locus-tag	class	description
AKN87_00010	COG1286	toxin biosynthetic process
AKN87_00025	COG2925	Exonuclease
AKN87_00040	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AKN87_00045	COG0544	peptidyl-prolyl cis-trans isomerase activity
AKN87_00055	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
AKN87_00060	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
AKN87_00070	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
AKN87_00075	COG3089	Belongs to the UPF0270 family
AKN87_00080	COG0431	NADPH-dependent FMN reductase
AKN87_00085	COG2056	Na+-H+ antiporter family
AKN87_00090	COG2837	iron assimilation
AKN87_00095	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
AKN87_00105	COG2914	Belongs to the UPF0125 (RnfH) family
AKN87_00110	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
AKN87_00120	COG2326	polyphosphate kinase activity
AKN87_00125	COG3081	Nucleoid-associated protein
AKN87_00140	COG3171	Protein conserved in bacteria
AKN87_00150	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AKN87_00170	COG2610	gluconate transmembrane transporter activity
AKN87_00180	COG2084	Dehydrogenase
AKN87_00185	COG3622	Belongs to the hyi family
AKN87_00205	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
AKN87_00210	COG0352	thiamine-phosphate diphosphorylase activity
AKN87_00230	COG0495	leucyl-tRNA aminoacylation
AKN87_00240	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AKN87_00240	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
AKN87_00250	COG1196	nuclear chromosome segregation
AKN87_00255	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
AKN87_00260	COG1546	Belongs to the CinA family
AKN87_00270	COG2137	regulation of response to DNA damage stimulus
AKN87_00285	COG0513	Belongs to the DEAD box helicase family
AKN87_00290	COG1946	Acyl-CoA thioesterase
AKN87_00325	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
AKN87_00330	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
AKN87_00335	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
AKN87_00340	COG0772	Belongs to the SEDS family
AKN87_00350	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
AKN87_00355	COG1181	Belongs to the D-alanine--D-alanine ligase family
AKN87_00370	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
AKN87_00375	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
AKN87_00385	COG0653	protein targeting
AKN87_00395	COG0494	nUDIX hydrolase
AKN87_00400	COG2096	Adenosyltransferase
AKN87_00410	COG1666	GTP binding
AKN87_00415	COG0322	excinuclease ABC activity
AKN87_00425	COG0557	exoribonuclease II activity
AKN87_00430	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AKN87_00435	COG0360	Binds together with S18 to 16S ribosomal RNA
AKN87_00450	COG0359	binds to the 23S rRNA
AKN87_00455	COG0305	Participates in initiation and elongation during chromosome replication
AKN87_00475	COG0138	bifunctional purine biosynthesis protein purh
AKN87_00505	COG2135	peptidase activity
AKN87_00515	COG1660	Displays ATPase and GTPase activities
AKN87_00530	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
AKN87_00555	COG3201	nicotinamide mononucleotide transporter
AKN87_00565	COG1846	Transcriptional regulator
AKN87_00575	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
AKN87_00590	COG1805	sodium ion transport
AKN87_00615	COG1477	protein flavinylation
AKN87_00625	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AKN87_00635	COG4591	ABC-type transport system involved in lipoprotein release permease component
AKN87_00650	COG0436	Aminotransferase
AKN87_00655	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AKN87_00665	COG4536	flavin adenine dinucleotide binding
AKN87_00675	COG1399	metal-binding, possibly nucleic acid-binding protein
AKN87_00680	COG0333	Belongs to the bacterial ribosomal protein bL32 family
AKN87_00685	COG0416	fatty acid biosynthetic process
AKN87_00700	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
AKN87_00705	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
AKN87_00710	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
AKN87_00715	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
AKN87_00720	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
AKN87_00735	COG0084	hydrolase, TatD family'
AKN87_00740	COG1643	Atp-dependent helicase
AKN87_00745	COG0826	peptidase U32
AKN87_00755	COG1214	PFAM Peptidase M22, glycoprotease
AKN87_00760	COG0742	ribosomal rna small subunit methyltransferase
AKN87_00780	COG0564	pseudouridine synthase activity
AKN87_00795	COG3720	iron ion transport
AKN87_00805	COG0848	biopolymer transport protein
AKN87_00810	COG4558	Periplasmic binding protein
AKN87_00815	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AKN87_00820	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
AKN87_00840	COG0165	Argininosuccinate lyase
AKN87_00855	COG0530	calcium, potassium:sodium antiporter activity
AKN87_00860	COG0471	metal ion transport
AKN87_00865	COG0513	Belongs to the DEAD box helicase family
AKN87_00885	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
AKN87_00900	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
AKN87_00950	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AKN87_00965	COG1968	undecaprenyl-diphosphatase activity
AKN87_00995	COG0542	response to heat
AKN87_01000	COG0586	Pfam SNARE associated Golgi protein
AKN87_01005	COG2094	Belongs to the DNA glycosylase MPG family
AKN87_01010	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
AKN87_01015	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
AKN87_01030	COG0768	penicillin binding
AKN87_01035	COG0772	Belongs to the SEDS family
AKN87_01040	COG2951	lytic endotransglycosylase activity
AKN87_01050	COG1686	Belongs to the peptidase S11 family
AKN87_01060	COG0321	lipoyl(octanoyl) transferase activity
AKN87_01065	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
AKN87_01075	COG2264	protein methyltransferase activity
AKN87_01105	COG0514	ATP-dependent DNA helicase (RecQ)
AKN87_01110	COG2076	Multidrug Resistance protein
AKN87_01120	COG5592	hemerythrin HHE cation binding domain
AKN87_01125	COG0602	queuosine metabolic process
AKN87_01130	COG0720	synthase
AKN87_01150	COG2823	Periplasmic or secreted lipoprotein
AKN87_01155	COG0363	glucosamine-6-phosphate deaminase activity
AKN87_01170	COG2967	ApaG domain
AKN87_01175	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
AKN87_01180	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AKN87_01190	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
AKN87_01200	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
AKN87_01210	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
AKN87_01215	COG0795	lipopolysaccharide-transporting ATPase activity
AKN87_01220	COG0795	lipopolysaccharide-transporting ATPase activity
AKN87_01225	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
AKN87_01230	COG2027	D-alanyl-D-alanine carboxypeptidase
AKN87_01240	COG2847	Copper chaperone PCu(A)C
AKN87_01265	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
AKN87_01270	COG0542	response to heat
AKN87_01285	COG2030	dehydratase
AKN87_01290	COG0318	PFAM AMP-dependent synthetase and ligase
AKN87_01295	COG0589	response to stress
AKN87_01300	COG1252	NADH dehydrogenase
AKN87_01310	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
AKN87_01320	COG0148	phosphopyruvate hydratase activity
AKN87_01325	COG2877	3-deoxy-8-phosphooctulonate synthase activity
AKN87_01330	COG0504	CTP synthase activity
AKN87_01355	COG1199	ATP-dependent helicase activity
AKN87_01365	COG0167	dihydroorotate dehydrogenase activity
AKN87_01370	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AKN87_01380	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AKN87_01390	COG3243	poly(R)-hydroxyalkanoic acid synthase
AKN87_01400	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
AKN87_01415	COG0800	Aldolase
AKN87_01430	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
AKN87_01435	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
AKN87_01440	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
AKN87_01455	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
AKN87_01460	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
AKN87_01475	COG2989	Protein conserved in bacteria
AKN87_01480	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
AKN87_01490	COG0291	Belongs to the bacterial ribosomal protein bL35 family
AKN87_01495	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
AKN87_01500	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
AKN87_01505	COG0072	phenylalanine-tRNA ligase activity
AKN87_01510	COG0776	regulation of translation
AKN87_01545	COG0693	protein deglycase activity
AKN87_01555	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
AKN87_01580	COG1262	PFAM Formylglycine-generating sulfatase enzyme
AKN87_01580	COG0515	serine threonine protein kinase
AKN87_01630	COG0582	viral genome integration into host DNA
AKN87_01680	COG2076	Multidrug Resistance protein
AKN87_01700	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
AKN87_01815	COG0740	serine-type endopeptidase activity
AKN87_01915	COG0542	response to heat
AKN87_01925	COG0189	ligase activity
AKN87_01940	COG2223	nitrite transmembrane transporter activity
AKN87_01960	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
AKN87_01970	COG2321	neutral zinc metallopeptidase
AKN87_01975	COG4988	ABC transporter
AKN87_01980	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
AKN87_01990	COG0328	RNA-DNA hybrid ribonuclease activity
AKN87_01995	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
AKN87_02060	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
AKN87_02070	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
AKN87_02075	COG1115	amino acid carrier protein
AKN87_02095	COG0425	Belongs to the sulfur carrier protein TusA family
AKN87_02100	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
AKN87_02105	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
AKN87_02125	COG0308	aminopeptidase N
AKN87_02140	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
AKN87_02155	COG1335	isochorismatase
AKN87_02160	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
AKN87_02165	COG4181	ATPase activity
AKN87_02180	COG0402	S-adenosylhomocysteine deaminase activity
AKN87_02220	COG0418	dihydroorotase activity
AKN87_02225	COG0137	argininosuccinate synthase activity
AKN87_02230	COG0346	lactoylglutathione lyase activity
AKN87_02245	COG1028	Short-chain dehydrogenase reductase Sdr
AKN87_02255	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
AKN87_02260	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
AKN87_02265	COG2252	PERMEase
AKN87_02280	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
AKN87_02285	COG0066	3-isopropylmalate dehydratase activity
AKN87_02310	COG0668	transmembrane transport
AKN87_02315	COG4133	protoheme IX ABC transporter activity
AKN87_02340	COG1138	Cytochrome C-type biogenesis protein
AKN87_02360	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
AKN87_02365	COG1360	Flagellar Motor Protein
AKN87_02380	COG3133	Outer membrane lipoprotein
AKN87_02425	COG1025	Belongs to the peptidase M16 family
AKN87_02455	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
AKN87_02495	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
AKN87_02500	COG1074	ATP-dependent DNA helicase activity
AKN87_02505	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
AKN87_02510	COG0393	Putative heavy-metal-binding
AKN87_02520	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
AKN87_02545	COG1024	Enoyl-CoA hydratase
AKN87_02560	COG2204	response regulator
AKN87_02565	COG4191	Histidine kinase
AKN87_02565	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AKN87_02595	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AKN87_02600	COG0481	GTPase activity
AKN87_02610	COG0571	ribonuclease III activity
AKN87_02615	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
AKN87_02620	COG1381	Involved in DNA repair and RecF pathway recombination
AKN87_02625	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
AKN87_02645	COG1131	(ABC) transporter
AKN87_02650	COG0842	Transport permease protein
AKN87_02655	COG0791	NLP P60 protein
AKN87_02660	COG0791	NLP P60 protein
AKN87_02665	COG0133	tryptophan synthase activity
AKN87_02675	COG0642	Histidine kinase
AKN87_02685	COG0745	RESPONSE REGULATOR receiver
AKN87_02690	COG2350	Protein conserved in bacteria
AKN87_02695	COG2917	probably involved in intracellular septation
AKN87_02700	COG0613	PHP domain protein
AKN87_02705	COG0009	L-threonylcarbamoyladenylate synthase
AKN87_02710	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
AKN87_02715	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
AKN87_02725	COG0535	radical SAM domain protein
AKN87_02735	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
AKN87_02810	COG1397	ADP-ribosylglycohydrolase
AKN87_02815	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
AKN87_02825	COG0419	ATPase involved in DNA repair
AKN87_02830	COG0420	3'-5' exonuclease activity
AKN87_02840	COG0628	permease
AKN87_02850	COG0625	glutathione transferase activity
AKN87_02870	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
AKN87_02880	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
AKN87_02890	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AKN87_02895	COG2814	Major facilitator Superfamily
AKN87_02915	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
AKN87_02920	COG0585	pseudouridine synthase activity
AKN87_02925	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
AKN87_02935	COG2911	Protein conserved in bacteria
AKN87_02940	COG0729	surface antigen
AKN87_02945	COG0708	Exodeoxyribonuclease III
AKN87_02950	COG3781	membrane
AKN87_02955	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
AKN87_02960	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
AKN87_03185	COG2801	Transposase and inactivated derivatives
AKN87_03190	COG2963	transposase activity
AKN87_03220	COG0037	tRNA processing
AKN87_03240	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
AKN87_03250	COG0560	Phosphoserine phosphatase
AKN87_03270	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AKN87_03285	COG4953	penicillin-binding protein 1C
AKN87_03295	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
AKN87_03300	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
AKN87_03305	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
AKN87_03310	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
AKN87_03315	COG5007	Belongs to the BolA IbaG family
AKN87_03335	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
AKN87_03340	COG1127	ABC transporter
AKN87_03350	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
AKN87_03360	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
AKN87_03365	COG1137	ATPase activity
AKN87_03380	COG1132	(ABC) transporter
AKN87_03405	COG0730	response to heat
AKN87_03420	COG1024	Enoyl-CoA hydratase
AKN87_03425	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
AKN87_03435	COG2010	Cytochrome c
AKN87_03440	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
AKN87_03440	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AKN87_03445	COG0023	Translation Initiation Factor
AKN87_03450	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AKN87_03455	COG0069	glutamate synthase activity
AKN87_03460	COG2119	membrane
AKN87_03465	COG5394	Polyhydroxyalkanoate synthesis repressor PhaR
AKN87_03470	COG0675	Transposase, IS605 OrfB family
AKN87_03495	COG1335	isochorismatase
AKN87_03555	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AKN87_03560	COG2373	Large extracellular alpha-helical protein
AKN87_03575	COG0433	COG0433 Predicted ATPase
AKN87_03580	COG0788	formyltetrahydrofolate deformylase activity
AKN87_03585	COG2853	Lipoprotein
AKN87_03590	COG0215	cysteine-tRNA ligase activity
AKN87_03595	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AKN87_03600	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
AKN87_03605	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AKN87_03610	COG2031	fatty acid transporter
AKN87_03615	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
AKN87_03620	COG3115	cell septum assembly
AKN87_03625	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
AKN87_03630	COG2824	Alkylphosphonate utilization operon protein PhnA
AKN87_03640	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
AKN87_03645	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
AKN87_03650	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
AKN87_03655	COG1605	Chorismate mutase
AKN87_03655	COG0077	Prephenate dehydratase
AKN87_03670	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
AKN87_03675	COG1132	(ABC) transporter
AKN87_03695	COG0271	Belongs to the BolA IbaG family
AKN87_03725	COG0848	biopolymer transport protein
AKN87_03730	COG0811	peptide transport
AKN87_03735	COG0811	peptide transport
AKN87_03745	COG0121	glutamine amidotransferase
AKN87_03755	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
AKN87_03775	COG3344	reverse transcriptase
AKN87_03780	COG3344	reverse transcriptase
AKN87_03805	COG0730	response to heat
AKN87_03810	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
AKN87_03815	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
AKN87_03825	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
AKN87_03830	COG4208	sulfate ABC transporter
AKN87_03840	COG0469	pyruvate kinase activity
AKN87_03845	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
AKN87_03850	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
AKN87_03855	COG3842	ATPase activity
AKN87_03875	COG2885	chlorophyll binding
AKN87_03885	COG0427	acetyl-CoA hydrolase
AKN87_03910	COG0513	Belongs to the DEAD box helicase family
AKN87_03925	COG2212	antiporter activity
AKN87_03935	COG0651	ATP synthesis coupled electron transport
AKN87_03940	COG1006	Multisubunit Na H antiporter MnhC subunit
AKN87_03945	COG2111	Na H antiporter
AKN87_03945	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
AKN87_03950	COG0604	alcohol dehydrogenase
AKN87_03965	COG0556	nucleotide-excision repair
AKN87_03975	COG1136	(ABC) transporter
AKN87_03990	COG2996	Protein conserved in bacteria
AKN87_04000	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AKN87_04005	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AKN87_04010	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
AKN87_04015	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AKN87_04025	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
AKN87_04035	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
AKN87_04045	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
AKN87_04050	COG0233	cytoplasmic translational termination
AKN87_04055	COG0528	UMP kinase activity
AKN87_04060	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
AKN87_04065	COG0052	Belongs to the universal ribosomal protein uS2 family
AKN87_04070	COG0024	Methionine aminopeptidase
AKN87_04075	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
AKN87_04080	COG1393	Belongs to the ArsC family
AKN87_04085	COG2171	N-acyltransferase activity
AKN87_04090	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
AKN87_04095	COG2166	iron-sulfur cluster assembly
AKN87_04130	COG2814	Major facilitator Superfamily
AKN87_04140	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
AKN87_04145	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
AKN87_04155	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
AKN87_04160	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
AKN87_04170	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
AKN87_04175	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
AKN87_04190	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
AKN87_04205	COG0604	alcohol dehydrogenase
AKN87_04210	COG0616	signal peptide processing
AKN87_04235	COG0812	UDP-N-acetylmuramate dehydrogenase activity
AKN87_04240	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
AKN87_04245	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
AKN87_04250	COG2835	tetraacyldisaccharide 4'-kinase activity
AKN87_04255	COG1663	tetraacyldisaccharide 4'-kinase activity
AKN87_04260	COG2333	competence protein COMEC
AKN87_04260	COG0658	competence protein
AKN87_04270	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
AKN87_04280	COG0511	ligase activity, forming carbon-carbon bonds
AKN87_04280	COG5016	pyruvate
AKN87_04290	COG2239	Acts as a magnesium transporter
AKN87_04320	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
AKN87_04330	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
AKN87_04340	COG0037	tRNA processing
AKN87_04345	COG2814	Major facilitator Superfamily
AKN87_04350	COG0284	orotidine-5'-phosphate decarboxylase activity
AKN87_04355	COG0114	fumarate hydratase activity
AKN87_04385	COG1862	Preprotein translocase
AKN87_04395	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
AKN87_04405	COG2259	Doxx family
AKN87_04410	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
AKN87_04415	COG2366	antibiotic biosynthetic process
AKN87_04420	COG2885	chlorophyll binding
AKN87_04435	COG0400	carboxylic ester hydrolase activity
AKN87_04440	COG0513	Belongs to the DEAD box helicase family
AKN87_04445	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
AKN87_04455	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AKN87_04465	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
AKN87_04470	COG0425	Belongs to the sulfur carrier protein TusA family
AKN87_04475	COG4783	chaperone-mediated protein folding
AKN87_04485	COG2814	Major facilitator Superfamily
AKN87_04490	COG2356	endonuclease I
AKN87_04500	COG1272	protein, Hemolysin III
AKN87_04515	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
AKN87_04520	COG0492	ferredoxin-NADP+ reductase activity
AKN87_04525	COG0456	acetyltransferase
AKN87_04545	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
AKN87_04550	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AKN87_04555	COG1120	ATPase activity
AKN87_04565	COG1492	cobalamin metabolic process
AKN87_04570	COG0778	Nitroreductase
AKN87_04605	COG0583	DNA-binding transcription factor activity
AKN87_04645	COG0318	PFAM AMP-dependent synthetase and ligase
AKN87_04650	COG1960	acyl-CoA dehydrogenase activity
AKN87_04655	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
AKN87_04660	COG1024	Enoyl-CoA hydratase
AKN87_04660	COG1250	3-hydroxyacyl-CoA dehydrogenase
AKN87_04685	COG0789	Transcriptional regulator
AKN87_04690	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
AKN87_04715	COG0045	succinate-CoA ligase (ADP-forming) activity
AKN87_04735	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
AKN87_04750	COG2009	succinate dehydrogenase
AKN87_04770	COG2084	Dehydrogenase
AKN87_04780	COG3278	Belongs to the heme-copper respiratory oxidase family
AKN87_04795	COG2010	Cytochrome c
AKN87_04810	COG2217	Heavy metal translocating P-type atpase
AKN87_04830	COG0741	lytic transglycosylase activity
AKN87_04835	COG2175	clavaminate synthase activity
AKN87_04840	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AKN87_04845	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
AKN87_04850	COG4521	taurine ABC transporter
AKN87_04855	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
AKN87_04860	COG0492	ferredoxin-NADP+ reductase activity
AKN87_04880	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AKN87_04900	COG0776	regulation of translation
AKN87_04905	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
AKN87_04905	COG0316	Belongs to the HesB IscA family
AKN87_04910	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
AKN87_04930	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
AKN87_04935	COG2840	Smr protein MutS2
AKN87_04965	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
AKN87_04970	COG0018	arginyl-trna synthetase
AKN87_04985	COG4206	TonB-dependent receptor
AKN87_04995	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
AKN87_05005	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
AKN87_05015	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
AKN87_05015	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
AKN87_05020	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
AKN87_05030	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
AKN87_05040	COG1070	Carbohydrate kinase
AKN87_05045	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
AKN87_05055	COG2207	Transcriptional regulator
AKN87_05090	COG0183	Belongs to the thiolase family
AKN87_05095	COG1250	3-hydroxyacyl-CoA dehydrogenase
AKN87_05095	COG1024	Enoyl-CoA hydratase
AKN87_05100	COG0589	response to stress
AKN87_05105	COG0405	Gamma-glutamyltransferase
AKN87_05110	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
AKN87_05115	COG0488	(ABC) transporter
AKN87_05130	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
AKN87_05135	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
AKN87_05145	COG0741	lytic transglycosylase activity
AKN87_05145	COG1388	LysM domain
AKN87_05155	COG4166	transmembrane transport
AKN87_05160	COG4174	ABC transporter (Permease)
AKN87_05165	COG4239	(ABC) transporter, permease
AKN87_05170	COG4172	Belongs to the ABC transporter superfamily
AKN87_05190	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
AKN87_05215	COG0753	catalase activity
AKN87_05220	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
AKN87_05225	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
AKN87_05230	COG0482	sulfurtransferase activity
AKN87_05235	COG2915	High frequency lysogenization protein hflD homolog
AKN87_05240	COG0697	spore germination
AKN87_05250	COG2850	peptidyl-arginine hydroxylation
AKN87_05255	COG2153	protein acetylation
AKN87_05275	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
AKN87_05285	COG2226	methyltransferase
AKN87_05300	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
AKN87_05315	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
AKN87_05320	COG2860	membrane
AKN87_05325	COG0644	oxidoreductase
AKN87_05365	COG1132	(ABC) transporter
AKN87_05370	COG3284	Transcriptional regulator
AKN87_05405	COG0435	Glutathione S-transferase
AKN87_05415	COG1522	sequence-specific DNA binding
AKN87_05425	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
AKN87_05435	COG1294	oxidase, subunit
AKN87_05445	COG3162	membrane
AKN87_05450	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AKN87_05455	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
AKN87_05460	COG1570	exodeoxyribonuclease VII activity
AKN87_05465	COG4942	peptidase
AKN87_05470	COG0668	transmembrane transport
AKN87_05485	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AKN87_05490	COG2900	Belongs to the SlyX family
AKN87_05505	COG0442	prolyl-tRNA aminoacylation
AKN87_05510	COG0786	glutamate:sodium symporter activity
AKN87_05520	COG1024	Enoyl-CoA hydratase
AKN87_05525	COG0183	Belongs to the thiolase family
AKN87_05535	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AKN87_05545	COG0583	DNA-binding transcription factor activity
AKN87_05560	COG1024	Enoyl-CoA hydratase
AKN87_05565	COG1960	acyl-CoA dehydrogenase activity
AKN87_05570	COG0459	protein refolding
AKN87_05575	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
AKN87_05580	COG3030	protein affecting phage T7 exclusion by the F plasmid
AKN87_05585	COG2211	Major facilitator Superfamily
AKN87_05675	COG0582	viral genome integration into host DNA
AKN87_05690	COG2969	positive regulation of protein catabolic process
AKN87_05695	COG0625	glutathione transferase activity
AKN87_05700	COG2857	Cytochrome c1
AKN87_05705	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
AKN87_05710	COG0723	plastoquinol--plastocyanin reductase activity
AKN87_05715	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
AKN87_05720	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
AKN87_05725	COG0659	secondary active sulfate transmembrane transporter activity
AKN87_05730	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
AKN87_05735	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
AKN87_05745	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
AKN87_05750	COG1538	Outer membrane efflux protein
AKN87_05755	COG1702	phosphate starvation-inducible protein PhoH
AKN87_05770	COG0815	Transfers the fatty acyl group on membrane lipoproteins
AKN87_05790	COG1011	Hydrolase
AKN87_05820	COG1965	Belongs to the frataxin family
AKN87_05825	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
AKN87_05830	COG3118	belongs to the thioredoxin family
AKN87_05840	COG0617	tRNA 3'-terminal CCA addition
AKN87_05850	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
AKN87_05855	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
AKN87_05865	COG0166	Belongs to the GPI family
AKN87_05885	COG1362	aminopeptidase activity
AKN87_05890	COG1671	Belongs to the UPF0178 family
AKN87_05900	COG0436	Aminotransferase
AKN87_05910	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
AKN87_05925	COG0545	Peptidyl-prolyl cis-trans isomerase
AKN87_05935	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
AKN87_05955	COG0860	N-Acetylmuramoyl-L-alanine amidase
AKN87_05960	COG0802	atpase or kinase
AKN87_05970	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
AKN87_05975	COG1162	GTPase activity
AKN87_05980	COG0688	phosphatidylethanolamine metabolic process
AKN87_06005	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
AKN87_06015	COG2226	methyltransferase
AKN87_06025	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
AKN87_06030	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
AKN87_06040	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
AKN87_06045	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
AKN87_06060	COG0789	Transcriptional regulator
AKN87_06070	COG1067	ATP-dependent peptidase activity
AKN87_06085	COG1136	(ABC) transporter
AKN87_06100	COG0778	Nitroreductase
AKN87_06105	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
AKN87_06110	COG0534	Mate efflux family protein
AKN87_06115	COG3118	belongs to the thioredoxin family
AKN87_06120	COG2813	Specifically methylates the guanine in position
AKN87_06130	COG3313	Fe-S protein
AKN87_06135	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
AKN87_06140	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
AKN87_06145	COG0633	Ferredoxin
AKN87_06155	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
AKN87_06160	COG4221	oxidoreductase activity
AKN87_06160	COG3321	synthase
AKN87_06160	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
AKN87_06160	COG0604	alcohol dehydrogenase
AKN87_06165	COG0793	Belongs to the peptidase S41A family
AKN87_06185	COG0545	Peptidyl-prolyl cis-trans isomerase
AKN87_06210	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
AKN87_06220	COG0330	HflC and HflK could
AKN87_06225	COG0330	HflC and HflK could
AKN87_06230	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
AKN87_06235	COG1923	regulation of RNA biosynthetic process
AKN87_06255	COG1028	Short-chain dehydrogenase reductase Sdr
AKN87_06260	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
AKN87_06260	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
AKN87_06265	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
AKN87_06270	COG3258	Cytochrome c
AKN87_06280	COG0814	amino acid
AKN87_06285	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
AKN87_06290	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
AKN87_06320	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
AKN87_06325	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
AKN87_06330	COG0211	Belongs to the bacterial ribosomal protein bL27 family
AKN87_06335	COG0261	This protein binds to 23S rRNA in the presence of protein L20
AKN87_06340	COG0142	geranyltranstransferase activity
AKN87_06345	COG1970	mechanosensitive ion channel activity
AKN87_06350	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
AKN87_06360	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
AKN87_06365	COG2885	chlorophyll binding
AKN87_06390	COG0824	Thioesterase
AKN87_06395	COG2255	four-way junction helicase activity
AKN87_06400	COG0632	four-way junction helicase activity
AKN87_06405	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
AKN87_06415	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
AKN87_06425	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
AKN87_06435	COG0525	valine-tRNA ligase activity
AKN87_06445	COG4120	Belongs to the binding-protein-dependent transport system permease family
AKN87_06450	COG1122	ATPase activity
AKN87_06455	COG0490	domain, Protein
AKN87_06455	COG0471	metal ion transport
AKN87_06460	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
AKN87_06470	COG0237	dephospho-CoA kinase activity
AKN87_06475	COG0134	indole-3-glycerol-phosphate synthase activity
AKN87_06480	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
AKN87_06500	COG0546	phosphoglycolate phosphatase activity
AKN87_06505	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
AKN87_06535	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
AKN87_06540	COG0456	acetyltransferase
AKN87_06550	COG1722	exodeoxyribonuclease VII activity
AKN87_06555	COG0142	geranyltranstransferase activity
AKN87_06580	COG3530	Putative quorum-sensing-regulated virulence factor
AKN87_06585	COG0513	Belongs to the DEAD box helicase family
AKN87_06590	COG1509	lysine 2,3-aminomutase activity
AKN87_06595	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
AKN87_06615	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AKN87_06635	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
AKN87_06645	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
AKN87_06650	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
AKN87_06655	COG3178	'Phosphotransferase
AKN87_06660	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
AKN87_06665	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
AKN87_06670	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
AKN87_06680	COG0842	Transport permease protein
AKN87_06685	COG1129	ABC transporter
AKN87_06685	COG0842	Transport permease protein
AKN87_06690	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AKN87_06695	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
AKN87_06710	COG3079	Belongs to the UPF0149 family
AKN87_06715	COG0006	proline dipeptidase activity
AKN87_06720	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AKN87_06730	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AKN87_06755	COG0560	Phosphoserine phosphatase
AKN87_06755	COG3830	Belongs to the UPF0237 family
AKN87_06765	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
AKN87_06765	COG3008	intermembrane lipid transfer
AKN87_06775	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
AKN87_06795	COG3150	esterase
AKN87_06825	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
AKN87_06835	COG0204	Acyl-transferase
AKN87_06850	COG3098	single-species biofilm formation
AKN87_06870	COG0494	nUDIX hydrolase
AKN87_06880	COG1217	gtp-binding protein TYPA
AKN87_06885	COG0301	tRNA thio-modification
AKN87_06885	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AKN87_06900	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
AKN87_06905	COG1012	belongs to the aldehyde dehydrogenase family
AKN87_06910	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
AKN87_06915	COG0704	Plays a role in the regulation of phosphate uptake
AKN87_06920	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
AKN87_06925	COG0581	inorganic phosphate transmembrane transporter activity
AKN87_06945	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
AKN87_06950	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
AKN87_06955	COG2963	transposase activity
AKN87_06975	COG0281	malic enzyme
AKN87_06980	COG0254	rRNA binding
AKN87_06985	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
AKN87_07015	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AKN87_07020	COG2274	protein secretion by the type I secretion system
AKN87_07040	COG0427	acetyl-CoA hydrolase
AKN87_07055	COG1752	Esterase of the alpha-beta hydrolase superfamily
AKN87_07060	COG1192	Involved in chromosome partitioning
AKN87_07065	COG0305	Participates in initiation and elongation during chromosome replication
AKN87_07130	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
AKN87_07135	COG1595	DNA-templated transcription, initiation
AKN87_07145	COG4771	TonB-dependent receptor
AKN87_07310	COG2814	Major facilitator Superfamily
AKN87_07320	COG3177	Filamentation induced by cAMP protein fic
AKN87_07325	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AKN87_07395	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
AKN87_07445	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
AKN87_07515	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AKN87_07525	COG0179	Fumarylacetoacetate (FAA) hydrolase
AKN87_07530	COG0277	FAD linked oxidase domain protein
AKN87_07535	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
AKN87_07545	COG2814	Major facilitator Superfamily
AKN87_07555	COG0753	catalase activity
AKN87_07565	COG0523	cobalamin synthesis protein
AKN87_07590	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
AKN87_07595	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AKN87_07605	COG0267	Belongs to the bacterial ribosomal protein bL33 family
AKN87_07610	COG0227	Belongs to the bacterial ribosomal protein bL28 family
AKN87_07615	COG2003	Belongs to the UPF0758 family
AKN87_07620	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
AKN87_07625	COG0756	dUTP diphosphatase activity
AKN87_07635	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
AKN87_07655	COG1160	GTP binding
AKN87_07680	COG0494	nUDIX hydrolase
AKN87_07690	COG1385	rRNA (uridine-N3-)-methyltransferase activity
AKN87_07700	COG1960	acyl-CoA dehydrogenase activity
AKN87_07725	COG1120	ATPase activity
AKN87_07730	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AKN87_07735	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AKN87_07740	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
AKN87_07755	COG2855	membrane
AKN87_07765	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
AKN87_07765	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
AKN87_07775	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
AKN87_07780	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AKN87_07785	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AKN87_07815	COG0730	response to heat
AKN87_07825	COG1414	Transcriptional regulator
AKN87_07835	COG4771	TonB-dependent receptor
AKN87_07845	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AKN87_07855	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
AKN87_07870	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
AKN87_07870	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
AKN87_07880	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
AKN87_07890	COG1979	alcohol dehydrogenase
AKN87_07895	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
AKN87_07900	COG0583	DNA-binding transcription factor activity
AKN87_07915	COG0814	amino acid
AKN87_07920	COG1368	sulfuric ester hydrolase activity
AKN87_07935	COG4149	molybdate abc transporter
AKN87_07940	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
AKN87_07955	COG1177	transmembrane transport
AKN87_07960	COG1176	ABC-type spermidine putrescine transport system, permease component I
AKN87_07965	COG3842	ATPase activity
AKN87_07980	COG3909	cytochrome
AKN87_07985	COG1652	LysM domain
AKN87_08010	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
AKN87_08020	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
AKN87_08025	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
AKN87_08035	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AKN87_08040	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
AKN87_08045	COG4942	peptidase
AKN87_08050	COG0793	Belongs to the peptidase S41A family
AKN87_08075	COG0131	Imidazoleglycerol-phosphate dehydratase
AKN87_08090	COG1194	a g-specific adenine glycosylase
AKN87_08095	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
AKN87_08110	COG1858	cytochrome C peroxidase
AKN87_08125	COG2353	YceI-like domain
AKN87_08130	COG3038	cytochrome b561
AKN87_08135	COG3241	Transfers electrons from cytochrome c551 to cytochrome oxidase
AKN87_08140	COG2193	ferroxidase activity
AKN87_08150	COG0126	phosphoglycerate kinase activity
AKN87_08155	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
AKN87_08165	COG1040	competence protein
AKN87_08170	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
AKN87_08175	COG0156	8-amino-7-oxononanoate synthase activity
AKN87_08180	COG1073	alpha beta
AKN87_08180	COG2226	methyltransferase
AKN87_08200	COG0303	'Molybdopterin
AKN87_08205	COG0521	Mo-molybdopterin cofactor biosynthetic process
AKN87_08235	COG1561	YicC-like family, N-terminal region
AKN87_08240	COG4628	conserved protein (DUF2132)
AKN87_08245	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
AKN87_08275	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
AKN87_08285	COG0826	peptidase U32
AKN87_08295	COG0318	PFAM AMP-dependent synthetase and ligase
AKN87_08315	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
AKN87_08320	COG0569	domain protein
AKN87_08325	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
AKN87_08330	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
AKN87_08335	COG0242	peptide deformylase activity
AKN87_08345	COG0758	DNA mediated transformation
AKN87_08350	COG0009	L-threonylcarbamoyladenylate synthase
AKN87_08360	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
AKN87_08365	COG2239	Acts as a magnesium transporter
AKN87_08370	COG1285	pathogenesis
AKN87_08385	COG1966	Carbon starvation protein
AKN87_08410	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
AKN87_08415	COG0730	response to heat
AKN87_08420	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
AKN87_08425	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
AKN87_08445	COG3154	lipid carrier protein
AKN87_08450	COG0826	peptidase U32
AKN87_08455	COG0826	peptidase U32
AKN87_08460	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
AKN87_08475	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
AKN87_08490	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
AKN87_08495	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
AKN87_08500	COG0252	asparaginase activity
AKN87_08530	COG1132	(ABC) transporter
AKN87_08535	COG0617	tRNA 3'-terminal CCA addition
AKN87_08535	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
AKN87_08535	COG3620	sequence-specific DNA binding
AKN87_08545	COG0789	Transcriptional regulator
AKN87_08580	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
AKN87_08585	COG0129	dihydroxy-acid dehydratase activity
AKN87_08600	COG3135	benzoate transporter
AKN87_08605	COG1178	ABC-type Fe3 transport system permease component
AKN87_08610	COG0404	The glycine cleavage system catalyzes the degradation of glycine
AKN87_08620	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
AKN87_08620	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
AKN87_08630	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
AKN87_08645	COG0742	ribosomal rna small subunit methyltransferase
AKN87_08650	COG0612	Peptidase, M16
AKN87_08655	COG0612	Peptidase, M16
AKN87_08665	COG0552	protein localization to endoplasmic reticulum
AKN87_08670	COG2884	Cell division ATP-binding protein ftsE
AKN87_08675	COG2177	Part of the ABC transporter FtsEX involved in
AKN87_08685	COG2431	L-lysine efflux transmembrane transporter activity
AKN87_08690	COG0833	amino acid
AKN87_08700	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
AKN87_08705	COG0513	Belongs to the DEAD box helicase family
AKN87_08710	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
AKN87_08715	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
AKN87_08770	COG0700	Nucleoside recognition
AKN87_08775	COG3023	N-Acetylmuramoyl-L-alanine amidase
AKN87_08785	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
AKN87_08790	COG0355	proton-transporting ATP synthase activity, rotational mechanism
AKN87_08795	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
AKN87_08800	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
AKN87_08805	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
AKN87_08810	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
AKN87_08815	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
AKN87_08825	COG0356	it plays a direct role in the translocation of protons across the membrane
AKN87_08835	COG1475	DNA binding
AKN87_08840	COG1192	Involved in chromosome partitioning
AKN87_08855	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
AKN87_08865	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
AKN87_08870	COG0594	ribonuclease P activity
AKN87_08875	COG0230	Belongs to the bacterial ribosomal protein bL34 family
AKN87_08910	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
AKN87_08925	COG1758	RNA polymerase activity
AKN87_08930	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
AKN87_08950	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
AKN87_08960	COG2363	Small membrane protein
AKN87_08970	COG2022	thiamine diphosphate biosynthetic process
AKN87_08975	COG0220	tRNA (guanine-N7-)-methyltransferase activity
AKN87_08995	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
AKN87_09000	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
AKN87_09015	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
AKN87_09030	COG0248	Ppx GppA phosphatase
AKN87_09040	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
AKN87_09045	COG0592	DNA-directed DNA polymerase activity
AKN87_09050	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
AKN87_09060	COG0642	Histidine kinase
AKN87_09075	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AKN87_09085	COG0159	tryptophan synthase activity
AKN87_09090	COG0133	tryptophan synthase activity
AKN87_09100	COG1960	acyl-CoA dehydrogenase activity
AKN87_09110	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
AKN87_09115	COG0583	DNA-binding transcription factor activity
AKN87_09120	COG3384	dioxygenase
AKN87_09130	COG3038	cytochrome b561
AKN87_09135	COG1289	transmembrane transporter activity
AKN87_09140	COG1944	ATP diphosphatase activity
AKN87_09145	COG2207	Transcriptional regulator
AKN87_09155	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
AKN87_09165	COG0303	'Molybdopterin
AKN87_09170	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
AKN87_09180	COG0642	Histidine kinase
AKN87_09190	COG1368	sulfuric ester hydrolase activity
AKN87_09220	COG0084	hydrolase, TatD family'
AKN87_09230	COG1451	nucleotide metabolic process
AKN87_09235	COG0071	Belongs to the small heat shock protein (HSP20) family
AKN87_09255	COG0175	sulfate reduction
AKN87_09260	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
AKN87_09260	COG1648	precorrin-2 dehydrogenase activity
AKN87_09270	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
AKN87_09275	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
AKN87_09280	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
AKN87_09285	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
AKN87_09295	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
AKN87_09305	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
AKN87_09320	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
AKN87_09330	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
AKN87_09335	COG0215	cysteine-tRNA ligase activity
AKN87_09345	COG1469	GTP cyclohydrolase I activity
AKN87_09350	COG0523	cobalamin synthesis protein
AKN87_09375	COG0306	phosphate transporter
AKN87_09380	COG1392	Phosphate transport regulator
AKN87_09390	COG0330	HflC and HflK could
AKN87_09425	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
AKN87_09435	COG0540	Belongs to the ATCase OTCase family
AKN87_09445	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
AKN87_09450	COG3204	pilus organization
AKN87_09460	COG0494	nUDIX hydrolase
AKN87_09465	COG1011	Hydrolase
AKN87_09495	COG1872	DUF167
AKN87_09500	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
AKN87_09505	COG2813	Specifically methylates the guanine in position
AKN87_09505	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
AKN87_09520	COG0635	Involved in the biosynthesis of porphyrin-containing compound
AKN87_09535	COG0583	DNA-binding transcription factor activity
AKN87_09540	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
AKN87_09555	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
AKN87_09575	COG0751	glycine-tRNA ligase activity
AKN87_09580	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
AKN87_09600	COG0347	Belongs to the P(II) protein family
AKN87_09615	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
AKN87_09620	COG3161	chorismate lyase activity
AKN87_09635	COG3258	Cytochrome c
AKN87_09640	COG2863	cytochrome
AKN87_09645	COG0606	chelatase, subunit chli
AKN87_09655	COG1028	Short-chain dehydrogenase reductase Sdr
AKN87_09660	COG1028	Short-chain dehydrogenase reductase Sdr
AKN87_09665	COG0019	diaminopimelate decarboxylase activity
AKN87_09690	COG4771	TonB-dependent receptor
AKN87_09700	COG4191	Histidine kinase
AKN87_09705	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
AKN87_09710	COG1519	Transferase
AKN87_09720	COG0501	Belongs to the peptidase M48B family
AKN87_09730	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AKN87_09735	COG3047	cAMP biosynthetic process
AKN87_09740	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
AKN87_09745	COG1490	D-aminoacyl-tRNA deacylase activity
AKN87_09750	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
AKN87_09755	COG0488	(ABC) transporter
AKN87_09765	COG2918	glutathione biosynthetic process
AKN87_09770	COG2183	response to ionizing radiation
AKN87_09785	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
AKN87_09790	COG0735	belongs to the Fur family
AKN87_09795	COG1121	(ABC) transporter
AKN87_09800	COG1108	ABC-type Mn2 Zn2 transport systems permease components
AKN87_09815	COG2011	ABC-type metal ion transport system permease component
AKN87_09825	COG1765	OsmC-like protein
AKN87_09830	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
AKN87_09835	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
AKN87_09840	COG0537	adenosine 5'-monophosphoramidase activity
AKN87_09845	COG1981	membrane
AKN87_09850	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
AKN87_09855	COG0316	Belongs to the HesB IscA family
AKN87_09860	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
AKN87_09865	COG0739	heme binding
AKN87_09870	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
AKN87_09900	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
AKN87_09900	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
AKN87_09905	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
AKN87_09930	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
AKN87_09950	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
AKN87_09955	COG0081	regulation of translation
AKN87_09960	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
AKN87_09965	COG0222	ribosome binding
AKN87_09970	COG0085	RNA polymerase activity
AKN87_09980	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
AKN87_09985	COG0049	tRNA binding
AKN87_09990	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
AKN87_09995	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
AKN87_10000	COG0051	transcription antitermination factor activity, RNA binding
AKN87_10005	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
AKN87_10010	COG0088	Forms part of the polypeptide exit tunnel
AKN87_10020	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
AKN87_10025	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
AKN87_10030	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
AKN87_10035	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
AKN87_10045	COG0255	Belongs to the universal ribosomal protein uL29 family
AKN87_10050	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
AKN87_10055	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
AKN87_10060	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
AKN87_10070	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
AKN87_10075	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
AKN87_10080	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
AKN87_10085	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
AKN87_10090	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
AKN87_10095	COG1841	ribosomal large subunit assembly
AKN87_10100	COG0200	Binds to the 23S rRNA
AKN87_10115	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
AKN87_10120	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
AKN87_10125	COG0202	RNA polymerase activity
AKN87_10130	COG0203	ribosomal protein L17
AKN87_10140	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
AKN87_10160	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
AKN87_10170	COG2081	HI0933 family
AKN87_10180	COG3263	regulation of cellular component size
AKN87_10185	COG3264	Mechanosensitive ion channel
AKN87_10185	COG1196	nuclear chromosome segregation
AKN87_10190	COG0676	glucose-6-phosphate 1-epimerase activity
AKN87_10215	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
AKN87_10220	COG2176	DNA-directed DNA polymerase activity
AKN87_10230	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
AKN87_10255	COG0697	spore germination
AKN87_10260	COG1917	Cupin 2, conserved barrel domain protein
AKN87_10260	COG2207	Transcriptional regulator
AKN87_10265	COG0113	porphobilinogen synthase activity
AKN87_10270	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
AKN87_10285	COG1960	acyl-CoA dehydrogenase activity
AKN87_10295	COG0318	PFAM AMP-dependent synthetase and ligase
AKN87_10300	COG4191	Histidine kinase
AKN87_10305	COG4566	intracellular signal transduction
AKN87_10310	COG0617	tRNA 3'-terminal CCA addition
AKN87_10335	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
AKN87_10350	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
AKN87_10355	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
AKN87_10360	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
AKN87_10375	COG1346	cytolysis
AKN87_10380	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
AKN87_10380	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
AKN87_10385	COG4989	oxidoreductase activity
AKN87_10395	COG1301	dicarboxylic acid transport
AKN87_10410	COG4659	FMN binding
AKN87_10415	COG4658	electron transport chain
AKN87_10425	COG2878	Part of a membrane complex involved in electron transport
AKN87_10430	COG4657	Part of a membrane complex involved in electron transport
AKN87_10440	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AKN87_10460	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
AKN87_10465	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
AKN87_10475	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
AKN87_10480	COG0501	Belongs to the peptidase M48B family
AKN87_10490	COG1643	Atp-dependent helicase
AKN87_10515	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
AKN87_10520	COG1802	Transcriptional regulator
AKN87_10530	COG0372	Belongs to the citrate synthase family
AKN87_10535	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
AKN87_10545	COG2264	protein methyltransferase activity
AKN87_10555	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AKN87_10565	COG0318	PFAM AMP-dependent synthetase and ligase
AKN87_10570	COG0183	Belongs to the thiolase family
AKN87_10600	COG2873	o-acetylhomoserine
AKN87_10610	COG1690	Belongs to the RtcB family
AKN87_10615	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AKN87_10630	COG0288	reversible hydration of carbon dioxide
AKN87_10645	COG0022	dehydrogenase e1 component
AKN87_10650	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
AKN87_10670	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
AKN87_10680	COG1028	Short-chain dehydrogenase reductase Sdr
AKN87_10685	COG0671	phosphoesterase, PA-phosphatase related
AKN87_10690	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
AKN87_10695	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
AKN87_10700	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
AKN87_10710	COG1607	acyl-coa hydrolase
AKN87_10720	COG0861	Integral membrane protein TerC family
AKN87_10730	COG0488	(ABC) transporter
AKN87_10755	COG0181	hydroxymethylbilane synthase activity
AKN87_10780	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
AKN87_10785	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
AKN87_10790	COG3956	TIGRFAM MazG family protein
AKN87_10795	COG3122	Protein conserved in bacteria
AKN87_10805	COG3258	Cytochrome c
AKN87_10810	COG0268	Binds directly to 16S ribosomal RNA
AKN87_10815	COG0728	peptidoglycan biosynthetic process
AKN87_10820	COG0196	riboflavin kinase activity
AKN87_10825	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
AKN87_10835	COG1047	Peptidyl-prolyl cis-trans
AKN87_10840	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
AKN87_10855	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
AKN87_10870	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
AKN87_10895	COG4574	serine-type endopeptidase inhibitor activity
AKN87_10905	COG0322	excinuclease ABC activity
AKN87_10920	COG3100	YcgL domain-containing protein
AKN87_10930	COG0675	Transposase, IS605 OrfB family
AKN87_10950	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
AKN87_10955	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
AKN87_10965	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AKN87_10995	COG0714	Associated with various cellular activities
AKN87_11000	COG0564	pseudouridine synthase activity
AKN87_11005	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
AKN87_11010	COG2894	cell division
AKN87_11015	COG0850	regulation of cytokinetic process
AKN87_11020	COG1560	Kdo2-lipid A biosynthetic process
AKN87_11030	COG2853	Lipoprotein
AKN87_11045	COG0489	protein tyrosine kinase activity
AKN87_11050	COG1278	Cold shock
AKN87_11055	COG0717	Belongs to the dCTP deaminase family
AKN87_11105	COG0659	secondary active sulfate transmembrane transporter activity
AKN87_11115	COG0431	NADPH-dependent FMN reductase
AKN87_11120	COG0798	PFAM Bile acid sodium symporter
AKN87_11135	COG1595	DNA-templated transcription, initiation
AKN87_11165	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
AKN87_11170	COG1733	regulation of RNA biosynthetic process
AKN87_11210	COG0582	viral genome integration into host DNA
AKN87_11255	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
AKN87_11285	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AKN87_11295	COG0859	PFAM glycosyl transferase family 9
AKN87_11300	COG0859	PFAM glycosyl transferase family 9
AKN87_11305	COG0438	transferase activity, transferring glycosyl groups
AKN87_11330	COG2192	nodulation
AKN87_11335	COG0438	transferase activity, transferring glycosyl groups
AKN87_11365	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
AKN87_11380	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
AKN87_11405	COG0438	transferase activity, transferring glycosyl groups
AKN87_11410	COG0438	transferase activity, transferring glycosyl groups
AKN87_11430	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
AKN87_11435	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
AKN87_11465	COG1252	NADH dehydrogenase
AKN87_11480	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
AKN87_11485	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
AKN87_11495	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
AKN87_11500	COG1077	Cell shape determining protein MreB Mrl
AKN87_11505	COG1792	Involved in formation and maintenance of cell shape
AKN87_11515	COG0424	maF-like protein
AKN87_11520	COG1530	ribonuclease E activity
AKN87_11530	COG0497	DNA recombination
AKN87_11535	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
AKN87_11540	COG0443	Heat shock 70 kDa protein
AKN87_11545	COG0484	heat shock protein binding
AKN87_11550	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
AKN87_11570	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
AKN87_11595	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
AKN87_11600	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AKN87_11605	COG0149	triose-phosphate isomerase activity
AKN87_11620	COG0779	Required for maturation of 30S ribosomal subunits
AKN87_11625	COG0195	Participates in both transcription termination and antitermination
AKN87_11630	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
AKN87_11635	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
AKN87_11640	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
AKN87_11645	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
AKN87_11650	COG1185	polyribonucleotide nucleotidyltransferase activity
AKN87_11660	COG0501	Belongs to the peptidase M48B family
AKN87_11665	COG3091	SprT-like family
AKN87_11680	COG0436	Aminotransferase
AKN87_11705	COG1104	cysteine desulfurase activity
AKN87_11715	COG0316	Belongs to the HesB IscA family
AKN87_11720	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
AKN87_11760	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
AKN87_11765	COG0124	histidyl-tRNA synthetase
AKN87_11780	COG1160	GTP binding
AKN87_11815	COG0446	pyridine nucleotide-disulphide oxidoreductase
AKN87_11815	COG1902	pentaerythritol trinitrate reductase activity
AKN87_11820	COG1530	ribonuclease E activity
AKN87_11840	COG0424	maF-like protein
AKN87_11845	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
AKN87_11855	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
AKN87_11860	COG0336	Belongs to the RNA methyltransferase TrmD family
AKN87_11870	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
AKN87_11880	COG2823	Periplasmic or secreted lipoprotein
AKN87_11890	COG0792	nuclease activity
AKN87_11895	COG3107	peptidoglycan biosynthetic process
AKN87_11905	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
AKN87_11920	COG3223	Belongs to the PsiE family
AKN87_11930	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
AKN87_11935	COG0312	modulator of DNA gyrase
AKN87_11940	COG3028	Belongs to the UPF0307 family
AKN87_11945	COG0312	modulator of DNA gyrase
AKN87_11950	COG0028	Belongs to the TPP enzyme family
AKN87_11965	COG1183	phosphatidylcholine synthase activity
AKN87_11995	COG0500	methyltransferase
AKN87_12015	COG0135	phosphoribosylanthranilate isomerase activity
AKN87_12020	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
AKN87_12025	COG0285	dihydrofolate synthase activity