locus-tag	class	description
Thicy_0001	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
Thicy_0004	COG0446	pyridine nucleotide-disulphide oxidoreductase
Thicy_0005	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
Thicy_0006	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
Thicy_0007	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
Thicy_0008	COG0314	molybdopterin synthase activity
Thicy_0009	COG0303	'Molybdopterin
Thicy_0010	COG0315	cyclic pyranopterin monophosphate synthase activity
Thicy_0012	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
Thicy_0013	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
Thicy_0014	COG1854	S-ribosylhomocysteine lyase activity
Thicy_0016	COG1322	Protein conserved in bacteria
Thicy_0018	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
Thicy_0020	COG0563	adenylate kinase activity
Thicy_0023	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
Thicy_0024	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
Thicy_0025	COG0635	Involved in the biosynthesis of porphyrin-containing compound
Thicy_0027	COG0513	Belongs to the DEAD box helicase family
Thicy_0035	COG2391	methyltransferase activity
Thicy_0036	COG0659	secondary active sulfate transmembrane transporter activity
Thicy_0037	COG0646	methionine synthase
Thicy_0037	COG1410	methionine synthase
Thicy_0042	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
Thicy_0044	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
Thicy_0045	COG1758	RNA polymerase activity
Thicy_0046	COG0668	transmembrane transport
Thicy_0047	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
Thicy_0048	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
Thicy_0050	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
Thicy_0052	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
Thicy_0055	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
Thicy_0055	COG0543	2 iron, 2 sulfur cluster binding
Thicy_0056	COG0708	Exodeoxyribonuclease III
Thicy_0057	COG0788	formyltetrahydrofolate deformylase activity
Thicy_0058	COG1444	tRNA N-acetyltransferase activity
Thicy_0059	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
Thicy_0059	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
Thicy_0064	COG0446	pyridine nucleotide-disulphide oxidoreductase
Thicy_0066	COG1546	Belongs to the CinA family
Thicy_0066	COG1058	Belongs to the CinA family
Thicy_0067	COG2081	HI0933 family
Thicy_0070	COG0678	peroxiredoxin activity
Thicy_0070	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
Thicy_0072	COG1519	Transferase
Thicy_0073	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
Thicy_0074	COG1454	alcohol dehydrogenase
Thicy_0075	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
Thicy_0076	COG0194	GDP metabolic process
Thicy_0077	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
Thicy_0078	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
Thicy_0079	COG0676	glucose-6-phosphate 1-epimerase activity
Thicy_0082	COG3100	YcgL domain-containing protein
Thicy_0083	COG0702	epimerase
Thicy_0084	COG0617	tRNA 3'-terminal CCA addition
Thicy_0088	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
Thicy_0089	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
Thicy_0090	COG0126	phosphoglycerate kinase activity
Thicy_0091	COG0469	pyruvate kinase activity
Thicy_0096	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
Thicy_0098	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
Thicy_0099	COG0546	phosphoglycolate phosphatase activity
Thicy_0100	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
Thicy_0101	COG0512	Glutamine amidotransferase of anthranilate synthase
Thicy_0102	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
Thicy_0103	COG0134	indole-3-glycerol-phosphate synthase activity
Thicy_0104	COG1765	OsmC-like protein
Thicy_0105	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
Thicy_0106	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
Thicy_0107	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
Thicy_0107	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
Thicy_0108	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
Thicy_0109	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
Thicy_0111	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
Thicy_0112	COG0081	regulation of translation
Thicy_0113	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
Thicy_0115	COG0085	RNA polymerase activity
Thicy_0116	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
Thicy_0117	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
Thicy_0118	COG0049	tRNA binding
Thicy_0119	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
Thicy_0120	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
Thicy_0121	COG0051	transcription antitermination factor activity, RNA binding
Thicy_0122	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
Thicy_0123	COG0088	Forms part of the polypeptide exit tunnel
Thicy_0124	COG0089	rRNA binding
Thicy_0125	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
Thicy_0126	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
Thicy_0127	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
Thicy_0128	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
Thicy_0129	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
Thicy_0130	COG0255	Belongs to the universal ribosomal protein uL29 family
Thicy_0131	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
Thicy_0132	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
Thicy_0133	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
Thicy_0134	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
Thicy_0135	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
Thicy_0136	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
Thicy_0137	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
Thicy_0138	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
Thicy_0139	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
Thicy_0140	COG1841	ribosomal large subunit assembly
Thicy_0141	COG0200	Binds to the 23S rRNA
Thicy_0142	COG0201	protein transport
Thicy_0143	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
Thicy_0144	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
Thicy_0145	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
Thicy_0146	COG0202	RNA polymerase activity
Thicy_0147	COG0203	ribosomal protein L17
Thicy_0148	COG0084	hydrolase, TatD family'
Thicy_0149	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
Thicy_0151	COG0019	diaminopimelate decarboxylase activity
Thicy_0153	COG0400	carboxylic ester hydrolase activity
Thicy_0155	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
Thicy_0160	COG0415	Belongs to the DNA photolyase family
Thicy_0162	COG3046	protein related to deoxyribodipyrimidine photolyase
Thicy_0163	COG2814	Major facilitator Superfamily
Thicy_0165	COG0142	geranyltranstransferase activity
Thicy_0166	COG0261	This protein binds to 23S rRNA in the presence of protein L20
Thicy_0167	COG0211	Belongs to the bacterial ribosomal protein bL27 family
Thicy_0168	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
Thicy_0169	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
Thicy_0170	COG0477	Major facilitator Superfamily
Thicy_0172	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
Thicy_0174	COG0459	protein refolding
Thicy_0175	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
Thicy_0176	COG0316	Belongs to the HesB IscA family
Thicy_0178	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
Thicy_0179	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
Thicy_0180	COG1366	Belongs to the anti-sigma-factor antagonist family
Thicy_0182	COG0415	Belongs to the DNA photolyase family
Thicy_0185	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
Thicy_0188	COG0300	oxidoreductase activity
Thicy_0191	COG1108	ABC-type Mn2 Zn2 transport systems permease components
Thicy_0192	COG1121	(ABC) transporter
Thicy_0195	COG0719	Fe-S assembly protein
Thicy_0196	COG0396	ATPase activity
Thicy_0197	COG0719	Fe-S assembly protein
Thicy_0199	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
Thicy_0200	COG1181	Belongs to the D-alanine--D-alanine ligase family
Thicy_0203	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
Thicy_0205	COG0653	protein targeting
Thicy_0206	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
Thicy_0207	COG0352	thiamine-phosphate diphosphorylase activity
Thicy_0208	COG0237	dephospho-CoA kinase activity
Thicy_0210	COG0367	asparagine synthase
Thicy_0211	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
Thicy_0213	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
Thicy_0213	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
Thicy_0214	COG0129	dihydroxy-acid dehydratase activity
Thicy_0216	COG3258	Cytochrome c
Thicy_0220	COG4783	chaperone-mediated protein folding
Thicy_0222	COG1210	Utp--glucose-1-phosphate uridylyltransferase
Thicy_0223	COG0166	Belongs to the GPI family
Thicy_0225	COG1183	phosphatidylcholine synthase activity
Thicy_0226	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
Thicy_0228	COG0456	acetyltransferase
Thicy_0232	COG1959	2 iron, 2 sulfur cluster binding
Thicy_0233	COG0316	Belongs to the HesB IscA family
Thicy_0234	COG0105	UTP biosynthetic process
Thicy_0235	COG0820	rRNA (adenine-C2-)-methyltransferase activity
Thicy_0237	COG0124	histidyl-tRNA synthetase
Thicy_0239	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
Thicy_0240	COG1160	GTP binding
Thicy_0241	COG0277	FAD linked oxidase domain protein
Thicy_0245	COG1162	GTPase activity
Thicy_0246	COG2154	pterin-4-alpha-carbinolamine dehydratase
Thicy_0247	COG0501	Belongs to the peptidase M48B family
Thicy_0248	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
Thicy_0249	COG0028	Belongs to the TPP enzyme family
Thicy_0251	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
Thicy_0252	COG0493	'glutamate synthase
Thicy_0253	COG0067	glutamate synthase
Thicy_0253	COG0069	glutamate synthase activity
Thicy_0253	COG0070	glutamate synthase
Thicy_0254	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
Thicy_0255	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
Thicy_0256	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
Thicy_0258	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
Thicy_0259	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
Thicy_0260	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
Thicy_0261	COG0167	dihydroorotate dehydrogenase activity
Thicy_0262	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
Thicy_0263	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
Thicy_0263	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
Thicy_0264	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
Thicy_0265	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
Thicy_0268	COG0552	protein localization to endoplasmic reticulum
Thicy_0269	COG0612	Peptidase, M16
Thicy_0270	COG0612	Peptidase, M16
Thicy_0271	COG0742	ribosomal rna small subunit methyltransferase
Thicy_0272	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
Thicy_0274	COG1666	GTP binding
Thicy_0275	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
Thicy_0277	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
Thicy_0279	COG0248	Ppx GppA phosphatase
Thicy_0281	COG0628	permease
Thicy_0284	COG0756	dUTP diphosphatase activity
Thicy_0286	COG0811	peptide transport
Thicy_0291	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
Thicy_0292	COG1090	epimerase
Thicy_0295	COG0509	glycine decarboxylation via glycine cleavage system
Thicy_0297	COG1012	belongs to the aldehyde dehydrogenase family
Thicy_0298	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
Thicy_0308	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
Thicy_0314	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
Thicy_0315	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
Thicy_0319	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
Thicy_0320	COG0540	Belongs to the ATCase OTCase family
Thicy_0321	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
Thicy_0322	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
Thicy_0323	COG1678	Uncharacterized ACR, COG1678
Thicy_0325	COG0189	ligase activity
Thicy_0326	COG2308	Evidence 4 Homologs of previously reported genes of
Thicy_0329	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
Thicy_0329	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
Thicy_0331	COG0227	Belongs to the bacterial ribosomal protein bL28 family
Thicy_0332	COG2003	Belongs to the UPF0758 family
Thicy_0333	COG2813	Specifically methylates the guanine in position
Thicy_0333	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
Thicy_0334	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
Thicy_0335	COG0762	integral membrane protein
Thicy_0337	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
Thicy_0338	COG1469	GTP cyclohydrolase I activity
Thicy_0339	COG0523	cobalamin synthesis protein
Thicy_0340	COG0579	oxidoreductase
Thicy_0342	COG0667	Aldo Keto reductase
Thicy_0344	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
Thicy_0353	COG0653	protein targeting
Thicy_0355	COG0308	aminopeptidase N
Thicy_0358	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
Thicy_0360	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
Thicy_0362	COG4771	TonB-dependent receptor
Thicy_0363	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
Thicy_0365	COG2226	methyltransferase
Thicy_0367	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
Thicy_0369	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
Thicy_0370	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
Thicy_0373	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
Thicy_0374	COG0500	methyltransferase
Thicy_0376	COG0542	response to heat
Thicy_0377	COG2982	Protein involved in outer membrane biogenesis
Thicy_0384	COG0583	DNA-binding transcription factor activity
Thicy_0387	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
Thicy_0388	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
Thicy_0389	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
Thicy_0391	COG0138	bifunctional purine biosynthesis protein purh
Thicy_0392	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
Thicy_0394	COG2264	protein methyltransferase activity
Thicy_0395	COG0439	Biotin carboxylase
Thicy_0397	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
Thicy_0398	COG4232	protein-disulfide reductase activity
Thicy_0399	COG3030	protein affecting phage T7 exclusion by the F plasmid
Thicy_0401	COG0500	methyltransferase
Thicy_0404	COG1187	pseudouridine synthase activity
Thicy_0417	COG0725	ABC transporter, periplasmic molybdate-binding protein
Thicy_0419	COG1396	sequence-specific DNA binding
Thicy_0420	COG3550	peptidyl-serine autophosphorylation
Thicy_0421	COG0798	PFAM Bile acid sodium symporter
Thicy_0423	COG3852	Histidine kinase
Thicy_0428	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
Thicy_0429	COG1011	Hydrolase
Thicy_0430	COG0494	nUDIX hydrolase
Thicy_0431	COG1218	3'(2'),5'-bisphosphate nucleotidase
Thicy_0432	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
Thicy_0433	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
Thicy_0434	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
Thicy_0435	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
Thicy_0437	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
Thicy_0438	COG0521	Mo-molybdopterin cofactor biosynthetic process
Thicy_0439	COG2890	protein-(glutamine-N5) methyltransferase activity
Thicy_0440	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
Thicy_0441	COG2814	Major facilitator Superfamily
Thicy_0443	COG3123	guanosine phosphorylase activity
Thicy_0446	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
Thicy_0447	COG0848	biopolymer transport protein
Thicy_0448	COG0811	peptide transport
Thicy_0450	COG0560	Phosphoserine phosphatase
Thicy_0455	COG0519	Catalyzes the synthesis of GMP from XMP
Thicy_0455	COG0518	GMP synthase (glutamine-hydrolyzing) activity
Thicy_0457	COG0590	tRNA wobble adenosine to inosine editing
Thicy_0458	COG0326	Molecular chaperone. Has ATPase activity
Thicy_0460	COG0564	pseudouridine synthase activity
Thicy_0461	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
Thicy_0463	COG1137	ATPase activity
Thicy_0466	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
Thicy_0469	COG1127	ABC transporter
Thicy_0470	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
Thicy_0471	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
Thicy_0474	COG1131	(ABC) transporter
Thicy_0475	COG0842	Transport permease protein
Thicy_0477	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
Thicy_0478	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
Thicy_0479	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
Thicy_0480	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
Thicy_0481	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
Thicy_0482	COG0723	plastoquinol--plastocyanin reductase activity
Thicy_0483	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
Thicy_0484	COG2857	Cytochrome c1
Thicy_0486	COG0483	inositol monophosphate 1-phosphatase activity
Thicy_0487	COG4536	flavin adenine dinucleotide binding
Thicy_0489	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
Thicy_0490	COG0228	four-way junction DNA binding
Thicy_0491	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
Thicy_0492	COG0336	Belongs to the RNA methyltransferase TrmD family
Thicy_0493	COG0335	large ribosomal subunit rRNA binding
Thicy_0496	COG0189	ligase activity
Thicy_0500	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
Thicy_0501	COG1546	Belongs to the CinA family
Thicy_0502	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
Thicy_0503	COG2137	regulation of response to DNA damage stimulus
Thicy_0504	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
Thicy_0507	COG0802	atpase or kinase
Thicy_0509	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
Thicy_0510	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
Thicy_0511	COG1923	regulation of RNA biosynthetic process
Thicy_0512	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
Thicy_0513	COG0330	HflC and HflK could
Thicy_0514	COG0330	HflC and HflK could
Thicy_0515	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
Thicy_0516	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
Thicy_0517	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
Thicy_0520	COG0668	transmembrane transport
Thicy_0522	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
Thicy_0523	COG0232	Belongs to the dGTPase family. Type 2 subfamily
Thicy_0524	COG1671	Belongs to the UPF0178 family
Thicy_0525	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
Thicy_0526	COG1074	ATP-dependent DNA helicase activity
Thicy_0527	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
Thicy_0528	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
Thicy_0541	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
Thicy_0545	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
Thicy_0548	COG1714	RDD family
Thicy_0549	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
Thicy_0557	COG1401	restriction endodeoxyribonuclease activity
Thicy_0562	COG1047	Peptidyl-prolyl cis-trans
Thicy_0564	COG1643	Atp-dependent helicase
Thicy_0566	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
Thicy_0571	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
Thicy_0574	COG4628	conserved protein (DUF2132)
Thicy_0575	COG4681	YaeQ
Thicy_0578	COG4206	TonB-dependent receptor
Thicy_0581	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
Thicy_0583	COG4659	FMN binding
Thicy_0584	COG4658	electron transport chain
Thicy_0586	COG2878	Part of a membrane complex involved in electron transport
Thicy_0587	COG4657	Part of a membrane complex involved in electron transport
Thicy_0588	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
Thicy_0588	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
Thicy_0589	COG0489	protein tyrosine kinase activity
Thicy_0590	COG0717	Belongs to the dCTP deaminase family
Thicy_0592	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
Thicy_0593	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
Thicy_0596	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
Thicy_0601	COG0442	prolyl-tRNA aminoacylation
Thicy_0602	COG0424	maF-like protein
Thicy_0603	COG1530	ribonuclease E activity
Thicy_0605	COG2890	protein-(glutamine-N5) methyltransferase activity
Thicy_0606	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
Thicy_0607	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
Thicy_0609	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
Thicy_0610	COG1917	Cupin 2, conserved barrel domain protein
Thicy_0611	COG2205	protein histidine kinase activity
Thicy_0611	COG0784	Response regulator, receiver
Thicy_0613	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
Thicy_0615	COG0602	queuosine metabolic process
Thicy_0616	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
Thicy_0618	COG0473	3-isopropylmalate dehydrogenase activity
Thicy_0619	COG0739	heme binding
Thicy_0621	COG0101	tRNA pseudouridine synthase activity
Thicy_0622	COG0135	phosphoribosylanthranilate isomerase activity
Thicy_0623	COG0133	tryptophan synthase activity
Thicy_0624	COG0159	tryptophan synthase activity
Thicy_0625	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
Thicy_0626	COG0285	dihydrofolate synthase activity
Thicy_0630	COG1534	Rna-binding protein
Thicy_0631	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
Thicy_0632	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
Thicy_0633	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
Thicy_0634	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
Thicy_0635	COG0149	triose-phosphate isomerase activity
Thicy_0637	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
Thicy_0638	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
Thicy_0639	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
Thicy_0640	COG0649	NAD binding
Thicy_0643	COG1034	ATP synthesis coupled electron transport
Thicy_0644	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
Thicy_0645	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
Thicy_0647	COG0713	ATP synthesis coupled electron transport
Thicy_0650	COG1007	ATP synthesis coupled electron transport
Thicy_0652	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
Thicy_0653	COG1047	Peptidyl-prolyl cis-trans
Thicy_0655	COG0488	(ABC) transporter
Thicy_0658	COG0544	peptidyl-prolyl cis-trans isomerase activity
Thicy_0659	COG0740	serine-type endopeptidase activity
Thicy_0660	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
Thicy_0661	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
Thicy_0662	COG2850	peptidyl-arginine hydroxylation
Thicy_0664	COG1049	propionate catabolic process, 2-methylcitrate cycle
Thicy_0668	COG1321	iron dependent repressor
Thicy_0668	COG1108	ABC-type Mn2 Zn2 transport systems permease components
Thicy_0669	COG1121	(ABC) transporter
Thicy_0670	COG0803	Belongs to the bacterial solute-binding protein 9 family
Thicy_0672	COG3852	Histidine kinase
Thicy_0673	COG2204	response regulator
Thicy_0675	COG0688	phosphatidylethanolamine metabolic process
Thicy_0676	COG0137	argininosuccinate synthase activity
Thicy_0677	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
Thicy_0679	COG1301	dicarboxylic acid transport
Thicy_0680	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
Thicy_0681	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
Thicy_0683	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
Thicy_0684	COG0215	cysteine-tRNA ligase activity
Thicy_0685	COG0741	lytic transglycosylase activity
Thicy_0686	COG1388	LysM domain
Thicy_0686	COG0741	lytic transglycosylase activity
Thicy_0689	COG0328	RNA-DNA hybrid ribonuclease activity
Thicy_0691	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
Thicy_0695	COG3023	N-Acetylmuramoyl-L-alanine amidase
Thicy_0696	COG0716	FMN binding
Thicy_0698	COG1051	belongs to the nudix hydrolase family
Thicy_0699	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
Thicy_0700	COG0508	dehydrogenase complex catalyzes the overall conversion of
Thicy_0701	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
Thicy_0702	COG0564	pseudouridine synthase activity
Thicy_0703	COG2983	Belongs to the UPF0260 family
Thicy_0705	COG1944	ATP diphosphatase activity
Thicy_0707	COG0825	malonyl-CoA metabolic process
Thicy_0708	COG0037	tRNA processing
Thicy_0709	COG0504	CTP synthase activity
Thicy_0710	COG2877	3-deoxy-8-phosphooctulonate synthase activity
Thicy_0711	COG0148	phosphopyruvate hydratase activity
Thicy_0712	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
Thicy_0715	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
Thicy_0716	COG1238	metal cluster binding
Thicy_0718	COG0436	Aminotransferase
Thicy_0721	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
Thicy_0722	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
Thicy_0722	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
Thicy_0724	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
Thicy_0725	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
Thicy_0727	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
Thicy_0729	COG1070	Carbohydrate kinase
Thicy_0730	COG1196	nuclear chromosome segregation
Thicy_0732	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
Thicy_0733	COG3028	Belongs to the UPF0307 family
Thicy_0736	COG0252	asparaginase activity
Thicy_0737	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
Thicy_0738	COG2350	Protein conserved in bacteria
Thicy_0739	COG2917	probably involved in intracellular septation
Thicy_0740	COG0613	PHP domain protein
Thicy_0741	COG0009	L-threonylcarbamoyladenylate synthase
Thicy_0742	COG1994	Peptidase M50
Thicy_0743	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
Thicy_0744	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
Thicy_0745	COG1187	pseudouridine synthase activity
Thicy_0753	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
Thicy_0754	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
Thicy_0755	COG0363	glucosamine-6-phosphate deaminase activity
Thicy_0757	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
Thicy_0758	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
Thicy_0760	COG0322	excinuclease ABC activity
Thicy_0764	COG0582	viral genome integration into host DNA
Thicy_0776	COG3012	SEC-C Motif Domain Protein
Thicy_0777	COG3707	response regulator
Thicy_0778	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
Thicy_0779	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
Thicy_0780	COG1116	anion transmembrane transporter activity
Thicy_0781	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
Thicy_0782	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
Thicy_0784	COG0243	molybdopterin cofactor binding
Thicy_0785	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
Thicy_0785	COG1648	precorrin-2 dehydrogenase activity
Thicy_0787	COG0303	'Molybdopterin
Thicy_0788	COG0746	molybdenum cofactor guanylyltransferase activity
Thicy_0789	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
Thicy_0792	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
Thicy_0793	COG1570	exodeoxyribonuclease VII activity
Thicy_0793	COG1570	exodeoxyribonuclease VII activity
Thicy_0798	COG0745	RESPONSE REGULATOR receiver
Thicy_0803	COG0494	nUDIX hydrolase
Thicy_0804	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
Thicy_0805	COG0305	Participates in initiation and elongation during chromosome replication
Thicy_0806	COG0359	binds to the 23S rRNA
Thicy_0808	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
Thicy_0809	COG0360	Binds together with S18 to 16S ribosomal RNA
Thicy_0810	COG0284	orotidine-5'-phosphate decarboxylase activity
Thicy_0812	COG0776	regulation of translation
Thicy_0815	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
Thicy_0816	COG0287	Prephenate dehydrogenase
Thicy_0817	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
Thicy_0819	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
Thicy_0821	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
Thicy_0823	COG1028	Short-chain dehydrogenase reductase Sdr
Thicy_0826	COG2183	response to ionizing radiation
Thicy_0827	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
Thicy_0832	COG0659	secondary active sulfate transmembrane transporter activity
Thicy_0834	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
Thicy_0834	COG0047	phosphoribosylformylglycinamidine synthase activity
Thicy_0836	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
Thicy_0837	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
Thicy_0838	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
Thicy_0841	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
Thicy_0845	COG3530	Putative quorum-sensing-regulated virulence factor
Thicy_0854	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
Thicy_0855	COG0601	transmembrane transport
Thicy_0859	COG1185	polyribonucleotide nucleotidyltransferase activity
Thicy_0860	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
Thicy_0862	COG0500	methyltransferase
Thicy_0863	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
Thicy_0864	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
Thicy_0865	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
Thicy_0866	COG0195	Participates in both transcription termination and antitermination
Thicy_0866	COG2251	uridine kinase activity
Thicy_0867	COG0779	Required for maturation of 30S ribosomal subunits
Thicy_0870	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
Thicy_0872	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
Thicy_0873	COG0587	DNA-directed DNA polymerase activity
Thicy_0874	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
Thicy_0877	COG1053	succinate dehydrogenase
Thicy_0878	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
Thicy_0880	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
Thicy_0881	COG0736	holo-[acyl-carrier-protein] synthase activity
Thicy_0882	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
Thicy_0883	COG1381	Involved in DNA repair and RecF pathway recombination
Thicy_0884	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
Thicy_0885	COG0571	ribonuclease III activity
Thicy_0887	COG0481	GTPase activity
Thicy_0888	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
Thicy_0895	COG2161	toxin-antitoxin pair type II binding
Thicy_0901	COG2827	Endonuclease containing a URI domain
Thicy_0902	COG5611	PilT protein domain protein
Thicy_0906	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
Thicy_0907	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
Thicy_0908	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
Thicy_0909	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
Thicy_0924	COG0584	glycerophosphoryl diester phosphodiesterase
Thicy_0925	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
Thicy_0925	COG0463	Glycosyl transferase, family 2
Thicy_0927	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
Thicy_0939	COG0859	PFAM glycosyl transferase family 9
Thicy_0943	COG0859	PFAM glycosyl transferase family 9
Thicy_0946	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
Thicy_0949	COG1132	(ABC) transporter
Thicy_0954	COG0589	response to stress
Thicy_0955	COG1214	PFAM Peptidase M22, glycoprotease
Thicy_0956	COG1199	ATP-dependent helicase activity
Thicy_0957	COG0257	Belongs to the bacterial ribosomal protein bL36 family
Thicy_0958	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
Thicy_0959	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
Thicy_0960	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
Thicy_0961	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
Thicy_0962	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
Thicy_0963	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
Thicy_0964	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
Thicy_0966	COG0575	Belongs to the CDS family
Thicy_0967	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
Thicy_0968	COG0233	cytoplasmic translational termination
Thicy_0969	COG0528	UMP kinase activity
Thicy_0970	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
Thicy_0971	COG0052	Belongs to the universal ribosomal protein uS2 family
Thicy_0972	COG0024	Methionine aminopeptidase
Thicy_0973	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
Thicy_0978	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
Thicy_0979	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
Thicy_0980	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
Thicy_0981	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
Thicy_0982	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
Thicy_0983	COG0531	amino acid
Thicy_0983	COG1674	ftsk spoiiie
Thicy_0984	COG0492	ferredoxin-NADP+ reductase activity
Thicy_0985	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
Thicy_0986	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
Thicy_0987	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
Thicy_0988	COG1862	Preprotein translocase
Thicy_0989	COG0343	queuine tRNA-ribosyltransferase activity
Thicy_0990	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
Thicy_1004	COG1459	type II secretion system
Thicy_1005	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
Thicy_1007	COG3031	protein transport across the cell outer membrane
Thicy_1008	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
Thicy_1010	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
Thicy_1011	COG0354	folic acid binding
Thicy_1014	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
Thicy_1017	COG0823	Involved in the tonB-independent uptake of proteins
Thicy_1019	COG0848	biopolymer transport protein
Thicy_1021	COG2255	four-way junction helicase activity
Thicy_1022	COG0632	four-way junction helicase activity
Thicy_1023	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
Thicy_1025	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
Thicy_1026	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
Thicy_1028	COG0300	oxidoreductase activity
Thicy_1029	COG0142	geranyltranstransferase activity
Thicy_1030	COG0720	synthase
Thicy_1031	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
Thicy_1033	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
Thicy_1035	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
Thicy_1036	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
Thicy_1037	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
Thicy_1040	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
Thicy_1040	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
Thicy_1041	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
Thicy_1042	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
Thicy_1043	COG0488	(ABC) transporter
Thicy_1044	COG2199	diguanylate cyclase activity
Thicy_1044	COG2203	Gaf domain
Thicy_1046	COG2197	response regulator
Thicy_1048	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
Thicy_1049	COG1940	carbohydrate kinase activity
Thicy_1050	COG2833	Protein of unknown function (DUF455)
Thicy_1052	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
Thicy_1054	COG0505	Belongs to the CarA family
Thicy_1055	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
Thicy_1056	COG0484	heat shock protein binding
Thicy_1057	COG0443	Heat shock 70 kDa protein
Thicy_1058	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
Thicy_1059	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
Thicy_1060	COG0497	DNA recombination
Thicy_1061	COG0735	belongs to the Fur family
Thicy_1062	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
Thicy_1063	COG2914	Belongs to the UPF0125 (RnfH) family
Thicy_1064	COG2867	negative regulation of translational initiation
Thicy_1065	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
Thicy_1067	COG4181	ATPase activity
Thicy_1069	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
Thicy_1071	COG1999	signal sequence binding
Thicy_1076	COG0488	(ABC) transporter
Thicy_1077	COG1136	(ABC) transporter
Thicy_1080	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
Thicy_1082	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
Thicy_1085	COG3150	esterase
Thicy_1087	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
Thicy_1088	COG2835	tetraacyldisaccharide 4'-kinase activity
Thicy_1089	COG1663	tetraacyldisaccharide 4'-kinase activity
Thicy_1091	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
Thicy_1095	COG0658	competence protein
Thicy_1095	COG2333	competence protein COMEC
Thicy_1097	COG1067	ATP-dependent peptidase activity
Thicy_1098	COG2515	1-aminocyclopropane-1-carboxylate deaminase
Thicy_1102	COG0542	response to heat
Thicy_1103	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
Thicy_1105	COG0482	sulfurtransferase activity
Thicy_1106	COG2915	High frequency lysogenization protein hflD homolog
Thicy_1107	COG0625	glutathione transferase activity
Thicy_1108	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
Thicy_1111	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
Thicy_1115	COG1393	Belongs to the ArsC family
Thicy_1116	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
Thicy_1119	COG0733	neurotransmitter:sodium symporter activity
Thicy_1121	COG1472	Belongs to the glycosyl hydrolase 3 family
Thicy_1122	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
Thicy_1123	COG0601	transmembrane transport
Thicy_1126	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
Thicy_1127	COG0045	succinate-CoA ligase (ADP-forming) activity
Thicy_1129	COG1047	Peptidyl-prolyl cis-trans
Thicy_1134	COG1132	(ABC) transporter
Thicy_1135	COG0084	hydrolase, TatD family'
Thicy_1137	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
Thicy_1138	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
Thicy_1139	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
Thicy_1140	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
Thicy_1141	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
Thicy_1142	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
Thicy_1144	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
Thicy_1145	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
Thicy_1146	COG0416	fatty acid biosynthetic process
Thicy_1147	COG0333	Belongs to the bacterial ribosomal protein bL32 family
Thicy_1148	COG1399	metal-binding, possibly nucleic acid-binding protein
Thicy_1149	COG0424	maF-like protein
Thicy_1150	COG0546	phosphoglycolate phosphatase activity
Thicy_1152	COG1530	ribonuclease E activity
Thicy_1155	COG0583	DNA-binding transcription factor activity
Thicy_1156	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
Thicy_1157	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
Thicy_1158	COG0006	proline dipeptidase activity
Thicy_1163	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
Thicy_1168	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
Thicy_1171	COG0116	Belongs to the methyltransferase superfamily
Thicy_1171	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
Thicy_1172	COG2951	lytic endotransglycosylase activity
Thicy_1173	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
Thicy_1175	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
Thicy_1176	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
Thicy_1177	COG0196	riboflavin kinase activity
Thicy_1179	COG0028	Belongs to the TPP enzyme family
Thicy_1181	COG0187	DNA topoisomerase II activity
Thicy_1182	COG0259	pyridoxamine-phosphate oxidase activity
Thicy_1183	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
Thicy_1185	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
Thicy_1186	COG0751	glycine-tRNA ligase activity
Thicy_1187	COG0752	glycyl-tRNA synthetase alpha subunit
Thicy_1189	COG0739	heme binding
Thicy_1190	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
Thicy_1193	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
Thicy_1194	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
Thicy_1195	COG1595	DNA-templated transcription, initiation
Thicy_1200	COG0330	HflC and HflK could
Thicy_1209	COG0714	Associated with various cellular activities
Thicy_1214	COG0513	Belongs to the DEAD box helicase family
Thicy_1220	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
Thicy_1220	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
Thicy_1223	COG2133	pyrroloquinoline quinone binding
Thicy_1224	COG0651	ATP synthesis coupled electron transport
Thicy_1225	COG0651	ATP synthesis coupled electron transport
Thicy_1226	COG0713	ATP synthesis coupled electron transport
Thicy_1231	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
Thicy_1232	COG0306	phosphate transporter
Thicy_1233	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
Thicy_1234	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
Thicy_1235	COG0557	exoribonuclease II activity
Thicy_1237	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
Thicy_1238	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
Thicy_1239	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
Thicy_1240	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
Thicy_1241	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
Thicy_1242	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
Thicy_1243	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
Thicy_1244	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
Thicy_1245	COG0617	tRNA 3'-terminal CCA addition
Thicy_1247	COG0501	Belongs to the peptidase M48B family
Thicy_1248	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
Thicy_1249	COG0154	amidase activity
Thicy_1250	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
Thicy_1251	COG1077	Cell shape determining protein MreB Mrl
Thicy_1253	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
Thicy_1254	COG0768	penicillin binding
Thicy_1255	COG0772	Belongs to the SEDS family
Thicy_1256	COG1686	Belongs to the peptidase S11 family
Thicy_1258	COG2921	Belongs to the UPF0250 family
Thicy_1259	COG0321	lipoyl(octanoyl) transferase activity
Thicy_1260	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
Thicy_1261	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
Thicy_1262	COG3022	response to hydroperoxide
Thicy_1264	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
Thicy_1265	COG3178	'Phosphotransferase
Thicy_1266	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
Thicy_1267	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
Thicy_1267	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
Thicy_1268	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
Thicy_1269	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
Thicy_1270	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
Thicy_1272	COG0271	Belongs to the BolA IbaG family
Thicy_1277	COG0174	glutamine synthetase
Thicy_1278	COG0815	Transfers the fatty acyl group on membrane lipoproteins
Thicy_1279	COG4535	Mg2 and Co2 transporter CorC
Thicy_1281	COG1702	phosphate starvation-inducible protein PhoH
Thicy_1282	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
Thicy_1284	COG0668	transmembrane transport
Thicy_1286	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
Thicy_1290	COG0415	Belongs to the DNA photolyase family
Thicy_1294	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
Thicy_1296	COG0352	thiamine-phosphate diphosphorylase activity
Thicy_1297	COG0351	phosphomethylpyrimidine kinase
Thicy_1298	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
Thicy_1299	COG0277	FAD linked oxidase domain protein
Thicy_1301	COG1629	transport
Thicy_1301	COG4774	siderophore transport
Thicy_1307	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
Thicy_1308	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
Thicy_1309	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
Thicy_1310	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
Thicy_1311	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
Thicy_1312	COG0058	SHG alpha-glucan phosphorylase activity
Thicy_1313	COG0297	glycogen (starch) synthase activity
Thicy_1314	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
Thicy_1317	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
Thicy_1319	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
Thicy_1320	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
Thicy_1320	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
Thicy_1322	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
Thicy_1322	COG0517	IMP dehydrogenase activity
Thicy_1323	COG1519	Transferase
Thicy_1327	COG1620	l-lactate permease
Thicy_1328	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
Thicy_1332	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
Thicy_1333	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
Thicy_1334	COG1385	rRNA (uridine-N3-)-methyltransferase activity
Thicy_1336	COG0745	RESPONSE REGULATOR receiver
Thicy_1337	COG2205	protein histidine kinase activity
Thicy_1339	COG1295	ribonuclease BN
Thicy_1340	COG0793	Belongs to the peptidase S41A family
Thicy_1341	COG0640	Transcriptional regulator
Thicy_1342	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
Thicy_1343	COG0772	Belongs to the SEDS family
Thicy_1344	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
Thicy_1345	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
Thicy_1346	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
Thicy_1347	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
Thicy_1350	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
Thicy_1351	COG0275	rRNA processing
Thicy_1352	COG2001	Belongs to the MraZ family
Thicy_1355	COG0792	nuclease activity
Thicy_1356	COG0783	Belongs to the Dps family
Thicy_1359	COG1610	YqeY-like protein
Thicy_1360	COG0828	Belongs to the bacterial ribosomal protein bS21 family
Thicy_1361	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
Thicy_1362	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
Thicy_1363	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
Thicy_1365	COG1968	undecaprenyl-diphosphatase activity
Thicy_1367	COG2239	Acts as a magnesium transporter
Thicy_1374	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
Thicy_1375	COG0012	GTP binding
Thicy_1376	COG0193	aminoacyl-tRNA hydrolase activity
Thicy_1377	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
Thicy_1379	COG0268	Binds directly to 16S ribosomal RNA
Thicy_1380	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
Thicy_1381	COG0799	negative regulation of ribosome biogenesis
Thicy_1382	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
Thicy_1383	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
Thicy_1389	COG0495	leucyl-tRNA aminoacylation
Thicy_1392	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
Thicy_1394	COG0004	ammonium transporteR
Thicy_1397	COG0525	valine-tRNA ligase activity
Thicy_1400	COG4974	Belongs to the 'phage' integrase family
Thicy_1404	COG2945	thiolester hydrolase activity
Thicy_1405	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
Thicy_1410	COG1304	FMN binding
Thicy_1411	COG3425	synthase
Thicy_1415	COG2969	positive regulation of protein catabolic process
Thicy_1416	COG0625	glutathione transferase activity
Thicy_1417	COG2246	polysaccharide biosynthetic process
Thicy_1418	COG0463	Glycosyl transferase, family 2
Thicy_1419	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
Thicy_1423	COG0776	regulation of translation
Thicy_1424	COG0072	phenylalanine-tRNA ligase activity
Thicy_1424	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
Thicy_1425	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
Thicy_1426	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
Thicy_1427	COG0291	Belongs to the bacterial ribosomal protein bL35 family
Thicy_1428	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
Thicy_1429	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
Thicy_1430	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
Thicy_1431	COG0795	lipopolysaccharide-transporting ATPase activity
Thicy_1433	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
Thicy_1436	COG0556	nucleotide-excision repair
Thicy_1439	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
Thicy_1442	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
Thicy_1443	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
Thicy_1446	COG1917	Cupin 2, conserved barrel domain protein
Thicy_1446	COG2169	Transcriptional regulator
Thicy_1448	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
Thicy_1450	COG1982	Orn Lys Arg decarboxylase major
Thicy_1451	COG2205	protein histidine kinase activity
Thicy_1452	COG0745	RESPONSE REGULATOR receiver
Thicy_1455	COG1309	transcriptional regulator
Thicy_1457	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
Thicy_1458	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
Thicy_1463	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
Thicy_1463	COG2111	Na H antiporter
Thicy_1464	COG1006	Multisubunit Na H antiporter MnhC subunit
Thicy_1465	COG0651	ATP synthesis coupled electron transport
Thicy_1467	COG2212	antiporter activity
Thicy_1468	COG1320	monovalent cation:proton antiporter activity
Thicy_1470	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
Thicy_1472	COG1611	Belongs to the LOG family
Thicy_1473	COG0513	Belongs to the DEAD box helicase family
Thicy_1477	COG0745	RESPONSE REGULATOR receiver
Thicy_1479	COG0585	pseudouridine synthase activity
Thicy_1481	COG1454	alcohol dehydrogenase
Thicy_1482	COG0210	DNA helicase
Thicy_1484	COG1401	restriction endodeoxyribonuclease activity
Thicy_1489	COG2873	o-acetylhomoserine
Thicy_1491	COG2813	Specifically methylates the guanine in position
Thicy_1499	COG0561	phosphatase activity
Thicy_1506	COG1562	ergosterol biosynthetic process
Thicy_1508	COG0142	geranyltranstransferase activity
Thicy_1514	COG0018	arginyl-trna synthetase
Thicy_1518	COG0758	DNA mediated transformation
Thicy_1519	COG0242	peptide deformylase activity
Thicy_1520	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
Thicy_1521	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
Thicy_1523	COG5000	phosphorelay sensor kinase activity
Thicy_1524	COG2204	response regulator
Thicy_1525	COG0569	domain protein
Thicy_1535	COG3278	Belongs to the heme-copper respiratory oxidase family
Thicy_1536	COG0131	Imidazoleglycerol-phosphate dehydratase
Thicy_1537	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
Thicy_1538	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
Thicy_1539	COG0107	imidazoleglycerol-phosphate synthase activity
Thicy_1540	COG0140	phosphoribosyl-ATP diphosphatase activity
Thicy_1541	COG0537	adenosine 5'-monophosphoramidase activity
Thicy_1543	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
Thicy_1547	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
Thicy_1550	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
Thicy_1552	COG0583	DNA-binding transcription factor activity
Thicy_1565	COG1850	ribulose-bisphosphate carboxylase activity
Thicy_1566	COG3094	Invasion gene expression up-regulator, SirB
Thicy_1568	COG0596	Alpha beta hydrolase
Thicy_1569	COG1278	Cold shock
Thicy_1571	COG0156	8-amino-7-oxononanoate synthase activity
Thicy_1572	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
Thicy_1573	COG1040	competence protein
Thicy_1574	COG1929	Belongs to the glycerate kinase type-1 family
Thicy_1575	COG0366	Alpha amylase catalytic
Thicy_1576	COG1215	transferase activity, transferring glycosyl groups
Thicy_1580	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
Thicy_1581	COG0254	rRNA binding
Thicy_1582	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
Thicy_1583	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
Thicy_1584	COG1194	a g-specific adenine glycosylase
Thicy_1585	COG0220	tRNA (guanine-N7-)-methyltransferase activity
Thicy_1589	COG0037	tRNA processing
Thicy_1590	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
Thicy_1593	COG3609	addiction module antidote protein, CC2985 family
Thicy_1595	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
Thicy_1598	COG2022	thiamine diphosphate biosynthetic process
Thicy_1599	COG1192	Involved in chromosome partitioning
Thicy_1601	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
Thicy_1602	COG2353	YceI-like domain
Thicy_1603	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
Thicy_1605	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
Thicy_1606	COG0355	proton-transporting ATP synthase activity, rotational mechanism
Thicy_1607	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
Thicy_1608	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
Thicy_1609	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
Thicy_1610	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
Thicy_1611	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
Thicy_1612	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
Thicy_1613	COG0356	it plays a direct role in the translocation of protons across the membrane
Thicy_1617	COG1192	Involved in chromosome partitioning
Thicy_1618	COG0357	Ribosomal RNA small subunit methyltransferase G
Thicy_1619	COG0445	tRNA wobble uridine modification
Thicy_1621	COG1643	Atp-dependent helicase
Thicy_1623	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
Thicy_1624	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
Thicy_1624	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
Thicy_1625	COG4772	TonB-dependent receptor
Thicy_1631	COG0181	hydroxymethylbilane synthase activity
Thicy_1633	COG0165	Argininosuccinate lyase
Thicy_1636	COG2814	Major facilitator Superfamily
Thicy_1637	COG0784	Response regulator, receiver
Thicy_1637	COG5002	protein histidine kinase activity
Thicy_1639	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
Thicy_1640	COG0339	signal peptide processing
Thicy_1641	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
Thicy_1642	COG0730	response to heat
Thicy_1643	COG0706	membrane insertase activity
Thicy_1644	COG0594	ribonuclease P activity
Thicy_1645	COG0230	Belongs to the bacterial ribosomal protein bL34 family
Thicy_1646	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
Thicy_1647	COG0187	DNA topoisomerase II activity
Thicy_1650	COG4191	Histidine kinase
Thicy_1651	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
Thicy_1652	COG0408	coproporphyrinogen oxidase activity
Thicy_1653	COG4783	chaperone-mediated protein folding
Thicy_1654	COG0218	Necessary for normal cell division and for the maintenance of normal septation
Thicy_1655	COG1333	cytochrome c biogenesis protein
Thicy_1656	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
Thicy_1657	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
Thicy_1659	COG0778	Nitroreductase
Thicy_1662	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
Thicy_1663	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
Thicy_1664	COG0009	L-threonylcarbamoyladenylate synthase
Thicy_1665	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
Thicy_1667	COG3842	ATPase activity
Thicy_1669	COG2304	oxidoreductase activity
Thicy_1673	COG0714	Associated with various cellular activities
Thicy_1674	COG0500	methyltransferase
Thicy_1675	COG2226	methyltransferase
Thicy_1676	COG0583	DNA-binding transcription factor activity
Thicy_1677	COG1741	Belongs to the pirin family
Thicy_1679	COG0741	lytic transglycosylase activity
Thicy_1684	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity