locus-tag	class	description
Thicy_0001	ENOG4105CI4	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity)
Thicy_0002	ENOG4105CZ8	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity)
Thicy_0004	ENOG4107S7U	Sulfide dehydrogenase
Thicy_0005	ENOG4105C46	Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity)
Thicy_0006	ENOG4105CM1	Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity)
Thicy_0007	ENOG4105M00	molybdopterin converting factor, subunit 1
Thicy_0008	ENOG4108ZAF	Molybdopterin
Thicy_0009	ENOG4105CVM	Molybdenum cofactor synthesis domain protein
Thicy_0010	ENOG4108YXW	Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity)
Thicy_0012	ENOG4108HH9	Catalyzes two reactions the first one is the production of beta-formyl glycinamide ribonucleotide (GAR) from formate, ATP and beta GAR
Thicy_0013	ENOG4105DUF	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity)
Thicy_0014	ENOG4106762	Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5- dihydroxy-2,3-pentadione (DPD) (By similarity)
Thicy_0016	ENOG4105CGY	Dna recombination protein
Thicy_0018	ENOG4105C87	Aminotransferase class I and II
Thicy_0019	ENOG4107EXU	Short-chain dehydrogenase reductase Sdr
Thicy_0020	ENOG4105CC8	Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity)
Thicy_0021	ENOG4108JQC	penicillin-binding protein 1A
Thicy_0023	ENOG4105ED0	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity)
Thicy_0024	ENOG4108V82	Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity)
Thicy_0025	ENOG4105CSA	Coproporphyrinogen iii oxidase
Thicy_0027	ENOG4105C1J	atp-dependent rna helicase
Thicy_0035	ENOG4105CUC	YeeE YedE family protein
Thicy_0036	ENOG4105CHH	sulfate transporter
Thicy_0041	ENOG4105VEI	Removes the pyruvyl group from chorismate, with concomitant aromatization of the ring, to provide 4- hydroxybenzoate (4HB) for the ubiquinone pathway (By similarity)
Thicy_0042	ENOG4105CB5	ATP-dependent DNA helicase recG
Thicy_0043	ENOG4105KME	endoribonuclease L-psp
Thicy_0044	ENOG4105CWR	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity)
Thicy_0045	ENOG4105VFG	Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity)
Thicy_0047	ENOG4108Z0R	Transferase
Thicy_0048	ENOG4105E2X	shikimate dehydrogenase
Thicy_0049	ENOG4105D52	delta-aminolevulinic acid dehydratase
Thicy_0050	ENOG4105CCD	The exact function is not known. Can catalyze the reduction of a variety of substrates like dimethyl sulfoxide, trimethylamine N-oxide, phenylmethyl sulfoxide and L-methionine sulfoxide. Cannot reduce cyclic N-oxides. Shows no activity as sulfite oxidase (By similarity)
Thicy_0052	ENOG4105CUV	Homoserine Kinase
Thicy_0053	ENOG4105E9K	Isocitrate dehydrogenase
Thicy_0055	ENOG4108EX3	reductase
Thicy_0056	ENOG4105CGK	Exodeoxyribonuclease III
Thicy_0057	ENOG4105CIY	formyltetrahydrofolate deformylase
Thicy_0058	ENOG4105E0I	Catalyzes the formation of N(4)-acetylcytidine (ac(4)C) at the wobble position of tRNA(Met), by using acetyl-CoA as an acetyl donor and ATP (or GTP) (By similarity)
Thicy_0059	ENOG4105CWG	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34 (By similarity)
Thicy_0064	ENOG4107SA8	fad-dependent pyridine nucleotide-disulfide oxidoreductase
Thicy_0066	ENOG4105CEV	competence damage-inducible protein
Thicy_0067	ENOG4105CBX	hi0933 family
Thicy_0069	ENOG4105KCK	Peptidoglycan-associated lipoprotein
Thicy_0070	ENOG4105EHV	domain protein
Thicy_0072	ENOG4105D8A	3-Deoxy-D-manno-octulosonic-acid transferase
Thicy_0073	ENOG4105CET	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria (By similarity)
Thicy_0074	ENOG4107RJC	Iron-containing alcohol dehydrogenase
Thicy_0075	ENOG4105CF4	DegT DnrJ EryC1 StrS aminotransferase
Thicy_0076	ENOG4108UHA	Essential for recycling GMP and indirectly, cGMP (By similarity)
Thicy_0077	ENOG4105KHV	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity)
Thicy_0078	ENOG4105D49	3-dehydroquinate synthase
Thicy_0079	ENOG4105DSB	aldose 1-epimerase
Thicy_0081	ENOG4105CK4	Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity)
Thicy_0082	ENOG4105VNG	YcgL domain-containing protein
Thicy_0083	ENOG4105CGD	Nad-dependent epimerase dehydratase
Thicy_0084	ENOG4105D4J	Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate
Thicy_0085	ENOG41076HS	cation diffusion facilitator family transporter
Thicy_0088	ENOG4105CV1	Transketolase (EC 2.2.1.1)
Thicy_0089	ENOG4105C17	glyceraldehyde-3-phosphate dehydrogenase
Thicy_0090	ENOG4105BZA	Phosphoglycerate kinase
Thicy_0091	ENOG4105CA9	Pyruvate kinase
Thicy_0092	ENOG4105D2N	Aldolase
Thicy_0096	ENOG4105C8V	SAICAR synthetase
Thicy_0098	ENOG4105DJV	ribulose-phosphate 3-epimerase
Thicy_0099	ENOG4108VXP	Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity)
Thicy_0100	ENOG4105CRQ	synthase (Component I)
Thicy_0101	ENOG4105DDQ	anthranilate synthase
Thicy_0102	ENOG4107QYG	anthranilate phosphoribosyltransferase
Thicy_0103	ENOG4105DK0	Indole-3-glycerol phosphate synthase
Thicy_0104	ENOG4108UKZ	OsmC family
Thicy_0105	ENOG4105X3E	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity)
Thicy_0106	ENOG4105CCX	Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity)
Thicy_0107	ENOG4105C8Y	Acetylornithine aminotransferase
Thicy_0108	ENOG4105CGV	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity)
Thicy_0109	ENOG4105PM1	preprotein translocase subunit SecE
Thicy_0110	ENOG4105E5V	Participates in transcription elongation, termination and antitermination (By similarity)
Thicy_0111	ENOG4108UIK	This protein binds directly to 23S ribosomal RNA (By similarity)
Thicy_0112	ENOG4105C64	Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity)
Thicy_0113	ENOG4108VZM	50s ribosomal protein L10
Thicy_0114	ENOG4105KBC	Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity)
Thicy_0115	ENOG4107QIH	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
Thicy_0116	ENOG4105D27	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
Thicy_0117	ENOG4108UKE	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity)
Thicy_0118	ENOG4108UHY	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity)
Thicy_0119	ENOG4105CEJ	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity)
Thicy_0120	ENOG4105CGV	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity)
Thicy_0121	ENOG4108Z10	Involved in the binding of tRNA to the ribosomes (By similarity)
Thicy_0122	ENOG4105EEE	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity)
Thicy_0123	ENOG4106U5A	One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity)
Thicy_0124	ENOG41080KG	One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity)
Thicy_0125	ENOG4105CFD	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
Thicy_0126	ENOG4105K7S	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity)
Thicy_0127	ENOG4105KAP	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity)
Thicy_0128	ENOG4105CKE	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity)
Thicy_0129	ENOG4108R70	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity)
Thicy_0130	ENOG41083MP	50s ribosomal protein l29
Thicy_0131	ENOG4105K87	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal
Thicy_0132	ENOG4108UNN	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity)
Thicy_0133	ENOG4105KAR	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity)
Thicy_0134	ENOG4105CW6	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
Thicy_0135	ENOG4105VBI	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity)
Thicy_0136	ENOG4108UJY	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity)
Thicy_0137	ENOG4108R5J	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity)
Thicy_0138	ENOG4105K4C	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity)
Thicy_0139	ENOG4108RA9	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity)
Thicy_0140	ENOG4105VPB	50S ribosomal protein L30
Thicy_0141	ENOG4108UZ0	Binds to the 23S rRNA (By similarity)
Thicy_0142	ENOG4105CGG	The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity)
Thicy_0143	ENOG4108Z04	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
Thicy_0144	ENOG4108UHH	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity)
Thicy_0145	ENOG4105G6W	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity)
Thicy_0146	ENOG4105CTF	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
Thicy_0147	ENOG4108ZT0	50S ribosomal protein l17
Thicy_0148	ENOG4105F8V	Hydrolase, tatD family
Thicy_0149	ENOG4105CUZ	uba thif-type nad fad binding protein
Thicy_0151	ENOG4105CU5	Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity)
Thicy_0153	ENOG4106CJB	Phospholipase Carboxylesterase
Thicy_0155	ENOG4105CJS	Phosphopantothenoylcysteine decarboxylase
Thicy_0156	ENOG4105C5U	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity)
Thicy_0160	ENOG4105CVP	deoxyribo-dipyrimidine photolyase
Thicy_0162	ENOG4105EXX	Deoxyribodipyrimidine photolyase-related protein
Thicy_0163	ENOG4107RDB	Major Facilitator
Thicy_0165	ENOG4105EAH	synthase
Thicy_0166	ENOG4105KK9	This protein binds to 23S rRNA in the presence of protein L20 (By similarity)
Thicy_0167	ENOG4105K46	50S ribosomal protein l27
Thicy_0168	ENOG4105C9R	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
Thicy_0169	ENOG4105CGT	Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity)
Thicy_0170	ENOG4108ISG	Major Facilitator
Thicy_0172	ENOG4105C94	Transporter
Thicy_0174	ENOG4105CJ9	Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity)
Thicy_0175	ENOG4105C0N	N-acetylglutamate semialdehyde dehydrogenase
Thicy_0176	ENOG4108YX9	iron--sulfur cluster insertion protein erpA
Thicy_0177	ENOG4105BZN	citrate synthase
Thicy_0178	ENOG4108UM5	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity)
Thicy_0179	ENOG4108UJD	30S ribosomal protein S9
Thicy_0180	ENOG4105BZU	Histidine kinase
Thicy_0182	ENOG4105CVP	deoxyribo-dipyrimidine photolyase
Thicy_0185	ENOG4108NUI	synthase
Thicy_0188	ENOG4107FW0	short-chain dehydrogenase reductase
Thicy_0191	ENOG4105FAV	ABC, transporter
Thicy_0192	ENOG4105FDK	ABC transporter
Thicy_0195	ENOG4105DIW	FeS assembly protein SUFB
Thicy_0196	ENOG4105C3K	feS assembly ATPase SufC
Thicy_0197	ENOG4105JRK	feS assembly protein SufD
Thicy_0199	ENOG4105DFU	Cell wall formation (By similarity)
Thicy_0200	ENOG4105CPF	Cell wall formation (By similarity)
Thicy_0201	ENOG4105K7E	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly (By similarity)
Thicy_0202	ENOG4105CIT	This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity)
Thicy_0203	ENOG4105C7C	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity)
Thicy_0205	ENOG4105CI6	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving
Thicy_0206	ENOG4105C5V	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity)
Thicy_0207	ENOG4108UV6	Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity)
Thicy_0208	ENOG4108ZQD	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity)
Thicy_0210	ENOG4105CAQ	asparagine synthetase
Thicy_0211	ENOG4105M2J	Glutaredoxin
Thicy_0212	ENOG4105DH5	Responsible for the end-turnover of tRNA specifically removes the terminal AMP residue from uncharged tRNA (tRNA-C-C-A). Also appears to be involved in tRNA biosynthesis (By similarity)
Thicy_0213	ENOG4107QZM	n-acetylglutamate synthase
Thicy_0214	ENOG4105C01	Dihydroxy-acid dehydratase
Thicy_0216	ENOG41088H4	Diheme cytochrome SoxA (Sulfur oxidation)
Thicy_0220	ENOG4105ERG	peptidase m48, ste24p
Thicy_0221	ENOG4105VFE	sira family
Thicy_0222	ENOG4105C3Y	UTP-glucose-1-phosphate uridylyltransferase
Thicy_0223	ENOG4107QP8	phosphohexose isomerase
Thicy_0224	ENOG4105C6Y	Udp-glucose 6-dehydrogenase
Thicy_0225	ENOG4106PT6	cdpdiacylglycerol-serine O-phosphatidyltransferase
Thicy_0226	ENOG4105CYQ	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity)
Thicy_0228	ENOG4105KEG	ribosomal-protein-alanine acetyltransferase
Thicy_0229	ENOG4105ECY	inositol monophosphatase
Thicy_0232	ENOG4108ZF1	Transcriptional regulator, BadM Rrf2 family
Thicy_0233	ENOG4108Z4V	iron-sulfur cluster assembly
Thicy_0234	ENOG4108UGX	Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity)
Thicy_0235	ENOG4105C55	Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs
Thicy_0237	ENOG4105CUT	histidyl-tRNA synthetase
Thicy_0239	ENOG4105CNE	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity)
Thicy_0240	ENOG4105DKZ	GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity)
Thicy_0241	ENOG4105CQB	FAD linked oxidase domain protein
Thicy_0242	ENOG4106RE7	Cytochrome
Thicy_0243	ENOG4105N7H	Cytochrome
Thicy_0245	ENOG4105E06	May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity)
Thicy_0246	ENOG41090A4	Pterin carbinolamine dehydratase
Thicy_0247	ENOG4105C2Y	STE24 endopeptidase EC 3.4.24.84
Thicy_0248	ENOG4108RBP	3'-to-5' exoribonuclease specific for small oligoribonucleotides (By similarity)
Thicy_0249	ENOG4105C7K	acetolactate synthase
Thicy_0250	ENOG4108ZP8	Acetolactate synthase small subunit
Thicy_0251	ENOG4105C6M	Alpha-keto-beta-hydroxylacyl reductoisomerase
Thicy_0252	ENOG4105BZ8	glutamate synthase
Thicy_0253	ENOG4105CBC	glutamate synthase
Thicy_0254	ENOG4107R37	Glutamate dehydrogenase
Thicy_0255	ENOG4105CJI	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity)
Thicy_0256	ENOG41082J7	Rhodanese domain protein
Thicy_0258	ENOG4105IX2	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA (By similarity)
Thicy_0259	ENOG4105CSF	NADPH-dependent glycerol-3-phosphate dehydrogenase
Thicy_0260	ENOG4108UIQ	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity)
Thicy_0261	ENOG4107RY0	Catalyzes the conversion of dihydroorotate to orotate (By similarity)
Thicy_0262	ENOG4105DA0	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity)
Thicy_0263	ENOG4105HJX	Biotin- acetyl-CoA-carboxylase ligase
Thicy_0264	ENOG4108194	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis (By similarity)
Thicy_0265	ENOG4108RKI	Necessary for the introduction of cis unsaturation into fatty acids. Catalyzes the dehydration of (3R)-3-hydroxydecanoyl- ACP to E-(2)-decenoyl-ACP and then its isomerization to Z-(3)- decenoyl-ACP. Can catalyze the dehydratase reaction for beta- hydroxyacyl-ACPs with saturated chain lengths up to 16 0, being most active on intermediate chain length (By similarity)
Thicy_0268	ENOG4105CCP	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC)
Thicy_0271	ENOG4106H78	methyltransferase
Thicy_0272	ENOG4108ZEF	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity)
Thicy_0274	ENOG4108VPT	UPF0234 protein
Thicy_0275	ENOG4105CAS	nag kinase
Thicy_0277	ENOG4107QP2	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity)
Thicy_0279	ENOG4105C9X	ppx gppa phosphatase
Thicy_0280	ENOG4105CUU	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity)
Thicy_0281	ENOG4105DSF	transport protein
Thicy_0284	ENOG4108Z1K	This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity)
Thicy_0291	ENOG4105ERD	Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity)
Thicy_0293	ENOG410642E	Short chain dehydrogenase
Thicy_0294	ENOG4105CFB	Gamma-glutamyltranspeptidase (EC 2.3.2.2)
Thicy_0295	ENOG4105KE9	The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity)
Thicy_0298	ENOG4105CD3	dihydroorotase
Thicy_0301	ENOG4105DFA	alanine racemase domain protein
Thicy_0302	ENOG4105CSR	polyphosphate kinase 2
Thicy_0308	ENOG4105C17	glyceraldehyde-3-phosphate dehydrogenase
Thicy_0314	ENOG4105C3B	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity)
Thicy_0315	ENOG4105C0V	Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity)
Thicy_0317	ENOG4105VFQ	Histone family protein nucleoid-structuring protein H-NS
Thicy_0319	ENOG4105CD3	dihydroorotase
Thicy_0320	ENOG4105CXT	aspartate transcarbamylase
Thicy_0321	ENOG4108UK1	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant (By similarity)
Thicy_0322	ENOG4107Y66	Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity)
Thicy_0323	ENOG4108UJU	UPF0301 protein
Thicy_0325	ENOG4105D7Z	glutathione synthase
Thicy_0329	ENOG4105DR1	Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity)
Thicy_0330	ENOG4105W0E	50S ribosomal protein L33
Thicy_0331	ENOG4105KDC	50s ribosomal protein l28
Thicy_0332	ENOG4105W5Q	DNA repair protein (RadC
Thicy_0333	ENOG4105DWV	Homoserine O-trans-acetylase
Thicy_0334	ENOG4105DWV	Homoserine O-trans-acetylase
Thicy_0335	ENOG4108VIA	integral membrane protein
Thicy_0336	ENOG4105II7	pyrroline-5-carboxylate reductase
Thicy_0337	ENOG4105VAS	Could be involved in insertion of integral membrane proteins into the membrane (By similarity)
Thicy_0338	ENOG4105DZA	Converts GTP to 7,8-dihydroneopterin triphosphate (By similarity)
Thicy_0339	ENOG4105CKI	cobalamin synthesis protein
Thicy_0340	ENOG4107RSR	Malate quinone oxidoreductase
Thicy_0342	ENOG4105CPC	Aldo Keto reductase
Thicy_0344	ENOG4105KJP	alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
Thicy_0353	ENOG4105CI6	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving
Thicy_0355	ENOG4105CD8	aminopeptidase N
Thicy_0358	ENOG4105ZIE	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides (By similarity)
Thicy_0360	ENOG4105DFU	Cell wall formation (By similarity)
Thicy_0362	ENOG4105D05	Receptor
Thicy_0363	ENOG4105CNK	Required, probably indirectly, for the hydroxylation of 2-octaprenylphenol to 2-octaprenyl-6-hydroxy-phenol, the fourth step in ubiquinone biosynthesis (By similarity)
Thicy_0365	ENOG4105DDZ	Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity)
Thicy_0367	ENOG4105C4N	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis (By similarity)
Thicy_0369	ENOG4105CR7	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA (By similarity)
Thicy_0370	ENOG4105E4Z	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity)
Thicy_0373	ENOG4108R5P	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery (By similarity)
Thicy_0376	ENOG4105C2Z	ATP-dependent CLP protease ATP-binding subunit
Thicy_0377	ENOG4108GAE	asmA family
Thicy_0384	ENOG4105DZ2	Transcriptional regulator
Thicy_0387	ENOG4105DSS	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity)
Thicy_0388	ENOG4105EHG	Permease protein
Thicy_0389	ENOG4108IPX	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system (By similarity)
Thicy_0390	ENOG4105C12	Phosphoribosylglycinamide synthetase
Thicy_0391	ENOG4105DC1	bifunctional purine biosynthesis protein purh
Thicy_0392	ENOG4105VY0	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters (By similarity)
Thicy_0393	ENOG4105CEH	Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity)
Thicy_0394	ENOG4105F59	Methylates ribosomal protein L11 (By similarity)
Thicy_0395	ENOG4105CER	acetyl-CoA carboxylase biotin carboxylase
Thicy_0396	ENOG4105KM4	Acetyl-CoA carboxylase, biotin carboxyl carrier protein
Thicy_0397	ENOG4108Z38	Catalyzes a trans-dehydration via an enolate intermediate (By similarity)
Thicy_0398	ENOG4105CSG	Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps (By similarity)
Thicy_0399	ENOG4105FS0	cytoplasmic membrane protein
Thicy_0404	ENOG4105FE9	pseudouridine synthase
Thicy_0407	ENOG4105CGB	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system (By similarity)
Thicy_0415	ENOG4105CGB	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system (By similarity)
Thicy_0416	ENOG4105E0C	molybdate abc transporter
Thicy_0417	ENOG4108S6J	ABC transporter, periplasmic molybdate-binding protein
Thicy_0418	ENOG4105F4R	Transcriptional regulator mode
Thicy_0419	ENOG41061P8	Persistence to inhibition of murein or DNA biosynthesis regulatory protein
Thicy_0420	ENOG4105CAF	HipA N-terminal domain protein
Thicy_0421	ENOG4105D6J	arsenicaL-resistance protein
Thicy_0422	ENOG4105C1W	two component, sigma54 specific, transcriptional regulator, Fis family
Thicy_0423	ENOG4105BZU	Histidine kinase
Thicy_0427	ENOG4105C5H	ABC transporter
Thicy_0428	ENOG4107USA	Thioredoxin
Thicy_0429	ENOG4107Y3D	HAD-superfamily hydrolase subfamily IA variant 3
Thicy_0430	ENOG4105M6F	mutator MutT protein
Thicy_0431	ENOG4108RNI	3'(2')5'-bisphosphate nucleotidase
Thicy_0432	ENOG4105CDM	Glutamate-1-semialdehyde aminotransferase
Thicy_0433	ENOG41085GJ	domain protein
Thicy_0434	ENOG4107QX9	Thiol disulfide interChange protein
Thicy_0435	ENOG4105E66	phosphoriboisomerase A
Thicy_0437	ENOG4105C6P	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity)
Thicy_0438	ENOG4108RIR	Molybdenum cofactor biosynthesis protein
Thicy_0439	ENOG4105C76	Specifically methylates the 50S ribosomal protein L3 on a specific glutamine residue (By similarity)
Thicy_0440	ENOG4105D10	5-enolpyruvylshikimate-3-phosphate phospholyase
Thicy_0441	ENOG4105D8G	Major Facilitator superfamily
Thicy_0443	ENOG4105NBK	UPF0345 protein
Thicy_0445	ENOG4105C31	Tryptophanyl-tRNA synthetase
Thicy_0446	ENOG41067XB	TonB family
Thicy_0447	ENOG4105M15	transport protein ExbD
Thicy_0448	ENOG4105M8K	biopolymer transport protein
Thicy_0450	ENOG4105EAC	phosphoserine phosphatase
Thicy_0454	ENOG4105CP4	Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity)
Thicy_0455	ENOG4105CM0	Catalyzes the synthesis of GMP from XMP (By similarity)
Thicy_0457	ENOG4108Z6B	deaminase
Thicy_0458	ENOG4105CJX	Molecular chaperone. Has ATPase activity (By similarity)
Thicy_0459	ENOG4108V1T	peptidylprolyl cis-trans isomerase
Thicy_0460	ENOG4105D3G	Pseudouridine synthase
Thicy_0462	ENOG41080QH	sigma 54 modulation protein ribosomal protein S30EA
Thicy_0463	ENOG4108IUZ	ABC transporter
Thicy_0466	ENOG4108Z4R	3-deoxy-d-manno-octulosonate 8-phosphate phosphatase
Thicy_0469	ENOG4105DHJ	ABC, transporter
Thicy_0470	ENOG4105CY3	ABC transporter, permease
Thicy_0471	ENOG4107PE3	Mammalian cell entry related domain protein
Thicy_0474	ENOG4105DA5	(ABC) transporter
Thicy_0475	ENOG4105E3A	(ABC) transporter
Thicy_0477	ENOG4105CDF	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity)
Thicy_0478	ENOG4105E21	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity)
Thicy_0479	ENOG4105CEK	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity)
Thicy_0480	ENOG4105CIH	Imidazole acetol-phosphate transaminase
Thicy_0481	ENOG4107QNR	UPF0135 protein
Thicy_0482	ENOG4108R5F	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity)
Thicy_0483	ENOG4105DJ5	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity)
Thicy_0484	ENOG4105EIX	cytochrome c1
Thicy_0485	ENOG4105DNJ	May play a role in the repair of endogenous alkylation damage (By similarity)
Thicy_0486	ENOG4105ECY	inositol monophosphatase
Thicy_0487	ENOG4108JU6	CBS domain protein
Thicy_0489	ENOG4105CB9	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
Thicy_0490	ENOG4105K5M	30s ribosomal protein S16
Thicy_0491	ENOG4108ZR6	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity)
Thicy_0492	ENOG4105D6X	Specifically methylates guanosine-37 in various tRNAs (By similarity)
Thicy_0493	ENOG4108YY1	This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity)
Thicy_0496	ENOG4105D9I	Responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6 (By similarity)
Thicy_0500	ENOG4105D86	that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity)
Thicy_0501	ENOG4107TH8	cina domain protein
Thicy_0502	ENOG4105C68	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity)
Thicy_0503	ENOG4105Y3E	Modulates RecA activity (By similarity)
Thicy_0504	ENOG4105CIM	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity)
Thicy_0505	ENOG4105CFH	Aspartokinase
Thicy_0506	ENOG4105EH2	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity)
Thicy_0507	ENOG4105K8N	protein family UPF0079, ATPase
Thicy_0508	ENOG4105C5C	n-acetylmuramoyl-l-alanine amidase
Thicy_0509	ENOG4105DC6	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity)
Thicy_0510	ENOG4105DKX	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity)
Thicy_0511	ENOG4105KW8	RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity)
Thicy_0512	ENOG4105C1N	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity)
Thicy_0513	ENOG4107QJR	hflk protein
Thicy_0514	ENOG4105EPW	hflc protein
Thicy_0516	ENOG4105C49	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine (By similarity)
Thicy_0517	ENOG4105C91	Plays an important role in the de novo pathway of purine nucleotide biosynthesis
Thicy_0520	ENOG4105D64	Mechanosensitive ion channel
Thicy_0522	ENOG4105C20	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity)
Thicy_0523	ENOG4105C4Q	deoxyguanosinetriphosphate triphosphohydrolase-like protein
Thicy_0524	ENOG4108UPT	UPF0178 protein
Thicy_0525	ENOG4107QYX	exodeoxyribonuclease v alpha
Thicy_0526	ENOG4107QKA	exodeoxyribonuclease V beta
Thicy_0527	ENOG4105DSY	exodeoxyribonuclease V, gamma
Thicy_0528	ENOG4105CN0	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity)
Thicy_0539	ENOG4105MZU	cell filamentation protein
Thicy_0541	ENOG4105DZR	Type I site-specific deoxyribonuclease
Thicy_0545	ENOG4105NDF	NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity)
Thicy_0548	ENOG4105VQU	rdd domain containing protein
Thicy_0549	ENOG4105C3H	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity)
Thicy_0557	ENOG4105FBQ	ATPase associated with various cellular activities aaa_5
Thicy_0559	ENOG4106TCE	
Thicy_0561	ENOG4107RZZ	dna polymerase iii epsilon subunit
Thicy_0562	ENOG4108YZY	peptidylprolyl cis-trans isomerase
Thicy_0564	ENOG4105CQ7	ATP-dependent helicase
Thicy_0566	ENOG4107QKV	phosphomannomutase
Thicy_0571	ENOG4105JKQ	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity)
Thicy_0572	ENOG41068B1	Cob-I-yrinic acid a,c-diamide adenosyltransferase
Thicy_0573	ENOG4105EXZ	Involved in the regulation of ptsG expression by binding and inactivating Mlc (By similarity)
Thicy_0574	ENOG4105VYA	Uncharacterized conserved protein (DUF2132)
Thicy_0575	ENOG4108VWS	Yaeq family
Thicy_0578	ENOG4105CHI	Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB (By similarity)
Thicy_0581	ENOG4105CSM	endonuclease III
Thicy_0583	ENOG4108UQQ	Electron transport complex
Thicy_0584	ENOG4105D6A	Electron transport complex
Thicy_0586	ENOG4108R3D	Electron transport complex
Thicy_0587	ENOG4105DGN	Electron transport complex
Thicy_0588	ENOG4105CKH	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity)
Thicy_0589	ENOG4105D1F	ATP-binding protein
Thicy_0590	ENOG4105DHP	deoxycytidine triphosphate deaminase
Thicy_0592	ENOG4108V3E	phosphoribosylglycinamide formyltransferase
Thicy_0593	ENOG4105CXB	phosphoribosylaminoimidazole synthetase
Thicy_0596	ENOG4107ZT5	Thiol disulfide interchange protein
Thicy_0601	ENOG4105C90	Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity)
Thicy_0602	ENOG4108Z03	MAF-like protein
Thicy_0603	ENOG4105C03	ribonuclease
Thicy_0604	ENOG4105D06	uba thif-type nad fad binding protein
Thicy_0605	ENOG4105EQY	Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity)
Thicy_0606	ENOG4105C8K	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity)
Thicy_0607	ENOG4105C7E	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity)
Thicy_0609	ENOG4108JPW	Aminotransferase
Thicy_0610	ENOG4108Z6K	Catalyzes the circularization of gamma-N-acetyl- alpha,gamma-diaminobutyric acid (ADABA) to ectoine (1,4,5,6- tetrahydro-2-methyl-4-pyrimidine carboxylic acid), which is an excellent osmoprotectant (By similarity)
Thicy_0611	ENOG4105BZU	Histidine kinase
Thicy_0613	ENOG4105C24	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
Thicy_0616	ENOG4105CQI	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity)
Thicy_0618	ENOG4105C0C	Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity)
Thicy_0619	ENOG4105DR5	peptidase
Thicy_0621	ENOG4105DI7	Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity)
Thicy_0622	ENOG4108ZGB	N-(5'-phosphoribosyl)anthranilate isomerase
Thicy_0623	ENOG4105CG0	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity)
Thicy_0624	ENOG4105F6H	The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity)
Thicy_0625	ENOG4107QTG	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA (By similarity)
Thicy_0626	ENOG4105DPM	folylpolyglutamate synthase Dihydrofolate synthase
Thicy_0628	ENOG4105CBA	glutamine phosphoribosylpyrophosphate amidotransferase
Thicy_0629	ENOG4105C28	cystathionine
Thicy_0630	ENOG4105HBR	Rna-binding protein
Thicy_0631	ENOG4105F7M	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit (By similarity)
Thicy_0632	ENOG4105C3H	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity)
Thicy_0633	ENOG4105EEI	dihydropteroate synthase
Thicy_0634	ENOG4107QJF	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity)
Thicy_0635	ENOG4105CP7	Triose-phosphate isomerase
Thicy_0636	ENOG4107EJC	Preprotein translocase subunit SecG
Thicy_0637	ENOG4105KWU	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
Thicy_0638	ENOG4105ES3	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
Thicy_0639	ENOG4105CYU	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
Thicy_0640	ENOG4105CQV	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
Thicy_0642	ENOG4107QIZ	NADH dehydrogenase
Thicy_0644	ENOG4105CMZ	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone (By similarity)
Thicy_0645	ENOG4105P3U	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
Thicy_0646	ENOG4105DF2	NADH dehydrogenase subunit j
Thicy_0647	ENOG4105M5H	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
Thicy_0648	ENOG4105D65	subunit l
Thicy_0649	ENOG4105C8S	subunit m
Thicy_0650	ENOG4105CNR	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
Thicy_0652	ENOG4107QKV	phosphomannomutase
Thicy_0653	ENOG4108YZY	peptidylprolyl cis-trans isomerase
Thicy_0654	ENOG4108YXA	Membrane
Thicy_0655	ENOG4105C5H	ABC transporter
Thicy_0658	ENOG4105DEA	Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation
Thicy_0659	ENOG4105CCQ	Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity)
Thicy_0660	ENOG4105CHN	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity)
Thicy_0661	ENOG4105C6P	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity)
Thicy_0662	ENOG4105EZE	Cupin 4 family protein
Thicy_0663	ENOG4107QTF	adenylosuccinate lyase
Thicy_0667	ENOG4105CC5	ABC transporter
Thicy_0668	ENOG4105CC5	ABC transporter
Thicy_0669	ENOG4105DIK	(ABC) transporter
Thicy_0670	ENOG4105DSE	periplasmic solute binding protein
Thicy_0672	ENOG4105CUX	Signal transduction histidine kinase
Thicy_0673	ENOG4105C1W	two component, sigma54 specific, transcriptional regulator, Fis family
Thicy_0674	ENOG4108YZA	Nitrogen regulatory protein pii
Thicy_0675	ENOG4105DJ4	phosphatidylserine decarboxylase
Thicy_0676	ENOG4105CDH	Citrulline--aspartate ligase
Thicy_0677	ENOG4108ZAI	phosphatidylglycerophosphatase a
Thicy_0679	ENOG4105CK2	sodium dicarboxylate symporter
Thicy_0680	ENOG4105F10	Catalyzes the hydrolysis of the pyrophosphate bond of UDP-2,3-diacylglucosamine to yield 2,3-diacylglucosamine 1- phosphate (lipid X) and UMP (By similarity)
Thicy_0681	ENOG4108R5K	PPIases accelerate the folding of proteins (By similarity)
Thicy_0683	ENOG4105CX6	glutaminyL-tRNA synthetase
Thicy_0684	ENOG4105C8N	cysteinyl-tRNA synthetase
Thicy_0685	ENOG4107SC1	transglycosylase
Thicy_0686	ENOG4105E9H	Lytic Murein transglycosylase
Thicy_0687	ENOG4108RW0	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity)
Thicy_0689	ENOG4108UMW	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity)
Thicy_0691	ENOG4106SNF	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
Thicy_0692	ENOG4105C34	Pseudouridine synthase
Thicy_0693	ENOG4105DBW	Multi-copper polyphenol oxidoreductase laccase
Thicy_0694	ENOG4105D18	nicotinate-nucleotide pyrophosphorylase
Thicy_0695	ENOG4108VBV	N-Acetylmuramoyl-L-alanine amidase
Thicy_0696	ENOG4105MHQ	Low-potential electron donor to a number of redox enzymes (By similarity)
Thicy_0698	ENOG4105EJF	Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity)
Thicy_0699	ENOG4105DAQ	Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity)
Thicy_0700	ENOG4107QSN	dihydrolipoamide acetyltransferase
Thicy_0701	ENOG4107QN2	dihydrolipoyl dehydrogenase
Thicy_0702	ENOG4108W1A	pseudouridine synthase
Thicy_0703	ENOG4108ZZ3	UPF0260 protein
Thicy_0705	ENOG4105DDY	UPF0142 protein ycaO
Thicy_0707	ENOG4107QM9	Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (By similarity)
Thicy_0708	ENOG4105D3U	Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity)
Thicy_0709	ENOG4105C8D	Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity)
Thicy_0710	ENOG4105CXR	Phospho-2-dehydro-3-deoxyoctonate aldolase
Thicy_0711	ENOG4105C70	Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity)
Thicy_0712	ENOG4105XX3	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic (By similarity)
Thicy_0715	ENOG4105E26	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity)
Thicy_0716	ENOG4108UM1	dedA family
Thicy_0718	ENOG4105CHM	Aminotransferase
Thicy_0719	ENOG4105D6E	homoserine dehydrogenase
Thicy_0721	ENOG4107QID	Threonine synthase
Thicy_0722	ENOG4105C2R	Single-stranded-DNA-specific exonuclease (RecJ)
Thicy_0724	ENOG4106F3G	Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5- dihydroxy-2-cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon (By similarity)
Thicy_0725	ENOG4108V7X	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
Thicy_0726	ENOG4107S75	HAD-superfamily hydrolase subfamily IA variant 3
Thicy_0727	ENOG4107UUG	Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity)
Thicy_0729	ENOG4107S5T	Carbohydrate kinase
Thicy_0730	ENOG4105CDB	Required for chromosome condensation and partitioning (By similarity)
Thicy_0732	ENOG4105C77	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity)
Thicy_0733	ENOG4105N42	UPF0307 protein
Thicy_0736	ENOG4105HDK	L-asparaginase
Thicy_0737	ENOG4105DS7	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity)
Thicy_0738	ENOG4105K9H	YciI-like protein
Thicy_0739	ENOG4107835	probably involved in intracellular septation (By similarity)
Thicy_0740	ENOG4105DB7	PHP domain protein
Thicy_0741	ENOG4107RTD	sua5 ycio yrdc ywlc family protein
Thicy_0742	ENOG4108Z4T	Peptidase M50
Thicy_0743	ENOG4108KVX	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves (By similarity)
Thicy_0744	ENOG4105K8I	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity)
Thicy_0745	ENOG4105FE9	pseudouridine synthase
Thicy_0748	ENOG4105C6T	cysteine synthase
Thicy_0750	ENOG41080ZE	Adenylate cyclase
Thicy_0753	ENOG4105C7Q	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity)
Thicy_0757	ENOG4105CWR	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity)
Thicy_0758	ENOG4105KQ5	peptidylprolyl cis-trans isomerase
Thicy_0760	ENOG4105CII	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity)
Thicy_0764	ENOG41067CV	Integrase
Thicy_0776	ENOG4105K5B	UPF0225 protein
Thicy_0779	ENOG4105DG7	nitrate ABC transporter
Thicy_0780	ENOG4105D7T	ABC transporter
Thicy_0781	ENOG4108IFG	nitrite reductase, (NAD(P)H)
Thicy_0782	ENOG4107QZF	nitrite reductase NADPH large subunit
Thicy_0785	ENOG4105CB8	Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity)
Thicy_0787	ENOG4105CVM	Molybdenum cofactor synthesis domain protein
Thicy_0788	ENOG4105C6R	Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity)
Thicy_0789	ENOG4107EER	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity)
Thicy_0792	ENOG4105CEH	Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity)
Thicy_0793	ENOG4107SVC	Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity)
Thicy_0793	ENOG4107SVC	Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity)
Thicy_0796	ENOG4105DTW	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity)
Thicy_0798	ENOG4105DPZ	Two component transcriptional regulator (Winged helix family
Thicy_0803	ENOG41087AY	ADP-Ribose pyrophosphatase
Thicy_0804	ENOG4105CJ4	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity)
Thicy_0805	ENOG4105CDU	Replicative dna helicase
Thicy_0806	ENOG4105K9Q	Binds to the 23S rRNA (By similarity)
Thicy_0808	ENOG4105VH8	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity)
Thicy_0809	ENOG4108ZDX	Binds together with S18 to 16S ribosomal RNA (By similarity)
Thicy_0810	ENOG4106EG9	Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) (By similarity)
Thicy_0812	ENOG41080YA	This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity)
Thicy_0813	ENOG4105CAV	thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity)
Thicy_0814	ENOG4105CAT	Cytidine monophosphate kinase
Thicy_0815	ENOG4105CMY	5-enolpyruvylshikimate-3-phosphate synthase
Thicy_0817	ENOG4105CIH	Imidazole acetol-phosphate transaminase
Thicy_0818	ENOG4105CQC	Prephenate dehydratase
Thicy_0819	ENOG4107QM1	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity)
Thicy_0820	ENOG4105C24	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
Thicy_0821	ENOG4107RFD	Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity)
Thicy_0822	ENOG4108VXP	Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity)
Thicy_0823	ENOG4105CHR	reductase
Thicy_0826	ENOG4105BZM	domain protein
Thicy_0827	ENOG4105CRK	lysyL-tRNA synthetase
Thicy_0832	ENOG4105CHH	sulfate transporter
Thicy_0834	ENOG4107QIK	phosphoribosylformylglycinamidine synthase
Thicy_0836	ENOG4105CDP	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity)
Thicy_0837	ENOG4108YXY	alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
Thicy_0838	ENOG4108IAB	Phoh family
Thicy_0839	ENOG4105KT5	UmuD protein
Thicy_0841	ENOG4105CQ3	Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity)
Thicy_0845	ENOG4105VRT	cytoplasmic protein
Thicy_0854	ENOG4105C2T	Binding-protein-dependent transport systems, inner membrane component
Thicy_0855	ENOG4105CJM	Binding-protein-dependent transport systems, inner membrane component
Thicy_0857	ENOG4105CSJ	Enoyl- acyl-carrier-protein reductase NADH
Thicy_0859	ENOG4105C62	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity)
Thicy_0860	ENOG4105K77	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity)
Thicy_0862	ENOG41088CC	tellurite resistance protein tehB
Thicy_0863	ENOG4105D0T	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity)
Thicy_0864	ENOG4105KG7	Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity)
Thicy_0865	ENOG4107QHU	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity)
Thicy_0866	ENOG4105CHV	Transcription elongation factor NusA
Thicy_0867	ENOG4105K7D	Required for maturation of 30S ribosomal subunits (By similarity)
Thicy_0872	ENOG4108IQF	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity)
Thicy_0873	ENOG4105C0B	DNA polymerase III (alpha subunit)
Thicy_0874	ENOG4108R4Z	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine (By similarity)
Thicy_0877	ENOG4105C00	Succinate dehydrogenase (Flavoprotein subunit)
Thicy_0878	ENOG4105E33	succinate dehydrogenase
Thicy_0880	ENOG4105K9U	however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity)
Thicy_0881	ENOG4105KJV	Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity)
Thicy_0882	ENOG4105CSZ	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate (By similarity)
Thicy_0883	ENOG41071DT	Involved in DNA repair and RecF pathway recombination (By similarity)
Thicy_0884	ENOG4105CWT	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity)
Thicy_0885	ENOG4108ZBM	Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity)
Thicy_0886	ENOG4105C3F	Signal peptidase i
Thicy_0887	ENOG4105C4S	Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity)
Thicy_0888	ENOG4105C0H	protease
Thicy_0890	ENOG4108IYU	L-aspartate oxidase
Thicy_0895	ENOG41084HI	prevent-host-death family
Thicy_0901	ENOG4105VC4	domain protein
Thicy_0904	ENOG4105M0J	Toxic component of a toxin-antitoxin (TA) module. A
Thicy_0905	ENOG4105VGJ	Virulence-associated protein
Thicy_0906	ENOG4105CMR	udp-glucose 4-epimerase
Thicy_0908	ENOG4107ZIC	Glycerol-3-phosphate cytidylyltransferase
Thicy_0909	ENOG4105CMR	udp-glucose 4-epimerase
Thicy_0923	ENOG4105DF3	Catalyzes the retro-aldol cleavage of 4-hydroxy-2- oxopentanoate to pyruvate and acetaldehyde. Is involved in the meta-cleavage pathway for the degradation of aromatic compounds (By similarity)
Thicy_0924	ENOG4108QXE	glycerophosphoryl diester phosphodiesterase
Thicy_0925	ENOG4107SJB	teichoic acid biosynthesis
Thicy_0927	ENOG4108ZEF	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity)
Thicy_0939	ENOG4105D16	lipopolysaccharide heptosyltransferase i
Thicy_0943	ENOG4105D16	lipopolysaccharide heptosyltransferase i
Thicy_0946	ENOG4105CUI	Catalyzes the interconversion between ADP-D-glycero- beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose (By similarity)
Thicy_0949	ENOG4105BZ1	(ABC) transporter
Thicy_0954	ENOG41081QV	Universal stress protein
Thicy_0955	ENOG41072GX	Peptidase M22 Glycoprotease
Thicy_0956	ENOG4105DVT	helicase
Thicy_0957	ENOG4105YK5	50S ribosomal protein L36
Thicy_0958	ENOG4108UH2	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity)
Thicy_0959	ENOG4105D0V	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity)
Thicy_0960	ENOG4105DAF	Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity)
Thicy_0961	ENOG4108YXN	Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity)
Thicy_0962	ENOG4105D7M	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity)
Thicy_0963	ENOG4108RFI	Molecular chaperone that interacts specifically with outer membrane proteins, thus maintaining the solubility of early folding intermediates during passage through the periplasm (By similarity)
Thicy_0964	ENOG4105E1Z	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
Thicy_0965	ENOG4105DZP	Membrane-associated zinc metalloprotease
Thicy_0966	ENOG4105KNE	Phosphatidate cytidylyltransferase
Thicy_0967	ENOG4105CR3	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity)
Thicy_0968	ENOG4108VCV	Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity)
Thicy_0969	ENOG4105C41	Catalyzes the reversible phosphorylation of UMP to UDP (By similarity)
Thicy_0970	ENOG4105CU7	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity)
Thicy_0971	ENOG4105CE9	30S ribosomal protein S2
Thicy_0972	ENOG4105CA1	Removes the N-terminal methionine from nascent proteins (By similarity)
Thicy_0973	ENOG4105E1P	Modifies, by uridylylation or deuridylylation the PII (GlnB) regulatory protein (By similarity)
Thicy_0976	ENOG4105C1B	dTDP-glucose 4-6-dehydratase
Thicy_0978	ENOG4108URP	Dtdp-4-dehydrorhamnose 3,5-epimerase
Thicy_0979	ENOG4105CGR	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity)
Thicy_0980	ENOG4105WMR	Protein CrcB homolog
Thicy_0981	ENOG4105D1H	recombination factor protein RarA
Thicy_0982	ENOG4107Y7W	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane) (By similarity)
Thicy_0983	ENOG4105CNU	cell division protein FtsK
Thicy_0984	ENOG4105C3M	thioredoxin reductase
Thicy_0985	ENOG4105C8A	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP (By similarity)
Thicy_0986	ENOG4107RAB	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity)
Thicy_0987	ENOG4107QN8	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity)
Thicy_0988	ENOG4105VIE	preprotein translocase, subunit YajC
Thicy_0989	ENOG4105C6U	Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity)
Thicy_0990	ENOG4105E2N	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity)
Thicy_0999	ENOG4108RTD	type II secretion system protein K
Thicy_1000	ENOG4108WWZ	General secretion pathway protein J
Thicy_1003	ENOG4108VAU	general secretion pathway protein G
Thicy_1004	ENOG4105D7Q	type ii secretion system
Thicy_1005	ENOG4107QHF	type ii secretion system protein e
Thicy_1006	ENOG4105GVR	general secretion pathway protein D
Thicy_1007	ENOG4108XKW	General secretion pathway protein C
Thicy_1008	ENOG4108HW8	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity)
Thicy_1010	ENOG4105CNG	UPF0061 protein
Thicy_1011	ENOG4106XY2	Folate-binding protein involved in regulating the level of ATP-DnaA and in the modification of some tRNAs. It is probably a key factor in regulatory networks that act via tRNA modification, such as initiation of chromosomal replication (By similarity)
Thicy_1014	ENOG4105FD2	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity)
Thicy_1016	ENOG4105KCK	Peptidoglycan-associated lipoprotein
Thicy_1017	ENOG4107R6Y	Involved in the TonB-independent uptake of proteins (By similarity)
Thicy_1019	ENOG4105M8F	Biopolymer transport protein exbD tolR
Thicy_1020	ENOG4105E02	MotA TolQ exbB proton channel
Thicy_1021	ENOG4105CKJ	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity)
Thicy_1022	ENOG4105KA4	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity)
Thicy_1023	ENOG4105NHU	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group (By similarity)
Thicy_1025	ENOG4105D0I	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity)
Thicy_1026	ENOG4105C9M	aspartyl-trna synthetase
Thicy_1028	ENOG4105E1F	short-chain dehydrogenase reductase
Thicy_1029	ENOG4105CTB	Polyprenyl synthetase
Thicy_1033	ENOG4105E99	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity)
Thicy_1035	ENOG4105CG2	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity)
Thicy_1036	ENOG4107YIM	Involved in the transcription termination process (By similarity)
Thicy_1037	ENOG4108UTT	Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity)
Thicy_1040	ENOG4105D1W	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity)
Thicy_1041	ENOG4108Z11	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity)
Thicy_1042	ENOG4105C65	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity)
Thicy_1043	ENOG4105C5H	ABC transporter
Thicy_1044	ENOG4105BZU	Histidine kinase
Thicy_1046	ENOG4105WH1	Two component transcriptional regulator luxr family
Thicy_1047	ENOG4105C9Q	fumarate hydratase class II
Thicy_1048	ENOG41080RH	Thioredoxin
Thicy_1049	ENOG4105DKQ	ROK family
Thicy_1050	ENOG4105ED9	Protein of unknown function (DUF455)
Thicy_1052	ENOG4108UKH	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity)
Thicy_1053	ENOG4105CU6	carbamoyl-phosphate synthetase ammonia chain
Thicy_1054	ENOG4105C1M	carbamoyl-phosphate synthetase glutamine chain
Thicy_1055	ENOG4105DUK	Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity)
Thicy_1056	ENOG4105BZ5	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity)
Thicy_1057	ENOG4105CFG	Acts as a chaperone (By similarity)
Thicy_1058	ENOG4105K90	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
Thicy_1059	ENOG4105F91	Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity)
Thicy_1060	ENOG4105C4F	May be involved in recombinational repair of damaged DNA (By similarity)
Thicy_1061	ENOG41090R7	Ferric uptake
Thicy_1062	ENOG4105YRI	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity)
Thicy_1063	ENOG4105VDB	UPF0125 protein
Thicy_1064	ENOG4108Z1B	Cyclase dehydrase
Thicy_1065	ENOG4108UH4	Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity)
Thicy_1066	ENOG4108UJV	acyl-CoA thioesterase i
Thicy_1067	ENOG4108I0Y	(ABC) transporter
Thicy_1069	ENOG4105C7B	Threonine dehydratase
Thicy_1076	ENOG4105C5H	ABC transporter
Thicy_1077	ENOG4105CQU	Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity)
Thicy_1079	ENOG4105EN6	Membrane
Thicy_1080	ENOG4108JA2	transcriptioN-repair coupling factor
Thicy_1082	ENOG4105VJP	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell (By similarity)
Thicy_1083	ENOG4107QMS	site-determining protein
Thicy_1084	ENOG4105K7U	Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization (By similarity)
Thicy_1085	ENOG4105IPS	esterase
Thicy_1087	ENOG4105CET	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria (By similarity)
Thicy_1088	ENOG4105W49	UPF0434 protein
Thicy_1089	ENOG4105CHD	Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) (By similarity)
Thicy_1095	ENOG4108EQH	DNA internalization-related competence protein ComEC Rec2
Thicy_1097	ENOG4105DAN	ATP-dependent protease
Thicy_1098	ENOG4105K6H	D-cysteine desulfhydrase
Thicy_1102	ENOG4105C2Z	ATP-dependent CLP protease ATP-binding subunit
Thicy_1103	ENOG4105KAE	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation (By similarity)
Thicy_1104	ENOG4108R99	pseudouridine synthase
Thicy_1105	ENOG4105CCJ	Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity)
Thicy_1106	ENOG41075W9	High frequency lysogenization protein HflD homolog
Thicy_1107	ENOG4107MKT	Stringent starvation protein a
Thicy_1108	ENOG4105K5D	4fe-4S ferredoxin iroN-sulfur binding
Thicy_1109	ENOG4105CFP	Peptidase U32
Thicy_1111	ENOG4105CBM	Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 (By similarity)
Thicy_1114	ENOG4105DMJ	Catalyzes the transfer of an acetyl group from acetyl- CoA to tetrahydrodipicolinate (By similarity)
Thicy_1115	ENOG4105KUZ	arsenate reductase
Thicy_1116	ENOG4105C9Y	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity)
Thicy_1119	ENOG4105C8J	)-transporter
Thicy_1121	ENOG4107QPA	Cleaves GlcNAc linked beta-1,4 to MurNAc tripeptides (By similarity)
Thicy_1122	ENOG4105C2T	Binding-protein-dependent transport systems, inner membrane component
Thicy_1123	ENOG4105CJM	Binding-protein-dependent transport systems, inner membrane component
Thicy_1126	ENOG4105CH8	Succinyl-CoA ligase ADP-forming subunit alpha
Thicy_1127	ENOG4105CMV	Succinyl-CoA synthetase subunit beta
Thicy_1129	ENOG4108YZY	peptidylprolyl cis-trans isomerase
Thicy_1134	ENOG4105BZ1	(ABC) transporter
Thicy_1135	ENOG4105F8V	Hydrolase, tatD family
Thicy_1136	ENOG4107QRG	dna polymerase iii
Thicy_1137	ENOG4108ZMD	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity)
Thicy_1138	ENOG4105HHA	aminodeoxychorismate lyase
Thicy_1139	ENOG4105YAZ	4-amino-4-deoxychorismate lyase
Thicy_1141	ENOG4105C0Q	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity)
Thicy_1142	ENOG4105VNB	Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity)
Thicy_1143	ENOG4105CHR	reductase
Thicy_1144	ENOG4105CJF	Malonyl coA-acyl carrier protein transacylase
Thicy_1145	ENOG4105CCZ	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity)
Thicy_1146	ENOG4105C6B	Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA (By similarity)
Thicy_1147	ENOG4105VGS	50s ribosomal protein l32
Thicy_1148	ENOG4105FCQ	metal-binding, possibly nucleic acid-binding protein
Thicy_1149	ENOG4108UHJ	MAF-like protein
Thicy_1150	ENOG4107XGZ	Hydrolase
Thicy_1151	ENOG4105EI2	Pseudouridine synthase
Thicy_1152	ENOG4105C03	ribonuclease
Thicy_1156	ENOG4105EAK	ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family
Thicy_1157	ENOG4105EAK	ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family
Thicy_1158	ENOG4107RAQ	aminopeptidase
Thicy_1163	ENOG4105MK2	5-formyltetrahydrofolate cyclo-ligase
Thicy_1167	ENOG4105D7Q	type ii secretion system
Thicy_1168	ENOG4107QHF	type ii secretion system protein e
Thicy_1170	ENOG4105D4P	Coproporphyrinogen iii oxidase
Thicy_1171	ENOG4105C4H	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity)
Thicy_1172	ENOG4105CVE	Lytic murein transglycosylase
Thicy_1173	ENOG4105C1P	efflux transporter, rnd family, mfp subunit
Thicy_1175	ENOG4105M02	This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity)
Thicy_1176	ENOG4105C07	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity)
Thicy_1177	ENOG4105DTN	riboflavin biosynthesis protein ribF
Thicy_1178	ENOG4105CJR	Integral membrane protein (MviN
Thicy_1181	ENOG4105C7D	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
Thicy_1182	ENOG4108S7T	Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP) (By similarity)
Thicy_1183	ENOG4105D5S	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity)
Thicy_1185	ENOG4108ZI0	d,d-heptose 1,7-bisphosphate phosphatase
Thicy_1186	ENOG4105C38	Glycyl-tRNA synthetase beta subunit
Thicy_1187	ENOG4108HMW	glycyl-tRNA synthetase, alpha subunit
Thicy_1189	ENOG4105DR5	peptidase
Thicy_1190	ENOG4105ED7	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling (By similarity)
Thicy_1192	ENOG4105F4R	Transcriptional regulator mode
Thicy_1193	ENOG4105BZH	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity)
Thicy_1194	ENOG4105E05	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity)
Thicy_1195	ENOG4105EMN	RNA polymerase sigma factor
Thicy_1200	ENOG4107QX8	SPFH domain, Band 7 family protein
Thicy_1203	ENOG4108JPZ	Monovalent cation H antiporter subunit D
Thicy_1209	ENOG4105C7R	Atpase associated with various cellular activities aaa_3
Thicy_1214	ENOG4105C1J	atp-dependent rna helicase
Thicy_1220	ENOG4107TPS	domain protein
Thicy_1224	ENOG4108JPZ	Monovalent cation H antiporter subunit D
Thicy_1225	ENOG4108JPZ	Monovalent cation H antiporter subunit D
Thicy_1226	ENOG4105M5H	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
Thicy_1231	ENOG4105D6S	protein involved in catabolism of external DNA
Thicy_1232	ENOG4105CJ3	phosphate transporter
Thicy_1233	ENOG4108KPW	sugar kinase
Thicy_1234	ENOG4105C2N	RNA methyltransferase TrmH family group 3
Thicy_1235	ENOG4105C40	3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity)
Thicy_1236	ENOG4107QN2	dihydrolipoyl dehydrogenase
Thicy_1237	ENOG4105CHQ	Murein-degrading enzyme that degrades murein glycan strands and insoluble, high-molecular weight murein sacculi, with the concomitant formation of a 1,6-anhydromuramoyl product. Lytic transglycosylases (LTs) play an integral role in the metabolism of the peptidoglycan (PG) sacculus. Their lytic action creates space within the PG sacculus to allow for its expansion as well as for the insertion of various structures such as secretion systems and flagella (By similarity)
Thicy_1238	ENOG4105CZI	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
Thicy_1239	ENOG4105F0N	pyrophosphate phospho-hydrolase
Thicy_1240	ENOG4105CCA	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle (By similarity)
Thicy_1241	ENOG4108Z2X	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine (By similarity)
Thicy_1242	ENOG4107R03	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity)
Thicy_1243	ENOG4105CCG	Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity)
Thicy_1244	ENOG4105K8U	2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
Thicy_1245	ENOG4105DJ0	Poly(A) Polymerase
Thicy_1246	ENOG4105P9C	Participates in cysteine desulfuration mediated by SufS. Cysteine desulfuration mobilizes sulfur from L-cysteine to yield L-alanine and constitutes an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules. Functions as a sulfur acceptor for SufS, by mediating the direct transfer of the sulfur atom from the S-sulfanylcysteine of SufS, an intermediate product of cysteine desulfuration process (By similarity)
Thicy_1247	ENOG4105D0M	Protease HtpX homolog
Thicy_1248	ENOG4105CHT	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity)
Thicy_1249	ENOG4105C3P	Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity)
Thicy_1250	ENOG41080G2	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity)
Thicy_1251	ENOG4105DFF	Rod shape-determining protein mreb
Thicy_1254	ENOG4105CJN	penicillin-binding protein
Thicy_1255	ENOG4105CNI	cell division protein FtsW
Thicy_1256	ENOG4105DZ1	carboxypeptidase
Thicy_1257	ENOG4105F0I	Aminotransferase
Thicy_1258	ENOG4108Z43	UPF0250 protein
Thicy_1259	ENOG4108BDP	Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity)
Thicy_1260	ENOG4105C0G	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity)
Thicy_1261	ENOG4105F4C	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress (By similarity)
Thicy_1262	ENOG4105D1Q	UPF0246 protein
Thicy_1264	ENOG4108S0S	Nucleotidyl transferase
Thicy_1265	ENOG4105EHM	Aminoglycoside phosphotransferase
Thicy_1266	ENOG4105E7H	involved in the assembly of LPS in the outer leaflet of the outer membrane. Determines N-hexane tolerance and is involved in outer membrane permeability. Essential for envelope biogenesis (By similarity)
Thicy_1267	ENOG4105DBD	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation (By similarity)
Thicy_1267	ENOG4105DBD	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation (By similarity)
Thicy_1268	ENOG4105CEZ	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) (By similarity)
Thicy_1269	ENOG4105D1X	Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity)
Thicy_1270	ENOG4105DDT	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity)
Thicy_1272	ENOG4105M85	Bola protein
Thicy_1273	ENOG410811Q	Ferredoxin
Thicy_1277	ENOG4105C5F	glutamine synthetase
Thicy_1278	ENOG4105CE8	Transfers the fatty acyl group on membrane lipoproteins (By similarity)
Thicy_1279	ENOG4108JU5	Magnesium and cobalt efflux protein
Thicy_1280	ENOG4105KGE	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity)
Thicy_1281	ENOG4105C9A	Phoh family
Thicy_1282	ENOG4105CIW	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity)
Thicy_1283	ENOG4108HRN	Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity)
Thicy_1284	ENOG4105CUY	Mechanosensitive ion channel
Thicy_1286	ENOG4108YXY	alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
Thicy_1290	ENOG4105CVP	deoxyribo-dipyrimidine photolyase
Thicy_1296	ENOG4108UV6	Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity)
Thicy_1297	ENOG4105DWF	phosphomethylpyrimidine kinase
Thicy_1298	ENOG4108JQ1	Dehydrogenase
Thicy_1299	ENOG4105CQB	FAD linked oxidase domain protein
Thicy_1301	ENOG4107RBR	Receptor
Thicy_1306	ENOG4105CM2	brancheD-chain amino acid aminotransferase
Thicy_1307	ENOG4105C8Y	Acetylornithine aminotransferase
Thicy_1308	ENOG4105DBV	ornithine carbamoyltransferase
Thicy_1309	ENOG4105F3K	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity)
Thicy_1311	ENOG4107QMP	dna polymerase iii subunits gamma and tau
Thicy_1313	ENOG4105CXW	Synthesizes alpha-1,4-glucan chains using ADP-glucose (By similarity)
Thicy_1314	ENOG4105C9C	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity)
Thicy_1315	ENOG4107SBB	4-alpha-glucanotransferase (EC 2.4.1.25)
Thicy_1317	ENOG4107QQ4	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity)
Thicy_1318	ENOG4105CHC	glucokinase (EC 2.7.1.2)
Thicy_1319	ENOG4105F55	Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate (By similarity)
Thicy_1320	ENOG4105DW0	Catalyzes the ADP transfer to D-glycero-D-manno-heptose 1-phosphate, yielding ADP-D,D-heptose (By similarity)
Thicy_1322	ENOG4105C2X	Arabinose 5-phosphate isomerase
Thicy_1323	ENOG4105D8A	3-Deoxy-D-manno-octulosonic-acid transferase
Thicy_1327	ENOG4105DAA	L-lactate
Thicy_1328	ENOG4108UM6	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity)
Thicy_1329	ENOG4105CY8	phosphoribosylaminoimidazole carboxylase atpase subunit
Thicy_1332	ENOG4105CPH	Catalyzes the formation of S-adenosylmethionine from methionine and ATP
Thicy_1333	ENOG4105SYT	Methylenetetrahydrofolate reductase
Thicy_1334	ENOG4105QF0	Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity)
Thicy_1336	ENOG4105F44	Two component transcriptional regulator, winged helix family
Thicy_1337	ENOG4105BZU	Histidine kinase
Thicy_1339	ENOG4107S2Z	UPF0761 membrane protein
Thicy_1340	ENOG4105CN1	protease
Thicy_1341	ENOG41080HT	Transcriptional regulator, arsr family
Thicy_1342	ENOG4105DVQ	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity)
Thicy_1343	ENOG4105CNI	cell division protein FtsW
Thicy_1344	ENOG4105DMZ	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity)
Thicy_1345	ENOG4105CPY	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity)
Thicy_1346	ENOG4108EQQ	Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein (By similarity)
Thicy_1347	ENOG4107EEN	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity)
Thicy_1348	ENOG4105CJN	penicillin-binding protein
Thicy_1350	ENOG4105CDK	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity)
Thicy_1351	ENOG4105CGJ	Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity)
Thicy_1352	ENOG4108V6E	Cell division protein mraZ
Thicy_1353	ENOG4105CU0	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity)
Thicy_1355	ENOG41082RQ	UPF0102 protein
Thicy_1357	ENOG4105DG1	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity)
Thicy_1358	ENOG4105C9G	DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity)
Thicy_1359	ENOG4105KTH	gatB Yqey
Thicy_1360	ENOG4105VCC	30S ribosomal protein S21
Thicy_1361	ENOG4105CPM	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity)
Thicy_1362	ENOG4105K7Z	Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity)
Thicy_1363	ENOG4107ZVW	dihydroneopterin aldolase
Thicy_1365	ENOG4105DWR	Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity)
Thicy_1367	ENOG4105CJW	magnesium transporter
Thicy_1370	ENOG4108F3G	Type I restriction-modification system, R subunit
Thicy_1374	ENOG4105CVR	type I restriction-modification system
Thicy_1375	ENOG4105C3G	gtp-binding protein
Thicy_1376	ENOG4108ZPD	The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity)
Thicy_1377	ENOG4105KW6	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity)
Thicy_1379	ENOG4105KQV	Binds directly to 16S ribosomal RNA (By similarity)
Thicy_1380	ENOG4108UXA	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity)
Thicy_1381	ENOG4105KEM	Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation (By similarity)
Thicy_1382	ENOG4108Z1W	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity)
Thicy_1383	ENOG4105C2S	Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity)
Thicy_1389	ENOG4105C8T	Leucyl-tRNA synthetase
Thicy_1392	ENOG4105CE6	Adenylation and deadenylation of glutamate--ammonia ligase (By similarity)
Thicy_1393	ENOG4108YZA	Nitrogen regulatory protein pii
Thicy_1397	ENOG4105CA4	amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity)
Thicy_1400	ENOG4105C13	Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity)
Thicy_1404	ENOG4105DHZ	alpha beta
Thicy_1405	ENOG4105CJ0	Catalyzes the oxidation of erythronate-4-phosphate to 3- hydroxy-2-oxo-4-phosphonooxybutanoate (By similarity)
Thicy_1410	ENOG4106UJV	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP) (By similarity)
Thicy_1411	ENOG4105F99	Hydroxymethylglutaryl-CoA synthase
Thicy_1415	ENOG4105KB2	stringent starvation protein b
Thicy_1416	ENOG4107MKT	Stringent starvation protein a
Thicy_1417	ENOG4105IHM	Involved in O antigen modification. Involved in the translocation of bactoprenol-linked glucose across the cytoplasmic membrane (By similarity)
Thicy_1419	ENOG4105SA9	Catalyzes the transfer of the L-Ara4N moiety of the glycolipid undecaprenyl phosphate-alpha-L-Ara4N to lipid A. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides (By similarity)
Thicy_1422	ENOG4105WJX	transcriptional regulator MERR family
Thicy_1423	ENOG4108ZUF	This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity)
Thicy_1424	ENOG4105C6A	phenylalanyl-tRNA synthetase (beta subunit)
Thicy_1425	ENOG4105CSS	phenylalanyl-tRNA synthetase (alpha subunit)
Thicy_1426	ENOG4108YZX	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity)
Thicy_1427	ENOG41082NX	50s ribosomal protein l35
Thicy_1428	ENOG4108UUX	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity)
Thicy_1429	ENOG4105C22	threonyL-tRNA synthetase
Thicy_1430	ENOG4105E26	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity)
Thicy_1431	ENOG4108K5H	permease YjgP YjgQ family protein
Thicy_1433	ENOG4105BZ6	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity)
Thicy_1435	ENOG4108ZXC	Two component transcriptional regulator, luxr family
Thicy_1436	ENOG4105CCW	damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity)
Thicy_1439	ENOG4105BZT	Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity)
Thicy_1442	ENOG4105CFX	Catalyzes the ferrous insertion into protoporphyrin IX (By similarity)
Thicy_1443	ENOG4105C25	Primosomal protein n'
Thicy_1444	ENOG4105D5K	Hemolysin activator protein
Thicy_1446	ENOG4105EZV	Transcriptional regulator
Thicy_1448	ENOG4105CG6	trap dicarboxylate transporter dctm subunit
Thicy_1450	ENOG4105CXN	decarboxylase
Thicy_1451	ENOG4105EB3	Histidine kinase
Thicy_1452	ENOG4105E3W	Two component transcriptional regulator (Winged helix family
Thicy_1457	ENOG4105C5I	Dehydrogenase
Thicy_1458	ENOG4105CH5	extracellular solute-binding protein, family 7
Thicy_1462	ENOG4105UGU	tonB-dependent Receptor
Thicy_1463	ENOG4105D65	subunit l
Thicy_1464	ENOG4108ZE9	Monovalent cation H antiporter subunit C
Thicy_1465	ENOG4107R4Z	monovalent cation h antiporter subunit d
Thicy_1467	ENOG4105W4C	monovalent cation H antiporter subunit F
Thicy_1468	ENOG4105KJM	monovalent cation h antiporter subunit g
Thicy_1470	ENOG4105K8F	Phosphoribosyl-amp cyclohydrolase
Thicy_1472	ENOG4105EWT	decarboxylase family
Thicy_1473	ENOG4105C1J	atp-dependent rna helicase
Thicy_1477	ENOG4105XJC	Two component transcriptional regulator (Winged helix family
Thicy_1478	ENOG41062D9	Histidine kinase
Thicy_1479	ENOG4106NZV	Responsible for synthesis of pseudouridine from uracil- 13 in transfer RNAs (By similarity)
Thicy_1481	ENOG4105C0A	alcohol dehydrogenase
Thicy_1482	ENOG4105C4R	Atp-dependent dna helicase
Thicy_1484	ENOG4105FBQ	ATPase associated with various cellular activities aaa_5
Thicy_1489	ENOG4108IQK	o-acetylhomoserine
Thicy_1491	ENOG4107Y49	methyltransferase
Thicy_1499	ENOG410667J	hydrolase
Thicy_1500	ENOG4105PI0	Ferredoxin
Thicy_1508	ENOG4105EAH	synthase
Thicy_1511	ENOG4105C0P	Mg chelatase subunit ChlI
Thicy_1512	ENOG4105W0Z	cytoplasmic protein
Thicy_1514	ENOG4105C75	arginyL-tRNA synthetase
Thicy_1518	ENOG4105C79	DNA protecting protein DprA
Thicy_1519	ENOG4108Z02	Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity)
Thicy_1520	ENOG4105CAE	Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity)
Thicy_1521	ENOG4105CYJ	ribosomal RNA small subunit methyltransferase B
Thicy_1523	ENOG4105ES5	Histidine kinase
Thicy_1524	ENOG4105C1W	two component, sigma54 specific, transcriptional regulator, Fis family
Thicy_1525	ENOG4105C1A	potassium transporter peripheral membrane
Thicy_1526	ENOG4105D37	Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA (By similarity)
Thicy_1535	ENOG4105EUH	cytochrome C oxidase, cbb3-type, subunit i
Thicy_1536	ENOG4105ECC	imidazole-glycerol-phosphate dehydratase
Thicy_1537	ENOG4108UJE	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity)
Thicy_1538	ENOG4105CJV	Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase
Thicy_1539	ENOG4105C0S	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity)
Thicy_1540	ENOG4105KPZ	phosphoribosyl-atp pyrophosphatase
Thicy_1541	ENOG4107YU2	histidine triad (hIT) protein
Thicy_1542	ENOG4105WKS	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity)
Thicy_1543	ENOG4105X8U	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation (By similarity)
Thicy_1547	ENOG4105DEK	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity)
Thicy_1550	ENOG4108V82	Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity)
Thicy_1558	ENOG4105KNY	Microcompartments protein
Thicy_1559	ENOG4108WT6	Carbon dioxide concentrating mechanism protein
Thicy_1565	ENOG4105DT1	RuBisCO catalyzes two reactions the carboxylation of D- ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate
Thicy_1566	ENOG4108YY7	Invasion gene expression up-regulator SirB
Thicy_1568	ENOG4105D3C	The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity)
Thicy_1569	ENOG4105VEQ	Cold shock protein
Thicy_1571	ENOG4107EEK	Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity)
Thicy_1572	ENOG4105CZF	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity)
Thicy_1573	ENOG4105MJ2	Competence protein
Thicy_1574	ENOG4105BZW	Glycerate kinase
Thicy_1575	ENOG4107QW3	Sucrose phosphorylase
Thicy_1576	ENOG4105C3Q	Glycosyl transferase, family 2
Thicy_1578	ENOG4105C4R	Atp-dependent dna helicase
Thicy_1579	ENOG4105K63	Thioredoxin
Thicy_1581	ENOG4105NRA	50s ribosomal protein l31 type b
Thicy_1582	ENOG4105CFZ	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity)
Thicy_1583	ENOG4105KMG	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes (By similarity)
Thicy_1584	ENOG4105CEN	a g-specific adenine glycosylase
Thicy_1585	ENOG4105CZ1	Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity)
Thicy_1586	ENOG4105C2M	dna polymerase I
Thicy_1589	ENOG4105CB3	Required for the thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32) (By similarity)
Thicy_1590	ENOG4107R9T	Catalyzes the formation of 5-methyl-uridine at position 54 (m5U54) in all tRNAs (By similarity)
Thicy_1593	ENOG4105YAJ	CopG Arc MetJ
Thicy_1595	ENOG4105CBF	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity)
Thicy_1598	ENOG4105CA8	Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity)
Thicy_1599	ENOG4107SKI	cobyrinic Acid a,c-diamide synthase
Thicy_1601	ENOG4108V1J	Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity)
Thicy_1602	ENOG4108YYC	ycei family
Thicy_1603	ENOG4105C4G	Synthesis of 3-octaprenyl-4-hydroxybenzoate (By similarity)
Thicy_1605	ENOG4105CAJ	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity)
Thicy_1606	ENOG4105KNM	Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity)
Thicy_1607	ENOG4105C4J	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity)
Thicy_1608	ENOG4105J80	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity)
Thicy_1609	ENOG4105CDG	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity)
Thicy_1610	ENOG4107S15	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity)
Thicy_1611	ENOG4107Z6K	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity)
Thicy_1612	ENOG41081A3	ATP synthase f0, c subunit
Thicy_1613	ENOG4105EE4	it plays a direct role in the translocation of protons across the membrane (By similarity)
Thicy_1617	ENOG4107QJE	Chromosome Partitioning Protein
Thicy_1618	ENOG4105D28	Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity)
Thicy_1619	ENOG4107RE5	NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity)
Thicy_1621	ENOG4105CQ7	ATP-dependent helicase
Thicy_1623	ENOG4105EW6	flavin reductase domain protein, FMN-binding
Thicy_1624	ENOG4107R1K	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) (By similarity)
Thicy_1625	ENOG4105GAV	receptor
Thicy_1630	ENOG41076E6	Uroporphyrinogen-III Synthase
Thicy_1631	ENOG4105D6W	Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity)
Thicy_1633	ENOG4105CH7	arginosuccinase
Thicy_1635	ENOG4105CEY	Amp-dependent synthetase and ligase
Thicy_1636	ENOG4108J8Q	Catalyzes the facilitated diffusion of 2-acyl-glycero-3- phosphoethanolamine (2-acyl-GPE) into the cell (By similarity)
Thicy_1637	ENOG4105BZU	Histidine kinase
Thicy_1639	ENOG4108RRZ	Transcription elongation factor GreB
Thicy_1640	ENOG4105DGW	oligopeptidase A
Thicy_1641	ENOG4109003	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity)
Thicy_1642	ENOG4105HF0	Membrane
Thicy_1643	ENOG4105DHW	Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins
Thicy_1644	ENOG4105NVJ	RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity)
Thicy_1645	ENOG4105VG0	50S ribosomal protein l34
Thicy_1646	ENOG4105C3X	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity)
Thicy_1647	ENOG4105C7D	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
Thicy_1650	ENOG4105BZU	Histidine kinase
Thicy_1651	ENOG4105VEJ	Heat shock protein
Thicy_1652	ENOG4105DBS	Key enzyme in heme biosynthesis. Catalyzes the oxidative decarboxylation of propionic acid side chains of rings A and B of coproporphyrinogen III (By similarity)
Thicy_1653	ENOG4105ERG	peptidase m48, ste24p
Thicy_1654	ENOG4105WHM	Necessary for normal cell division and for the maintenance of normal septation (By similarity)
Thicy_1655	ENOG4105EBH	Required during biogenesis of c-type cytochromes (cytochrome c6 and cytochrome f) at the step of heme attachment (By similarity)
Thicy_1656	ENOG4105CRE	cytochrome C
Thicy_1658	ENOG4105C7K	acetolactate synthase
Thicy_1659	ENOG4107Y03	Nitroreductase
Thicy_1660	ENOG4105C5Q	Transcriptional regulator
Thicy_1662	ENOG4105C1H	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity)
Thicy_1663	ENOG4105C94	Transporter
Thicy_1664	ENOG4105EK0	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity)
Thicy_1665	ENOG4107Z6A	sulfate abc transporter permease
Thicy_1666	ENOG4107QKW	extracellular solute-binding protein family 1
Thicy_1667	ENOG4105C53	Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity)
Thicy_1673	ENOG4105C7R	Atpase associated with various cellular activities aaa_3
Thicy_1674	ENOG4105PFA	Catalyzes the conversion of 5-hydroxyuridine (ho5U) to 5-methoxyuridine (mo5U) at position 34 in tRNA (By similarity)
Thicy_1675	ENOG4105DA6	Catalyzes the conversion of 5-methoxyuridine (mo5U) to uridine-5-oxyacetic acid (cmo5U) at position 34 in tRNA. May also participate in the methylation of uridine-5-oxyacetic acid (cmo5U) to uridine-5-oxyacetic acid methyl ester (mcmo5U) (By similarity)
Thicy_1676	ENOG4105CC0	LysR family Transcriptional regulator
Thicy_1677	ENOG4105C2I	pirin domain protein
Thicy_1678	ENOG4108YYH	Nadph-dependent fmn reductase
Thicy_1679	ENOG4106S48	Murein-degrading enzyme. May play a role in recycling of muropeptides during cell elongation and or cell division
Thicy_1682	ENOG4105CHI	Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB (By similarity)
Thicy_1684	ENOG4106371	Methyltransferase