locus-tag	class	description
JX580_00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
JX580_00010	COG0592	DNA-directed DNA polymerase activity
JX580_00015	COG4133	protoheme IX ABC transporter activity
JX580_00035	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
JX580_00040	COG1138	Cytochrome C-type biogenesis protein
JX580_00045	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
JX580_00060	COG3005	denitrification pathway
JX580_00070	COG0446	pyridine nucleotide-disulphide oxidoreductase
JX580_00080	COG0446	pyridine nucleotide-disulphide oxidoreductase
JX580_00085	COG1793	dna ligase
JX580_00090	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
JX580_00095	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
JX580_00100	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
JX580_00105	COG0314	molybdopterin synthase activity
JX580_00110	COG0303	'Molybdopterin
JX580_00115	COG0315	cyclic pyranopterin monophosphate synthase activity
JX580_00145	COG1561	YicC-like family, N-terminal region
JX580_00150	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
JX580_00155	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
JX580_00160	COG0635	Involved in the biosynthesis of porphyrin-containing compound
JX580_00170	COG0513	Belongs to the DEAD box helicase family
JX580_00180	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
JX580_00185	COG0254	rRNA binding
JX580_00190	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
JX580_00200	COG0210	DNA helicase
JX580_00205	COG3161	chorismate lyase activity
JX580_00210	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
JX580_00220	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
JX580_00225	COG1758	RNA polymerase activity
JX580_00230	COG0668	transmembrane transport
JX580_00235	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
JX580_00240	COG1194	a g-specific adenine glycosylase
JX580_00245	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
JX580_00250	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
JX580_00280	COG1217	gtp-binding protein TYPA
JX580_00290	COG2391	methyltransferase activity
JX580_00295	COG0659	secondary active sulfate transmembrane transporter activity
JX580_00315	COG0646	methionine synthase
JX580_00315	COG1410	methionine synthase
JX580_00325	COG1215	transferase activity, transferring glycosyl groups
JX580_00335	COG1929	Belongs to the glycerate kinase type-1 family
JX580_00345	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
JX580_00350	COG0676	glucose-6-phosphate 1-epimerase activity
JX580_00410	COG1216	Glycosyl transferase, family 2
JX580_00420	COG1132	(ABC) transporter
JX580_00485	COG1519	Transferase
JX580_00495	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
JX580_00495	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
JX580_00500	COG0859	PFAM glycosyl transferase family 9
JX580_00505	COG3307	-O-antigen
JX580_00510	COG0463	Glycosyl transferase, family 2
JX580_00540	COG1850	ribulose-bisphosphate carboxylase activity
JX580_00570	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
JX580_00575	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
JX580_00605	COG0583	DNA-binding transcription factor activity
JX580_00615	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
JX580_00620	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
JX580_00635	COG3100	YcgL domain-containing protein
JX580_00640	COG0702	epimerase
JX580_00645	COG0617	tRNA 3'-terminal CCA addition
JX580_00660	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
JX580_00665	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
JX580_00670	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
JX580_00675	COG0126	phosphoglycerate kinase activity
JX580_00690	COG2813	Specifically methylates the guanine in position
JX580_00700	COG0210	DNA helicase
JX580_00730	COG0585	pseudouridine synthase activity
JX580_00735	COG0840	transmembrane signaling receptor activity
JX580_00745	COG0840	transmembrane signaling receptor activity
JX580_00750	COG0840	transmembrane signaling receptor activity
JX580_00755	COG0513	Belongs to the DEAD box helicase family
JX580_00760	COG1611	Belongs to the LOG family
JX580_00780	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
JX580_00790	COG1320	monovalent cation:proton antiporter activity
JX580_00795	COG2212	antiporter activity
JX580_00805	COG0651	ATP synthesis coupled electron transport
JX580_00810	COG1006	Multisubunit Na H antiporter MnhC subunit
JX580_00815	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
JX580_00815	COG2111	Na H antiporter
JX580_00820	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
JX580_00825	COG2824	Alkylphosphonate utilization operon protein PhnA
JX580_00870	COG2801	Transposase and inactivated derivatives
JX580_00895	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
JX580_00905	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
JX580_00910	COG0298	carbon dioxide binding
JX580_00935	COG0375	protein maturation
JX580_00940	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
JX580_00945	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
JX580_00975	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
JX580_00980	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
JX580_01005	COG0745	RESPONSE REGULATOR receiver
JX580_01010	COG2205	protein histidine kinase activity
JX580_01020	COG0697	spore germination
JX580_01030	COG1666	GTP binding
JX580_01040	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
JX580_01055	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
JX580_01070	COG0493	'glutamate synthase
JX580_01075	COG0067	glutamate synthase
JX580_01075	COG0069	glutamate synthase activity
JX580_01075	COG0070	glutamate synthase
JX580_01080	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
JX580_01085	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
JX580_01090	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
JX580_01095	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
JX580_01100	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
JX580_01105	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
JX580_01110	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
JX580_01115	COG0167	dihydroorotate dehydrogenase activity
JX580_01120	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
JX580_01225	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
JX580_01235	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
JX580_01245	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
JX580_01250	COG0316	Belongs to the HesB IscA family
JX580_01260	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
JX580_01265	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
JX580_01270	COG1366	Belongs to the anti-sigma-factor antagonist family
JX580_01280	COG0415	Belongs to the DNA photolyase family
JX580_01295	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
JX580_01305	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
JX580_01310	COG0300	oxidoreductase activity
JX580_01360	COG1518	maintenance of DNA repeat elements
JX580_01390	COG1108	ABC-type Mn2 Zn2 transport systems permease components
JX580_01395	COG1121	(ABC) transporter
JX580_01400	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
JX580_01410	COG0719	Fe-S assembly protein
JX580_01415	COG0396	ATPase activity
JX580_01420	COG0719	Fe-S assembly protein
JX580_01425	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
JX580_01435	COG0745	RESPONSE REGULATOR receiver
JX580_01440	COG0840	transmembrane signaling receptor activity
JX580_01440	COG0840	transmembrane signaling receptor activity
JX580_01445	COG0784	Response regulator, receiver
JX580_01445	COG2205	protein histidine kinase activity
JX580_01470	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
JX580_01475	COG1181	Belongs to the D-alanine--D-alanine ligase family
JX580_01490	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
JX580_01500	COG0653	protein targeting
JX580_01505	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
JX580_01510	COG0352	thiamine-phosphate diphosphorylase activity
JX580_01515	COG0237	dephospho-CoA kinase activity
JX580_01520	COG0742	ribosomal rna small subunit methyltransferase
JX580_01525	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
JX580_01530	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
JX580_01540	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
JX580_01545	COG1090	epimerase
JX580_01555	COG0840	transmembrane signaling receptor activity
JX580_01565	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
JX580_01605	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
JX580_01610	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
JX580_01630	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
JX580_01635	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
JX580_01645	COG1999	signal sequence binding
JX580_01655	COG0783	Belongs to the Dps family
JX580_01660	COG0792	nuclease activity
JX580_01665	COG3107	peptidoglycan biosynthetic process
JX580_01670	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
JX580_01680	COG2001	Belongs to the MraZ family
JX580_01685	COG0275	rRNA processing
JX580_01690	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
JX580_01705	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
JX580_01710	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
JX580_01715	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
JX580_01720	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
JX580_01725	COG0772	Belongs to the SEDS family
JX580_01730	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
JX580_01740	COG3706	GGDEF domain
JX580_01745	COG0840	transmembrane signaling receptor activity
JX580_01745	COG0840	transmembrane signaling receptor activity
JX580_01755	COG0640	Transcriptional regulator
JX580_01760	COG0793	Belongs to the peptidase S41A family
JX580_01765	COG0693	protein deglycase activity
JX580_01775	COG1295	ribonuclease BN
JX580_01785	COG1385	rRNA (uridine-N3-)-methyltransferase activity
JX580_01790	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
JX580_01795	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
JX580_01825	COG0784	Response regulator, receiver
JX580_01825	COG0835	chemotaxis
JX580_01835	COG1815	bacterial-type flagellum-dependent cell motility
JX580_01855	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
JX580_01860	COG0343	queuine tRNA-ribosyltransferase activity
JX580_01865	COG1862	Preprotein translocase
JX580_01870	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
JX580_01875	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
JX580_01880	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
JX580_01910	COG1074	ATP-dependent DNA helicase activity
JX580_01925	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
JX580_01930	COG0668	transmembrane transport
JX580_01935	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
JX580_01935	COG0574	Belongs to the PEP-utilizing enzyme family
JX580_01940	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
JX580_01945	COG0352	thiamine-phosphate diphosphorylase activity
JX580_01955	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
JX580_01960	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
JX580_01965	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
JX580_01970	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
JX580_02000	COG4771	TonB-dependent receptor
JX580_02005	COG0205	6-phosphofructokinase activity
JX580_02010	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
JX580_02025	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
JX580_02030	COG1706	bacterial-type flagellum-dependent cell motility
JX580_02045	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
JX580_02055	COG1086	Polysaccharide biosynthesis protein
JX580_02060	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
JX580_02075	COG1083	cytidylyl-transferase
JX580_02085	COG0673	inositol 2-dehydrogenase activity
JX580_02090	COG2089	acid synthase
JX580_02100	COG0318	PFAM AMP-dependent synthetase and ligase
JX580_02115	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
JX580_02120	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
JX580_02125	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
JX580_02140	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
JX580_02165	COG0436	Aminotransferase
JX580_02170	COG0556	nucleotide-excision repair
JX580_02185	COG2866	Carboxypeptidase
JX580_02195	COG2204	response regulator
JX580_02205	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
JX580_02210	COG0795	lipopolysaccharide-transporting ATPase activity
JX580_02215	COG0795	lipopolysaccharide-transporting ATPase activity
JX580_02220	COG0306	phosphate transporter
JX580_02225	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
JX580_02255	COG0651	ATP synthesis coupled electron transport
JX580_02260	COG0651	ATP synthesis coupled electron transport
JX580_02265	COG0651	ATP synthesis coupled electron transport
JX580_02280	COG0330	HflC and HflK could
JX580_02295	COG0582	viral genome integration into host DNA
JX580_02370	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
JX580_02375	COG0259	pyridoxamine-phosphate oxidase activity
JX580_02400	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
JX580_02405	COG0193	aminoacyl-tRNA hydrolase activity
JX580_02410	COG0012	GTP binding
JX580_02425	COG1530	ribonuclease E activity
JX580_02430	COG0564	pseudouridine synthase activity
JX580_02440	COG0424	maF-like protein
JX580_02445	COG1399	metal-binding, possibly nucleic acid-binding protein
JX580_02450	COG0333	Belongs to the bacterial ribosomal protein bL32 family
JX580_02455	COG0416	fatty acid biosynthetic process
JX580_02460	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
JX580_02465	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
JX580_02470	COG1028	Short-chain dehydrogenase reductase Sdr
JX580_02475	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
JX580_02480	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
JX580_02485	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
JX580_02490	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
JX580_02500	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
JX580_02505	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
JX580_02510	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
JX580_02525	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
JX580_02535	COG2226	methyltransferase
JX580_02555	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
JX580_02565	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
JX580_02575	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
JX580_02580	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
JX580_02590	COG0500	methyltransferase
JX580_02605	COG4067	protein conserved in archaea
JX580_02605	COG0189	ligase activity
JX580_02610	COG0189	ligase activity
JX580_02620	COG2205	protein histidine kinase activity
JX580_02620	COG0784	Response regulator, receiver
JX580_02630	COG0784	Response regulator, receiver
JX580_02630	COG2205	protein histidine kinase activity
JX580_02640	COG5001	Diguanylate cyclase
JX580_02640	COG3300	MHYT domain
JX580_02650	COG3118	belongs to the thioredoxin family
JX580_02655	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
JX580_02665	COG0625	glutathione transferase activity
JX580_02670	COG2969	positive regulation of protein catabolic process
JX580_02690	COG3425	synthase
JX580_02695	COG1304	FMN binding
JX580_02705	COG0784	Response regulator, receiver
JX580_02705	COG2205	protein histidine kinase activity
JX580_02705	COG5002	protein histidine kinase activity
JX580_02710	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
JX580_02715	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
JX580_02720	COG0291	Belongs to the bacterial ribosomal protein bL35 family
JX580_02725	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
JX580_02730	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
JX580_02735	COG0072	phenylalanine-tRNA ligase activity
JX580_02735	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
JX580_02740	COG0776	regulation of translation
JX580_02765	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
JX580_02770	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
JX580_02775	COG1360	Flagellar Motor Protein
JX580_02785	COG0602	queuosine metabolic process
JX580_02790	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
JX580_02795	COG0066	3-isopropylmalate dehydratase activity
JX580_02800	COG0473	3-isopropylmalate dehydrogenase activity
JX580_02805	COG0739	heme binding
JX580_02815	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
JX580_02820	COG0101	tRNA pseudouridine synthase activity
JX580_02825	COG0135	phosphoribosylanthranilate isomerase activity
JX580_02830	COG0133	tryptophan synthase activity
JX580_02835	COG0159	tryptophan synthase activity
JX580_02840	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
JX580_02845	COG0285	dihydrofolate synthase activity
JX580_02865	COG1534	Rna-binding protein
JX580_02870	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
JX580_02875	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
JX580_02880	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
JX580_02885	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
JX580_02890	COG0149	triose-phosphate isomerase activity
JX580_02905	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
JX580_02910	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
JX580_02915	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
JX580_02920	COG0649	NAD binding
JX580_02925	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
JX580_02935	COG1034	ATP synthesis coupled electron transport
JX580_02940	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
JX580_02945	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
JX580_02955	COG0713	ATP synthesis coupled electron transport
JX580_02970	COG1007	ATP synthesis coupled electron transport
JX580_02990	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
JX580_03010	COG4181	ATPase activity
JX580_03025	COG1538	Outer membrane efflux protein
JX580_03065	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
JX580_03130	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
JX580_03135	COG0739	heme binding
JX580_03140	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
JX580_03140	COG0425	Belongs to the sulfur carrier protein TusA family
JX580_03150	COG0751	glycine-tRNA ligase activity
JX580_03155	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
JX580_03160	COG0204	Acyl-transferase
JX580_03160	COG0318	PFAM AMP-dependent synthetase and ligase
JX580_03175	COG1360	Flagellar Motor Protein
JX580_03185	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
JX580_03190	COG1280	lysine exporter protein (LysE YggA)
JX580_03195	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
JX580_03200	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
JX580_03205	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
JX580_03210	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
JX580_03235	COG1137	ATPase activity
JX580_03250	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
JX580_03265	COG1127	ABC transporter
JX580_03270	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
JX580_03275	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
JX580_03290	COG1131	(ABC) transporter
JX580_03295	COG0842	Transport permease protein
JX580_03305	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
JX580_03310	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
JX580_03315	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
JX580_03320	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
JX580_03325	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
JX580_03330	COG0723	plastoquinol--plastocyanin reductase activity
JX580_03335	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
JX580_03340	COG2857	Cytochrome c1
JX580_03345	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
JX580_03350	COG2205	protein histidine kinase activity
JX580_03350	COG0784	Response regulator, receiver
JX580_03360	COG4536	flavin adenine dinucleotide binding
JX580_03370	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
JX580_03375	COG0228	four-way junction DNA binding
JX580_03380	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
JX580_03385	COG0336	Belongs to the RNA methyltransferase TrmD family
JX580_03390	COG0335	large ribosomal subunit rRNA binding
JX580_03405	COG1132	(ABC) transporter
JX580_03410	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
JX580_03415	COG0521	Mo-molybdopterin cofactor biosynthetic process
JX580_03425	COG3338	carbonate dehydratase activity
JX580_03430	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
JX580_03445	COG3123	guanosine phosphorylase activity
JX580_03455	COG0180	Tryptophanyl-tRNA synthetase
JX580_03465	COG0848	biopolymer transport protein
JX580_03470	COG0811	peptide transport
JX580_03475	COG2363	Small membrane protein
JX580_03490	COG0446	pyridine nucleotide-disulphide oxidoreductase
JX580_03515	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
JX580_03530	COG0564	pseudouridine synthase activity
JX580_03535	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
JX580_03545	COG2201	protein-glutamate methylesterase activity
JX580_03550	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
JX580_03560	COG0745	RESPONSE REGULATOR receiver
JX580_03580	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
JX580_03585	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
JX580_03595	COG0084	hydrolase, TatD family'
JX580_03600	COG1132	(ABC) transporter
JX580_03625	COG3079	Belongs to the UPF0149 family
JX580_03630	COG0006	proline dipeptidase activity
JX580_03635	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
JX580_03640	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
JX580_03650	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
JX580_03655	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
JX580_03660	COG0560	Phosphoserine phosphatase
JX580_03675	COG0004	ammonium transporteR
JX580_03685	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
JX580_03725	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
JX580_03730	COG4660	Part of a membrane complex involved in electron transport
JX580_03740	COG4658	electron transport chain
JX580_03745	COG4656	Part of a membrane complex involved in electron transport
JX580_03750	COG2878	Part of a membrane complex involved in electron transport
JX580_03755	COG4657	Part of a membrane complex involved in electron transport
JX580_03760	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
JX580_03760	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
JX580_03765	COG0489	protein tyrosine kinase activity
JX580_03770	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
JX580_03775	COG0717	Belongs to the dCTP deaminase family
JX580_03785	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
JX580_03790	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
JX580_03800	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
JX580_03805	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
JX580_03835	COG0442	prolyl-tRNA aminoacylation
JX580_03840	COG0247	lactate metabolic process
JX580_03840	COG0277	FAD linked oxidase domain protein
JX580_03845	COG0424	maF-like protein
JX580_03850	COG1530	ribonuclease E activity
JX580_03880	COG3267	Type II secretory pathway component ExeA
JX580_03880	COG3409	Peptidoglycan-binding domain 1 protein
JX580_03885	COG1450	Type ii and iii secretion system protein
JX580_03895	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
JX580_03900	COG1459	type II secretion system
JX580_03920	COG2210	Belongs to the sulfur carrier protein TusA family
JX580_03925	COG2204	response regulator
JX580_03930	COG3852	Histidine kinase
JX580_03940	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
JX580_03950	COG0488	(ABC) transporter
JX580_03955	COG0587	DNA-directed DNA polymerase activity
JX580_03960	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
JX580_03970	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
JX580_03980	COG4804	nuclease activity
JX580_03995	COG0779	Required for maturation of 30S ribosomal subunits
JX580_04000	COG0195	Participates in both transcription termination and antitermination
JX580_04005	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
JX580_04010	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
JX580_04015	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
JX580_04020	COG0500	methyltransferase
JX580_04030	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
JX580_04035	COG1185	polyribonucleotide nucleotidyltransferase activity
JX580_04050	COG0542	response to heat
JX580_04070	COG4964	Belongs to the GSP D family
JX580_04120	COG4166	transmembrane transport
JX580_04125	COG0601	transmembrane transport
JX580_04130	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
JX580_04215	COG3530	Putative quorum-sensing-regulated virulence factor
JX580_04225	COG3706	GGDEF domain
JX580_04235	COG1028	Short-chain dehydrogenase reductase Sdr
JX580_04245	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
JX580_04255	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
JX580_04265	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
JX580_04270	COG0287	Prephenate dehydrogenase
JX580_04275	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
JX580_04280	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
JX580_04285	COG0539	negative regulation of cytoplasmic translation
JX580_04290	COG0776	regulation of translation
JX580_04300	COG0284	orotidine-5'-phosphate decarboxylase activity
JX580_04305	COG0360	Binds together with S18 to 16S ribosomal RNA
JX580_04310	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
JX580_04320	COG0359	binds to the 23S rRNA
JX580_04325	COG0573	inorganic phosphate transmembrane transporter activity
JX580_04330	COG0581	inorganic phosphate transmembrane transporter activity
JX580_04335	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
JX580_04340	COG0704	Plays a role in the regulation of phosphate uptake
JX580_04345	COG0745	RESPONSE REGULATOR receiver
JX580_04360	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
JX580_04385	COG0737	Belongs to the 5'-nucleotidase family
JX580_04390	COG0840	transmembrane signaling receptor activity
JX580_04395	COG3706	GGDEF domain
JX580_04395	COG4251	negative regulation of phosphorylation
JX580_04395	COG5001	Diguanylate cyclase
JX580_04395	COG2203	Gaf domain
JX580_04400	COG0058	SHG alpha-glucan phosphorylase activity
JX580_04410	COG0675	Transposase, IS605 OrfB family
JX580_04415	COG0058	SHG alpha-glucan phosphorylase activity
JX580_04420	COG0469	pyruvate kinase activity
JX580_04430	COG0438	transferase activity, transferring glycosyl groups
JX580_04445	COG0675	Transposase, IS605 OrfB family
JX580_04455	COG0582	viral genome integration into host DNA
JX580_04510	COG0840	transmembrane signaling receptor activity
JX580_04510	COG0840	transmembrane signaling receptor activity
JX580_04515	COG0784	Response regulator, receiver
JX580_04515	COG0835	chemotaxis
JX580_04535	COG4999	Histidine kinase
JX580_04535	COG2205	protein histidine kinase activity
JX580_04535	COG3850	Histidine kinase
JX580_04535	COG3437	response regulator, receiver
JX580_04550	COG5001	Diguanylate cyclase
JX580_04555	COG0840	transmembrane signaling receptor activity
JX580_04625	COG0432	Pfam Uncharacterised protein family UPF0047
JX580_04635	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
JX580_04645	COG0495	leucyl-tRNA aminoacylation
JX580_04660	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
JX580_04680	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
JX580_04695	COG0257	Belongs to the bacterial ribosomal protein bL36 family
JX580_04700	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
JX580_04720	COG2204	response regulator
JX580_04725	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
JX580_04730	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
JX580_04735	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
JX580_04765	COG1739	Uncharacterized protein family UPF0029
JX580_04770	COG2183	response to ionizing radiation
JX580_04775	COG4232	protein-disulfide reductase activity
JX580_04780	COG3030	protein affecting phage T7 exclusion by the F plasmid
JX580_04790	COG0500	methyltransferase
JX580_04795	COG0701	Predicted permease
JX580_04805	COG0746	molybdenum cofactor guanylyltransferase activity
JX580_04810	COG0303	'Molybdopterin
JX580_04815	COG2197	response regulator
JX580_04825	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
JX580_04835	COG1199	ATP-dependent helicase activity
JX580_04850	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
JX580_04875	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
JX580_04880	COG0481	GTPase activity
JX580_04895	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
JX580_04900	COG1381	Involved in DNA repair and RecF pathway recombination
JX580_04905	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
JX580_04910	COG0736	holo-[acyl-carrier-protein] synthase activity
JX580_04920	COG5001	Diguanylate cyclase
JX580_04925	COG0492	ferredoxin-NADP+ reductase activity
JX580_04930	COG1674	ftsk spoiiie
JX580_04935	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
JX580_04940	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
JX580_04945	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
JX580_04950	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
JX580_04960	COG0582	viral genome integration into host DNA
JX580_04970	COG2337	Toxic component of a toxin-antitoxin (TA) module
JX580_04975	COG3657	addiction module killer protein
JX580_05015	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
JX580_05065	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
JX580_05110	COG1215	transferase activity, transferring glycosyl groups
JX580_05180	COG2801	Transposase and inactivated derivatives
JX580_05205	COG0438	transferase activity, transferring glycosyl groups
JX580_05205	COG1216	Glycosyl transferase, family 2
JX580_05210	COG0175	sulfate reduction
JX580_05215	COG2895	sulfate adenylyltransferase (ATP) activity
JX580_05220	COG0471	metal ion transport
JX580_05220	COG3273	potassium ion transport
JX580_05225	COG0529	Catalyzes the synthesis of activated sulfate
JX580_05250	COG2801	Transposase and inactivated derivatives
JX580_05265	COG0347	Belongs to the P(II) protein family
JX580_05270	COG0688	phosphatidylethanolamine metabolic process
JX580_05275	COG0137	argininosuccinate synthase activity
JX580_05280	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
JX580_05285	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
JX580_05290	COG1301	dicarboxylic acid transport
JX580_05300	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
JX580_05305	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
JX580_05315	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
JX580_05320	COG0215	cysteine-tRNA ligase activity
JX580_05325	COG0741	lytic transglycosylase activity
JX580_05330	COG0741	lytic transglycosylase activity
JX580_05330	COG1388	LysM domain
JX580_05335	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
JX580_05345	COG0328	RNA-DNA hybrid ribonuclease activity
JX580_05365	COG1570	exodeoxyribonuclease VII activity
JX580_05370	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
JX580_05375	COG1671	Belongs to the UPF0178 family
JX580_05385	COG0840	transmembrane signaling receptor activity
JX580_05390	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
JX580_05400	COG0668	transmembrane transport
JX580_05405	COG1116	anion transmembrane transporter activity
JX580_05415	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
JX580_05435	COG1487	ribonuclease activity
JX580_05445	COG1724	mRNA binding
JX580_05450	COG1598	PFAM Uncharacterised protein family UPF0150
JX580_05455	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
JX580_05470	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
JX580_05485	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
JX580_05490	COG0511	ligase activity, forming carbon-carbon bonds
JX580_05495	COG0439	Biotin carboxylase
JX580_05500	COG2264	protein methyltransferase activity
JX580_05505	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
JX580_05515	COG0138	bifunctional purine biosynthesis protein purh
JX580_05530	COG0363	glucosamine-6-phosphate deaminase activity
JX580_05535	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
JX580_05575	COG2954	triphosphatase activity
JX580_05590	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
JX580_05595	COG2226	methyltransferase
JX580_05600	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
JX580_05610	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
JX580_05640	COG2801	Transposase and inactivated derivatives
JX580_05680	COG2801	Transposase and inactivated derivatives
JX580_05705	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
JX580_05710	COG4804	nuclease activity
JX580_05715	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
JX580_05740	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
JX580_05745	COG0438	transferase activity, transferring glycosyl groups
JX580_05775	COG1091	dTDP-4-dehydrorhamnose reductase activity
JX580_05780	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
JX580_05800	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
JX580_05810	COG2801	Transposase and inactivated derivatives
JX580_05830	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
JX580_05835	COG0148	phosphopyruvate hydratase activity
JX580_05840	COG2877	3-deoxy-8-phosphooctulonate synthase activity
JX580_05845	COG0504	CTP synthase activity
JX580_05850	COG0037	tRNA processing
JX580_05855	COG0825	malonyl-CoA metabolic process
JX580_05865	COG1944	ATP diphosphatase activity
JX580_05875	COG3012	SEC-C Motif Domain Protein
JX580_05880	COG0534	Mate efflux family protein
JX580_05890	COG0494	nUDIX hydrolase
JX580_05895	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
JX580_05920	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
JX580_05925	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
JX580_05930	COG1994	Peptidase M50
JX580_05935	COG0009	L-threonylcarbamoyladenylate synthase
JX580_05940	COG1067	ATP-dependent peptidase activity
JX580_05945	COG2515	1-aminocyclopropane-1-carboxylate deaminase
JX580_05955	COG1643	Atp-dependent helicase
JX580_05980	COG4115	mRNA cleavage
JX580_05985	COG2161	toxin-antitoxin pair type II binding
JX580_06005	COG1047	Peptidyl-prolyl cis-trans
JX580_06010	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
JX580_06030	COG0745	RESPONSE REGULATOR receiver
JX580_06055	COG0589	response to stress
JX580_06070	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
JX580_06085	COG1981	membrane
JX580_06090	COG1047	Peptidyl-prolyl cis-trans
JX580_06095	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
JX580_06110	COG2983	Belongs to the UPF0260 family
JX580_06115	COG0564	pseudouridine synthase activity
JX580_06120	COG4335	DNA alkylation repair
JX580_06130	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
JX580_06135	COG0517	IMP dehydrogenase activity
JX580_06145	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
JX580_06150	COG1984	allophanate hydrolase subunit 2
JX580_06165	COG3852	Histidine kinase
JX580_06180	COG0803	Belongs to the bacterial solute-binding protein 9 family
JX580_06185	COG1121	(ABC) transporter
JX580_06190	COG1108	ABC-type Mn2 Zn2 transport systems permease components
JX580_06190	COG1321	iron dependent repressor
JX580_06195	COG1108	ABC-type Mn2 Zn2 transport systems permease components
JX580_06200	COG3706	GGDEF domain
JX580_06205	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
JX580_06225	COG0659	secondary active sulfate transmembrane transporter activity
JX580_06240	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
JX580_06245	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
JX580_06255	COG2239	Acts as a magnesium transporter
JX580_06265	COG0436	Aminotransferase
JX580_06280	COG1238	metal cluster binding
JX580_06285	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
JX580_06290	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
JX580_06305	COG1917	Cupin 2, conserved barrel domain protein
JX580_06310	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
JX580_06320	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
JX580_06325	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
JX580_06330	COG2890	protein-(glutamine-N5) methyltransferase activity
JX580_06335	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
JX580_06365	COG0658	competence protein
JX580_06365	COG2333	competence protein COMEC
JX580_06375	COG0613	PHP domain protein
JX580_06380	COG2917	probably involved in intracellular septation
JX580_06385	COG2350	Protein conserved in bacteria
JX580_06390	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
JX580_06395	COG0252	asparaginase activity
JX580_06405	COG3028	Belongs to the UPF0307 family
JX580_06410	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
JX580_06420	COG1196	nuclear chromosome segregation
JX580_06430	COG1070	Carbohydrate kinase
JX580_06440	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
JX580_06445	COG0484	heat shock protein binding
JX580_06450	COG0443	Heat shock 70 kDa protein
JX580_06455	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
JX580_06460	COG0525	valine-tRNA ligase activity
JX580_06475	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
JX580_06490	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
JX580_06500	COG2945	thiolester hydrolase activity
JX580_06505	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
JX580_06510	COG3439	Domain of unknown function DUF302
JX580_06550	COG0732	type I restriction modification DNA specificity domain
JX580_06560	COG1278	Cold shock
JX580_06590	COG3217	Mosc domain protein beta barrel domain protein
JX580_06590	COG0633	Ferredoxin
JX580_06600	COG0322	excinuclease ABC activity
JX580_06625	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
JX580_06635	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
JX580_06640	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
JX580_06645	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
JX580_06650	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
JX580_06655	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
JX580_06665	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
JX580_06670	COG0750	zinc metalloprotease
JX580_06675	COG0575	Belongs to the CDS family
JX580_06685	COG0233	cytoplasmic translational termination
JX580_06690	COG0528	UMP kinase activity
JX580_06695	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
JX580_06700	COG0052	Belongs to the universal ribosomal protein uS2 family
JX580_06705	COG0024	Methionine aminopeptidase
JX580_06710	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
JX580_06725	COG1393	Belongs to the ArsC family
JX580_06730	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
JX580_06745	COG0733	neurotransmitter:sodium symporter activity
JX580_06755	COG1472	Belongs to the glycosyl hydrolase 3 family
JX580_06760	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
JX580_06770	COG1376	ErfK ybiS ycfS ynhG family protein
JX580_06775	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
JX580_06775	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
JX580_06780	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
JX580_06785	COG0045	succinate-CoA ligase (ADP-forming) activity
JX580_06805	COG2731	YhcH YjgK YiaL family protein
JX580_06825	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
JX580_06830	COG2835	tetraacyldisaccharide 4'-kinase activity
JX580_06835	COG1663	tetraacyldisaccharide 4'-kinase activity
JX580_06840	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
JX580_06855	COG1053	succinate dehydrogenase
JX580_06870	COG2205	protein histidine kinase activity
JX580_06870	COG0784	Response regulator, receiver
JX580_06880	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
JX580_06885	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
JX580_06900	COG2850	peptidyl-arginine hydroxylation
JX580_06930	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
JX580_06935	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
JX580_06940	COG0740	serine-type endopeptidase activity
JX580_06945	COG0544	peptidyl-prolyl cis-trans isomerase activity
JX580_06955	COG0488	(ABC) transporter
JX580_06960	COG1136	(ABC) transporter
JX580_06965	COG4591	ABC-type transport system involved in lipoprotein release permease component
JX580_06975	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
JX580_06985	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
JX580_06990	COG2894	cell division
JX580_06995	COG0850	regulation of cytokinetic process
JX580_07010	COG3023	N-Acetylmuramoyl-L-alanine amidase
JX580_07045	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
JX580_07050	COG0826	peptidase U32
JX580_07070	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
JX580_07075	COG0508	dehydrogenase complex catalyzes the overall conversion of
JX580_07080	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
JX580_07085	COG1051	belongs to the nudix hydrolase family
JX580_07100	COG1940	carbohydrate kinase activity
JX580_07105	COG2833	Protein of unknown function (DUF455)
JX580_07115	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
JX580_07125	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
JX580_07140	COG0823	Involved in the tonB-independent uptake of proteins
JX580_07150	COG0848	biopolymer transport protein
JX580_07160	COG2255	four-way junction helicase activity
JX580_07165	COG0632	four-way junction helicase activity
JX580_07170	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
JX580_07180	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
JX580_07185	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
JX580_07195	COG0300	oxidoreductase activity
JX580_07200	COG0142	geranyltranstransferase activity
JX580_07205	COG0720	synthase
JX580_07210	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
JX580_07220	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
JX580_07225	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
JX580_07230	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
JX580_07235	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
JX580_07240	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
JX580_07255	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
JX580_07255	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
JX580_07260	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
JX580_07265	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
JX580_07270	COG0488	(ABC) transporter
JX580_07275	COG2199	diguanylate cyclase activity
JX580_07290	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
JX580_07290	COG1648	precorrin-2 dehydrogenase activity
JX580_07295	COG0243	molybdopterin cofactor binding
JX580_07305	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
JX580_07310	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
JX580_07315	COG1116	anion transmembrane transporter activity
JX580_07320	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
JX580_07325	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
JX580_07330	COG3707	response regulator
JX580_07355	COG1011	Hydrolase
JX580_07360	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
JX580_07365	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
JX580_07390	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
JX580_07425	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
JX580_07430	COG2197	response regulator
JX580_07450	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
JX580_07450	COG0116	Belongs to the methyltransferase superfamily
JX580_07480	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
JX580_07485	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
JX580_07490	COG0196	riboflavin kinase activity
JX580_07495	COG3530	Putative quorum-sensing-regulated virulence factor
JX580_07540	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
JX580_07545	COG0028	Belongs to the TPP enzyme family
JX580_07555	COG0268	Binds directly to 16S ribosomal RNA
JX580_07560	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
JX580_07570	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
JX580_07575	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
JX580_07575	COG2169	Transcriptional regulator
JX580_07585	COG1496	oxidoreductase activity
JX580_07590	COG0564	pseudouridine synthase activity
JX580_07600	COG0004	ammonium transporteR
JX580_07605	COG0271	Belongs to the BolA IbaG family
JX580_07615	COG0633	Ferredoxin
JX580_07620	COG0174	glutamine synthetase
JX580_07645	COG1492	cobalamin metabolic process
JX580_07665	COG3093	addiction module antidote protein HigA
JX580_07675	COG0330	HflC and HflK could
JX580_07690	COG4681	YaeQ
JX580_07695	COG4628	conserved protein (DUF2132)
JX580_07700	COG3228	Belongs to the MtfA family
JX580_07715	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
JX580_07720	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
JX580_07725	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
JX580_07745	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
JX580_07760	COG0527	aspartate kinase activity
JX580_07765	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
JX580_07775	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
JX580_07780	COG1546	Belongs to the CinA family
JX580_07785	COG0058	SHG alpha-glucan phosphorylase activity
JX580_07790	COG0297	glycogen (starch) synthase activity
JX580_07795	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
JX580_07810	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
JX580_07815	COG0837	glucose binding
JX580_07820	COG0517	IMP dehydrogenase activity
JX580_07820	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
JX580_07830	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
JX580_07835	COG3178	'Phosphotransferase
JX580_07840	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
JX580_07845	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
JX580_07845	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
JX580_07850	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
JX580_07855	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
JX580_07860	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
JX580_07870	COG0815	Transfers the fatty acyl group on membrane lipoproteins
JX580_07875	COG4535	Mg2 and Co2 transporter CorC
JX580_07885	COG1702	phosphate starvation-inducible protein PhoH
JX580_07890	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
JX580_07895	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
JX580_07900	COG2863	cytochrome
JX580_07905	COG0446	pyridine nucleotide-disulphide oxidoreductase
JX580_07920	COG0232	Belongs to the dGTPase family. Type 2 subfamily
JX580_07930	COG0326	Molecular chaperone. Has ATPase activity
JX580_07940	COG2198	Histidine kinase
JX580_07940	COG0643	Histidine kinase
JX580_07945	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
JX580_07950	COG0590	tRNA wobble adenosine to inosine editing
JX580_07955	COG0518	GMP synthase (glutamine-hydrolyzing) activity
JX580_07955	COG0519	Catalyzes the synthesis of GMP from XMP
JX580_07975	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
JX580_07980	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
JX580_07985	COG0497	DNA recombination
JX580_07995	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
JX580_08000	COG2914	Belongs to the UPF0125 (RnfH) family
JX580_08005	COG2867	negative regulation of translational initiation
JX580_08010	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
JX580_08025	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
JX580_08030	COG0322	excinuclease ABC activity
JX580_08045	COG0415	Belongs to the DNA photolyase family
JX580_08065	COG1620	l-lactate permease
JX580_08070	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
JX580_08080	COG0542	response to heat
JX580_08085	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
JX580_08090	COG0484	heat shock protein binding
JX580_08095	COG1187	pseudouridine synthase activity
JX580_08100	COG0482	sulfurtransferase activity
JX580_08105	COG2915	High frequency lysogenization protein hflD homolog
JX580_08110	COG0784	Response regulator, receiver
JX580_08110	COG2205	protein histidine kinase activity
JX580_08110	COG5002	protein histidine kinase activity
JX580_08120	COG0784	Response regulator, receiver
JX580_08120	COG0835	chemotaxis
JX580_08125	COG0840	transmembrane signaling receptor activity
JX580_08150	COG2165	general secretion pathway protein
JX580_08165	COG0358	DNA primase activity
JX580_08175	COG0828	Belongs to the bacterial ribosomal protein bS21 family
JX580_08180	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
JX580_08185	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
JX580_08200	COG1968	undecaprenyl-diphosphatase activity
JX580_08210	COG2239	Acts as a magnesium transporter
JX580_08215	COG1285	pathogenesis
JX580_08220	COG2239	Acts as a magnesium transporter
JX580_08225	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
JX580_08230	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
JX580_08240	COG0330	HflC and HflK could
JX580_08245	COG0330	HflC and HflK could
JX580_08250	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
JX580_08255	COG1923	regulation of RNA biosynthetic process
JX580_08260	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
JX580_08265	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
JX580_08270	COG0860	N-Acetylmuramoyl-L-alanine amidase
JX580_08275	COG0802	atpase or kinase
JX580_08280	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
JX580_08290	COG0643	Histidine kinase
JX580_08290	COG0784	Response regulator, receiver
JX580_08290	COG2198	Histidine kinase
JX580_08295	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
JX580_08320	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
JX580_08390	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
JX580_08400	COG1677	Flagellar hook-basal body complex protein FliE
JX580_08435	COG0308	aminopeptidase N
JX580_08440	COG2885	chlorophyll binding
JX580_08445	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
JX580_08455	COG1678	Uncharacterized ACR, COG1678
JX580_08460	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
JX580_08465	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
JX580_08470	COG0540	Belongs to the ATCase OTCase family
JX580_08475	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
JX580_08540	COG1459	type II secretion system
JX580_08545	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
JX580_08565	COG2391	methyltransferase activity
JX580_08570	COG0579	oxidoreductase
JX580_08575	COG0523	cobalamin synthesis protein
JX580_08580	COG1469	GTP cyclohydrolase I activity
JX580_08590	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
JX580_08605	COG0762	integral membrane protein
JX580_08610	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
JX580_08630	COG2003	Belongs to the UPF0758 family
JX580_08635	COG0227	Belongs to the bacterial ribosomal protein bL28 family
JX580_08645	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
JX580_08645	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
JX580_08675	COG2308	Evidence 4 Homologs of previously reported genes of
JX580_08680	COG0189	ligase activity
JX580_08685	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
JX580_08690	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
JX580_08695	COG0557	exoribonuclease II activity
JX580_08700	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
JX580_08705	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
JX580_08705	COG0301	tRNA thio-modification
JX580_08710	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
JX580_08715	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
JX580_08720	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
JX580_08725	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
JX580_08735	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
JX580_08740	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
JX580_08745	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
JX580_08750	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
JX580_08755	COG0617	tRNA 3'-terminal CCA addition
JX580_08765	COG0501	Belongs to the peptidase M48B family
JX580_08770	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
JX580_08775	COG0154	amidase activity
JX580_08780	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
JX580_08785	COG1077	Cell shape determining protein MreB Mrl
JX580_08790	COG1792	Involved in formation and maintenance of cell shape
JX580_08800	COG0768	penicillin binding
JX580_08805	COG0772	Belongs to the SEDS family
JX580_08810	COG1686	Belongs to the peptidase S11 family
JX580_08825	COG0321	lipoyl(octanoyl) transferase activity
JX580_08830	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
JX580_08840	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
JX580_08850	COG2200	EAL domain
JX580_08865	COG3022	response to hydroperoxide
JX580_08875	COG1162	GTPase activity
JX580_08895	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
JX580_08910	COG0840	transmembrane signaling receptor activity
JX580_08915	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
JX580_08920	COG1012	belongs to the aldehyde dehydrogenase family
JX580_08930	COG0509	glycine decarboxylation via glycine cleavage system
JX580_08945	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
JX580_08950	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
JX580_09000	COG3177	Filamentation induced by cAMP protein fic
JX580_09015	COG2154	pterin-4-alpha-carbinolamine dehydratase
JX580_09020	COG0501	Belongs to the peptidase M48B family
JX580_09025	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
JX580_09030	COG0028	Belongs to the TPP enzyme family
JX580_09040	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
JX580_09050	COG0277	FAD linked oxidase domain protein
JX580_09055	COG1160	GTP binding
JX580_09060	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
JX580_09065	COG2976	Protein conserved in bacteria
JX580_09070	COG0124	histidyl-tRNA synthetase
JX580_09080	COG0820	rRNA (adenine-C2-)-methyltransferase activity
JX580_09085	COG0105	UTP biosynthetic process
JX580_09090	COG0316	Belongs to the HesB IscA family
JX580_09095	COG1959	2 iron, 2 sulfur cluster binding
JX580_09115	COG0456	acetyltransferase
JX580_09125	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
JX580_09130	COG1183	phosphatidylcholine synthase activity
JX580_09140	COG0166	Belongs to the GPI family
JX580_09145	COG1210	Utp--glucose-1-phosphate uridylyltransferase
JX580_09155	COG4783	chaperone-mediated protein folding
JX580_09175	COG3258	Cytochrome c
JX580_09185	COG0129	dihydroxy-acid dehydratase activity
JX580_09190	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
JX580_09190	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
JX580_09195	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
JX580_09200	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
JX580_09205	COG0367	asparagine synthase
JX580_09210	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
JX580_09220	COG1858	cytochrome C peroxidase
JX580_09225	COG0514	ATP-dependent DNA helicase (RecQ)
JX580_09230	COG0513	Belongs to the DEAD box helicase family
JX580_09250	COG0612	Peptidase, M16
JX580_09255	COG0612	Peptidase, M16
JX580_09260	COG0552	protein localization to endoplasmic reticulum
JX580_09270	COG0459	protein refolding
JX580_09285	COG2199	diguanylate cyclase activity
JX580_09285	COG2200	EAL domain
JX580_09285	COG2202	Pas domain
JX580_09290	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
JX580_09310	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
JX580_09315	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
JX580_09320	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
JX580_09320	COG3264	Mechanosensitive ion channel
JX580_09335	COG0477	Major facilitator Superfamily
JX580_09340	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
JX580_09345	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
JX580_09350	COG0211	Belongs to the bacterial ribosomal protein bL27 family
JX580_09355	COG0261	This protein binds to 23S rRNA in the presence of protein L20
JX580_09360	COG0142	geranyltranstransferase activity
JX580_09375	COG2814	Major facilitator Superfamily
JX580_09385	COG3046	protein related to deoxyribodipyrimidine photolyase
JX580_09395	COG0415	Belongs to the DNA photolyase family
JX580_09400	COG0784	Response regulator, receiver
JX580_09400	COG2205	protein histidine kinase activity
JX580_09420	COG4683	PFAM Phage derived protein Gp49-like (DUF891)
JX580_09480	COG0628	permease
JX580_09485	COG3550	peptidyl-serine autophosphorylation
JX580_09490	COG1396	sequence-specific DNA binding
JX580_09510	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
JX580_09520	COG0157	Belongs to the NadC ModD family
JX580_09525	COG1120	ATPase activity
JX580_09530	COG3585	molybdate ion transport
JX580_09535	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
JX580_09540	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
JX580_09585	COG5642	Protein of unknown function (DUF2384)
JX580_09600	COG0778	Nitroreductase
JX580_09605	COG0133	tryptophan synthase activity
JX580_09615	COG2062	phosphohistidine phosphatase, SixA
JX580_09630	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
JX580_09635	COG0248	Ppx GppA phosphatase
JX580_09640	COG0840	transmembrane signaling receptor activity
JX580_09655	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
JX580_09730	COG0583	DNA-binding transcription factor activity
JX580_09750	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
JX580_09775	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
JX580_09800	COG1280	lysine exporter protein (LysE YggA)
JX580_09815	COG0450	alkyl hydroperoxide reductase
JX580_09840	COG1280	lysine exporter protein (LysE YggA)
JX580_09885	COG0784	Response regulator, receiver
JX580_09885	COG2205	protein histidine kinase activity
JX580_09885	COG5002	protein histidine kinase activity
JX580_09895	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
JX580_09915	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
JX580_09920	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
JX580_09940	COG0756	dUTP diphosphatase activity
JX580_09955	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
JX580_09975	COG0019	diaminopimelate decarboxylase activity
JX580_09990	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
JX580_09995	COG0084	hydrolase, TatD family'
JX580_10000	COG0203	ribosomal protein L17
JX580_10005	COG0202	RNA polymerase activity
JX580_10010	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
JX580_10015	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
JX580_10020	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
JX580_10025	COG0201	protein transport
JX580_10030	COG0200	Binds to the 23S rRNA
JX580_10035	COG1841	ribosomal large subunit assembly
JX580_10040	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
JX580_10045	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
JX580_10050	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
JX580_10055	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
JX580_10060	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
JX580_10065	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
JX580_10070	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
JX580_10080	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
JX580_10085	COG0255	Belongs to the universal ribosomal protein uL29 family
JX580_10090	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
JX580_10095	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
JX580_10100	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
JX580_10105	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
JX580_10115	COG0089	rRNA binding
JX580_10120	COG0088	Forms part of the polypeptide exit tunnel
JX580_10125	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
JX580_10130	COG0051	transcription antitermination factor activity, RNA binding
JX580_10135	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
JX580_10140	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
JX580_10145	COG0049	tRNA binding
JX580_10150	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
JX580_10155	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
JX580_10160	COG0085	RNA polymerase activity
JX580_10165	COG0222	ribosome binding
JX580_10170	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
JX580_10175	COG0081	regulation of translation
JX580_10180	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
JX580_10190	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
JX580_10200	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
JX580_10220	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
JX580_10225	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
JX580_10230	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
JX580_10235	COG1765	OsmC-like protein
JX580_10240	COG0134	indole-3-glycerol-phosphate synthase activity
JX580_10245	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
JX580_10260	COG0546	phosphoglycolate phosphatase activity
JX580_10265	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
JX580_10275	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
JX580_10280	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
JX580_10305	COG0606	chelatase, subunit chli
JX580_10315	COG3706	GGDEF domain
JX580_10325	COG0018	arginyl-trna synthetase
JX580_10335	COG0758	DNA mediated transformation
JX580_10340	COG0242	peptide deformylase activity
JX580_10345	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
JX580_10360	COG5000	phosphorelay sensor kinase activity
JX580_10365	COG2204	response regulator
JX580_10370	COG0569	domain protein
JX580_10375	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
JX580_10385	COG2217	Heavy metal translocating P-type atpase
JX580_10415	COG3278	Belongs to the heme-copper respiratory oxidase family
JX580_10420	COG0131	Imidazoleglycerol-phosphate dehydratase
JX580_10425	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
JX580_10430	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
JX580_10435	COG0107	imidazoleglycerol-phosphate synthase activity
JX580_10440	COG0140	phosphoribosyl-ATP diphosphatase activity
JX580_10445	COG0537	adenosine 5'-monophosphoramidase activity
JX580_10450	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
JX580_10455	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
JX580_10460	COG0805	protein transport
JX580_10480	COG3094	Invasion gene expression up-regulator, SirB
JX580_10485	COG2226	methyltransferase
JX580_10490	COG0596	Alpha beta hydrolase
JX580_10495	COG1278	Cold shock
JX580_10505	COG3706	GGDEF domain
JX580_10510	COG0156	8-amino-7-oxononanoate synthase activity
JX580_10515	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
JX580_10520	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
JX580_10525	COG0194	GDP metabolic process
JX580_10560	COG2081	HI0933 family
JX580_10565	COG1058	Belongs to the CinA family
JX580_10565	COG1546	Belongs to the CinA family
JX580_10580	COG0446	pyridine nucleotide-disulphide oxidoreductase
JX580_10595	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
JX580_10595	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
JX580_10605	COG1444	tRNA N-acetyltransferase activity
JX580_10610	COG0788	formyltetrahydrofolate deformylase activity
JX580_10635	COG0033	Phosphoglucomutase
JX580_10645	COG5001	Diguanylate cyclase
JX580_10645	COG3706	GGDEF domain
JX580_10645	COG4251	negative regulation of phosphorylation
JX580_10645	COG2203	Gaf domain
JX580_10655	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
JX580_10665	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
JX580_10675	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
JX580_10680	COG0220	tRNA (guanine-N7-)-methyltransferase activity
JX580_10695	COG0563	adenylate kinase activity
JX580_10700	COG0840	transmembrane signaling receptor activity
JX580_10705	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
JX580_10710	COG0709	Synthesizes selenophosphate from selenide and ATP
JX580_10715	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
JX580_10720	COG1262	PFAM Formylglycine-generating sulfatase enzyme
JX580_10730	COG5001	Diguanylate cyclase
JX580_10755	COG2205	protein histidine kinase activity
JX580_10755	COG0784	Response regulator, receiver
JX580_10760	COG1854	S-ribosylhomocysteine lyase activity
JX580_10765	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
JX580_10770	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
JX580_10800	COG0745	RESPONSE REGULATOR receiver
JX580_10820	COG2852	Protein conserved in bacteria
JX580_10825	COG0730	response to heat
JX580_10830	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
JX580_10835	COG2205	protein histidine kinase activity
JX580_10835	COG5002	protein histidine kinase activity
JX580_10835	COG0784	Response regulator, receiver
JX580_10840	COG0745	RESPONSE REGULATOR receiver
JX580_10845	COG3437	response regulator, receiver
JX580_10860	COG3609	addiction module antidote protein, CC2985 family
JX580_10870	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
JX580_10885	COG2022	thiamine diphosphate biosynthetic process
JX580_10890	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
JX580_10895	COG3038	cytochrome b561
JX580_10905	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
JX580_10915	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
JX580_10920	COG0355	proton-transporting ATP synthase activity, rotational mechanism
JX580_10925	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
JX580_10930	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
JX580_10935	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
JX580_10940	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
JX580_10945	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
JX580_10950	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
JX580_10955	COG0356	it plays a direct role in the translocation of protons across the membrane
JX580_10975	COG1192	Involved in chromosome partitioning
JX580_10980	COG0357	Ribosomal RNA small subunit methyltransferase G
JX580_10985	COG0445	tRNA wobble uridine modification
JX580_11005	COG0840	transmembrane signaling receptor activity
JX580_11010	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
JX580_11010	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
JX580_11040	COG4771	TonB-dependent receptor
JX580_11050	COG1528	Iron-storage protein
JX580_11055	COG4772	TonB-dependent receptor
JX580_11065	COG3300	MHYT domain
JX580_11065	COG5001	Diguanylate cyclase
JX580_11070	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
JX580_11085	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
JX580_11090	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
JX580_11105	COG4206	TonB-dependent receptor
JX580_11110	COG0748	coenzyme F420 binding
JX580_11125	COG1116	anion transmembrane transporter activity
JX580_11125	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
JX580_11130	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
JX580_11135	COG1116	anion transmembrane transporter activity
JX580_11140	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
JX580_11170	COG0741	lytic transglycosylase activity
JX580_11175	COG0488	(ABC) transporter
JX580_11180	COG0492	ferredoxin-NADP+ reductase activity
JX580_11190	COG1741	Belongs to the pirin family
JX580_11195	COG0583	DNA-binding transcription factor activity
JX580_11205	COG2226	methyltransferase
JX580_11210	COG0500	methyltransferase
JX580_11215	COG0745	RESPONSE REGULATOR receiver
JX580_11225	COG0714	Associated with various cellular activities
JX580_11245	COG2304	oxidoreductase activity
JX580_11255	COG0840	transmembrane signaling receptor activity
JX580_11275	COG3667	copper resistance
JX580_11280	COG2132	Multicopper oxidase
JX580_11285	COG2161	toxin-antitoxin pair type II binding
JX580_11295	COG0745	RESPONSE REGULATOR receiver
JX580_11310	COG5002	protein histidine kinase activity
JX580_11355	COG2304	oxidoreductase activity
JX580_11375	COG0714	Associated with various cellular activities
JX580_11390	COG1136	(ABC) transporter
JX580_11395	COG0390	transport system, permease component
JX580_11400	COG2199	diguanylate cyclase activity
JX580_11400	COG2203	Gaf domain
JX580_11435	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
JX580_11435	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
JX580_11445	COG3001	Fructosamine kinase
JX580_11455	COG0243	molybdopterin cofactor binding
JX580_11480	COG2133	pyrroloquinoline quinone binding
JX580_11485	COG2337	Toxic component of a toxin-antitoxin (TA) module
JX580_11540	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
JX580_11545	COG1136	(ABC) transporter
JX580_11545	COG0577	efflux transmembrane transporter activity
JX580_11565	COG2026	Addiction module toxin, RelE StbE family
JX580_11570	COG3077	Addiction module antitoxin, RelB DinJ family
JX580_11600	COG3093	addiction module antidote protein HigA
JX580_11615	COG0561	phosphatase activity
JX580_11620	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
JX580_11625	COG2853	Lipoprotein
JX580_11630	COG0583	DNA-binding transcription factor activity
JX580_11635	COG0778	Nitroreductase
JX580_11650	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
JX580_11655	COG1333	cytochrome c biogenesis protein
JX580_11660	COG0218	Necessary for normal cell division and for the maintenance of normal septation
JX580_11665	COG0501	Belongs to the peptidase M48B family
JX580_11670	COG0408	coproporphyrinogen oxidase activity
JX580_11675	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
JX580_11695	COG0187	DNA topoisomerase II activity
JX580_11740	COG0165	Argininosuccinate lyase
JX580_11755	COG0181	hydroxymethylbilane synthase activity
JX580_11780	COG3300	MHYT domain
JX580_11780	COG5001	Diguanylate cyclase
JX580_11790	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
JX580_11790	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
JX580_11800	COG0009	L-threonylcarbamoyladenylate synthase
JX580_11805	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
JX580_11820	COG3842	ATPase activity
JX580_11825	COG4999	Histidine kinase
JX580_11825	COG2205	protein histidine kinase activity
JX580_11825	COG3437	response regulator, receiver
JX580_11825	COG3850	Histidine kinase
JX580_11830	COG3118	belongs to the thioredoxin family
JX580_11845	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
JX580_11865	COG0840	transmembrane signaling receptor activity
JX580_11870	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
JX580_11890	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
JX580_11895	COG0230	Belongs to the bacterial ribosomal protein bL34 family
JX580_11900	COG0594	ribonuclease P activity
JX580_11905	COG0706	membrane insertase activity
JX580_11910	COG0730	response to heat