locus-tag	class	description
AKN94_00010	COG1286	toxin biosynthetic process
AKN94_00025	COG2925	Exonuclease
AKN94_00040	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AKN94_00045	COG0544	peptidyl-prolyl cis-trans isomerase activity
AKN94_00055	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
AKN94_00060	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
AKN94_00070	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
AKN94_00075	COG3089	Belongs to the UPF0270 family
AKN94_00080	COG0431	NADPH-dependent FMN reductase
AKN94_00085	COG2056	Na+-H+ antiporter family
AKN94_00090	COG2837	iron assimilation
AKN94_00095	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
AKN94_00105	COG2914	Belongs to the UPF0125 (RnfH) family
AKN94_00110	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
AKN94_00120	COG2326	polyphosphate kinase activity
AKN94_00125	COG3081	Nucleoid-associated protein
AKN94_00140	COG3171	Protein conserved in bacteria
AKN94_00150	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AKN94_00170	COG2610	gluconate transmembrane transporter activity
AKN94_00180	COG2084	Dehydrogenase
AKN94_00185	COG3622	Belongs to the hyi family
AKN94_00215	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
AKN94_00220	COG0352	thiamine-phosphate diphosphorylase activity
AKN94_00225	COG0351	phosphomethylpyrimidine kinase
AKN94_00225	COG0352	thiamine-phosphate diphosphorylase activity
AKN94_00240	COG0495	leucyl-tRNA aminoacylation
AKN94_00250	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AKN94_00250	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
AKN94_00260	COG1196	nuclear chromosome segregation
AKN94_00265	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
AKN94_00270	COG1546	Belongs to the CinA family
AKN94_00280	COG2137	regulation of response to DNA damage stimulus
AKN94_00295	COG0513	Belongs to the DEAD box helicase family
AKN94_00300	COG1946	Acyl-CoA thioesterase
AKN94_00340	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
AKN94_00345	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
AKN94_00350	COG0772	Belongs to the SEDS family
AKN94_00365	COG1181	Belongs to the D-alanine--D-alanine ligase family
AKN94_00380	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
AKN94_00385	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
AKN94_00395	COG0653	protein targeting
AKN94_00405	COG0494	nUDIX hydrolase
AKN94_00410	COG2096	Adenosyltransferase
AKN94_00420	COG1666	GTP binding
AKN94_00425	COG0322	excinuclease ABC activity
AKN94_00435	COG0557	exoribonuclease II activity
AKN94_00440	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AKN94_00445	COG0360	Binds together with S18 to 16S ribosomal RNA
AKN94_00460	COG0359	binds to the 23S rRNA
AKN94_00465	COG0305	Participates in initiation and elongation during chromosome replication
AKN94_00485	COG0138	bifunctional purine biosynthesis protein purh
AKN94_00515	COG2135	peptidase activity
AKN94_00525	COG1660	Displays ATPase and GTPase activities
AKN94_00540	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
AKN94_00565	COG3201	nicotinamide mononucleotide transporter
AKN94_00575	COG1846	Transcriptional regulator
AKN94_00585	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
AKN94_00600	COG1805	sodium ion transport
AKN94_00625	COG1477	protein flavinylation
AKN94_00635	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AKN94_00645	COG4591	ABC-type transport system involved in lipoprotein release permease component
AKN94_00660	COG0436	Aminotransferase
AKN94_00665	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AKN94_00675	COG4536	flavin adenine dinucleotide binding
AKN94_00685	COG1399	metal-binding, possibly nucleic acid-binding protein
AKN94_00690	COG0333	Belongs to the bacterial ribosomal protein bL32 family
AKN94_00695	COG0416	fatty acid biosynthetic process
AKN94_00710	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
AKN94_00715	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
AKN94_00720	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
AKN94_00725	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
AKN94_00730	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
AKN94_00745	COG0084	hydrolase, TatD family'
AKN94_00750	COG1643	Atp-dependent helicase
AKN94_00755	COG0826	peptidase U32
AKN94_00765	COG1214	PFAM Peptidase M22, glycoprotease
AKN94_00770	COG0742	ribosomal rna small subunit methyltransferase
AKN94_00790	COG0564	pseudouridine synthase activity
AKN94_00805	COG3720	iron ion transport
AKN94_00815	COG0848	biopolymer transport protein
AKN94_00820	COG4558	Periplasmic binding protein
AKN94_00825	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AKN94_00830	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
AKN94_00850	COG0165	Argininosuccinate lyase
AKN94_00860	COG0530	calcium, potassium:sodium antiporter activity
AKN94_00865	COG0471	metal ion transport
AKN94_00870	COG0513	Belongs to the DEAD box helicase family
AKN94_00890	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
AKN94_00905	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
AKN94_00955	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AKN94_00975	COG0489	protein tyrosine kinase activity
AKN94_00975	COG3206	protein involved in exopolysaccharide biosynthesis
AKN94_01050	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
AKN94_01100	COG1968	undecaprenyl-diphosphatase activity
AKN94_01130	COG0542	response to heat
AKN94_01135	COG0586	Pfam SNARE associated Golgi protein
AKN94_01140	COG2094	Belongs to the DNA glycosylase MPG family
AKN94_01145	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
AKN94_01150	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
AKN94_01165	COG0768	penicillin binding
AKN94_01170	COG0772	Belongs to the SEDS family
AKN94_01175	COG2951	lytic endotransglycosylase activity
AKN94_01185	COG1686	Belongs to the peptidase S11 family
AKN94_01195	COG0321	lipoyl(octanoyl) transferase activity
AKN94_01200	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
AKN94_01210	COG2264	protein methyltransferase activity
AKN94_01235	COG0730	response to heat
AKN94_01240	COG0514	ATP-dependent DNA helicase (RecQ)
AKN94_01245	COG2076	Multidrug Resistance protein
AKN94_01255	COG5592	hemerythrin HHE cation binding domain
AKN94_01260	COG0602	queuosine metabolic process
AKN94_01265	COG0720	synthase
AKN94_01285	COG2823	Periplasmic or secreted lipoprotein
AKN94_01290	COG0363	glucosamine-6-phosphate deaminase activity
AKN94_01305	COG2967	ApaG domain
AKN94_01310	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
AKN94_01315	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AKN94_01325	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
AKN94_01335	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
AKN94_01345	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
AKN94_01350	COG0795	lipopolysaccharide-transporting ATPase activity
AKN94_01355	COG0795	lipopolysaccharide-transporting ATPase activity
AKN94_01360	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
AKN94_01365	COG2027	D-alanyl-D-alanine carboxypeptidase
AKN94_01375	COG2847	Copper chaperone PCu(A)C
AKN94_01380	COG1278	Cold shock
AKN94_01385	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
AKN94_01390	COG0542	response to heat
AKN94_01405	COG2030	dehydratase
AKN94_01410	COG0318	PFAM AMP-dependent synthetase and ligase
AKN94_01415	COG0589	response to stress
AKN94_01420	COG1252	NADH dehydrogenase
AKN94_01430	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
AKN94_01440	COG0148	phosphopyruvate hydratase activity
AKN94_01445	COG2877	3-deoxy-8-phosphooctulonate synthase activity
AKN94_01450	COG0504	CTP synthase activity
AKN94_01475	COG1199	ATP-dependent helicase activity
AKN94_01485	COG0167	dihydroorotate dehydrogenase activity
AKN94_01490	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AKN94_01500	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AKN94_01510	COG3243	poly(R)-hydroxyalkanoic acid synthase
AKN94_01520	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
AKN94_01535	COG0800	Aldolase
AKN94_01550	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
AKN94_01555	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
AKN94_01560	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
AKN94_01610	COG0582	viral genome integration into host DNA
AKN94_01660	COG2076	Multidrug Resistance protein
AKN94_01675	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
AKN94_01790	COG0189	ligase activity
AKN94_01805	COG2223	nitrite transmembrane transporter activity
AKN94_01825	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
AKN94_01835	COG2321	neutral zinc metallopeptidase
AKN94_01840	COG4988	ABC transporter
AKN94_01845	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
AKN94_01855	COG0328	RNA-DNA hybrid ribonuclease activity
AKN94_01860	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
AKN94_01925	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
AKN94_01935	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
AKN94_01940	COG1115	amino acid carrier protein
AKN94_01960	COG0425	Belongs to the sulfur carrier protein TusA family
AKN94_01965	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
AKN94_01970	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
AKN94_01990	COG0308	aminopeptidase N
AKN94_02005	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
AKN94_02020	COG1335	isochorismatase
AKN94_02025	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
AKN94_02030	COG4181	ATPase activity
AKN94_02045	COG0402	S-adenosylhomocysteine deaminase activity
AKN94_02085	COG0418	dihydroorotase activity
AKN94_02090	COG0137	argininosuccinate synthase activity
AKN94_02095	COG0346	lactoylglutathione lyase activity
AKN94_02110	COG1028	Short-chain dehydrogenase reductase Sdr
AKN94_02120	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
AKN94_02125	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
AKN94_02130	COG2252	PERMEase
AKN94_02145	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
AKN94_02150	COG0066	3-isopropylmalate dehydratase activity
AKN94_02175	COG0668	transmembrane transport
AKN94_02180	COG4133	protoheme IX ABC transporter activity
AKN94_02205	COG1138	Cytochrome C-type biogenesis protein
AKN94_02225	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
AKN94_02230	COG1360	Flagellar Motor Protein
AKN94_02245	COG3133	Outer membrane lipoprotein
AKN94_02290	COG1025	Belongs to the peptidase M16 family
AKN94_02320	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
AKN94_02350	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
AKN94_02355	COG1074	ATP-dependent DNA helicase activity
AKN94_02360	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
AKN94_02365	COG0393	Putative heavy-metal-binding
AKN94_02375	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
AKN94_02400	COG1024	Enoyl-CoA hydratase
AKN94_02415	COG2204	response regulator
AKN94_02420	COG4191	Histidine kinase
AKN94_02420	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AKN94_02450	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AKN94_02455	COG0481	GTPase activity
AKN94_02465	COG0571	ribonuclease III activity
AKN94_02470	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
AKN94_02475	COG1381	Involved in DNA repair and RecF pathway recombination
AKN94_02480	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
AKN94_02500	COG1131	(ABC) transporter
AKN94_02505	COG0842	Transport permease protein
AKN94_02510	COG0791	NLP P60 protein
AKN94_02515	COG0791	NLP P60 protein
AKN94_02520	COG0133	tryptophan synthase activity
AKN94_02530	COG0642	Histidine kinase
AKN94_02540	COG0745	RESPONSE REGULATOR receiver
AKN94_02545	COG2350	Protein conserved in bacteria
AKN94_02550	COG2917	probably involved in intracellular septation
AKN94_02555	COG0613	PHP domain protein
AKN94_02560	COG0009	L-threonylcarbamoyladenylate synthase
AKN94_02565	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
AKN94_02570	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
AKN94_02580	COG0535	radical SAM domain protein
AKN94_02590	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
AKN94_02645	COG0784	Response regulator, receiver
AKN94_02645	COG2205	protein histidine kinase activity
AKN94_02665	COG1397	ADP-ribosylglycohydrolase
AKN94_02670	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
AKN94_02680	COG0419	ATPase involved in DNA repair
AKN94_02685	COG0420	3'-5' exonuclease activity
AKN94_02695	COG0628	permease
AKN94_02705	COG0625	glutathione transferase activity
AKN94_02725	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
AKN94_02735	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
AKN94_02745	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AKN94_02750	COG2814	Major facilitator Superfamily
AKN94_02770	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
AKN94_02775	COG0585	pseudouridine synthase activity
AKN94_02780	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
AKN94_02790	COG2911	Protein conserved in bacteria
AKN94_02795	COG0729	surface antigen
AKN94_02800	COG0708	Exodeoxyribonuclease III
AKN94_02805	COG3781	membrane
AKN94_02810	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
AKN94_02815	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
AKN94_02820	COG1858	cytochrome C peroxidase
AKN94_02830	COG3409	Peptidoglycan-binding domain 1 protein
AKN94_02830	COG0860	N-Acetylmuramoyl-L-alanine amidase
AKN94_02860	COG0037	tRNA processing
AKN94_02880	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
AKN94_02890	COG0560	Phosphoserine phosphatase
AKN94_02910	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AKN94_02925	COG4953	penicillin-binding protein 1C
AKN94_02935	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
AKN94_02940	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
AKN94_02945	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
AKN94_02950	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
AKN94_02955	COG5007	Belongs to the BolA IbaG family
AKN94_02975	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
AKN94_02980	COG1127	ABC transporter
AKN94_02990	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
AKN94_03000	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
AKN94_03005	COG1137	ATPase activity
AKN94_03020	COG1132	(ABC) transporter
AKN94_03045	COG0730	response to heat
AKN94_03060	COG1024	Enoyl-CoA hydratase
AKN94_03065	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
AKN94_03075	COG2010	Cytochrome c
AKN94_03080	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AKN94_03080	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
AKN94_03085	COG0023	Translation Initiation Factor
AKN94_03090	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AKN94_03100	COG2119	membrane
AKN94_03105	COG5394	Polyhydroxyalkanoate synthesis repressor PhaR
AKN94_03110	COG0675	Transposase, IS605 OrfB family
AKN94_03135	COG1335	isochorismatase
AKN94_03195	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AKN94_03200	COG2373	Large extracellular alpha-helical protein
AKN94_03215	COG0433	COG0433 Predicted ATPase
AKN94_03220	COG0788	formyltetrahydrofolate deformylase activity
AKN94_03225	COG2853	Lipoprotein
AKN94_03230	COG0215	cysteine-tRNA ligase activity
AKN94_03235	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AKN94_03240	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
AKN94_03245	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AKN94_03250	COG2031	fatty acid transporter
AKN94_03255	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
AKN94_03260	COG3115	cell septum assembly
AKN94_03265	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
AKN94_03270	COG2824	Alkylphosphonate utilization operon protein PhnA
AKN94_03280	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
AKN94_03285	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
AKN94_03290	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
AKN94_03295	COG0077	Prephenate dehydratase
AKN94_03295	COG1605	Chorismate mutase
AKN94_03310	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
AKN94_03315	COG1132	(ABC) transporter
AKN94_03335	COG0271	Belongs to the BolA IbaG family
AKN94_03365	COG0848	biopolymer transport protein
AKN94_03370	COG0811	peptide transport
AKN94_03375	COG0811	peptide transport
AKN94_03385	COG0121	glutamine amidotransferase
AKN94_03395	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
AKN94_03425	COG0730	response to heat
AKN94_03430	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
AKN94_03445	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
AKN94_03450	COG4208	sulfate ABC transporter
AKN94_03460	COG0469	pyruvate kinase activity
AKN94_03465	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
AKN94_03470	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
AKN94_03475	COG3842	ATPase activity
AKN94_03495	COG2885	chlorophyll binding
AKN94_03505	COG0427	acetyl-CoA hydrolase
AKN94_03530	COG0513	Belongs to the DEAD box helicase family
AKN94_03545	COG2212	antiporter activity
AKN94_03555	COG0651	ATP synthesis coupled electron transport
AKN94_03565	COG0604	alcohol dehydrogenase
AKN94_03580	COG0556	nucleotide-excision repair
AKN94_03590	COG1136	(ABC) transporter
AKN94_03605	COG2996	Protein conserved in bacteria
AKN94_03615	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AKN94_03620	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AKN94_03625	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
AKN94_03630	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AKN94_03640	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
AKN94_03650	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
AKN94_03660	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
AKN94_03665	COG0233	cytoplasmic translational termination
AKN94_03670	COG0528	UMP kinase activity
AKN94_03675	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
AKN94_03680	COG0052	Belongs to the universal ribosomal protein uS2 family
AKN94_03685	COG0024	Methionine aminopeptidase
AKN94_03690	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
AKN94_03695	COG1393	Belongs to the ArsC family
AKN94_03700	COG2171	N-acyltransferase activity
AKN94_03705	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
AKN94_03710	COG2166	iron-sulfur cluster assembly
AKN94_03745	COG2814	Major facilitator Superfamily
AKN94_03755	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
AKN94_03760	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
AKN94_03770	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
AKN94_03775	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
AKN94_03785	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
AKN94_03790	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
AKN94_03805	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
AKN94_03820	COG0604	alcohol dehydrogenase
AKN94_03825	COG0616	signal peptide processing
AKN94_03850	COG0812	UDP-N-acetylmuramate dehydrogenase activity
AKN94_03855	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
AKN94_03860	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
AKN94_03865	COG2835	tetraacyldisaccharide 4'-kinase activity
AKN94_03870	COG1663	tetraacyldisaccharide 4'-kinase activity
AKN94_03875	COG2333	competence protein COMEC
AKN94_03875	COG0658	competence protein
AKN94_03885	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
AKN94_03925	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
AKN94_03935	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
AKN94_03945	COG0037	tRNA processing
AKN94_03950	COG2814	Major facilitator Superfamily
AKN94_03955	COG0284	orotidine-5'-phosphate decarboxylase activity
AKN94_03960	COG0114	fumarate hydratase activity
AKN94_03965	COG0730	response to heat
AKN94_03990	COG1862	Preprotein translocase
AKN94_04000	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
AKN94_04010	COG2259	Doxx family
AKN94_04015	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
AKN94_04020	COG2366	antibiotic biosynthetic process
AKN94_04025	COG2885	chlorophyll binding
AKN94_04040	COG0400	carboxylic ester hydrolase activity
AKN94_04045	COG0513	Belongs to the DEAD box helicase family
AKN94_04050	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
AKN94_04060	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AKN94_04070	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
AKN94_04075	COG0425	Belongs to the sulfur carrier protein TusA family
AKN94_04080	COG4783	chaperone-mediated protein folding
AKN94_04085	COG2855	membrane
AKN94_04090	COG2814	Major facilitator Superfamily
AKN94_04095	COG2356	endonuclease I
AKN94_04105	COG1272	protein, Hemolysin III
AKN94_04125	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
AKN94_04130	COG0492	ferredoxin-NADP+ reductase activity
AKN94_04135	COG0456	acetyltransferase
AKN94_04160	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
AKN94_04165	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AKN94_04170	COG1120	ATPase activity
AKN94_04180	COG1492	cobalamin metabolic process
AKN94_04185	COG0778	Nitroreductase
AKN94_04205	COG0583	DNA-binding transcription factor activity
AKN94_04245	COG0318	PFAM AMP-dependent synthetase and ligase
AKN94_04250	COG1960	acyl-CoA dehydrogenase activity
AKN94_04255	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
AKN94_04260	COG1024	Enoyl-CoA hydratase
AKN94_04260	COG1250	3-hydroxyacyl-CoA dehydrogenase
AKN94_04285	COG0789	Transcriptional regulator
AKN94_04290	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
AKN94_04315	COG0045	succinate-CoA ligase (ADP-forming) activity
AKN94_04335	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
AKN94_04350	COG2009	succinate dehydrogenase
AKN94_04370	COG2084	Dehydrogenase
AKN94_04380	COG3278	Belongs to the heme-copper respiratory oxidase family
AKN94_04395	COG2010	Cytochrome c
AKN94_04410	COG2217	Heavy metal translocating P-type atpase
AKN94_04435	COG2175	clavaminate synthase activity
AKN94_04440	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AKN94_04445	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
AKN94_04450	COG4521	taurine ABC transporter
AKN94_04455	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
AKN94_04460	COG0492	ferredoxin-NADP+ reductase activity
AKN94_04480	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AKN94_04500	COG0776	regulation of translation
AKN94_04505	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
AKN94_04505	COG0316	Belongs to the HesB IscA family
AKN94_04510	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
AKN94_04530	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
AKN94_04535	COG2840	Smr protein MutS2
AKN94_04550	COG1196	nuclear chromosome segregation
AKN94_04550	COG0741	lytic transglycosylase activity
AKN94_04550	COG0739	heme binding
AKN94_04565	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
AKN94_04570	COG0018	arginyl-trna synthetase
AKN94_04585	COG4206	TonB-dependent receptor
AKN94_04595	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
AKN94_04605	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
AKN94_04615	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
AKN94_04615	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
AKN94_04620	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
AKN94_04630	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
AKN94_04650	COG1309	transcriptional regulator
AKN94_04675	COG0183	Belongs to the thiolase family
AKN94_04680	COG1024	Enoyl-CoA hydratase
AKN94_04680	COG1250	3-hydroxyacyl-CoA dehydrogenase
AKN94_04685	COG0589	response to stress
AKN94_04690	COG0405	Gamma-glutamyltransferase
AKN94_04695	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
AKN94_04700	COG0488	(ABC) transporter
AKN94_04715	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
AKN94_04720	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
AKN94_04730	COG1388	LysM domain
AKN94_04730	COG0741	lytic transglycosylase activity
AKN94_04740	COG4166	transmembrane transport
AKN94_04745	COG4174	ABC transporter (Permease)
AKN94_04750	COG4239	(ABC) transporter, permease
AKN94_04755	COG4172	Belongs to the ABC transporter superfamily
AKN94_04775	COG5394	Polyhydroxyalkanoate synthesis repressor PhaR
AKN94_04780	COG0675	Transposase, IS605 OrfB family
AKN94_04800	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
AKN94_04805	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
AKN94_04810	COG0482	sulfurtransferase activity
AKN94_04815	COG2915	High frequency lysogenization protein hflD homolog
AKN94_04820	COG0697	spore germination
AKN94_04830	COG2850	peptidyl-arginine hydroxylation
AKN94_04835	COG2153	protein acetylation
AKN94_04855	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
AKN94_04865	COG2226	methyltransferase
AKN94_04880	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
AKN94_04895	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
AKN94_04900	COG2860	membrane
AKN94_04905	COG0644	oxidoreductase
AKN94_04945	COG1132	(ABC) transporter
AKN94_04950	COG3284	Transcriptional regulator
AKN94_04985	COG0435	Glutathione S-transferase
AKN94_04995	COG1522	sequence-specific DNA binding
AKN94_05000	COG0312	modulator of DNA gyrase
AKN94_05005	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
AKN94_05015	COG3223	Belongs to the PsiE family
AKN94_05030	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
AKN94_05040	COG3107	peptidoglycan biosynthetic process
AKN94_05045	COG0792	nuclease activity
AKN94_05055	COG2823	Periplasmic or secreted lipoprotein
AKN94_05065	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
AKN94_05075	COG0336	Belongs to the RNA methyltransferase TrmD family
AKN94_05080	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
AKN94_05090	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
AKN94_05095	COG0424	maF-like protein
AKN94_05120	COG1530	ribonuclease E activity
AKN94_05125	COG0446	pyridine nucleotide-disulphide oxidoreductase
AKN94_05125	COG1902	pentaerythritol trinitrate reductase activity
AKN94_05160	COG1160	GTP binding
AKN94_05175	COG0124	histidyl-tRNA synthetase
AKN94_05180	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
AKN94_05220	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
AKN94_05225	COG0316	Belongs to the HesB IscA family
AKN94_05235	COG1104	cysteine desulfurase activity
AKN94_05260	COG0436	Aminotransferase
AKN94_05275	COG3091	SprT-like family
AKN94_05280	COG0501	Belongs to the peptidase M48B family
AKN94_05290	COG1185	polyribonucleotide nucleotidyltransferase activity
AKN94_05295	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
AKN94_05300	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
AKN94_05305	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
AKN94_05310	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
AKN94_05315	COG0195	Participates in both transcription termination and antitermination
AKN94_05320	COG0779	Required for maturation of 30S ribosomal subunits
AKN94_05335	COG0149	triose-phosphate isomerase activity
AKN94_05340	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AKN94_05345	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
AKN94_05370	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
AKN94_05390	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
AKN94_05395	COG0484	heat shock protein binding
AKN94_05400	COG0443	Heat shock 70 kDa protein
AKN94_05405	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
AKN94_05410	COG0497	DNA recombination
AKN94_05420	COG1530	ribonuclease E activity
AKN94_05425	COG0424	maF-like protein
AKN94_05435	COG1792	Involved in formation and maintenance of cell shape
AKN94_05440	COG1077	Cell shape determining protein MreB Mrl
AKN94_05445	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
AKN94_05455	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
AKN94_05460	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
AKN94_05470	COG1252	NADH dehydrogenase
AKN94_05480	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
AKN94_05485	COG1215	transferase activity, transferring glycosyl groups
AKN94_05490	COG3475	LICD family
AKN94_05495	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
AKN94_05535	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
AKN94_05550	COG0438	transferase activity, transferring glycosyl groups
AKN94_05550	COG0297	glycogen (starch) synthase activity
AKN94_05560	COG0438	transferase activity, transferring glycosyl groups
AKN94_05565	COG2192	nodulation
AKN94_05590	COG0438	transferase activity, transferring glycosyl groups
AKN94_05595	COG0859	PFAM glycosyl transferase family 9
AKN94_05600	COG0859	PFAM glycosyl transferase family 9
AKN94_05615	COG0506	proline dehydrogenase activity
AKN94_05615	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
AKN94_05615	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
AKN94_05640	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
AKN94_05665	COG0717	Belongs to the dCTP deaminase family
AKN94_05670	COG1278	Cold shock
AKN94_05675	COG0489	protein tyrosine kinase activity
AKN94_05690	COG2853	Lipoprotein
AKN94_05700	COG1560	Kdo2-lipid A biosynthetic process
AKN94_05705	COG0850	regulation of cytokinetic process
AKN94_05710	COG2894	cell division
AKN94_05715	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
AKN94_05720	COG0564	pseudouridine synthase activity
AKN94_05725	COG0714	Associated with various cellular activities
AKN94_05755	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AKN94_05765	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
AKN94_05770	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
AKN94_05785	COG1555	photosystem II stabilization
AKN94_05790	COG3100	YcgL domain-containing protein
AKN94_05805	COG0322	excinuclease ABC activity
AKN94_05815	COG4574	serine-type endopeptidase inhibitor activity
AKN94_05840	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
AKN94_05855	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
AKN94_05870	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
AKN94_05875	COG1047	Peptidyl-prolyl cis-trans
AKN94_05885	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
AKN94_05890	COG0196	riboflavin kinase activity
AKN94_05895	COG0728	peptidoglycan biosynthetic process
AKN94_05900	COG0268	Binds directly to 16S ribosomal RNA
AKN94_05905	COG3258	Cytochrome c
AKN94_05915	COG3122	Protein conserved in bacteria
AKN94_05920	COG3956	TIGRFAM MazG family protein
AKN94_05925	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
AKN94_05930	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
AKN94_05955	COG0181	hydroxymethylbilane synthase activity
AKN94_05980	COG0488	(ABC) transporter
AKN94_05990	COG0861	Integral membrane protein TerC family
AKN94_06000	COG1607	acyl-coa hydrolase
AKN94_06010	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
AKN94_06015	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
AKN94_06020	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
AKN94_06025	COG0671	phosphoesterase, PA-phosphatase related
AKN94_06030	COG1028	Short-chain dehydrogenase reductase Sdr
AKN94_06040	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
AKN94_06060	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
AKN94_06065	COG0022	dehydrogenase e1 component
AKN94_06080	COG0288	reversible hydration of carbon dioxide
AKN94_06095	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AKN94_06100	COG1690	Belongs to the RtcB family
AKN94_06110	COG2873	o-acetylhomoserine
AKN94_06140	COG0183	Belongs to the thiolase family
AKN94_06145	COG0318	PFAM AMP-dependent synthetase and ligase
AKN94_06155	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AKN94_06165	COG2264	protein methyltransferase activity
AKN94_06175	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
AKN94_06180	COG0372	Belongs to the citrate synthase family
AKN94_06190	COG1802	Transcriptional regulator
AKN94_06195	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
AKN94_06220	COG1643	Atp-dependent helicase
AKN94_06230	COG0501	Belongs to the peptidase M48B family
AKN94_06235	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
AKN94_06245	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
AKN94_06250	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
AKN94_06270	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AKN94_06280	COG4657	Part of a membrane complex involved in electron transport
AKN94_06285	COG2878	Part of a membrane complex involved in electron transport
AKN94_06295	COG4658	electron transport chain
AKN94_06300	COG4659	FMN binding
AKN94_06315	COG1301	dicarboxylic acid transport
AKN94_06325	COG4989	oxidoreductase activity
AKN94_06330	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
AKN94_06330	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
AKN94_06335	COG1346	cytolysis
AKN94_06350	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
AKN94_06355	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
AKN94_06360	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
AKN94_06375	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
AKN94_06400	COG0617	tRNA 3'-terminal CCA addition
AKN94_06405	COG4566	intracellular signal transduction
AKN94_06410	COG4191	Histidine kinase
AKN94_06415	COG0318	PFAM AMP-dependent synthetase and ligase
AKN94_06425	COG1960	acyl-CoA dehydrogenase activity
AKN94_06440	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
AKN94_06445	COG0113	porphobilinogen synthase activity
AKN94_06450	COG1917	Cupin 2, conserved barrel domain protein
AKN94_06450	COG2207	Transcriptional regulator
AKN94_06455	COG0697	spore germination
AKN94_06480	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
AKN94_06490	COG2176	DNA-directed DNA polymerase activity
AKN94_06495	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
AKN94_06520	COG0676	glucose-6-phosphate 1-epimerase activity
AKN94_06525	COG3264	Mechanosensitive ion channel
AKN94_06525	COG1196	nuclear chromosome segregation
AKN94_06530	COG3263	regulation of cellular component size
AKN94_06540	COG2081	HI0933 family
AKN94_06555	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
AKN94_06575	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
AKN94_06585	COG0203	ribosomal protein L17
AKN94_06590	COG0202	RNA polymerase activity
AKN94_06595	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
AKN94_06600	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
AKN94_06615	COG0200	Binds to the 23S rRNA
AKN94_06620	COG1841	ribosomal large subunit assembly
AKN94_06625	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
AKN94_06630	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
AKN94_06635	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
AKN94_06640	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
AKN94_06645	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
AKN94_06655	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
AKN94_06660	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
AKN94_06665	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
AKN94_06670	COG0255	Belongs to the universal ribosomal protein uL29 family
AKN94_06680	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
AKN94_06685	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
AKN94_06690	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
AKN94_06695	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
AKN94_06705	COG0088	Forms part of the polypeptide exit tunnel
AKN94_06710	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
AKN94_06715	COG0051	transcription antitermination factor activity, RNA binding
AKN94_06720	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
AKN94_06725	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
AKN94_06730	COG0049	tRNA binding
AKN94_06735	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
AKN94_06745	COG0085	RNA polymerase activity
AKN94_06750	COG0222	ribosome binding
AKN94_06755	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
AKN94_06760	COG0081	regulation of translation
AKN94_06765	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
AKN94_06785	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
AKN94_06810	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
AKN94_06815	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
AKN94_06815	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
AKN94_06845	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
AKN94_06850	COG0739	heme binding
AKN94_06855	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
AKN94_06860	COG0316	Belongs to the HesB IscA family
AKN94_06865	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
AKN94_06870	COG1981	membrane
AKN94_06875	COG0537	adenosine 5'-monophosphoramidase activity
AKN94_06880	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
AKN94_06885	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
AKN94_06890	COG1765	OsmC-like protein
AKN94_06900	COG2011	ABC-type metal ion transport system permease component
AKN94_06915	COG1108	ABC-type Mn2 Zn2 transport systems permease components
AKN94_06920	COG1121	(ABC) transporter
AKN94_06925	COG0735	belongs to the Fur family
AKN94_06940	COG2011	ABC-type metal ion transport system permease component
AKN94_06955	COG1108	ABC-type Mn2 Zn2 transport systems permease components
AKN94_06960	COG1121	(ABC) transporter
AKN94_06965	COG0735	belongs to the Fur family
AKN94_06975	COG2183	response to ionizing radiation
AKN94_06980	COG2918	glutathione biosynthetic process
AKN94_06990	COG0488	(ABC) transporter
AKN94_06995	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
AKN94_07000	COG1490	D-aminoacyl-tRNA deacylase activity
AKN94_07005	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
AKN94_07010	COG3047	cAMP biosynthetic process
AKN94_07015	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AKN94_07025	COG0501	Belongs to the peptidase M48B family
AKN94_07035	COG1519	Transferase
AKN94_07040	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
AKN94_07045	COG4191	Histidine kinase
AKN94_07055	COG4771	TonB-dependent receptor
AKN94_07075	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
AKN94_07080	COG0019	diaminopimelate decarboxylase activity
AKN94_07085	COG1028	Short-chain dehydrogenase reductase Sdr
AKN94_07090	COG1028	Short-chain dehydrogenase reductase Sdr
AKN94_07100	COG0606	chelatase, subunit chli
AKN94_07105	COG2863	cytochrome
AKN94_07110	COG3258	Cytochrome c
AKN94_07125	COG3161	chorismate lyase activity
AKN94_07145	COG0347	Belongs to the P(II) protein family
AKN94_07195	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
AKN94_07200	COG0751	glycine-tRNA ligase activity
AKN94_07220	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
AKN94_07235	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
AKN94_07240	COG0583	DNA-binding transcription factor activity
AKN94_07255	COG0635	Involved in the biosynthesis of porphyrin-containing compound
AKN94_07270	COG2813	Specifically methylates the guanine in position
AKN94_07270	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
AKN94_07275	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
AKN94_07280	COG1872	DUF167
AKN94_07310	COG1011	Hydrolase
AKN94_07315	COG0494	nUDIX hydrolase
AKN94_07325	COG3204	pilus organization
AKN94_07330	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
AKN94_07340	COG0540	Belongs to the ATCase OTCase family
AKN94_07350	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
AKN94_07385	COG0330	HflC and HflK could
AKN94_07395	COG1392	Phosphate transport regulator
AKN94_07400	COG0306	phosphate transporter
AKN94_07420	COG1648	precorrin-2 dehydrogenase activity
AKN94_07420	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
AKN94_07425	COG0175	sulfate reduction
AKN94_07445	COG0071	Belongs to the small heat shock protein (HSP20) family
AKN94_07450	COG1451	nucleotide metabolic process
AKN94_07460	COG0084	hydrolase, TatD family'
AKN94_07490	COG1368	sulfuric ester hydrolase activity
AKN94_07495	COG0745	RESPONSE REGULATOR receiver
AKN94_07500	COG0642	Histidine kinase
AKN94_07510	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
AKN94_07515	COG0303	'Molybdopterin
AKN94_07525	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
AKN94_07535	COG2207	Transcriptional regulator
AKN94_07540	COG1944	ATP diphosphatase activity
AKN94_07545	COG1289	transmembrane transporter activity
AKN94_07550	COG3038	cytochrome b561
AKN94_07560	COG3384	dioxygenase
AKN94_07565	COG0583	DNA-binding transcription factor activity
AKN94_07570	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
AKN94_07580	COG1960	acyl-CoA dehydrogenase activity
AKN94_07590	COG0133	tryptophan synthase activity
AKN94_07595	COG0159	tryptophan synthase activity
AKN94_07605	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AKN94_07620	COG0642	Histidine kinase
AKN94_07630	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
AKN94_07635	COG0592	DNA-directed DNA polymerase activity
AKN94_07640	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
AKN94_07650	COG0248	Ppx GppA phosphatase
AKN94_07665	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
AKN94_07675	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
AKN94_07680	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
AKN94_07700	COG0220	tRNA (guanine-N7-)-methyltransferase activity
AKN94_07705	COG2022	thiamine diphosphate biosynthetic process
AKN94_07715	COG2363	Small membrane protein
AKN94_07725	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
AKN94_07745	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
AKN94_07750	COG1758	RNA polymerase activity
AKN94_07765	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
AKN94_07800	COG0230	Belongs to the bacterial ribosomal protein bL34 family
AKN94_07805	COG0594	ribonuclease P activity
AKN94_07810	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
AKN94_07820	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
AKN94_07835	COG1192	Involved in chromosome partitioning
AKN94_07840	COG1475	DNA binding
AKN94_07860	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AKN94_07880	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
AKN94_07885	COG1509	lysine 2,3-aminomutase activity
AKN94_07890	COG0513	Belongs to the DEAD box helicase family
AKN94_07895	COG3530	Putative quorum-sensing-regulated virulence factor
AKN94_07920	COG0142	geranyltranstransferase activity
AKN94_07925	COG1722	exodeoxyribonuclease VII activity
AKN94_07935	COG0456	acetyltransferase
AKN94_07940	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
AKN94_07970	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
AKN94_07975	COG0546	phosphoglycolate phosphatase activity
AKN94_07990	COG2431	L-lysine efflux transmembrane transporter activity
AKN94_08000	COG2177	Part of the ABC transporter FtsEX involved in
AKN94_08005	COG2884	Cell division ATP-binding protein ftsE
AKN94_08010	COG0552	protein localization to endoplasmic reticulum
AKN94_08015	COG0612	Peptidase, M16
AKN94_08020	COG0612	Peptidase, M16
AKN94_08025	COG0742	ribosomal rna small subunit methyltransferase
AKN94_08040	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
AKN94_08050	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
AKN94_08050	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
AKN94_08060	COG0404	The glycine cleavage system catalyzes the degradation of glycine
AKN94_08065	COG1178	ABC-type Fe3 transport system permease component
AKN94_08070	COG3135	benzoate transporter
AKN94_08085	COG0129	dihydroxy-acid dehydratase activity
AKN94_08090	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
AKN94_08125	COG0270	DNA (cytosine-5-)-methyltransferase activity
AKN94_08175	COG0789	Transcriptional regulator
AKN94_08185	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
AKN94_08185	COG0617	tRNA 3'-terminal CCA addition
AKN94_08185	COG3620	sequence-specific DNA binding
AKN94_08190	COG1132	(ABC) transporter
AKN94_08195	COG2610	gluconate transmembrane transporter activity
AKN94_08200	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AKN94_08235	COG0252	asparaginase activity
AKN94_08245	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
AKN94_08250	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
AKN94_08265	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
AKN94_08280	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
AKN94_08285	COG0826	peptidase U32
AKN94_08290	COG0826	peptidase U32
AKN94_08295	COG3154	lipid carrier protein
AKN94_08315	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
AKN94_08320	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
AKN94_08325	COG0730	response to heat
AKN94_08330	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
AKN94_08355	COG1966	Carbon starvation protein
AKN94_08365	COG0003	Pfam Anion-transporting ATPase
AKN94_08370	COG1285	pathogenesis
AKN94_08375	COG2239	Acts as a magnesium transporter
AKN94_08380	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
AKN94_08390	COG0009	L-threonylcarbamoyladenylate synthase
AKN94_08395	COG0758	DNA mediated transformation
AKN94_08400	COG0242	peptide deformylase activity
AKN94_08405	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
AKN94_08410	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
AKN94_08415	COG0569	domain protein
AKN94_08420	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
AKN94_08440	COG0318	PFAM AMP-dependent synthetase and ligase
AKN94_08450	COG0826	peptidase U32
AKN94_08460	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
AKN94_08485	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
AKN94_08490	COG4628	conserved protein (DUF2132)
AKN94_08495	COG1561	YicC-like family, N-terminal region
AKN94_08565	COG0515	serine threonine protein kinase
AKN94_08565	COG2815	serine threonine protein kinase
AKN94_08615	COG0521	Mo-molybdopterin cofactor biosynthetic process
AKN94_08620	COG0303	'Molybdopterin
AKN94_08640	COG1073	alpha beta
AKN94_08640	COG2226	methyltransferase
AKN94_08645	COG0156	8-amino-7-oxononanoate synthase activity
AKN94_08650	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
AKN94_08665	COG1040	competence protein
AKN94_08675	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
AKN94_08680	COG0126	phosphoglycerate kinase activity
AKN94_08690	COG2193	ferroxidase activity
AKN94_08695	COG3241	Transfers electrons from cytochrome c551 to cytochrome oxidase
AKN94_08700	COG3038	cytochrome b561
AKN94_08705	COG2353	YceI-like domain
AKN94_08730	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
AKN94_08735	COG1194	a g-specific adenine glycosylase
AKN94_08750	COG0131	Imidazoleglycerol-phosphate dehydratase
AKN94_08775	COG0793	Belongs to the peptidase S41A family
AKN94_08780	COG4942	peptidase
AKN94_08785	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
AKN94_08790	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AKN94_08800	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
AKN94_08805	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
AKN94_08815	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
AKN94_08840	COG1652	LysM domain
AKN94_08845	COG3909	cytochrome
AKN94_08860	COG3842	ATPase activity
AKN94_08865	COG1176	ABC-type spermidine putrescine transport system, permease component I
AKN94_08870	COG1177	transmembrane transport
AKN94_08885	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
AKN94_08890	COG4149	molybdate abc transporter
AKN94_08905	COG1368	sulfuric ester hydrolase activity
AKN94_08910	COG0814	amino acid
AKN94_08925	COG0583	DNA-binding transcription factor activity
AKN94_08930	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
AKN94_08935	COG1979	alcohol dehydrogenase
AKN94_08945	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
AKN94_08955	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
AKN94_08955	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
AKN94_08970	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
AKN94_08980	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AKN94_08990	COG4771	TonB-dependent receptor
AKN94_09000	COG1414	Transcriptional regulator
AKN94_09010	COG0730	response to heat
AKN94_09040	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AKN94_09055	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AKN94_09060	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
AKN94_09070	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
AKN94_09070	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
AKN94_09080	COG2855	membrane
AKN94_09095	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
AKN94_09100	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AKN94_09105	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AKN94_09110	COG1120	ATPase activity
AKN94_09130	COG1960	acyl-CoA dehydrogenase activity
AKN94_09140	COG1385	rRNA (uridine-N3-)-methyltransferase activity
AKN94_09150	COG0494	nUDIX hydrolase
AKN94_09175	COG1160	GTP binding
AKN94_09195	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
AKN94_09205	COG0756	dUTP diphosphatase activity
AKN94_09210	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
AKN94_09215	COG2003	Belongs to the UPF0758 family
AKN94_09220	COG0227	Belongs to the bacterial ribosomal protein bL28 family
AKN94_09225	COG0267	Belongs to the bacterial ribosomal protein bL33 family
AKN94_09235	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AKN94_09240	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
AKN94_09265	COG0523	cobalamin synthesis protein
AKN94_09275	COG0753	catalase activity
AKN94_09285	COG2814	Major facilitator Superfamily
AKN94_09295	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
AKN94_09300	COG0277	FAD linked oxidase domain protein
AKN94_09305	COG0179	Fumarylacetoacetate (FAA) hydrolase
AKN94_09315	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AKN94_09340	COG1752	Esterase of the alpha-beta hydrolase superfamily
AKN94_09355	COG0427	acetyl-CoA hydrolase
AKN94_09375	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
AKN94_09380	COG0254	rRNA binding
AKN94_09385	COG0281	malic enzyme
AKN94_09420	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
AKN94_09425	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
AKN94_09445	COG0573	inorganic phosphate transmembrane transporter activity
AKN94_09450	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
AKN94_09455	COG0704	Plays a role in the regulation of phosphate uptake
AKN94_09460	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
AKN94_09465	COG1012	belongs to the aldehyde dehydrogenase family
AKN94_09470	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
AKN94_09485	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AKN94_09485	COG0301	tRNA thio-modification
AKN94_09490	COG1217	gtp-binding protein TYPA
AKN94_09500	COG0494	nUDIX hydrolase
AKN94_09520	COG3098	single-species biofilm formation
AKN94_09535	COG0204	Acyl-transferase
AKN94_09545	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
AKN94_09575	COG3150	esterase
AKN94_09595	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
AKN94_09605	COG3008	intermembrane lipid transfer
AKN94_09605	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
AKN94_09615	COG3830	Belongs to the UPF0237 family
AKN94_09615	COG0560	Phosphoserine phosphatase
AKN94_09640	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AKN94_09650	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AKN94_09655	COG0006	proline dipeptidase activity
AKN94_09660	COG3079	Belongs to the UPF0149 family
AKN94_09675	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
AKN94_09680	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AKN94_09685	COG1129	ABC transporter
AKN94_09685	COG0842	Transport permease protein
AKN94_09690	COG0842	Transport permease protein
AKN94_09700	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
AKN94_09705	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
AKN94_09710	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
AKN94_09715	COG3178	'Phosphotransferase
AKN94_09720	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
AKN94_09725	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
AKN94_09735	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
AKN94_09755	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AKN94_09775	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
AKN94_09780	COG1509	lysine 2,3-aminomutase activity
AKN94_09785	COG0513	Belongs to the DEAD box helicase family
AKN94_09790	COG3530	Putative quorum-sensing-regulated virulence factor
AKN94_09815	COG0142	geranyltranstransferase activity
AKN94_09820	COG1722	exodeoxyribonuclease VII activity
AKN94_09830	COG0456	acetyltransferase
AKN94_09835	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
AKN94_09865	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
AKN94_09870	COG0546	phosphoglycolate phosphatase activity
AKN94_09890	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
AKN94_09895	COG0134	indole-3-glycerol-phosphate synthase activity
AKN94_09900	COG0237	dephospho-CoA kinase activity
AKN94_09910	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
AKN94_09915	COG0471	metal ion transport
AKN94_09915	COG0490	domain, Protein
AKN94_09920	COG1122	ATPase activity
AKN94_09925	COG4120	Belongs to the binding-protein-dependent transport system permease family
AKN94_09935	COG0525	valine-tRNA ligase activity
AKN94_09945	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
AKN94_09955	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
AKN94_09965	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
AKN94_09970	COG0632	four-way junction helicase activity
AKN94_09975	COG2255	four-way junction helicase activity
AKN94_09980	COG0824	Thioesterase
AKN94_10005	COG2885	chlorophyll binding
AKN94_10010	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
AKN94_10020	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
AKN94_10025	COG1970	mechanosensitive ion channel activity
AKN94_10030	COG0142	geranyltranstransferase activity
AKN94_10035	COG0261	This protein binds to 23S rRNA in the presence of protein L20
AKN94_10040	COG0211	Belongs to the bacterial ribosomal protein bL27 family
AKN94_10045	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
AKN94_10050	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
AKN94_10080	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
AKN94_10085	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
AKN94_10090	COG0814	amino acid
AKN94_10100	COG3258	Cytochrome c
AKN94_10105	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
AKN94_10110	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
AKN94_10110	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
AKN94_10115	COG1028	Short-chain dehydrogenase reductase Sdr
AKN94_10135	COG1923	regulation of RNA biosynthetic process
AKN94_10140	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
AKN94_10145	COG0330	HflC and HflK could
AKN94_10150	COG0330	HflC and HflK could
AKN94_10155	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
AKN94_10160	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
AKN94_10185	COG0545	Peptidyl-prolyl cis-trans isomerase
AKN94_10210	COG4221	oxidoreductase activity
AKN94_10210	COG0604	alcohol dehydrogenase
AKN94_10210	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
AKN94_10210	COG3321	synthase
AKN94_10215	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
AKN94_10225	COG0633	Ferredoxin
AKN94_10230	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
AKN94_10235	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
AKN94_10240	COG3313	Fe-S protein
AKN94_10250	COG2813	Specifically methylates the guanine in position
AKN94_10255	COG3118	belongs to the thioredoxin family
AKN94_10260	COG0534	Mate efflux family protein
AKN94_10265	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
AKN94_10270	COG0778	Nitroreductase
AKN94_10285	COG1136	(ABC) transporter
AKN94_10300	COG1067	ATP-dependent peptidase activity
AKN94_10310	COG0789	Transcriptional regulator
AKN94_10325	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
AKN94_10330	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
AKN94_10340	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
AKN94_10345	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
AKN94_10355	COG2226	methyltransferase
AKN94_10365	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
AKN94_10390	COG0688	phosphatidylethanolamine metabolic process
AKN94_10395	COG1162	GTPase activity
AKN94_10400	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
AKN94_10410	COG0802	atpase or kinase
AKN94_10415	COG0860	N-Acetylmuramoyl-L-alanine amidase
AKN94_10435	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
AKN94_10445	COG0545	Peptidyl-prolyl cis-trans isomerase
AKN94_10460	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
AKN94_10470	COG0436	Aminotransferase
AKN94_10480	COG1671	Belongs to the UPF0178 family
AKN94_10485	COG1362	aminopeptidase activity
AKN94_10505	COG0166	Belongs to the GPI family
AKN94_10515	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
AKN94_10520	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
AKN94_10530	COG0617	tRNA 3'-terminal CCA addition
AKN94_10540	COG3118	belongs to the thioredoxin family
AKN94_10545	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
AKN94_10550	COG1965	Belongs to the frataxin family
AKN94_10580	COG1011	Hydrolase
AKN94_10600	COG0815	Transfers the fatty acyl group on membrane lipoproteins
AKN94_10615	COG1702	phosphate starvation-inducible protein PhoH
AKN94_10620	COG1538	Outer membrane efflux protein
AKN94_10625	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
AKN94_10635	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
AKN94_10640	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
AKN94_10645	COG0659	secondary active sulfate transmembrane transporter activity
AKN94_10650	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
AKN94_10655	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
AKN94_10660	COG0723	plastoquinol--plastocyanin reductase activity
AKN94_10665	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
AKN94_10670	COG2857	Cytochrome c1
AKN94_10675	COG0625	glutathione transferase activity
AKN94_10680	COG2969	positive regulation of protein catabolic process
AKN94_10725	COG2211	Major facilitator Superfamily
AKN94_10730	COG3030	protein affecting phage T7 exclusion by the F plasmid
AKN94_10735	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
AKN94_10740	COG0459	protein refolding
AKN94_10745	COG1960	acyl-CoA dehydrogenase activity
AKN94_10750	COG1024	Enoyl-CoA hydratase
AKN94_10765	COG0583	DNA-binding transcription factor activity
AKN94_10775	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AKN94_10785	COG0183	Belongs to the thiolase family
AKN94_10790	COG1024	Enoyl-CoA hydratase
AKN94_10800	COG0786	glutamate:sodium symporter activity
AKN94_10805	COG0442	prolyl-tRNA aminoacylation
AKN94_10820	COG2900	Belongs to the SlyX family
AKN94_10825	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AKN94_10840	COG0668	transmembrane transport
AKN94_10845	COG4942	peptidase
AKN94_10850	COG1570	exodeoxyribonuclease VII activity
AKN94_10855	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
AKN94_10860	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AKN94_10865	COG3162	membrane
AKN94_10875	COG1294	oxidase, subunit
AKN94_10885	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
AKN94_10895	COG1522	sequence-specific DNA binding
AKN94_10905	COG0435	Glutathione S-transferase