locus-tag	class	description
THII_0001	COG0542	response to heat
THII_0018	COG2234	aminopeptidase activity
THII_0019	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
THII_0020	COG4589	Belongs to the CDS family
THII_0027	COG0243	molybdopterin cofactor binding
THII_0028	COG0463	Glycosyl transferase, family 2
THII_0029	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
THII_0031	COG0287	Prephenate dehydrogenase
THII_0032	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
THII_0034	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
THII_0036	COG0776	regulation of translation
THII_0037	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
THII_0038	COG0284	orotidine-5'-phosphate decarboxylase activity
THII_0039	COG1011	Hydrolase
THII_0041	COG0653	protein targeting
THII_0047	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
THII_0048	COG0084	hydrolase, TatD family'
THII_0049	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
THII_0050	COG5002	protein histidine kinase activity
THII_0050	COG5001	Diguanylate cyclase
THII_0062	COG1752	Esterase of the alpha-beta hydrolase superfamily
THII_0065	COG3118	belongs to the thioredoxin family
THII_0067	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
THII_0068	COG0418	dihydroorotase activity
THII_0071	COG2831	hemolysin activation secretion protein
THII_0075	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
THII_0079	COG3335	DDE superfamily endonuclease
THII_0090	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
THII_0091	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
THII_0091	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
THII_0093	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
THII_0095	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
THII_0101	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
THII_0106	COG0859	PFAM glycosyl transferase family 9
THII_0110	COG1999	signal sequence binding
THII_0118	COG0067	glutamate synthase
THII_0118	COG0070	glutamate synthase
THII_0118	COG0069	glutamate synthase activity
THII_0119	COG2226	methyltransferase
THII_0122	COG2311	Membrane
THII_0125	COG1872	DUF167
THII_0129	COG0714	Associated with various cellular activities
THII_0138	COG1136	(ABC) transporter
THII_0138	COG0577	efflux transmembrane transporter activity
THII_0142	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
THII_0142	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
THII_0143	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
THII_0145	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
THII_0146	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
THII_0147	COG0740	serine-type endopeptidase activity
THII_0148	COG0544	peptidyl-prolyl cis-trans isomerase activity
THII_0150	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
THII_0151	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
THII_0154	COG0072	phenylalanine-tRNA ligase activity
THII_0155	COG0776	regulation of translation
THII_0157	COG0316	Belongs to the HesB IscA family
THII_0176	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
THII_0177	COG0860	N-Acetylmuramoyl-L-alanine amidase
THII_0178	COG0330	HflC and HflK could
THII_0181	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
THII_0184	COG0837	glucose binding
THII_0185	COG1215	transferase activity, transferring glycosyl groups
THII_0186	COG4636	protein conserved in cyanobacteria
THII_0189	COG2205	protein histidine kinase activity
THII_0189	COG0784	Response regulator, receiver
THII_0191	COG1254	Belongs to the acylphosphatase family
THII_0195	COG2080	2 iron, 2 sulfur cluster binding
THII_0196	COG0527	aspartate kinase activity
THII_0197	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
THII_0204	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
THII_0209	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
THII_0214	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
THII_0216	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
THII_0216	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
THII_0217	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
THII_0223	COG4206	TonB-dependent receptor
THII_0231	COG1846	Transcriptional regulator
THII_0233	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
THII_0242	COG1597	lipid kinase activity
THII_0243	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
THII_0246	COG0477	Major facilitator Superfamily
THII_0248	COG1758	RNA polymerase activity
THII_0249	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
THII_0250	COG3079	Belongs to the UPF0149 family
THII_0251	COG0006	proline dipeptidase activity
THII_0257	COG0174	glutamine synthetase
THII_0259	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
THII_0260	COG1361	Conserved repeat domain
THII_0261	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
THII_0262	COG0424	maF-like protein
THII_0267	COG0784	Response regulator, receiver
THII_0267	COG2205	protein histidine kinase activity
THII_0267	COG2198	Histidine kinase
THII_0270	COG4654	Cytochrome c, class I
THII_0271	COG0243	molybdopterin cofactor binding
THII_0279	COG4636	protein conserved in cyanobacteria
THII_0286	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
THII_0287	COG0203	ribosomal protein L17
THII_0288	COG0202	RNA polymerase activity
THII_0289	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
THII_0290	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
THII_0291	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
THII_0292	COG0201	protein transport
THII_0293	COG0200	Binds to the 23S rRNA
THII_0294	COG1841	ribosomal large subunit assembly
THII_0295	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
THII_0296	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
THII_0297	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
THII_0298	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
THII_0299	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
THII_0300	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
THII_0301	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
THII_0302	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
THII_0304	COG0255	Belongs to the universal ribosomal protein uL29 family
THII_0305	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
THII_0306	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
THII_0307	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
THII_0308	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
THII_0309	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
THII_0310	COG0089	rRNA binding
THII_0311	COG0088	Forms part of the polypeptide exit tunnel
THII_0312	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
THII_0313	COG0051	transcription antitermination factor activity, RNA binding
THII_0314	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
THII_0315	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
THII_0316	COG0049	tRNA binding
THII_0317	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
THII_0324	COG3909	cytochrome
THII_0328	COG2815	serine threonine protein kinase
THII_0328	COG0515	serine threonine protein kinase
THII_0330	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
THII_0331	COG2205	protein histidine kinase activity
THII_0331	COG5002	protein histidine kinase activity
THII_0331	COG0784	Response regulator, receiver
THII_0334	COG2010	Cytochrome c
THII_0336	COG0714	Associated with various cellular activities
THII_0347	COG1404	Belongs to the peptidase S8 family
THII_0348	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
THII_0349	COG0071	Belongs to the small heat shock protein (HSP20) family
THII_0350	COG5002	protein histidine kinase activity
THII_0351	COG2957	Belongs to the agmatine deiminase family
THII_0354	COG3706	GGDEF domain
THII_0354	COG0745	RESPONSE REGULATOR receiver
THII_0355	COG2268	Band 7 protein
THII_0356	COG1585	Membrane protein implicated in regulation of membrane protease activity
THII_0360	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
THII_0361	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
THII_0365	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
THII_0366	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
THII_0367	COG0505	Belongs to the CarA family
THII_0379	COG0205	6-phosphofructokinase activity
THII_0383	COG1121	(ABC) transporter
THII_0384	COG1108	ABC-type Mn2 Zn2 transport systems permease components
THII_0388	COG0523	cobalamin synthesis protein
THII_0392	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
THII_0407	COG1643	Atp-dependent helicase
THII_0410	COG0037	tRNA processing
THII_0411	COG0326	Molecular chaperone. Has ATPase activity
THII_0414	COG2949	membrane
THII_0417	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
THII_0418	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
THII_0419	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
THII_0420	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
THII_0421	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
THII_0423	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
THII_0425	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
THII_0430	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
THII_0431	COG1053	succinate dehydrogenase
THII_0433	COG2009	succinate dehydrogenase
THII_0436	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
THII_0443	COG2205	protein histidine kinase activity
THII_0443	COG0784	Response regulator, receiver
THII_0444	COG3437	response regulator, receiver
THII_0444	COG0784	Response regulator, receiver
THII_0446	COG1216	Glycosyl transferase, family 2
THII_0461	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
THII_0463	COG0281	malic enzyme
THII_0463	COG0280	phosphate acetyltransferase
THII_0464	COG1156	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit
THII_0470	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
THII_0473	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
THII_0474	COG0242	peptide deformylase activity
THII_0475	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
THII_0477	COG0827	DNA restriction-modification system
THII_0478	COG0827	DNA restriction-modification system
THII_0482	COG1690	Belongs to the RtcB family
THII_0485	COG1136	(ABC) transporter
THII_0487	COG1136	(ABC) transporter
THII_0488	COG0577	efflux transmembrane transporter activity
THII_0488	COG1136	(ABC) transporter
THII_0491	COG1999	signal sequence binding
THII_0492	COG2204	response regulator
THII_0496	COG1943	Transposase
THII_0500	COG5002	protein histidine kinase activity
THII_0500	COG0784	Response regulator, receiver
THII_0503	COG1477	protein flavinylation
THII_0512	COG0217	transcriptional regulatory protein
THII_0513	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
THII_0515	COG2267	carboxylic ester hydrolase activity
THII_0517	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
THII_0518	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
THII_0520	COG0649	NAD binding
THII_0533	COG2224	Isocitrate lyase
THII_0534	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
THII_0535	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
THII_0538	COG0529	Catalyzes the synthesis of activated sulfate
THII_0541	COG2202	Pas domain
THII_0541	COG2205	protein histidine kinase activity
THII_0543	COG3106	COG3106 Predicted ATPase
THII_0549	COG2201	protein-glutamate methylesterase activity
THII_0550	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
THII_0552	COG0840	transmembrane signaling receptor activity
THII_0554	COG2198	Histidine kinase
THII_0554	COG0643	Histidine kinase
THII_0555	COG0745	RESPONSE REGULATOR receiver
THII_0558	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
THII_0559	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
THII_0561	COG0322	excinuclease ABC activity
THII_0562	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
THII_0568	COG1598	PFAM Uncharacterised protein family UPF0150
THII_0571	COG4115	mRNA cleavage
THII_0572	COG2161	toxin-antitoxin pair type II binding
THII_0579	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
THII_0584	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
THII_0586	COG2037	Catalyzes the transfer of a formyl group from 5-formyl tetrahydromethanopterin (5-formyl-H(4)MPT) to methanofuran (MFR) so as to produce formylmethanofuran (formyl-MFR) and tetrahydromethanopterin (H(4)MPT)
THII_0592	COG1024	Enoyl-CoA hydratase
THII_0592	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
THII_0593	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
THII_0594	COG0285	dihydrofolate synthase activity
THII_0595	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
THII_0596	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
THII_0596	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
THII_0604	COG2076	Multidrug Resistance protein
THII_0605	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
THII_0611	COG2221	Nitrite and sulphite reductase 4Fe-4S
THII_0612	COG2221	Nitrite and sulphite reductase 4Fe-4S
THII_0613	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
THII_0614	COG2923	Belongs to the DsrF TusC family
THII_0616	COG2920	part of a sulfur-relay system
THII_0619	COG0493	'glutamate synthase
THII_0623	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
THII_0634	COG1074	ATP-dependent DNA helicase activity
THII_0636	COG5002	protein histidine kinase activity
THII_0636	COG2205	protein histidine kinase activity
THII_0636	COG0784	Response regulator, receiver
THII_0637	COG0438	transferase activity, transferring glycosyl groups
THII_0640	COG1196	nuclear chromosome segregation
THII_0644	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
THII_0647	COG0540	Belongs to the ATCase OTCase family
THII_0648	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
THII_0649	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
THII_0650	COG1678	Uncharacterized ACR, COG1678
THII_0655	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
THII_0655	COG4797	methyltransferase
THII_0657	COG0583	DNA-binding transcription factor activity
THII_0662	COG4133	protoheme IX ABC transporter activity
THII_0663	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
THII_0667	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
THII_0669	COG0546	phosphoglycolate phosphatase activity
THII_0670	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
THII_0674	COG0318	PFAM AMP-dependent synthetase and ligase
THII_0682	COG0601	transmembrane transport
THII_0687	COG2972	Histidine kinase
THII_0687	COG0745	RESPONSE REGULATOR receiver
THII_0688	COG1305	Transglutaminase-like
THII_0694	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
THII_0695	COG0163	prenyltransferase activity
THII_0703	COG3527	Alpha-acetolactate decarboxylase
THII_0706	COG2105	PFAM AIG2 family protein
THII_0706	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
THII_0707	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
THII_0708	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
THII_0709	COG0505	Belongs to the CarA family
THII_0712	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
THII_0713	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
THII_0716	COG0438	transferase activity, transferring glycosyl groups
THII_0716	COG1216	Glycosyl transferase, family 2
THII_0717	COG1216	Glycosyl transferase, family 2
THII_0717	COG0438	transferase activity, transferring glycosyl groups
THII_0726	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
THII_0727	COG0706	membrane insertase activity
THII_0734	COG0463	Glycosyl transferase, family 2
THII_0735	COG3551	Protein conserved in bacteria
THII_0736	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
THII_0737	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
THII_0738	COG0463	Glycosyl transferase, family 2
THII_0739	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
THII_0743	COG0673	inositol 2-dehydrogenase activity
THII_0744	COG3240	lipase activity
THII_0747	COG0742	ribosomal rna small subunit methyltransferase
THII_0748	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
THII_0750	COG5002	protein histidine kinase activity
THII_0750	COG0784	Response regulator, receiver
THII_0752	COG0165	Argininosuccinate lyase
THII_0754	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
THII_0760	COG0463	Glycosyl transferase, family 2
THII_0762	COG1132	(ABC) transporter
THII_0764	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
THII_0765	COG2885	chlorophyll binding
THII_0767	COG0795	lipopolysaccharide-transporting ATPase activity
THII_0770	COG3954	Phosphoribulokinase
THII_0774	COG0784	Response regulator, receiver
THII_0774	COG5002	protein histidine kinase activity
THII_0774	COG2198	Histidine kinase
THII_0778	COG0493	'glutamate synthase
THII_0778	COG0543	2 iron, 2 sulfur cluster binding
THII_0780	COG0552	protein localization to endoplasmic reticulum
THII_0781	COG2884	Cell division ATP-binding protein ftsE
THII_0782	COG2177	Part of the ABC transporter FtsEX involved in
THII_0784	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
THII_0785	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
THII_0792	COG3620	sequence-specific DNA binding
THII_0795	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
THII_0795	COG0731	radical SAM domain protein
THII_0798	COG3206	protein involved in exopolysaccharide biosynthesis
THII_0798	COG0489	protein tyrosine kinase activity
THII_0802	COG0745	RESPONSE REGULATOR receiver
THII_0803	COG4191	Histidine kinase
THII_0805	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
THII_0806	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
THII_0808	COG1136	(ABC) transporter
THII_0814	COG0494	nUDIX hydrolase
THII_0816	COG3220	belongs to the UPF0276 family
THII_0821	COG2911	Protein conserved in bacteria
THII_0823	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
THII_0829	COG0463	Glycosyl transferase, family 2
THII_0834	COG1301	dicarboxylic acid transport
THII_0835	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
THII_0837	COG1028	Short-chain dehydrogenase reductase Sdr
THII_0839	COG0183	Belongs to the thiolase family
THII_0841	COG3260	NADH ubiquinone oxidoreductase 20
THII_0842	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
THII_0845	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
THII_0846	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
THII_0847	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
THII_0850	COG2969	positive regulation of protein catabolic process
THII_0851	COG2857	Cytochrome c1
THII_0852	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
THII_0853	COG0723	plastoquinol--plastocyanin reductase activity
THII_0854	COG1450	Type ii and iii secretion system protein
THII_0856	COG2165	general secretion pathway protein
THII_0858	COG2165	general secretion pathway protein
THII_0863	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
THII_0864	COG0640	Transcriptional regulator
THII_0865	COG0798	PFAM Bile acid sodium symporter
THII_0866	COG0701	Predicted permease
THII_0868	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
THII_0872	COG2319	Wd-40 repeat
THII_0872	COG4249	Peptidase C14 caspase catalytic subunit p20
THII_0875	COG2890	protein-(glutamine-N5) methyltransferase activity
THII_0878	COG0745	RESPONSE REGULATOR receiver
THII_0881	COG1619	proteins homologs of microcin C7 resistance protein MccF
THII_0886	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
THII_0891	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
THII_0903	COG2027	D-alanyl-D-alanine carboxypeptidase
THII_0906	COG0464	growth
THII_0914	COG0651	ATP synthesis coupled electron transport
THII_0915	COG0649	NAD binding
THII_0919	COG0745	RESPONSE REGULATOR receiver
THII_0919	COG3706	GGDEF domain
THII_0920	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
THII_0921	COG0784	Response regulator, receiver
THII_0921	COG2205	protein histidine kinase activity
THII_0921	COG5002	protein histidine kinase activity
THII_0927	COG3119	arylsulfatase activity
THII_0928	COG2003	Belongs to the UPF0758 family
THII_0929	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
THII_0931	COG0602	queuosine metabolic process
THII_0936	COG0494	nUDIX hydrolase
THII_0938	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
THII_0938	COG4797	methyltransferase
THII_0940	COG1388	LysM domain
THII_0940	COG0741	lytic transglycosylase activity
THII_0943	COG2197	response regulator
THII_0947	COG3103	Sh3 type 3 domain protein
THII_0947	COG0791	NLP P60 protein
THII_0947	COG1388	LysM domain
THII_0948	COG3228	Belongs to the MtfA family
THII_0949	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
THII_0950	COG0840	transmembrane signaling receptor activity
THII_0951	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
THII_0952	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
THII_0961	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
THII_0962	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
THII_0971	COG0714	Associated with various cellular activities
THII_0972	COG0859	PFAM glycosyl transferase family 9
THII_0980	COG0343	queuine tRNA-ribosyltransferase activity
THII_0981	COG2161	toxin-antitoxin pair type II binding
THII_0982	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
THII_0982	COG1648	precorrin-2 dehydrogenase activity
THII_0983	COG0425	Belongs to the sulfur carrier protein TusA family
THII_0984	COG2210	Belongs to the sulfur carrier protein TusA family
THII_0985	COG0277	FAD linked oxidase domain protein
THII_0993	COG1943	Transposase
THII_0999	COG3501	Rhs element vgr protein
THII_1001	COG1662	PFAM IS1 transposase
THII_1019	COG2205	protein histidine kinase activity
THII_1019	COG0784	Response regulator, receiver
THII_1019	COG5002	protein histidine kinase activity
THII_1021	COG2205	protein histidine kinase activity
THII_1021	COG4191	Histidine kinase
THII_1021	COG0745	RESPONSE REGULATOR receiver
THII_1025	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
THII_1026	COG0354	folic acid binding
THII_1027	COG0739	heme binding
THII_1029	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
THII_1031	COG0473	3-isopropylmalate dehydrogenase activity
THII_1032	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
THII_1034	COG0101	tRNA pseudouridine synthase activity
THII_1036	COG2205	protein histidine kinase activity
THII_1036	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
THII_1037	COG3706	GGDEF domain
THII_1037	COG0745	RESPONSE REGULATOR receiver
THII_1038	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
THII_1039	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
THII_1046	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
THII_1051	COG2226	methyltransferase
THII_1056	COG0489	protein tyrosine kinase activity
THII_1057	COG2046	Belongs to the sulfate adenylyltransferase family
THII_1070	COG2226	methyltransferase
THII_1083	COG1708	protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity
THII_1084	COG1708	protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity
THII_1091	COG0463	Glycosyl transferase, family 2
THII_1103	COG1943	Transposase
THII_1110	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
THII_1112	COG0463	Glycosyl transferase, family 2
THII_1118	COG0730	response to heat
THII_1126	COG4245	von Willebrand factor, type A
THII_1130	COG0745	RESPONSE REGULATOR receiver
THII_1130	COG3706	GGDEF domain
THII_1131	COG2205	protein histidine kinase activity
THII_1131	COG2202	Pas domain
THII_1133	COG1210	Utp--glucose-1-phosphate uridylyltransferase
THII_1134	COG2020	methyltransferase activity
THII_1141	COG0463	Glycosyl transferase, family 2
THII_1142	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
THII_1151	COG2239	Acts as a magnesium transporter
THII_1153	COG3025	triphosphatase activity
THII_1154	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
THII_1158	COG0606	chelatase, subunit chli
THII_1160	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
THII_1161	COG0784	Response regulator, receiver
THII_1161	COG2205	protein histidine kinase activity
THII_1161	COG5002	protein histidine kinase activity
THII_1165	COG0811	peptide transport
THII_1168	COG4772	TonB-dependent receptor
THII_1173	COG2171	N-acyltransferase activity
THII_1175	COG0779	Required for maturation of 30S ribosomal subunits
THII_1176	COG2251	uridine kinase activity
THII_1176	COG0195	Participates in both transcription termination and antitermination
THII_1178	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
THII_1179	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
THII_1180	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
THII_1181	COG1185	polyribonucleotide nucleotidyltransferase activity
THII_1191	COG0784	Response regulator, receiver
THII_1191	COG2205	protein histidine kinase activity
THII_1191	COG5002	protein histidine kinase activity
THII_1195	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
THII_1196	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
THII_1197	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
THII_1199	COG0275	rRNA processing
THII_1200	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
THII_1202	COG0515	serine threonine protein kinase
THII_1202	COG1262	PFAM Formylglycine-generating sulfatase enzyme
THII_1208	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
THII_1209	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
THII_1210	COG1862	Preprotein translocase
THII_1211	COG0254	rRNA binding
THII_1213	COG4636	protein conserved in cyanobacteria
THII_1214	COG0187	DNA topoisomerase II activity
THII_1217	COG0514	ATP-dependent DNA helicase (RecQ)
THII_1218	COG2311	Membrane
THII_1219	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
THII_1225	COG0463	Glycosyl transferase, family 2
THII_1227	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
THII_1233	COG3243	poly(R)-hydroxyalkanoic acid synthase
THII_1235	COG1472	Belongs to the glycosyl hydrolase 3 family
THII_1239	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
THII_1245	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
THII_1249	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
THII_1250	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
THII_1254	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
THII_1255	COG1137	ATPase activity
THII_1256	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
THII_1258	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
THII_1268	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
THII_1270	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
THII_1270	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
THII_1275	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
THII_1276	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
THII_1277	COG1196	nuclear chromosome segregation
THII_1277	COG0741	lytic transglycosylase activity
THII_1277	COG0739	heme binding
THII_1278	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
THII_1285	COG0840	transmembrane signaling receptor activity
THII_1299	COG3243	poly(R)-hydroxyalkanoic acid synthase
THII_1300	COG0557	exoribonuclease II activity
THII_1301	COG5002	protein histidine kinase activity
THII_1301	COG0784	Response regulator, receiver
THII_1301	COG2205	protein histidine kinase activity
THII_1302	COG0521	Mo-molybdopterin cofactor biosynthetic process
THII_1305	COG0795	lipopolysaccharide-transporting ATPase activity
THII_1306	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
THII_1311	COG0033	Phosphoglucomutase
THII_1314	COG1136	(ABC) transporter
THII_1317	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
THII_1319	COG3107	peptidoglycan biosynthetic process
THII_1320	COG0792	nuclease activity
THII_1321	COG1131	(ABC) transporter
THII_1324	COG0741	lytic transglycosylase activity
THII_1324	COG1196	nuclear chromosome segregation
THII_1324	COG0739	heme binding
THII_1325	COG0501	Belongs to the peptidase M48B family
THII_1328	COG2814	Major facilitator Superfamily
THII_1330	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
THII_1331	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
THII_1332	COG0494	nUDIX hydrolase
THII_1333	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
THII_1334	COG0107	imidazoleglycerol-phosphate synthase activity
THII_1336	COG0140	phosphoribosyl-ATP diphosphatase activity
THII_1339	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
THII_1340	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
THII_1341	COG0805	protein transport
THII_1346	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
THII_1347	COG1088	dTDP-glucose 4,6-dehydratase activity
THII_1365	COG0784	Response regulator, receiver
THII_1365	COG2205	protein histidine kinase activity
THII_1368	COG0142	geranyltranstransferase activity
THII_1376	COG0753	catalase activity
THII_1378	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
THII_1379	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
THII_1380	COG0653	protein targeting
THII_1381	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
THII_1382	COG0352	thiamine-phosphate diphosphorylase activity
THII_1384	COG1215	transferase activity, transferring glycosyl groups
THII_1390	COG4166	transmembrane transport
THII_1392	COG4174	ABC transporter (Permease)
THII_1393	COG4239	(ABC) transporter, permease
THII_1397	COG0105	UTP biosynthetic process
THII_1398	COG0820	rRNA (adenine-C2-)-methyltransferase activity
THII_1400	COG1426	Protein conserved in bacteria
THII_1401	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
THII_1404	COG0315	cyclic pyranopterin monophosphate synthase activity
THII_1406	COG0513	Belongs to the DEAD box helicase family
THII_1411	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
THII_1412	COG2137	regulation of response to DNA damage stimulus
THII_1413	COG1372	Participates in initiation and elongation during chromosome replication
THII_1413	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
THII_1418	COG2217	Heavy metal translocating P-type atpase
THII_1420	COG1350	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
THII_1424	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
THII_1425	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
THII_1426	COG2835	tetraacyldisaccharide 4'-kinase activity
THII_1427	COG1663	tetraacyldisaccharide 4'-kinase activity
THII_1428	COG0848	biopolymer transport protein
THII_1429	COG0811	peptide transport
THII_1430	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
THII_1435	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
THII_1435	COG4797	methyltransferase
THII_1438	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
THII_1441	COG0166	Belongs to the GPI family
THII_1442	COG1640	4-alpha-glucanotransferase
THII_1444	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
THII_1457	COG2062	phosphohistidine phosphatase, SixA
THII_1458	COG0708	Exodeoxyribonuclease III
THII_1459	COG0612	Peptidase, M16
THII_1460	COG0612	Peptidase, M16
THII_1461	COG1040	competence protein
THII_1463	COG1511	domain protein
THII_1463	COG3264	Mechanosensitive ion channel
THII_1465	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
THII_1466	COG1469	GTP cyclohydrolase I activity
THII_1472	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
THII_1473	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
THII_1475	COG2862	Uncharacterized protein family, UPF0114
THII_1489	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
THII_1490	COG0459	protein refolding
THII_1491	COG1575	Belongs to the MenA family. Type 1 subfamily
THII_1493	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
THII_1495	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
THII_1500	COG1858	cytochrome C peroxidase
THII_1503	COG5265	(ABC) transporter
THII_1510	COG2308	Evidence 4 Homologs of previously reported genes of
THII_1512	COG4783	chaperone-mediated protein folding
THII_1514	COG0784	Response regulator, receiver
THII_1514	COG2205	protein histidine kinase activity
THII_1514	COG5002	protein histidine kinase activity
THII_1517	COG3437	response regulator, receiver
THII_1517	COG0784	Response regulator, receiver
THII_1520	COG1943	Transposase
THII_1521	COG3259	Nickel-dependent hydrogenase
THII_1522	COG1941	NADH ubiquinone oxidoreductase 20 kDa subunit
THII_1523	COG3383	formate dehydrogenase (NAD+) activity
THII_1524	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
THII_1525	COG0823	Involved in the tonB-independent uptake of proteins
THII_1529	COG0811	peptide transport
THII_1530	COG0824	Thioesterase
THII_1531	COG2255	four-way junction helicase activity
THII_1537	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
THII_1540	COG5002	protein histidine kinase activity
THII_1540	COG2198	Histidine kinase
THII_1540	COG0784	Response regulator, receiver
THII_1541	COG5001	Diguanylate cyclase
THII_1541	COG4251	negative regulation of phosphorylation
THII_1541	COG3706	GGDEF domain
THII_1541	COG2203	Gaf domain
THII_1542	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
THII_1543	COG0564	pseudouridine synthase activity
THII_1546	COG0339	signal peptide processing
THII_1547	COG0058	SHG alpha-glucan phosphorylase activity
THII_1548	COG0651	ATP synthesis coupled electron transport
THII_1549	COG0650	Formate hydrogenlyase subunit 4
THII_1554	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
THII_1562	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
THII_1565	COG0227	Belongs to the bacterial ribosomal protein bL28 family
THII_1567	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
THII_1568	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
THII_1569	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
THII_1569	COG4797	methyltransferase
THII_1570	COG0745	RESPONSE REGULATOR receiver
THII_1571	COG2205	protein histidine kinase activity
THII_1575	COG0617	tRNA 3'-terminal CCA addition
THII_1576	COG1090	epimerase
THII_1585	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
THII_1585	COG4191	Histidine kinase
THII_1592	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
THII_1595	COG2226	methyltransferase
THII_1599	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
THII_1602	COG2264	protein methyltransferase activity
THII_1615	COG3278	Belongs to the heme-copper respiratory oxidase family
THII_1618	COG2010	Cytochrome c
THII_1619	COG1966	Carbon starvation protein
THII_1624	COG0745	RESPONSE REGULATOR receiver
THII_1625	COG2205	protein histidine kinase activity
THII_1631	COG5002	protein histidine kinase activity
THII_1631	COG0784	Response regulator, receiver
THII_1633	COG0138	bifunctional purine biosynthesis protein purh
THII_1634	COG1218	3'(2'),5'-bisphosphate nucleotidase
THII_1646	COG0812	UDP-N-acetylmuramate dehydrogenase activity
THII_1649	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
THII_1658	COG0463	Glycosyl transferase, family 2
THII_1663	COG1131	(ABC) transporter
THII_1664	COG1132	(ABC) transporter
THII_1685	COG4137	Cytochrome C assembly protein
THII_1691	COG0446	pyridine nucleotide-disulphide oxidoreductase
THII_1692	COG2863	cytochrome
THII_1694	COG3005	denitrification pathway
THII_1695	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
THII_1699	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
THII_1701	COG0463	Glycosyl transferase, family 2
THII_1701	COG1216	Glycosyl transferase, family 2
THII_1707	COG1215	transferase activity, transferring glycosyl groups
THII_1709	COG0438	transferase activity, transferring glycosyl groups
THII_1710	COG0110	maltose O-acetyltransferase activity
THII_1711	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
THII_1714	COG0297	glycogen (starch) synthase activity
THII_1716	COG0247	lactate metabolic process
THII_1717	COG0604	alcohol dehydrogenase
THII_1720	COG0492	ferredoxin-NADP+ reductase activity
THII_1721	COG1459	type II secretion system
THII_1734	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
THII_1735	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
THII_1736	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
THII_1739	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
THII_1741	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
THII_1742	COG0575	Belongs to the CDS family
THII_1743	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
THII_1744	COG0233	cytoplasmic translational termination
THII_1745	COG0528	UMP kinase activity
THII_1746	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
THII_1747	COG0052	Belongs to the universal ribosomal protein uS2 family
THII_1748	COG0024	Methionine aminopeptidase
THII_1749	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
THII_1750	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
THII_1751	COG0314	molybdopterin synthase activity
THII_1755	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
THII_1761	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
THII_1764	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
THII_1765	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
THII_1772	COG0728	peptidoglycan biosynthetic process
THII_1773	COG0196	riboflavin kinase activity
THII_1776	COG4251	negative regulation of phosphorylation
THII_1776	COG3706	GGDEF domain
THII_1776	COG2203	Gaf domain
THII_1776	COG5001	Diguanylate cyclase
THII_1777	COG5002	protein histidine kinase activity
THII_1778	COG0243	molybdopterin cofactor binding
THII_1781	COG2146	nitrite reductase [NAD(P)H] activity
THII_1782	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
THII_1783	COG2223	nitrite transmembrane transporter activity
THII_1784	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
THII_1784	COG1116	anion transmembrane transporter activity
THII_1785	COG3707	response regulator
THII_1789	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
THII_1790	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
THII_1794	COG0815	Transfers the fatty acyl group on membrane lipoproteins
THII_1796	COG4535	Mg2 and Co2 transporter CorC
THII_1797	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
THII_1798	COG1702	phosphate starvation-inducible protein PhoH
THII_1799	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
THII_1801	COG0037	tRNA processing
THII_1804	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
THII_1806	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
THII_1823	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
THII_1831	COG1943	Transposase
THII_1832	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
THII_1834	COG0187	DNA topoisomerase II activity
THII_1835	COG2161	toxin-antitoxin pair type II binding
THII_1836	COG4115	mRNA cleavage
THII_1837	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
THII_1847	COG3706	GGDEF domain
THII_1847	COG0745	RESPONSE REGULATOR receiver
THII_1848	COG2920	part of a sulfur-relay system
THII_1852	COG0495	leucyl-tRNA aminoacylation
THII_1862	COG1049	propionate catabolic process, 2-methylcitrate cycle
THII_1870	COG3956	TIGRFAM MazG family protein
THII_1873	COG3959	Transketolase, thiamine diphosphate binding domain
THII_1874	COG3958	Transketolase
THII_1875	COG1850	ribulose-bisphosphate carboxylase activity
THII_1876	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
THII_1878	COG0729	surface antigen
THII_1880	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
THII_1881	COG2078	PFAM AMMECR1 domain protein
THII_1882	COG1355	regulation of microtubule-based process
THII_1884	COG2205	protein histidine kinase activity
THII_1884	COG2198	Histidine kinase
THII_1884	COG0784	Response regulator, receiver
THII_1884	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
THII_1887	COG1763	Mo-molybdopterin cofactor biosynthetic process
THII_1888	COG0746	molybdenum cofactor guanylyltransferase activity
THII_1889	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
THII_1893	COG1595	DNA-templated transcription, initiation
THII_1904	COG0116	Belongs to the methyltransferase superfamily
THII_1904	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
THII_1905	COG0828	Belongs to the bacterial ribosomal protein bS21 family
THII_1908	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
THII_1909	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
THII_1912	COG1215	transferase activity, transferring glycosyl groups
THII_1913	COG5001	Diguanylate cyclase
THII_1913	COG3300	MHYT domain
THII_1914	COG0123	including yeast histone deacetylase and acetoin utilization protein
THII_1915	COG0415	Belongs to the DNA photolyase family
THII_1917	COG0488	(ABC) transporter
THII_1919	COG1394	ATPase activity, coupled to movement of substances
THII_1923	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
THII_1924	COG0840	transmembrane signaling receptor activity
THII_1928	COG0643	Histidine kinase
THII_1928	COG2198	Histidine kinase
THII_1929	COG2201	protein-glutamate methylesterase activity
THII_1935	COG0463	Glycosyl transferase, family 2
THII_1939	COG2442	InterPro IPR007367
THII_1945	COG1943	Transposase
THII_1954	COG2205	protein histidine kinase activity
THII_1954	COG0784	Response regulator, receiver
THII_1956	COG3706	GGDEF domain
THII_1959	COG2226	methyltransferase
THII_1960	COG2967	ApaG domain
THII_1962	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
THII_1963	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
THII_1969	COG1131	(ABC) transporter
THII_1977	COG0512	Glutamine amidotransferase of anthranilate synthase
THII_1980	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
THII_1981	COG0237	dephospho-CoA kinase activity
THII_1982	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
THII_1987	COG0840	transmembrane signaling receptor activity
THII_1988	COG0643	Histidine kinase
THII_1988	COG2198	Histidine kinase
THII_1991	COG1397	ADP-ribosylglycohydrolase
THII_2036	COG1708	protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity
THII_2042	COG1396	sequence-specific DNA binding
THII_2050	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
THII_2051	COG0742	ribosomal rna small subunit methyltransferase
THII_2053	COG3706	GGDEF domain
THII_2053	COG5001	Diguanylate cyclase
THII_2053	COG4251	negative regulation of phosphorylation
THII_2053	COG2203	Gaf domain
THII_2056	COG0741	lytic transglycosylase activity
THII_2057	COG4717	serine-type aminopeptidase activity
THII_2061	COG0420	3'-5' exonuclease activity
THII_2067	COG1560	Kdo2-lipid A biosynthetic process
THII_2069	COG1459	type II secretion system
THII_2077	COG0438	transferase activity, transferring glycosyl groups
THII_2078	COG3158	transport of potassium into the cell
THII_2081	COG0189	ligase activity
THII_2082	COG0404	The glycine cleavage system catalyzes the degradation of glycine
THII_2083	COG0509	glycine decarboxylation via glycine cleavage system
THII_2084	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
THII_2086	COG2205	protein histidine kinase activity
THII_2090	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
THII_2098	COG3347	Dehydrogenase
THII_2098	COG1028	Short-chain dehydrogenase reductase Sdr
THII_2100	COG3409	Peptidoglycan-binding domain 1 protein
THII_2100	COG3267	Type II secretory pathway component ExeA
THII_2102	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
THII_2103	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
THII_2104	COG0271	Belongs to the BolA IbaG family
THII_2105	COG2350	Protein conserved in bacteria
THII_2106	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
THII_2107	COG2917	probably involved in intracellular septation
THII_2109	COG1127	ABC transporter
THII_2110	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
THII_2114	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
THII_2115	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
THII_2119	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
THII_2120	COG2319	Wd-40 repeat
THII_2120	COG4249	Peptidase C14 caspase catalytic subunit p20
THII_2123	COG0318	PFAM AMP-dependent synthetase and ligase
THII_2123	COG0204	Acyl-transferase
THII_2127	COG3657	addiction module killer protein
THII_2128	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
THII_2132	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
THII_2134	COG4636	protein conserved in cyanobacteria
THII_2136	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
THII_2136	COG0475	glutathione-regulated potassium exporter activity
THII_2139	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
THII_2152	COG1819	glycosyl
THII_2161	COG4659	FMN binding
THII_2163	COG4656	Part of a membrane complex involved in electron transport
THII_2164	COG2878	Part of a membrane complex involved in electron transport
THII_2165	COG4657	Part of a membrane complex involved in electron transport
THII_2168	COG4999	Histidine kinase
THII_2168	COG3437	response regulator, receiver
THII_2168	COG2205	protein histidine kinase activity
THII_2168	COG3850	Histidine kinase
THII_2169	COG3850	Histidine kinase
THII_2169	COG4999	Histidine kinase
THII_2169	COG2205	protein histidine kinase activity
THII_2169	COG3437	response regulator, receiver
THII_2170	COG0736	holo-[acyl-carrier-protein] synthase activity
THII_2171	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
THII_2173	COG1538	Outer membrane efflux protein
THII_2175	COG0840	transmembrane signaling receptor activity
THII_2176	COG0835	chemotaxis
THII_2177	COG0643	Histidine kinase
THII_2177	COG2198	Histidine kinase
THII_2181	COG0084	hydrolase, TatD family'
THII_2184	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
THII_2185	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
THII_2188	COG0840	transmembrane signaling receptor activity
THII_2194	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
THII_2199	COG1662	PFAM IS1 transposase
THII_2201	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
THII_2201	COG3321	synthase
THII_2201	COG1028	Short-chain dehydrogenase reductase Sdr
THII_2201	COG4221	oxidoreductase activity
THII_2202	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
THII_2202	COG1028	Short-chain dehydrogenase reductase Sdr
THII_2202	COG3321	synthase
THII_2202	COG4221	oxidoreductase activity
THII_2202	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
THII_2202	COG1028	Short-chain dehydrogenase reductase Sdr
THII_2202	COG4221	oxidoreductase activity
THII_2202	COG3321	synthase
THII_2204	COG1250	3-hydroxyacyl-CoA dehydrogenase
THII_2206	COG1960	acyl-CoA dehydrogenase activity
THII_2208	COG3321	synthase
THII_2208	COG4221	oxidoreductase activity
THII_2208	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
THII_2208	COG0300	oxidoreductase activity
THII_2209	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
THII_2209	COG1028	Short-chain dehydrogenase reductase Sdr
THII_2209	COG3321	synthase
THII_2209	COG4221	oxidoreductase activity
THII_2217	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
THII_2219	COG3425	synthase
THII_2220	COG1024	Enoyl-CoA hydratase
THII_2238	COG0574	Belongs to the PEP-utilizing enzyme family
THII_2238	COG3848	Pyruvate phosphate dikinase
THII_2244	COG2217	Heavy metal translocating P-type atpase
THII_2249	COG3335	DDE superfamily endonuclease
THII_2258	COG1160	GTP binding
THII_2261	COG1450	Type ii and iii secretion system protein
THII_2262	COG1459	type II secretion system
THII_2263	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
THII_2265	COG0525	valine-tRNA ligase activity
THII_2275	COG2379	hydroxypyruvate reductase
THII_2277	COG1233	COG1233 Phytoene dehydrogenase and related
THII_2279	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
THII_2280	COG2048	Heterodisulfide reductase, subunit B
THII_2288	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
THII_2289	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
THII_2291	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
THII_2292	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
THII_2294	COG2205	protein histidine kinase activity
THII_2294	COG0784	Response regulator, receiver
THII_2296	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
THII_2299	COG0463	Glycosyl transferase, family 2
THII_2300	COG0438	transferase activity, transferring glycosyl groups
THII_2301	COG0463	Glycosyl transferase, family 2
THII_2303	COG0367	asparagine synthase
THII_2305	COG0012	GTP binding
THII_2306	COG0193	aminoacyl-tRNA hydrolase activity
THII_2307	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
THII_2308	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
THII_2309	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
THII_2310	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
THII_2312	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
THII_2313	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
THII_2315	COG2304	oxidoreductase activity
THII_2316	COG1032	radical SAM domain protein
THII_2325	COG0784	Response regulator, receiver
THII_2325	COG2205	protein histidine kinase activity
THII_2326	COG1183	phosphatidylcholine synthase activity
THII_2327	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
THII_2332	COG0028	Belongs to the TPP enzyme family
THII_2338	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
THII_2339	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
THII_2340	COG1773	rubredoxin
THII_2341	COG1992	Thiamine-phosphate synthase
THII_2341	COG0351	phosphomethylpyrimidine kinase
THII_2342	COG0352	thiamine-phosphate diphosphorylase activity
THII_2343	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
THII_2348	COG0517	IMP dehydrogenase activity
THII_2348	COG0516	GMP reductase activity
THII_2349	COG0432	Pfam Uncharacterised protein family UPF0047
THII_2355	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
THII_2358	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
THII_2359	COG0218	Necessary for normal cell division and for the maintenance of normal septation
THII_2360	COG0542	response to heat
THII_2361	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
THII_2366	COG3178	'Phosphotransferase
THII_2367	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
THII_2368	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
THII_2369	COG0291	Belongs to the bacterial ribosomal protein bL35 family
THII_2370	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
THII_2371	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
THII_2375	COG0784	Response regulator, receiver
THII_2375	COG2205	protein histidine kinase activity
THII_2375	COG5002	protein histidine kinase activity
THII_2378	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
THII_2382	COG4636	protein conserved in cyanobacteria
THII_2390	COG1923	regulation of RNA biosynthetic process
THII_2391	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
THII_2392	COG0330	HflC and HflK could
THII_2393	COG0330	HflC and HflK could
THII_2394	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
THII_2395	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
THII_2396	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
THII_2406	COG0745	RESPONSE REGULATOR receiver
THII_2407	COG2205	protein histidine kinase activity
THII_2407	COG2770	Histidine kinase
THII_2413	COG4660	Part of a membrane complex involved in electron transport
THII_2415	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
THII_2416	COG0357	Ribosomal RNA small subunit methyltransferase G
THII_2425	COG0129	dihydroxy-acid dehydratase activity
THII_2428	COG0758	DNA mediated transformation
THII_2429	COG2922	Belongs to the Smg family
THII_2431	COG0009	L-threonylcarbamoyladenylate synthase
THII_2432	COG0347	Belongs to the P(II) protein family
THII_2433	COG0004	ammonium transporteR
THII_2435	COG2885	chlorophyll binding
THII_2439	COG0484	heat shock protein binding
THII_2440	COG2205	protein histidine kinase activity
THII_2440	COG3850	Histidine kinase
THII_2440	COG4999	Histidine kinase
THII_2440	COG3437	response regulator, receiver
THII_2442	COG2201	protein-glutamate methylesterase activity
THII_2443	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
THII_2444	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
THII_2446	COG0840	transmembrane signaling receptor activity
THII_2447	COG0840	transmembrane signaling receptor activity
THII_2450	COG1139	Iron-sulfur cluster binding protein
THII_2464	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
THII_2465	COG1388	LysM domain
THII_2465	COG3584	3D domain protein
THII_2478	COG0861	Integral membrane protein TerC family
THII_2480	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
THII_2481	COG2165	general secretion pathway protein
THII_2485	COG1662	PFAM IS1 transposase
THII_2488	COG1028	Short-chain dehydrogenase reductase Sdr
THII_2491	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
THII_2493	COG0481	GTPase activity
THII_2494	COG0681	Belongs to the peptidase S26 family
THII_2497	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
THII_2503	COG2267	carboxylic ester hydrolase activity
THII_2507	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
THII_2508	COG2048	Heterodisulfide reductase, subunit B
THII_2514	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
THII_2522	COG2914	Belongs to the UPF0125 (RnfH) family
THII_2527	COG1272	protein, Hemolysin III
THII_2528	COG0784	Response regulator, receiver
THII_2528	COG5002	protein histidine kinase activity
THII_2529	COG0714	Associated with various cellular activities
THII_2531	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
THII_2532	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
THII_2533	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
THII_2534	COG0812	UDP-N-acetylmuramate dehydrogenase activity
THII_2535	COG1181	Belongs to the D-alanine--D-alanine ligase family
THII_2536	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
THII_2539	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
THII_2541	COG0739	heme binding
THII_2545	COG1045	serine acetyltransferase
THII_2548	COG3713	MltA-interacting MipA family protein
THII_2551	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
THII_2552	COG1968	undecaprenyl-diphosphatase activity
THII_2554	COG1229	Formylmethanofuran dehydrogenase subunit A
THII_2564	COG2914	Belongs to the UPF0125 (RnfH) family
THII_2567	COG4658	electron transport chain
THII_2570	COG4657	Part of a membrane complex involved in electron transport
THII_2580	COG5000	phosphorelay sensor kinase activity
THII_2581	COG2204	response regulator
THII_2588	COG3093	addiction module antidote protein HigA
THII_2594	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
THII_2595	COG0825	malonyl-CoA metabolic process
THII_2597	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
THII_2598	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
THII_2603	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
THII_2604	COG4208	sulfate ABC transporter
THII_2605	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
THII_2610	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
THII_2611	COG0563	adenylate kinase activity
THII_2619	COG3335	DDE superfamily endonuclease
THII_2622	COG0574	Belongs to the PEP-utilizing enzyme family
THII_2622	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
THII_2631	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
THII_2640	COG0438	transferase activity, transferring glycosyl groups
THII_2641	COG0297	glycogen (starch) synthase activity
THII_2646	COG1022	Amp-dependent synthetase and ligase
THII_2647	COG3942	CHAP domain
THII_2647	COG1388	LysM domain
THII_2648	COG3942	CHAP domain
THII_2648	COG1388	LysM domain
THII_2650	COG0737	Belongs to the 5'-nucleotidase family
THII_2651	COG1230	cation diffusion facilitator family transporter
THII_2652	COG0586	Pfam SNARE associated Golgi protein
THII_2658	COG1555	photosystem II stabilization
THII_2663	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
THII_2664	COG0596	Alpha beta hydrolase
THII_2666	COG3335	DDE superfamily endonuclease
THII_2670	COG0430	RNA-3'-phosphate cyclase activity
THII_2678	COG1242	4 iron, 4 sulfur cluster binding
THII_2688	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
THII_2689	COG1519	Transferase
THII_2692	COG0747	negative chemotaxis
THII_2693	COG3706	GGDEF domain
THII_2698	COG4636	protein conserved in cyanobacteria
THII_2707	COG1192	Involved in chromosome partitioning
THII_2709	COG0484	heat shock protein binding
THII_2710	COG0443	Heat shock 70 kDa protein
THII_2711	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
THII_2712	COG1420	regulation of RNA biosynthetic process
THII_2713	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
THII_2714	COG2915	High frequency lysogenization protein hflD homolog
THII_2718	COG0482	sulfurtransferase activity
THII_2721	COG0303	'Molybdopterin
THII_2724	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
THII_2725	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
THII_2727	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
THII_2728	COG0081	regulation of translation
THII_2729	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
THII_2730	COG0222	ribosome binding
THII_2731	COG0085	RNA polymerase activity
THII_2732	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
THII_2735	COG1131	(ABC) transporter
THII_2736	COG0842	Transport permease protein
THII_2738	COG1136	(ABC) transporter
THII_2747	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
THII_2748	COG0752	glycyl-tRNA synthetase alpha subunit
THII_2749	COG0751	glycine-tRNA ligase activity
THII_2751	COG0756	dUTP diphosphatase activity
THII_2755	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
THII_2756	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
THII_2760	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
THII_2761	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
THII_2762	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
THII_2763	COG1278	Cold shock
THII_2764	COG0277	FAD linked oxidase domain protein
THII_2770	COG3293	Transposase
THII_2776	COG0641	radical SAM
THII_2781	COG3119	arylsulfatase activity
THII_2782	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
THII_2782	COG3320	Male sterility
THII_2794	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
THII_2795	COG2264	protein methyltransferase activity
THII_2796	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
THII_2799	COG2192	nodulation
THII_2800	COG0635	Involved in the biosynthesis of porphyrin-containing compound
THII_2803	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
THII_2805	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
THII_2806	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
THII_2810	COG1490	D-aminoacyl-tRNA deacylase activity
THII_2811	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
THII_2813	COG2914	Belongs to the UPF0125 (RnfH) family
THII_2815	COG0735	belongs to the Fur family
THII_2825	COG0328	RNA-DNA hybrid ribonuclease activity
THII_2826	COG2226	methyltransferase
THII_2827	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
THII_2828	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
THII_2836	COG2814	Major facilitator Superfamily
THII_2840	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
THII_2841	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
THII_2844	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
THII_2851	COG2314	TM2 domain
THII_2884	COG4263	nitrous-oxide reductase activity
THII_2889	COG0437	4 iron, 4 sulfur cluster binding
THII_2891	COG1131	(ABC) transporter
THII_2907	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
THII_2910	COG1660	Displays ATPase and GTPase activities
THII_2911	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
THII_2912	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
THII_2913	COG0504	CTP synthase activity
THII_2917	COG0211	Belongs to the bacterial ribosomal protein bL27 family
THII_2918	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
THII_2922	COG1475	DNA binding
THII_2925	COG3041	Addiction module toxin RelE StbE family
THII_2931	COG0355	proton-transporting ATP synthase activity, rotational mechanism
THII_2932	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
THII_2933	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
THII_2935	COG0307	riboflavin synthase, alpha
THII_2936	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
THII_2937	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
THII_2938	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
THII_2939	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
THII_2940	COG0356	it plays a direct role in the translocation of protons across the membrane
THII_2942	COG2203	Gaf domain
THII_2942	COG2199	diguanylate cyclase activity
THII_2942	COG2200	EAL domain
THII_2945	COG1007	ATP synthesis coupled electron transport
THII_2948	COG0713	ATP synthesis coupled electron transport
THII_2952	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
THII_2953	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
THII_2954	COG1034	ATP synthesis coupled electron transport
THII_2959	COG0159	tryptophan synthase activity
THII_2960	COG0133	tryptophan synthase activity
THII_2963	COG5002	protein histidine kinase activity
THII_2963	COG5001	Diguanylate cyclase
THII_2966	COG0708	Exodeoxyribonuclease III
THII_2971	COG0215	cysteine-tRNA ligase activity
THII_2972	COG2205	protein histidine kinase activity
THII_2980	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
THII_2981	COG2204	response regulator
THII_2982	COG0268	Binds directly to 16S ribosomal RNA
THII_2986	COG1943	Transposase
THII_2987	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
THII_2987	COG4797	methyltransferase
THII_2988	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
THII_3000	COG0018	arginyl-trna synthetase
THII_3001	COG4115	mRNA cleavage
THII_3016	COG0497	DNA recombination
THII_3018	COG0277	FAD linked oxidase domain protein
THII_3019	COG0047	phosphoribosylformylglycinamidine synthase activity
THII_3019	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
THII_3020	COG4251	negative regulation of phosphorylation
THII_3020	COG3706	GGDEF domain
THII_3020	COG2203	Gaf domain
THII_3020	COG5001	Diguanylate cyclase
THII_3021	COG0402	S-adenosylhomocysteine deaminase activity
THII_3022	COG1902	pentaerythritol trinitrate reductase activity
THII_3037	COG0631	protein serine/threonine phosphatase activity
THII_3038	COG0631	protein serine/threonine phosphatase activity
THII_3039	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
THII_3042	COG4251	negative regulation of phosphorylation
THII_3042	COG5001	Diguanylate cyclase
THII_3042	COG2203	Gaf domain
THII_3042	COG3706	GGDEF domain
THII_3043	COG0784	Response regulator, receiver
THII_3043	COG3437	response regulator, receiver
THII_3044	COG1388	LysM domain
THII_3044	COG1470	cell adhesion involved in biofilm formation
THII_3049	COG1466	dna polymerase III delta subunit
THII_3051	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
THII_3052	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
THII_3052	COG0546	phosphoglycolate phosphatase activity
THII_3057	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
THII_3057	COG0662	Cupin 2, conserved barrel domain protein
THII_3059	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
THII_3060	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
THII_3063	COG0745	RESPONSE REGULATOR receiver
THII_3072	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
THII_3074	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
THII_3075	COG0488	(ABC) transporter
THII_3080	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
THII_3080	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
THII_3081	COG2104	thiamine diphosphate biosynthetic process
THII_3081	COG2022	thiamine diphosphate biosynthetic process
THII_3092	COG1331	Highly conserved protein containing a thioredoxin domain
THII_3093	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
THII_3094	COG2204	response regulator
THII_3095	COG3267	Type II secretory pathway component ExeA
THII_3095	COG3409	Peptidoglycan-binding domain 1 protein
THII_3097	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
THII_3098	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
THII_3099	COG0557	exoribonuclease II activity
THII_3102	COG4536	flavin adenine dinucleotide binding
THII_3107	COG0739	heme binding
THII_3113	COG0577	efflux transmembrane transporter activity
THII_3113	COG1136	(ABC) transporter
THII_3114	COG1136	(ABC) transporter
THII_3114	COG0577	efflux transmembrane transporter activity
THII_3120	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
THII_3121	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
THII_3123	COG0438	transferase activity, transferring glycosyl groups
THII_3128	COG0426	domain, Protein
THII_3129	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
THII_3133	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
THII_3134	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
THII_3138	COG0667	Aldo Keto reductase
THII_3139	COG4249	Peptidase C14 caspase catalytic subunit p20
THII_3139	COG2319	Wd-40 repeat
THII_3140	COG4249	Peptidase C14 caspase catalytic subunit p20
THII_3140	COG2319	Wd-40 repeat
THII_3147	COG3549	Plasmid maintenance system killer
THII_3151	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
THII_3153	COG0501	Belongs to the peptidase M48B family
THII_3154	COG4636	protein conserved in cyanobacteria
THII_3156	COG1562	ergosterol biosynthetic process
THII_3161	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
THII_3162	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
THII_3165	COG1138	Cytochrome C-type biogenesis protein
THII_3166	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
THII_3167	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
THII_3169	COG0840	transmembrane signaling receptor activity
THII_3173	COG1127	ABC transporter
THII_3177	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
THII_3177	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
THII_3186	COG1166	arginine decarboxylase activity
THII_3192	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
THII_3200	COG4658	electron transport chain
THII_3208	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
THII_3210	COG0840	transmembrane signaling receptor activity
THII_3211	COG4636	protein conserved in cyanobacteria
THII_3213	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
THII_3222	COG0439	Biotin carboxylase
THII_3223	COG0511	ligase activity, forming carbon-carbon bonds
THII_3224	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
THII_3225	COG2815	serine threonine protein kinase
THII_3225	COG0515	serine threonine protein kinase
THII_3228	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
THII_3232	COG2840	Smr protein MutS2
THII_3233	COG0181	hydroxymethylbilane synthase activity
THII_3240	COG3459	Glycosyltransferase 36 associated
THII_3247	COG3237	CsbD-like
THII_3251	COG3088	subunit of a heme lyase
THII_3258	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
THII_3261	COG0243	molybdopterin cofactor binding
THII_3262	COG0437	4 iron, 4 sulfur cluster binding
THII_3278	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
THII_3279	COG0850	regulation of cytokinetic process
THII_3280	COG2894	cell division
THII_3281	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
THII_3285	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
THII_3286	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
THII_3286	COG2813	Specifically methylates the guanine in position
THII_3287	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
THII_3288	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
THII_3289	COG3501	Rhs element vgr protein
THII_3297	COG2161	toxin-antitoxin pair type II binding
THII_3303	COG0450	alkyl hydroperoxide reductase
THII_3307	COG3246	L-lysine catabolic process to acetate
THII_3308	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
THII_3310	COG0583	DNA-binding transcription factor activity
THII_3311	COG1850	ribulose-bisphosphate carboxylase activity
THII_3315	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
THII_3316	COG2226	methyltransferase
THII_3321	COG0573	inorganic phosphate transmembrane transporter activity
THII_3323	COG0720	synthase
THII_3325	COG3094	Invasion gene expression up-regulator, SirB
THII_3330	COG0432	Pfam Uncharacterised protein family UPF0047
THII_3339	COG0469	pyruvate kinase activity
THII_3340	COG0126	phosphoglycerate kinase activity
THII_3341	COG0267	Belongs to the bacterial ribosomal protein bL33 family
THII_3345	COG2198	Histidine kinase
THII_3345	COG2205	protein histidine kinase activity
THII_3345	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
THII_3345	COG0784	Response regulator, receiver
THII_3347	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
THII_3350	COG1262	PFAM Formylglycine-generating sulfatase enzyme
THII_3351	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
THII_3361	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
THII_3362	COG0045	succinate-CoA ligase (ADP-forming) activity
THII_3363	COG0590	tRNA wobble adenosine to inosine editing
THII_3364	COG0124	histidyl-tRNA synthetase
THII_3365	COG2976	Protein conserved in bacteria
THII_3371	COG2132	Multicopper oxidase
THII_3372	COG2208	phosphoserine phosphatase activity
THII_3372	COG2770	Histidine kinase
THII_3379	COG2207	Transcriptional regulator
THII_3386	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
THII_3387	COG0077	Prephenate dehydratase
THII_3387	COG1605	Chorismate mutase
THII_3389	COG0590	tRNA wobble adenosine to inosine editing
THII_3391	COG0300	oxidoreductase activity
THII_3396	COG0436	Aminotransferase
THII_3402	COG0149	triose-phosphate isomerase activity
THII_3405	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
THII_3411	COG0194	GDP metabolic process
THII_3412	COG1561	YicC-like family, N-terminal region
THII_3413	COG0784	Response regulator, receiver
THII_3413	COG5002	protein histidine kinase activity
THII_3413	COG2198	Histidine kinase
THII_3415	COG3437	response regulator, receiver
THII_3417	COG5001	Diguanylate cyclase
THII_3420	COG1716	ATPase activity
THII_3420	COG0842	Transport permease protein
THII_3420	COG1131	(ABC) transporter
THII_3421	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
THII_3422	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
THII_3428	COG1530	ribonuclease E activity
THII_3429	COG0564	pseudouridine synthase activity
THII_3431	COG0616	signal peptide processing
THII_3431	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
THII_3433	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
THII_3434	COG1993	acr, cog1993
THII_3435	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
THII_3436	COG1993	acr, cog1993
THII_3437	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
THII_3444	COG0508	dehydrogenase complex catalyzes the overall conversion of
THII_3446	COG0039	L-malate dehydrogenase activity
THII_3447	COG0784	Response regulator, receiver
THII_3447	COG5002	protein histidine kinase activity
THII_3447	COG2198	Histidine kinase
THII_3449	COG0745	RESPONSE REGULATOR receiver
THII_3455	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
THII_3456	COG0305	Participates in initiation and elongation during chromosome replication
THII_3456	COG1372	Participates in initiation and elongation during chromosome replication
THII_3457	COG0359	binds to the 23S rRNA
THII_3458	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
THII_3459	COG0360	Binds together with S18 to 16S ribosomal RNA
THII_3461	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
THII_3462	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
THII_3463	COG0180	Tryptophanyl-tRNA synthetase
THII_3464	COG1994	Peptidase M50
THII_3465	COG0009	L-threonylcarbamoyladenylate synthase
THII_3466	COG0220	tRNA (guanine-N7-)-methyltransferase activity
THII_3468	COG2198	Histidine kinase
THII_3468	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
THII_3468	COG0784	Response regulator, receiver
THII_3468	COG2205	protein histidine kinase activity
THII_3470	COG0312	modulator of DNA gyrase
THII_3473	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
THII_3480	COG0156	8-amino-7-oxononanoate synthase activity
THII_3482	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
THII_3484	COG0442	prolyl-tRNA aminoacylation
THII_3485	COG4953	penicillin-binding protein 1C
THII_3487	COG0297	glycogen (starch) synthase activity
THII_3489	COG0859	PFAM glycosyl transferase family 9
THII_3491	COG0297	glycogen (starch) synthase activity
THII_3498	COG0508	dehydrogenase complex catalyzes the overall conversion of
THII_3509	COG2921	Belongs to the UPF0250 family
THII_3510	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
THII_3511	COG1686	Belongs to the peptidase S11 family
THII_3512	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
THII_3512	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
THII_3513	COG2951	lytic endotransglycosylase activity
THII_3514	COG0772	Belongs to the SEDS family
THII_3515	COG0768	penicillin binding
THII_3516	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
THII_3517	COG1792	Involved in formation and maintenance of cell shape
THII_3518	COG1077	Cell shape determining protein MreB Mrl
THII_3520	COG0154	amidase activity
THII_3521	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
THII_3527	COG0717	Belongs to the dCTP deaminase family
THII_3528	COG0489	protein tyrosine kinase activity
THII_3529	COG0517	IMP dehydrogenase activity
THII_3532	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
THII_3537	COG2321	neutral zinc metallopeptidase
THII_3542	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
THII_3543	COG0298	carbon dioxide binding
THII_3544	COG0375	protein maturation
THII_3546	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
THII_3547	COG0142	geranyltranstransferase activity
THII_3549	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
THII_3552	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
THII_3562	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
THII_3566	COG0842	Transport permease protein
THII_3567	COG1131	(ABC) transporter
THII_3570	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
THII_3571	COG1672	PFAM Archaeal ATPase
THII_3571	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
THII_3575	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
THII_3577	COG0367	asparagine synthase
THII_3580	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
THII_3582	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
THII_3583	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
THII_3584	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
THII_3585	COG1028	Short-chain dehydrogenase reductase Sdr
THII_3587	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
THII_3588	COG0416	fatty acid biosynthetic process
THII_3589	COG0333	Belongs to the bacterial ribosomal protein bL32 family
THII_3590	COG1399	metal-binding, possibly nucleic acid-binding protein
THII_3591	COG0424	maF-like protein
THII_3592	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
THII_3595	COG2217	Heavy metal translocating P-type atpase
THII_3596	COG2084	Dehydrogenase
THII_3597	COG0210	DNA helicase
THII_3598	COG0531	amino acid
THII_3603	COG3501	Rhs element vgr protein
THII_3610	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
THII_3612	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
THII_3613	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
THII_3614	COG0784	Response regulator, receiver
THII_3614	COG2205	protein histidine kinase activity
THII_3615	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
THII_3616	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
THII_3617	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
THII_3621	COG0840	transmembrane signaling receptor activity
THII_3623	COG0134	indole-3-glycerol-phosphate synthase activity
THII_3624	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
THII_3625	COG0471	metal ion transport
THII_3625	COG3273	potassium ion transport
THII_3628	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
THII_3629	COG0484	heat shock protein binding
THII_3630	COG0148	phosphopyruvate hydratase activity
THII_3631	COG2877	3-deoxy-8-phosphooctulonate synthase activity
THII_3633	COG0693	protein deglycase activity
THII_3639	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
THII_3642	COG2234	aminopeptidase activity
THII_3648	COG0784	Response regulator, receiver
THII_3648	COG2205	protein histidine kinase activity
THII_3656	COG0589	response to stress
THII_3658	COG0501	Belongs to the peptidase M48B family
THII_3660	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
THII_3660	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
THII_3661	COG0802	atpase or kinase
THII_3665	COG1196	nuclear chromosome segregation
THII_3665	COG0741	lytic transglycosylase activity
THII_3665	COG0739	heme binding
THII_3672	COG3293	Transposase
THII_3675	COG0409	Hydrogenase expression formation protein
THII_3677	COG0628	permease
THII_3682	COG4999	Histidine kinase
THII_3682	COG3850	Histidine kinase
THII_3682	COG3437	response regulator, receiver
THII_3682	COG2205	protein histidine kinase activity
THII_3690	COG0493	'glutamate synthase
THII_3692	COG1013	pyruvate-flavodoxin oxidoreductase activity
THII_3693	COG0674	pyruvate-flavodoxin oxidoreductase activity
THII_3701	COG0546	phosphoglycolate phosphatase activity
THII_3702	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
THII_3705	COG0754	glutathionylspermidine amidase activity
THII_3706	COG0724	RNA recognition motif
THII_3708	COG0635	Involved in the biosynthesis of porphyrin-containing compound
THII_3712	COG0248	Ppx GppA phosphatase
THII_3715	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
THII_3716	COG0019	diaminopimelate decarboxylase activity
THII_3719	COG2192	nodulation
THII_3724	COG0167	dihydroorotate dehydrogenase activity
THII_3725	COG2183	response to ionizing radiation
THII_3728	COG0070	glutamate synthase
THII_3728	COG0069	glutamate synthase activity
THII_3728	COG0067	glutamate synthase
THII_3733	COG3549	Plasmid maintenance system killer
THII_3734	COG2205	protein histidine kinase activity
THII_3734	COG0784	Response regulator, receiver
THII_3737	COG0518	GMP synthase (glutamine-hydrolyzing) activity
THII_3737	COG0519	Catalyzes the synthesis of GMP from XMP
THII_3739	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
THII_3756	COG3335	DDE superfamily endonuclease
THII_3761	COG0556	nucleotide-excision repair
THII_3765	COG0445	tRNA wobble uridine modification
THII_3766	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
THII_3767	COG1573	uracil-dna glycosylase
THII_3773	COG2195	Cleaves the N-terminal amino acid of tripeptides
THII_3778	COG1404	Belongs to the peptidase S8 family
THII_3779	COG0588	phosphoglycerate mutase activity
THII_3780	COG4942	peptidase
THII_3781	COG0793	Belongs to the peptidase S41A family
THII_3782	COG0693	protein deglycase activity
THII_3783	COG0372	Belongs to the citrate synthase family
THII_3790	COG2815	serine threonine protein kinase
THII_3790	COG0515	serine threonine protein kinase
THII_3792	COG0784	Response regulator, receiver
THII_3792	COG3437	response regulator, receiver
THII_3793	COG3706	GGDEF domain
THII_3793	COG4251	negative regulation of phosphorylation
THII_3793	COG5001	Diguanylate cyclase
THII_3793	COG2203	Gaf domain
THII_3801	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
THII_3802	COG2852	Protein conserved in bacteria
THII_3806	COG0475	glutathione-regulated potassium exporter activity
THII_3807	COG2154	pterin-4-alpha-carbinolamine dehydratase
THII_3809	COG1797	cobyrinic acid a,c-diamide synthase activity
THII_3810	COG2885	chlorophyll binding
THII_3816	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
THII_3817	COG3162	membrane
THII_3822	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
THII_3827	COG1324	tolerance protein
THII_3828	COG4232	protein-disulfide reductase activity
THII_3829	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
THII_3834	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
THII_3834	COG2205	protein histidine kinase activity
THII_3835	COG2205	protein histidine kinase activity
THII_3835	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
THII_3836	COG1528	Iron-storage protein
THII_3837	COG3830	Belongs to the UPF0237 family
THII_3838	COG0242	peptide deformylase activity
THII_3850	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
THII_3857	COG0745	RESPONSE REGULATOR receiver
THII_3858	COG1053	succinate dehydrogenase
THII_3860	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
THII_3861	COG0739	heme binding
THII_3861	COG0741	lytic transglycosylase activity
THII_3861	COG1196	nuclear chromosome segregation
THII_3864	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
THII_3867	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
THII_3869	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
THII_3870	COG1530	ribonuclease E activity
THII_3872	COG2204	response regulator
THII_3873	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
THII_3879	COG0228	four-way junction DNA binding
THII_3880	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
THII_3882	COG0335	large ribosomal subunit rRNA binding
THII_3891	COG0330	HflC and HflK could
THII_3892	COG0653	protein targeting
THII_3895	COG0456	acetyltransferase
THII_3896	COG1573	uracil-dna glycosylase
THII_3897	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
THII_3898	COG1765	OsmC-like protein
THII_3899	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
THII_3900	COG1234	tRNA 3'-trailer cleavage
THII_3904	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
THII_3905	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
THII_3905	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
THII_3906	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
THII_3910	COG4172	Belongs to the ABC transporter superfamily
THII_3912	COG1560	Kdo2-lipid A biosynthetic process
THII_3915	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
THII_3926	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
THII_3937	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
THII_3938	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
THII_3941	COG0137	argininosuccinate synthase activity
THII_3944	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
THII_3945	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
THII_3947	COG3023	N-Acetylmuramoyl-L-alanine amidase
THII_3950	COG1842	Phage shock protein A