locus-tag	class	description
THMIRHAM_00010	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
THMIRHAM_00030	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
THMIRHAM_00040	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
THMIRHAM_00060	COG0187	DNA topoisomerase II activity
THMIRHAM_00120	COG2203	Gaf domain
THMIRHAM_00120	COG3706	GGDEF domain
THMIRHAM_00120	COG4251	negative regulation of phosphorylation
THMIRHAM_00120	COG5001	Diguanylate cyclase
THMIRHAM_00160	COG0009	L-threonylcarbamoyladenylate synthase
THMIRHAM_00170	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
THMIRHAM_00180	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
THMIRHAM_00180	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
THMIRHAM_00230	COG0218	Necessary for normal cell division and for the maintenance of normal septation
THMIRHAM_00240	COG1333	cytochrome c biogenesis protein
THMIRHAM_00250	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
THMIRHAM_00260	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
THMIRHAM_00290	COG0514	ATP-dependent DNA helicase (RecQ)
THMIRHAM_00310	COG0583	DNA-binding transcription factor activity
THMIRHAM_00330	COG2205	protein histidine kinase activity
THMIRHAM_00330	COG0784	Response regulator, receiver
THMIRHAM_00340	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
THMIRHAM_00370	COG4067	protein conserved in archaea
THMIRHAM_00370	COG0189	ligase activity
THMIRHAM_00410	COG1522	sequence-specific DNA binding
THMIRHAM_00420	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
THMIRHAM_00430	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
THMIRHAM_00460	COG0640	Transcriptional regulator
THMIRHAM_00470	COG0701	Predicted permease
THMIRHAM_00500	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
THMIRHAM_00520	COG0432	Pfam Uncharacterised protein family UPF0047
THMIRHAM_00530	COG0339	signal peptide processing
THMIRHAM_00570	COG1595	DNA-templated transcription, initiation
THMIRHAM_00590	COG2814	Major facilitator Superfamily
THMIRHAM_00620	COG2304	oxidoreductase activity
THMIRHAM_00660	COG0714	Associated with various cellular activities
THMIRHAM_00670	COG0840	transmembrane signaling receptor activity
THMIRHAM_00670	COG0840	transmembrane signaling receptor activity
THMIRHAM_00680	COG2759	Belongs to the formate--tetrahydrofolate ligase family
THMIRHAM_00690	COG0247	lactate metabolic process
THMIRHAM_00700	COG0277	FAD linked oxidase domain protein
THMIRHAM_00710	COG0277	FAD linked oxidase domain protein
THMIRHAM_00720	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
THMIRHAM_00750	COG2203	Gaf domain
THMIRHAM_00750	COG5001	Diguanylate cyclase
THMIRHAM_00750	COG4251	negative regulation of phosphorylation
THMIRHAM_00750	COG3706	GGDEF domain
THMIRHAM_00770	COG0500	methyltransferase
THMIRHAM_00780	COG2226	methyltransferase
THMIRHAM_00790	COG0741	lytic transglycosylase activity
THMIRHAM_00820	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
THMIRHAM_00840	COG0531	amino acid
THMIRHAM_00850	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
THMIRHAM_00860	COG1566	PFAM secretion protein HlyD family protein
THMIRHAM_00880	COG2132	Multicopper oxidase
THMIRHAM_00920	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
THMIRHAM_00920	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
THMIRHAM_00930	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
THMIRHAM_00950	COG0477	Major facilitator Superfamily
THMIRHAM_00960	COG0714	Associated with various cellular activities
THMIRHAM_01030	COG3118	belongs to the thioredoxin family
THMIRHAM_01080	COG0515	serine threonine protein kinase
THMIRHAM_01080	COG2815	serine threonine protein kinase
THMIRHAM_01100	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
THMIRHAM_01130	COG0165	Argininosuccinate lyase
THMIRHAM_01150	COG0181	hydroxymethylbilane synthase activity
THMIRHAM_01200	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
THMIRHAM_01200	COG0543	2 iron, 2 sulfur cluster binding
THMIRHAM_01220	COG0788	formyltetrahydrofolate deformylase activity
THMIRHAM_01230	COG1444	tRNA N-acetyltransferase activity
THMIRHAM_01240	COG5002	protein histidine kinase activity
THMIRHAM_01240	COG5001	Diguanylate cyclase
THMIRHAM_01250	COG2897	thiosulfate sulfurtransferase activity
THMIRHAM_01260	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
THMIRHAM_01270	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
THMIRHAM_01270	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
THMIRHAM_01330	COG2081	HI0933 family
THMIRHAM_01340	COG0577	efflux transmembrane transporter activity
THMIRHAM_01340	COG1136	(ABC) transporter
THMIRHAM_01350	COG0577	efflux transmembrane transporter activity
THMIRHAM_01350	COG1136	(ABC) transporter
THMIRHAM_01390	COG0678	peroxiredoxin activity
THMIRHAM_01390	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
THMIRHAM_01410	COG2200	EAL domain
THMIRHAM_01440	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
THMIRHAM_01460	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
THMIRHAM_01510	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
THMIRHAM_01520	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
THMIRHAM_01530	COG0314	molybdopterin synthase activity
THMIRHAM_01540	COG0303	'Molybdopterin
THMIRHAM_01550	COG0315	cyclic pyranopterin monophosphate synthase activity
THMIRHAM_01560	COG3706	GGDEF domain
THMIRHAM_01570	COG2827	Endonuclease containing a URI domain
THMIRHAM_01590	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
THMIRHAM_01620	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
THMIRHAM_01660	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
THMIRHAM_01680	COG1116	anion transmembrane transporter activity
THMIRHAM_01680	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
THMIRHAM_01710	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
THMIRHAM_01740	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
THMIRHAM_01770	COG2226	methyltransferase
THMIRHAM_01780	COG0596	Alpha beta hydrolase
THMIRHAM_01800	COG0156	8-amino-7-oxononanoate synthase activity
THMIRHAM_01810	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
THMIRHAM_01820	COG1040	competence protein
THMIRHAM_01830	COG1230	cation diffusion facilitator family transporter
THMIRHAM_01860	COG0840	transmembrane signaling receptor activity
THMIRHAM_01880	COG0805	protein transport
THMIRHAM_01890	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
THMIRHAM_01900	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
THMIRHAM_01910	COG0537	adenosine 5'-monophosphoramidase activity
THMIRHAM_01920	COG0140	phosphoribosyl-ATP diphosphatase activity
THMIRHAM_01930	COG0107	imidazoleglycerol-phosphate synthase activity
THMIRHAM_01940	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
THMIRHAM_01950	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
THMIRHAM_01960	COG0131	Imidazoleglycerol-phosphate dehydratase
THMIRHAM_01970	COG3278	Belongs to the heme-copper respiratory oxidase family
THMIRHAM_02020	COG0348	domain, Protein
THMIRHAM_02040	COG2217	Heavy metal translocating P-type atpase
THMIRHAM_02100	COG1490	D-aminoacyl-tRNA deacylase activity
THMIRHAM_02120	COG0784	Response regulator, receiver
THMIRHAM_02120	COG2205	protein histidine kinase activity
THMIRHAM_02140	COG1217	gtp-binding protein TYPA
THMIRHAM_02160	COG2391	methyltransferase activity
THMIRHAM_02170	COG2354	Protein conserved in bacteria
THMIRHAM_02200	COG0646	methionine synthase
THMIRHAM_02200	COG1410	methionine synthase
THMIRHAM_02220	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
THMIRHAM_02230	COG0730	response to heat
THMIRHAM_02240	COG2258	MOSC domain
THMIRHAM_02260	COG0037	tRNA processing
THMIRHAM_02320	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
THMIRHAM_02330	COG0569	domain protein
THMIRHAM_02340	COG2204	response regulator
THMIRHAM_02350	COG5000	phosphorelay sensor kinase activity
THMIRHAM_02370	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
THMIRHAM_02370	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
THMIRHAM_02380	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
THMIRHAM_02390	COG0242	peptide deformylase activity
THMIRHAM_02400	COG0758	DNA mediated transformation
THMIRHAM_02430	COG0018	arginyl-trna synthetase
THMIRHAM_02470	COG0606	chelatase, subunit chli
THMIRHAM_02500	COG2197	response regulator
THMIRHAM_02510	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
THMIRHAM_02530	COG2200	EAL domain
THMIRHAM_02560	COG1454	alcohol dehydrogenase
THMIRHAM_02570	COG0210	DNA helicase
THMIRHAM_02580	COG2813	Specifically methylates the guanine in position
THMIRHAM_02610	COG0585	pseudouridine synthase activity
THMIRHAM_02620	COG0784	Response regulator, receiver
THMIRHAM_02620	COG5002	protein histidine kinase activity
THMIRHAM_02640	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
THMIRHAM_02690	COG1929	Belongs to the glycerate kinase type-1 family
THMIRHAM_02710	COG5001	Diguanylate cyclase
THMIRHAM_02710	COG3300	MHYT domain
THMIRHAM_02720	COG0456	acetyltransferase
THMIRHAM_02730	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
THMIRHAM_02740	COG1917	Cupin 2, conserved barrel domain protein
THMIRHAM_02750	COG0527	aspartate kinase activity
THMIRHAM_02770	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
THMIRHAM_02800	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
THMIRHAM_02810	COG3100	YcgL domain-containing protein
THMIRHAM_02830	COG0617	tRNA 3'-terminal CCA addition
THMIRHAM_02860	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
THMIRHAM_02870	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
THMIRHAM_02880	COG0126	phosphoglycerate kinase activity
THMIRHAM_02890	COG0469	pyruvate kinase activity
THMIRHAM_02900	COG0191	fructose-bisphosphate aldolase activity
THMIRHAM_02930	COG3437	response regulator, receiver
THMIRHAM_02940	COG0784	Response regulator, receiver
THMIRHAM_02940	COG2205	protein histidine kinase activity
THMIRHAM_02940	COG5002	protein histidine kinase activity
THMIRHAM_02990	COG1850	ribulose-bisphosphate carboxylase activity
THMIRHAM_03010	COG0583	DNA-binding transcription factor activity
THMIRHAM_03020	COG1850	ribulose-bisphosphate carboxylase activity
THMIRHAM_03070	COG0288	reversible hydration of carbon dioxide
THMIRHAM_03140	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
THMIRHAM_03150	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
THMIRHAM_03180	COG0546	phosphoglycolate phosphatase activity
THMIRHAM_03200	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
THMIRHAM_03210	COG0512	Glutamine amidotransferase of anthranilate synthase
THMIRHAM_03220	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
THMIRHAM_03230	COG2832	Protein of unknown function (DUF454)
THMIRHAM_03240	COG0134	indole-3-glycerol-phosphate synthase activity
THMIRHAM_03270	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
THMIRHAM_03280	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
THMIRHAM_03300	COG1765	OsmC-like protein
THMIRHAM_03330	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
THMIRHAM_03330	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
THMIRHAM_03340	COG0564	pseudouridine synthase activity
THMIRHAM_03350	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
THMIRHAM_03360	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
THMIRHAM_03380	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
THMIRHAM_03390	COG0081	regulation of translation
THMIRHAM_03400	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
THMIRHAM_03410	COG0222	ribosome binding
THMIRHAM_03420	COG0085	RNA polymerase activity
THMIRHAM_03430	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
THMIRHAM_03440	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
THMIRHAM_03450	COG0049	tRNA binding
THMIRHAM_03460	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
THMIRHAM_03470	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
THMIRHAM_03480	COG0051	transcription antitermination factor activity, RNA binding
THMIRHAM_03490	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
THMIRHAM_03500	COG0088	Forms part of the polypeptide exit tunnel
THMIRHAM_03510	COG0089	rRNA binding
THMIRHAM_03520	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
THMIRHAM_03530	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
THMIRHAM_03540	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
THMIRHAM_03550	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
THMIRHAM_03560	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
THMIRHAM_03570	COG0255	Belongs to the universal ribosomal protein uL29 family
THMIRHAM_03580	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
THMIRHAM_03590	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
THMIRHAM_03600	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
THMIRHAM_03610	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
THMIRHAM_03620	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
THMIRHAM_03630	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
THMIRHAM_03640	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
THMIRHAM_03650	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
THMIRHAM_03660	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
THMIRHAM_03670	COG1841	ribosomal large subunit assembly
THMIRHAM_03680	COG0200	Binds to the 23S rRNA
THMIRHAM_03690	COG0201	protein transport
THMIRHAM_03700	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
THMIRHAM_03710	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
THMIRHAM_03720	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
THMIRHAM_03730	COG0202	RNA polymerase activity
THMIRHAM_03740	COG0203	ribosomal protein L17
THMIRHAM_03760	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
THMIRHAM_03800	COG2814	Major facilitator Superfamily
THMIRHAM_03810	COG0629	single-stranded DNA binding
THMIRHAM_03820	COG1196	nuclear chromosome segregation
THMIRHAM_03820	COG3264	Mechanosensitive ion channel
THMIRHAM_03850	COG0668	transmembrane transport
THMIRHAM_03880	COG1253	flavin adenine dinucleotide binding
THMIRHAM_03890	COG2239	Acts as a magnesium transporter
THMIRHAM_03900	COG0189	ligase activity
THMIRHAM_03900	COG4067	protein conserved in archaea
THMIRHAM_03910	COG0189	ligase activity
THMIRHAM_03990	COG0142	geranyltranstransferase activity
THMIRHAM_04000	COG0261	This protein binds to 23S rRNA in the presence of protein L20
THMIRHAM_04010	COG0211	Belongs to the bacterial ribosomal protein bL27 family
THMIRHAM_04020	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
THMIRHAM_04030	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
THMIRHAM_04040	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
THMIRHAM_04050	COG0459	protein refolding
THMIRHAM_04070	COG3300	MHYT domain
THMIRHAM_04070	COG5001	Diguanylate cyclase
THMIRHAM_04080	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
THMIRHAM_04090	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
THMIRHAM_04100	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
THMIRHAM_04110	COG0316	Belongs to the HesB IscA family
THMIRHAM_04130	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
THMIRHAM_04140	COG0739	heme binding
THMIRHAM_04150	COG0425	Belongs to the sulfur carrier protein TusA family
THMIRHAM_04170	COG0751	glycine-tRNA ligase activity
THMIRHAM_04180	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
THMIRHAM_04240	COG0840	transmembrane signaling receptor activity
THMIRHAM_04260	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
THMIRHAM_04270	COG0259	pyridoxamine-phosphate oxidase activity
THMIRHAM_04300	COG0840	transmembrane signaling receptor activity
THMIRHAM_04300	COG0840	transmembrane signaling receptor activity
THMIRHAM_04330	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
THMIRHAM_04360	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
THMIRHAM_04370	COG1360	Flagellar Motor Protein
THMIRHAM_04380	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
THMIRHAM_04390	COG2890	protein-(glutamine-N5) methyltransferase activity
THMIRHAM_04400	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
THMIRHAM_04410	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
THMIRHAM_04430	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
THMIRHAM_04440	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
THMIRHAM_04450	COG0193	aminoacyl-tRNA hydrolase activity
THMIRHAM_04460	COG0012	GTP binding
THMIRHAM_04490	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
THMIRHAM_04510	COG2226	methyltransferase
THMIRHAM_04530	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
THMIRHAM_04540	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
THMIRHAM_04570	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
THMIRHAM_04590	COG2963	transposase activity
THMIRHAM_04600	COG2801	Transposase and inactivated derivatives
THMIRHAM_04610	COG1519	Transferase
THMIRHAM_04620	COG0517	IMP dehydrogenase activity
THMIRHAM_04620	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
THMIRHAM_04650	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
THMIRHAM_04650	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
THMIRHAM_04660	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
THMIRHAM_04670	COG0837	glucose binding
THMIRHAM_04680	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
THMIRHAM_04710	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
THMIRHAM_04720	COG0297	glycogen (starch) synthase activity
THMIRHAM_04730	COG0058	SHG alpha-glucan phosphorylase activity
THMIRHAM_04750	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
THMIRHAM_04760	COG1086	Polysaccharide biosynthesis protein
THMIRHAM_04770	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
THMIRHAM_04780	COG1083	cytidylyl-transferase
THMIRHAM_04790	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
THMIRHAM_04810	COG2089	acid synthase
THMIRHAM_04880	COG0297	glycogen (starch) synthase activity
THMIRHAM_04890	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
THMIRHAM_04910	COG1793	dna ligase
THMIRHAM_04930	COG0436	Aminotransferase
THMIRHAM_04940	COG0556	nucleotide-excision repair
THMIRHAM_05020	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
THMIRHAM_05030	COG0795	lipopolysaccharide-transporting ATPase activity
THMIRHAM_05040	COG0795	lipopolysaccharide-transporting ATPase activity
THMIRHAM_05070	COG0166	Belongs to the GPI family
THMIRHAM_05080	COG1210	Utp--glucose-1-phosphate uridylyltransferase
THMIRHAM_05100	COG1131	(ABC) transporter
THMIRHAM_05110	COG0842	Transport permease protein
THMIRHAM_05120	COG2124	cytochrome p450
THMIRHAM_05150	COG2124	cytochrome p450
THMIRHAM_05410	COG0438	transferase activity, transferring glycosyl groups
THMIRHAM_05410	COG1216	Glycosyl transferase, family 2
THMIRHAM_05420	COG0175	sulfate reduction
THMIRHAM_05440	COG2895	sulfate adenylyltransferase (ATP) activity
THMIRHAM_05450	COG0471	metal ion transport
THMIRHAM_05450	COG3273	potassium ion transport
THMIRHAM_05460	COG0529	Catalyzes the synthesis of activated sulfate
THMIRHAM_05500	COG4974	Belongs to the 'phage' integrase family
THMIRHAM_05560	COG0732	type I restriction modification DNA specificity domain
THMIRHAM_05640	COG5001	Diguanylate cyclase
THMIRHAM_05650	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
THMIRHAM_05660	COG0343	queuine tRNA-ribosyltransferase activity
THMIRHAM_05670	COG1862	Preprotein translocase
THMIRHAM_05680	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
THMIRHAM_05690	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
THMIRHAM_05700	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
THMIRHAM_05720	COG2239	Acts as a magnesium transporter
THMIRHAM_05740	COG1137	ATPase activity
THMIRHAM_05770	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
THMIRHAM_05800	COG1127	ABC transporter
THMIRHAM_05810	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
THMIRHAM_05820	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
THMIRHAM_05850	COG1131	(ABC) transporter
THMIRHAM_05860	COG0842	Transport permease protein
THMIRHAM_05880	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
THMIRHAM_05890	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
THMIRHAM_05900	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
THMIRHAM_05910	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
THMIRHAM_05920	COG0723	plastoquinol--plastocyanin reductase activity
THMIRHAM_05930	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
THMIRHAM_05940	COG2857	Cytochrome c1
THMIRHAM_05950	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
THMIRHAM_05970	COG0784	Response regulator, receiver
THMIRHAM_05970	COG2198	Histidine kinase
THMIRHAM_05970	COG5002	protein histidine kinase activity
THMIRHAM_05980	COG0483	inositol monophosphate 1-phosphatase activity
THMIRHAM_05990	COG4536	flavin adenine dinucleotide binding
THMIRHAM_06010	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
THMIRHAM_06020	COG0228	four-way junction DNA binding
THMIRHAM_06030	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
THMIRHAM_06040	COG0336	Belongs to the RNA methyltransferase TrmD family
THMIRHAM_06050	COG0335	large ribosomal subunit rRNA binding
THMIRHAM_06060	COG4974	Belongs to the 'phage' integrase family
THMIRHAM_06070	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
THMIRHAM_06100	COG4991	sh3 domain protein
THMIRHAM_06110	COG0525	valine-tRNA ligase activity
THMIRHAM_06120	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
THMIRHAM_06150	COG0004	ammonium transporteR
THMIRHAM_06160	COG0347	Belongs to the P(II) protein family
THMIRHAM_06200	COG0174	glutamine synthetase
THMIRHAM_06210	COG0573	inorganic phosphate transmembrane transporter activity
THMIRHAM_06220	COG0581	inorganic phosphate transmembrane transporter activity
THMIRHAM_06230	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
THMIRHAM_06250	COG0745	RESPONSE REGULATOR receiver
THMIRHAM_06270	COG0306	phosphate transporter
THMIRHAM_06330	COG0271	Belongs to the BolA IbaG family
THMIRHAM_06350	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
THMIRHAM_06360	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
THMIRHAM_06380	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
THMIRHAM_06390	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
THMIRHAM_06400	COG3178	'Phosphotransferase
THMIRHAM_06410	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
THMIRHAM_06420	COG0840	transmembrane signaling receptor activity
THMIRHAM_06430	COG1187	pseudouridine synthase activity
THMIRHAM_06450	COG1278	Cold shock
THMIRHAM_06470	COG0385	Bile acid
THMIRHAM_06480	COG3022	response to hydroperoxide
THMIRHAM_06520	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
THMIRHAM_06530	COG0321	lipoyl(octanoyl) transferase activity
THMIRHAM_06540	COG2921	Belongs to the UPF0250 family
THMIRHAM_06550	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
THMIRHAM_06560	COG1686	Belongs to the peptidase S11 family
THMIRHAM_06570	COG0772	Belongs to the SEDS family
THMIRHAM_06580	COG0768	penicillin binding
THMIRHAM_06600	COG1792	Involved in formation and maintenance of cell shape
THMIRHAM_06610	COG1077	Cell shape determining protein MreB Mrl
THMIRHAM_06620	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
THMIRHAM_06630	COG0154	amidase activity
THMIRHAM_06640	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
THMIRHAM_06670	COG5002	protein histidine kinase activity
THMIRHAM_06670	COG2205	protein histidine kinase activity
THMIRHAM_06670	COG0784	Response regulator, receiver
THMIRHAM_06680	COG3437	response regulator, receiver
THMIRHAM_06690	COG0501	Belongs to the peptidase M48B family
THMIRHAM_06710	COG0133	tryptophan synthase activity
THMIRHAM_06740	COG0848	biopolymer transport protein
THMIRHAM_06750	COG0811	peptide transport
THMIRHAM_06770	COG0560	Phosphoserine phosphatase
THMIRHAM_06810	COG0518	GMP synthase (glutamine-hydrolyzing) activity
THMIRHAM_06810	COG0519	Catalyzes the synthesis of GMP from XMP
THMIRHAM_06820	COG0590	tRNA wobble adenosine to inosine editing
THMIRHAM_06830	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
THMIRHAM_06840	COG0643	Histidine kinase
THMIRHAM_06840	COG2198	Histidine kinase
THMIRHAM_06880	COG0326	Molecular chaperone. Has ATPase activity
THMIRHAM_06890	COG0488	(ABC) transporter
THMIRHAM_06950	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
THMIRHAM_06970	COG0545	Peptidyl-prolyl cis-trans isomerase
THMIRHAM_07030	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
THMIRHAM_07040	COG1546	Belongs to the CinA family
THMIRHAM_07050	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
THMIRHAM_07070	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
THMIRHAM_07080	COG0527	aspartate kinase activity
THMIRHAM_07100	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
THMIRHAM_07170	COG0617	tRNA 3'-terminal CCA addition
THMIRHAM_07180	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
THMIRHAM_07190	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
THMIRHAM_07200	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
THMIRHAM_07210	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
THMIRHAM_07230	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
THMIRHAM_07240	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
THMIRHAM_07250	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
THMIRHAM_07260	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
THMIRHAM_07270	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
THMIRHAM_07270	COG0301	tRNA thio-modification
THMIRHAM_07280	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
THMIRHAM_07300	COG0557	exoribonuclease II activity
THMIRHAM_07310	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
THMIRHAM_07330	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
THMIRHAM_07340	COG2885	chlorophyll binding
THMIRHAM_07350	COG0308	aminopeptidase N
THMIRHAM_07450	COG0784	Response regulator, receiver
THMIRHAM_07450	COG0835	chemotaxis
THMIRHAM_07470	COG1815	bacterial-type flagellum-dependent cell motility
THMIRHAM_07480	COG1558	bacterial-type flagellum-dependent cell motility
THMIRHAM_07490	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
THMIRHAM_07510	COG4786	Flagellar basal body rod
THMIRHAM_07520	COG4786	Flagellar basal body rod
THMIRHAM_07530	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
THMIRHAM_07550	COG1706	bacterial-type flagellum-dependent cell motility
THMIRHAM_07590	COG0741	lytic transglycosylase activity
THMIRHAM_07620	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
THMIRHAM_07630	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
THMIRHAM_07720	COG1677	Flagellar hook-basal body complex protein FliE
THMIRHAM_07740	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
THMIRHAM_07800	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
THMIRHAM_07810	COG1360	Flagellar Motor Protein
THMIRHAM_07860	COG1338	Plays a role in the flagellum-specific transport system
THMIRHAM_07960	COG0784	Response regulator, receiver
THMIRHAM_07960	COG2198	Histidine kinase
THMIRHAM_07960	COG0643	Histidine kinase
THMIRHAM_07970	COG0835	chemotaxis
THMIRHAM_07980	COG2257	FlhB HrpN YscU SpaS Family
THMIRHAM_08000	COG0745	RESPONSE REGULATOR receiver
THMIRHAM_08010	COG0835	chemotaxis
THMIRHAM_08030	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
THMIRHAM_08040	COG2201	protein-glutamate methylesterase activity
THMIRHAM_08070	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
THMIRHAM_08070	COG3323	Protein of unknown function (DUF1653)
THMIRHAM_08080	COG0545	Peptidyl-prolyl cis-trans isomerase
THMIRHAM_08090	COG0492	ferredoxin-NADP+ reductase activity
THMIRHAM_08100	COG1674	ftsk spoiiie
THMIRHAM_08110	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
THMIRHAM_08120	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
THMIRHAM_08130	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
THMIRHAM_08140	COG0404	The glycine cleavage system catalyzes the degradation of glycine
THMIRHAM_08150	COG0509	glycine decarboxylation via glycine cleavage system
THMIRHAM_08160	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
THMIRHAM_08160	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
THMIRHAM_08180	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
THMIRHAM_08200	COG2205	protein histidine kinase activity
THMIRHAM_08210	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
THMIRHAM_08220	COG2847	Copper chaperone PCu(A)C
THMIRHAM_08260	COG1429	ligase activity, forming nitrogen-metal bonds
THMIRHAM_08270	COG4771	TonB-dependent receptor
THMIRHAM_08300	COG0564	pseudouridine synthase activity
THMIRHAM_08310	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
THMIRHAM_08320	COG1530	ribonuclease E activity
THMIRHAM_08340	COG0546	phosphoglycolate phosphatase activity
THMIRHAM_08350	COG0424	maF-like protein
THMIRHAM_08370	COG0333	Belongs to the bacterial ribosomal protein bL32 family
THMIRHAM_08380	COG0416	fatty acid biosynthetic process
THMIRHAM_08390	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
THMIRHAM_08400	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
THMIRHAM_08420	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
THMIRHAM_08430	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
THMIRHAM_08440	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
THMIRHAM_08460	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
THMIRHAM_08470	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
THMIRHAM_08480	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
THMIRHAM_08490	COG0084	hydrolase, TatD family'
THMIRHAM_08500	COG1132	(ABC) transporter
THMIRHAM_08510	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
THMIRHAM_08520	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
THMIRHAM_08580	COG0439	Biotin carboxylase
THMIRHAM_08590	COG3665	Urea carboxylase-associated protein
THMIRHAM_08610	COG0864	Transcriptional regulator
THMIRHAM_08620	COG1116	anion transmembrane transporter activity
THMIRHAM_08630	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
THMIRHAM_08640	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
THMIRHAM_08640	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
THMIRHAM_08650	COG1643	Atp-dependent helicase
THMIRHAM_08660	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
THMIRHAM_08680	COG2801	Transposase and inactivated derivatives
THMIRHAM_08700	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
THMIRHAM_08720	COG5002	protein histidine kinase activity
THMIRHAM_08720	COG5001	Diguanylate cyclase
THMIRHAM_08740	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
THMIRHAM_08750	COG0318	PFAM AMP-dependent synthetase and ligase
THMIRHAM_08830	COG1028	Short-chain dehydrogenase reductase Sdr
THMIRHAM_08910	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
THMIRHAM_08940	COG2914	Belongs to the UPF0125 (RnfH) family
THMIRHAM_08960	COG0735	belongs to the Fur family
THMIRHAM_08970	COG0497	DNA recombination
THMIRHAM_08980	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
THMIRHAM_08990	COG1420	regulation of RNA biosynthetic process
THMIRHAM_09000	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
THMIRHAM_09010	COG0443	Heat shock 70 kDa protein
THMIRHAM_09020	COG0484	heat shock protein binding
THMIRHAM_09030	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
THMIRHAM_09040	COG0791	NLP P60 protein
THMIRHAM_09060	COG1355	regulation of microtubule-based process
THMIRHAM_09080	COG0505	Belongs to the CarA family
THMIRHAM_09100	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
THMIRHAM_09130	COG2833	Protein of unknown function (DUF455)
THMIRHAM_09140	COG4106	trans-aconitate 2-methyltransferase activity
THMIRHAM_09150	COG1940	carbohydrate kinase activity
THMIRHAM_09170	COG1671	Belongs to the UPF0178 family
THMIRHAM_09180	COG0513	Belongs to the DEAD box helicase family
THMIRHAM_09200	COG0300	oxidoreductase activity
THMIRHAM_09210	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
THMIRHAM_09230	COG0784	Response regulator, receiver
THMIRHAM_09230	COG5002	protein histidine kinase activity
THMIRHAM_09230	COG2198	Histidine kinase
THMIRHAM_09270	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
THMIRHAM_09330	COG0720	synthase
THMIRHAM_09340	COG0142	geranyltranstransferase activity
THMIRHAM_09350	COG0450	alkyl hydroperoxide reductase
THMIRHAM_09390	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
THMIRHAM_09400	COG0481	GTPase activity
THMIRHAM_09420	COG0571	ribonuclease III activity
THMIRHAM_09430	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
THMIRHAM_09440	COG1381	Involved in DNA repair and RecF pathway recombination
THMIRHAM_09450	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
THMIRHAM_09460	COG0736	holo-[acyl-carrier-protein] synthase activity
THMIRHAM_09500	COG2391	methyltransferase activity
THMIRHAM_09540	COG1136	(ABC) transporter
THMIRHAM_09580	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
THMIRHAM_09630	COG0004	ammonium transporteR
THMIRHAM_09640	COG1067	ATP-dependent peptidase activity
THMIRHAM_09650	COG2801	Transposase and inactivated derivatives
THMIRHAM_09690	COG0658	competence protein
THMIRHAM_09690	COG2333	competence protein COMEC
THMIRHAM_09700	COG1663	tetraacyldisaccharide 4'-kinase activity
THMIRHAM_09710	COG2835	tetraacyldisaccharide 4'-kinase activity
THMIRHAM_09720	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
THMIRHAM_09750	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
THMIRHAM_09770	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
THMIRHAM_09780	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
THMIRHAM_09790	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
THMIRHAM_09830	COG1492	cobalamin metabolic process
THMIRHAM_09890	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
THMIRHAM_09910	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
THMIRHAM_09930	COG0513	Belongs to the DEAD box helicase family
THMIRHAM_09940	COG2801	Transposase and inactivated derivatives
THMIRHAM_09960	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
THMIRHAM_09970	COG5002	protein histidine kinase activity
THMIRHAM_09990	COG0328	RNA-DNA hybrid ribonuclease activity
THMIRHAM_10020	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
THMIRHAM_10030	COG4660	Part of a membrane complex involved in electron transport
THMIRHAM_10040	COG4659	FMN binding
THMIRHAM_10050	COG4658	electron transport chain
THMIRHAM_10060	COG4656	Part of a membrane complex involved in electron transport
THMIRHAM_10070	COG2878	Part of a membrane complex involved in electron transport
THMIRHAM_10080	COG4657	Part of a membrane complex involved in electron transport
THMIRHAM_10090	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
THMIRHAM_10090	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
THMIRHAM_10110	COG0489	protein tyrosine kinase activity
THMIRHAM_10120	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
THMIRHAM_10130	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
THMIRHAM_10140	COG1923	regulation of RNA biosynthetic process
THMIRHAM_10150	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
THMIRHAM_10160	COG0330	HflC and HflK could
THMIRHAM_10170	COG0330	HflC and HflK could
THMIRHAM_10180	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
THMIRHAM_10190	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
THMIRHAM_10200	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
THMIRHAM_10220	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
THMIRHAM_10240	COG2915	High frequency lysogenization protein hflD homolog
THMIRHAM_10250	COG0482	sulfurtransferase activity
THMIRHAM_10260	COG1187	pseudouridine synthase activity
THMIRHAM_10350	COG0513	Belongs to the DEAD box helicase family
THMIRHAM_10360	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
THMIRHAM_10370	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
THMIRHAM_10390	COG3228	Belongs to the MtfA family
THMIRHAM_10410	COG0328	RNA-DNA hybrid ribonuclease activity
THMIRHAM_10430	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
THMIRHAM_10450	COG0217	transcriptional regulatory protein
THMIRHAM_10480	COG2824	Alkylphosphonate utilization operon protein PhnA
THMIRHAM_10500	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
THMIRHAM_10510	COG0542	response to heat
THMIRHAM_10520	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
THMIRHAM_10540	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
THMIRHAM_10580	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
THMIRHAM_10640	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
THMIRHAM_10650	COG3162	membrane
THMIRHAM_10660	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
THMIRHAM_10680	COG2176	DNA-directed DNA polymerase activity
THMIRHAM_10690	COG0779	Required for maturation of 30S ribosomal subunits
THMIRHAM_10700	COG2251	uridine kinase activity
THMIRHAM_10700	COG0195	Participates in both transcription termination and antitermination
THMIRHAM_10710	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
THMIRHAM_10720	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
THMIRHAM_10730	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
THMIRHAM_10740	COG3615	Tellurite resistance protein tehB
THMIRHAM_10740	COG0500	methyltransferase
THMIRHAM_10760	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
THMIRHAM_10770	COG1185	polyribonucleotide nucleotidyltransferase activity
THMIRHAM_10790	COG2850	peptidyl-arginine hydroxylation
THMIRHAM_10820	COG1049	propionate catabolic process, 2-methylcitrate cycle
THMIRHAM_10850	COG0322	excinuclease ABC activity
THMIRHAM_10880	COG3707	response regulator
THMIRHAM_10910	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
THMIRHAM_10940	COG2022	thiamine diphosphate biosynthetic process
THMIRHAM_11010	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
THMIRHAM_11030	COG0446	pyridine nucleotide-disulphide oxidoreductase
THMIRHAM_11060	COG1136	(ABC) transporter
THMIRHAM_11070	COG0488	(ABC) transporter
THMIRHAM_11080	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
THMIRHAM_11090	COG0544	peptidyl-prolyl cis-trans isomerase activity
THMIRHAM_11100	COG0740	serine-type endopeptidase activity
THMIRHAM_11110	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
THMIRHAM_11120	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
THMIRHAM_11160	COG0601	transmembrane transport
THMIRHAM_11170	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
THMIRHAM_11180	COG4172	Belongs to the ABC transporter superfamily
THMIRHAM_11230	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
THMIRHAM_11270	COG1028	Short-chain dehydrogenase reductase Sdr
THMIRHAM_11290	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
THMIRHAM_11310	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
THMIRHAM_11320	COG0077	Prephenate dehydratase
THMIRHAM_11320	COG1605	Chorismate mutase
THMIRHAM_11330	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
THMIRHAM_11340	COG0287	Prephenate dehydrogenase
THMIRHAM_11350	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
THMIRHAM_11360	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
THMIRHAM_11380	COG0776	regulation of translation
THMIRHAM_11400	COG0284	orotidine-5'-phosphate decarboxylase activity
THMIRHAM_11410	COG0360	Binds together with S18 to 16S ribosomal RNA
THMIRHAM_11420	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
THMIRHAM_11440	COG0359	binds to the 23S rRNA
THMIRHAM_11460	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
THMIRHAM_11470	COG0494	nUDIX hydrolase
THMIRHAM_11490	COG0534	Mate efflux family protein
THMIRHAM_11500	COG3012	SEC-C Motif Domain Protein
THMIRHAM_11530	COG0745	RESPONSE REGULATOR receiver
THMIRHAM_11570	COG1393	Belongs to the ArsC family
THMIRHAM_11590	COG1570	exodeoxyribonuclease VII activity
THMIRHAM_11600	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
THMIRHAM_11610	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
THMIRHAM_11620	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
THMIRHAM_11680	COG1187	pseudouridine synthase activity
THMIRHAM_11690	COG1994	Peptidase M50
THMIRHAM_11700	COG0009	L-threonylcarbamoyladenylate synthase
THMIRHAM_11710	COG0613	PHP domain protein
THMIRHAM_11720	COG2917	probably involved in intracellular septation
THMIRHAM_11730	COG2350	Protein conserved in bacteria
THMIRHAM_11740	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
THMIRHAM_11760	COG0697	spore germination
THMIRHAM_11770	COG3028	Belongs to the UPF0307 family
THMIRHAM_11780	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
THMIRHAM_11800	COG1070	Carbohydrate kinase
THMIRHAM_11870	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
THMIRHAM_11900	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
THMIRHAM_11930	COG0436	Aminotransferase
THMIRHAM_11960	COG1238	metal cluster binding
THMIRHAM_11970	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
THMIRHAM_11980	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
THMIRHAM_11990	COG2840	Smr protein MutS2
THMIRHAM_12000	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
THMIRHAM_12010	COG0148	phosphopyruvate hydratase activity
THMIRHAM_12020	COG2877	3-deoxy-8-phosphooctulonate synthase activity
THMIRHAM_12030	COG0504	CTP synthase activity
THMIRHAM_12040	COG0037	tRNA processing
THMIRHAM_12050	COG0825	malonyl-CoA metabolic process
THMIRHAM_12070	COG1944	ATP diphosphatase activity
THMIRHAM_12100	COG0589	response to stress
THMIRHAM_12110	COG1214	PFAM Peptidase M22, glycoprotease
THMIRHAM_12120	COG1199	ATP-dependent helicase activity
THMIRHAM_12130	COG0257	Belongs to the bacterial ribosomal protein bL36 family
THMIRHAM_12140	COG0784	Response regulator, receiver
THMIRHAM_12140	COG0835	chemotaxis
THMIRHAM_12150	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
THMIRHAM_12160	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
THMIRHAM_12170	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
THMIRHAM_12180	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
THMIRHAM_12190	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
THMIRHAM_12230	COG0575	Belongs to the CDS family
THMIRHAM_12250	COG0233	cytoplasmic translational termination
THMIRHAM_12260	COG0528	UMP kinase activity
THMIRHAM_12270	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
THMIRHAM_12280	COG0052	Belongs to the universal ribosomal protein uS2 family
THMIRHAM_12290	COG0024	Methionine aminopeptidase
THMIRHAM_12300	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
THMIRHAM_12310	COG0346	lactoylglutathione lyase activity
THMIRHAM_12320	COG2171	N-acyltransferase activity
THMIRHAM_12330	COG1393	Belongs to the ArsC family
THMIRHAM_12340	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
THMIRHAM_12370	COG0733	neurotransmitter:sodium symporter activity
THMIRHAM_12390	COG0668	transmembrane transport
THMIRHAM_12400	COG1472	Belongs to the glycosyl hydrolase 3 family
THMIRHAM_12420	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
THMIRHAM_12430	COG0601	transmembrane transport
THMIRHAM_12440	COG1376	ErfK ybiS ycfS ynhG family protein
THMIRHAM_12480	COG2954	triphosphatase activity
THMIRHAM_12510	COG0840	transmembrane signaling receptor activity
THMIRHAM_12540	COG3706	GGDEF domain
THMIRHAM_12550	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
THMIRHAM_12560	COG0826	peptidase U32
THMIRHAM_12590	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
THMIRHAM_12630	COG1981	membrane
THMIRHAM_12640	COG1047	Peptidyl-prolyl cis-trans
THMIRHAM_12650	COG1047	Peptidyl-prolyl cis-trans
THMIRHAM_12660	COG0489	protein tyrosine kinase activity
THMIRHAM_12710	COG0243	molybdopterin cofactor binding
THMIRHAM_12710	COG3383	formate dehydrogenase (NAD+) activity
THMIRHAM_12730	COG2983	Belongs to the UPF0260 family
THMIRHAM_12740	COG0564	pseudouridine synthase activity
THMIRHAM_12750	COG4335	DNA alkylation repair
THMIRHAM_12780	COG1741	Belongs to the pirin family
THMIRHAM_12830	COG1902	pentaerythritol trinitrate reductase activity
THMIRHAM_12890	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
THMIRHAM_12980	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
THMIRHAM_13000	COG3706	GGDEF domain
THMIRHAM_13020	COG0745	RESPONSE REGULATOR receiver
THMIRHAM_13050	COG3706	GGDEF domain
THMIRHAM_13060	COG2801	Transposase and inactivated derivatives
THMIRHAM_13080	COG0513	Belongs to the DEAD box helicase family
THMIRHAM_13090	COG3530	Putative quorum-sensing-regulated virulence factor
THMIRHAM_13100	COG1301	dicarboxylic acid transport
THMIRHAM_13150	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
THMIRHAM_13160	COG0508	dehydrogenase complex catalyzes the overall conversion of
THMIRHAM_13180	COG1051	belongs to the nudix hydrolase family
THMIRHAM_13200	COG0716	FMN binding
THMIRHAM_13230	COG3023	N-Acetylmuramoyl-L-alanine amidase
THMIRHAM_13300	COG1496	oxidoreductase activity
THMIRHAM_13310	COG0564	pseudouridine synthase activity
THMIRHAM_13330	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
THMIRHAM_13330	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
THMIRHAM_13340	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
THMIRHAM_13350	COG0045	succinate-CoA ligase (ADP-forming) activity
THMIRHAM_13370	COG0544	peptidyl-prolyl cis-trans isomerase activity
THMIRHAM_13380	COG2199	diguanylate cyclase activity
THMIRHAM_13430	COG4628	conserved protein (DUF2132)
THMIRHAM_13500	COG1643	Atp-dependent helicase
THMIRHAM_13530	COG2801	Transposase and inactivated derivatives
THMIRHAM_13540	COG1047	Peptidyl-prolyl cis-trans
THMIRHAM_13550	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
THMIRHAM_13560	COG0328	RNA-DNA hybrid ribonuclease activity
THMIRHAM_13570	COG2226	methyltransferase
THMIRHAM_13580	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
THMIRHAM_13590	COG0741	lytic transglycosylase activity
THMIRHAM_13590	COG1388	LysM domain
THMIRHAM_13600	COG0741	lytic transglycosylase activity
THMIRHAM_13610	COG0215	cysteine-tRNA ligase activity
THMIRHAM_13640	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
THMIRHAM_13660	COG1301	dicarboxylic acid transport
THMIRHAM_13680	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
THMIRHAM_13690	COG0137	argininosuccinate synthase activity
THMIRHAM_13710	COG0688	phosphatidylethanolamine metabolic process
THMIRHAM_13720	COG0347	Belongs to the P(II) protein family
THMIRHAM_13730	COG1278	Cold shock
THMIRHAM_13750	COG1067	ATP-dependent peptidase activity
THMIRHAM_13770	COG2204	response regulator
THMIRHAM_13780	COG3852	Histidine kinase
THMIRHAM_13790	COG1321	iron dependent repressor
THMIRHAM_13820	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
THMIRHAM_13830	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
THMIRHAM_13860	COG0823	Involved in the tonB-independent uptake of proteins
THMIRHAM_13890	COG0811	peptide transport
THMIRHAM_13900	COG2255	four-way junction helicase activity
THMIRHAM_13910	COG0632	four-way junction helicase activity
THMIRHAM_13920	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
THMIRHAM_13930	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
THMIRHAM_13940	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
THMIRHAM_13960	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
THMIRHAM_13980	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
THMIRHAM_13990	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
THMIRHAM_14000	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
THMIRHAM_14010	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
THMIRHAM_14040	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
THMIRHAM_14040	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
THMIRHAM_14050	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
THMIRHAM_14060	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
THMIRHAM_14070	COG0488	(ABC) transporter
THMIRHAM_14110	COG2801	Transposase and inactivated derivatives
THMIRHAM_14140	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
THMIRHAM_14140	COG0047	phosphoribosylformylglycinamidine synthase activity
THMIRHAM_14160	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
THMIRHAM_14170	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
THMIRHAM_14180	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
THMIRHAM_14190	COG0583	DNA-binding transcription factor activity
THMIRHAM_14200	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
THMIRHAM_14210	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
THMIRHAM_14220	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
THMIRHAM_14230	COG0006	proline dipeptidase activity
THMIRHAM_14240	COG3079	Belongs to the UPF0149 family
THMIRHAM_14260	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
THMIRHAM_14270	COG0860	N-Acetylmuramoyl-L-alanine amidase
THMIRHAM_14280	COG0802	atpase or kinase
THMIRHAM_14300	COG0232	Belongs to the dGTPase family. Type 2 subfamily
THMIRHAM_14380	COG4221	oxidoreductase activity
THMIRHAM_14400	COG0442	prolyl-tRNA aminoacylation
THMIRHAM_14460	COG3122	Protein conserved in bacteria
THMIRHAM_14470	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
THMIRHAM_14480	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
THMIRHAM_14510	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
THMIRHAM_14540	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
THMIRHAM_14570	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
THMIRHAM_14580	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
THMIRHAM_14600	COG0717	Belongs to the dCTP deaminase family
THMIRHAM_14610	COG0189	ligase activity
THMIRHAM_14640	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
THMIRHAM_14690	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
THMIRHAM_14710	COG0352	thiamine-phosphate diphosphorylase activity
THMIRHAM_14720	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
THMIRHAM_14730	COG3101	peptidyl-lysine hydroxylation
THMIRHAM_14740	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
THMIRHAM_14750	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
THMIRHAM_14760	COG0205	6-phosphofructokinase activity
THMIRHAM_14820	COG2885	chlorophyll binding
THMIRHAM_14840	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
THMIRHAM_14890	COG1007	ATP synthesis coupled electron transport
THMIRHAM_14920	COG0713	ATP synthesis coupled electron transport
THMIRHAM_14940	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
THMIRHAM_14950	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
THMIRHAM_14960	COG1034	ATP synthesis coupled electron transport
THMIRHAM_14990	COG0649	NAD binding
THMIRHAM_15000	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
THMIRHAM_15010	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
THMIRHAM_15020	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
THMIRHAM_15040	COG0149	triose-phosphate isomerase activity
THMIRHAM_15050	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
THMIRHAM_15060	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
THMIRHAM_15080	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
THMIRHAM_15090	COG1534	Rna-binding protein
THMIRHAM_15130	COG0285	dihydrofolate synthase activity
THMIRHAM_15140	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
THMIRHAM_15150	COG0159	tryptophan synthase activity
THMIRHAM_15170	COG0135	phosphoribosylanthranilate isomerase activity
THMIRHAM_15180	COG0101	tRNA pseudouridine synthase activity
THMIRHAM_15190	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
THMIRHAM_15220	COG0473	3-isopropylmalate dehydrogenase activity
THMIRHAM_15230	COG0066	3-isopropylmalate dehydratase activity
THMIRHAM_15240	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
THMIRHAM_15250	COG0602	queuosine metabolic process
THMIRHAM_15260	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
THMIRHAM_15270	COG0803	Belongs to the bacterial solute-binding protein 9 family
THMIRHAM_15280	COG1121	(ABC) transporter
THMIRHAM_15290	COG1108	ABC-type Mn2 Zn2 transport systems permease components
THMIRHAM_15290	COG1321	iron dependent repressor
THMIRHAM_15300	COG1108	ABC-type Mn2 Zn2 transport systems permease components
THMIRHAM_15310	COG0561	phosphatase activity
THMIRHAM_15330	COG2203	Gaf domain
THMIRHAM_15330	COG4251	negative regulation of phosphorylation
THMIRHAM_15330	COG5001	Diguanylate cyclase
THMIRHAM_15330	COG3706	GGDEF domain
THMIRHAM_15360	COG0659	secondary active sulfate transmembrane transporter activity
THMIRHAM_15370	COG3123	guanosine phosphorylase activity
THMIRHAM_15390	COG2814	Major facilitator Superfamily
THMIRHAM_15400	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
THMIRHAM_15440	COG2353	YceI-like domain
THMIRHAM_15450	COG3038	cytochrome b561
THMIRHAM_15460	COG3338	carbonate dehydratase activity
THMIRHAM_15470	COG2890	protein-(glutamine-N5) methyltransferase activity
THMIRHAM_15480	COG0521	Mo-molybdopterin cofactor biosynthetic process
THMIRHAM_15490	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
THMIRHAM_15530	COG4181	ATPase activity
THMIRHAM_15570	COG0776	regulation of translation
THMIRHAM_15580	COG0072	phenylalanine-tRNA ligase activity
THMIRHAM_15580	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
THMIRHAM_15590	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
THMIRHAM_15600	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
THMIRHAM_15610	COG0291	Belongs to the bacterial ribosomal protein bL35 family
THMIRHAM_15620	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
THMIRHAM_15630	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
THMIRHAM_15710	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
THMIRHAM_15750	COG0446	pyridine nucleotide-disulphide oxidoreductase
THMIRHAM_15760	COG2863	cytochrome
THMIRHAM_15770	COG2814	Major facilitator Superfamily
THMIRHAM_15810	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
THMIRHAM_15820	COG2223	nitrite transmembrane transporter activity
THMIRHAM_15830	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
THMIRHAM_15850	COG0028	Belongs to the TPP enzyme family
THMIRHAM_15860	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
THMIRHAM_15870	COG0501	Belongs to the peptidase M48B family
THMIRHAM_15880	COG2154	pterin-4-alpha-carbinolamine dehydratase
THMIRHAM_15890	COG1162	GTPase activity
THMIRHAM_15930	COG1160	GTP binding
THMIRHAM_15940	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
THMIRHAM_15960	COG0124	histidyl-tRNA synthetase
THMIRHAM_15980	COG0820	rRNA (adenine-C2-)-methyltransferase activity
THMIRHAM_15990	COG0105	UTP biosynthetic process
THMIRHAM_16000	COG0316	Belongs to the HesB IscA family
THMIRHAM_16050	COG0456	acetyltransferase
THMIRHAM_16070	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
THMIRHAM_16080	COG1183	phosphatidylcholine synthase activity
THMIRHAM_16090	COG2210	Belongs to the sulfur carrier protein TusA family
THMIRHAM_16110	COG4783	chaperone-mediated protein folding
THMIRHAM_16150	COG3258	Cytochrome c
THMIRHAM_16160	COG2801	Transposase and inactivated derivatives
THMIRHAM_16190	COG0129	dihydroxy-acid dehydratase activity
THMIRHAM_16200	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
THMIRHAM_16200	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
THMIRHAM_16210	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
THMIRHAM_16220	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
THMIRHAM_16230	COG0367	asparagine synthase
THMIRHAM_16260	COG0237	dephospho-CoA kinase activity
THMIRHAM_16270	COG0352	thiamine-phosphate diphosphorylase activity
THMIRHAM_16290	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
THMIRHAM_16300	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
THMIRHAM_16310	COG0653	protein targeting
THMIRHAM_16330	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
THMIRHAM_16350	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
THMIRHAM_16360	COG1181	Belongs to the D-alanine--D-alanine ligase family
THMIRHAM_16370	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
THMIRHAM_16390	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
THMIRHAM_16400	COG0719	Fe-S assembly protein
THMIRHAM_16410	COG0396	ATPase activity
THMIRHAM_16420	COG0719	Fe-S assembly protein
THMIRHAM_16450	COG1121	(ABC) transporter
THMIRHAM_16460	COG1108	ABC-type Mn2 Zn2 transport systems permease components
THMIRHAM_16470	COG0840	transmembrane signaling receptor activity
THMIRHAM_16490	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
THMIRHAM_16500	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
THMIRHAM_16530	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
THMIRHAM_16540	COG0772	Belongs to the SEDS family
THMIRHAM_16550	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
THMIRHAM_16560	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
THMIRHAM_16570	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
THMIRHAM_16580	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
THMIRHAM_16610	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
THMIRHAM_16620	COG0275	rRNA processing
THMIRHAM_16630	COG2001	Belongs to the MraZ family
THMIRHAM_16670	COG0742	ribosomal rna small subunit methyltransferase
THMIRHAM_16680	COG0745	RESPONSE REGULATOR receiver
THMIRHAM_16690	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
THMIRHAM_16700	COG3107	peptidoglycan biosynthetic process
THMIRHAM_16710	COG0792	nuclease activity
THMIRHAM_16720	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
THMIRHAM_16720	COG0574	Belongs to the PEP-utilizing enzyme family
THMIRHAM_16740	COG1074	ATP-dependent DNA helicase activity
THMIRHAM_16760	COG1714	RDD family
THMIRHAM_16810	COG2176	DNA-directed DNA polymerase activity
THMIRHAM_16860	COG0501	Belongs to the peptidase M48B family
THMIRHAM_16870	COG1704	LemA family
THMIRHAM_16900	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
THMIRHAM_16920	COG1304	FMN binding
THMIRHAM_16930	COG3425	synthase
THMIRHAM_16970	COG2969	positive regulation of protein catabolic process
THMIRHAM_16980	COG0625	glutathione transferase activity
THMIRHAM_16990	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
THMIRHAM_17000	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
THMIRHAM_17010	COG1509	lysine 2,3-aminomutase activity
THMIRHAM_17040	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
THMIRHAM_17100	COG0463	Glycosyl transferase, family 2
THMIRHAM_17130	COG1322	Protein conserved in bacteria
THMIRHAM_17170	COG1459	type II secretion system
THMIRHAM_17180	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
THMIRHAM_17210	COG3409	Peptidoglycan-binding domain 1 protein
THMIRHAM_17210	COG3267	Type II secretory pathway component ExeA
THMIRHAM_17240	COG0424	maF-like protein
THMIRHAM_17260	COG0247	lactate metabolic process
THMIRHAM_17260	COG0277	FAD linked oxidase domain protein
THMIRHAM_17290	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
THMIRHAM_17300	COG3307	-O-antigen
THMIRHAM_17350	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
THMIRHAM_17360	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
THMIRHAM_17370	COG2194	sulfuric ester hydrolase activity
THMIRHAM_17390	COG1132	(ABC) transporter
THMIRHAM_17400	COG1560	Kdo2-lipid A biosynthetic process
THMIRHAM_17440	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
THMIRHAM_17450	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
THMIRHAM_17460	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
THMIRHAM_17470	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
THMIRHAM_17480	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
THMIRHAM_17550	COG4964	Belongs to the GSP D family
THMIRHAM_17590	COG2963	transposase activity
THMIRHAM_17600	COG2801	Transposase and inactivated derivatives
THMIRHAM_17620	COG2963	transposase activity
THMIRHAM_17630	COG2801	Transposase and inactivated derivatives
THMIRHAM_17670	COG2945	thiolester hydrolase activity
THMIRHAM_17680	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
THMIRHAM_17690	COG3439	Domain of unknown function DUF302
THMIRHAM_17720	COG3030	protein affecting phage T7 exclusion by the F plasmid
THMIRHAM_17730	COG4232	protein-disulfide reductase activity
THMIRHAM_17740	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
THMIRHAM_17750	COG0511	ligase activity, forming carbon-carbon bonds
THMIRHAM_17760	COG0439	Biotin carboxylase
THMIRHAM_17770	COG2264	protein methyltransferase activity
THMIRHAM_17780	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
THMIRHAM_17800	COG0138	bifunctional purine biosynthesis protein purh
THMIRHAM_17820	COG0151	Belongs to the GarS family
THMIRHAM_17840	COG0542	response to heat
THMIRHAM_17870	COG3706	GGDEF domain
THMIRHAM_17880	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
THMIRHAM_17880	COG0116	Belongs to the methyltransferase superfamily
THMIRHAM_17890	COG2951	lytic endotransglycosylase activity
THMIRHAM_17930	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
THMIRHAM_17940	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
THMIRHAM_17950	COG0196	riboflavin kinase activity
THMIRHAM_17970	COG0028	Belongs to the TPP enzyme family
THMIRHAM_17990	COG2814	Major facilitator Superfamily
THMIRHAM_18000	COG0268	Binds directly to 16S ribosomal RNA
THMIRHAM_18010	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
THMIRHAM_18020	COG0799	negative regulation of ribosome biogenesis
THMIRHAM_18030	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
THMIRHAM_18040	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
THMIRHAM_18070	COG0495	leucyl-tRNA aminoacylation
THMIRHAM_18090	COG0815	Transfers the fatty acyl group on membrane lipoproteins
THMIRHAM_18100	COG4535	Mg2 and Co2 transporter CorC
THMIRHAM_18110	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
THMIRHAM_18120	COG1702	phosphate starvation-inducible protein PhoH
THMIRHAM_18130	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
THMIRHAM_18220	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
THMIRHAM_18230	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
THMIRHAM_18280	COG3706	GGDEF domain
THMIRHAM_18290	COG1858	cytochrome C peroxidase
THMIRHAM_18300	COG5001	Diguanylate cyclase
THMIRHAM_18300	COG3300	MHYT domain
THMIRHAM_18310	COG0523	cobalamin synthesis protein
THMIRHAM_18320	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
THMIRHAM_18350	COG0494	nUDIX hydrolase
THMIRHAM_18360	COG1011	Hydrolase
THMIRHAM_18370	COG0488	(ABC) transporter
THMIRHAM_18380	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
THMIRHAM_18390	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
THMIRHAM_18400	COG0500	methyltransferase
THMIRHAM_18420	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
THMIRHAM_18440	COG0123	including yeast histone deacetylase and acetoin utilization protein
THMIRHAM_18460	COG1595	DNA-templated transcription, initiation
THMIRHAM_18480	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
THMIRHAM_18490	COG1295	ribonuclease BN
THMIRHAM_18510	COG2801	Transposase and inactivated derivatives
THMIRHAM_18540	COG3220	belongs to the UPF0276 family
THMIRHAM_18560	COG0693	protein deglycase activity
THMIRHAM_18570	COG0793	Belongs to the peptidase S41A family
THMIRHAM_18580	COG0640	Transcriptional regulator
THMIRHAM_18640	COG1610	YqeY-like protein
THMIRHAM_18650	COG0828	Belongs to the bacterial ribosomal protein bS21 family
THMIRHAM_18660	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
THMIRHAM_18670	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
THMIRHAM_18680	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
THMIRHAM_18720	COG1968	undecaprenyl-diphosphatase activity
THMIRHAM_18730	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
THMIRHAM_18730	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
THMIRHAM_18740	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
THMIRHAM_18750	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
THMIRHAM_18760	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
THMIRHAM_18760	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
THMIRHAM_18780	COG0356	it plays a direct role in the translocation of protons across the membrane
THMIRHAM_18810	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
THMIRHAM_18830	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
THMIRHAM_18850	COG5002	protein histidine kinase activity
THMIRHAM_18850	COG5001	Diguanylate cyclase
THMIRHAM_18860	COG4943	cyclic-guanylate-specific phosphodiesterase activity
THMIRHAM_18870	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
THMIRHAM_18880	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
THMIRHAM_18890	COG1385	rRNA (uridine-N3-)-methyltransferase activity
THMIRHAM_18900	COG3706	GGDEF domain
THMIRHAM_18920	COG0189	ligase activity
THMIRHAM_18930	COG0840	transmembrane signaling receptor activity
THMIRHAM_18930	COG0840	transmembrane signaling receptor activity
THMIRHAM_18950	COG1678	Uncharacterized ACR, COG1678
THMIRHAM_18960	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
THMIRHAM_18970	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
THMIRHAM_18980	COG0540	Belongs to the ATCase OTCase family
THMIRHAM_18990	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
THMIRHAM_19020	COG2326	polyphosphate kinase activity
THMIRHAM_19080	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
THMIRHAM_19090	COG2813	Specifically methylates the guanine in position
THMIRHAM_19090	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
THMIRHAM_19160	COG0748	coenzyme F420 binding
THMIRHAM_19190	COG0019	diaminopimelate decarboxylase activity
THMIRHAM_19210	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
THMIRHAM_19220	COG0509	glycine decarboxylation via glycine cleavage system
THMIRHAM_19300	COG1132	(ABC) transporter
THMIRHAM_19320	COG2205	protein histidine kinase activity
THMIRHAM_19350	COG0457	Tetratricopeptide repeat
THMIRHAM_19360	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
THMIRHAM_19380	COG0579	oxidoreductase
THMIRHAM_19390	COG0523	cobalamin synthesis protein
THMIRHAM_19400	COG1469	GTP cyclohydrolase I activity
THMIRHAM_19420	COG0628	permease
THMIRHAM_19430	COG1611	Belongs to the LOG family
THMIRHAM_19440	COG0513	Belongs to the DEAD box helicase family
THMIRHAM_19460	COG1012	belongs to the aldehyde dehydrogenase family
THMIRHAM_19470	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
THMIRHAM_19480	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
THMIRHAM_19500	COG1716	ATPase activity
THMIRHAM_19500	COG5001	Diguanylate cyclase
THMIRHAM_19510	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
THMIRHAM_19540	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
THMIRHAM_19570	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
THMIRHAM_19580	COG2062	phosphohistidine phosphatase, SixA
THMIRHAM_19610	COG0668	transmembrane transport
THMIRHAM_19620	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
THMIRHAM_19630	COG1666	GTP binding
THMIRHAM_19640	COG0436	Aminotransferase
THMIRHAM_19650	COG0756	dUTP diphosphatase activity
THMIRHAM_19660	COG1115	amino acid carrier protein
THMIRHAM_19670	COG3706	GGDEF domain
THMIRHAM_19680	COG1760	l-serine dehydratase
THMIRHAM_19690	COG3287	FIST C domain
THMIRHAM_19690	COG2200	EAL domain
THMIRHAM_19690	COG2199	diguanylate cyclase activity
THMIRHAM_19700	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
THMIRHAM_19720	COG3038	cytochrome b561
THMIRHAM_19730	COG0446	pyridine nucleotide-disulphide oxidoreductase
THMIRHAM_19760	COG2003	Belongs to the UPF0758 family
THMIRHAM_19770	COG0446	pyridine nucleotide-disulphide oxidoreductase
THMIRHAM_19790	COG3264	Mechanosensitive ion channel
THMIRHAM_19790	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
THMIRHAM_19810	COG2010	Cytochrome c
THMIRHAM_19820	COG0227	Belongs to the bacterial ribosomal protein bL28 family
THMIRHAM_19830	COG0267	Belongs to the bacterial ribosomal protein bL33 family
THMIRHAM_19840	COG3706	GGDEF domain
THMIRHAM_19860	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
THMIRHAM_19870	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
THMIRHAM_19880	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
THMIRHAM_19940	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
THMIRHAM_19950	COG3338	carbonate dehydratase activity
THMIRHAM_19960	COG0742	ribosomal rna small subunit methyltransferase
THMIRHAM_19980	COG2996	Protein conserved in bacteria
THMIRHAM_20010	COG0778	Nitroreductase
THMIRHAM_20020	COG0612	Peptidase, M16
THMIRHAM_20030	COG0612	Peptidase, M16
THMIRHAM_20040	COG0552	protein localization to endoplasmic reticulum
THMIRHAM_20080	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
THMIRHAM_20090	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
THMIRHAM_20100	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
THMIRHAM_20110	COG0167	dihydroorotate dehydrogenase activity
THMIRHAM_20120	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
THMIRHAM_20130	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
THMIRHAM_20140	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
THMIRHAM_20150	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
THMIRHAM_20170	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
THMIRHAM_20190	COG3021	interspecies interaction between organisms
THMIRHAM_20200	COG0070	glutamate synthase
THMIRHAM_20200	COG0069	glutamate synthase activity
THMIRHAM_20200	COG0067	glutamate synthase
THMIRHAM_20210	COG0493	'glutamate synthase
THMIRHAM_20280	COG1028	Short-chain dehydrogenase reductase Sdr
THMIRHAM_20300	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
THMIRHAM_20310	COG0281	malic enzyme
THMIRHAM_20330	COG0616	signal peptide processing
THMIRHAM_20340	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
THMIRHAM_20350	COG3706	GGDEF domain
THMIRHAM_20360	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
THMIRHAM_20370	COG0840	transmembrane signaling receptor activity
THMIRHAM_20370	COG0840	transmembrane signaling receptor activity
THMIRHAM_20410	COG2205	protein histidine kinase activity
THMIRHAM_20410	COG0784	Response regulator, receiver
THMIRHAM_20440	COG4771	TonB-dependent receptor
THMIRHAM_20460	COG0033	Phosphoglucomutase
THMIRHAM_20480	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
THMIRHAM_20510	COG0189	ligase activity
THMIRHAM_20540	COG3706	GGDEF domain
THMIRHAM_20550	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
THMIRHAM_20590	COG0484	heat shock protein binding
THMIRHAM_20620	COG0390	transport system, permease component
THMIRHAM_20630	COG4619	ABC transporter
THMIRHAM_20670	COG0254	rRNA binding
THMIRHAM_20690	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
THMIRHAM_20710	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
THMIRHAM_20720	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
THMIRHAM_20730	COG1194	a g-specific adenine glycosylase
THMIRHAM_20740	COG0220	tRNA (guanine-N7-)-methyltransferase activity
THMIRHAM_20760	COG0635	Involved in the biosynthesis of porphyrin-containing compound
THMIRHAM_20780	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
THMIRHAM_20800	COG1561	YicC-like family, N-terminal region
THMIRHAM_20830	COG3001	Fructosamine kinase
THMIRHAM_20840	COG0563	adenylate kinase activity
THMIRHAM_20850	COG2814	Major facilitator Superfamily
THMIRHAM_20920	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
THMIRHAM_20930	COG3267	Type II secretory pathway component ExeA
THMIRHAM_20930	COG3409	Peptidoglycan-binding domain 1 protein
THMIRHAM_20950	COG1450	Type ii and iii secretion system protein
THMIRHAM_21100	COG2165	general secretion pathway protein
THMIRHAM_21130	COG1459	type II secretion system
THMIRHAM_21170	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
THMIRHAM_21170	COG0662	Cupin 2, conserved barrel domain protein
THMIRHAM_21210	COG1090	epimerase
THMIRHAM_21220	COG0415	Belongs to the DNA photolyase family
THMIRHAM_21270	COG0259	pyridoxamine-phosphate oxidase activity
THMIRHAM_21320	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
THMIRHAM_21340	COG1522	sequence-specific DNA binding
THMIRHAM_21360	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
THMIRHAM_21380	COG1366	Belongs to the anti-sigma-factor antagonist family
THMIRHAM_21400	COG0415	Belongs to the DNA photolyase family
THMIRHAM_21430	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
THMIRHAM_21460	COG0300	oxidoreductase activity
THMIRHAM_21490	COG0583	DNA-binding transcription factor activity
THMIRHAM_21500	COG0583	DNA-binding transcription factor activity
THMIRHAM_21510	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
THMIRHAM_21540	COG2154	pterin-4-alpha-carbinolamine dehydratase
THMIRHAM_21560	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
THMIRHAM_21570	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
THMIRHAM_21580	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
THMIRHAM_21590	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
THMIRHAM_21650	COG1850	ribulose-bisphosphate carboxylase activity
THMIRHAM_21660	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
THMIRHAM_21670	COG3002	Belongs to the UPF0753 family
THMIRHAM_21690	COG0784	Response regulator, receiver
THMIRHAM_21690	COG2205	protein histidine kinase activity
THMIRHAM_21700	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
THMIRHAM_21710	COG3842	ATPase activity
THMIRHAM_21720	COG1176	ABC-type spermidine putrescine transport system, permease component I
THMIRHAM_21730	COG1177	transmembrane transport
THMIRHAM_21750	COG0561	phosphatase activity
THMIRHAM_21750	COG3100	YcgL domain-containing protein
THMIRHAM_21760	COG0438	transferase activity, transferring glycosyl groups
THMIRHAM_21770	COG0363	glucosamine-6-phosphate deaminase activity
THMIRHAM_21780	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
THMIRHAM_21790	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
THMIRHAM_21800	COG0366	Alpha amylase catalytic
THMIRHAM_21810	COG1215	transferase activity, transferring glycosyl groups
THMIRHAM_21820	COG3769	mannosylglycerate metabolic process
THMIRHAM_21840	COG1854	S-ribosylhomocysteine lyase activity
THMIRHAM_21850	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
THMIRHAM_21860	COG3647	Membrane
THMIRHAM_21880	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
THMIRHAM_21950	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
THMIRHAM_21970	COG0676	glucose-6-phosphate 1-epimerase activity
THMIRHAM_21980	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
THMIRHAM_21990	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
THMIRHAM_22000	COG0194	GDP metabolic process
THMIRHAM_22010	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
THMIRHAM_22020	COG1454	alcohol dehydrogenase
THMIRHAM_22030	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
THMIRHAM_22040	COG1519	Transferase
THMIRHAM_22050	COG1758	RNA polymerase activity
THMIRHAM_22060	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
THMIRHAM_22110	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
THMIRHAM_22120	COG3161	chorismate lyase activity
THMIRHAM_22160	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
THMIRHAM_22180	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
THMIRHAM_22190	COG0355	proton-transporting ATP synthase activity, rotational mechanism
THMIRHAM_22200	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
THMIRHAM_22210	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
THMIRHAM_22220	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
THMIRHAM_22230	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
THMIRHAM_22240	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
THMIRHAM_22250	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
THMIRHAM_22260	COG0356	it plays a direct role in the translocation of protons across the membrane
THMIRHAM_22300	COG1192	Involved in chromosome partitioning
THMIRHAM_22310	COG0357	Ribosomal RNA small subunit methyltransferase G
THMIRHAM_22320	COG0445	tRNA wobble uridine modification
THMIRHAM_22360	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
THMIRHAM_22360	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
THMIRHAM_22410	COG1739	Uncharacterized protein family UPF0029
THMIRHAM_22450	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
THMIRHAM_22470	COG0706	membrane insertase activity
THMIRHAM_22480	COG0594	ribonuclease P activity
THMIRHAM_22490	COG0230	Belongs to the bacterial ribosomal protein bL34 family
THMIRHAM_22500	COG1238	metal cluster binding
THMIRHAM_22510	COG0730	response to heat