locus-tag	class	description
THMIRHAS_00010	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
THMIRHAS_00020	COG0592	DNA-directed DNA polymerase activity
THMIRHAS_00040	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
THMIRHAS_00060	COG0187	DNA topoisomerase II activity
THMIRHAS_00110	COG4372	Transposase
THMIRHAS_00120	COG3436	PFAM IS66 Orf2 family protein
THMIRHAS_00160	COG2433	Pfam Transposase IS66
THMIRHAS_00170	COG0363	glucosamine-6-phosphate deaminase activity
THMIRHAS_00180	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
THMIRHAS_00190	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
THMIRHAS_00210	COG1595	DNA-templated transcription, initiation
THMIRHAS_00300	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
THMIRHAS_00320	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
THMIRHAS_00330	COG2853	Lipoprotein
THMIRHAS_00350	COG0778	Nitroreductase
THMIRHAS_00380	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
THMIRHAS_00390	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
THMIRHAS_00400	COG1333	cytochrome c biogenesis protein
THMIRHAS_00410	COG0218	Necessary for normal cell division and for the maintenance of normal septation
THMIRHAS_00430	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
THMIRHAS_00430	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
THMIRHAS_00440	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
THMIRHAS_00450	COG0009	L-threonylcarbamoyladenylate synthase
THMIRHAS_00480	COG0408	coproporphyrinogen oxidase activity
THMIRHAS_00490	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
THMIRHAS_00530	COG1320	monovalent cation:proton antiporter activity
THMIRHAS_00540	COG2212	antiporter activity
THMIRHAS_00560	COG0651	ATP synthesis coupled electron transport
THMIRHAS_00570	COG1006	Multisubunit Na H antiporter MnhC subunit
THMIRHAS_00580	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
THMIRHAS_00580	COG2111	Na H antiporter
THMIRHAS_00600	COG5001	Diguanylate cyclase
THMIRHAS_00610	COG4372	Transposase
THMIRHAS_00620	COG2433	Pfam Transposase IS66
THMIRHAS_00640	COG2801	Transposase and inactivated derivatives
THMIRHAS_00650	COG2433	Pfam Transposase IS66
THMIRHAS_00660	COG2433	Pfam Transposase IS66
THMIRHAS_00700	COG1283	sodium-dependent phosphate transmembrane transporter activity
THMIRHAS_00720	COG1136	(ABC) transporter
THMIRHAS_00770	COG0339	signal peptide processing
THMIRHAS_00780	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
THMIRHAS_00820	COG5001	Diguanylate cyclase
THMIRHAS_00850	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
THMIRHAS_00880	COG3038	cytochrome b561
THMIRHAS_00910	COG0204	Acyl-transferase
THMIRHAS_00910	COG0318	PFAM AMP-dependent synthetase and ligase
THMIRHAS_00920	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
THMIRHAS_00920	COG0045	succinate-CoA ligase (ADP-forming) activity
THMIRHAS_00920	COG1042	CoA-binding domain protein
THMIRHAS_00930	COG0123	including yeast histone deacetylase and acetoin utilization protein
THMIRHAS_01000	COG0714	Associated with various cellular activities
THMIRHAS_01030	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
THMIRHAS_01050	COG2226	methyltransferase
THMIRHAS_01060	COG0500	methyltransferase
THMIRHAS_01080	COG0714	Associated with various cellular activities
THMIRHAS_01140	COG3118	belongs to the thioredoxin family
THMIRHAS_01200	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
THMIRHAS_01210	COG0165	Argininosuccinate lyase
THMIRHAS_01230	COG0181	hydroxymethylbilane synthase activity
THMIRHAS_01280	COG2829	1-acyl-2-lysophosphatidylserine acylhydrolase activity
THMIRHAS_01300	COG0708	Exodeoxyribonuclease III
THMIRHAS_01320	COG0788	formyltetrahydrofolate deformylase activity
THMIRHAS_01340	COG1444	tRNA N-acetyltransferase activity
THMIRHAS_01350	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
THMIRHAS_01360	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
THMIRHAS_01360	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
THMIRHAS_01380	COG0351	phosphomethylpyrimidine kinase
THMIRHAS_01400	COG2081	HI0933 family
THMIRHAS_01460	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
THMIRHAS_01490	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
THMIRHAS_01500	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
THMIRHAS_01560	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
THMIRHAS_01570	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
THMIRHAS_01580	COG0314	molybdopterin synthase activity
THMIRHAS_01590	COG0303	'Molybdopterin
THMIRHAS_01610	COG0315	cyclic pyranopterin monophosphate synthase activity
THMIRHAS_01620	COG5002	protein histidine kinase activity
THMIRHAS_01620	COG5001	Diguanylate cyclase
THMIRHAS_01650	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
THMIRHAS_01690	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
THMIRHAS_01700	COG2226	methyltransferase
THMIRHAS_01710	COG0596	Alpha beta hydrolase
THMIRHAS_01730	COG1115	amino acid carrier protein
THMIRHAS_01760	COG2308	Evidence 4 Homologs of previously reported genes of
THMIRHAS_01780	COG0156	8-amino-7-oxononanoate synthase activity
THMIRHAS_01790	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
THMIRHAS_01800	COG1040	competence protein
THMIRHAS_01810	COG1230	cation diffusion facilitator family transporter
THMIRHAS_01830	COG1331	Highly conserved protein containing a thioredoxin domain
THMIRHAS_01850	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
THMIRHAS_01860	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
THMIRHAS_01870	COG0537	adenosine 5'-monophosphoramidase activity
THMIRHAS_01880	COG0140	phosphoribosyl-ATP diphosphatase activity
THMIRHAS_01890	COG0107	imidazoleglycerol-phosphate synthase activity
THMIRHAS_01900	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
THMIRHAS_01910	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
THMIRHAS_01920	COG0131	Imidazoleglycerol-phosphate dehydratase
THMIRHAS_01930	COG3278	Belongs to the heme-copper respiratory oxidase family
THMIRHAS_01960	COG2010	Cytochrome c
THMIRHAS_01980	COG0348	domain, Protein
THMIRHAS_02000	COG2217	Heavy metal translocating P-type atpase
THMIRHAS_02060	COG1490	D-aminoacyl-tRNA deacylase activity
THMIRHAS_02100	COG2391	methyltransferase activity
THMIRHAS_02130	COG3719	Belongs to the RNase T2 family
THMIRHAS_02220	COG0513	Belongs to the DEAD box helicase family
THMIRHAS_02230	COG4628	conserved protein (DUF2132)
THMIRHAS_02250	COG0840	transmembrane signaling receptor activity
THMIRHAS_02250	COG0840	transmembrane signaling receptor activity
THMIRHAS_02260	COG0515	serine threonine protein kinase
THMIRHAS_02270	COG1708	protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity
THMIRHAS_02280	COG0646	methionine synthase
THMIRHAS_02280	COG1410	methionine synthase
THMIRHAS_02310	COG1410	methionine synthase
THMIRHAS_02310	COG0646	methionine synthase
THMIRHAS_02330	COG3706	GGDEF domain
THMIRHAS_02340	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
THMIRHAS_02350	COG0730	response to heat
THMIRHAS_02410	COG0037	tRNA processing
THMIRHAS_02440	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
THMIRHAS_02450	COG0569	domain protein
THMIRHAS_02460	COG2204	response regulator
THMIRHAS_02470	COG5000	phosphorelay sensor kinase activity
THMIRHAS_02490	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
THMIRHAS_02490	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
THMIRHAS_02500	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
THMIRHAS_02510	COG0242	peptide deformylase activity
THMIRHAS_02520	COG0758	DNA mediated transformation
THMIRHAS_02540	COG0018	arginyl-trna synthetase
THMIRHAS_02570	COG2960	long-chain fatty acid transporting porin activity
THMIRHAS_02580	COG0606	chelatase, subunit chli
THMIRHAS_02610	COG2197	response regulator
THMIRHAS_02660	COG0210	DNA helicase
THMIRHAS_02670	COG2813	Specifically methylates the guanine in position
THMIRHAS_02700	COG0585	pseudouridine synthase activity
THMIRHAS_02710	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
THMIRHAS_02730	COG3769	mannosylglycerate metabolic process
THMIRHAS_02740	COG1215	transferase activity, transferring glycosyl groups
THMIRHAS_02760	COG1929	Belongs to the glycerate kinase type-1 family
THMIRHAS_02800	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
THMIRHAS_02810	COG3100	YcgL domain-containing protein
THMIRHAS_02830	COG0617	tRNA 3'-terminal CCA addition
THMIRHAS_02890	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
THMIRHAS_02900	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
THMIRHAS_02910	COG0126	phosphoglycerate kinase activity
THMIRHAS_02940	COG1850	ribulose-bisphosphate carboxylase activity
THMIRHAS_03070	COG0583	DNA-binding transcription factor activity
THMIRHAS_03110	COG2433	Pfam Transposase IS66
THMIRHAS_03140	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
THMIRHAS_03160	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
THMIRHAS_03170	COG0546	phosphoglycolate phosphatase activity
THMIRHAS_03200	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
THMIRHAS_03210	COG2832	Protein of unknown function (DUF454)
THMIRHAS_03220	COG3550	peptidyl-serine autophosphorylation
THMIRHAS_03270	COG0134	indole-3-glycerol-phosphate synthase activity
THMIRHAS_03290	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
THMIRHAS_03300	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
THMIRHAS_03320	COG1765	OsmC-like protein
THMIRHAS_03340	COG0513	Belongs to the DEAD box helicase family
THMIRHAS_03350	COG1611	Belongs to the LOG family
THMIRHAS_03360	COG0628	permease
THMIRHAS_03420	COG1469	GTP cyclohydrolase I activity
THMIRHAS_03430	COG0523	cobalamin synthesis protein
THMIRHAS_03440	COG0579	oxidoreductase
THMIRHAS_03450	COG1090	epimerase
THMIRHAS_03480	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
THMIRHAS_03490	COG0739	heme binding
THMIRHAS_03500	COG0425	Belongs to the sulfur carrier protein TusA family
THMIRHAS_03520	COG0751	glycine-tRNA ligase activity
THMIRHAS_03530	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
THMIRHAS_03620	COG0840	transmembrane signaling receptor activity
THMIRHAS_03620	COG0840	transmembrane signaling receptor activity
THMIRHAS_03640	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
THMIRHAS_03660	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
THMIRHAS_03670	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
THMIRHAS_03690	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
THMIRHAS_03700	COG2890	protein-(glutamine-N5) methyltransferase activity
THMIRHAS_03710	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
THMIRHAS_03720	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
THMIRHAS_03750	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
THMIRHAS_03760	COG0193	aminoacyl-tRNA hydrolase activity
THMIRHAS_03770	COG0012	GTP binding
THMIRHAS_03930	COG2801	Transposase and inactivated derivatives
THMIRHAS_03960	COG3436	PFAM IS66 Orf2 family protein
THMIRHAS_03970	COG4372	Transposase
THMIRHAS_03990	COG2801	Transposase and inactivated derivatives
THMIRHAS_04040	COG1116	anion transmembrane transporter activity
THMIRHAS_04060	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
THMIRHAS_04100	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
THMIRHAS_04130	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
THMIRHAS_04150	COG0840	transmembrane signaling receptor activity
THMIRHAS_04220	COG1459	type II secretion system
THMIRHAS_04310	COG1404	Belongs to the peptidase S8 family
THMIRHAS_04350	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
THMIRHAS_04370	COG2226	methyltransferase
THMIRHAS_04390	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
THMIRHAS_04400	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
THMIRHAS_04430	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
THMIRHAS_04460	COG1519	Transferase
THMIRHAS_04470	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
THMIRHAS_04470	COG0517	IMP dehydrogenase activity
THMIRHAS_04490	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
THMIRHAS_04520	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
THMIRHAS_04530	COG0297	glycogen (starch) synthase activity
THMIRHAS_04540	COG0058	SHG alpha-glucan phosphorylase activity
THMIRHAS_04550	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
THMIRHAS_04620	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
THMIRHAS_04630	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
THMIRHAS_04670	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
THMIRHAS_04780	COG2003	Belongs to the UPF0758 family
THMIRHAS_04800	COG0582	viral genome integration into host DNA
THMIRHAS_04820	COG3657	addiction module killer protein
THMIRHAS_04850	COG0500	methyltransferase
THMIRHAS_04960	COG0582	viral genome integration into host DNA
THMIRHAS_05010	COG2433	Pfam Transposase IS66
THMIRHAS_05100	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
THMIRHAS_05130	COG0640	Transcriptional regulator
THMIRHAS_05140	COG0793	Belongs to the peptidase S41A family
THMIRHAS_05150	COG0693	protein deglycase activity
THMIRHAS_05170	COG1295	ribonuclease BN
THMIRHAS_05180	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
THMIRHAS_05190	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
THMIRHAS_05230	COG2026	Addiction module toxin, RelE StbE family
THMIRHAS_05240	COG3077	Addiction module antitoxin, RelB DinJ family
THMIRHAS_05300	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
THMIRHAS_05310	COG0659	secondary active sulfate transmembrane transporter activity
THMIRHAS_05320	COG0527	aspartate kinase activity
THMIRHAS_05330	COG2059	Chromate
THMIRHAS_05340	COG1917	Cupin 2, conserved barrel domain protein
THMIRHAS_05350	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
THMIRHAS_05360	COG0456	acetyltransferase
THMIRHAS_05380	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
THMIRHAS_05420	COG2205	protein histidine kinase activity
THMIRHAS_05420	COG0784	Response regulator, receiver
THMIRHAS_05430	COG0745	RESPONSE REGULATOR receiver
THMIRHAS_05440	COG5002	protein histidine kinase activity
THMIRHAS_05450	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
THMIRHAS_05460	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
THMIRHAS_05470	COG0500	methyltransferase
THMIRHAS_05480	COG1011	Hydrolase
THMIRHAS_05530	COG0831	urea catabolic process
THMIRHAS_05540	COG0832	Belongs to the urease beta subunit family
THMIRHAS_05550	COG0804	urea catabolic process
THMIRHAS_05560	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
THMIRHAS_05570	COG0830	nickel cation binding
THMIRHAS_05660	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
THMIRHAS_05670	COG0523	cobalamin synthesis protein
THMIRHAS_05780	COG1555	photosystem II stabilization
THMIRHAS_05790	COG1793	dna ligase
THMIRHAS_05800	COG0436	Aminotransferase
THMIRHAS_05810	COG0556	nucleotide-excision repair
THMIRHAS_05840	COG2866	Carboxypeptidase
THMIRHAS_05880	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
THMIRHAS_05890	COG0795	lipopolysaccharide-transporting ATPase activity
THMIRHAS_05900	COG0795	lipopolysaccharide-transporting ATPase activity
THMIRHAS_05910	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
THMIRHAS_05920	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
THMIRHAS_05950	COG1210	Utp--glucose-1-phosphate uridylyltransferase
THMIRHAS_05960	COG3437	response regulator, receiver
THMIRHAS_06060	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
THMIRHAS_06090	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
THMIRHAS_06100	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
THMIRHAS_06110	COG1862	Preprotein translocase
THMIRHAS_06120	COG0343	queuine tRNA-ribosyltransferase activity
THMIRHAS_06130	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
THMIRHAS_06170	COG4372	Transposase
THMIRHAS_06240	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
THMIRHAS_06300	COG1596	polysaccharide export
THMIRHAS_06320	COG4464	protein tyrosine phosphatase activity
THMIRHAS_06340	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
THMIRHAS_06380	COG4804	nuclease activity
THMIRHAS_06400	COG2244	polysaccharide biosynthetic process
THMIRHAS_06410	COG1216	Glycosyl transferase, family 2
THMIRHAS_06410	COG1442	glycosyl transferase family 8
THMIRHAS_06420	COG0463	Glycosyl transferase, family 2
THMIRHAS_06440	COG0438	transferase activity, transferring glycosyl groups
THMIRHAS_06450	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
THMIRHAS_06460	COG0438	transferase activity, transferring glycosyl groups
THMIRHAS_06480	COG2755	lipolytic protein G-D-S-L family
THMIRHAS_06480	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
THMIRHAS_06500	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
THMIRHAS_06530	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
THMIRHAS_06560	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
THMIRHAS_06580	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
THMIRHAS_06630	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
THMIRHAS_06650	COG2239	Acts as a magnesium transporter
THMIRHAS_06670	COG1137	ATPase activity
THMIRHAS_06730	COG1127	ABC transporter
THMIRHAS_06740	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
THMIRHAS_06750	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
THMIRHAS_06780	COG1131	(ABC) transporter
THMIRHAS_06790	COG0842	Transport permease protein
THMIRHAS_06810	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
THMIRHAS_06820	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
THMIRHAS_06830	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
THMIRHAS_06840	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
THMIRHAS_06850	COG0723	plastoquinol--plastocyanin reductase activity
THMIRHAS_06860	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
THMIRHAS_06870	COG2857	Cytochrome c1
THMIRHAS_06880	COG0069	glutamate synthase activity
THMIRHAS_06890	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
THMIRHAS_06930	COG0483	inositol monophosphate 1-phosphatase activity
THMIRHAS_06940	COG4536	flavin adenine dinucleotide binding
THMIRHAS_06960	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
THMIRHAS_06970	COG0228	four-way junction DNA binding
THMIRHAS_06980	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
THMIRHAS_06990	COG0336	Belongs to the RNA methyltransferase TrmD family
THMIRHAS_07000	COG0335	large ribosomal subunit rRNA binding
THMIRHAS_07010	COG4974	Belongs to the 'phage' integrase family
THMIRHAS_07020	COG0784	Response regulator, receiver
THMIRHAS_07020	COG2205	protein histidine kinase activity
THMIRHAS_07040	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
THMIRHAS_07100	COG0525	valine-tRNA ligase activity
THMIRHAS_07110	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
THMIRHAS_07140	COG0004	ammonium transporteR
THMIRHAS_07150	COG0347	Belongs to the P(II) protein family
THMIRHAS_07170	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
THMIRHAS_07180	COG0174	glutamine synthetase
THMIRHAS_07200	COG0573	inorganic phosphate transmembrane transporter activity
THMIRHAS_07210	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
THMIRHAS_07220	COG0704	Plays a role in the regulation of phosphate uptake
THMIRHAS_07270	COG1858	cytochrome C peroxidase
THMIRHAS_07300	COG0306	phosphate transporter
THMIRHAS_07350	COG0271	Belongs to the BolA IbaG family
THMIRHAS_07370	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
THMIRHAS_07380	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
THMIRHAS_07390	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
THMIRHAS_07400	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
THMIRHAS_07410	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
THMIRHAS_07430	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
THMIRHAS_07440	COG0850	regulation of cytokinetic process
THMIRHAS_07450	COG2894	cell division
THMIRHAS_07460	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
THMIRHAS_07470	COG3022	response to hydroperoxide
THMIRHAS_07480	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
THMIRHAS_07550	COG3290	protein histidine kinase activity
THMIRHAS_07580	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
THMIRHAS_07590	COG0321	lipoyl(octanoyl) transferase activity
THMIRHAS_07600	COG2921	Belongs to the UPF0250 family
THMIRHAS_07610	COG1686	Belongs to the peptidase S11 family
THMIRHAS_07620	COG0772	Belongs to the SEDS family
THMIRHAS_07630	COG0768	penicillin binding
THMIRHAS_07650	COG1792	Involved in formation and maintenance of cell shape
THMIRHAS_07660	COG1077	Cell shape determining protein MreB Mrl
THMIRHAS_07670	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
THMIRHAS_07680	COG0154	amidase activity
THMIRHAS_07690	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
THMIRHAS_07720	COG0501	Belongs to the peptidase M48B family
THMIRHAS_07730	COG2166	iron-sulfur cluster assembly
THMIRHAS_07740	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
THMIRHAS_07760	COG0811	peptide transport
THMIRHAS_07790	COG4772	TonB-dependent receptor
THMIRHAS_07800	COG0560	Phosphoserine phosphatase
THMIRHAS_07850	COG0519	Catalyzes the synthesis of GMP from XMP
THMIRHAS_07850	COG0518	GMP synthase (glutamine-hydrolyzing) activity
THMIRHAS_07870	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
THMIRHAS_07880	COG0643	Histidine kinase
THMIRHAS_07880	COG2198	Histidine kinase
THMIRHAS_07910	COG0326	Molecular chaperone. Has ATPase activity
THMIRHAS_07920	COG5002	protein histidine kinase activity
THMIRHAS_07920	COG0784	Response regulator, receiver
THMIRHAS_07940	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
THMIRHAS_07980	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
THMIRHAS_08020	COG4942	peptidase
THMIRHAS_08070	COG4372	Transposase
THMIRHAS_08080	COG3436	PFAM IS66 Orf2 family protein
THMIRHAS_08120	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
THMIRHAS_08130	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
THMIRHAS_08140	COG2137	regulation of response to DNA damage stimulus
THMIRHAS_08150	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
THMIRHAS_08160	COG1546	Belongs to the CinA family
THMIRHAS_08170	COG0784	Response regulator, receiver
THMIRHAS_08170	COG4191	Histidine kinase
THMIRHAS_08180	COG3300	MHYT domain
THMIRHAS_08180	COG5001	Diguanylate cyclase
THMIRHAS_08220	COG4372	Transposase
THMIRHAS_08270	COG4372	Transposase
THMIRHAS_08310	COG4372	Transposase
THMIRHAS_08320	COG3436	PFAM IS66 Orf2 family protein
THMIRHAS_08350	COG4372	Transposase
THMIRHAS_08370	COG4999	Histidine kinase
THMIRHAS_08370	COG3437	response regulator, receiver
THMIRHAS_08370	COG2205	protein histidine kinase activity
THMIRHAS_08370	COG3850	Histidine kinase
THMIRHAS_08390	COG1484	DNA-dependent DNA replication
THMIRHAS_08430	COG4999	Histidine kinase
THMIRHAS_08430	COG3437	response regulator, receiver
THMIRHAS_08430	COG3850	Histidine kinase
THMIRHAS_08430	COG2205	protein histidine kinase activity
THMIRHAS_08450	COG0840	transmembrane signaling receptor activity
THMIRHAS_08470	COG1755	Isoprenylcysteine carboxyl methyltransferase
THMIRHAS_08480	COG0617	tRNA 3'-terminal CCA addition
THMIRHAS_08490	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
THMIRHAS_08500	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
THMIRHAS_08510	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
THMIRHAS_08520	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
THMIRHAS_08540	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
THMIRHAS_08550	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
THMIRHAS_08560	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
THMIRHAS_08570	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
THMIRHAS_08580	COG0301	tRNA thio-modification
THMIRHAS_08580	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
THMIRHAS_08590	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
THMIRHAS_08610	COG0557	exoribonuclease II activity
THMIRHAS_08650	COG2885	chlorophyll binding
THMIRHAS_08660	COG0308	aminopeptidase N
THMIRHAS_08760	COG0835	chemotaxis
THMIRHAS_08760	COG0784	Response regulator, receiver
THMIRHAS_08780	COG1815	bacterial-type flagellum-dependent cell motility
THMIRHAS_08800	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
THMIRHAS_08810	COG1749	Flagellar hook protein flgE
THMIRHAS_08820	COG4786	Flagellar basal body rod
THMIRHAS_08830	COG4786	Flagellar basal body rod
THMIRHAS_08840	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
THMIRHAS_08850	COG1706	bacterial-type flagellum-dependent cell motility
THMIRHAS_08880	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
THMIRHAS_08890	COG0741	lytic transglycosylase activity
THMIRHAS_08900	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
THMIRHAS_08910	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
THMIRHAS_08930	COG2089	acid synthase
THMIRHAS_08940	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
THMIRHAS_08970	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
THMIRHAS_08980	COG1083	cytidylyl-transferase
THMIRHAS_09000	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
THMIRHAS_09010	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
THMIRHAS_09050	COG1516	flagellar protein fliS
THMIRHAS_09080	COG3852	Histidine kinase
THMIRHAS_09100	COG1677	Flagellar hook-basal body complex protein FliE
THMIRHAS_09120	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
THMIRHAS_09180	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
THMIRHAS_09250	COG1987	bacterial-type flagellum assembly
THMIRHAS_09270	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
THMIRHAS_09280	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
THMIRHAS_09330	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
THMIRHAS_09340	COG0643	Histidine kinase
THMIRHAS_09340	COG0784	Response regulator, receiver
THMIRHAS_09340	COG2198	Histidine kinase
THMIRHAS_09350	COG0835	chemotaxis
THMIRHAS_09360	COG2257	FlhB HrpN YscU SpaS Family
THMIRHAS_09380	COG0745	RESPONSE REGULATOR receiver
THMIRHAS_09390	COG0835	chemotaxis
THMIRHAS_09420	COG2201	protein-glutamate methylesterase activity
THMIRHAS_09430	COG0840	transmembrane signaling receptor activity
THMIRHAS_09450	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
THMIRHAS_09470	COG0492	ferredoxin-NADP+ reductase activity
THMIRHAS_09480	COG1674	ftsk spoiiie
THMIRHAS_09500	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
THMIRHAS_09510	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
THMIRHAS_09520	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
THMIRHAS_09540	COG0582	viral genome integration into host DNA
THMIRHAS_09570	COG2205	protein histidine kinase activity
THMIRHAS_09580	COG0745	RESPONSE REGULATOR receiver
THMIRHAS_09620	COG2204	response regulator
THMIRHAS_09660	COG3106	COG3106 Predicted ATPase
THMIRHAS_09680	COG4771	TonB-dependent receptor
THMIRHAS_09730	COG1120	ATPase activity
THMIRHAS_09740	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
THMIRHAS_09790	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
THMIRHAS_09820	COG2197	response regulator
THMIRHAS_09830	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
THMIRHAS_09870	COG2433	Pfam Transposase IS66
THMIRHAS_09920	COG4372	Transposase
THMIRHAS_09940	COG2433	Pfam Transposase IS66
THMIRHAS_09970	COG2433	Pfam Transposase IS66
THMIRHAS_10000	COG4372	Transposase
THMIRHAS_10030	COG3436	PFAM IS66 Orf2 family protein
THMIRHAS_10040	COG4372	Transposase
THMIRHAS_10080	COG4372	Transposase
THMIRHAS_10090	COG3436	PFAM IS66 Orf2 family protein
THMIRHAS_10120	COG4372	Transposase
THMIRHAS_10140	COG2433	Pfam Transposase IS66
THMIRHAS_10190	COG0205	6-phosphofructokinase activity
THMIRHAS_10200	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
THMIRHAS_10210	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
THMIRHAS_10250	COG2433	Pfam Transposase IS66
THMIRHAS_10270	COG3101	peptidyl-lysine hydroxylation
THMIRHAS_10300	COG1643	Atp-dependent helicase
THMIRHAS_10320	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
THMIRHAS_10330	COG0352	thiamine-phosphate diphosphorylase activity
THMIRHAS_10340	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
THMIRHAS_10350	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
THMIRHAS_10390	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
THMIRHAS_10410	COG0232	Belongs to the dGTPase family. Type 2 subfamily
THMIRHAS_10430	COG0802	atpase or kinase
THMIRHAS_10440	COG0860	N-Acetylmuramoyl-L-alanine amidase
THMIRHAS_10450	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
THMIRHAS_10480	COG0006	proline dipeptidase activity
THMIRHAS_10490	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
THMIRHAS_10500	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
THMIRHAS_10510	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
THMIRHAS_10520	COG0583	DNA-binding transcription factor activity
THMIRHAS_10530	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
THMIRHAS_10550	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
THMIRHAS_10560	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
THMIRHAS_10610	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
THMIRHAS_10630	COG1177	transmembrane transport
THMIRHAS_10640	COG1176	ABC-type spermidine putrescine transport system, permease component I
THMIRHAS_10650	COG3842	ATPase activity
THMIRHAS_10660	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
THMIRHAS_10670	COG0493	'glutamate synthase
THMIRHAS_10670	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
THMIRHAS_10700	COG0488	(ABC) transporter
THMIRHAS_10710	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
THMIRHAS_10720	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
THMIRHAS_10730	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
THMIRHAS_10730	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
THMIRHAS_10760	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
THMIRHAS_10770	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
THMIRHAS_10780	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
THMIRHAS_10790	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
THMIRHAS_10810	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
THMIRHAS_10830	COG0720	synthase
THMIRHAS_10840	COG0142	geranyltranstransferase activity
THMIRHAS_10870	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
THMIRHAS_10880	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
THMIRHAS_10890	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
THMIRHAS_10900	COG0632	four-way junction helicase activity
THMIRHAS_10910	COG2255	four-way junction helicase activity
THMIRHAS_10920	COG0811	peptide transport
THMIRHAS_10950	COG0823	Involved in the tonB-independent uptake of proteins
THMIRHAS_10960	COG2885	chlorophyll binding
THMIRHAS_10980	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
THMIRHAS_11010	COG3852	Histidine kinase
THMIRHAS_11020	COG2204	response regulator
THMIRHAS_11040	COG1238	metal cluster binding
THMIRHAS_11060	COG0688	phosphatidylethanolamine metabolic process
THMIRHAS_11070	COG0137	argininosuccinate synthase activity
THMIRHAS_11080	COG1278	Cold shock
THMIRHAS_11100	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
THMIRHAS_11120	COG1301	dicarboxylic acid transport
THMIRHAS_11130	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
THMIRHAS_11160	COG0215	cysteine-tRNA ligase activity
THMIRHAS_11180	COG0741	lytic transglycosylase activity
THMIRHAS_11180	COG1388	LysM domain
THMIRHAS_11190	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
THMIRHAS_11200	COG2226	methyltransferase
THMIRHAS_11210	COG0328	RNA-DNA hybrid ribonuclease activity
THMIRHAS_11220	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
THMIRHAS_11230	COG1047	Peptidyl-prolyl cis-trans
THMIRHAS_11250	COG1643	Atp-dependent helicase
THMIRHAS_11320	COG0045	succinate-CoA ligase (ADP-forming) activity
THMIRHAS_11340	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
THMIRHAS_11340	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
THMIRHAS_11360	COG0564	pseudouridine synthase activity
THMIRHAS_11420	COG0716	FMN binding
THMIRHAS_11440	COG1051	belongs to the nudix hydrolase family
THMIRHAS_11460	COG0508	dehydrogenase complex catalyzes the overall conversion of
THMIRHAS_11470	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
THMIRHAS_11510	COG3530	Putative quorum-sensing-regulated virulence factor
THMIRHAS_11520	COG0686	Belongs to the AlaDH PNT family
THMIRHAS_11550	COG1902	pentaerythritol trinitrate reductase activity
THMIRHAS_11560	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
THMIRHAS_11580	COG0596	Alpha beta hydrolase
THMIRHAS_11600	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
THMIRHAS_11610	COG0513	Belongs to the DEAD box helicase family
THMIRHAS_11630	COG3122	Protein conserved in bacteria
THMIRHAS_11650	COG0513	Belongs to the DEAD box helicase family
THMIRHAS_11660	COG0488	(ABC) transporter
THMIRHAS_11700	COG1192	Involved in chromosome partitioning
THMIRHAS_11730	COG0545	Peptidyl-prolyl cis-trans isomerase
THMIRHAS_11760	COG3094	Invasion gene expression up-regulator, SirB
THMIRHAS_11800	COG0564	pseudouridine synthase activity
THMIRHAS_11810	COG2983	Belongs to the UPF0260 family
THMIRHAS_11830	COG1047	Peptidyl-prolyl cis-trans
THMIRHAS_11890	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
THMIRHAS_11940	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
THMIRHAS_11990	COG0840	transmembrane signaling receptor activity
THMIRHAS_12020	COG2954	triphosphatase activity
THMIRHAS_12050	COG0747	negative chemotaxis
THMIRHAS_12070	COG0601	transmembrane transport
THMIRHAS_12100	COG1472	Belongs to the glycosyl hydrolase 3 family
THMIRHAS_12110	COG0668	transmembrane transport
THMIRHAS_12130	COG0812	UDP-N-acetylmuramate dehydrogenase activity
THMIRHAS_12140	COG0733	neurotransmitter:sodium symporter activity
THMIRHAS_12190	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
THMIRHAS_12220	COG2022	thiamine diphosphate biosynthetic process
THMIRHAS_12270	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
THMIRHAS_12290	COG0446	pyridine nucleotide-disulphide oxidoreductase
THMIRHAS_12330	COG1136	(ABC) transporter
THMIRHAS_12340	COG0488	(ABC) transporter
THMIRHAS_12350	COG0616	signal peptide processing
THMIRHAS_12360	COG0322	excinuclease ABC activity
THMIRHAS_12590	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
THMIRHAS_12600	COG1393	Belongs to the ArsC family
THMIRHAS_12610	COG2171	N-acyltransferase activity
THMIRHAS_12630	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
THMIRHAS_12640	COG0024	Methionine aminopeptidase
THMIRHAS_12650	COG0052	Belongs to the universal ribosomal protein uS2 family
THMIRHAS_12660	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
THMIRHAS_12670	COG0528	UMP kinase activity
THMIRHAS_12680	COG0233	cytoplasmic translational termination
THMIRHAS_12700	COG0575	Belongs to the CDS family
THMIRHAS_12720	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
THMIRHAS_12740	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
THMIRHAS_12750	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
THMIRHAS_12760	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
THMIRHAS_12770	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
THMIRHAS_12780	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
THMIRHAS_12790	COG0835	chemotaxis
THMIRHAS_12790	COG0784	Response regulator, receiver
THMIRHAS_12830	COG1199	ATP-dependent helicase activity
THMIRHAS_12880	COG1944	ATP diphosphatase activity
THMIRHAS_12900	COG0825	malonyl-CoA metabolic process
THMIRHAS_12910	COG0037	tRNA processing
THMIRHAS_12920	COG0504	CTP synthase activity
THMIRHAS_12930	COG2877	3-deoxy-8-phosphooctulonate synthase activity
THMIRHAS_12940	COG0148	phosphopyruvate hydratase activity
THMIRHAS_12950	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
THMIRHAS_12970	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
THMIRHAS_12980	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
THMIRHAS_12990	COG1238	metal cluster binding
THMIRHAS_13020	COG0436	Aminotransferase
THMIRHAS_13050	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
THMIRHAS_13120	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
THMIRHAS_13140	COG1070	Carbohydrate kinase
THMIRHAS_13160	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
THMIRHAS_13170	COG3028	Belongs to the UPF0307 family
THMIRHAS_13200	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
THMIRHAS_13210	COG2350	Protein conserved in bacteria
THMIRHAS_13220	COG2917	probably involved in intracellular septation
THMIRHAS_13230	COG0613	PHP domain protein
THMIRHAS_13240	COG0009	L-threonylcarbamoyladenylate synthase
THMIRHAS_13250	COG1994	Peptidase M50
THMIRHAS_13260	COG1187	pseudouridine synthase activity
THMIRHAS_13330	COG1570	exodeoxyribonuclease VII activity
THMIRHAS_13340	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
THMIRHAS_13350	COG3706	GGDEF domain
THMIRHAS_13370	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
THMIRHAS_13380	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
THMIRHAS_13440	COG0745	RESPONSE REGULATOR receiver
THMIRHAS_13470	COG3012	SEC-C Motif Domain Protein
THMIRHAS_13480	COG0534	Mate efflux family protein
THMIRHAS_13500	COG0494	nUDIX hydrolase
THMIRHAS_13510	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
THMIRHAS_13530	COG0359	binds to the 23S rRNA
THMIRHAS_13550	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
THMIRHAS_13560	COG0360	Binds together with S18 to 16S ribosomal RNA
THMIRHAS_13570	COG0284	orotidine-5'-phosphate decarboxylase activity
THMIRHAS_13590	COG0776	regulation of translation
THMIRHAS_13610	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
THMIRHAS_13620	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
THMIRHAS_13630	COG0287	Prephenate dehydrogenase
THMIRHAS_13640	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
THMIRHAS_13650	COG0077	Prephenate dehydratase
THMIRHAS_13650	COG1605	Chorismate mutase
THMIRHAS_13660	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
THMIRHAS_13680	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
THMIRHAS_13700	COG1028	Short-chain dehydrogenase reductase Sdr
THMIRHAS_13730	COG0601	transmembrane transport
THMIRHAS_13740	COG0747	negative chemotaxis
THMIRHAS_13770	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
THMIRHAS_13780	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
THMIRHAS_13790	COG0740	serine-type endopeptidase activity
THMIRHAS_13800	COG0544	peptidyl-prolyl cis-trans isomerase activity
THMIRHAS_13810	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
THMIRHAS_13900	COG1131	(ABC) transporter
THMIRHAS_13910	COG0842	Transport permease protein
THMIRHAS_13920	COG2850	peptidyl-arginine hydroxylation
THMIRHAS_13930	COG3118	belongs to the thioredoxin family
THMIRHAS_13950	COG1185	polyribonucleotide nucleotidyltransferase activity
THMIRHAS_13960	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
THMIRHAS_13980	COG0500	methyltransferase
THMIRHAS_13990	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
THMIRHAS_14000	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
THMIRHAS_14010	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
THMIRHAS_14020	COG0195	Participates in both transcription termination and antitermination
THMIRHAS_14030	COG0779	Required for maturation of 30S ribosomal subunits
THMIRHAS_14040	COG2176	DNA-directed DNA polymerase activity
THMIRHAS_14060	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
THMIRHAS_14080	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
THMIRHAS_14100	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
THMIRHAS_14140	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
THMIRHAS_14160	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
THMIRHAS_14180	COG0542	response to heat
THMIRHAS_14190	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
THMIRHAS_14210	COG2824	Alkylphosphonate utilization operon protein PhnA
THMIRHAS_14220	COG0217	transcriptional regulatory protein
THMIRHAS_14270	COG0482	sulfurtransferase activity
THMIRHAS_14280	COG2915	High frequency lysogenization protein hflD homolog
THMIRHAS_14300	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
THMIRHAS_14320	COG0745	RESPONSE REGULATOR receiver
THMIRHAS_14350	COG2433	Pfam Transposase IS66
THMIRHAS_14360	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
THMIRHAS_14370	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
THMIRHAS_14380	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
THMIRHAS_14390	COG0330	HflC and HflK could
THMIRHAS_14400	COG0330	HflC and HflK could
THMIRHAS_14410	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
THMIRHAS_14420	COG1923	regulation of RNA biosynthetic process
THMIRHAS_14430	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
THMIRHAS_14450	COG0489	protein tyrosine kinase activity
THMIRHAS_14460	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
THMIRHAS_14460	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
THMIRHAS_14470	COG4657	Part of a membrane complex involved in electron transport
THMIRHAS_14480	COG2878	Part of a membrane complex involved in electron transport
THMIRHAS_14490	COG4656	Part of a membrane complex involved in electron transport
THMIRHAS_14520	COG4660	Part of a membrane complex involved in electron transport
THMIRHAS_14540	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
THMIRHAS_14570	COG1280	lysine exporter protein (LysE YggA)
THMIRHAS_14590	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
THMIRHAS_14610	COG0519	Catalyzes the synthesis of GMP from XMP
THMIRHAS_14610	COG0518	GMP synthase (glutamine-hydrolyzing) activity
THMIRHAS_14620	COG2801	Transposase and inactivated derivatives
THMIRHAS_14640	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
THMIRHAS_14660	COG4206	TonB-dependent receptor
THMIRHAS_14670	COG1492	cobalamin metabolic process
THMIRHAS_14700	COG3002	Belongs to the UPF0753 family
THMIRHAS_14710	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
THMIRHAS_14720	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
THMIRHAS_14720	COG3264	Mechanosensitive ion channel
THMIRHAS_14750	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
THMIRHAS_14760	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
THMIRHAS_14770	COG2814	Major facilitator Superfamily
THMIRHAS_14790	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
THMIRHAS_14800	COG2835	tetraacyldisaccharide 4'-kinase activity
THMIRHAS_14810	COG1663	tetraacyldisaccharide 4'-kinase activity
THMIRHAS_14820	COG2333	competence protein COMEC
THMIRHAS_14820	COG0658	competence protein
THMIRHAS_14840	COG1067	ATP-dependent peptidase activity
THMIRHAS_14850	COG0004	ammonium transporteR
THMIRHAS_14930	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
THMIRHAS_14980	COG0736	holo-[acyl-carrier-protein] synthase activity
THMIRHAS_14990	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
THMIRHAS_15010	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
THMIRHAS_15020	COG0571	ribonuclease III activity
THMIRHAS_15040	COG0481	GTPase activity
THMIRHAS_15050	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
THMIRHAS_15080	COG0835	chemotaxis
THMIRHAS_15130	COG1216	Glycosyl transferase, family 2
THMIRHAS_15130	COG0438	transferase activity, transferring glycosyl groups
THMIRHAS_15170	COG2433	Pfam Transposase IS66
THMIRHAS_15240	COG4372	Transposase
THMIRHAS_15380	COG2433	Pfam Transposase IS66
THMIRHAS_15400	COG2801	Transposase and inactivated derivatives
THMIRHAS_15410	COG2433	Pfam Transposase IS66
THMIRHAS_15420	COG2433	Pfam Transposase IS66
THMIRHAS_15530	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
THMIRHAS_15530	COG2124	cytochrome p450
THMIRHAS_15550	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
THMIRHAS_15580	COG2197	response regulator
THMIRHAS_15600	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
THMIRHAS_15610	COG0300	oxidoreductase activity
THMIRHAS_15620	COG0746	molybdenum cofactor guanylyltransferase activity
THMIRHAS_15630	COG0303	'Molybdopterin
THMIRHAS_15640	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
THMIRHAS_15650	COG1648	precorrin-2 dehydrogenase activity
THMIRHAS_15650	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
THMIRHAS_15660	COG0243	molybdopterin cofactor binding
THMIRHAS_15670	COG2146	nitrite reductase [NAD(P)H] activity
THMIRHAS_15680	COG0515	serine threonine protein kinase
THMIRHAS_15690	COG2223	nitrite transmembrane transporter activity
THMIRHAS_15720	COG1595	DNA-templated transcription, initiation
THMIRHAS_15740	COG1187	pseudouridine synthase activity
THMIRHAS_15760	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
THMIRHAS_15780	COG0442	prolyl-tRNA aminoacylation
THMIRHAS_15800	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
THMIRHAS_15830	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
THMIRHAS_15870	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
THMIRHAS_15900	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
THMIRHAS_15910	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
THMIRHAS_15930	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
THMIRHAS_15940	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
THMIRHAS_15960	COG0717	Belongs to the dCTP deaminase family
THMIRHAS_15970	COG0189	ligase activity
THMIRHAS_15980	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
THMIRHAS_15990	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
THMIRHAS_16000	COG1116	anion transmembrane transporter activity
THMIRHAS_16020	COG1116	anion transmembrane transporter activity
THMIRHAS_16020	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
THMIRHAS_16050	COG1940	carbohydrate kinase activity
THMIRHAS_16060	COG2833	Protein of unknown function (DUF455)
THMIRHAS_16090	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
THMIRHAS_16110	COG0505	Belongs to the CarA family
THMIRHAS_16120	COG0791	NLP P60 protein
THMIRHAS_16130	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
THMIRHAS_16140	COG0484	heat shock protein binding
THMIRHAS_16150	COG0443	Heat shock 70 kDa protein
THMIRHAS_16160	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
THMIRHAS_16170	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
THMIRHAS_16180	COG0497	DNA recombination
THMIRHAS_16190	COG0735	belongs to the Fur family
THMIRHAS_16240	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
THMIRHAS_16250	COG3706	GGDEF domain
THMIRHAS_16260	COG3706	GGDEF domain
THMIRHAS_16300	COG0084	hydrolase, TatD family'
THMIRHAS_16310	COG0470	DNA polymerase III
THMIRHAS_16320	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
THMIRHAS_16330	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
THMIRHAS_16340	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
THMIRHAS_16350	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
THMIRHAS_16360	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
THMIRHAS_16370	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
THMIRHAS_16380	COG1028	Short-chain dehydrogenase reductase Sdr
THMIRHAS_16390	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
THMIRHAS_16400	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
THMIRHAS_16410	COG0416	fatty acid biosynthetic process
THMIRHAS_16420	COG0333	Belongs to the bacterial ribosomal protein bL32 family
THMIRHAS_16440	COG0424	maF-like protein
THMIRHAS_16450	COG0546	phosphoglycolate phosphatase activity
THMIRHAS_16460	COG0564	pseudouridine synthase activity
THMIRHAS_16470	COG1530	ribonuclease E activity
THMIRHAS_16480	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
THMIRHAS_16520	COG0582	viral genome integration into host DNA
THMIRHAS_17060	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
THMIRHAS_17200	COG2894	cell division
THMIRHAS_17240	COG0210	DNA helicase
THMIRHAS_17260	COG1007	ATP synthesis coupled electron transport
THMIRHAS_17290	COG0713	ATP synthesis coupled electron transport
THMIRHAS_17310	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
THMIRHAS_17320	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
THMIRHAS_17330	COG1034	ATP synthesis coupled electron transport
THMIRHAS_17360	COG0649	NAD binding
THMIRHAS_17370	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
THMIRHAS_17380	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
THMIRHAS_17390	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
THMIRHAS_17410	COG0149	triose-phosphate isomerase activity
THMIRHAS_17420	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
THMIRHAS_17430	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
THMIRHAS_17450	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
THMIRHAS_17460	COG1534	Rna-binding protein
THMIRHAS_17500	COG0285	dihydrofolate synthase activity
THMIRHAS_17510	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
THMIRHAS_17520	COG0159	tryptophan synthase activity
THMIRHAS_17540	COG0135	phosphoribosylanthranilate isomerase activity
THMIRHAS_17550	COG0101	tRNA pseudouridine synthase activity
THMIRHAS_17560	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
THMIRHAS_17580	COG0739	heme binding
THMIRHAS_17590	COG0473	3-isopropylmalate dehydrogenase activity
THMIRHAS_17600	COG0066	3-isopropylmalate dehydratase activity
THMIRHAS_17610	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
THMIRHAS_17620	COG0602	queuosine metabolic process
THMIRHAS_17630	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
THMIRHAS_17640	COG0583	DNA-binding transcription factor activity
THMIRHAS_17650	COG0583	DNA-binding transcription factor activity
THMIRHAS_17660	COG0730	response to heat
THMIRHAS_17680	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
THMIRHAS_17700	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
THMIRHAS_17710	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
THMIRHAS_17750	COG0803	Belongs to the bacterial solute-binding protein 9 family
THMIRHAS_17760	COG1121	(ABC) transporter
THMIRHAS_17770	COG1321	iron dependent repressor
THMIRHAS_17770	COG1108	ABC-type Mn2 Zn2 transport systems permease components
THMIRHAS_17780	COG1108	ABC-type Mn2 Zn2 transport systems permease components
THMIRHAS_17810	COG0659	secondary active sulfate transmembrane transporter activity
THMIRHAS_17830	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
THMIRHAS_17840	COG1518	maintenance of DNA repeat elements
THMIRHAS_17860	COG1857	crispr-associated protein
THMIRHAS_17930	COG3123	guanosine phosphorylase activity
THMIRHAS_17960	COG0735	belongs to the Fur family
THMIRHAS_17970	COG2814	Major facilitator Superfamily
THMIRHAS_17980	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
THMIRHAS_18000	COG3338	carbonate dehydratase activity
THMIRHAS_18010	COG2890	protein-(glutamine-N5) methyltransferase activity
THMIRHAS_18020	COG0521	Mo-molybdopterin cofactor biosynthetic process
THMIRHAS_18030	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
THMIRHAS_18060	COG4181	ATPase activity
THMIRHAS_18070	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
THMIRHAS_18130	COG0776	regulation of translation
THMIRHAS_18140	COG0072	phenylalanine-tRNA ligase activity
THMIRHAS_18140	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
THMIRHAS_18150	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
THMIRHAS_18160	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
THMIRHAS_18170	COG0291	Belongs to the bacterial ribosomal protein bL35 family
THMIRHAS_18190	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
THMIRHAS_18210	COG4771	TonB-dependent receptor
THMIRHAS_18250	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
THMIRHAS_18290	COG0446	pyridine nucleotide-disulphide oxidoreductase
THMIRHAS_18300	COG2863	cytochrome
THMIRHAS_18320	COG3608	succinylglutamate desuccinylase aspartoacylase
THMIRHAS_18330	COG0189	ligase activity
THMIRHAS_18350	COG2199	diguanylate cyclase activity
THMIRHAS_18350	COG2200	EAL domain
THMIRHAS_18360	COG0679	Auxin Efflux Carrier
THMIRHAS_18430	COG2433	Pfam Transposase IS66
THMIRHAS_18440	COG2755	lipolytic protein G-D-S-L family
THMIRHAS_18440	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
THMIRHAS_18450	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
THMIRHAS_18470	COG0028	Belongs to the TPP enzyme family
THMIRHAS_18480	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
THMIRHAS_18490	COG0501	Belongs to the peptidase M48B family
THMIRHAS_18500	COG2154	pterin-4-alpha-carbinolamine dehydratase
THMIRHAS_18510	COG1162	GTPase activity
THMIRHAS_18560	COG1160	GTP binding
THMIRHAS_18590	COG0124	histidyl-tRNA synthetase
THMIRHAS_18610	COG0820	rRNA (adenine-C2-)-methyltransferase activity
THMIRHAS_18620	COG0105	UTP biosynthetic process
THMIRHAS_18640	COG1959	2 iron, 2 sulfur cluster binding
THMIRHAS_18680	COG0456	acetyltransferase
THMIRHAS_18700	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
THMIRHAS_18710	COG1183	phosphatidylcholine synthase activity
THMIRHAS_18720	COG2210	Belongs to the sulfur carrier protein TusA family
THMIRHAS_18740	COG4783	chaperone-mediated protein folding
THMIRHAS_18780	COG3258	Cytochrome c
THMIRHAS_18800	COG0129	dihydroxy-acid dehydratase activity
THMIRHAS_18820	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
THMIRHAS_18830	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
THMIRHAS_18840	COG0367	asparagine synthase
THMIRHAS_18860	COG0247	lactate metabolic process
THMIRHAS_18870	COG0277	FAD linked oxidase domain protein
THMIRHAS_18880	COG0277	FAD linked oxidase domain protein
THMIRHAS_18890	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
THMIRHAS_18900	COG4221	oxidoreductase activity
THMIRHAS_18910	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
THMIRHAS_18920	COG0352	thiamine-phosphate diphosphorylase activity
THMIRHAS_18930	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
THMIRHAS_18940	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
THMIRHAS_18950	COG0653	protein targeting
THMIRHAS_18970	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
THMIRHAS_18990	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
THMIRHAS_19000	COG1181	Belongs to the D-alanine--D-alanine ligase family
THMIRHAS_19010	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
THMIRHAS_19030	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
THMIRHAS_19040	COG0719	Fe-S assembly protein
THMIRHAS_19050	COG0396	ATPase activity
THMIRHAS_19060	COG0719	Fe-S assembly protein
THMIRHAS_19080	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
THMIRHAS_19090	COG1121	(ABC) transporter
THMIRHAS_19100	COG1108	ABC-type Mn2 Zn2 transport systems permease components
THMIRHAS_19110	COG0840	transmembrane signaling receptor activity
THMIRHAS_19120	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
THMIRHAS_19140	COG4149	molybdate abc transporter
THMIRHAS_19170	COG3585	molybdate ion transport
THMIRHAS_19190	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
THMIRHAS_19230	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
THMIRHAS_19250	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
THMIRHAS_19260	COG0772	Belongs to the SEDS family
THMIRHAS_19270	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
THMIRHAS_19280	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
THMIRHAS_19290	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
THMIRHAS_19300	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
THMIRHAS_19340	COG0275	rRNA processing
THMIRHAS_19390	COG0742	ribosomal rna small subunit methyltransferase
THMIRHAS_19410	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
THMIRHAS_19420	COG3107	peptidoglycan biosynthetic process
THMIRHAS_19430	COG0792	nuclease activity
THMIRHAS_19440	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
THMIRHAS_19440	COG0574	Belongs to the PEP-utilizing enzyme family
THMIRHAS_19450	COG4106	trans-aconitate 2-methyltransferase activity
THMIRHAS_19460	COG1074	ATP-dependent DNA helicase activity
THMIRHAS_19480	COG2801	Transposase and inactivated derivatives
THMIRHAS_19500	COG1278	Cold shock
THMIRHAS_19510	COG1278	Cold shock
THMIRHAS_19530	COG0564	pseudouridine synthase activity
THMIRHAS_19560	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
THMIRHAS_19570	COG3038	cytochrome b561
THMIRHAS_19590	COG0501	Belongs to the peptidase M48B family
THMIRHAS_19600	COG1704	LemA family
THMIRHAS_19620	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
THMIRHAS_19640	COG1304	FMN binding
THMIRHAS_19650	COG3425	synthase
THMIRHAS_19690	COG2969	positive regulation of protein catabolic process
THMIRHAS_19700	COG0625	glutathione transferase activity
THMIRHAS_19720	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
THMIRHAS_19730	COG1509	lysine 2,3-aminomutase activity
THMIRHAS_19760	COG1322	Protein conserved in bacteria
THMIRHAS_19830	COG1450	Type ii and iii secretion system protein
THMIRHAS_19840	COG3267	Type II secretory pathway component ExeA
THMIRHAS_19840	COG3409	Peptidoglycan-binding domain 1 protein
THMIRHAS_19860	COG1530	ribonuclease E activity
THMIRHAS_19870	COG0424	maF-like protein
THMIRHAS_19900	COG0463	Glycosyl transferase, family 2
THMIRHAS_19960	COG0859	PFAM glycosyl transferase family 9
THMIRHAS_19980	COG1132	(ABC) transporter
THMIRHAS_19990	COG1560	Kdo2-lipid A biosynthetic process
THMIRHAS_20000	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
THMIRHAS_20000	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
THMIRHAS_20010	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
THMIRHAS_20050	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
THMIRHAS_20060	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
THMIRHAS_20080	COG2433	Pfam Transposase IS66
THMIRHAS_20110	COG2801	Transposase and inactivated derivatives
THMIRHAS_20160	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
THMIRHAS_20170	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
THMIRHAS_20180	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
THMIRHAS_20250	COG4964	Belongs to the GSP D family
THMIRHAS_20330	COG2945	thiolester hydrolase activity
THMIRHAS_20340	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
THMIRHAS_20400	COG4232	protein-disulfide reductase activity
THMIRHAS_20410	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
THMIRHAS_20420	COG0511	ligase activity, forming carbon-carbon bonds
THMIRHAS_20430	COG0439	Biotin carboxylase
THMIRHAS_20440	COG2264	protein methyltransferase activity
THMIRHAS_20450	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
THMIRHAS_20460	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
THMIRHAS_20470	COG0138	bifunctional purine biosynthesis protein purh
THMIRHAS_20480	COG0151	Belongs to the GarS family
THMIRHAS_20510	COG4133	protoheme IX ABC transporter activity
THMIRHAS_20530	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
THMIRHAS_20540	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
THMIRHAS_20550	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
THMIRHAS_20560	COG1138	Cytochrome C-type biogenesis protein
THMIRHAS_20570	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
THMIRHAS_20600	COG3005	denitrification pathway
THMIRHAS_20610	COG2863	cytochrome
THMIRHAS_20620	COG0446	pyridine nucleotide-disulphide oxidoreductase
THMIRHAS_20630	COG0446	pyridine nucleotide-disulphide oxidoreductase
THMIRHAS_20660	COG0446	pyridine nucleotide-disulphide oxidoreductase
THMIRHAS_20670	COG0542	response to heat
THMIRHAS_20710	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
THMIRHAS_20710	COG0116	Belongs to the methyltransferase superfamily
THMIRHAS_20720	COG2951	lytic endotransglycosylase activity
THMIRHAS_20750	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
THMIRHAS_20760	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
THMIRHAS_20770	COG0196	riboflavin kinase activity
THMIRHAS_20800	COG0028	Belongs to the TPP enzyme family
THMIRHAS_20810	COG0268	Binds directly to 16S ribosomal RNA
THMIRHAS_20840	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
THMIRHAS_20850	COG0799	negative regulation of ribosome biogenesis
THMIRHAS_20860	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
THMIRHAS_20870	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
THMIRHAS_20900	COG0495	leucyl-tRNA aminoacylation
THMIRHAS_20920	COG0815	Transfers the fatty acyl group on membrane lipoproteins
THMIRHAS_20930	COG4535	Mg2 and Co2 transporter CorC
THMIRHAS_20940	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
THMIRHAS_20950	COG1702	phosphate starvation-inducible protein PhoH
THMIRHAS_20960	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
THMIRHAS_20980	COG3852	Histidine kinase
THMIRHAS_20990	COG0745	RESPONSE REGULATOR receiver
THMIRHAS_21030	COG2165	general secretion pathway protein
THMIRHAS_21060	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
THMIRHAS_21070	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
THMIRHAS_21100	COG1610	YqeY-like protein
THMIRHAS_21110	COG0828	Belongs to the bacterial ribosomal protein bS21 family
THMIRHAS_21120	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
THMIRHAS_21130	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
THMIRHAS_21140	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
THMIRHAS_21180	COG1968	undecaprenyl-diphosphatase activity
THMIRHAS_21200	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
THMIRHAS_21200	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
THMIRHAS_21220	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
THMIRHAS_21240	COG5001	Diguanylate cyclase
THMIRHAS_21240	COG5002	protein histidine kinase activity
THMIRHAS_21250	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
THMIRHAS_21260	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
THMIRHAS_21270	COG1385	rRNA (uridine-N3-)-methyltransferase activity
THMIRHAS_21290	COG0189	ligase activity
THMIRHAS_21310	COG1678	Uncharacterized ACR, COG1678
THMIRHAS_21320	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
THMIRHAS_21330	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
THMIRHAS_21340	COG0540	Belongs to the ATCase OTCase family
THMIRHAS_21350	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
THMIRHAS_21390	COG2326	polyphosphate kinase activity
THMIRHAS_21430	COG0762	integral membrane protein
THMIRHAS_21440	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
THMIRHAS_21470	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
THMIRHAS_21500	COG0748	coenzyme F420 binding
THMIRHAS_21510	COG0400	carboxylic ester hydrolase activity
THMIRHAS_21530	COG0019	diaminopimelate decarboxylase activity
THMIRHAS_21560	COG0509	glycine decarboxylation via glycine cleavage system
THMIRHAS_21580	COG1366	Belongs to the anti-sigma-factor antagonist family
THMIRHAS_21590	COG0789	Transcriptional regulator
THMIRHAS_21600	COG0415	Belongs to the DNA photolyase family
THMIRHAS_21660	COG0300	oxidoreductase activity
THMIRHAS_21690	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
THMIRHAS_21700	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
THMIRHAS_21710	COG3850	Histidine kinase
THMIRHAS_21710	COG2205	protein histidine kinase activity
THMIRHAS_21710	COG4999	Histidine kinase
THMIRHAS_21710	COG3437	response regulator, receiver
THMIRHAS_21720	COG2433	Pfam Transposase IS66
THMIRHAS_21790	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
THMIRHAS_21810	COG0316	Belongs to the HesB IscA family
THMIRHAS_21820	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
THMIRHAS_21830	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
THMIRHAS_21840	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
THMIRHAS_21860	COG0459	protein refolding
THMIRHAS_21870	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
THMIRHAS_21890	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
THMIRHAS_21900	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
THMIRHAS_21910	COG0211	Belongs to the bacterial ribosomal protein bL27 family
THMIRHAS_21920	COG0261	This protein binds to 23S rRNA in the presence of protein L20
THMIRHAS_21930	COG0142	geranyltranstransferase activity
THMIRHAS_21950	COG0629	single-stranded DNA binding
THMIRHAS_21960	COG2814	Major facilitator Superfamily
THMIRHAS_22000	COG0837	glucose binding
THMIRHAS_22010	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
THMIRHAS_22030	COG0203	ribosomal protein L17
THMIRHAS_22040	COG0202	RNA polymerase activity
THMIRHAS_22050	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
THMIRHAS_22060	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
THMIRHAS_22070	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
THMIRHAS_22080	COG0201	protein transport
THMIRHAS_22090	COG0200	Binds to the 23S rRNA
THMIRHAS_22100	COG1841	ribosomal large subunit assembly
THMIRHAS_22110	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
THMIRHAS_22120	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
THMIRHAS_22130	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
THMIRHAS_22140	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
THMIRHAS_22150	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
THMIRHAS_22160	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
THMIRHAS_22170	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
THMIRHAS_22180	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
THMIRHAS_22190	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
THMIRHAS_22200	COG0255	Belongs to the universal ribosomal protein uL29 family
THMIRHAS_22210	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
THMIRHAS_22220	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
THMIRHAS_22230	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
THMIRHAS_22240	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
THMIRHAS_22250	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
THMIRHAS_22260	COG0089	rRNA binding
THMIRHAS_22270	COG0088	Forms part of the polypeptide exit tunnel
THMIRHAS_22280	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
THMIRHAS_22290	COG0051	transcription antitermination factor activity, RNA binding
THMIRHAS_22300	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
THMIRHAS_22310	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
THMIRHAS_22320	COG0049	tRNA binding
THMIRHAS_22330	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
THMIRHAS_22340	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
THMIRHAS_22350	COG0085	RNA polymerase activity
THMIRHAS_22360	COG0222	ribosome binding
THMIRHAS_22370	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
THMIRHAS_22380	COG0081	regulation of translation
THMIRHAS_22390	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
THMIRHAS_22410	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
THMIRHAS_22420	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
THMIRHAS_22440	COG0564	pseudouridine synthase activity
THMIRHAS_22450	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
THMIRHAS_22480	COG2801	Transposase and inactivated derivatives
THMIRHAS_22510	COG1012	belongs to the aldehyde dehydrogenase family
THMIRHAS_22540	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
THMIRHAS_22570	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
THMIRHAS_22600	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
THMIRHAS_22610	COG0588	phosphoglycerate mutase activity
THMIRHAS_22640	COG0668	transmembrane transport
THMIRHAS_22650	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
THMIRHAS_22660	COG1666	GTP binding
THMIRHAS_22670	COG0436	Aminotransferase
THMIRHAS_22720	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
THMIRHAS_22730	COG0355	proton-transporting ATP synthase activity, rotational mechanism
THMIRHAS_22750	COG0356	it plays a direct role in the translocation of protons across the membrane
THMIRHAS_22770	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
THMIRHAS_22770	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
THMIRHAS_22800	COG0756	dUTP diphosphatase activity
THMIRHAS_22820	COG0033	Phosphoglucomutase
THMIRHAS_22850	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
THMIRHAS_22860	COG0590	tRNA wobble adenosine to inosine editing
THMIRHAS_22880	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
THMIRHAS_22910	COG0446	pyridine nucleotide-disulphide oxidoreductase
THMIRHAS_22940	COG2003	Belongs to the UPF0758 family
THMIRHAS_22980	COG0227	Belongs to the bacterial ribosomal protein bL28 family
THMIRHAS_22990	COG0267	Belongs to the bacterial ribosomal protein bL33 family
THMIRHAS_23020	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
THMIRHAS_23040	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
THMIRHAS_23100	COG0450	alkyl hydroperoxide reductase
THMIRHAS_23110	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
THMIRHAS_23120	COG0742	ribosomal rna small subunit methyltransferase
THMIRHAS_23130	COG0583	DNA-binding transcription factor activity
THMIRHAS_23140	COG5002	protein histidine kinase activity
THMIRHAS_23140	COG2205	protein histidine kinase activity
THMIRHAS_23140	COG0784	Response regulator, receiver
THMIRHAS_23160	COG0612	Peptidase, M16
THMIRHAS_23170	COG0612	Peptidase, M16
THMIRHAS_23180	COG0552	protein localization to endoplasmic reticulum
THMIRHAS_23220	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
THMIRHAS_23230	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
THMIRHAS_23250	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
THMIRHAS_23260	COG0167	dihydroorotate dehydrogenase activity
THMIRHAS_23270	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
THMIRHAS_23280	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
THMIRHAS_23290	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
THMIRHAS_23320	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
THMIRHAS_23330	COG0070	glutamate synthase
THMIRHAS_23330	COG0069	glutamate synthase activity
THMIRHAS_23330	COG0067	glutamate synthase
THMIRHAS_23340	COG0493	'glutamate synthase
THMIRHAS_23370	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
THMIRHAS_23390	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
THMIRHAS_23430	COG4771	TonB-dependent receptor
THMIRHAS_23450	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
THMIRHAS_23460	COG0390	transport system, permease component
THMIRHAS_23480	COG4619	ABC transporter
THMIRHAS_23490	COG0210	DNA helicase
THMIRHAS_23520	COG0254	rRNA binding
THMIRHAS_23540	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
THMIRHAS_23560	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
THMIRHAS_23570	COG1194	a g-specific adenine glycosylase
THMIRHAS_23580	COG0220	tRNA (guanine-N7-)-methyltransferase activity
THMIRHAS_23600	COG0635	Involved in the biosynthesis of porphyrin-containing compound
THMIRHAS_23610	COG2814	Major facilitator Superfamily
THMIRHAS_23620	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
THMIRHAS_23630	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
THMIRHAS_23640	COG1561	YicC-like family, N-terminal region
THMIRHAS_23650	COG3550	peptidyl-serine autophosphorylation
THMIRHAS_23660	COG3620	sequence-specific DNA binding
THMIRHAS_23780	COG3001	Fructosamine kinase
THMIRHAS_23790	COG0563	adenylate kinase activity
THMIRHAS_23840	COG2205	protein histidine kinase activity
THMIRHAS_23850	COG0745	RESPONSE REGULATOR receiver
THMIRHAS_23860	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
THMIRHAS_23870	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
THMIRHAS_23880	COG3706	GGDEF domain
THMIRHAS_23930	COG4372	Transposase
THMIRHAS_23960	COG2801	Transposase and inactivated derivatives
THMIRHAS_23980	COG4372	Transposase
THMIRHAS_24010	COG1429	ligase activity, forming nitrogen-metal bonds
THMIRHAS_24020	COG4771	TonB-dependent receptor
THMIRHAS_24030	COG1429	ligase activity, forming nitrogen-metal bonds
THMIRHAS_24060	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
THMIRHAS_24070	COG1854	S-ribosylhomocysteine lyase activity
THMIRHAS_24090	COG3046	protein related to deoxyribodipyrimidine photolyase
THMIRHAS_24100	COG2176	DNA-directed DNA polymerase activity
THMIRHAS_24110	COG0415	Belongs to the DNA photolyase family
THMIRHAS_24140	COG0259	pyridoxamine-phosphate oxidase activity
THMIRHAS_24150	COG0745	RESPONSE REGULATOR receiver
THMIRHAS_24160	COG2205	protein histidine kinase activity
THMIRHAS_24160	COG3437	response regulator, receiver
THMIRHAS_24160	COG4999	Histidine kinase
THMIRHAS_24160	COG3850	Histidine kinase
THMIRHAS_24180	COG1741	Belongs to the pirin family
THMIRHAS_24190	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
THMIRHAS_24210	COG0840	transmembrane signaling receptor activity
THMIRHAS_24210	COG0840	transmembrane signaling receptor activity
THMIRHAS_24220	COG0330	HflC and HflK could
THMIRHAS_24270	COG0840	transmembrane signaling receptor activity
THMIRHAS_24290	COG0583	DNA-binding transcription factor activity
THMIRHAS_24310	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
THMIRHAS_24440	COG1850	ribulose-bisphosphate carboxylase activity
THMIRHAS_24480	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
THMIRHAS_24510	COG1262	PFAM Formylglycine-generating sulfatase enzyme
THMIRHAS_24520	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
THMIRHAS_24550	COG0676	glucose-6-phosphate 1-epimerase activity
THMIRHAS_24560	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
THMIRHAS_24570	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
THMIRHAS_24580	COG0194	GDP metabolic process
THMIRHAS_24590	COG1758	RNA polymerase activity
THMIRHAS_24600	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
THMIRHAS_24620	COG0561	phosphatase activity
THMIRHAS_24630	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
THMIRHAS_24640	COG3161	chorismate lyase activity
THMIRHAS_24670	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
THMIRHAS_24690	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
THMIRHAS_24700	COG0355	proton-transporting ATP synthase activity, rotational mechanism
THMIRHAS_24710	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
THMIRHAS_24730	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
THMIRHAS_24740	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
THMIRHAS_24750	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
THMIRHAS_24760	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
THMIRHAS_24770	COG0356	it plays a direct role in the translocation of protons across the membrane
THMIRHAS_24810	COG1192	Involved in chromosome partitioning
THMIRHAS_24820	COG0357	Ribosomal RNA small subunit methyltransferase G
THMIRHAS_24830	COG0445	tRNA wobble uridine modification
THMIRHAS_24860	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
THMIRHAS_24860	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
THMIRHAS_24890	COG1739	Uncharacterized protein family UPF0029
THMIRHAS_24900	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
THMIRHAS_24930	COG0840	transmembrane signaling receptor activity
THMIRHAS_24950	COG2095	MarC family integral membrane protein
THMIRHAS_24960	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
THMIRHAS_24980	COG0706	membrane insertase activity
THMIRHAS_24990	COG0594	ribonuclease P activity
THMIRHAS_25000	COG0230	Belongs to the bacterial ribosomal protein bL34 family
THMIRHAS_25010	COG0730	response to heat