG1393	Belongs to the ArsC family
TspCOW1_16150	COG0628	permease
TspCOW1_16160	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
TspCOW1_16180	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
TspCOW1_16190	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
TspCOW1_16210	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
TspCOW1_16220	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
TspCOW1_16230	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
TspCOW1_16240	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
TspCOW1_16250	COG0271	Belongs to the BolA IbaG family
TspCOW1_16260	COG3113	response to antibiotic
TspCOW1_16270	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
TspCOW1_16280	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
TspCOW1_16290	COG1127	ABC transporter
TspCOW1_16340	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
TspCOW1_16360	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
TspCOW1_16370	COG1137	ATPase activity
TspCOW1_16380	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
TspCOW1_16420	COG1660	Displays ATPase and GTPase activities
TspCOW1_16440	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
TspCOW1_16450	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
TspCOW1_16460	COG2239	Acts as a magnesium transporter
TspCOW1_16480	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
TspCOW1_16490	COG1350	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
TspCOW1_16510	COG0312	modulator of DNA gyrase
TspCOW1_16530	COG3028	Belongs to the UPF0307 family
TspCOW1_16600	COG0312	modulator of DNA gyrase
TspCOW1_16630	COG3164	Protein of unknown function
TspCOW1_16640	COG1530	ribonuclease E activity
TspCOW1_16660	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
TspCOW1_16680	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
TspCOW1_16690	COG1466	dna polymerase III delta subunit
TspCOW1_16710	COG0495	leucyl-tRNA aminoacylation
TspCOW1_16740	COG0815	Transfers the fatty acyl group on membrane lipoproteins
TspCOW1_16750	COG4535	Mg2 and Co2 transporter CorC
TspCOW1_16760	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
TspCOW1_16770	COG1702	phosphate starvation-inducible protein PhoH
TspCOW1_16780	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
TspCOW1_16800	COG0166	Belongs to the GPI family
TspCOW1_16810	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
TspCOW1_16820	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
TspCOW1_16830	COG0297	glycogen (starch) synthase activity
TspCOW1_16840	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
TspCOW1_16860	COG0717	Belongs to the dCTP deaminase family
TspCOW1_16870	COG0489	protein tyrosine kinase activity
TspCOW1_16880	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
TspCOW1_16880	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
TspCOW1_16890	COG4657	Part of a membrane complex involved in electron transport
TspCOW1_16900	COG2878	Part of a membrane complex involved in electron transport
TspCOW1_16920	COG4658	electron transport chain
TspCOW1_16930	COG4659	FMN binding
TspCOW1_16940	COG4660	Part of a membrane complex involved in electron transport
TspCOW1_16950	COG5002	protein histidine kinase activity
TspCOW1_16950	COG5001	Diguanylate cyclase
TspCOW1_16960	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
TspCOW1_16980	COG3220	belongs to the UPF0276 family
TspCOW1_17000	COG2259	Doxx family
TspCOW1_17010	COG0248	Ppx GppA phosphatase
TspCOW1_17050	COG0745	RESPONSE REGULATOR receiver
TspCOW1_17100	COG3577	Aspartyl protease
TspCOW1_17110	COG1115	amino acid carrier protein
TspCOW1_17130	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
TspCOW1_17220	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
TspCOW1_17230	COG1116	anion transmembrane transporter activity
TspCOW1_17240	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
TspCOW1_17250	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
TspCOW1_17260	COG3604	Transcriptional regulator
TspCOW1_17300	COG0367	asparagine synthase
TspCOW1_17310	COG0540	Belongs to the ATCase OTCase family
TspCOW1_17330	COG1335	isochorismatase
TspCOW1_17370	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
TspCOW1_17500	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
TspCOW1_17520	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
TspCOW1_17530	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
TspCOW1_17540	COG0196	riboflavin kinase activity
TspCOW1_17560	COG0268	Binds directly to 16S ribosomal RNA
TspCOW1_17570	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
TspCOW1_17580	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
TspCOW1_17600	COG0261	This protein binds to 23S rRNA in the presence of protein L20
TspCOW1_17610	COG0142	geranyltranstransferase activity
TspCOW1_17620	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
TspCOW1_17630	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
TspCOW1_17670	COG3209	COG3209 Rhs family protein
TspCOW1_17680	COG3209	COG3209 Rhs family protein
TspCOW1_17700	COG3209	COG3209 Rhs family protein
TspCOW1_17720	COG3209	COG3209 Rhs family protein
TspCOW1_17740	COG3209	COG3209 Rhs family protein
TspCOW1_17750	COG3209	COG3209 Rhs family protein
TspCOW1_17790	COG1704	LemA family
TspCOW1_17830	COG1959	2 iron, 2 sulfur cluster binding
TspCOW1_17840	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
TspCOW1_17850	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
TspCOW1_17910	COG0484	heat shock protein binding
TspCOW1_17950	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
TspCOW1_18050	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
TspCOW1_18060	COG1047	Peptidyl-prolyl cis-trans
TspCOW1_18070	COG3842	ATPase activity
TspCOW1_18080	COG1178	ABC-type Fe3 transport system permease component
TspCOW1_18090	COG1840	ABC-type Fe3 transport system, periplasmic component
TspCOW1_18100	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
TspCOW1_18110	COG0483	inositol monophosphate 1-phosphatase activity
TspCOW1_18170	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
TspCOW1_18180	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
TspCOW1_18200	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
TspCOW1_18210	COG2020	methyltransferase activity
TspCOW1_18230	COG1959	2 iron, 2 sulfur cluster binding
TspCOW1_18260	COG0494	nUDIX hydrolase
TspCOW1_18300	COG4772	TonB-dependent receptor
TspCOW1_18310	COG2205	protein histidine kinase activity
TspCOW1_18310	COG0745	RESPONSE REGULATOR receiver
TspCOW1_18310	COG4191	Histidine kinase
TspCOW1_18340	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
TspCOW1_18360	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
TspCOW1_18440	COG0406	alpha-ribazole phosphatase activity
TspCOW1_18480	COG0129	dihydroxy-acid dehydratase activity
TspCOW1_18490	COG0840	transmembrane signaling receptor activity
TspCOW1_18500	COG0189	ligase activity
TspCOW1_18540	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
TspCOW1_18610	COG3031	protein transport across the cell outer membrane
TspCOW1_18650	COG0151	Belongs to the GarS family
TspCOW1_18660	COG0138	bifunctional purine biosynthesis protein purh
TspCOW1_18670	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
TspCOW1_18700	COG2264	protein methyltransferase activity
TspCOW1_18710	COG0439	Biotin carboxylase
TspCOW1_18730	COG0511	ligase activity, forming carbon-carbon bonds
TspCOW1_18740	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
TspCOW1_18840	COG4964	Belongs to the GSP D family
TspCOW1_18890	COG2203	Gaf domain
TspCOW1_18890	COG3706	GGDEF domain
TspCOW1_18890	COG5001	Diguanylate cyclase
TspCOW1_18890	COG4251	negative regulation of phosphorylation
TspCOW1_18910	COG2197	response regulator
TspCOW1_19050	COG0489	protein tyrosine kinase activity
TspCOW1_19060	COG3267	Type II secretory pathway component ExeA
TspCOW1_19060	COG3409	Peptidoglycan-binding domain 1 protein
TspCOW1_19080	COG1218	3'(2'),5'-bisphosphate nucleotidase
TspCOW1_19090	COG0494	nUDIX hydrolase
TspCOW1_19100	COG1011	Hydrolase
TspCOW1_19220	COG0352	thiamine-phosphate diphosphorylase activity
TspCOW1_19230	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
TspCOW1_19240	COG0586	Pfam SNARE associated Golgi protein
TspCOW1_19270	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
TspCOW1_19290	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
TspCOW1_19300	COG0563	adenylate kinase activity
TspCOW1_19310	COG0205	6-phosphofructokinase activity
TspCOW1_19320	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
TspCOW1_19330	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
TspCOW1_19350	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
TspCOW1_19360	COG0315	cyclic pyranopterin monophosphate synthase activity
TspCOW1_19420	COG1639	'signal transduction protein
TspCOW1_19480	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
TspCOW1_19490	COG3706	GGDEF domain
TspCOW1_19510	COG1187	pseudouridine synthase activity
TspCOW1_19530	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
TspCOW1_19580	COG0488	(ABC) transporter
TspCOW1_19600	COG1403	HNH endonuclease
TspCOW1_19610	COG3360	Dodecin
TspCOW1_19620	COG4572	Cation transport regulator
TspCOW1_19630	COG0446	pyridine nucleotide-disulphide oxidoreductase
TspCOW1_19670	COG0583	DNA-binding transcription factor activity
TspCOW1_19680	COG0659	secondary active sulfate transmembrane transporter activity
TspCOW1_19730	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
TspCOW1_19740	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
TspCOW1_19750	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
TspCOW1_19760	COG4576	ethanolamine utilization protein EutN carboxysome structural protein Ccml
TspCOW1_19800	COG4451	ribulose bisphosphate carboxylase, small
TspCOW1_19810	COG1850	ribulose-bisphosphate carboxylase activity
TspCOW1_19820	COG2010	Cytochrome c
TspCOW1_19830	COG0513	Belongs to the DEAD box helicase family
TspCOW1_19870	COG0577	efflux transmembrane transporter activity
TspCOW1_19870	COG1136	(ABC) transporter
TspCOW1_19880	COG4251	negative regulation of phosphorylation
TspCOW1_19880	COG3706	GGDEF domain
TspCOW1_19880	COG2203	Gaf domain
TspCOW1_19880	COG5001	Diguanylate cyclase
TspCOW1_19890	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
TspCOW1_19920	COG0490	domain, Protein
TspCOW1_19920	COG2985	domain, Protein
TspCOW1_19960	COG1902	pentaerythritol trinitrate reductase activity
TspCOW1_19980	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
TspCOW1_20010	COG4176	ABC-type proline glycine betaine transport system permease component
TspCOW1_20020	COG4175	Glycine betaine
TspCOW1_20040	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
TspCOW1_20170	COG5001	Diguanylate cyclase
TspCOW1_20260	COG0433	COG0433 Predicted ATPase
TspCOW1_20320	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
TspCOW1_20380	COG2329	Antibiotic biosynthesis monooxygenase
TspCOW1_20500	COG1970	mechanosensitive ion channel activity
TspCOW1_20530	COG0425	Belongs to the sulfur carrier protein TusA family
TspCOW1_20590	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
TspCOW1_20610	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
TspCOW1_20660	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
TspCOW1_20680	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
TspCOW1_20690	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
TspCOW1_20700	COG1538	Outer membrane efflux protein
TspCOW1_20720	COG1519	Transferase
TspCOW1_20730	COG1560	Kdo2-lipid A biosynthetic process
TspCOW1_20830	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
TspCOW1_20860	COG1595	DNA-templated transcription, initiation
TspCOW1_20880	COG0459	protein refolding
TspCOW1_20890	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
TspCOW1_20910	COG1324	tolerance protein
TspCOW1_20920	COG4232	protein-disulfide reductase activity
TspCOW1_20930	COG2827	Endonuclease containing a URI domain
TspCOW1_20940	COG2204	response regulator
TspCOW1_20950	COG0784	Response regulator, receiver
TspCOW1_20950	COG2205	protein histidine kinase activity
TspCOW1_20950	COG2198	Histidine kinase
TspCOW1_20970	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
TspCOW1_20990	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
TspCOW1_21100	COG0110	maltose O-acetyltransferase activity
TspCOW1_21290	COG2046	Belongs to the sulfate adenylyltransferase family
TspCOW1_21290	COG0529	Catalyzes the synthesis of activated sulfate
TspCOW1_21390	COG2189	Belongs to the N(4) N(6)-methyltransferase family
TspCOW1_21630	COG5642	Protein of unknown function (DUF2384)
TspCOW1_21670	COG0489	protein tyrosine kinase activity
TspCOW1_21750	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
TspCOW1_21760	COG1194	a g-specific adenine glycosylase
TspCOW1_21770	COG2982	Protein involved in outer membrane biogenesis
TspCOW1_21790	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
TspCOW1_21830	COG1022	Amp-dependent synthetase and ligase
TspCOW1_21850	COG2022	thiamine diphosphate biosynthetic process
TspCOW1_21860	COG0598	Magnesium transport protein CorA
TspCOW1_21870	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
TspCOW1_21870	COG3264	Mechanosensitive ion channel
TspCOW1_21880	COG0220	tRNA (guanine-N7-)-methyltransferase activity
TspCOW1_21890	COG3954	Phosphoribulokinase
TspCOW1_21910	COG0667	Aldo Keto reductase
TspCOW1_21930	COG1612	heme a metabolic process
TspCOW1_22000	COG2204	response regulator
TspCOW1_22010	COG3852	Histidine kinase
TspCOW1_22080	COG2217	Heavy metal translocating P-type atpase
TspCOW1_22090	COG2258	MOSC domain
TspCOW1_22160	COG2132	Multicopper oxidase
TspCOW1_22200	COG2801	Transposase and inactivated derivatives
TspCOW1_22220	COG0697	spore germination
TspCOW1_22230	COG2217	Heavy metal translocating P-type atpase
TspCOW1_22290	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
TspCOW1_22300	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
TspCOW1_22330	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
TspCOW1_22340	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
TspCOW1_22350	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
TspCOW1_22400	COG2813	Specifically methylates the guanine in position
TspCOW1_22450	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
TspCOW1_22460	COG0243	molybdopterin cofactor binding
TspCOW1_22470	COG0437	4 iron, 4 sulfur cluster binding
TspCOW1_22480	COG3302	dmso reductase anchor subunit
TspCOW1_22490	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
TspCOW1_22500	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
TspCOW1_22510	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
TspCOW1_22520	COG3154	lipid carrier protein
TspCOW1_22560	COG0826	peptidase U32
TspCOW1_22570	COG0826	peptidase U32
TspCOW1_22580	COG1242	4 iron, 4 sulfur cluster binding
TspCOW1_22650	COG1845	cytochrome c oxidase, subunit III
TspCOW1_22670	COG2010	Cytochrome c
TspCOW1_22710	COG0535	radical SAM domain protein
TspCOW1_22780	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
TspCOW1_22780	COG1648	precorrin-2 dehydrogenase activity
TspCOW1_22800	COG0730	response to heat
TspCOW1_22810	COG1012	belongs to the aldehyde dehydrogenase family
TspCOW1_22820	COG1196	nuclear chromosome segregation
TspCOW1_22820	COG0741	lytic transglycosylase activity
TspCOW1_22820	COG0739	heme binding
TspCOW1_22850	COG1320	monovalent cation:proton antiporter activity
TspCOW1_22880	COG0651	ATP synthesis coupled electron transport
TspCOW1_22890	COG0651	ATP synthesis coupled electron transport
TspCOW1_22900	COG0651	ATP synthesis coupled electron transport
TspCOW1_22920	COG0617	tRNA 3'-terminal CCA addition
TspCOW1_22940	COG1968	undecaprenyl-diphosphatase activity
TspCOW1_22970	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
TspCOW1_22980	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
TspCOW1_23000	COG0828	Belongs to the bacterial ribosomal protein bS21 family
TspCOW1_23010	COG1610	YqeY-like protein
TspCOW1_23020	COG0358	DNA primase activity
TspCOW1_23040	COG1280	lysine exporter protein (LysE YggA)
TspCOW1_23060	COG5642	Protein of unknown function (DUF2384)
TspCOW1_23070	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
TspCOW1_23130	COG4263	nitrous-oxide reductase activity
TspCOW1_23140	COG3901	Regulator of nitric oxide reductase transcription
TspCOW1_23140	COG0348	domain, Protein
TspCOW1_23190	COG1278	Cold shock
TspCOW1_23220	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
TspCOW1_23240	COG2827	Endonuclease containing a URI domain
TspCOW1_23270	COG3706	GGDEF domain
TspCOW1_23320	COG0189	ligase activity
TspCOW1_23350	COG0521	Mo-molybdopterin cofactor biosynthetic process
TspCOW1_23440	COG1131	(ABC) transporter
TspCOW1_23450	COG0842	Transport permease protein
TspCOW1_23500	COG2010	Cytochrome c
TspCOW1_23530	COG3278	Belongs to the heme-copper respiratory oxidase family
TspCOW1_23540	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
TspCOW1_23550	COG0131	Imidazoleglycerol-phosphate dehydratase
TspCOW1_23560	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
TspCOW1_23570	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
TspCOW1_23580	COG0107	imidazoleglycerol-phosphate synthase activity
TspCOW1_23590	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
TspCOW1_23600	COG0140	phosphoribosyl-ATP diphosphatase activity
TspCOW1_23610	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
TspCOW1_23620	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
TspCOW1_23660	COG0435	Glutathione S-transferase
TspCOW1_23710	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
TspCOW1_23720	COG1333	cytochrome c biogenesis protein
TspCOW1_23740	COG0218	Necessary for normal cell division and for the maintenance of normal septation
TspCOW1_23760	COG1611	Belongs to the LOG family
TspCOW1_23820	COG2922	Belongs to the Smg family
TspCOW1_23830	COG0758	DNA mediated transformation
TspCOW1_23850	COG0242	peptide deformylase activity
TspCOW1_23860	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
TspCOW1_23890	COG5000	phosphorelay sensor kinase activity
TspCOW1_23900	COG2204	response regulator
TspCOW1_23910	COG0569	domain protein
TspCOW1_23920	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
TspCOW1_23980	COG3189	MarR family transcriptional regulator
TspCOW1_24000	COG0037	tRNA processing
TspCOW1_24020	COG2210	Belongs to the sulfur carrier protein TusA family
TspCOW1_24040	COG1490	D-aminoacyl-tRNA deacylase activity
TspCOW1_24090	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
TspCOW1_24110	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
TspCOW1_24110	COG0543	2 iron, 2 sulfur cluster binding
TspCOW1_24150	COG0181	hydroxymethylbilane synthase activity
TspCOW1_24180	COG2972	Histidine kinase
TspCOW1_24180	COG0745	RESPONSE REGULATOR receiver
TspCOW1_24190	COG0165	Argininosuccinate lyase
TspCOW1_24200	COG5001	Diguanylate cyclase
TspCOW1_24200	COG5002	protein histidine kinase activity
TspCOW1_24270	COG1943	Transposase
TspCOW1_24330	COG3706	GGDEF domain
TspCOW1_24340	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
TspCOW1_24380	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
TspCOW1_24400	COG0583	DNA-binding transcription factor activity
TspCOW1_24420	COG0730	response to heat
TspCOW1_24460	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
TspCOW1_24480	COG2861	carbohydrate metabolic process
TspCOW1_24490	COG0793	Belongs to the peptidase S41A family
TspCOW1_24500	COG4942	peptidase
TspCOW1_24510	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
TspCOW1_24540	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
TspCOW1_24550	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
TspCOW1_24560	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
TspCOW1_24570	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
TspCOW1_24590	COG0606	chelatase, subunit chli
TspCOW1_24610	COG0347	Belongs to the P(II) protein family
TspCOW1_24620	COG0004	ammonium transporteR
TspCOW1_24640	COG0009	L-threonylcarbamoyladenylate synthase
TspCOW1_24650	COG3706	GGDEF domain
TspCOW1_24670	COG1773	rubredoxin
TspCOW1_24720	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
TspCOW1_24750	COG4206	TonB-dependent receptor
TspCOW1_24770	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
TspCOW1_24780	COG0488	(ABC) transporter
TspCOW1_24830	COG0438	transferase activity, transferring glycosyl groups
TspCOW1_24840	COG0438	transferase activity, transferring glycosyl groups
TspCOW1_24850	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
TspCOW1_24860	COG1509	lysine 2,3-aminomutase activity
TspCOW1_24880	COG1846	Transcriptional regulator
TspCOW1_24940	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
TspCOW1_24970	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
TspCOW1_24980	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
TspCOW1_24990	COG1047	Peptidyl-prolyl cis-trans
TspCOW1_25000	COG0355	proton-transporting ATP synthase activity, rotational mechanism
TspCOW1_25010	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
TspCOW1_25020	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
TspCOW1_25030	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
TspCOW1_25040	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
TspCOW1_25050	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
TspCOW1_25070	COG0356	it plays a direct role in the translocation of protons across the membrane
TspCOW1_25090	COG1475	DNA binding
TspCOW1_25100	COG1192	Involved in chromosome partitioning
TspCOW1_25110	COG0357	Ribosomal RNA small subunit methyltransferase G
TspCOW1_25120	COG0445	tRNA wobble uridine modification
TspCOW1_25150	COG0714	Associated with various cellular activities
TspCOW1_25210	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
TspCOW1_25220	COG0706	membrane insertase activity
TspCOW1_25230	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
TspCOW1_25240	COG0594	ribonuclease P activity
TspCOW1_25250	COG0230	Belongs to the bacterial ribosomal protein bL34 family
TspCOW1_25260	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
TspCOW1_25280	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
TspCOW1_25310	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
TspCOW1_25330	COG0751	glycine-tRNA ligase activity
TspCOW1_25340	COG0752	glycyl-tRNA synthetase alpha subunit
TspCOW1_25360	COG0482	sulfurtransferase activity
TspCOW1_25390	COG0174	glutamine synthetase
TspCOW1_25420	COG3852	Histidine kinase
TspCOW1_25430	COG2204	response regulator
TspCOW1_25490	COG2165	general secretion pathway protein
TspCOW1_25500	COG1459	type II secretion system
TspCOW1_25510	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
TspCOW1_25540	COG1450	Type ii and iii secretion system protein
TspCOW1_25580	COG0167	dihydroorotate dehydrogenase activity
TspCOW1_25590	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
TspCOW1_25630	COG0210	DNA helicase
TspCOW1_25700	COG4520	surface antigen
TspCOW1_25730	COG3094	Invasion gene expression up-regulator, SirB
TspCOW1_25760	COG0543	2 iron, 2 sulfur cluster binding
TspCOW1_25760	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
TspCOW1_25780	COG0672	)-iron permease
TspCOW1_25800	COG0123	including yeast histone deacetylase and acetoin utilization protein
TspCOW1_25810	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
TspCOW1_25810	COG1042	CoA-binding domain protein
TspCOW1_25810	COG0045	succinate-CoA ligase (ADP-forming) activity
TspCOW1_25840	COG0517	IMP dehydrogenase activity
TspCOW1_25840	COG1125	glycine betaine transport
TspCOW1_25850	COG0791	NLP P60 protein
TspCOW1_25880	COG2703	oxygen carrier activity
TspCOW1_25900	COG2943	transferase activity, transferring hexosyl groups
TspCOW1_25920	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
TspCOW1_25960	COG1671	Belongs to the UPF0178 family
TspCOW1_25990	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
TspCOW1_26000	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
TspCOW1_26020	COG3153	acetyltransferase
TspCOW1_26030	COG3384	dioxygenase
TspCOW1_26060	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
TspCOW1_26070	COG1129	ABC transporter
TspCOW1_26070	COG0842	Transport permease protein
TspCOW1_26080	COG0842	Transport permease protein
TspCOW1_26100	COG0210	DNA helicase
TspCOW1_26120	COG5002	protein histidine kinase activity
TspCOW1_26120	COG5001	Diguanylate cyclase
TspCOW1_26130	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
TspCOW1_26140	COG1136	(ABC) transporter
TspCOW1_26150	COG0390	transport system, permease component
TspCOW1_26160	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
TspCOW1_26170	COG1166	arginine decarboxylase activity
TspCOW1_26180	COG2084	Dehydrogenase
TspCOW1_26210	COG4772	TonB-dependent receptor
TspCOW1_26230	COG0018	arginyl-trna synthetase
TspCOW1_26240	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
TspCOW1_26300	COG3001	Fructosamine kinase
TspCOW1_26330	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
TspCOW1_26350	COG0069	glutamate synthase activity
TspCOW1_26350	COG0070	glutamate synthase
TspCOW1_26350	COG0067	glutamate synthase
TspCOW1_26380	COG0232	Belongs to the dGTPase family. Type 2 subfamily
TspCOW1_26390	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
TspCOW1_26400	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
TspCOW1_26480	COG0281	malic enzyme
TspCOW1_26510	COG0254	rRNA binding
TspCOW1_26530	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
TspCOW1_26560	COG0635	Involved in the biosynthesis of porphyrin-containing compound
TspCOW1_26570	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
TspCOW1_26580	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
TspCOW1_26590	COG0631	protein serine/threonine phosphatase activity
TspCOW1_26600	COG2815	serine threonine protein kinase
TspCOW1_26600	COG0515	serine threonine protein kinase
TspCOW1_26610	COG1561	YicC-like family, N-terminal region
TspCOW1_26620	COG0194	GDP metabolic process
TspCOW1_26630	COG1758	RNA polymerase activity
TspCOW1_26640	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
TspCOW1_26660	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
TspCOW1_26670	COG3161	chorismate lyase activity
TspCOW1_26680	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
TspCOW1_26720	COG1040	competence protein
TspCOW1_26740	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
TspCOW1_26750	COG0156	8-amino-7-oxononanoate synthase activity
TspCOW1_26760	COG0596	Alpha beta hydrolase
TspCOW1_26770	COG2226	methyltransferase
TspCOW1_26810	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
TspCOW1_26850	COG3346	SURF1 family
TspCOW1_26870	COG0109	protoheme IX farnesyltransferase activity
TspCOW1_26880	COG3278	Belongs to the heme-copper respiratory oxidase family
TspCOW1_26910	COG2010	Cytochrome c
TspCOW1_26920	COG0348	domain, Protein
TspCOW1_26940	COG2217	Heavy metal translocating P-type atpase
TspCOW1_27030	COG2801	Transposase and inactivated derivatives
TspCOW1_27070	COG2801	Transposase and inactivated derivatives
TspCOW1_27110	COG0450	alkyl hydroperoxide reductase
TspCOW1_27120	COG0425	Belongs to the sulfur carrier protein TusA family
TspCOW1_27130	COG2391	methyltransferase activity
TspCOW1_27240	COG3852	Histidine kinase
TspCOW1_27250	COG2204	response regulator
TspCOW1_27290	COG1278	Cold shock
TspCOW1_27300	COG0724	RNA recognition motif
TspCOW1_27340	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
TspCOW1_27390	COG2177	Part of the ABC transporter FtsEX involved in
TspCOW1_27400	COG2884	Cell division ATP-binding protein ftsE
TspCOW1_27410	COG0552	protein localization to endoplasmic reticulum
TspCOW1_27420	COG0612	Peptidase, M16
TspCOW1_27430	COG0612	Peptidase, M16
TspCOW1_27450	COG0742	ribosomal rna small subunit methyltransferase
TspCOW1_27460	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
TspCOW1_27470	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
TspCOW1_27500	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
TspCOW1_27510	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
TspCOW1_27550	COG1131	(ABC) transporter
TspCOW1_27570	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
TspCOW1_27590	COG0267	Belongs to the bacterial ribosomal protein bL33 family
TspCOW1_27600	COG0227	Belongs to the bacterial ribosomal protein bL28 family
TspCOW1_27610	COG2003	Belongs to the UPF0758 family
TspCOW1_27620	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
TspCOW1_27630	COG0756	dUTP diphosphatase activity
TspCOW1_27650	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
TspCOW1_27680	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
TspCOW1_27690	COG0708	Exodeoxyribonuclease III
TspCOW1_27730	COG1872	DUF167
TspCOW1_27820	COG0540	Belongs to the ATCase OTCase family
TspCOW1_27840	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
TspCOW1_27850	COG1678	Uncharacterized ACR, COG1678
TspCOW1_27900	COG0189	ligase activity
TspCOW1_27950	COG0840	transmembrane signaling receptor activity
TspCOW1_27970	COG0784	Response regulator, receiver
TspCOW1_27970	COG0643	Histidine kinase
TspCOW1_27970	COG2198	Histidine kinase
TspCOW1_27980	COG2201	protein-glutamate methylesterase activity
TspCOW1_28000	COG0471	metal ion transport
TspCOW1_28030	COG2204	response regulator
TspCOW1_28050	COG1385	rRNA (uridine-N3-)-methyltransferase activity
TspCOW1_28060	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
TspCOW1_28070	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
TspCOW1_28080	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
TspCOW1_28110	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
TspCOW1_28120	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
TspCOW1_28130	COG0126	phosphoglycerate kinase activity
TspCOW1_28140	COG0469	pyruvate kinase activity
TspCOW1_28150	COG0191	fructose-bisphosphate aldolase activity
TspCOW1_28180	COG0475	glutathione-regulated potassium exporter activity
TspCOW1_28210	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
TspCOW1_28340	COG0071	Belongs to the small heat shock protein (HSP20) family
TspCOW1_28360	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
TspCOW1_28410	COG3409	Peptidoglycan-binding domain 1 protein
TspCOW1_28410	COG3267	Type II secretory pathway component ExeA
TspCOW1_28460	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
TspCOW1_28490	COG1515	deoxyribonuclease V activity
TspCOW1_28510	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
TspCOW1_28550	COG0546	phosphoglycolate phosphatase activity
TspCOW1_28570	COG0512	Glutamine amidotransferase of anthranilate synthase
TspCOW1_28580	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
TspCOW1_28590	COG0134	indole-3-glycerol-phosphate synthase activity
TspCOW1_28610	COG1765	OsmC-like protein
TspCOW1_28630	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
TspCOW1_28640	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
TspCOW1_28660	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
TspCOW1_28670	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
TspCOW1_28680	COG3047	cAMP biosynthetic process
TspCOW1_28700	COG0247	lactate metabolic process
TspCOW1_28710	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
TspCOW1_28720	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
TspCOW1_28750	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
TspCOW1_28790	COG0006	proline dipeptidase activity
TspCOW1_28800	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
TspCOW1_28810	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
TspCOW1_28830	COG0404	The glycine cleavage system catalyzes the degradation of glycine
TspCOW1_28840	COG0509	glycine decarboxylation via glycine cleavage system
TspCOW1_28850	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
TspCOW1_28860	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
TspCOW1_28870	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
TspCOW1_28880	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
TspCOW1_28890	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
TspCOW1_28920	COG1309	transcriptional regulator
TspCOW1_28930	COG0425	Belongs to the sulfur carrier protein TusA family
TspCOW1_28940	COG2824	Alkylphosphonate utilization operon protein PhnA
TspCOW1_28950	COG1331	Highly conserved protein containing a thioredoxin domain
TspCOW1_28960	COG0463	Glycosyl transferase, family 2
TspCOW1_29020	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
TspCOW1_29060	COG2967	ApaG domain
TspCOW1_29070	COG0837	glucose binding
TspCOW1_29080	COG0363	glucosamine-6-phosphate deaminase activity
TspCOW1_29110	COG0589	response to stress
TspCOW1_29130	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
TspCOW1_29140	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
TspCOW1_29150	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
TspCOW1_29160	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
TspCOW1_29190	COG3178	'Phosphotransferase
TspCOW1_29200	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
TspCOW1_29260	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
TspCOW1_29310	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
TspCOW1_29320	COG0321	lipoyl(octanoyl) transferase activity
TspCOW1_29330	COG2921	Belongs to the UPF0250 family
TspCOW1_29390	COG1686	Belongs to the peptidase S11 family
TspCOW1_29410	COG2951	lytic endotransglycosylase activity
TspCOW1_29420	COG0772	Belongs to the SEDS family
TspCOW1_29430	COG0768	penicillin binding
TspCOW1_29440	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
TspCOW1_29450	COG1792	Involved in formation and maintenance of cell shape
TspCOW1_29460	COG1077	Cell shape determining protein MreB Mrl
TspCOW1_29470	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
TspCOW1_29480	COG0154	amidase activity
TspCOW1_29490	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
TspCOW1_29510	COG0561	phosphatase activity
TspCOW1_29510	COG3100	YcgL domain-containing protein
TspCOW1_29520	COG3647	Membrane
TspCOW1_29540	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
TspCOW1_29560	COG2890	protein-(glutamine-N5) methyltransferase activity
TspCOW1_29570	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
TspCOW1_29580	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
TspCOW1_29600	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
TspCOW1_29610	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
TspCOW1_29620	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
TspCOW1_29630	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
TspCOW1_29640	COG0193	aminoacyl-tRNA hydrolase activity
TspCOW1_29650	COG0012	GTP binding
TspCOW1_29860	COG0582	viral genome integration into host DNA
TspCOW1_29870	COG1104	cysteine desulfurase activity
TspCOW1_29890	COG2226	methyltransferase
TspCOW1_29930	COG0647	UMP catabolic process
TspCOW1_30030	COG1518	maintenance of DNA repeat elements
TspCOW1_30030	COG1468	defense response to virus
TspCOW1_30040	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
TspCOW1_30050	COG2204	response regulator
TspCOW1_30070	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
TspCOW1_30120	COG1331	Highly conserved protein containing a thioredoxin domain
TspCOW1_30150	COG1444	tRNA N-acetyltransferase activity
TspCOW1_30180	COG2270	Major facilitator Superfamily
TspCOW1_30200	COG1643	Atp-dependent helicase
TspCOW1_30240	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
TspCOW1_30330	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
TspCOW1_30360	COG0432	Pfam Uncharacterised protein family UPF0047
TspCOW1_30380	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
TspCOW1_30390	COG2096	Adenosyltransferase
TspCOW1_30410	COG4206	TonB-dependent receptor
TspCOW1_30440	COG1120	ATPase activity
TspCOW1_30470	COG0494	nUDIX hydrolase
TspCOW1_30480	COG3605	phosphoenolpyruvate-protein phosphotransferase activity
TspCOW1_30520	COG1981	membrane
TspCOW1_30530	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
TspCOW1_30560	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
TspCOW1_30590	COG0316	Belongs to the HesB IscA family
TspCOW1_30620	COG0739	heme binding
TspCOW1_30630	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
TspCOW1_30660	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
TspCOW1_30660	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
TspCOW1_30670	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
TspCOW1_30700	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
TspCOW1_30710	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
TspCOW1_30740	COG0004	ammonium transporteR
TspCOW1_30750	COG0697	spore germination
TspCOW1_30780	COG2738	Putative neutral zinc metallopeptidase
TspCOW1_30820	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
TspCOW1_30850	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
TspCOW1_30860	COG0081	regulation of translation
TspCOW1_30870	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
TspCOW1_30880	COG0222	ribosome binding
TspCOW1_30890	COG0085	RNA polymerase activity
TspCOW1_30900	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
TspCOW1_30910	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
TspCOW1_30920	COG0049	tRNA binding
TspCOW1_30930	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
TspCOW1_30940	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
TspCOW1_30970	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
TspCOW1_30980	COG0081	regulation of translation
TspCOW1_30990	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
TspCOW1_31000	COG0222	ribosome binding
TspCOW1_31010	COG0085	RNA polymerase activity
TspCOW1_31020	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
TspCOW1_31030	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
TspCOW1_31040	COG0049	tRNA binding
TspCOW1_31050	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
TspCOW1_31060	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
TspCOW1_31070	COG0051	transcription antitermination factor activity, RNA binding
TspCOW1_31080	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
TspCOW1_31090	COG0088	Forms part of the polypeptide exit tunnel
TspCOW1_31100	COG0089	rRNA binding
TspCOW1_31110	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
TspCOW1_31120	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
TspCOW1_31130	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
TspCOW1_31140	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
TspCOW1_31150	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
TspCOW1_31160	COG0255	Belongs to the universal ribosomal protein uL29 family
TspCOW1_31170	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
TspCOW1_31180	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
TspCOW1_31190	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
TspCOW1_31200	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
TspCOW1_31210	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
TspCOW1_31220	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
TspCOW1_31230	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
TspCOW1_31240	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
TspCOW1_31250	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
TspCOW1_31260	COG1841	ribosomal large subunit assembly
TspCOW1_31270	COG0200	Binds to the 23S rRNA
TspCOW1_31280	COG0201	protein transport
TspCOW1_31290	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
TspCOW1_31300	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
TspCOW1_31310	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
TspCOW1_31320	COG0202	RNA polymerase activity
TspCOW1_31330	COG0203	ribosomal protein L17
TspCOW1_31360	COG2814	Major facilitator Superfamily
TspCOW1_31370	COG0629	single-stranded DNA binding
TspCOW1_31390	COG2001	Belongs to the MraZ family
TspCOW1_31400	COG0275	rRNA processing
TspCOW1_31410	COG3116	cell division
TspCOW1_31440	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
TspCOW1_31450	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
TspCOW1_31460	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
TspCOW1_31470	COG0772	Belongs to the SEDS family
TspCOW1_31480	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
TspCOW1_31490	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
TspCOW1_31510	COG0812	UDP-N-acetylmuramate dehydrogenase activity
TspCOW1_31520	COG1181	Belongs to the D-alanine--D-alanine ligase family
TspCOW1_31550	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
TspCOW1_31560	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
TspCOW1_31580	COG0739	heme binding
TspCOW1_31590	COG0653	protein targeting
TspCOW1_31610	COG0494	nUDIX hydrolase
TspCOW1_31640	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
TspCOW1_31650	COG0237	dephospho-CoA kinase activity
TspCOW1_31660	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
TspCOW1_31710	COG0438	transferase activity, transferring glycosyl groups
TspCOW1_31800	COG0045	succinate-CoA ligase (ADP-forming) activity
TspCOW1_31810	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
TspCOW1_31850	COG0564	pseudouridine synthase activity
TspCOW1_31880	COG3830	Belongs to the UPF0237 family
TspCOW1_31890	COG0242	peptide deformylase activity
TspCOW1_31910	COG0542	response to heat
TspCOW1_31940	COG0300	oxidoreductase activity
TspCOW1_31960	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
TspCOW1_31970	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
TspCOW1_31980	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
TspCOW1_31990	COG1360	Flagellar Motor Protein
TspCOW1_32050	COG5265	(ABC) transporter
TspCOW1_32080	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
TspCOW1_32090	COG0442	prolyl-tRNA aminoacylation
TspCOW1_32110	COG0028	Belongs to the TPP enzyme family
TspCOW1_32120	COG0440	acetolactate synthase activity
TspCOW1_32130	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
TspCOW1_32150	COG0688	phosphatidylethanolamine metabolic process
TspCOW1_32160	COG1183	phosphatidylcholine synthase activity
TspCOW1_32170	COG3437	response regulator, receiver
TspCOW1_32220	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
TspCOW1_32230	COG1573	uracil-dna glycosylase
TspCOW1_32250	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
TspCOW1_32260	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
TspCOW1_32310	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
TspCOW1_32330	COG0525	valine-tRNA ligase activity
TspCOW1_32350	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
TspCOW1_32360	COG0795	lipopolysaccharide-transporting ATPase activity
TspCOW1_32370	COG0795	lipopolysaccharide-transporting ATPase activity
TspCOW1_32380	COG1714	RDD family
TspCOW1_32420	COG0617	tRNA 3'-terminal CCA addition
TspCOW1_32440	COG2255	four-way junction helicase activity
TspCOW1_32450	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
TspCOW1_32460	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
TspCOW1_32470	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
TspCOW1_32530	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
TspCOW1_32550	COG0418	dihydroorotase activity
TspCOW1_32560	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
TspCOW1_32570	COG0508	dehydrogenase complex catalyzes the overall conversion of
TspCOW1_32570	COG0022	dehydrogenase e1 component
TspCOW1_32580	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
TspCOW1_32600	COG0137	argininosuccinate synthase activity
TspCOW1_32630	COG0581	inorganic phosphate transmembrane transporter activity
TspCOW1_32640	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
TspCOW1_32660	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
TspCOW1_32670	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
TspCOW1_32710	COG0367	asparagine synthase
TspCOW1_32720	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
TspCOW1_32730	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
TspCOW1_32750	COG0723	plastoquinol--plastocyanin reductase activity
TspCOW1_32760	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
TspCOW1_32770	COG2857	Cytochrome c1
TspCOW1_32780	COG0625	glutathione transferase activity
TspCOW1_32790	COG2969	positive regulation of protein catabolic process
TspCOW1_32860	COG3549	Plasmid maintenance system killer
TspCOW1_32960	COG5002	protein histidine kinase activity
TspCOW1_32970	COG2199	diguanylate cyclase activity
TspCOW1_32970	COG2200	EAL domain
TspCOW1_32970	COG3287	FIST C domain
TspCOW1_32990	COG2823	Periplasmic or secreted lipoprotein
TspCOW1_33000	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
TspCOW1_33010	COG0792	nuclease activity
TspCOW1_33040	COG0826	peptidase U32
TspCOW1_33060	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
TspCOW1_33060	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
TspCOW1_33070	COG0802	atpase or kinase
TspCOW1_33080	COG0860	N-Acetylmuramoyl-L-alanine amidase
TspCOW1_33090	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
TspCOW1_33100	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
TspCOW1_33110	COG1923	regulation of RNA biosynthetic process
TspCOW1_33120	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
TspCOW1_33130	COG0330	HflC and HflK could
TspCOW1_33140	COG0330	HflC and HflK could
TspCOW1_33160	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
TspCOW1_33170	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
TspCOW1_33190	COG0557	exoribonuclease II activity
TspCOW1_33200	COG2885	chlorophyll binding
TspCOW1_33210	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
TspCOW1_33220	COG0360	Binds together with S18 to 16S ribosomal RNA
TspCOW1_33230	COG2965	DNA replication, synthesis of RNA primer
TspCOW1_33260	COG0359	binds to the 23S rRNA
TspCOW1_33270	COG0305	Participates in initiation and elongation during chromosome replication
TspCOW1_33280	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
TspCOW1_33350	COG4536	flavin adenine dinucleotide binding
TspCOW1_33360	COG4137	Cytochrome C assembly protein
TspCOW1_33380	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
TspCOW1_33390	COG0228	four-way junction DNA binding
TspCOW1_33400	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
TspCOW1_33410	COG0336	Belongs to the RNA methyltransferase TrmD family
TspCOW1_33420	COG0335	large ribosomal subunit rRNA binding
TspCOW1_33440	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
TspCOW1_33450	COG0326	Molecular chaperone. Has ATPase activity
TspCOW1_33460	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
TspCOW1_33470	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
TspCOW1_33480	COG0589	response to stress
TspCOW1_33490	COG0659	secondary active sulfate transmembrane transporter activity
TspCOW1_33560	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
TspCOW1_33570	COG2801	Transposase and inactivated derivatives