locus-tag	class	description
Tint_0001	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
Tint_0002	COG0592	DNA-directed DNA polymerase activity
Tint_0005	COG3383	formate dehydrogenase (NAD+) activity
Tint_0006	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
Tint_0007	COG0837	glucose binding
Tint_0009	COG0800	Aldolase
Tint_0012	COG1294	oxidase, subunit
Tint_0013	COG1271	oxidase subunit
Tint_0015	COG1230	cation diffusion facilitator family transporter
Tint_0021	COG0752	glycyl-tRNA synthetase alpha subunit
Tint_0022	COG0751	glycine-tRNA ligase activity
Tint_0023	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
Tint_0027	COG0346	lactoylglutathione lyase activity
Tint_0031	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
Tint_0034	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
Tint_0036	COG0735	belongs to the Fur family
Tint_0037	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
Tint_0043	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
Tint_0048	COG2391	methyltransferase activity
Tint_0049	COG2391	methyltransferase activity
Tint_0051	COG2204	response regulator
Tint_0053	COG2205	protein histidine kinase activity
Tint_0054	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
Tint_0055	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
Tint_0056	COG3422	double-strand break repair
Tint_0059	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
Tint_0060	COG4988	ABC transporter
Tint_0065	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
Tint_0066	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
Tint_0067	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
Tint_0068	COG2205	protein histidine kinase activity
Tint_0069	COG0745	RESPONSE REGULATOR receiver
Tint_0071	COG0629	single-stranded DNA binding
Tint_0072	COG2814	Major facilitator Superfamily
Tint_0076	COG0739	heme binding
Tint_0077	COG0739	heme binding
Tint_0078	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
Tint_0080	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
Tint_0081	COG1862	Preprotein translocase
Tint_0082	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
Tint_0083	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
Tint_0085	COG2922	Belongs to the Smg family
Tint_0086	COG0758	DNA mediated transformation
Tint_0088	COG0242	peptide deformylase activity
Tint_0089	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
Tint_0090	COG0501	Belongs to the peptidase M48B family
Tint_0091	COG1950	PFAM Membrane protein of
Tint_0093	COG0625	glutathione transferase activity
Tint_0095	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
Tint_0097	COG0280	phosphate acetyltransferase
Tint_0097	COG0281	malic enzyme
Tint_0100	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
Tint_0101	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
Tint_0102	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
Tint_0103	COG3178	'Phosphotransferase
Tint_0105	COG0006	proline dipeptidase activity
Tint_0108	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
Tint_0110	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
Tint_0111	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
Tint_0115	COG1850	ribulose-bisphosphate carboxylase activity
Tint_0124	COG2193	ferroxidase activity
Tint_0126	COG1192	Involved in chromosome partitioning
Tint_0133	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
Tint_0134	COG1385	rRNA (uridine-N3-)-methyltransferase activity
Tint_0135	COG0583	DNA-binding transcription factor activity
Tint_0136	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
Tint_0137	COG3954	Phosphoribulokinase
Tint_0138	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
Tint_0139	COG0546	phosphoglycolate phosphatase activity
Tint_0140	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
Tint_0141	COG0126	phosphoglycerate kinase activity
Tint_0144	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
Tint_0146	COG1466	dna polymerase III delta subunit
Tint_0148	COG0495	leucyl-tRNA aminoacylation
Tint_0149	COG1252	NADH dehydrogenase
Tint_0151	COG1228	amidohydrolase
Tint_0154	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
Tint_0156	COG0154	amidase activity
Tint_0157	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
Tint_0158	COG1077	Cell shape determining protein MreB Mrl
Tint_0159	COG1792	Involved in formation and maintenance of cell shape
Tint_0161	COG0768	penicillin binding
Tint_0162	COG0772	Belongs to the SEDS family
Tint_0168	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
Tint_0169	COG0010	Belongs to the arginase family
Tint_0170	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
Tint_0175	COG0410	ABC transporter
Tint_0177	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
Tint_0178	COG0174	glutamine synthetase
Tint_0180	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
Tint_0181	COG3842	ATPase activity
Tint_0182	COG1176	ABC-type spermidine putrescine transport system, permease component I
Tint_0183	COG1177	transmembrane transport
Tint_0186	COG1012	belongs to the aldehyde dehydrogenase family
Tint_0187	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
Tint_0188	COG0300	oxidoreductase activity
Tint_0190	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
Tint_0195	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
Tint_0195	COG2755	lipolytic protein G-D-S-L family
Tint_0198	COG2813	Specifically methylates the guanine in position
Tint_0198	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
Tint_0199	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
Tint_0200	COG1120	ATPase activity
Tint_0209	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
Tint_0218	COG1278	Cold shock
Tint_0220	COG2255	four-way junction helicase activity
Tint_0227	COG1289	transmembrane transporter activity
Tint_0229	COG2814	Major facilitator Superfamily
Tint_0231	COG1566	PFAM secretion protein HlyD family protein
Tint_0232	COG1538	Outer membrane efflux protein
Tint_0237	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
Tint_0238	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
Tint_0239	COG1294	oxidase, subunit
Tint_0240	COG1271	oxidase subunit
Tint_0243	COG1846	Transcriptional regulator
Tint_0244	COG3038	cytochrome b561
Tint_0248	COG1960	acyl-CoA dehydrogenase activity
Tint_0251	COG3706	GGDEF domain
Tint_0252	COG0443	Heat shock 70 kDa protein
Tint_0253	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
Tint_0256	COG1216	Glycosyl transferase, family 2
Tint_0256	COG0463	Glycosyl transferase, family 2
Tint_0257	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
Tint_0262	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
Tint_0263	COG0343	queuine tRNA-ribosyltransferase activity
Tint_0267	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
Tint_0278	COG3258	Cytochrome c
Tint_0281	COG1872	DUF167
Tint_0283	COG0651	ATP synthesis coupled electron transport
Tint_0284	COG0650	Formate hydrogenlyase subunit 4
Tint_0286	COG0651	ATP synthesis coupled electron transport
Tint_0287	COG0649	NAD binding
Tint_0288	COG3260	NADH ubiquinone oxidoreductase 20
Tint_0297	COG1686	Belongs to the peptidase S11 family
Tint_0298	COG0675	Transposase, IS605 OrfB family
Tint_0300	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
Tint_0302	COG1024	Enoyl-CoA hydratase
Tint_0304	COG0675	Transposase, IS605 OrfB family
Tint_0305	COG2200	EAL domain
Tint_0305	COG2199	diguanylate cyclase activity
Tint_0307	COG0675	Transposase, IS605 OrfB family
Tint_0309	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
Tint_0316	COG0529	Catalyzes the synthesis of activated sulfate
Tint_0316	COG2895	sulfate adenylyltransferase (ATP) activity
Tint_0317	COG0175	sulfate reduction
Tint_0318	COG1181	Belongs to the D-alanine--D-alanine ligase family
Tint_0320	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
Tint_0324	COG1215	transferase activity, transferring glycosyl groups
Tint_0328	COG0513	Belongs to the DEAD box helicase family
Tint_0330	COG0675	Transposase, IS605 OrfB family
Tint_0331	COG2002	toxin-antitoxin pair type II binding
Tint_0332	COG0488	(ABC) transporter
Tint_0334	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
Tint_0335	COG1254	Belongs to the acylphosphatase family
Tint_0341	COG1194	a g-specific adenine glycosylase
Tint_0342	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
Tint_0343	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
Tint_0346	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
Tint_0347	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
Tint_0348	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
Tint_0349	COG1607	acyl-coa hydrolase
Tint_0350	COG5265	(ABC) transporter
Tint_0351	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
Tint_0352	COG0765	amino acid transport
Tint_0353	COG0765	amino acid transport
Tint_0354	COG1126	abc transporter atp-binding protein
Tint_0357	COG2001	Belongs to the MraZ family
Tint_0358	COG0275	rRNA processing
Tint_0361	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
Tint_0362	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
Tint_0363	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
Tint_0364	COG0772	Belongs to the SEDS family
Tint_0365	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
Tint_0366	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
Tint_0367	COG1181	Belongs to the D-alanine--D-alanine ligase family
Tint_0368	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
Tint_0370	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
Tint_0371	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
Tint_0373	COG0653	protein targeting
Tint_0376	COG0494	nUDIX hydrolase
Tint_0377	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
Tint_0378	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
Tint_0379	COG0237	dephospho-CoA kinase activity
Tint_0383	COG0582	viral genome integration into host DNA
Tint_0401	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
Tint_0402	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
Tint_0406	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
Tint_0407	COG0670	Belongs to the BI1 family
Tint_0418	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
Tint_0420	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
Tint_0423	COG0215	cysteine-tRNA ligase activity
Tint_0425	COG0825	malonyl-CoA metabolic process
Tint_0426	COG0037	tRNA processing
Tint_0431	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
Tint_0432	COG1131	(ABC) transporter
Tint_0433	COG1131	(ABC) transporter
Tint_0434	COG0842	Transport permease protein
Tint_0435	COG0842	Transport permease protein
Tint_0437	COG0574	Belongs to the PEP-utilizing enzyme family
Tint_0437	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
Tint_0439	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
Tint_0441	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
Tint_0442	COG0508	dehydrogenase complex catalyzes the overall conversion of
Tint_0442	COG0022	dehydrogenase e1 component
Tint_0443	COG0508	dehydrogenase complex catalyzes the overall conversion of
Tint_0448	COG0148	phosphopyruvate hydratase activity
Tint_0455	COG3245	cytochrome
Tint_0461	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
Tint_0465	COG0187	DNA topoisomerase II activity
Tint_0468	COG0745	RESPONSE REGULATOR receiver
Tint_0468	COG3706	GGDEF domain
Tint_0471	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
Tint_0472	COG2823	Periplasmic or secreted lipoprotein
Tint_0473	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
Tint_0474	COG2084	Dehydrogenase
Tint_0480	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
Tint_0485	COG1322	Protein conserved in bacteria
Tint_0487	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
Tint_0489	COG0850	regulation of cytokinetic process
Tint_0490	COG1136	(ABC) transporter
Tint_0492	COG0659	secondary active sulfate transmembrane transporter activity
Tint_0493	COG1086	Polysaccharide biosynthesis protein
Tint_0494	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
Tint_0496	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
Tint_0510	COG0142	geranyltranstransferase activity
Tint_0511	COG0261	This protein binds to 23S rRNA in the presence of protein L20
Tint_0512	COG0211	Belongs to the bacterial ribosomal protein bL27 family
Tint_0513	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
Tint_0514	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
Tint_0516	COG0494	nUDIX hydrolase
Tint_0517	COG0442	prolyl-tRNA aminoacylation
Tint_0518	COG0741	lytic transglycosylase activity
Tint_0519	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
Tint_0524	COG3023	N-Acetylmuramoyl-L-alanine amidase
Tint_0525	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
Tint_0525	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
Tint_0530	COG3275	phosphorelay sensor kinase activity
Tint_0532	COG1968	undecaprenyl-diphosphatase activity
Tint_0537	COG1573	uracil-dna glycosylase
Tint_0543	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
Tint_0545	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
Tint_0546	COG3300	MHYT domain
Tint_0546	COG5001	Diguanylate cyclase
Tint_0547	COG5001	Diguanylate cyclase
Tint_0547	COG3300	MHYT domain
Tint_0549	COG0477	Major facilitator Superfamily
Tint_0550	COG4681	YaeQ
Tint_0551	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
Tint_0552	COG2814	Major facilitator Superfamily
Tint_0554	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
Tint_0555	COG1522	sequence-specific DNA binding
Tint_0556	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
Tint_0561	COG4689	acetoacetate decarboxylase
Tint_0563	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
Tint_0564	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
Tint_0577	COG1473	amidohydrolase
Tint_0578	COG4636	protein conserved in cyanobacteria
Tint_0580	COG2852	Protein conserved in bacteria
Tint_0593	COG4178	(ABC) transporter
Tint_0594	COG3945	hemerythrin HHE cation binding domain
Tint_0597	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
Tint_0599	COG0668	transmembrane transport
Tint_0600	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
Tint_0601	COG5001	Diguanylate cyclase
Tint_0601	COG3300	MHYT domain
Tint_0604	COG0247	lactate metabolic process
Tint_0605	COG0277	FAD linked oxidase domain protein
Tint_0606	COG0277	FAD linked oxidase domain protein
Tint_0608	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
Tint_0612	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
Tint_0613	COG0583	DNA-binding transcription factor activity
Tint_0614	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
Tint_0615	COG3002	Belongs to the UPF0753 family
Tint_0616	COG0406	alpha-ribazole phosphatase activity
Tint_0616	COG0328	RNA-DNA hybrid ribonuclease activity
Tint_0617	COG2329	Antibiotic biosynthesis monooxygenase
Tint_0618	COG4221	oxidoreductase activity
Tint_0620	COG1538	Outer membrane efflux protein
Tint_0621	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
Tint_0624	COG2096	Adenosyltransferase
Tint_0626	COG0277	FAD linked oxidase domain protein
Tint_0630	COG4636	protein conserved in cyanobacteria
Tint_0638	COG2165	general secretion pathway protein
Tint_0644	COG4969	Belongs to the N-Me-Phe pilin family
Tint_0645	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
Tint_0646	COG0459	protein refolding
Tint_0651	COG1752	Esterase of the alpha-beta hydrolase superfamily
Tint_0652	COG0218	Necessary for normal cell division and for the maintenance of normal septation
Tint_0654	COG1333	cytochrome c biogenesis protein
Tint_0655	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
Tint_0656	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
Tint_0657	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
Tint_0659	COG1965	Belongs to the frataxin family
Tint_0667	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
Tint_0668	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
Tint_0669	COG0232	Belongs to the dGTPase family. Type 2 subfamily
Tint_0674	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
Tint_0677	COG1028	Short-chain dehydrogenase reductase Sdr
Tint_0678	COG0642	Histidine kinase
Tint_0679	COG0745	RESPONSE REGULATOR receiver
Tint_0684	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
Tint_0685	COG1262	PFAM Formylglycine-generating sulfatase enzyme
Tint_0687	COG0625	glutathione transferase activity
Tint_0689	COG1024	Enoyl-CoA hydratase
Tint_0691	COG0513	Belongs to the DEAD box helicase family
Tint_0697	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
Tint_0699	COG1944	ATP diphosphatase activity
Tint_0700	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
Tint_0714	COG0259	pyridoxamine-phosphate oxidase activity
Tint_0719	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
Tint_0721	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
Tint_0722	COG0741	lytic transglycosylase activity
Tint_0723	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
Tint_0728	COG1280	lysine exporter protein (LysE YggA)
Tint_0734	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
Tint_0735	COG0793	Belongs to the peptidase S41A family
Tint_0736	COG0588	phosphoglycerate mutase activity
Tint_0737	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
Tint_0738	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
Tint_0739	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
Tint_0740	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
Tint_0741	COG0193	aminoacyl-tRNA hydrolase activity
Tint_0743	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
Tint_0744	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
Tint_0745	COG0742	ribosomal rna small subunit methyltransferase
Tint_0750	COG2814	Major facilitator Superfamily
Tint_0752	COG0714	Associated with various cellular activities
Tint_0759	COG2921	Belongs to the UPF0250 family
Tint_0760	COG2900	Belongs to the SlyX family
Tint_0764	COG2132	Multicopper oxidase
Tint_0767	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
Tint_0770	COG0714	Associated with various cellular activities
Tint_0771	COG0123	including yeast histone deacetylase and acetoin utilization protein
Tint_0776	COG0411	ABC transporter
Tint_0777	COG1012	belongs to the aldehyde dehydrogenase family
Tint_0779	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
Tint_0780	COG0756	dUTP diphosphatase activity
Tint_0782	COG1047	Peptidyl-prolyl cis-trans
Tint_0783	COG2850	peptidyl-arginine hydroxylation
Tint_0785	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
Tint_0786	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
Tint_0788	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
Tint_0789	COG0783	Belongs to the Dps family
Tint_0790	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
Tint_0791	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
Tint_0792	COG0693	protein deglycase activity
Tint_0793	COG3118	belongs to the thioredoxin family
Tint_0794	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
Tint_0795	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
Tint_0796	COG0009	L-threonylcarbamoyladenylate synthase
Tint_0799	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
Tint_0800	COG2137	regulation of response to DNA damage stimulus
Tint_0802	COG0045	succinate-CoA ligase (ADP-forming) activity
Tint_0803	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
Tint_0804	COG0861	Integral membrane protein TerC family
Tint_0805	COG0631	protein serine/threonine phosphatase activity
Tint_0807	COG0469	pyruvate kinase activity
Tint_0811	COG3307	-O-antigen
Tint_0812	COG4783	chaperone-mediated protein folding
Tint_0813	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
Tint_0820	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
Tint_0821	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
Tint_0823	COG0745	RESPONSE REGULATOR receiver
Tint_0825	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
Tint_0830	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
Tint_0834	COG1937	Protein conserved in bacteria
Tint_0835	COG0482	sulfurtransferase activity
Tint_0836	COG1051	belongs to the nudix hydrolase family
Tint_0837	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
Tint_0838	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
Tint_0847	COG0559	Belongs to the binding-protein-dependent transport system permease family
Tint_0851	COG1127	ABC transporter
Tint_0852	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
Tint_0853	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
Tint_0854	COG2853	Lipoprotein
Tint_0857	COG1131	(ABC) transporter
Tint_0858	COG0842	Transport permease protein
Tint_0860	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
Tint_0861	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
Tint_0863	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
Tint_0864	COG0131	Imidazoleglycerol-phosphate dehydratase
Tint_0866	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
Tint_0867	COG0107	imidazoleglycerol-phosphate synthase activity
Tint_0868	COG0140	phosphoribosyl-ATP diphosphatase activity
Tint_0868	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
Tint_0870	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
Tint_0871	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
Tint_0872	COG0805	protein transport
Tint_0873	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
Tint_0874	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
Tint_0875	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
Tint_0876	COG0489	protein tyrosine kinase activity
Tint_0878	COG1105	Belongs to the carbohydrate kinase PfkB family
Tint_0879	COG0151	Belongs to the GarS family
Tint_0880	COG0217	transcriptional regulatory protein
Tint_0881	COG0433	COG0433 Predicted ATPase
Tint_0883	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
Tint_0887	COG2223	nitrite transmembrane transporter activity
Tint_0888	COG1272	protein, Hemolysin III
Tint_0894	COG0778	Nitroreductase
Tint_0898	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
Tint_0899	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
Tint_0900	COG2867	negative regulation of translational initiation
Tint_0901	COG2914	Belongs to the UPF0125 (RnfH) family
Tint_0905	COG0559	Belongs to the binding-protein-dependent transport system permease family
Tint_0906	COG0683	leucine binding
Tint_0908	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
Tint_0909	COG0415	Belongs to the DNA photolyase family
Tint_0911	COG3046	protein related to deoxyribodipyrimidine photolyase
Tint_0913	COG1028	Short-chain dehydrogenase reductase Sdr
Tint_0915	COG3706	GGDEF domain
Tint_0919	COG0559	Belongs to the binding-protein-dependent transport system permease family
Tint_0922	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
Tint_0923	COG2233	PERMEase
Tint_0925	COG0303	'Molybdopterin
Tint_0926	COG0746	molybdenum cofactor guanylyltransferase activity
Tint_0929	COG0728	peptidoglycan biosynthetic process
Tint_0930	COG0268	Binds directly to 16S ribosomal RNA
Tint_0932	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
Tint_0936	COG1162	GTPase activity
Tint_0937	COG2154	pterin-4-alpha-carbinolamine dehydratase
Tint_0938	COG0501	Belongs to the peptidase M48B family
Tint_0939	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
Tint_0942	COG2226	methyltransferase
Tint_0943	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
Tint_0944	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
Tint_0948	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
Tint_0950	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
Tint_0951	COG1914	H( )-stimulated, divalent metal cation uptake system
Tint_0953	COG1968	undecaprenyl-diphosphatase activity
Tint_0961	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
Tint_0963	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
Tint_0964	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
Tint_0967	COG0004	ammonium transporteR
Tint_0978	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
Tint_0979	COG0848	biopolymer transport protein
Tint_0980	COG0811	peptide transport
Tint_0985	COG0859	PFAM glycosyl transferase family 9
Tint_0988	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
Tint_0988	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
Tint_0989	COG1289	transmembrane transporter activity
Tint_0990	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
Tint_0994	COG1045	serine acetyltransferase
Tint_0995	COG0840	transmembrane signaling receptor activity
Tint_0998	COG1522	sequence-specific DNA binding
Tint_0999	COG3483	tryptophan 2,3-dioxygenase activity
Tint_1001	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
Tint_1003	COG3186	Phenylalanine-4-hydroxylase
Tint_1004	COG0625	glutathione transferase activity
Tint_1016	COG0084	hydrolase, TatD family'
Tint_1017	COG0326	Molecular chaperone. Has ATPase activity
Tint_1020	COG0335	large ribosomal subunit rRNA binding
Tint_1021	COG0336	Belongs to the RNA methyltransferase TrmD family
Tint_1022	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
Tint_1023	COG0228	four-way junction DNA binding
Tint_1026	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
Tint_1027	COG0617	tRNA 3'-terminal CCA addition
Tint_1029	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
Tint_1030	COG0628	permease
Tint_1031	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
Tint_1032	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
Tint_1034	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
Tint_1035	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
Tint_1036	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
Tint_1037	COG0477	Major facilitator Superfamily
Tint_1038	COG0516	GMP reductase activity
Tint_1039	COG0210	DNA helicase
Tint_1040	COG0492	ferredoxin-NADP+ reductase activity
Tint_1041	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
Tint_1044	COG0640	Transcriptional regulator
Tint_1046	COG2183	response to ionizing radiation
Tint_1047	COG0542	response to heat
Tint_1049	COG1999	signal sequence binding
Tint_1052	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
Tint_1054	COG0709	Synthesizes selenophosphate from selenide and ATP
Tint_1055	COG0583	DNA-binding transcription factor activity
Tint_1056	COG1959	2 iron, 2 sulfur cluster binding
Tint_1057	COG1104	cysteine desulfurase activity
Tint_1058	COG0822	iron-sulfur transferase activity
Tint_1060	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
Tint_1061	COG0443	Heat shock 70 kDa protein
Tint_1062	COG0633	Ferredoxin
Tint_1063	COG0322	excinuclease ABC activity
Tint_1065	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
Tint_1066	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
Tint_1066	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
Tint_1067	COG1643	Atp-dependent helicase
Tint_1070	COG3278	Belongs to the heme-copper respiratory oxidase family
Tint_1076	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
Tint_1084	COG4584	PFAM Integrase catalytic
Tint_1091	COG0166	Belongs to the GPI family
Tint_1092	COG0058	SHG alpha-glucan phosphorylase activity
Tint_1093	COG0297	glycogen (starch) synthase activity
Tint_1095	COG0033	Phosphoglucomutase
Tint_1096	COG1523	belongs to the glycosyl hydrolase 13 family
Tint_1099	COG0363	glucosamine-6-phosphate deaminase activity
Tint_1100	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
Tint_1101	COG2030	dehydratase
Tint_1105	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
Tint_1107	COG1573	uracil-dna glycosylase
Tint_1108	COG0322	excinuclease ABC activity
Tint_1116	COG1611	Belongs to the LOG family
Tint_1117	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
Tint_1120	COG1136	(ABC) transporter
Tint_1127	COG0745	RESPONSE REGULATOR receiver
Tint_1128	COG2205	protein histidine kinase activity
Tint_1132	COG0473	3-isopropylmalate dehydrogenase activity
Tint_1133	COG0776	regulation of translation
Tint_1134	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
Tint_1145	COG0582	viral genome integration into host DNA
Tint_1146	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
Tint_1148	COG3243	poly(R)-hydroxyalkanoic acid synthase
Tint_1154	COG1987	bacterial-type flagellum assembly
Tint_1157	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
Tint_1159	COG0455	bacterial-type flagellum organization
Tint_1161	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
Tint_1165	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
Tint_1166	COG3706	GGDEF domain
Tint_1168	COG4453	Protein conserved in bacteria
Tint_1170	COG0840	transmembrane signaling receptor activity
Tint_1171	COG0784	Response regulator, receiver
Tint_1171	COG0835	chemotaxis
Tint_1176	COG0643	Histidine kinase
Tint_1176	COG2198	Histidine kinase
Tint_1178	COG0745	RESPONSE REGULATOR receiver
Tint_1179	COG5001	Diguanylate cyclase
Tint_1183	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
Tint_1185	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
Tint_1186	COG0438	transferase activity, transferring glycosyl groups
Tint_1186	COG1216	Glycosyl transferase, family 2
Tint_1188	COG1256	bacterial-type flagellum assembly
Tint_1190	COG3951	Flagellar rod assembly protein muramidase FlgJ
Tint_1190	COG1705	Flagellar rod assembly protein muramidase FlgJ
Tint_1191	COG1706	bacterial-type flagellum-dependent cell motility
Tint_1192	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
Tint_1193	COG4786	Flagellar basal body rod
Tint_1195	COG1749	Flagellar hook protein flgE
Tint_1197	COG1558	bacterial-type flagellum-dependent cell motility
Tint_1198	COG1815	bacterial-type flagellum-dependent cell motility
Tint_1208	COG1516	flagellar protein fliS
Tint_1213	COG2204	response regulator
Tint_1214	COG1677	Flagellar hook-basal body complex protein FliE
Tint_1224	COG0840	transmembrane signaling receptor activity
Tint_1225	COG2201	protein-glutamate methylesterase activity
Tint_1226	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
Tint_1231	COG0840	transmembrane signaling receptor activity
Tint_1235	COG0745	RESPONSE REGULATOR receiver
Tint_1236	COG0840	transmembrane signaling receptor activity
Tint_1238	COG2197	response regulator
Tint_1241	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
Tint_1242	COG0586	Pfam SNARE associated Golgi protein
Tint_1243	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
Tint_1244	COG0252	asparaginase activity
Tint_1246	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
Tint_1253	COG0667	Aldo Keto reductase
Tint_1255	COG0655	NAD(P)H dehydrogenase (quinone) activity
Tint_1258	COG0583	DNA-binding transcription factor activity
Tint_1263	COG2022	thiamine diphosphate biosynthetic process
Tint_1267	COG2203	Gaf domain
Tint_1267	COG5001	Diguanylate cyclase
Tint_1267	COG3706	GGDEF domain
Tint_1267	COG4251	negative regulation of phosphorylation
Tint_1272	COG2132	Multicopper oxidase
Tint_1274	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
Tint_1283	COG0318	PFAM AMP-dependent synthetase and ligase
Tint_1286	COG4166	transmembrane transport
Tint_1287	COG4174	ABC transporter (Permease)
Tint_1288	COG4239	(ABC) transporter, permease
Tint_1289	COG4172	Belongs to the ABC transporter superfamily
Tint_1290	COG0779	Required for maturation of 30S ribosomal subunits
Tint_1291	COG0195	Participates in both transcription termination and antitermination
Tint_1291	COG2251	uridine kinase activity
Tint_1292	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
Tint_1293	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
Tint_1294	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
Tint_1299	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
Tint_1301	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
Tint_1302	COG1902	pentaerythritol trinitrate reductase activity
Tint_1304	COG0243	molybdopterin cofactor binding
Tint_1305	COG0437	4 iron, 4 sulfur cluster binding
Tint_1306	COG3302	dmso reductase anchor subunit
Tint_1310	COG1199	ATP-dependent helicase activity
Tint_1312	COG0564	pseudouridine synthase activity
Tint_1313	COG0463	Glycosyl transferase, family 2
Tint_1315	COG3243	poly(R)-hydroxyalkanoic acid synthase
Tint_1316	COG0183	Belongs to the thiolase family
Tint_1317	COG1028	Short-chain dehydrogenase reductase Sdr
Tint_1319	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
Tint_1321	COG0730	response to heat
Tint_1322	COG1584	GPR1 FUN34 yaaH family protein
Tint_1326	COG0708	Exodeoxyribonuclease III
Tint_1327	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
Tint_1328	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
Tint_1329	COG0196	riboflavin kinase activity
Tint_1330	COG1278	Cold shock
Tint_1331	COG0586	Pfam SNARE associated Golgi protein
Tint_1332	COG0180	Tryptophanyl-tRNA synthetase
Tint_1333	COG1994	Peptidase M50
Tint_1334	COG0009	L-threonylcarbamoyladenylate synthase
Tint_1335	COG0613	PHP domain protein
Tint_1337	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
Tint_1339	COG1666	GTP binding
Tint_1340	COG0812	UDP-N-acetylmuramate dehydrogenase activity
Tint_1342	COG0242	peptide deformylase activity
Tint_1344	COG0567	Dehydrogenase, E1 component
Tint_1345	COG0508	dehydrogenase complex catalyzes the overall conversion of
Tint_1346	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
Tint_1347	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
Tint_1349	COG0668	transmembrane transport
Tint_1350	COG0318	PFAM AMP-dependent synthetase and ligase
Tint_1353	COG1960	acyl-CoA dehydrogenase activity
Tint_1356	COG1295	ribonuclease BN
Tint_1359	COG0277	FAD linked oxidase domain protein
Tint_1360	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
Tint_1361	COG0582	viral genome integration into host DNA
Tint_1363	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
Tint_1365	COG2205	protein histidine kinase activity
Tint_1366	COG0745	RESPONSE REGULATOR receiver
Tint_1369	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
Tint_1370	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
Tint_1371	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
Tint_1373	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
Tint_1374	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
Tint_1375	COG0072	phenylalanine-tRNA ligase activity
Tint_1375	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
Tint_1376	COG0776	regulation of translation
Tint_1378	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
Tint_1379	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
Tint_1379	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
Tint_1382	COG2224	Isocitrate lyase
Tint_1384	COG0477	Major facilitator Superfamily
Tint_1387	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
Tint_1388	COG0133	tryptophan synthase activity
Tint_1389	COG1132	(ABC) transporter
Tint_1391	COG0739	heme binding
Tint_1392	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
Tint_1394	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
Tint_1395	COG0542	response to heat
Tint_1412	COG1477	protein flavinylation
Tint_1414	COG2890	protein-(glutamine-N5) methyltransferase activity
Tint_1415	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
Tint_1417	COG0318	PFAM AMP-dependent synthetase and ligase
Tint_1421	COG3852	Histidine kinase
Tint_1425	COG1120	ATPase activity
Tint_1426	COG1108	ABC-type Mn2 Zn2 transport systems permease components
Tint_1427	COG0129	dihydroxy-acid dehydratase activity
Tint_1428	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
Tint_1434	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
Tint_1435	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
Tint_1436	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
Tint_1437	COG0271	Belongs to the BolA IbaG family
Tint_1438	COG2917	probably involved in intracellular septation
Tint_1439	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
Tint_1446	COG2943	transferase activity, transferring hexosyl groups
Tint_1447	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
Tint_1451	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
Tint_1452	COG0024	Methionine aminopeptidase
Tint_1453	COG0047	phosphoribosylformylglycinamidine synthase activity
Tint_1453	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
Tint_1457	COG1959	2 iron, 2 sulfur cluster binding
Tint_1460	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
Tint_1461	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
Tint_1462	COG1999	signal sequence binding
Tint_1470	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
Tint_1471	COG1522	sequence-specific DNA binding
Tint_1472	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
Tint_1474	COG1804	L-carnitine dehydratase bile acid-inducible protein F
Tint_1477	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
Tint_1478	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
Tint_1481	COG0084	hydrolase, TatD family'
Tint_1483	COG1982	Orn Lys Arg decarboxylase major
Tint_1485	COG0330	HflC and HflK could
Tint_1486	COG2833	Protein of unknown function (DUF455)
Tint_1490	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
Tint_1491	COG2095	MarC family integral membrane protein
Tint_1492	COG4974	Belongs to the 'phage' integrase family
Tint_1494	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
Tint_1495	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
Tint_1496	COG1940	carbohydrate kinase activity
Tint_1497	COG2963	transposase activity
Tint_1500	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
Tint_1502	COG1196	nuclear chromosome segregation
Tint_1503	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
Tint_1504	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
Tint_1511	COG0438	transferase activity, transferring glycosyl groups
Tint_1513	COG0438	transferase activity, transferring glycosyl groups
Tint_1514	COG1434	Gram-negative-bacterium-type cell wall biogenesis
Tint_1515	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
Tint_1516	COG0546	phosphoglycolate phosphatase activity
Tint_1520	COG4372	Transposase
Tint_1531	COG2189	Belongs to the N(4) N(6)-methyltransferase family
Tint_1534	COG3550	peptidyl-serine autophosphorylation
Tint_1538	COG0582	viral genome integration into host DNA
Tint_1545	COG1002	Type II restriction enzyme, methylase subunits
Tint_1548	COG1061	Type III restriction enzyme res subunit
Tint_1549	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
Tint_1556	COG0582	viral genome integration into host DNA
Tint_1559	COG1484	DNA-dependent DNA replication
Tint_1565	COG0410	ABC transporter
Tint_1566	COG0411	ABC transporter
Tint_1568	COG0559	Belongs to the binding-protein-dependent transport system permease family
Tint_1570	COG2015	COG2015, Alkyl sulfatase and related hydrolases
Tint_1577	COG1484	DNA-dependent DNA replication
Tint_1578	COG4584	PFAM Integrase catalytic
Tint_1583	COG0435	Glutathione S-transferase
Tint_1584	COG0523	cobalamin synthesis protein
Tint_1585	COG1228	amidohydrolase
Tint_1587	COG0318	PFAM AMP-dependent synthetase and ligase
Tint_1591	COG2130	NADP-dependent
Tint_1592	COG1028	Short-chain dehydrogenase reductase Sdr
Tint_1593	COG1960	acyl-CoA dehydrogenase activity
Tint_1594	COG0183	Belongs to the thiolase family
Tint_1596	COG2045	Belongs to the ComB family
Tint_1597	COG0596	Alpha beta hydrolase
Tint_1600	COG1960	acyl-CoA dehydrogenase activity
Tint_1603	COG1028	Short-chain dehydrogenase reductase Sdr
Tint_1610	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
Tint_1611	COG1469	GTP cyclohydrolase I activity
Tint_1612	COG1108	ABC-type Mn2 Zn2 transport systems permease components
Tint_1613	COG1121	(ABC) transporter
Tint_1615	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
Tint_1616	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
Tint_1617	COG0142	geranyltranstransferase activity
Tint_1618	COG1722	exodeoxyribonuclease VII activity
Tint_1623	COG0412	Dienelactone hydrolase
Tint_1625	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
Tint_1626	COG1741	Belongs to the pirin family
Tint_1630	COG1129	ABC transporter
Tint_1631	COG0402	S-adenosylhomocysteine deaminase activity
Tint_1632	COG2252	PERMEase
Tint_1635	COG1529	Aldehyde oxidase and xanthine dehydrogenase
Tint_1637	COG0129	dihydroxy-acid dehydratase activity
Tint_1638	COG0583	DNA-binding transcription factor activity
Tint_1640	COG2963	transposase activity
Tint_1646	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
Tint_1647	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
Tint_1649	COG2003	Belongs to the UPF0758 family
Tint_1652	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
Tint_1655	COG1850	ribulose-bisphosphate carboxylase activity
Tint_1657	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
Tint_1658	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
Tint_1659	COG0740	serine-type endopeptidase activity
Tint_1660	COG0544	peptidyl-prolyl cis-trans isomerase activity
Tint_1661	COG1562	ergosterol biosynthetic process
Tint_1662	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
Tint_1664	COG1028	Short-chain dehydrogenase reductase Sdr
Tint_1666	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
Tint_1667	COG0367	asparagine synthase
Tint_1670	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
Tint_1675	COG0563	adenylate kinase activity
Tint_1676	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
Tint_1677	COG2835	tetraacyldisaccharide 4'-kinase activity
Tint_1678	COG1663	tetraacyldisaccharide 4'-kinase activity
Tint_1680	COG0811	peptide transport
Tint_1681	COG1570	exodeoxyribonuclease VII activity
Tint_1682	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
Tint_1689	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
Tint_1689	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
Tint_1690	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
Tint_1691	COG0560	Phosphoserine phosphatase
Tint_1694	COG1253	flavin adenine dinucleotide binding
Tint_1698	COG0114	fumarate hydratase activity
Tint_1699	COG0650	Formate hydrogenlyase subunit 4
Tint_1701	COG0651	ATP synthesis coupled electron transport
Tint_1702	COG0649	NAD binding
Tint_1703	COG3260	NADH ubiquinone oxidoreductase 20
Tint_1704	COG0651	ATP synthesis coupled electron transport
Tint_1705	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
Tint_1706	COG1993	acr, cog1993
Tint_1708	COG1193	negative regulation of DNA recombination
Tint_1710	COG0148	phosphopyruvate hydratase activity
Tint_1711	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
Tint_1713	COG0406	alpha-ribazole phosphatase activity
Tint_1714	COG0248	Ppx GppA phosphatase
Tint_1715	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
Tint_1717	COG0745	RESPONSE REGULATOR receiver
Tint_1719	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
Tint_1721	COG0573	inorganic phosphate transmembrane transporter activity
Tint_1723	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
Tint_1725	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
Tint_1727	COG1534	Rna-binding protein
Tint_1729	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
Tint_1730	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
Tint_1732	COG0505	Belongs to the CarA family
Tint_1734	COG1960	acyl-CoA dehydrogenase activity
Tint_1736	COG2076	Multidrug Resistance protein
Tint_1737	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
Tint_1738	COG1215	transferase activity, transferring glycosyl groups
Tint_1740	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
Tint_1740	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
Tint_1742	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
Tint_1743	COG0254	rRNA binding
Tint_1745	COG0534	Mate efflux family protein
Tint_1748	COG2890	protein-(glutamine-N5) methyltransferase activity
Tint_1749	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
Tint_1751	COG2171	N-acyltransferase activity
Tint_1752	COG0436	Aminotransferase
Tint_1756	COG1619	proteins homologs of microcin C7 resistance protein MccF
Tint_1757	COG0590	tRNA wobble adenosine to inosine editing
Tint_1759	COG0518	GMP synthase (glutamine-hydrolyzing) activity
Tint_1759	COG0519	Catalyzes the synthesis of GMP from XMP
Tint_1763	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
Tint_1764	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
Tint_1765	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
Tint_1766	COG0330	HflC and HflK could
Tint_1767	COG0330	HflC and HflK could
Tint_1768	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
Tint_1769	COG1923	regulation of RNA biosynthetic process
Tint_1771	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
Tint_1772	COG2976	Protein conserved in bacteria
Tint_1773	COG0124	histidyl-tRNA synthetase
Tint_1774	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
Tint_1777	COG0820	rRNA (adenine-C2-)-methyltransferase activity
Tint_1778	COG0105	UTP biosynthetic process
Tint_1779	COG1187	pseudouridine synthase activity
Tint_1780	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
Tint_1782	COG0347	Belongs to the P(II) protein family
Tint_1783	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
Tint_1783	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
Tint_1785	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
Tint_1787	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
Tint_1788	COG0443	Heat shock 70 kDa protein
Tint_1789	COG0484	heat shock protein binding
Tint_1791	COG0308	aminopeptidase N
Tint_1792	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
Tint_1797	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
Tint_1798	COG0802	atpase or kinase
Tint_1799	COG0860	N-Acetylmuramoyl-L-alanine amidase
Tint_1800	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
Tint_1801	COG0726	polysaccharide deacetylase
Tint_1804	COG0425	Belongs to the sulfur carrier protein TusA family
Tint_1810	COG0842	Transport permease protein
Tint_1811	COG0842	Transport permease protein
Tint_1812	COG1131	(ABC) transporter
Tint_1815	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
Tint_1819	COG0477	Major facilitator Superfamily
Tint_1820	COG2326	polyphosphate kinase activity
Tint_1826	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
Tint_1827	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
Tint_1830	COG3706	GGDEF domain
Tint_1836	COG0181	hydroxymethylbilane synthase activity
Tint_1837	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
Tint_1838	COG1752	Esterase of the alpha-beta hydrolase superfamily
Tint_1840	COG0671	phosphoesterase, PA-phosphatase related
Tint_1843	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
Tint_1844	COG0745	RESPONSE REGULATOR receiver
Tint_1847	COG2133	pyrroloquinoline quinone binding
Tint_1851	COG2878	Part of a membrane complex involved in electron transport
Tint_1852	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
Tint_1855	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
Tint_1856	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
Tint_1862	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
Tint_1864	COG0525	valine-tRNA ligase activity
Tint_1865	COG0776	regulation of translation
Tint_1867	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
Tint_1868	COG0287	Prephenate dehydrogenase
Tint_1869	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
Tint_1871	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
Tint_1876	COG0557	exoribonuclease II activity
Tint_1879	COG2963	transposase activity
Tint_1887	COG2135	peptidase activity
Tint_1889	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
Tint_1890	COG0587	DNA-directed DNA polymerase activity
Tint_1895	COG2442	InterPro IPR007367
Tint_1896	COG4634	DNA integration
Tint_1906	COG2119	membrane
Tint_1917	COG2963	transposase activity
Tint_1928	COG0582	viral genome integration into host DNA
Tint_1939	COG1733	regulation of RNA biosynthetic process
Tint_1943	COG0583	DNA-binding transcription factor activity
Tint_1946	COG3039	Transposase
Tint_1956	COG2814	Major facilitator Superfamily
Tint_1971	COG3451	type IV secretory pathway VirB4
Tint_1976	COG3550	peptidyl-serine autophosphorylation
Tint_1983	COG2433	Pfam Transposase IS66
Tint_1984	COG4372	Transposase
Tint_1993	COG1309	transcriptional regulator
Tint_1994	COG4962	Type ii secretion system protein e
Tint_2000	COG0583	DNA-binding transcription factor activity
Tint_2001	COG0477	Major facilitator Superfamily
Tint_2003	COG0583	DNA-binding transcription factor activity
Tint_2017	COG3177	Filamentation induced by cAMP protein fic
Tint_2018	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
Tint_2020	COG0287	Prephenate dehydrogenase
Tint_2020	COG1605	Chorismate mutase
Tint_2026	COG4197	protein conserved in bacteria, prophage-related
Tint_2028	COG0629	single-stranded DNA binding
Tint_2033	COG0667	Aldo Keto reductase
Tint_2034	COG0583	DNA-binding transcription factor activity
Tint_2044	COG1733	regulation of RNA biosynthetic process
Tint_2045	COG0477	Major facilitator Superfamily
Tint_2047	COG0477	Major facilitator Superfamily
Tint_2050	COG0583	DNA-binding transcription factor activity
Tint_2053	COG0583	DNA-binding transcription factor activity
Tint_2056	COG3842	ATPase activity
Tint_2059	COG0431	NADPH-dependent FMN reductase
Tint_2069	COG0582	viral genome integration into host DNA
Tint_2070	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
Tint_2074	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
Tint_2075	COG1902	pentaerythritol trinitrate reductase activity
Tint_2079	COG0446	pyridine nucleotide-disulphide oxidoreductase
Tint_2083	COG0730	response to heat
Tint_2084	COG0446	pyridine nucleotide-disulphide oxidoreductase
Tint_2092	COG3267	Type II secretory pathway component ExeA
Tint_2092	COG3409	Peptidoglycan-binding domain 1 protein
Tint_2094	COG0489	protein tyrosine kinase activity
Tint_2095	COG0318	PFAM AMP-dependent synthetase and ligase
Tint_2095	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
Tint_2095	COG0300	oxidoreductase activity
Tint_2095	COG3321	synthase
Tint_2095	COG1028	Short-chain dehydrogenase reductase Sdr
Tint_2098	COG0328	RNA-DNA hybrid ribonuclease activity
Tint_2099	COG2226	methyltransferase
Tint_2101	COG1388	LysM domain
Tint_2101	COG0741	lytic transglycosylase activity
Tint_2102	COG1804	L-carnitine dehydratase bile acid-inducible protein F
Tint_2107	COG0314	molybdopterin synthase activity
Tint_2109	COG0303	'Molybdopterin
Tint_2110	COG1763	Mo-molybdopterin cofactor biosynthetic process
Tint_2113	COG0436	Aminotransferase
Tint_2115	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
Tint_2116	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
Tint_2117	COG0305	Participates in initiation and elongation during chromosome replication
Tint_2118	COG0359	binds to the 23S rRNA
Tint_2119	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
Tint_2123	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
Tint_2125	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
Tint_2126	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
Tint_2127	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
Tint_2128	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
Tint_2129	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
Tint_2130	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
Tint_2133	COG0750	zinc metalloprotease
Tint_2134	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
Tint_2135	COG0575	Belongs to the CDS family
Tint_2139	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
Tint_2140	COG0052	Belongs to the universal ribosomal protein uS2 family
Tint_2142	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
Tint_2143	COG4181	ATPase activity
Tint_2145	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
Tint_2146	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
Tint_2149	COG1045	serine acetyltransferase
Tint_2150	COG1183	phosphatidylcholine synthase activity
Tint_2151	COG0688	phosphatidylethanolamine metabolic process
Tint_2152	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
Tint_2153	COG0440	acetolactate synthase activity
Tint_2154	COG0028	Belongs to the TPP enzyme family
Tint_2162	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
Tint_2163	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
Tint_2164	COG0312	modulator of DNA gyrase
Tint_2165	COG3028	Belongs to the UPF0307 family
Tint_2166	COG0521	Mo-molybdopterin cofactor biosynthetic process
Tint_2167	COG0725	ABC transporter, periplasmic molybdate-binding protein
Tint_2169	COG3842	ATPase activity
Tint_2170	COG0745	RESPONSE REGULATOR receiver
Tint_2170	COG3706	GGDEF domain
Tint_2171	COG0667	Aldo Keto reductase
Tint_2172	COG5002	protein histidine kinase activity
Tint_2172	COG5001	Diguanylate cyclase
Tint_2172	COG3447	MASE1 domain protein
Tint_2173	COG1609	Transcriptional regulator
Tint_2174	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
Tint_2174	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
Tint_2175	COG1105	Belongs to the carbohydrate kinase PfkB family
Tint_2176	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
Tint_2176	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
Tint_2178	COG0531	amino acid
Tint_2181	COG0514	ATP-dependent DNA helicase (RecQ)
Tint_2184	COG0670	Belongs to the BI1 family
Tint_2185	COG0583	DNA-binding transcription factor activity
Tint_2187	COG1703	isobutyryl-CoA mutase activity
Tint_2187	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
Tint_2187	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
Tint_2189	COG1187	pseudouridine synthase activity
Tint_2190	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
Tint_2192	COG0723	plastoquinol--plastocyanin reductase activity
Tint_2193	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
Tint_2194	COG2857	Cytochrome c1
Tint_2195	COG0625	glutathione transferase activity
Tint_2196	COG2969	positive regulation of protein catabolic process
Tint_2211	COG2226	methyltransferase
Tint_2214	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
Tint_2215	COG0656	L-ascorbic acid biosynthetic process
Tint_2217	COG2814	Major facilitator Superfamily
Tint_2218	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
Tint_2219	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
Tint_2220	COG1280	lysine exporter protein (LysE YggA)
Tint_2223	COG0137	argininosuccinate synthase activity
Tint_2224	COG3123	guanosine phosphorylase activity
Tint_2226	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
Tint_2229	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
Tint_2231	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
Tint_2233	COG0523	cobalamin synthesis protein
Tint_2234	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
Tint_2236	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
Tint_2238	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
Tint_2241	COG2186	Transcriptional regulator
Tint_2244	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
Tint_2246	COG0700	Nucleoside recognition
Tint_2252	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
Tint_2253	COG0494	nUDIX hydrolase
Tint_2255	COG1007	ATP synthesis coupled electron transport
Tint_2261	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
Tint_2262	COG1034	ATP synthesis coupled electron transport
Tint_2265	COG0649	NAD binding
Tint_2266	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
Tint_2268	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
Tint_2269	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
Tint_2270	COG0149	triose-phosphate isomerase activity
Tint_2271	COG1063	alcohol dehydrogenase
Tint_2272	COG1185	polyribonucleotide nucleotidyltransferase activity
Tint_2274	COG0071	Belongs to the small heat shock protein (HSP20) family
Tint_2276	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
Tint_2277	COG2081	HI0933 family
Tint_2278	COG0828	Belongs to the bacterial ribosomal protein bS21 family
Tint_2280	COG2267	carboxylic ester hydrolase activity
Tint_2281	COG0504	CTP synthase activity
Tint_2282	COG2877	3-deoxy-8-phosphooctulonate synthase activity
Tint_2284	COG0148	phosphopyruvate hydratase activity
Tint_2285	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
Tint_2286	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
Tint_2288	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
Tint_2289	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
Tint_2290	COG1139	Iron-sulfur cluster binding protein
Tint_2293	COG1686	Belongs to the peptidase S11 family
Tint_2299	COG4654	Cytochrome c, class I
Tint_2303	COG0604	alcohol dehydrogenase
Tint_2304	COG0791	NLP P60 protein
Tint_2305	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
Tint_2306	COG0508	dehydrogenase complex catalyzes the overall conversion of
Tint_2307	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
Tint_2309	COG4566	intracellular signal transduction
Tint_2310	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
Tint_2311	COG0339	signal peptide processing
Tint_2314	COG0167	dihydroorotate dehydrogenase activity
Tint_2316	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
Tint_2319	COG1286	toxin biosynthetic process
Tint_2321	COG0285	dihydrofolate synthase activity
Tint_2322	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
Tint_2323	COG0159	tryptophan synthase activity
Tint_2324	COG0133	tryptophan synthase activity
Tint_2325	COG0135	phosphoribosylanthranilate isomerase activity
Tint_2328	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
Tint_2329	COG0473	3-isopropylmalate dehydrogenase activity
Tint_2330	COG0066	3-isopropylmalate dehydratase activity
Tint_2332	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
Tint_2333	COG2226	methyltransferase
Tint_2335	COG0372	Belongs to the citrate synthase family
Tint_2336	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
Tint_2337	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
Tint_2338	COG1053	succinate dehydrogenase
Tint_2339	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
Tint_2341	COG2188	Transcriptional regulator
Tint_2342	COG0039	L-malate dehydrogenase activity
Tint_2347	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
Tint_2348	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
Tint_2349	COG1393	Belongs to the ArsC family
Tint_2350	COG3022	response to hydroperoxide
Tint_2351	COG3634	alkyl hydroperoxide reductase activity
Tint_2352	COG0450	alkyl hydroperoxide reductase
Tint_2353	COG2084	Dehydrogenase
Tint_2355	COG0408	coproporphyrinogen oxidase activity
Tint_2356	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
Tint_2357	COG0799	negative regulation of ribosome biogenesis
Tint_2359	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
Tint_2360	COG0352	thiamine-phosphate diphosphorylase activity
Tint_2361	COG0351	phosphomethylpyrimidine kinase
Tint_2369	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
Tint_2370	COG0511	ligase activity, forming carbon-carbon bonds
Tint_2371	COG0439	Biotin carboxylase
Tint_2372	COG2264	protein methyltransferase activity
Tint_2374	COG1472	Belongs to the glycosyl hydrolase 3 family
Tint_2375	COG0736	holo-[acyl-carrier-protein] synthase activity
Tint_2377	COG1381	Involved in DNA repair and RecF pathway recombination
Tint_2378	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
Tint_2379	COG0571	ribonuclease III activity
Tint_2382	COG0481	GTPase activity
Tint_2383	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
Tint_2388	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
Tint_2389	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
Tint_2390	COG1028	Short-chain dehydrogenase reductase Sdr
Tint_2391	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
Tint_2392	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
Tint_2393	COG0416	fatty acid biosynthetic process
Tint_2394	COG0333	Belongs to the bacterial ribosomal protein bL32 family
Tint_2395	COG1399	metal-binding, possibly nucleic acid-binding protein
Tint_2397	COG2391	methyltransferase activity
Tint_2398	COG0424	maF-like protein
Tint_2399	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
Tint_2399	COG0616	signal peptide processing
Tint_2405	COG0564	pseudouridine synthase activity
Tint_2406	COG1530	ribonuclease E activity
Tint_2407	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
Tint_2408	COG0543	2 iron, 2 sulfur cluster binding
Tint_2408	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
Tint_2413	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
Tint_2414	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
Tint_2415	COG1674	ftsk spoiiie
Tint_2417	COG0492	ferredoxin-NADP+ reductase activity
Tint_2418	COG0227	Belongs to the bacterial ribosomal protein bL28 family
Tint_2419	COG0267	Belongs to the bacterial ribosomal protein bL33 family
Tint_2421	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
Tint_2421	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
Tint_2422	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
Tint_2423	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
Tint_2424	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
Tint_2424	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
Tint_2429	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
Tint_2430	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
Tint_2434	COG0824	Thioesterase
Tint_2442	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
Tint_2443	COG1215	transferase activity, transferring glycosyl groups
Tint_2445	COG1132	(ABC) transporter
Tint_2449	COG0823	Involved in the tonB-independent uptake of proteins
Tint_2450	COG2885	chlorophyll binding
Tint_2452	COG2391	methyltransferase activity
Tint_2453	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
Tint_2463	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
Tint_2465	COG2151	metal-sulfur cluster biosynthetic enzyme
Tint_2467	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
Tint_2468	COG0719	Fe-S assembly protein
Tint_2469	COG0396	ATPase activity
Tint_2470	COG0719	Fe-S assembly protein
Tint_2473	COG3850	Histidine kinase
Tint_2474	COG2197	response regulator
Tint_2477	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
Tint_2478	COG1140	nitrate reductase beta subunit
Tint_2479	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
Tint_2480	COG2181	nitrate reductase activity
Tint_2487	COG1484	DNA-dependent DNA replication
Tint_2496	COG4575	ribosome binding
Tint_2498	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
Tint_2499	COG0038	chloride channel
Tint_2502	COG1469	GTP cyclohydrolase I activity
Tint_2505	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
Tint_2512	COG0473	3-isopropylmalate dehydrogenase activity
Tint_2514	COG1331	Highly conserved protein containing a thioredoxin domain
Tint_2518	COG0318	PFAM AMP-dependent synthetase and ligase
Tint_2519	COG0210	DNA helicase
Tint_2522	COG0741	lytic transglycosylase activity
Tint_2523	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
Tint_2524	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
Tint_2524	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
Tint_2528	COG2267	carboxylic ester hydrolase activity
Tint_2530	COG3150	esterase
Tint_2531	COG1028	Short-chain dehydrogenase reductase Sdr
Tint_2534	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
Tint_2535	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
Tint_2536	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
Tint_2537	COG0351	phosphomethylpyrimidine kinase
Tint_2538	COG1773	rubredoxin
Tint_2542	COG0840	transmembrane signaling receptor activity
Tint_2543	COG2198	Histidine kinase
Tint_2543	COG0643	Histidine kinase
Tint_2544	COG0415	Belongs to the DNA photolyase family
Tint_2545	COG1678	Uncharacterized ACR, COG1678
Tint_2546	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
Tint_2547	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
Tint_2548	COG0540	Belongs to the ATCase OTCase family
Tint_2553	COG1484	DNA-dependent DNA replication
Tint_2555	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
Tint_2556	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
Tint_2557	COG0424	maF-like protein
Tint_2558	COG1530	ribonuclease E activity
Tint_2562	COG2951	lytic endotransglycosylase activity
Tint_2568	COG1088	dTDP-glucose 4,6-dehydratase activity
Tint_2569	COG1760	l-serine dehydratase
Tint_2571	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
Tint_2571	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
Tint_2572	COG0509	glycine decarboxylation via glycine cleavage system
Tint_2573	COG0404	The glycine cleavage system catalyzes the degradation of glycine
Tint_2579	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
Tint_2580	COG0795	lipopolysaccharide-transporting ATPase activity
Tint_2582	COG0583	DNA-binding transcription factor activity
Tint_2583	COG0436	Aminotransferase
Tint_2584	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
Tint_2585	COG1999	signal sequence binding
Tint_2593	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
Tint_2596	COG2226	methyltransferase
Tint_2597	COG1040	competence protein
Tint_2598	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
Tint_2600	COG0183	Belongs to the thiolase family
Tint_2601	COG1024	Enoyl-CoA hydratase
Tint_2601	COG1250	3-hydroxyacyl-CoA dehydrogenase
Tint_2602	COG1960	acyl-CoA dehydrogenase activity
Tint_2604	COG0243	molybdopterin cofactor binding
Tint_2606	COG4232	protein-disulfide reductase activity
Tint_2607	COG0842	Transport permease protein
Tint_2608	COG1131	(ABC) transporter
Tint_2610	COG0202	RNA polymerase activity
Tint_2611	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
Tint_2612	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
Tint_2613	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
Tint_2614	COG0257	Belongs to the bacterial ribosomal protein bL36 family
Tint_2616	COG0201	protein transport
Tint_2617	COG0200	Binds to the 23S rRNA
Tint_2618	COG1841	ribosomal large subunit assembly
Tint_2619	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
Tint_2620	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
Tint_2621	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
Tint_2622	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
Tint_2623	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
Tint_2624	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
Tint_2625	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
Tint_2626	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
Tint_2628	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
Tint_2629	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
Tint_2630	COG2890	protein-(glutamine-N5) methyltransferase activity
Tint_2631	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
Tint_2632	COG0163	prenyltransferase activity
Tint_2633	COG2326	polyphosphate kinase activity
Tint_2640	COG1335	isochorismatase
Tint_2641	COG0247	lactate metabolic process
Tint_2642	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
Tint_2646	COG2414	aldehyde ferredoxin oxidoreductase
Tint_2647	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
Tint_2650	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
Tint_2651	COG3039	Transposase
Tint_2652	COG2089	acid synthase
Tint_2653	COG1083	cytidylyl-transferase
Tint_2654	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
Tint_2656	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
Tint_2659	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
Tint_2660	COG1074	ATP-dependent DNA helicase activity
Tint_2661	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
Tint_2663	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
Tint_2664	COG1758	RNA polymerase activity
Tint_2665	COG0194	GDP metabolic process
Tint_2666	COG1561	YicC-like family, N-terminal region
Tint_2669	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
Tint_2670	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
Tint_2671	COG0635	Involved in the biosynthesis of porphyrin-containing compound
Tint_2674	COG1116	anion transmembrane transporter activity
Tint_2676	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
Tint_2677	COG1881	PFAM PEBP family protein
Tint_2679	COG0642	Histidine kinase
Tint_2681	COG0668	transmembrane transport
Tint_2683	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
Tint_2685	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
Tint_2688	COG0284	orotidine-5'-phosphate decarboxylase activity
Tint_2689	COG0315	cyclic pyranopterin monophosphate synthase activity
Tint_2690	COG0312	modulator of DNA gyrase
Tint_2693	COG2326	polyphosphate kinase activity
Tint_2695	COG1704	LemA family
Tint_2696	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
Tint_2698	COG2982	Protein involved in outer membrane biogenesis
Tint_2699	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
Tint_2700	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
Tint_2705	COG1858	cytochrome C peroxidase
Tint_2706	COG3511	phospholipase C
Tint_2707	COG0632	four-way junction helicase activity
Tint_2708	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
Tint_2711	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
Tint_2712	COG0138	bifunctional purine biosynthesis protein purh
Tint_2713	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
Tint_2714	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
Tint_2721	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
Tint_2722	COG1024	Enoyl-CoA hydratase
Tint_2726	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
Tint_2727	COG0318	PFAM AMP-dependent synthetase and ligase
Tint_2729	COG1960	acyl-CoA dehydrogenase activity
Tint_2731	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
Tint_2733	COG1960	acyl-CoA dehydrogenase activity
Tint_2735	COG0789	Transcriptional regulator
Tint_2736	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
Tint_2738	COG0598	Magnesium transport protein CorA
Tint_2741	COG0297	glycogen (starch) synthase activity
Tint_2745	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
Tint_2747	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
Tint_2748	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
Tint_2750	COG0018	arginyl-trna synthetase
Tint_2753	COG0355	proton-transporting ATP synthase activity, rotational mechanism
Tint_2754	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
Tint_2755	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
Tint_2757	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
Tint_2758	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
Tint_2760	COG0356	it plays a direct role in the translocation of protons across the membrane
Tint_2768	COG1459	type II secretion system
Tint_2782	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
Tint_2783	COG1715	Restriction endonuclease
Tint_2784	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
Tint_2786	COG1126	abc transporter atp-binding protein
Tint_2788	COG0436	Aminotransferase
Tint_2790	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
Tint_2793	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
Tint_2794	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
Tint_2795	COG0583	DNA-binding transcription factor activity
Tint_2796	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
Tint_2797	COG3706	GGDEF domain
Tint_2797	COG0745	RESPONSE REGULATOR receiver
Tint_2798	COG4221	oxidoreductase activity
Tint_2800	COG0735	belongs to the Fur family
Tint_2802	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
Tint_2803	COG0321	lipoyl(octanoyl) transferase activity
Tint_2808	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
Tint_2809	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
Tint_2817	COG0347	Belongs to the P(II) protein family
Tint_2818	COG0004	ammonium transporteR
Tint_2824	COG0189	ligase activity
Tint_2826	COG0450	alkyl hydroperoxide reductase
Tint_2829	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
Tint_2834	COG1660	Displays ATPase and GTPase activities
Tint_2835	COG0497	DNA recombination
Tint_2836	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
Tint_2837	COG1420	regulation of RNA biosynthetic process
Tint_2840	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
Tint_2841	COG1765	OsmC-like protein
Tint_2843	COG1238	metal cluster binding
Tint_2844	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
Tint_2849	COG1028	Short-chain dehydrogenase reductase Sdr
Tint_2852	COG2814	Major facilitator Superfamily
Tint_2853	COG0583	DNA-binding transcription factor activity
Tint_2856	COG2084	Dehydrogenase
Tint_2857	COG3622	Belongs to the hyi family
Tint_2858	COG3960	tartronate-semialdehyde synthase activity
Tint_2860	COG1942	4-Oxalocrotonate Tautomerase
Tint_2861	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
Tint_2862	COG1566	PFAM secretion protein HlyD family protein
Tint_2864	COG1136	(ABC) transporter
Tint_2866	COG0012	GTP binding
Tint_2868	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
Tint_2869	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
Tint_2870	COG0255	Belongs to the universal ribosomal protein uL29 family
Tint_2871	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
Tint_2872	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
Tint_2873	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
Tint_2874	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
Tint_2875	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
Tint_2876	COG0089	rRNA binding
Tint_2877	COG0088	Forms part of the polypeptide exit tunnel
Tint_2878	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
Tint_2879	COG0051	transcription antitermination factor activity, RNA binding
Tint_2880	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
Tint_2881	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
Tint_2882	COG0049	tRNA binding
Tint_2883	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
Tint_2884	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
Tint_2885	COG2197	response regulator
Tint_2886	COG1702	phosphate starvation-inducible protein PhoH
Tint_2887	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
Tint_2888	COG0815	Transfers the fatty acyl group on membrane lipoproteins
Tint_2890	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
Tint_2891	COG2814	Major facilitator Superfamily
Tint_2892	COG3258	Cytochrome c
Tint_2893	COG2863	cytochrome
Tint_2895	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
Tint_2898	COG2863	cytochrome
Tint_2899	COG0446	pyridine nucleotide-disulphide oxidoreductase
Tint_2901	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
Tint_2901	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
Tint_2903	COG5000	phosphorelay sensor kinase activity
Tint_2904	COG2204	response regulator
Tint_2913	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
Tint_2923	COG5377	YqaJ viral recombinase family
Tint_2929	COG4983	Phage plasmid primase, P4 family domain protein
Tint_2937	COG0582	viral genome integration into host DNA
Tint_2940	COG3161	chorismate lyase activity
Tint_2942	COG0583	DNA-binding transcription factor activity
Tint_2943	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
Tint_2945	COG0725	ABC transporter, periplasmic molybdate-binding protein
Tint_2946	COG4149	molybdate abc transporter
Tint_2947	COG3842	ATPase activity
Tint_2955	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
Tint_2959	COG0437	4 iron, 4 sulfur cluster binding
Tint_2960	COG3383	formate dehydrogenase (NAD+) activity
Tint_2960	COG0243	molybdopterin cofactor binding
Tint_2963	COG2181	nitrate reductase activity
Tint_2963	COG0247	lactate metabolic process
Tint_2967	COG1970	mechanosensitive ion channel activity
Tint_2972	COG2911	Protein conserved in bacteria
Tint_2973	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
Tint_2979	COG2223	nitrite transmembrane transporter activity
Tint_2981	COG0667	Aldo Keto reductase
Tint_2983	COG1484	DNA-dependent DNA replication
Tint_2988	COG0410	ABC transporter
Tint_2989	COG0411	ABC transporter
Tint_2994	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
Tint_2997	COG1012	belongs to the aldehyde dehydrogenase family
Tint_2997	COG2030	dehydratase
Tint_2998	COG0183	Belongs to the thiolase family
Tint_2999	COG1309	transcriptional regulator
Tint_3000	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
Tint_3001	COG2151	metal-sulfur cluster biosynthetic enzyme
Tint_3002	COG3396	Phenylacetate-CoA oxygenase
Tint_3003	COG3460	Phenylacetate-CoA oxygenase
Tint_3004	COG3396	Phenylacetate-CoA oxygenase
Tint_3006	COG2050	protein possibly involved in aromatic compounds catabolism
Tint_3007	COG1250	3-hydroxyacyl-CoA dehydrogenase
Tint_3008	COG1024	Enoyl-CoA hydratase
Tint_3010	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
Tint_3015	COG4584	PFAM Integrase catalytic
Tint_3018	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
Tint_3025	COG3668	Plasmid stabilization system
Tint_3027	COG0367	asparagine synthase
Tint_3036	COG0431	NADPH-dependent FMN reductase
Tint_3039	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
Tint_3050	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
Tint_3060	COG4654	Cytochrome c, class I
Tint_3061	COG0243	molybdopterin cofactor binding
Tint_3062	COG0723	plastoquinol--plastocyanin reductase activity
Tint_3066	COG2132	Multicopper oxidase
Tint_3069	COG0745	RESPONSE REGULATOR receiver
Tint_3073	COG3039	Transposase
Tint_3074	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
Tint_3077	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
Tint_3079	COG0298	carbon dioxide binding
Tint_3081	COG1773	rubredoxin
Tint_3084	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
Tint_3085	COG0375	protein maturation
Tint_3087	COG2204	response regulator
Tint_3088	COG4191	Histidine kinase
Tint_3092	COG0298	carbon dioxide binding
Tint_3093	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
Tint_3103	COG0582	viral genome integration into host DNA
Tint_3105	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
Tint_3106	COG0085	RNA polymerase activity
Tint_3107	COG0222	ribosome binding
Tint_3108	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
Tint_3109	COG0081	regulation of translation
Tint_3110	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
Tint_3113	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
Tint_3114	COG0134	indole-3-glycerol-phosphate synthase activity
Tint_3115	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
Tint_3121	COG0546	phosphoglycolate phosphatase activity
Tint_3122	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
Tint_3123	COG2967	ApaG domain
Tint_3125	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
Tint_3127	COG2354	Protein conserved in bacteria
Tint_3128	COG0730	response to heat
Tint_3131	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
Tint_3132	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
Tint_3134	COG2814	Major facilitator Superfamily
Tint_3137	COG2321	neutral zinc metallopeptidase
Tint_3143	COG1305	Transglutaminase-like
Tint_3148	COG2847	Copper chaperone PCu(A)C
Tint_3149	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
Tint_3152	COG2010	Cytochrome c
Tint_3155	COG2015	COG2015, Alkyl sulfatase and related hydrolases
Tint_3156	COG1914	H( )-stimulated, divalent metal cation uptake system
Tint_3160	COG0635	Involved in the biosynthesis of porphyrin-containing compound
Tint_3161	COG2095	MarC family integral membrane protein
Tint_3162	COG0730	response to heat
Tint_3166	COG0357	Ribosomal RNA small subunit methyltransferase G
Tint_3167	COG1192	Involved in chromosome partitioning
Tint_3169	COG1475	DNA binding
Tint_3172	COG3447	MASE1 domain protein
Tint_3172	COG5002	protein histidine kinase activity
Tint_3172	COG5001	Diguanylate cyclase
Tint_3180	COG1620	l-lactate permease
Tint_3182	COG2271	Major facilitator Superfamily
Tint_3183	COG1484	DNA-dependent DNA replication
Tint_3186	COG0640	Transcriptional regulator
Tint_3190	COG0559	Belongs to the binding-protein-dependent transport system permease family
Tint_3193	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
Tint_3194	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
Tint_3198	COG0230	Belongs to the bacterial ribosomal protein bL34 family
Tint_3199	COG0789	Transcriptional regulator
Tint_3212	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
Tint_3213	COG0672	)-iron permease
Tint_3216	COG0789	Transcriptional regulator
Tint_3224	COG1196	nuclear chromosome segregation
Tint_3225	COG3041	Addiction module toxin RelE StbE family
Tint_3226	COG3077	Addiction module antitoxin, RelB DinJ family
Tint_3242	COG1733	regulation of RNA biosynthetic process
Tint_3248	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
Tint_3256	COG1733	regulation of RNA biosynthetic process