locus-tag	class	description
THIAE_00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
THIAE_00020	COG0446	pyridine nucleotide-disulphide oxidoreductase
THIAE_00025	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
THIAE_00030	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
THIAE_00035	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
THIAE_00040	COG0314	molybdopterin synthase activity
THIAE_00045	COG0303	'Molybdopterin
THIAE_00050	COG0315	cyclic pyranopterin monophosphate synthase activity
THIAE_00060	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
THIAE_00065	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
THIAE_00070	COG1854	S-ribosylhomocysteine lyase activity
THIAE_00090	COG3437	response regulator, receiver
THIAE_00090	COG0784	Response regulator, receiver
THIAE_00105	COG5001	Diguanylate cyclase
THIAE_00105	COG4251	negative regulation of phosphorylation
THIAE_00105	COG3706	GGDEF domain
THIAE_00105	COG2203	Gaf domain
THIAE_00115	COG0784	Response regulator, receiver
THIAE_00115	COG3437	response regulator, receiver
THIAE_00145	COG2197	response regulator
THIAE_00175	COG1262	PFAM Formylglycine-generating sulfatase enzyme
THIAE_00180	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
THIAE_00185	COG1028	Short-chain dehydrogenase reductase Sdr
THIAE_00190	COG0840	transmembrane signaling receptor activity
THIAE_00195	COG0563	adenylate kinase activity
THIAE_00210	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
THIAE_00215	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
THIAE_00220	COG0635	Involved in the biosynthesis of porphyrin-containing compound
THIAE_00230	COG0513	Belongs to the DEAD box helicase family
THIAE_00270	COG2391	methyltransferase activity
THIAE_00275	COG0659	secondary active sulfate transmembrane transporter activity
THIAE_00295	COG0646	methionine synthase
THIAE_00295	COG1410	methionine synthase
THIAE_00310	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
THIAE_00320	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
THIAE_00325	COG1758	RNA polymerase activity
THIAE_00330	COG0668	transmembrane transport
THIAE_00335	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
THIAE_00340	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
THIAE_00350	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
THIAE_00360	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
THIAE_00365	COG2203	Gaf domain
THIAE_00365	COG4251	negative regulation of phosphorylation
THIAE_00365	COG5001	Diguanylate cyclase
THIAE_00365	COG3706	GGDEF domain
THIAE_00380	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
THIAE_00380	COG0543	2 iron, 2 sulfur cluster binding
THIAE_00385	COG0708	Exodeoxyribonuclease III
THIAE_00390	COG0788	formyltetrahydrofolate deformylase activity
THIAE_00395	COG1444	tRNA N-acetyltransferase activity
THIAE_00400	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
THIAE_00400	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
THIAE_00425	COG0446	pyridine nucleotide-disulphide oxidoreductase
THIAE_00440	COG2081	HI0933 family
THIAE_00455	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
THIAE_00455	COG0678	peroxiredoxin activity
THIAE_00465	COG1519	Transferase
THIAE_00470	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
THIAE_00475	COG1454	alcohol dehydrogenase
THIAE_00480	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
THIAE_00485	COG0194	GDP metabolic process
THIAE_00490	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
THIAE_00495	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
THIAE_00500	COG0676	glucose-6-phosphate 1-epimerase activity
THIAE_00515	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
THIAE_00520	COG3100	YcgL domain-containing protein
THIAE_00525	COG0702	epimerase
THIAE_00530	COG0617	tRNA 3'-terminal CCA addition
THIAE_00550	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
THIAE_00555	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
THIAE_00560	COG0126	phosphoglycerate kinase activity
THIAE_00575	COG1401	restriction endodeoxyribonuclease activity
THIAE_00595	COG2873	o-acetylhomoserine
THIAE_00600	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
THIAE_00605	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
THIAE_00615	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
THIAE_00620	COG0546	phosphoglycolate phosphatase activity
THIAE_00625	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
THIAE_00635	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
THIAE_00640	COG0134	indole-3-glycerol-phosphate synthase activity
THIAE_00645	COG1765	OsmC-like protein
THIAE_00650	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
THIAE_00655	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
THIAE_00660	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
THIAE_00680	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
THIAE_00690	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
THIAE_00700	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
THIAE_00705	COG0081	regulation of translation
THIAE_00710	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
THIAE_00720	COG0085	RNA polymerase activity
THIAE_00725	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
THIAE_00730	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
THIAE_00735	COG0049	tRNA binding
THIAE_00740	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
THIAE_00745	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
THIAE_00750	COG0051	transcription antitermination factor activity, RNA binding
THIAE_00755	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
THIAE_00760	COG0088	Forms part of the polypeptide exit tunnel
THIAE_00765	COG0089	rRNA binding
THIAE_00770	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
THIAE_00775	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
THIAE_00780	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
THIAE_00785	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
THIAE_00790	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
THIAE_00795	COG0255	Belongs to the universal ribosomal protein uL29 family
THIAE_00800	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
THIAE_00805	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
THIAE_00810	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
THIAE_00815	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
THIAE_00820	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
THIAE_00825	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
THIAE_00830	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
THIAE_00835	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
THIAE_00840	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
THIAE_00845	COG1841	ribosomal large subunit assembly
THIAE_00850	COG0200	Binds to the 23S rRNA
THIAE_00855	COG0201	protein transport
THIAE_00860	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
THIAE_00865	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
THIAE_00870	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
THIAE_00875	COG0202	RNA polymerase activity
THIAE_00880	COG0203	ribosomal protein L17
THIAE_00885	COG0084	hydrolase, TatD family'
THIAE_00890	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
THIAE_00900	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
THIAE_00905	COG1116	anion transmembrane transporter activity
THIAE_00910	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
THIAE_00915	COG1116	anion transmembrane transporter activity
THIAE_00915	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
THIAE_00920	COG3604	Transcriptional regulator
THIAE_00925	COG0019	diaminopimelate decarboxylase activity
THIAE_00940	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
THIAE_00970	COG0415	Belongs to the DNA photolyase family
THIAE_00980	COG3046	protein related to deoxyribodipyrimidine photolyase
THIAE_00990	COG2814	Major facilitator Superfamily
THIAE_00995	COG0629	single-stranded DNA binding
THIAE_01005	COG0142	geranyltranstransferase activity
THIAE_01010	COG0261	This protein binds to 23S rRNA in the presence of protein L20
THIAE_01015	COG0211	Belongs to the bacterial ribosomal protein bL27 family
THIAE_01020	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
THIAE_01025	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
THIAE_01030	COG0477	Major facilitator Superfamily
THIAE_01040	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
THIAE_01045	COG4943	cyclic-guanylate-specific phosphodiesterase activity
THIAE_01050	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
THIAE_01055	COG0459	protein refolding
THIAE_01060	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
THIAE_01065	COG0316	Belongs to the HesB IscA family
THIAE_01075	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
THIAE_01080	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
THIAE_01085	COG1366	Belongs to the anti-sigma-factor antagonist family
THIAE_01090	COG0789	Transcriptional regulator
THIAE_01095	COG0415	Belongs to the DNA photolyase family
THIAE_01110	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
THIAE_01125	COG0300	oxidoreductase activity
THIAE_01140	COG1108	ABC-type Mn2 Zn2 transport systems permease components
THIAE_01145	COG1121	(ABC) transporter
THIAE_01160	COG0719	Fe-S assembly protein
THIAE_01165	COG0396	ATPase activity
THIAE_01170	COG0719	Fe-S assembly protein
THIAE_01180	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
THIAE_01185	COG1181	Belongs to the D-alanine--D-alanine ligase family
THIAE_01200	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
THIAE_01210	COG0653	protein targeting
THIAE_01215	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
THIAE_01220	COG0352	thiamine-phosphate diphosphorylase activity
THIAE_01225	COG0237	dephospho-CoA kinase activity
THIAE_01235	COG0367	asparagine synthase
THIAE_01240	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
THIAE_01255	COG0129	dihydroxy-acid dehydratase activity
THIAE_01265	COG3258	Cytochrome c
THIAE_01285	COG4783	chaperone-mediated protein folding
THIAE_01295	COG1210	Utp--glucose-1-phosphate uridylyltransferase
THIAE_01300	COG0166	Belongs to the GPI family
THIAE_01310	COG1183	phosphatidylcholine synthase activity
THIAE_01315	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
THIAE_01325	COG0456	acetyltransferase
THIAE_01345	COG1959	2 iron, 2 sulfur cluster binding
THIAE_01350	COG0316	Belongs to the HesB IscA family
THIAE_01355	COG0105	UTP biosynthetic process
THIAE_01360	COG0820	rRNA (adenine-C2-)-methyltransferase activity
THIAE_01370	COG0124	histidyl-tRNA synthetase
THIAE_01380	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
THIAE_01385	COG1160	GTP binding
THIAE_01390	COG0277	FAD linked oxidase domain protein
THIAE_01410	COG1162	GTPase activity
THIAE_01415	COG2154	pterin-4-alpha-carbinolamine dehydratase
THIAE_01420	COG0501	Belongs to the peptidase M48B family
THIAE_01425	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
THIAE_01430	COG0028	Belongs to the TPP enzyme family
THIAE_01440	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
THIAE_01445	COG0493	'glutamate synthase
THIAE_01450	COG0070	glutamate synthase
THIAE_01450	COG0069	glutamate synthase activity
THIAE_01450	COG0067	glutamate synthase
THIAE_01455	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
THIAE_01460	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
THIAE_01465	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
THIAE_01475	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
THIAE_01480	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
THIAE_01485	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
THIAE_01490	COG0167	dihydroorotate dehydrogenase activity
THIAE_01495	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
THIAE_01525	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
THIAE_01525	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
THIAE_01530	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
THIAE_01540	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
THIAE_01560	COG0552	protein localization to endoplasmic reticulum
THIAE_01565	COG0612	Peptidase, M16
THIAE_01570	COG0612	Peptidase, M16
THIAE_01575	COG0742	ribosomal rna small subunit methyltransferase
THIAE_01580	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
THIAE_01595	COG1666	GTP binding
THIAE_01600	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
THIAE_01625	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
THIAE_01630	COG0248	Ppx GppA phosphatase
THIAE_01640	COG0628	permease
THIAE_01645	COG0756	dUTP diphosphatase activity
THIAE_01650	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
THIAE_01665	COG1090	epimerase
THIAE_01680	COG0509	glycine decarboxylation via glycine cleavage system
THIAE_01690	COG1012	belongs to the aldehyde dehydrogenase family
THIAE_01695	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
THIAE_01700	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
THIAE_01705	COG2026	Addiction module toxin, RelE StbE family
THIAE_01710	COG3077	Addiction module antitoxin, RelB DinJ family
THIAE_01720	COG0732	type I restriction modification DNA specificity domain
THIAE_01735	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
THIAE_01740	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
THIAE_01755	COG0840	transmembrane signaling receptor activity
THIAE_01765	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
THIAE_01770	COG0540	Belongs to the ATCase OTCase family
THIAE_01775	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
THIAE_01780	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
THIAE_01785	COG1678	Uncharacterized ACR, COG1678
THIAE_01790	COG1477	protein flavinylation
THIAE_01800	COG2308	Evidence 4 Homologs of previously reported genes of
THIAE_01815	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
THIAE_01815	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
THIAE_01825	COG0227	Belongs to the bacterial ribosomal protein bL28 family
THIAE_01830	COG2003	Belongs to the UPF0758 family
THIAE_01845	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
THIAE_01845	COG2813	Specifically methylates the guanine in position
THIAE_01850	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
THIAE_01855	COG0762	integral membrane protein
THIAE_01865	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
THIAE_01870	COG1999	signal sequence binding
THIAE_01875	COG0840	transmembrane signaling receptor activity
THIAE_01880	COG1469	GTP cyclohydrolase I activity
THIAE_01885	COG0523	cobalamin synthesis protein
THIAE_01890	COG0579	oxidoreductase
THIAE_01900	COG0667	Aldo Keto reductase
THIAE_01910	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
THIAE_01930	COG0308	aminopeptidase N
THIAE_01965	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
THIAE_01975	COG4771	TonB-dependent receptor
THIAE_01980	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
THIAE_01990	COG2226	methyltransferase
THIAE_02010	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
THIAE_02015	COG0709	Synthesizes selenophosphate from selenide and ATP
THIAE_02020	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
THIAE_02035	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
THIAE_02040	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
THIAE_02045	COG0500	methyltransferase
THIAE_02055	COG0542	response to heat
THIAE_02060	COG3706	GGDEF domain
THIAE_02070	COG2982	Protein involved in outer membrane biogenesis
THIAE_02075	COG2267	carboxylic ester hydrolase activity
THIAE_02100	COG0277	FAD linked oxidase domain protein
THIAE_02105	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
THIAE_02110	COG0351	phosphomethylpyrimidine kinase
THIAE_02115	COG0352	thiamine-phosphate diphosphorylase activity
THIAE_02125	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
THIAE_02160	COG0840	transmembrane signaling receptor activity
THIAE_02160	COG0840	transmembrane signaling receptor activity
THIAE_02175	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
THIAE_02185	COG0668	transmembrane transport
THIAE_02195	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
THIAE_02200	COG1702	phosphate starvation-inducible protein PhoH
THIAE_02205	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
THIAE_02210	COG4535	Mg2 and Co2 transporter CorC
THIAE_02215	COG0815	Transfers the fatty acyl group on membrane lipoproteins
THIAE_02220	COG0174	glutamine synthetase
THIAE_02225	COG0573	inorganic phosphate transmembrane transporter activity
THIAE_02230	COG0581	inorganic phosphate transmembrane transporter activity
THIAE_02235	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
THIAE_02245	COG0745	RESPONSE REGULATOR receiver
THIAE_02270	COG0840	transmembrane signaling receptor activity
THIAE_02305	COG0271	Belongs to the BolA IbaG family
THIAE_02320	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
THIAE_02325	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
THIAE_02335	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
THIAE_02335	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
THIAE_02340	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
THIAE_02345	COG3178	'Phosphotransferase
THIAE_02360	COG3022	response to hydroperoxide
THIAE_02390	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
THIAE_02395	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
THIAE_02400	COG0321	lipoyl(octanoyl) transferase activity
THIAE_02405	COG2921	Belongs to the UPF0250 family
THIAE_02415	COG1686	Belongs to the peptidase S11 family
THIAE_02420	COG0772	Belongs to the SEDS family
THIAE_02425	COG0768	penicillin binding
THIAE_02430	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
THIAE_02435	COG1792	Involved in formation and maintenance of cell shape
THIAE_02440	COG1077	Cell shape determining protein MreB Mrl
THIAE_02445	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
THIAE_02450	COG0154	amidase activity
THIAE_02455	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
THIAE_02460	COG0501	Belongs to the peptidase M48B family
THIAE_02465	COG2166	iron-sulfur cluster assembly
THIAE_02470	COG0617	tRNA 3'-terminal CCA addition
THIAE_02475	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
THIAE_02480	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
THIAE_02485	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
THIAE_02490	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
THIAE_02495	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
THIAE_02500	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
THIAE_02505	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
THIAE_02510	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
THIAE_02515	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
THIAE_02520	COG0557	exoribonuclease II activity
THIAE_02525	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
THIAE_02530	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
THIAE_02535	COG0306	phosphate transporter
THIAE_02540	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
THIAE_02565	COG0713	ATP synthesis coupled electron transport
THIAE_02570	COG0651	ATP synthesis coupled electron transport
THIAE_02575	COG0651	ATP synthesis coupled electron transport
THIAE_02585	COG4804	nuclease activity
THIAE_02595	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
THIAE_02635	COG2133	pyrroloquinoline quinone binding
THIAE_02650	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
THIAE_02650	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
THIAE_02665	COG0714	Associated with various cellular activities
THIAE_02695	COG1007	ATP synthesis coupled electron transport
THIAE_02715	COG0330	HflC and HflK could
THIAE_02740	COG0840	transmembrane signaling receptor activity
THIAE_02740	COG0840	transmembrane signaling receptor activity
THIAE_02745	COG2205	protein histidine kinase activity
THIAE_02745	COG2198	Histidine kinase
THIAE_02745	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
THIAE_02745	COG0784	Response regulator, receiver
THIAE_02750	COG0840	transmembrane signaling receptor activity
THIAE_02815	COG0446	pyridine nucleotide-disulphide oxidoreductase
THIAE_02840	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
THIAE_02845	COG0583	DNA-binding transcription factor activity
THIAE_02860	COG3328	transposase activity
THIAE_02875	COG1595	DNA-templated transcription, initiation
THIAE_02880	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
THIAE_02885	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
THIAE_02895	COG3706	GGDEF domain
THIAE_02910	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
THIAE_02915	COG0739	heme binding
THIAE_02925	COG0752	glycyl-tRNA synthetase alpha subunit
THIAE_02930	COG0751	glycine-tRNA ligase activity
THIAE_02960	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
THIAE_02970	COG0187	DNA topoisomerase II activity
THIAE_02980	COG0028	Belongs to the TPP enzyme family
THIAE_02990	COG0196	riboflavin kinase activity
THIAE_02995	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
THIAE_03000	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
THIAE_03005	COG2199	diguanylate cyclase activity
THIAE_03005	COG2203	Gaf domain
THIAE_03020	COG2951	lytic endotransglycosylase activity
THIAE_03025	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
THIAE_03025	COG0116	Belongs to the methyltransferase superfamily
THIAE_03045	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
THIAE_03070	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
THIAE_03095	COG0006	proline dipeptidase activity
THIAE_03100	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
THIAE_03105	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
THIAE_03110	COG0583	DNA-binding transcription factor activity
THIAE_03125	COG1530	ribonuclease E activity
THIAE_03140	COG0424	maF-like protein
THIAE_03145	COG1399	metal-binding, possibly nucleic acid-binding protein
THIAE_03150	COG0333	Belongs to the bacterial ribosomal protein bL32 family
THIAE_03155	COG0416	fatty acid biosynthetic process
THIAE_03160	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
THIAE_03165	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
THIAE_03175	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
THIAE_03180	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
THIAE_03185	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
THIAE_03195	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
THIAE_03200	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
THIAE_03210	COG0084	hydrolase, TatD family'
THIAE_03215	COG1132	(ABC) transporter
THIAE_03240	COG1047	Peptidyl-prolyl cis-trans
THIAE_03250	COG0045	succinate-CoA ligase (ADP-forming) activity
THIAE_03255	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
THIAE_03260	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
THIAE_03260	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
THIAE_03275	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
THIAE_03280	COG1472	Belongs to the glycosyl hydrolase 3 family
THIAE_03290	COG0733	neurotransmitter:sodium symporter activity
THIAE_03305	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
THIAE_03310	COG1393	Belongs to the ArsC family
THIAE_03330	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
THIAE_03350	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
THIAE_03360	COG2915	High frequency lysogenization protein hflD homolog
THIAE_03365	COG0482	sulfurtransferase activity
THIAE_03380	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
THIAE_03385	COG0542	response to heat
THIAE_03395	COG2515	1-aminocyclopropane-1-carboxylate deaminase
THIAE_03400	COG1067	ATP-dependent peptidase activity
THIAE_03410	COG2333	competence protein COMEC
THIAE_03410	COG0658	competence protein
THIAE_03430	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
THIAE_03440	COG1663	tetraacyldisaccharide 4'-kinase activity
THIAE_03445	COG2835	tetraacyldisaccharide 4'-kinase activity
THIAE_03450	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
THIAE_03460	COG3150	esterase
THIAE_03465	COG0850	regulation of cytokinetic process
THIAE_03470	COG2894	cell division
THIAE_03475	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
THIAE_03485	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
THIAE_03500	COG1136	(ABC) transporter
THIAE_03505	COG0488	(ABC) transporter
THIAE_03525	COG2201	protein-glutamate methylesterase activity
THIAE_03535	COG0513	Belongs to the DEAD box helicase family
THIAE_03555	COG1999	signal sequence binding
THIAE_03565	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
THIAE_03570	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
THIAE_03575	COG4181	ATPase activity
THIAE_03585	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
THIAE_03595	COG2914	Belongs to the UPF0125 (RnfH) family
THIAE_03600	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
THIAE_03605	COG0735	belongs to the Fur family
THIAE_03610	COG0497	DNA recombination
THIAE_03615	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
THIAE_03620	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
THIAE_03625	COG0443	Heat shock 70 kDa protein
THIAE_03630	COG0484	heat shock protein binding
THIAE_03635	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
THIAE_03640	COG0505	Belongs to the CarA family
THIAE_03650	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
THIAE_03660	COG2833	Protein of unknown function (DUF455)
THIAE_03665	COG1940	carbohydrate kinase activity
THIAE_03675	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
THIAE_03685	COG2197	response regulator
THIAE_03695	COG2203	Gaf domain
THIAE_03695	COG2199	diguanylate cyclase activity
THIAE_03700	COG0488	(ABC) transporter
THIAE_03705	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
THIAE_03710	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
THIAE_03715	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
THIAE_03715	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
THIAE_03730	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
THIAE_03735	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
THIAE_03740	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
THIAE_03745	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
THIAE_03760	COG0720	synthase
THIAE_03765	COG0142	geranyltranstransferase activity
THIAE_03770	COG0300	oxidoreductase activity
THIAE_03780	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
THIAE_03785	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
THIAE_03795	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
THIAE_03800	COG0632	four-way junction helicase activity
THIAE_03805	COG2255	four-way junction helicase activity
THIAE_03815	COG0848	biopolymer transport protein
THIAE_03825	COG0823	Involved in the tonB-independent uptake of proteins
THIAE_03840	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
THIAE_03860	COG0354	folic acid binding
THIAE_03865	COG0835	chemotaxis
THIAE_03870	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
THIAE_03880	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
THIAE_03885	COG1815	bacterial-type flagellum-dependent cell motility
THIAE_03890	COG1558	bacterial-type flagellum-dependent cell motility
THIAE_03900	COG1749	Flagellar hook protein flgE
THIAE_03910	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
THIAE_03915	COG0343	queuine tRNA-ribosyltransferase activity
THIAE_03920	COG1862	Preprotein translocase
THIAE_03925	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
THIAE_03930	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
THIAE_03935	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
THIAE_03945	COG0492	ferredoxin-NADP+ reductase activity
THIAE_03955	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
THIAE_03960	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
THIAE_03965	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
THIAE_03970	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
THIAE_03980	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
THIAE_04005	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
THIAE_04010	COG0024	Methionine aminopeptidase
THIAE_04015	COG0052	Belongs to the universal ribosomal protein uS2 family
THIAE_04020	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
THIAE_04025	COG0528	UMP kinase activity
THIAE_04030	COG0233	cytoplasmic translational termination
THIAE_04035	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
THIAE_04040	COG0575	Belongs to the CDS family
THIAE_04050	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
THIAE_04060	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
THIAE_04065	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
THIAE_04070	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
THIAE_04075	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
THIAE_04080	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
THIAE_04085	COG0835	chemotaxis
THIAE_04085	COG0784	Response regulator, receiver
THIAE_04090	COG0257	Belongs to the bacterial ribosomal protein bL36 family
THIAE_04095	COG1199	ATP-dependent helicase activity
THIAE_04100	COG1214	PFAM Peptidase M22, glycoprotease
THIAE_04105	COG0589	response to stress
THIAE_04120	COG1555	photosystem II stabilization
THIAE_04130	COG1132	(ABC) transporter
THIAE_04145	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
THIAE_04175	COG0859	PFAM glycosyl transferase family 9
THIAE_04255	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
THIAE_04385	COG1215	transferase activity, transferring glycosyl groups
THIAE_04390	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
THIAE_04440	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
THIAE_04470	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
THIAE_04475	COG0481	GTPase activity
THIAE_04480	COG0681	Belongs to the peptidase S26 family
THIAE_04485	COG0571	ribonuclease III activity
THIAE_04500	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
THIAE_04505	COG0736	holo-[acyl-carrier-protein] synthase activity
THIAE_04510	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
THIAE_04540	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
THIAE_04545	COG0587	DNA-directed DNA polymerase activity
THIAE_04550	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
THIAE_04565	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
THIAE_04580	COG0779	Required for maturation of 30S ribosomal subunits
THIAE_04585	COG0195	Participates in both transcription termination and antitermination
THIAE_04585	COG2251	uridine kinase activity
THIAE_04590	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
THIAE_04595	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
THIAE_04600	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
THIAE_04605	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
THIAE_04615	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
THIAE_04620	COG1185	polyribonucleotide nucleotidyltransferase activity
THIAE_04640	COG0601	transmembrane transport
THIAE_04645	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
THIAE_04690	COG3530	Putative quorum-sensing-regulated virulence factor
THIAE_04730	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
THIAE_04740	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
THIAE_04760	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
THIAE_04765	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
THIAE_04770	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
THIAE_04790	COG0659	secondary active sulfate transmembrane transporter activity
THIAE_04805	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
THIAE_04810	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
THIAE_04815	COG2183	response to ionizing radiation
THIAE_04835	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
THIAE_04850	COG1028	Short-chain dehydrogenase reductase Sdr
THIAE_04860	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
THIAE_04870	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
THIAE_04880	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
THIAE_04885	COG0287	Prephenate dehydrogenase
THIAE_04890	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
THIAE_04895	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
THIAE_04905	COG0776	regulation of translation
THIAE_04915	COG0284	orotidine-5'-phosphate decarboxylase activity
THIAE_04920	COG0360	Binds together with S18 to 16S ribosomal RNA
THIAE_04925	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
THIAE_04935	COG0359	binds to the 23S rRNA
THIAE_04940	COG0305	Participates in initiation and elongation during chromosome replication
THIAE_04945	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
THIAE_04980	COG3437	response regulator, receiver
THIAE_05005	COG1570	exodeoxyribonuclease VII activity
THIAE_05005	COG1570	exodeoxyribonuclease VII activity
THIAE_05010	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
THIAE_05025	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
THIAE_05030	COG2200	EAL domain
THIAE_05030	COG2199	diguanylate cyclase activity
THIAE_05035	COG0746	molybdenum cofactor guanylyltransferase activity
THIAE_05040	COG0303	'Molybdopterin
THIAE_05050	COG1648	precorrin-2 dehydrogenase activity
THIAE_05050	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
THIAE_05055	COG0243	molybdopterin cofactor binding
THIAE_05065	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
THIAE_05070	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
THIAE_05075	COG1116	anion transmembrane transporter activity
THIAE_05080	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
THIAE_05085	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
THIAE_05090	COG3707	response regulator
THIAE_05095	COG0419	ATPase involved in DNA repair
THIAE_05100	COG0420	3'-5' exonuclease activity
THIAE_05120	COG3012	SEC-C Motif Domain Protein
THIAE_05125	COG2337	Toxic component of a toxin-antitoxin (TA) module
THIAE_05165	COG0322	excinuclease ABC activity
THIAE_05170	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
THIAE_05170	COG0616	signal peptide processing
THIAE_05175	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
THIAE_05180	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
THIAE_05190	COG0363	glucosamine-6-phosphate deaminase activity
THIAE_05195	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
THIAE_05200	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
THIAE_05260	COG1187	pseudouridine synthase activity
THIAE_05265	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
THIAE_05270	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
THIAE_05275	COG1994	Peptidase M50
THIAE_05280	COG0009	L-threonylcarbamoyladenylate synthase
THIAE_05285	COG0613	PHP domain protein
THIAE_05290	COG2917	probably involved in intracellular septation
THIAE_05295	COG2350	Protein conserved in bacteria
THIAE_05300	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
THIAE_05320	COG3028	Belongs to the UPF0307 family
THIAE_05325	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
THIAE_05335	COG1196	nuclear chromosome segregation
THIAE_05340	COG1070	Carbohydrate kinase
THIAE_05350	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
THIAE_05360	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
THIAE_05365	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
THIAE_05375	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
THIAE_05375	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
THIAE_05380	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
THIAE_05395	COG0436	Aminotransferase
THIAE_05405	COG4942	peptidase
THIAE_05410	COG1238	metal cluster binding
THIAE_05415	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
THIAE_05425	COG2840	Smr protein MutS2
THIAE_05430	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
THIAE_05435	COG0148	phosphopyruvate hydratase activity
THIAE_05440	COG2877	3-deoxy-8-phosphooctulonate synthase activity
THIAE_05445	COG0504	CTP synthase activity
THIAE_05455	COG0825	malonyl-CoA metabolic process
THIAE_05465	COG1944	ATP diphosphatase activity
THIAE_05480	COG0564	pseudouridine synthase activity
THIAE_05490	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
THIAE_05495	COG0508	dehydrogenase complex catalyzes the overall conversion of
THIAE_05500	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
THIAE_05505	COG1051	belongs to the nudix hydrolase family
THIAE_05515	COG0716	FMN binding
THIAE_05525	COG3023	N-Acetylmuramoyl-L-alanine amidase
THIAE_05540	COG0564	pseudouridine synthase activity
THIAE_05555	COG0328	RNA-DNA hybrid ribonuclease activity
THIAE_05565	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
THIAE_05570	COG0741	lytic transglycosylase activity
THIAE_05570	COG1388	LysM domain
THIAE_05575	COG0741	lytic transglycosylase activity
THIAE_05580	COG0215	cysteine-tRNA ligase activity
THIAE_05595	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
THIAE_05600	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
THIAE_05605	COG1301	dicarboxylic acid transport
THIAE_05615	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
THIAE_05620	COG0137	argininosuccinate synthase activity
THIAE_05625	COG0688	phosphatidylethanolamine metabolic process
THIAE_05635	COG2204	response regulator
THIAE_05640	COG3852	Histidine kinase
THIAE_05650	COG0803	Belongs to the bacterial solute-binding protein 9 family
THIAE_05655	COG1121	(ABC) transporter
THIAE_05660	COG1321	iron dependent repressor
THIAE_05660	COG1108	ABC-type Mn2 Zn2 transport systems permease components
THIAE_05675	COG1049	propionate catabolic process, 2-methylcitrate cycle
THIAE_05685	COG2850	peptidyl-arginine hydroxylation
THIAE_05725	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
THIAE_05730	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
THIAE_05735	COG0740	serine-type endopeptidase activity
THIAE_05740	COG0544	peptidyl-prolyl cis-trans isomerase activity
THIAE_05745	COG2363	Small membrane protein
THIAE_05840	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
THIAE_05855	COG2963	transposase activity
THIAE_05865	COG1061	Type III restriction enzyme res subunit
THIAE_05925	COG0488	(ABC) transporter
THIAE_05935	COG1047	Peptidyl-prolyl cis-trans
THIAE_05945	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
THIAE_05950	COG2894	cell division
THIAE_05985	COG3328	transposase activity
THIAE_06005	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
THIAE_06055	COG2003	Belongs to the UPF0758 family
THIAE_06180	COG3328	transposase activity
THIAE_06200	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
THIAE_06285	COG0582	viral genome integration into host DNA
THIAE_06300	COG1007	ATP synthesis coupled electron transport
THIAE_06315	COG0713	ATP synthesis coupled electron transport
THIAE_06325	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
THIAE_06330	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
THIAE_06335	COG1034	ATP synthesis coupled electron transport
THIAE_06345	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
THIAE_06350	COG0649	NAD binding
THIAE_06355	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
THIAE_06360	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
THIAE_06365	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
THIAE_06380	COG0149	triose-phosphate isomerase activity
THIAE_06385	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
THIAE_06390	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
THIAE_06395	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
THIAE_06400	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
THIAE_06405	COG1534	Rna-binding protein
THIAE_06425	COG0285	dihydrofolate synthase activity
THIAE_06430	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
THIAE_06435	COG0159	tryptophan synthase activity
THIAE_06440	COG0133	tryptophan synthase activity
THIAE_06445	COG0135	phosphoribosylanthranilate isomerase activity
THIAE_06450	COG0101	tRNA pseudouridine synthase activity
THIAE_06455	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
THIAE_06465	COG0739	heme binding
THIAE_06470	COG0473	3-isopropylmalate dehydrogenase activity
THIAE_06475	COG0066	3-isopropylmalate dehydratase activity
THIAE_06480	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
THIAE_06485	COG0602	queuosine metabolic process
THIAE_06505	COG2205	protein histidine kinase activity
THIAE_06505	COG0784	Response regulator, receiver
THIAE_06510	COG1917	Cupin 2, conserved barrel domain protein
THIAE_06515	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
THIAE_06520	COG0456	acetyltransferase
THIAE_06525	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
THIAE_06530	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
THIAE_06535	COG2890	protein-(glutamine-N5) methyltransferase activity
THIAE_06540	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
THIAE_06570	COG1530	ribonuclease E activity
THIAE_06575	COG0424	maF-like protein
THIAE_06580	COG0442	prolyl-tRNA aminoacylation
THIAE_06605	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
THIAE_06610	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
THIAE_06620	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
THIAE_06625	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
THIAE_06635	COG0717	Belongs to the dCTP deaminase family
THIAE_06640	COG0489	protein tyrosine kinase activity
THIAE_06645	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
THIAE_06645	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
THIAE_06650	COG4657	Part of a membrane complex involved in electron transport
THIAE_06655	COG2878	Part of a membrane complex involved in electron transport
THIAE_06670	COG4659	FMN binding
THIAE_06680	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
THIAE_06695	COG4206	TonB-dependent receptor
THIAE_06720	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
THIAE_06725	COG4681	YaeQ
THIAE_06730	COG4628	conserved protein (DUF2132)
THIAE_06745	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
THIAE_06775	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
THIAE_06840	COG5002	protein histidine kinase activity
THIAE_06855	COG1643	Atp-dependent helicase
THIAE_06860	COG4115	mRNA cleavage
THIAE_06865	COG2161	toxin-antitoxin pair type II binding
THIAE_06875	COG1047	Peptidyl-prolyl cis-trans
THIAE_06885	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
THIAE_06905	COG3706	GGDEF domain
THIAE_06905	COG0745	RESPONSE REGULATOR receiver
THIAE_06910	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
THIAE_06915	COG1074	ATP-dependent DNA helicase activity
THIAE_06920	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
THIAE_06925	COG1671	Belongs to the UPF0178 family
THIAE_06930	COG3012	SEC-C Motif Domain Protein
THIAE_06970	COG3328	transposase activity
THIAE_06985	COG0232	Belongs to the dGTPase family. Type 2 subfamily
THIAE_06990	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
THIAE_07010	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
THIAE_07040	COG0668	transmembrane transport
THIAE_07055	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
THIAE_07060	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
THIAE_07065	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
THIAE_07070	COG0330	HflC and HflK could
THIAE_07075	COG0330	HflC and HflK could
THIAE_07080	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
THIAE_07085	COG1923	regulation of RNA biosynthetic process
THIAE_07090	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
THIAE_07095	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
THIAE_07105	COG0802	atpase or kinase
THIAE_07110	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
THIAE_07120	COG2198	Histidine kinase
THIAE_07120	COG0643	Histidine kinase
THIAE_07140	COG0455	bacterial-type flagellum organization
THIAE_07150	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
THIAE_07155	COG3328	transposase activity
THIAE_07170	COG1987	bacterial-type flagellum assembly
THIAE_07205	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
THIAE_07235	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
THIAE_07245	COG1677	Flagellar hook-basal body complex protein FliE
THIAE_07250	COG2204	response regulator
THIAE_07255	COG3852	Histidine kinase
THIAE_07270	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
THIAE_07285	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
THIAE_07295	COG1028	Short-chain dehydrogenase reductase Sdr
THIAE_07300	COG1083	cytidylyl-transferase
THIAE_07325	COG1011	Hydrolase
THIAE_07345	COG4804	nuclease activity
THIAE_07350	COG2089	acid synthase
THIAE_07360	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
THIAE_07365	COG1088	dTDP-glucose 4,6-dehydratase activity
THIAE_07370	COG0741	lytic transglycosylase activity
THIAE_07375	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
THIAE_07390	COG1706	bacterial-type flagellum-dependent cell motility
THIAE_07395	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
THIAE_07400	COG4786	Flagellar basal body rod
THIAE_07420	COG0527	aspartate kinase activity
THIAE_07425	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
THIAE_07430	COG2137	regulation of response to DNA damage stimulus
THIAE_07435	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
THIAE_07440	COG1546	Belongs to the CinA family
THIAE_07465	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
THIAE_07470	COG3118	belongs to the thioredoxin family
THIAE_07485	COG0189	ligase activity
THIAE_07500	COG0335	large ribosomal subunit rRNA binding
THIAE_07505	COG0336	Belongs to the RNA methyltransferase TrmD family
THIAE_07510	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
THIAE_07515	COG0228	four-way junction DNA binding
THIAE_07520	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
THIAE_07530	COG4536	flavin adenine dinucleotide binding
THIAE_07535	COG0483	inositol monophosphate 1-phosphatase activity
THIAE_07545	COG2857	Cytochrome c1
THIAE_07550	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
THIAE_07555	COG0723	plastoquinol--plastocyanin reductase activity
THIAE_07560	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
THIAE_07565	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
THIAE_07570	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
THIAE_07575	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
THIAE_07580	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
THIAE_07590	COG0842	Transport permease protein
THIAE_07595	COG1131	(ABC) transporter
THIAE_07610	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
THIAE_07615	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
THIAE_07620	COG1127	ABC transporter
THIAE_07635	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
THIAE_07650	COG1137	ATPase activity
THIAE_07660	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
THIAE_07665	COG0564	pseudouridine synthase activity
THIAE_07685	COG0326	Molecular chaperone. Has ATPase activity
THIAE_07695	COG2198	Histidine kinase
THIAE_07695	COG0643	Histidine kinase
THIAE_07700	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
THIAE_07705	COG0590	tRNA wobble adenosine to inosine editing
THIAE_07710	COG0518	GMP synthase (glutamine-hydrolyzing) activity
THIAE_07710	COG0519	Catalyzes the synthesis of GMP from XMP
THIAE_07735	COG0560	Phosphoserine phosphatase
THIAE_07745	COG0811	peptide transport
THIAE_07750	COG0848	biopolymer transport protein
THIAE_07755	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
THIAE_07770	COG3123	guanosine phosphorylase activity
THIAE_07780	COG2814	Major facilitator Superfamily
THIAE_07785	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
THIAE_07795	COG2890	protein-(glutamine-N5) methyltransferase activity
THIAE_07800	COG0521	Mo-molybdopterin cofactor biosynthetic process
THIAE_07805	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
THIAE_07815	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
THIAE_07820	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
THIAE_07825	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
THIAE_07830	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
THIAE_07840	COG0784	Response regulator, receiver
THIAE_07840	COG0835	chemotaxis
THIAE_07865	COG1218	3'(2'),5'-bisphosphate nucleotidase
THIAE_07870	COG0494	nUDIX hydrolase
THIAE_07875	COG1011	Hydrolase
THIAE_07880	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
THIAE_07905	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
THIAE_07915	COG3852	Histidine kinase
THIAE_07920	COG2204	response regulator
THIAE_07925	COG0798	PFAM Bile acid sodium symporter
THIAE_07930	COG3550	peptidyl-serine autophosphorylation
THIAE_07935	COG1396	sequence-specific DNA binding
THIAE_07955	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
THIAE_07970	COG3657	addiction module killer protein
THIAE_07995	COG0778	Nitroreductase
THIAE_08000	COG5002	protein histidine kinase activity
THIAE_08015	COG0745	RESPONSE REGULATOR receiver
THIAE_08020	COG2132	Multicopper oxidase
THIAE_08040	COG5001	Diguanylate cyclase
THIAE_08040	COG4251	negative regulation of phosphorylation
THIAE_08040	COG3706	GGDEF domain
THIAE_08040	COG2203	Gaf domain
THIAE_08045	COG0784	Response regulator, receiver
THIAE_08045	COG2205	protein histidine kinase activity
THIAE_08050	COG5001	Diguanylate cyclase
THIAE_08060	COG0500	methyltransferase
THIAE_08070	COG3030	protein affecting phage T7 exclusion by the F plasmid
THIAE_08075	COG4232	protein-disulfide reductase activity
THIAE_08085	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
THIAE_08095	COG0439	Biotin carboxylase
THIAE_08100	COG2264	protein methyltransferase activity
THIAE_08110	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
THIAE_08115	COG0138	bifunctional purine biosynthesis protein purh
THIAE_08120	COG0151	Belongs to the GarS family
THIAE_08125	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
THIAE_08130	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
THIAE_08140	COG3720	iron ion transport
THIAE_08155	COG4771	TonB-dependent receptor
THIAE_08245	COG0583	DNA-binding transcription factor activity
THIAE_08275	COG1629	transport
THIAE_08275	COG4774	siderophore transport
THIAE_08305	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
THIAE_08310	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
THIAE_08315	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
THIAE_08320	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
THIAE_08330	COG0058	SHG alpha-glucan phosphorylase activity
THIAE_08335	COG0297	glycogen (starch) synthase activity
THIAE_08340	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
THIAE_08355	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
THIAE_08360	COG0837	glucose binding
THIAE_08365	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
THIAE_08370	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
THIAE_08370	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
THIAE_08380	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
THIAE_08380	COG0517	IMP dehydrogenase activity
THIAE_08385	COG1519	Transferase
THIAE_08405	COG1620	l-lactate permease
THIAE_08410	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
THIAE_08430	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
THIAE_08435	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
THIAE_08440	COG1385	rRNA (uridine-N3-)-methyltransferase activity
THIAE_08480	COG3852	Histidine kinase
THIAE_08490	COG1295	ribonuclease BN
THIAE_08495	COG0793	Belongs to the peptidase S41A family
THIAE_08500	COG0640	Transcriptional regulator
THIAE_08510	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
THIAE_08515	COG0772	Belongs to the SEDS family
THIAE_08520	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
THIAE_08525	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
THIAE_08530	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
THIAE_08535	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
THIAE_08550	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
THIAE_08555	COG0275	rRNA processing
THIAE_08560	COG2001	Belongs to the MraZ family
THIAE_08580	COG0792	nuclease activity
THIAE_08585	COG0783	Belongs to the Dps family
THIAE_08590	COG1346	cytolysis
THIAE_08600	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
THIAE_08625	COG0828	Belongs to the bacterial ribosomal protein bS21 family
THIAE_08630	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
THIAE_08635	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
THIAE_08650	COG1968	undecaprenyl-diphosphatase activity
THIAE_08660	COG2239	Acts as a magnesium transporter
THIAE_08670	COG2239	Acts as a magnesium transporter
THIAE_08685	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
THIAE_08695	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
THIAE_08725	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
THIAE_08740	COG2210	Belongs to the sulfur carrier protein TusA family
THIAE_08785	COG0012	GTP binding
THIAE_08790	COG0193	aminoacyl-tRNA hydrolase activity
THIAE_08795	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
THIAE_08800	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
THIAE_08810	COG0268	Binds directly to 16S ribosomal RNA
THIAE_08815	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
THIAE_08820	COG0799	negative regulation of ribosome biogenesis
THIAE_08825	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
THIAE_08830	COG2169	Transcriptional regulator
THIAE_08830	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
THIAE_08840	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
THIAE_08865	COG0495	leucyl-tRNA aminoacylation
THIAE_08900	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
THIAE_08900	COG2755	lipolytic protein G-D-S-L family
THIAE_08925	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
THIAE_08945	COG0004	ammonium transporteR
THIAE_08955	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
THIAE_08965	COG0525	valine-tRNA ligase activity
THIAE_08980	COG4974	Belongs to the 'phage' integrase family
THIAE_09000	COG2945	thiolester hydrolase activity
THIAE_09005	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
THIAE_09035	COG1304	FMN binding
THIAE_09040	COG3425	synthase
THIAE_09060	COG2969	positive regulation of protein catabolic process
THIAE_09065	COG0625	glutathione transferase activity
THIAE_09090	COG0776	regulation of translation
THIAE_09095	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
THIAE_09095	COG0072	phenylalanine-tRNA ligase activity
THIAE_09100	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
THIAE_09105	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
THIAE_09110	COG0291	Belongs to the bacterial ribosomal protein bL35 family
THIAE_09115	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
THIAE_09120	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
THIAE_09125	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
THIAE_09135	COG0446	pyridine nucleotide-disulphide oxidoreductase
THIAE_09145	COG0795	lipopolysaccharide-transporting ATPase activity
THIAE_09155	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
THIAE_09165	COG0745	RESPONSE REGULATOR receiver
THIAE_09185	COG0556	nucleotide-excision repair
THIAE_09215	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
THIAE_09220	COG0840	transmembrane signaling receptor activity
THIAE_09230	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
THIAE_09235	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
THIAE_09250	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
THIAE_09275	COG1982	Orn Lys Arg decarboxylase major
THIAE_09280	COG2205	protein histidine kinase activity
THIAE_09285	COG0745	RESPONSE REGULATOR receiver
THIAE_09300	COG1309	transcriptional regulator
THIAE_09315	COG3328	transposase activity
THIAE_09325	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
THIAE_09330	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
THIAE_09355	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
THIAE_09355	COG2111	Na H antiporter
THIAE_09360	COG1006	Multisubunit Na H antiporter MnhC subunit
THIAE_09365	COG0651	ATP synthesis coupled electron transport
THIAE_09375	COG2212	antiporter activity
THIAE_09380	COG1320	monovalent cation:proton antiporter activity
THIAE_09390	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
THIAE_09390	COG0438	transferase activity, transferring glycosyl groups
THIAE_09400	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
THIAE_09415	COG1611	Belongs to the LOG family
THIAE_09420	COG0513	Belongs to the DEAD box helicase family
THIAE_09425	COG0840	transmembrane signaling receptor activity
THIAE_09430	COG0840	transmembrane signaling receptor activity
THIAE_09440	COG0585	pseudouridine synthase activity
THIAE_09455	COG1454	alcohol dehydrogenase
THIAE_09460	COG2337	Toxic component of a toxin-antitoxin (TA) module
THIAE_09470	COG0210	DNA helicase
THIAE_09490	COG2813	Specifically methylates the guanine in position
THIAE_09540	COG1309	transcriptional regulator
THIAE_09555	COG1538	Outer membrane efflux protein
THIAE_09660	COG2189	Belongs to the N(4) N(6)-methyltransferase family
THIAE_09695	COG0606	chelatase, subunit chli
THIAE_09710	COG0018	arginyl-trna synthetase
THIAE_09730	COG0758	DNA mediated transformation
THIAE_09735	COG0242	peptide deformylase activity
THIAE_09740	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
THIAE_09755	COG5000	phosphorelay sensor kinase activity
THIAE_09760	COG2204	response regulator
THIAE_09765	COG0569	domain protein
THIAE_09815	COG3278	Belongs to the heme-copper respiratory oxidase family
THIAE_09820	COG0131	Imidazoleglycerol-phosphate dehydratase
THIAE_09825	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
THIAE_09830	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
THIAE_09835	COG0107	imidazoleglycerol-phosphate synthase activity
THIAE_09840	COG0140	phosphoribosyl-ATP diphosphatase activity
THIAE_09845	COG0537	adenosine 5'-monophosphoramidase activity
THIAE_09855	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
THIAE_09890	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
THIAE_09900	COG0583	DNA-binding transcription factor activity
THIAE_09965	COG1850	ribulose-bisphosphate carboxylase activity
THIAE_09970	COG3094	Invasion gene expression up-regulator, SirB
THIAE_09975	COG2226	methyltransferase
THIAE_09985	COG1278	Cold shock
THIAE_09995	COG0156	8-amino-7-oxononanoate synthase activity
THIAE_10000	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
THIAE_10005	COG1040	competence protein
THIAE_10010	COG1929	Belongs to the glycerate kinase type-1 family
THIAE_10020	COG1215	transferase activity, transferring glycosyl groups
THIAE_10030	COG0210	DNA helicase
THIAE_10040	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
THIAE_10045	COG0254	rRNA binding
THIAE_10055	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
THIAE_10060	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
THIAE_10065	COG1194	a g-specific adenine glycosylase
THIAE_10070	COG0220	tRNA (guanine-N7-)-methyltransferase activity
THIAE_10080	COG3437	response regulator, receiver
THIAE_10080	COG3850	Histidine kinase
THIAE_10080	COG4999	Histidine kinase
THIAE_10080	COG2205	protein histidine kinase activity
THIAE_10090	COG3706	GGDEF domain
THIAE_10105	COG0037	tRNA processing
THIAE_10110	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
THIAE_10125	COG3437	response regulator, receiver
THIAE_10130	COG0784	Response regulator, receiver
THIAE_10130	COG5002	protein histidine kinase activity
THIAE_10130	COG2205	protein histidine kinase activity
THIAE_10150	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
THIAE_10160	COG2104	thiamine diphosphate biosynthetic process
THIAE_10165	COG2022	thiamine diphosphate biosynthetic process
THIAE_10170	COG1192	Involved in chromosome partitioning
THIAE_10180	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
THIAE_10185	COG2353	YceI-like domain
THIAE_10190	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
THIAE_10200	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
THIAE_10205	COG0355	proton-transporting ATP synthase activity, rotational mechanism
THIAE_10210	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
THIAE_10215	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
THIAE_10220	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
THIAE_10225	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
THIAE_10230	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
THIAE_10235	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
THIAE_10240	COG0356	it plays a direct role in the translocation of protons across the membrane
THIAE_10260	COG1192	Involved in chromosome partitioning
THIAE_10265	COG0357	Ribosomal RNA small subunit methyltransferase G
THIAE_10270	COG0445	tRNA wobble uridine modification
THIAE_10290	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
THIAE_10295	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
THIAE_10295	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
THIAE_10305	COG1528	Iron-storage protein
THIAE_10310	COG4772	TonB-dependent receptor
THIAE_10340	COG0181	hydroxymethylbilane synthase activity
THIAE_10350	COG0165	Argininosuccinate lyase
THIAE_10370	COG2814	Major facilitator Superfamily
THIAE_10375	COG2205	protein histidine kinase activity
THIAE_10375	COG3850	Histidine kinase
THIAE_10375	COG4999	Histidine kinase
THIAE_10375	COG3437	response regulator, receiver
THIAE_10380	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
THIAE_10400	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
THIAE_10405	COG0339	signal peptide processing
THIAE_10425	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
THIAE_10440	COG0730	response to heat
THIAE_10445	COG0706	membrane insertase activity
THIAE_10450	COG0594	ribonuclease P activity
THIAE_10455	COG0230	Belongs to the bacterial ribosomal protein bL34 family
THIAE_10460	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
THIAE_10465	COG0187	DNA topoisomerase II activity
THIAE_10480	COG4191	Histidine kinase
THIAE_10485	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
THIAE_10490	COG0408	coproporphyrinogen oxidase activity
THIAE_10495	COG4783	chaperone-mediated protein folding
THIAE_10500	COG0218	Necessary for normal cell division and for the maintenance of normal septation
THIAE_10505	COG1333	cytochrome c biogenesis protein
THIAE_10510	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
THIAE_10525	COG0778	Nitroreductase
THIAE_10530	COG0583	DNA-binding transcription factor activity
THIAE_10540	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
THIAE_10545	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
THIAE_10550	COG0009	L-threonylcarbamoyladenylate synthase
THIAE_10555	COG4208	sulfate ABC transporter
THIAE_10565	COG3842	ATPase activity
THIAE_10575	COG2304	oxidoreductase activity
THIAE_10595	COG0714	Associated with various cellular activities
THIAE_10600	COG0500	methyltransferase
THIAE_10605	COG2226	methyltransferase
THIAE_10610	COG0583	DNA-binding transcription factor activity
THIAE_10615	COG1741	Belongs to the pirin family
THIAE_10625	COG0741	lytic transglycosylase activity
THIAE_10650	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity