locus-tag	class	description
TBH_C0001	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
TBH_C0003	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
TBH_C0004	COG0187	DNA topoisomerase II activity
TBH_C0009	COG0752	glycyl-tRNA synthetase alpha subunit
TBH_C0010	COG0439	Biotin carboxylase
TBH_C0011	COG0511	ligase activity, forming carbon-carbon bonds
TBH_C0012	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
TBH_C0013	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
TBH_C0014	COG4232	protein-disulfide reductase activity
TBH_C0015	COG1324	tolerance protein
TBH_C0017	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
TBH_C0027	COG0330	HflC and HflK could
TBH_C0028	COG0037	tRNA processing
TBH_C0030	COG1368	sulfuric ester hydrolase activity
TBH_C0032	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
TBH_C0033	COG3909	cytochrome
TBH_C0036	COG2813	Specifically methylates the guanine in position
TBH_C0037	COG2081	HI0933 family
TBH_C0038	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
TBH_C0039	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
TBH_C0040	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
TBH_C0045	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
TBH_C0047	COG0018	arginyl-trna synthetase
TBH_C0052	COG0546	phosphoglycolate phosphatase activity
TBH_C0055	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
TBH_C0056	COG0134	indole-3-glycerol-phosphate synthase activity
TBH_C0058	COG1765	OsmC-like protein
TBH_C0060	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
TBH_C0061	COG2967	ApaG domain
TBH_C0063	COG4206	TonB-dependent receptor
TBH_C0065	COG0811	peptide transport
TBH_C0066	COG0811	peptide transport
TBH_C0067	COG0848	biopolymer transport protein
TBH_C0070	COG2755	lipolytic protein G-D-S-L family
TBH_C0070	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
TBH_C0075	COG0151	Belongs to the GarS family
TBH_C0076	COG0138	bifunctional purine biosynthesis protein purh
TBH_C0077	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
TBH_C0080	COG2264	protein methyltransferase activity
TBH_C0081	COG3118	belongs to the thioredoxin family
TBH_C0082	COG0181	hydroxymethylbilane synthase activity
TBH_C0084	COG1301	dicarboxylic acid transport
TBH_C0088	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
TBH_C0088	COG0678	peroxiredoxin activity
TBH_C0089	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
TBH_C0091	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
TBH_C0098	COG0745	RESPONSE REGULATOR receiver
TBH_C0098	COG3706	GGDEF domain
TBH_C0099	COG0315	cyclic pyranopterin monophosphate synthase activity
TBH_C0101	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
TBH_C0102	COG0450	alkyl hydroperoxide reductase
TBH_C0104	COG0205	6-phosphofructokinase activity
TBH_C0112	COG2192	nodulation
TBH_C0113	COG1088	dTDP-glucose 4,6-dehydratase activity
TBH_C0117	COG1560	Kdo2-lipid A biosynthetic process
TBH_C0118	COG1132	(ABC) transporter
TBH_C0122	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
TBH_C0122	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
TBH_C0124	COG0667	Aldo Keto reductase
TBH_C0125	COG1519	Transferase
TBH_C0126	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
TBH_C0127	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
TBH_C0129	COG0521	Mo-molybdopterin cofactor biosynthetic process
TBH_C0131	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
TBH_C0132	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
TBH_C0133	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
TBH_C0135	COG0404	The glycine cleavage system catalyzes the degradation of glycine
TBH_C0136	COG3706	GGDEF domain
TBH_C0137	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
TBH_C0138	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
TBH_C0139	COG0006	proline dipeptidase activity
TBH_C0140	COG3079	Belongs to the UPF0149 family
TBH_C0143	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
TBH_C0145	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
TBH_C0146	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
TBH_C0149	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
TBH_C0150	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
TBH_C0153	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
TBH_C0154	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
TBH_C0155	COG0635	Involved in the biosynthesis of porphyrin-containing compound
TBH_C0157	COG0254	rRNA binding
TBH_C0158	COG0281	malic enzyme
TBH_C0159	COG0039	L-malate dehydrogenase activity
TBH_C0167	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
TBH_C0168	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
TBH_C0169	COG0067	glutamate synthase
TBH_C0169	COG0070	glutamate synthase
TBH_C0169	COG0069	glutamate synthase activity
TBH_C0174	COG0312	modulator of DNA gyrase
TBH_C0175	COG0312	modulator of DNA gyrase
TBH_C0180	COG0697	spore germination
TBH_C0182	COG0312	modulator of DNA gyrase
TBH_C0183	COG0312	modulator of DNA gyrase
TBH_C0184	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
TBH_C0186	COG1530	ribonuclease E activity
TBH_C0187	COG0424	maF-like protein
TBH_C0188	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
TBH_C0189	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
TBH_C0190	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
TBH_C0190	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
TBH_C0192	COG0450	alkyl hydroperoxide reductase
TBH_C0194	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
TBH_C0200	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
TBH_C0201	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
TBH_C0202	COG0163	prenyltransferase activity
TBH_C0203	COG2197	response regulator
TBH_C0204	COG0586	Pfam SNARE associated Golgi protein
TBH_C0205	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
TBH_C0206	COG0352	thiamine-phosphate diphosphorylase activity
TBH_C0216	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
TBH_C0217	COG0357	Ribosomal RNA small subunit methyltransferase G
TBH_C0219	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
TBH_C0220	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
TBH_C0221	COG1192	Involved in chromosome partitioning
TBH_C0222	COG1475	DNA binding
TBH_C0224	COG0356	it plays a direct role in the translocation of protons across the membrane
TBH_C0226	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
TBH_C0227	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
TBH_C0228	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
TBH_C0229	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
TBH_C0230	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
TBH_C0231	COG0355	proton-transporting ATP synthase activity, rotational mechanism
TBH_C0232	COG1047	Peptidyl-prolyl cis-trans
TBH_C0233	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
TBH_C0234	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
TBH_C0240	COG0133	tryptophan synthase activity
TBH_C0244	COG1011	Hydrolase
TBH_C0246	COG0513	Belongs to the DEAD box helicase family
TBH_C0248	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
TBH_C0249	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
TBH_C0252	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
TBH_C0254	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
TBH_C0255	COG0321	lipoyl(octanoyl) transferase activity
TBH_C0258	COG1686	Belongs to the peptidase S11 family
TBH_C0259	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
TBH_C0260	COG2951	lytic endotransglycosylase activity
TBH_C0261	COG0772	Belongs to the SEDS family
TBH_C0262	COG0768	penicillin binding
TBH_C0263	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
TBH_C0264	COG1792	Involved in formation and maintenance of cell shape
TBH_C0265	COG1077	Cell shape determining protein MreB Mrl
TBH_C0266	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
TBH_C0267	COG0154	amidase activity
TBH_C0268	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
TBH_C0269	COG4106	trans-aconitate 2-methyltransferase activity
TBH_C0272	COG2813	Specifically methylates the guanine in position
TBH_C0273	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
TBH_C0274	COG2890	protein-(glutamine-N5) methyltransferase activity
TBH_C0275	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
TBH_C0276	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
TBH_C0280	COG2409	Drug exporters of the RND superfamily
TBH_C0281	COG0193	aminoacyl-tRNA hydrolase activity
TBH_C0282	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
TBH_C0283	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
TBH_C0284	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
TBH_C0286	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
TBH_C0287	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
TBH_C0289	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
TBH_C0290	COG0081	regulation of translation
TBH_C0291	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
TBH_C0292	COG0222	ribosome binding
TBH_C0293	COG0085	RNA polymerase activity
TBH_C0294	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
TBH_C0295	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
TBH_C0296	COG0049	tRNA binding
TBH_C0297	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
TBH_C0298	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
TBH_C0299	COG0051	transcription antitermination factor activity, RNA binding
TBH_C0300	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
TBH_C0302	COG0089	rRNA binding
TBH_C0303	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
TBH_C0304	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
TBH_C0305	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
TBH_C0306	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
TBH_C0307	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
TBH_C0308	COG0255	Belongs to the universal ribosomal protein uL29 family
TBH_C0309	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
TBH_C0310	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
TBH_C0311	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
TBH_C0312	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
TBH_C0313	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
TBH_C0314	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
TBH_C0315	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
TBH_C0316	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
TBH_C0317	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
TBH_C0318	COG1841	ribosomal large subunit assembly
TBH_C0319	COG0200	Binds to the 23S rRNA
TBH_C0320	COG0201	protein transport
TBH_C0321	COG0257	Belongs to the bacterial ribosomal protein bL36 family
TBH_C0322	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
TBH_C0323	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
TBH_C0324	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
TBH_C0325	COG0202	RNA polymerase activity
TBH_C0326	COG0203	ribosomal protein L17
TBH_C0329	COG3852	Histidine kinase
TBH_C0330	COG2204	response regulator
TBH_C0332	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
TBH_C0332	COG0426	domain, Protein
TBH_C0334	COG0167	dihydroorotate dehydrogenase activity
TBH_C0335	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
TBH_C0336	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
TBH_C0337	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
TBH_C0338	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
TBH_C0339	COG0640	Transcriptional regulator
TBH_C0340	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
TBH_C0341	COG4942	peptidase
TBH_C0342	COG0793	Belongs to the peptidase S41A family
TBH_C0343	COG0693	protein deglycase activity
TBH_C0345	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
TBH_C0350	COG4585	Histidine kinase
TBH_C0351	COG2197	response regulator
TBH_C0353	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
TBH_C0354	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
TBH_C0357	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
TBH_C0357	COG1328	CTP reductase activity
TBH_C0358	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
TBH_C0360	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
TBH_C0361	COG4106	trans-aconitate 2-methyltransferase activity
TBH_C0362	COG0019	diaminopimelate decarboxylase activity
TBH_C0363	COG0400	carboxylic ester hydrolase activity
TBH_C0369	COG1592	Rubrerythrin
TBH_C0370	COG0564	pseudouridine synthase activity
TBH_C0373	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
TBH_C0374	COG1108	ABC-type Mn2 Zn2 transport systems permease components
TBH_C0382	COG0837	glucose binding
TBH_C0383	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
TBH_C0388	COG0629	single-stranded DNA binding
TBH_C0389	COG2814	Major facilitator Superfamily
TBH_C0391	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
TBH_C0392	COG2321	neutral zinc metallopeptidase
TBH_C0393	COG0433	COG0433 Predicted ATPase
TBH_C0394	COG0596	Alpha beta hydrolase
TBH_C0395	COG1490	D-aminoacyl-tRNA deacylase activity
TBH_C0400	COG2094	Belongs to the DNA glycosylase MPG family
TBH_C0401	COG0408	coproporphyrinogen oxidase activity
TBH_C0402	COG0009	L-threonylcarbamoyladenylate synthase
TBH_C0404	COG2922	Belongs to the Smg family
TBH_C0405	COG0758	DNA mediated transformation
TBH_C0406	COG1652	LysM domain
TBH_C0407	COG0242	peptide deformylase activity
TBH_C0408	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
TBH_C0411	COG5000	phosphorelay sensor kinase activity
TBH_C0412	COG2204	response regulator
TBH_C0413	COG0569	domain protein
TBH_C0414	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
TBH_C0416	COG1666	GTP binding
TBH_C0419	COG2363	Small membrane protein
TBH_C0425	COG3706	GGDEF domain
TBH_C0425	COG0745	RESPONSE REGULATOR receiver
TBH_C0426	COG2239	Acts as a magnesium transporter
TBH_C0427	COG0741	lytic transglycosylase activity
TBH_C0427	COG0739	heme binding
TBH_C0427	COG1196	nuclear chromosome segregation
TBH_C0428	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
TBH_C0429	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
TBH_C0431	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
TBH_C0435	COG1137	ATPase activity
TBH_C0436	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
TBH_C0438	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
TBH_C0441	COG1127	ABC transporter
TBH_C0442	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
TBH_C0443	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
TBH_C0444	COG2854	intermembrane phospholipid transfer
TBH_C0446	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
TBH_C0447	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
TBH_C0448	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
TBH_C0449	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
TBH_C0451	COG3647	Membrane
TBH_C0452	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
TBH_C0453	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
TBH_C0454	COG0723	plastoquinol--plastocyanin reductase activity
TBH_C0455	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
TBH_C0456	COG2857	Cytochrome c1
TBH_C0457	COG0625	glutathione transferase activity
TBH_C0458	COG2969	positive regulation of protein catabolic process
TBH_C0461	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
TBH_C0463	COG0390	transport system, permease component
TBH_C0465	COG2920	part of a sulfur-relay system
TBH_C0466	COG0220	tRNA (guanine-N7-)-methyltransferase activity
TBH_C0467	COG2022	thiamine diphosphate biosynthetic process
TBH_C0469	COG1022	Amp-dependent synthetase and ligase
TBH_C0470	COG0004	ammonium transporteR
TBH_C0471	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
TBH_C0473	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
TBH_C0474	COG1459	type II secretion system
TBH_C0475	COG2165	general secretion pathway protein
TBH_C0476	COG4970	Tfp pilus assembly protein FimT
TBH_C0477	COG2165	general secretion pathway protein
TBH_C0479	COG3156	type II secretion system protein K
TBH_C0483	COG1450	Type ii and iii secretion system protein
TBH_C0487	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
TBH_C0496	COG2755	lipolytic protein G-D-S-L family
TBH_C0496	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
TBH_C0499	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
TBH_C0503	COG2863	cytochrome
TBH_C0504	COG0210	DNA helicase
TBH_C0505	COG1611	Belongs to the LOG family
TBH_C0508	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
TBH_C0509	COG3005	denitrification pathway
TBH_C0513	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
TBH_C0514	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
TBH_C0519	COG4133	protoheme IX ABC transporter activity
TBH_C0521	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
TBH_C0523	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
TBH_C0525	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
TBH_C0529	COG0651	ATP synthesis coupled electron transport
TBH_C0530	COG0650	Formate hydrogenlyase subunit 4
TBH_C0532	COG0651	ATP synthesis coupled electron transport
TBH_C0533	COG3261	NADH dehydrogenase
TBH_C0533	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
TBH_C0534	COG3260	NADH ubiquinone oxidoreductase 20
TBH_C0535	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
TBH_C0536	COG3104	oligopeptide transport
TBH_C0538	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
TBH_C0539	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
TBH_C0540	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
TBH_C0541	COG3954	Phosphoribulokinase
TBH_C0544	COG0277	FAD linked oxidase domain protein
TBH_C0545	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
TBH_C0546	COG0792	nuclease activity
TBH_C0547	COG3107	peptidoglycan biosynthetic process
TBH_C0548	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
TBH_C0549	COG2001	Belongs to the MraZ family
TBH_C0550	COG0275	rRNA processing
TBH_C0551	COG3116	cell division
TBH_C0553	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
TBH_C0554	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
TBH_C0555	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
TBH_C0556	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
TBH_C0557	COG0772	Belongs to the SEDS family
TBH_C0558	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
TBH_C0559	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
TBH_C0560	COG0812	UDP-N-acetylmuramate dehydrogenase activity
TBH_C0561	COG1181	Belongs to the D-alanine--D-alanine ligase family
TBH_C0564	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
TBH_C0565	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
TBH_C0567	COG0739	heme binding
TBH_C0568	COG0653	protein targeting
TBH_C0569	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
TBH_C0570	COG0494	nUDIX hydrolase
TBH_C0572	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
TBH_C0580	COG0367	asparagine synthase
TBH_C0581	COG0297	glycogen (starch) synthase activity
TBH_C0583	COG2226	methyltransferase
TBH_C0584	COG0438	transferase activity, transferring glycosyl groups
TBH_C0587	COG4969	Belongs to the N-Me-Phe pilin family
TBH_C0601	COG2801	Transposase and inactivated derivatives
TBH_C0606	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
TBH_C0607	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
TBH_C0607	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
TBH_C0609	COG1752	Esterase of the alpha-beta hydrolase superfamily
TBH_C0614	COG5002	protein histidine kinase activity
TBH_C0614	COG5001	Diguanylate cyclase
TBH_C0615	COG1763	Mo-molybdopterin cofactor biosynthetic process
TBH_C0616	COG0318	PFAM AMP-dependent synthetase and ligase
TBH_C0618	COG1441	menaquinone biosynthetic process
TBH_C0619	COG4263	nitrous-oxide reductase activity
TBH_C0625	COG0437	4 iron, 4 sulfur cluster binding
TBH_C0626	COG0348	domain, Protein
TBH_C0631	COG1169	isochorismate synthase
TBH_C0632	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
TBH_C0633	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
TBH_C0634	COG1575	Belongs to the MenA family. Type 1 subfamily
TBH_C0635	COG0616	signal peptide processing
TBH_C0637	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
TBH_C0638	COG3422	double-strand break repair
TBH_C0641	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
TBH_C0642	COG1940	carbohydrate kinase activity
TBH_C0647	COG1192	Involved in chromosome partitioning
TBH_C0652	COG3547	Transposase (IS116 IS110 IS902 family)
TBH_C0653	COG1509	lysine 2,3-aminomutase activity
TBH_C0654	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
TBH_C0656	COG0688	phosphatidylethanolamine metabolic process
TBH_C0658	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
TBH_C0659	COG0343	queuine tRNA-ribosyltransferase activity
TBH_C0661	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
TBH_C0661	COG1796	DNA polymerase
TBH_C0663	COG0494	nUDIX hydrolase
TBH_C0665	COG1570	exodeoxyribonuclease VII activity
TBH_C0667	COG0518	GMP synthase (glutamine-hydrolyzing) activity
TBH_C0667	COG0519	Catalyzes the synthesis of GMP from XMP
TBH_C0670	COG0129	dihydroxy-acid dehydratase activity
TBH_C0673	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
TBH_C0674	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
TBH_C0680	COG0367	asparagine synthase
TBH_C0683	COG0745	RESPONSE REGULATOR receiver
TBH_C0685	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
TBH_C0686	COG0534	Mate efflux family protein
TBH_C0691	COG0243	molybdopterin cofactor binding
TBH_C0692	COG0437	4 iron, 4 sulfur cluster binding
TBH_C0693	COG3302	dmso reductase anchor subunit
TBH_C0695	COG0588	phosphoglycerate mutase activity
TBH_C0699	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
TBH_C0699	COG0574	Belongs to the PEP-utilizing enzyme family
TBH_C0702	COG0432	Pfam Uncharacterised protein family UPF0047
TBH_C0707	COG0515	serine threonine protein kinase
TBH_C0707	COG2815	serine threonine protein kinase
TBH_C0708	COG0131	Imidazoleglycerol-phosphate dehydratase
TBH_C0709	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
TBH_C0710	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
TBH_C0711	COG0107	imidazoleglycerol-phosphate synthase activity
TBH_C0712	COG0140	phosphoribosyl-ATP diphosphatase activity
TBH_C0713	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
TBH_C0714	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
TBH_C0716	COG1331	Highly conserved protein containing a thioredoxin domain
TBH_C0718	COG0544	peptidyl-prolyl cis-trans isomerase activity
TBH_C0719	COG0740	serine-type endopeptidase activity
TBH_C0720	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
TBH_C0721	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
TBH_C0722	COG0776	regulation of translation
TBH_C0723	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
TBH_C0724	COG3547	Transposase (IS116 IS110 IS902 family)
TBH_C0726	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
TBH_C0727	COG4464	protein tyrosine phosphatase activity
TBH_C0729	COG0489	protein tyrosine kinase activity
TBH_C0730	COG0484	heat shock protein binding
TBH_C0736	COG1132	(ABC) transporter
TBH_C0737	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
TBH_C0738	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
TBH_C0740	COG2089	acid synthase
TBH_C0741	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
TBH_C0742	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
TBH_C0743	COG1083	cytidylyl-transferase
TBH_C0747	COG0463	Glycosyl transferase, family 2
TBH_C0747	COG1216	Glycosyl transferase, family 2
TBH_C0754	COG3436	PFAM IS66 Orf2 family protein
TBH_C0755	COG4372	Transposase
TBH_C0757	COG0297	glycogen (starch) synthase activity
TBH_C0759	COG1434	Gram-negative-bacterium-type cell wall biogenesis
TBH_C0766	COG0535	radical SAM domain protein
TBH_C0768	COG4608	Belongs to the ABC transporter superfamily
TBH_C0770	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
TBH_C0771	COG0601	transmembrane transport
TBH_C0772	COG0339	signal peptide processing
TBH_C0773	COG4166	transmembrane transport
TBH_C0774	COG1388	LysM domain
TBH_C0774	COG0741	lytic transglycosylase activity
TBH_C0777	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
TBH_C0780	COG1858	cytochrome C peroxidase
TBH_C0784	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
TBH_C0786	COG0563	adenylate kinase activity
TBH_C0791	COG0587	DNA-directed DNA polymerase activity
TBH_C0797	COG1120	ATPase activity
TBH_C0798	COG4139	cobalamin transport
TBH_C0801	COG3547	Transposase (IS116 IS110 IS902 family)
TBH_C0802	COG0494	nUDIX hydrolase
TBH_C0803	COG0069	glutamate synthase activity
TBH_C0804	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
TBH_C0804	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
TBH_C0804	COG1013	pyruvate-flavodoxin oxidoreductase activity
TBH_C0804	COG0674	pyruvate-flavodoxin oxidoreductase activity
TBH_C0805	COG0167	dihydroorotate dehydrogenase activity
TBH_C0806	COG0210	DNA helicase
TBH_C0808	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
TBH_C0811	COG2801	Transposase and inactivated derivatives
TBH_C0817	COG1528	Iron-storage protein
TBH_C0820	COG0672	)-iron permease
TBH_C0825	COG1272	protein, Hemolysin III
TBH_C0833	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
TBH_C0835	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
TBH_C0836	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
TBH_C0837	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
TBH_C0837	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
TBH_C0841	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
TBH_C0842	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
TBH_C0844	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
TBH_C0848	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
TBH_C0849	COG0668	transmembrane transport
TBH_C0851	COG0681	Belongs to the peptidase S26 family
TBH_C0856	COG1968	undecaprenyl-diphosphatase activity
TBH_C0858	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
TBH_C0859	COG3028	Belongs to the UPF0307 family
TBH_C0862	COG1053	succinate dehydrogenase
TBH_C0863	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
TBH_C0864	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
TBH_C0866	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
TBH_C0868	COG1404	Belongs to the peptidase S8 family
TBH_C0869	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
TBH_C0870	COG2197	response regulator
TBH_C0871	COG1573	uracil-dna glycosylase
TBH_C0872	COG0733	neurotransmitter:sodium symporter activity
TBH_C0873	COG0322	excinuclease ABC activity
TBH_C0877	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
TBH_C0878	COG1131	(ABC) transporter
TBH_C0881	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
TBH_C0882	COG1127	ABC transporter
TBH_C0885	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
TBH_C0888	COG4657	Part of a membrane complex involved in electron transport
TBH_C0889	COG4660	Part of a membrane complex involved in electron transport
TBH_C0890	COG4659	FMN binding
TBH_C0891	COG4658	electron transport chain
TBH_C0892	COG4656	Part of a membrane complex involved in electron transport
TBH_C0895	COG1148	4fe-4S ferredoxin, iron-sulfur binding domain protein
TBH_C0895	COG2878	Part of a membrane complex involved in electron transport
TBH_C0896	COG0583	DNA-binding transcription factor activity
TBH_C0898	COG0243	molybdopterin cofactor binding
TBH_C0921	COG2267	carboxylic ester hydrolase activity
TBH_C0922	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
TBH_C0923	COG1028	Short-chain dehydrogenase reductase Sdr
TBH_C0925	COG3384	dioxygenase
TBH_C0926	COG1802	Transcriptional regulator
TBH_C0929	COG4569	acetaldehyde dehydrogenase (acetylating) activity
TBH_C0937	COG1028	Short-chain dehydrogenase reductase Sdr
TBH_C0938	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
TBH_C0940	COG0277	FAD linked oxidase domain protein
TBH_C0959	COG2135	peptidase activity
TBH_C0972	COG0629	single-stranded DNA binding
TBH_C0975	COG0142	geranyltranstransferase activity
TBH_C0976	COG0261	This protein binds to 23S rRNA in the presence of protein L20
TBH_C0977	COG0211	Belongs to the bacterial ribosomal protein bL27 family
TBH_C0978	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
TBH_C0979	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
TBH_C0980	COG0730	response to heat
TBH_C0985	COG0741	lytic transglycosylase activity
TBH_C0987	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
TBH_C0988	COG4608	Belongs to the ABC transporter superfamily
TBH_C0989	COG0444	Belongs to the ABC transporter superfamily
TBH_C0990	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
TBH_C0992	COG0747	negative chemotaxis
TBH_C0993	COG0613	PHP domain protein
TBH_C0994	COG0009	L-threonylcarbamoyladenylate synthase
TBH_C0995	COG1994	Peptidase M50
TBH_C0996	COG0180	Tryptophanyl-tRNA synthetase
TBH_C0998	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
TBH_C1002	COG0729	surface antigen
TBH_C1004	COG1160	GTP binding
TBH_C1006	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
TBH_C1011	COG1842	Phage shock protein A
TBH_C1013	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
TBH_C1015	COG0227	Belongs to the bacterial ribosomal protein bL28 family
TBH_C1017	COG2003	Belongs to the UPF0758 family
TBH_C1018	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
TBH_C1020	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
TBH_C1024	COG0045	succinate-CoA ligase (ADP-forming) activity
TBH_C1025	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
TBH_C1026	COG0268	Binds directly to 16S ribosomal RNA
TBH_C1028	COG0728	peptidoglycan biosynthetic process
TBH_C1030	COG0196	riboflavin kinase activity
TBH_C1031	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
TBH_C1032	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
TBH_C1033	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
TBH_C1039	COG0545	Peptidyl-prolyl cis-trans isomerase
TBH_C1041	COG0564	pseudouridine synthase activity
TBH_C1043	COG3706	GGDEF domain
TBH_C1045	COG0242	peptide deformylase activity
TBH_C1047	COG0542	response to heat
TBH_C1052	COG1024	Enoyl-CoA hydratase
TBH_C1053	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
TBH_C1054	COG0508	dehydrogenase complex catalyzes the overall conversion of
TBH_C1055	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
TBH_C1057	COG0596	Alpha beta hydrolase
TBH_C1058	COG0708	Exodeoxyribonuclease III
TBH_C1059	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
TBH_C1061	COG0517	IMP dehydrogenase activity
TBH_C1063	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
TBH_C1065	COG2204	response regulator
TBH_C1066	COG3852	Histidine kinase
TBH_C1071	COG0446	pyridine nucleotide-disulphide oxidoreductase
TBH_C1073	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
TBH_C1075	COG1012	belongs to the aldehyde dehydrogenase family
TBH_C1077	COG1047	Peptidyl-prolyl cis-trans
TBH_C1079	COG2096	Adenosyltransferase
TBH_C1080	COG4206	TonB-dependent receptor
TBH_C1082	COG1959	2 iron, 2 sulfur cluster binding
TBH_C1083	COG1104	cysteine desulfurase activity
TBH_C1084	COG0822	iron-sulfur transferase activity
TBH_C1085	COG0316	Belongs to the HesB IscA family
TBH_C1086	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
TBH_C1093	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
TBH_C1095	COG3547	Transposase (IS116 IS110 IS902 family)
TBH_C1096	COG1131	(ABC) transporter
TBH_C1097	COG0842	Transport permease protein
TBH_C1098	COG2270	Major facilitator Superfamily
TBH_C1103	COG0306	phosphate transporter
TBH_C1106	COG1566	PFAM secretion protein HlyD family protein
TBH_C1108	COG0628	permease
TBH_C1116	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
TBH_C1119	COG1028	Short-chain dehydrogenase reductase Sdr
TBH_C1125	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
TBH_C1126	COG0481	GTPase activity
TBH_C1130	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
TBH_C1131	COG1381	Involved in DNA repair and RecF pathway recombination
TBH_C1132	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
TBH_C1135	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
TBH_C1138	COG1472	Belongs to the glycosyl hydrolase 3 family
TBH_C1143	COG3693	PFAM glycoside hydrolase, family 10
TBH_C1149	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
TBH_C1150	COG0024	Methionine aminopeptidase
TBH_C1151	COG0052	Belongs to the universal ribosomal protein uS2 family
TBH_C1152	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
TBH_C1153	COG0528	UMP kinase activity
TBH_C1154	COG0233	cytoplasmic translational termination
TBH_C1155	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
TBH_C1156	COG0575	Belongs to the CDS family
TBH_C1157	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
TBH_C1162	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
TBH_C1164	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
TBH_C1165	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
TBH_C1167	COG0825	malonyl-CoA metabolic process
TBH_C1168	COG0037	tRNA processing
TBH_C1169	COG2995	paraquat-inducible protein a
TBH_C1172	COG0784	Response regulator, receiver
TBH_C1172	COG2205	protein histidine kinase activity
TBH_C1172	COG5002	protein histidine kinase activity
TBH_C1177	COG4771	TonB-dependent receptor
TBH_C1180	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
TBH_C1182	COG0557	exoribonuclease II activity
TBH_C1185	COG1070	Carbohydrate kinase
TBH_C1188	COG2015	COG2015, Alkyl sulfatase and related hydrolases
TBH_C1190	COG2199	diguanylate cyclase activity
TBH_C1192	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
TBH_C1195	COG1469	GTP cyclohydrolase I activity
TBH_C1196	COG0142	geranyltranstransferase activity
TBH_C1199	COG0187	DNA topoisomerase II activity
TBH_C1203	COG1862	Preprotein translocase
TBH_C1204	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
TBH_C1205	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
TBH_C1211	COG0714	Associated with various cellular activities
TBH_C1212	COG0149	triose-phosphate isomerase activity
TBH_C1214	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
TBH_C1215	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
TBH_C1216	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
TBH_C1217	COG0649	NAD binding
TBH_C1220	COG1034	ATP synthesis coupled electron transport
TBH_C1221	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
TBH_C1222	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
TBH_C1224	COG0713	ATP synthesis coupled electron transport
TBH_C1227	COG1007	ATP synthesis coupled electron transport
TBH_C1231	COG0745	RESPONSE REGULATOR receiver
TBH_C1232	COG2205	protein histidine kinase activity
TBH_C1235	COG2166	iron-sulfur cluster assembly
TBH_C1236	COG0316	Belongs to the HesB IscA family
TBH_C1237	COG2151	metal-sulfur cluster biosynthetic enzyme
TBH_C1238	COG0719	Fe-S assembly protein
TBH_C1239	COG0396	ATPase activity
TBH_C1240	COG0719	Fe-S assembly protein
TBH_C1245	COG1234	tRNA 3'-trailer cleavage
TBH_C1251	COG2304	oxidoreductase activity
TBH_C1252	COG3764	Sortase (surface protein transpeptidase)
TBH_C1256	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
TBH_C1260	COG0525	valine-tRNA ligase activity
TBH_C1264	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
TBH_C1265	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
TBH_C1266	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
TBH_C1270	COG0789	Transcriptional regulator
TBH_C1273	COG0418	dihydroorotase activity
TBH_C1277	COG3273	potassium ion transport
TBH_C1277	COG0471	metal ion transport
TBH_C1278	COG0742	ribosomal rna small subunit methyltransferase
TBH_C1280	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
TBH_C1281	COG4783	chaperone-mediated protein folding
TBH_C1282	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
TBH_C1283	COG0066	3-isopropylmalate dehydratase activity
TBH_C1284	COG1247	-acetyltransferase
TBH_C1285	COG0473	3-isopropylmalate dehydrogenase activity
TBH_C1289	COG0135	phosphoribosylanthranilate isomerase activity
TBH_C1290	COG0133	tryptophan synthase activity
TBH_C1291	COG0159	tryptophan synthase activity
TBH_C1292	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
TBH_C1293	COG0285	dihydrofolate synthase activity
TBH_C1295	COG1286	toxin biosynthetic process
TBH_C1301	COG3228	Belongs to the MtfA family
TBH_C1302	COG1674	ftsk spoiiie
TBH_C1303	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
TBH_C1304	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
TBH_C1305	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
TBH_C1307	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
TBH_C1311	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
TBH_C1313	COG0291	Belongs to the bacterial ribosomal protein bL35 family
TBH_C1314	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
TBH_C1315	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
TBH_C1316	COG0072	phenylalanine-tRNA ligase activity
TBH_C1317	COG0776	regulation of translation
TBH_C1325	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
TBH_C1328	COG2379	hydroxypyruvate reductase
TBH_C1329	COG2833	Protein of unknown function (DUF455)
TBH_C1331	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
TBH_C1333	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
TBH_C1334	COG0215	cysteine-tRNA ligase activity
TBH_C1336	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
TBH_C1337	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
TBH_C1341	COG0438	transferase activity, transferring glycosyl groups
TBH_C1348	COG0589	response to stress
TBH_C1350	COG0531	amino acid
TBH_C1351	COG0531	amino acid
TBH_C1354	COG2204	response regulator
TBH_C1356	COG1360	Flagellar Motor Protein
TBH_C1357	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
TBH_C1358	COG5001	Diguanylate cyclase
TBH_C1358	COG4251	negative regulation of phosphorylation
TBH_C1358	COG3706	GGDEF domain
TBH_C1358	COG2203	Gaf domain
TBH_C1363	COG1558	bacterial-type flagellum-dependent cell motility
TBH_C1364	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
TBH_C1365	COG1749	Flagellar hook protein flgE
TBH_C1366	COG4787	bacterial-type flagellum-dependent cell motility
TBH_C1367	COG4786	Flagellar basal body rod
TBH_C1368	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
TBH_C1369	COG1706	bacterial-type flagellum-dependent cell motility
TBH_C1370	COG3951	Flagellar rod assembly protein muramidase FlgJ
TBH_C1370	COG1705	Flagellar rod assembly protein muramidase FlgJ
TBH_C1371	COG1256	bacterial-type flagellum assembly
TBH_C1373	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
TBH_C1374	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
TBH_C1375	COG1334	flagellar protein FlaG
TBH_C1376	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
TBH_C1380	COG3852	Histidine kinase
TBH_C1381	COG2204	response regulator
TBH_C1382	COG1677	Flagellar hook-basal body complex protein FliE
TBH_C1384	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
TBH_C1395	COG1987	bacterial-type flagellum assembly
TBH_C1398	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
TBH_C1400	COG0455	bacterial-type flagellum organization
TBH_C1408	COG0501	Belongs to the peptidase M48B family
TBH_C1409	COG1704	LemA family
TBH_C1411	COG1643	Atp-dependent helicase
TBH_C1415	COG3012	SEC-C Motif Domain Protein
TBH_C1416	COG1196	nuclear chromosome segregation
TBH_C1416	COG0741	lytic transglycosylase activity
TBH_C1416	COG0739	heme binding
TBH_C1421	COG0326	Molecular chaperone. Has ATPase activity
TBH_C1424	COG0563	adenylate kinase activity
TBH_C1425	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
TBH_C1427	COG1959	2 iron, 2 sulfur cluster binding
TBH_C1428	COG1399	metal-binding, possibly nucleic acid-binding protein
TBH_C1429	COG0333	Belongs to the bacterial ribosomal protein bL32 family
TBH_C1430	COG0416	fatty acid biosynthetic process
TBH_C1431	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
TBH_C1432	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
TBH_C1434	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
TBH_C1435	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
TBH_C1436	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
TBH_C1437	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
TBH_C1438	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
TBH_C1441	COG0084	hydrolase, TatD family'
TBH_C1450	COG2204	response regulator
TBH_C1451	COG4191	Histidine kinase
TBH_C1452	COG0672	)-iron permease
TBH_C1459	COG2217	Heavy metal translocating P-type atpase
TBH_C1473	COG4251	negative regulation of phosphorylation
TBH_C1473	COG3706	GGDEF domain
TBH_C1473	COG5001	Diguanylate cyclase
TBH_C1473	COG2203	Gaf domain
TBH_C1474	COG2201	protein-glutamate methylesterase activity
TBH_C1477	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
TBH_C1479	COG0840	transmembrane signaling receptor activity
TBH_C1481	COG4106	trans-aconitate 2-methyltransferase activity
TBH_C1485	COG0556	nucleotide-excision repair
TBH_C1492	COG0668	transmembrane transport
TBH_C1493	COG2850	peptidyl-arginine hydroxylation
TBH_C1496	COG2046	Belongs to the sulfate adenylyltransferase family
TBH_C1498	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
TBH_C1499	COG1518	maintenance of DNA repeat elements
TBH_C1504	COG1857	crispr-associated protein
TBH_C1507	COG1203	CRISPR-associated helicase, Cas3
TBH_C1508	COG0284	orotidine-5'-phosphate decarboxylase activity
TBH_C1509	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
TBH_C1511	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
TBH_C1512	COG0484	heat shock protein binding
TBH_C1513	COG0443	Heat shock 70 kDa protein
TBH_C1514	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
TBH_C1515	COG1420	regulation of RNA biosynthetic process
TBH_C1516	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
TBH_C1517	COG0497	DNA recombination
TBH_C1518	COG0735	belongs to the Fur family
TBH_C1519	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
TBH_C1520	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
TBH_C1521	COG0501	Belongs to the peptidase M48B family
TBH_C1523	COG1162	GTPase activity
TBH_C1526	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
TBH_C1527	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
TBH_C1528	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
TBH_C1530	COG0795	lipopolysaccharide-transporting ATPase activity
TBH_C1531	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
TBH_C1533	COG3437	response regulator, receiver
TBH_C1534	COG3850	Histidine kinase
TBH_C1534	COG4999	Histidine kinase
TBH_C1534	COG2205	protein histidine kinase activity
TBH_C1534	COG3437	response regulator, receiver
TBH_C1535	COG1185	polyribonucleotide nucleotidyltransferase activity
TBH_C1536	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
TBH_C1537	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
TBH_C1538	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
TBH_C1539	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
TBH_C1540	COG0195	Participates in both transcription termination and antitermination
TBH_C1540	COG2251	uridine kinase activity
TBH_C1541	COG0779	Required for maturation of 30S ribosomal subunits
TBH_C1543	COG2867	negative regulation of translational initiation
TBH_C1544	COG1115	amino acid carrier protein
TBH_C1545	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
TBH_C1546	COG2326	polyphosphate kinase activity
TBH_C1549	COG0546	phosphoglycolate phosphatase activity
TBH_C1552	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
TBH_C1553	COG2217	Heavy metal translocating P-type atpase
TBH_C1557	COG2132	Multicopper oxidase
TBH_C1564	COG0243	molybdopterin cofactor binding
TBH_C1565	COG0437	4 iron, 4 sulfur cluster binding
TBH_C1571	COG2835	tetraacyldisaccharide 4'-kinase activity
TBH_C1572	COG0848	biopolymer transport protein
TBH_C1573	COG0811	peptide transport
TBH_C1576	COG1136	(ABC) transporter
TBH_C1577	COG4591	ABC-type transport system involved in lipoprotein release permease component
TBH_C1583	COG0745	RESPONSE REGULATOR receiver
TBH_C1583	COG3706	GGDEF domain
TBH_C1588	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
TBH_C1594	COG0745	RESPONSE REGULATOR receiver
TBH_C1595	COG5002	protein histidine kinase activity
TBH_C1598	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
TBH_C1599	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
TBH_C1602	COG0517	IMP dehydrogenase activity
TBH_C1603	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
TBH_C1604	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
TBH_C1607	COG1214	PFAM Peptidase M22, glycoprotease
TBH_C1609	COG0567	Dehydrogenase, E1 component
TBH_C1610	COG0508	dehydrogenase complex catalyzes the overall conversion of
TBH_C1617	COG0398	Pfam SNARE associated Golgi protein
TBH_C1629	COG0436	Aminotransferase
TBH_C1630	COG2171	N-acyltransferase activity
TBH_C1631	COG1393	Belongs to the ArsC family
TBH_C1633	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
TBH_C1635	COG0537	adenosine 5'-monophosphoramidase activity
TBH_C1636	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
TBH_C1637	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
TBH_C1639	COG2203	Gaf domain
TBH_C1639	COG2199	diguanylate cyclase activity
TBH_C1640	COG1752	Esterase of the alpha-beta hydrolase superfamily
TBH_C1641	COG0511	ligase activity, forming carbon-carbon bonds
TBH_C1641	COG5016	pyruvate
TBH_C1642	COG0439	Biotin carboxylase
TBH_C1643	COG2862	Uncharacterized protein family, UPF0114
TBH_C1648	COG1309	transcriptional regulator
TBH_C1651	COG1850	ribulose-bisphosphate carboxylase activity
TBH_C1652	COG0583	DNA-binding transcription factor activity
TBH_C1653	COG0084	hydrolase, TatD family'
TBH_C1655	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
TBH_C1656	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
TBH_C1657	COG0148	phosphopyruvate hydratase activity
TBH_C1658	COG2877	3-deoxy-8-phosphooctulonate synthase activity
TBH_C1659	COG0504	CTP synthase activity
TBH_C1661	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
TBH_C1662	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
TBH_C1663	COG3278	Belongs to the heme-copper respiratory oxidase family
TBH_C1666	COG2010	Cytochrome c
TBH_C1669	COG2217	Heavy metal translocating P-type atpase
TBH_C1671	COG0514	ATP-dependent DNA helicase (RecQ)
TBH_C1676	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
TBH_C1677	COG0488	(ABC) transporter
TBH_C1678	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
TBH_C1679	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
TBH_C1683	COG1278	Cold shock
TBH_C1687	COG0482	sulfurtransferase activity
TBH_C1690	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
TBH_C1700	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
TBH_C1701	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
TBH_C1703	COG0668	transmembrane transport
TBH_C1704	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
TBH_C1705	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
TBH_C1706	COG0492	ferredoxin-NADP+ reductase activity
TBH_C1707	COG0686	Belongs to the AlaDH PNT family
TBH_C1708	COG0745	RESPONSE REGULATOR receiver
TBH_C1709	COG0642	Histidine kinase
TBH_C1710	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
TBH_C1711	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
TBH_C1712	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
TBH_C1713	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
TBH_C1715	COG3547	Transposase (IS116 IS110 IS902 family)
TBH_C1717	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
TBH_C1718	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
TBH_C1719	COG0505	Belongs to the CarA family
TBH_C1720	COG3118	belongs to the thioredoxin family
TBH_C1721	COG3118	belongs to the thioredoxin family
TBH_C1722	COG1720	tRNA m6t6A37 methyltransferase activity
TBH_C1727	COG1355	regulation of microtubule-based process
TBH_C1733	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
TBH_C1734	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
TBH_C1735	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
TBH_C1736	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
TBH_C1740	COG2827	Endonuclease containing a URI domain
TBH_C1741	COG0363	glucosamine-6-phosphate deaminase activity
TBH_C1742	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
TBH_C1747	COG0183	Belongs to the thiolase family
TBH_C1749	COG1022	Amp-dependent synthetase and ligase
TBH_C1751	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
TBH_C1752	COG0542	response to heat
TBH_C1753	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
TBH_C1755	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
TBH_C1757	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
TBH_C1761	COG0588	phosphoglycerate mutase activity
TBH_C1762	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
TBH_C1764	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
TBH_C1765	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
TBH_C1767	COG0586	Pfam SNARE associated Golgi protein
TBH_C1768	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
TBH_C1770	COG0508	dehydrogenase complex catalyzes the overall conversion of
TBH_C1777	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
TBH_C1778	COG3588	fructose-bisphosphate aldolase
TBH_C1779	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
TBH_C1780	COG0589	response to stress
TBH_C1785	COG0028	Belongs to the TPP enzyme family
TBH_C1790	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
TBH_C1792	COG0436	Aminotransferase
TBH_C1795	COG1280	lysine exporter protein (LysE YggA)
TBH_C1799	COG4536	flavin adenine dinucleotide binding
TBH_C1806	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
TBH_C1807	COG0305	Participates in initiation and elongation during chromosome replication
TBH_C1808	COG0359	binds to the 23S rRNA
TBH_C1811	COG0360	Binds together with S18 to 16S ribosomal RNA
TBH_C1812	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
TBH_C1813	COG0557	exoribonuclease II activity
TBH_C1815	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
TBH_C1817	COG0463	Glycosyl transferase, family 2
TBH_C1818	COG1881	PFAM PEBP family protein
TBH_C1821	COG0456	acetyltransferase
TBH_C1822	COG1573	uracil-dna glycosylase
TBH_C1823	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
TBH_C1825	COG1183	phosphatidylcholine synthase activity
TBH_C1828	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
TBH_C1830	COG0028	Belongs to the TPP enzyme family
TBH_C1834	COG0745	RESPONSE REGULATOR receiver
TBH_C1842	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
TBH_C1847	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
TBH_C1851	COG1283	sodium-dependent phosphate transmembrane transporter activity
TBH_C1852	COG2925	Exonuclease
TBH_C1854	COG0335	large ribosomal subunit rRNA binding
TBH_C1855	COG0336	Belongs to the RNA methyltransferase TrmD family
TBH_C1856	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
TBH_C1860	COG0076	glutamate decarboxylase activity
TBH_C1863	COG0189	ligase activity
TBH_C1863	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
TBH_C1869	COG2304	oxidoreductase activity
TBH_C1870	COG2304	oxidoreductase activity
TBH_C1873	COG0714	Associated with various cellular activities
TBH_C1874	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
TBH_C1876	COG0248	Ppx GppA phosphatase
TBH_C1877	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
TBH_C1881	COG2917	probably involved in intracellular septation
TBH_C1882	COG2350	Protein conserved in bacteria
TBH_C1887	COG1238	metal cluster binding
TBH_C1889	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
TBH_C1892	COG0585	pseudouridine synthase activity
TBH_C1893	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
TBH_C1894	COG1160	GTP binding
TBH_C1895	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
TBH_C1896	COG2976	Protein conserved in bacteria
TBH_C1897	COG0124	histidyl-tRNA synthetase
TBH_C1900	COG0820	rRNA (adenine-C2-)-methyltransferase activity
TBH_C1901	COG1505	serine-type exopeptidase activity
TBH_C1902	COG1994	Peptidase M50
TBH_C1902	COG0517	IMP dehydrogenase activity
TBH_C1905	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
TBH_C1911	COG1242	4 iron, 4 sulfur cluster binding
TBH_C1915	COG0612	Peptidase, M16
TBH_C1919	COG1149	4fe-4S ferredoxin, iron-sulfur binding domain protein
TBH_C1919	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
TBH_C1921	COG0243	molybdopterin cofactor binding
TBH_C1922	COG0437	4 iron, 4 sulfur cluster binding
TBH_C1923	COG0348	domain, Protein
TBH_C1926	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
TBH_C1926	COG3008	intermembrane lipid transfer
TBH_C1927	COG2995	paraquat-inducible protein a
TBH_C1928	COG2995	paraquat-inducible protein a
TBH_C1932	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
TBH_C1933	COG0302	gtp cyclohydrolase
TBH_C1934	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
TBH_C1936	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
TBH_C1937	COG2137	regulation of response to DNA damage stimulus
TBH_C1940	COG1546	Belongs to the CinA family
TBH_C1943	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
TBH_C1945	COG0631	protein serine/threonine phosphatase activity
TBH_C1946	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
TBH_C1947	COG4974	Belongs to the 'phage' integrase family
TBH_C1948	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
TBH_C1950	COG2983	Belongs to the UPF0260 family
TBH_C1951	COG4681	YaeQ
TBH_C1953	COG1560	Kdo2-lipid A biosynthetic process
TBH_C1957	COG4657	Part of a membrane complex involved in electron transport
TBH_C1958	COG2878	Part of a membrane complex involved in electron transport
TBH_C1960	COG4658	electron transport chain
TBH_C1961	COG4659	FMN binding
TBH_C1962	COG4660	Part of a membrane complex involved in electron transport
TBH_C1963	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
TBH_C1964	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
TBH_C1965	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
TBH_C1966	COG1322	Protein conserved in bacteria
TBH_C1967	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
TBH_C1968	COG1228	amidohydrolase
TBH_C1973	COG0640	Transcriptional regulator
TBH_C1974	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
TBH_C1977	COG0701	Predicted permease
TBH_C1980	COG1524	type I phosphodiesterase nucleotide pyrophosphatase
TBH_C1984	COG2608	mercury ion transmembrane transporter activity
TBH_C1986	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
TBH_C1988	COG1136	(ABC) transporter
TBH_C1995	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
TBH_C1996	COG1230	cation diffusion facilitator family transporter
TBH_C2003	COG4372	Transposase
TBH_C2004	COG3436	PFAM IS66 Orf2 family protein
TBH_C2011	COG2015	COG2015, Alkyl sulfatase and related hydrolases
TBH_C2014	COG0385	Bile acid
TBH_C2016	COG0798	PFAM Bile acid sodium symporter
TBH_C2026	COG0714	Associated with various cellular activities
TBH_C2028	COG1074	ATP-dependent DNA helicase activity
TBH_C2029	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
TBH_C2031	COG0746	molybdenum cofactor guanylyltransferase activity
TBH_C2033	COG0515	serine threonine protein kinase
TBH_C2036	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
TBH_C2037	COG1758	RNA polymerase activity
TBH_C2039	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
TBH_C2040	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
TBH_C2041	COG0742	ribosomal rna small subunit methyltransferase
TBH_C2042	COG0612	Peptidase, M16
TBH_C2043	COG0612	Peptidase, M16
TBH_C2044	COG0552	protein localization to endoplasmic reticulum
TBH_C2045	COG2884	Cell division ATP-binding protein ftsE
TBH_C2046	COG2177	Part of the ABC transporter FtsEX involved in
TBH_C2047	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
TBH_C2048	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
TBH_C2051	COG0156	8-amino-7-oxononanoate synthase activity
TBH_C2052	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
TBH_C2058	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
TBH_C2059	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
TBH_C2060	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
TBH_C2062	COG0828	Belongs to the bacterial ribosomal protein bS21 family
TBH_C2063	COG1610	YqeY-like protein
TBH_C2065	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
TBH_C2082	COG0489	protein tyrosine kinase activity
TBH_C2083	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
TBH_C2083	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
TBH_C2084	COG1199	ATP-dependent helicase activity
TBH_C2088	COG1131	(ABC) transporter
TBH_C2089	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
TBH_C2090	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
TBH_C2091	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
TBH_C2093	COG0330	HflC and HflK could
TBH_C2094	COG0330	HflC and HflK could
TBH_C2095	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
TBH_C2096	COG1923	regulation of RNA biosynthetic process
TBH_C2097	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
TBH_C2098	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
TBH_C2099	COG0446	pyridine nucleotide-disulphide oxidoreductase
TBH_C2100	COG2863	cytochrome
TBH_C2102	COG0860	N-Acetylmuramoyl-L-alanine amidase
TBH_C2103	COG0802	atpase or kinase
TBH_C2104	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
TBH_C2104	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
TBH_C2106	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
TBH_C2107	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
TBH_C2108	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
TBH_C2109	COG2716	regulation of RNA biosynthetic process
TBH_C2110	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
TBH_C2111	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
TBH_C2115	COG0776	regulation of translation
TBH_C2116	COG0539	negative regulation of cytoplasmic translation
TBH_C2117	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
TBH_C2118	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
TBH_C2119	COG0287	Prephenate dehydrogenase
TBH_C2120	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
TBH_C2123	COG0643	Histidine kinase
TBH_C2123	COG2198	Histidine kinase
TBH_C2124	COG0835	chemotaxis
TBH_C2125	COG0840	transmembrane signaling receptor activity
TBH_C2125	COG0840	transmembrane signaling receptor activity
TBH_C2127	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
TBH_C2128	COG2201	protein-glutamate methylesterase activity
TBH_C2131	COG1605	Chorismate mutase
TBH_C2131	COG0077	Prephenate dehydratase
TBH_C2132	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
TBH_C2133	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
TBH_C2135	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
TBH_C2136	COG0402	S-adenosylhomocysteine deaminase activity
TBH_C2137	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
TBH_C2139	COG1028	Short-chain dehydrogenase reductase Sdr
TBH_C2142	COG0617	tRNA 3'-terminal CCA addition
TBH_C2145	COG2010	Cytochrome c
TBH_C2149	COG0714	Associated with various cellular activities
TBH_C2154	COG1643	Atp-dependent helicase
TBH_C2155	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
TBH_C2156	COG0590	tRNA wobble adenosine to inosine editing
TBH_C2159	COG3547	Transposase (IS116 IS110 IS902 family)
TBH_C2164	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
TBH_C2165	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
TBH_C2169	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
TBH_C2175	COG0446	pyridine nucleotide-disulphide oxidoreductase
TBH_C2176	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
TBH_C2181	COG3436	PFAM IS66 Orf2 family protein
TBH_C2182	COG4372	Transposase
TBH_C2185	COG0270	DNA (cytosine-5-)-methyltransferase activity
TBH_C2189	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
TBH_C2192	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
TBH_C2193	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
TBH_C2193	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
TBH_C2196	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
TBH_C2199	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
TBH_C2201	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
TBH_C2206	COG2814	Major facilitator Superfamily
TBH_C2210	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
TBH_C2211	COG1538	Outer membrane efflux protein
TBH_C2213	COG1132	(ABC) transporter
TBH_C2215	COG4566	intracellular signal transduction
TBH_C2216	COG4191	Histidine kinase
TBH_C2219	COG0513	Belongs to the DEAD box helicase family
TBH_C2220	COG1671	Belongs to the UPF0178 family
TBH_C2227	COG1592	Rubrerythrin
TBH_C2228	COG0583	DNA-binding transcription factor activity
TBH_C2229	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
TBH_C2230	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
TBH_C2235	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
TBH_C2238	COG2885	chlorophyll binding
TBH_C2239	COG0823	Involved in the tonB-independent uptake of proteins
TBH_C2243	COG0824	Thioesterase
TBH_C2244	COG2255	four-way junction helicase activity
TBH_C2245	COG0632	four-way junction helicase activity
TBH_C2246	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
TBH_C2247	COG0217	transcriptional regulatory protein
TBH_C2248	COG2095	MarC family integral membrane protein
TBH_C2249	COG3706	GGDEF domain
TBH_C2252	COG0429	hydrolase of the alpha beta-hydrolase fold
TBH_C2254	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
TBH_C2257	COG0300	oxidoreductase activity
TBH_C2258	COG2918	glutathione biosynthetic process
TBH_C2259	COG0793	Belongs to the peptidase S41A family
TBH_C2261	COG3956	TIGRFAM MazG family protein
TBH_C2273	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
TBH_C2276	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
TBH_C2277	COG0297	glycogen (starch) synthase activity
TBH_C2279	COG1595	DNA-templated transcription, initiation
TBH_C2282	COG0058	SHG alpha-glucan phosphorylase activity
TBH_C2284	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
TBH_C2286	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
TBH_C2287	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
TBH_C2290	COG0642	Histidine kinase
TBH_C2291	COG0745	RESPONSE REGULATOR receiver
TBH_C2292	COG0300	oxidoreductase activity
TBH_C2295	COG1022	Amp-dependent synthetase and ligase
TBH_C2297	COG0717	Belongs to the dCTP deaminase family
TBH_C2303	COG0288	reversible hydration of carbon dioxide
TBH_C2307	COG0515	serine threonine protein kinase
TBH_C2307	COG2815	serine threonine protein kinase
TBH_C2313	COG1131	(ABC) transporter
TBH_C2317	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
TBH_C2319	COG0194	GDP metabolic process
TBH_C2320	COG1561	YicC-like family, N-terminal region
TBH_C2321	COG2815	serine threonine protein kinase
TBH_C2321	COG0515	serine threonine protein kinase
TBH_C2323	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
TBH_C2327	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
TBH_C2327	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
TBH_C2331	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
TBH_C2334	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
TBH_C2344	COG4191	Histidine kinase
TBH_C2345	COG4566	intracellular signal transduction
TBH_C2347	COG3258	Cytochrome c
TBH_C2353	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
TBH_C2354	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
TBH_C2360	COG0704	Plays a role in the regulation of phosphate uptake
TBH_C2361	COG1262	PFAM Formylglycine-generating sulfatase enzyme
TBH_C2370	COG3220	belongs to the UPF0276 family
TBH_C2373	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
TBH_C2375	COG0137	argininosuccinate synthase activity
TBH_C2377	COG0442	prolyl-tRNA aminoacylation
TBH_C2378	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
TBH_C2380	COG1489	DNA binding
TBH_C2383	COG1254	Belongs to the acylphosphatase family
TBH_C2384	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
TBH_C2387	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
TBH_C2388	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
TBH_C2391	COG1295	ribonuclease BN
TBH_C2391	COG1959	2 iron, 2 sulfur cluster binding
TBH_C2392	COG1393	Belongs to the ArsC family
TBH_C2395	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
TBH_C2396	COG1238	metal cluster binding
TBH_C2402	COG2974	May be involved in recombination
TBH_C2408	COG0277	FAD linked oxidase domain protein
TBH_C2409	COG0300	oxidoreductase activity
TBH_C2414	COG3264	Mechanosensitive ion channel
TBH_C2414	COG1511	domain protein
TBH_C2415	COG0205	6-phosphofructokinase activity
TBH_C2422	COG2890	protein-(glutamine-N5) methyltransferase activity
TBH_C2423	COG4191	Histidine kinase
TBH_C2426	COG0583	DNA-binding transcription factor activity
TBH_C2427	COG2067	long-chain fatty acid transport protein
TBH_C2428	COG1902	pentaerythritol trinitrate reductase activity
TBH_C2429	COG2210	Belongs to the sulfur carrier protein TusA family
TBH_C2430	COG0425	Belongs to the sulfur carrier protein TusA family
TBH_C2431	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
TBH_C2432	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
TBH_C2432	COG1648	precorrin-2 dehydrogenase activity
TBH_C2434	COG2197	response regulator
TBH_C2435	COG3850	Histidine kinase
TBH_C2436	COG0617	tRNA 3'-terminal CCA addition
TBH_C2437	COG5265	(ABC) transporter
TBH_C2444	COG0308	aminopeptidase N
TBH_C2446	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
TBH_C2450	COG1797	cobyrinic acid a,c-diamide synthase activity
TBH_C2457	COG2920	part of a sulfur-relay system
TBH_C2459	COG2923	Belongs to the DsrF TusC family
TBH_C2460	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
TBH_C2461	COG2221	Nitrite and sulphite reductase 4Fe-4S
TBH_C2462	COG2221	Nitrite and sulphite reductase 4Fe-4S
TBH_C2466	COG2920	part of a sulfur-relay system
TBH_C2469	COG3706	GGDEF domain
TBH_C2476	COG4783	chaperone-mediated protein folding
TBH_C2481	COG3437	response regulator, receiver
TBH_C2481	COG2770	Histidine kinase
TBH_C2482	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
TBH_C2488	COG0784	Response regulator, receiver
TBH_C2488	COG2205	protein histidine kinase activity
TBH_C2488	COG5002	protein histidine kinase activity
TBH_C2497	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
TBH_C2498	COG3012	SEC-C Motif Domain Protein
TBH_C2498	COG3318	Belongs to the UPF0149 family
TBH_C2499	COG0339	signal peptide processing
TBH_C2501	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
TBH_C2502	COG0306	phosphate transporter
TBH_C2503	COG1368	sulfuric ester hydrolase activity
TBH_C2504	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
TBH_C2509	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
TBH_C2510	COG0581	inorganic phosphate transmembrane transporter activity
TBH_C2511	COG0573	inorganic phosphate transmembrane transporter activity
TBH_C2514	COG2890	protein-(glutamine-N5) methyltransferase activity
TBH_C2515	COG0318	PFAM AMP-dependent synthetase and ligase
TBH_C2517	COG0367	asparagine synthase
TBH_C2518	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
TBH_C2519	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
TBH_C2526	COG0438	transferase activity, transferring glycosyl groups
TBH_C2536	COG1216	Glycosyl transferase, family 2
TBH_C2537	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
TBH_C2538	COG0438	transferase activity, transferring glycosyl groups
TBH_C2541	COG1216	Glycosyl transferase, family 2
TBH_C2541	COG0463	Glycosyl transferase, family 2
TBH_C2542	COG0438	transferase activity, transferring glycosyl groups
TBH_C2545	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
TBH_C2547	COG0583	DNA-binding transcription factor activity
TBH_C2548	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
TBH_C2550	COG0745	RESPONSE REGULATOR receiver
TBH_C2550	COG2972	Histidine kinase
TBH_C2551	COG0165	Argininosuccinate lyase
TBH_C2553	COG0004	ammonium transporteR
TBH_C2554	COG0347	Belongs to the P(II) protein family
TBH_C2557	COG0606	chelatase, subunit chli
TBH_C2559	COG0156	8-amino-7-oxononanoate synthase activity
TBH_C2560	COG0784	Response regulator, receiver
TBH_C2560	COG5002	protein histidine kinase activity
TBH_C2560	COG2198	Histidine kinase
TBH_C2563	COG0488	(ABC) transporter
TBH_C2566	COG3065	identical protein binding
TBH_C2568	COG3100	YcgL domain-containing protein
TBH_C2572	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
TBH_C2574	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
TBH_C2576	COG0469	pyruvate kinase activity
TBH_C2577	COG0126	phosphoglycerate kinase activity
TBH_C2578	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
TBH_C2579	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
TBH_C2581	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
TBH_C2582	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
TBH_C2583	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
TBH_C2584	COG1385	rRNA (uridine-N3-)-methyltransferase activity
TBH_C2586	COG0643	Histidine kinase
TBH_C2586	COG2198	Histidine kinase
TBH_C2587	COG0840	transmembrane signaling receptor activity
TBH_C2593	COG0189	ligase activity
TBH_C2595	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
TBH_C2596	COG1678	Uncharacterized ACR, COG1678
TBH_C2597	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
TBH_C2598	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
TBH_C2599	COG0540	Belongs to the ATCase OTCase family
TBH_C2607	COG1872	DUF167
TBH_C2611	COG2807	transmembrane transport
TBH_C2612	COG0708	Exodeoxyribonuclease III
TBH_C2616	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
TBH_C2619	COG0501	Belongs to the peptidase M48B family
TBH_C2622	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
TBH_C2622	COG0543	2 iron, 2 sulfur cluster binding
TBH_C2623	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
TBH_C2637	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
TBH_C2638	COG2204	response regulator
TBH_C2640	COG5002	protein histidine kinase activity
TBH_C2642	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
TBH_C2643	COG1194	a g-specific adenine glycosylase
TBH_C2645	COG1999	signal sequence binding
TBH_C2648	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
TBH_C2649	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
TBH_C2650	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
TBH_C2654	COG0012	GTP binding
TBH_C2657	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
TBH_C2660	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
TBH_C2661	COG0739	heme binding
TBH_C2661	COG1196	nuclear chromosome segregation
TBH_C2661	COG0741	lytic transglycosylase activity
TBH_C2662	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
TBH_C2663	COG3706	GGDEF domain
TBH_C2664	COG0316	Belongs to the HesB IscA family
TBH_C2668	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
TBH_C2671	COG0786	glutamate:sodium symporter activity
TBH_C2686	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
TBH_C2694	COG0210	DNA helicase
TBH_C2701	COG3022	response to hydroperoxide
TBH_C2702	COG0659	secondary active sulfate transmembrane transporter activity
TBH_C2703	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
TBH_C2710	COG2801	Transposase and inactivated derivatives
TBH_C2728	COG2920	part of a sulfur-relay system
TBH_C2729	COG0577	efflux transmembrane transporter activity
TBH_C2729	COG1136	(ABC) transporter
TBH_C2730	COG1136	(ABC) transporter
TBH_C2730	COG0577	efflux transmembrane transporter activity
TBH_C2734	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
TBH_C2735	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
TBH_C2736	COG1466	dna polymerase III delta subunit
TBH_C2738	COG0495	leucyl-tRNA aminoacylation
TBH_C2739	COG1999	signal sequence binding
TBH_C2742	COG0535	radical SAM domain protein
TBH_C2744	COG3706	GGDEF domain
TBH_C2747	COG1410	methionine synthase
TBH_C2747	COG0646	methionine synthase
TBH_C2749	COG1444	tRNA N-acetyltransferase activity
TBH_C2753	COG2353	YceI-like domain
TBH_C2754	COG3038	cytochrome b561
TBH_C2757	COG0739	heme binding
TBH_C2757	COG0741	lytic transglycosylase activity
TBH_C2757	COG1196	nuclear chromosome segregation
TBH_C2760	COG0667	Aldo Keto reductase
TBH_C2762	COG0482	sulfurtransferase activity
TBH_C2763	COG0425	Belongs to the sulfur carrier protein TusA family
TBH_C2764	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
TBH_C2765	COG0174	glutamine synthetase
TBH_C2772	COG0314	molybdopterin synthase activity
TBH_C2773	COG0714	Associated with various cellular activities
TBH_C2774	COG1233	COG1233 Phytoene dehydrogenase and related
TBH_C2777	COG2048	Heterodisulfide reductase, subunit B
TBH_C2787	COG2205	protein histidine kinase activity
TBH_C2788	COG0745	RESPONSE REGULATOR receiver
TBH_C2790	COG0842	Transport permease protein
TBH_C2791	COG0842	Transport permease protein
TBH_C2792	COG1131	(ABC) transporter
TBH_C2799	COG0438	transferase activity, transferring glycosyl groups
TBH_C2800	COG0859	PFAM glycosyl transferase family 9
TBH_C2801	COG0529	Catalyzes the synthesis of activated sulfate
TBH_C2805	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
TBH_C2808	COG0784	Response regulator, receiver
TBH_C2808	COG2205	protein histidine kinase activity
TBH_C2816	COG0840	transmembrane signaling receptor activity
TBH_C2829	COG4555	ABC transporter
TBH_C2830	COG1668	transmembrane transport
TBH_C2831	COG1278	Cold shock
TBH_C2832	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
TBH_C2833	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
TBH_C2842	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
TBH_C2846	COG1702	phosphate starvation-inducible protein PhoH
TBH_C2847	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
TBH_C2848	COG4535	Mg2 and Co2 transporter CorC
TBH_C2850	COG0815	Transfers the fatty acyl group on membrane lipoproteins
TBH_C2852	COG0432	Pfam Uncharacterised protein family UPF0047
TBH_C2854	COG0445	tRNA wobble uridine modification
TBH_C2855	COG0714	Associated with various cellular activities
TBH_C2859	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
TBH_C2860	COG0706	membrane insertase activity
TBH_C2861	COG0594	ribonuclease P activity
TBH_P103	COG4372	Transposase
TBH_P104	COG3436	PFAM IS66 Orf2 family protein
TBH_P203	COG3436	PFAM IS66 Orf2 family protein
TBH_P204	COG4372	Transposase
TBH_P207	COG1484	DNA-dependent DNA replication
TBH_P217	COG3093	addiction module antidote protein HigA