locus-tag	class	description
AKN93_00015	COG1132	(ABC) transporter
AKN93_00020	COG3284	Transcriptional regulator
AKN93_00055	COG0435	Glutathione S-transferase
AKN93_00065	COG1522	sequence-specific DNA binding
AKN93_00075	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
AKN93_00085	COG1294	oxidase, subunit
AKN93_00095	COG3162	membrane
AKN93_00100	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AKN93_00105	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
AKN93_00110	COG1570	exodeoxyribonuclease VII activity
AKN93_00115	COG4942	peptidase
AKN93_00120	COG0668	transmembrane transport
AKN93_00135	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AKN93_00140	COG2900	Belongs to the SlyX family
AKN93_00155	COG0442	prolyl-tRNA aminoacylation
AKN93_00160	COG0786	glutamate:sodium symporter activity
AKN93_00170	COG1024	Enoyl-CoA hydratase
AKN93_00175	COG0183	Belongs to the thiolase family
AKN93_00185	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AKN93_00195	COG0583	DNA-binding transcription factor activity
AKN93_00210	COG1024	Enoyl-CoA hydratase
AKN93_00215	COG1960	acyl-CoA dehydrogenase activity
AKN93_00220	COG0459	protein refolding
AKN93_00225	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
AKN93_00230	COG3030	protein affecting phage T7 exclusion by the F plasmid
AKN93_00235	COG2211	Major facilitator Superfamily
AKN93_00280	COG2969	positive regulation of protein catabolic process
AKN93_00285	COG0625	glutathione transferase activity
AKN93_00290	COG2857	Cytochrome c1
AKN93_00295	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
AKN93_00300	COG0723	plastoquinol--plastocyanin reductase activity
AKN93_00305	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
AKN93_00310	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
AKN93_00315	COG0659	secondary active sulfate transmembrane transporter activity
AKN93_00320	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
AKN93_00325	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
AKN93_00335	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
AKN93_00340	COG1538	Outer membrane efflux protein
AKN93_00345	COG1702	phosphate starvation-inducible protein PhoH
AKN93_00360	COG0815	Transfers the fatty acyl group on membrane lipoproteins
AKN93_00380	COG1011	Hydrolase
AKN93_00410	COG1965	Belongs to the frataxin family
AKN93_00415	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
AKN93_00420	COG3118	belongs to the thioredoxin family
AKN93_00430	COG0617	tRNA 3'-terminal CCA addition
AKN93_00440	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
AKN93_00445	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
AKN93_00455	COG0166	Belongs to the GPI family
AKN93_00475	COG1362	aminopeptidase activity
AKN93_00480	COG1671	Belongs to the UPF0178 family
AKN93_00490	COG0436	Aminotransferase
AKN93_00500	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
AKN93_00515	COG0545	Peptidyl-prolyl cis-trans isomerase
AKN93_00525	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
AKN93_00545	COG0860	N-Acetylmuramoyl-L-alanine amidase
AKN93_00550	COG0802	atpase or kinase
AKN93_00560	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
AKN93_00565	COG1162	GTPase activity
AKN93_00570	COG0688	phosphatidylethanolamine metabolic process
AKN93_00595	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
AKN93_00605	COG2226	methyltransferase
AKN93_00615	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
AKN93_00620	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
AKN93_00630	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
AKN93_00635	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
AKN93_00650	COG0789	Transcriptional regulator
AKN93_00660	COG1067	ATP-dependent peptidase activity
AKN93_00675	COG1136	(ABC) transporter
AKN93_00690	COG0778	Nitroreductase
AKN93_00695	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
AKN93_00700	COG0534	Mate efflux family protein
AKN93_00705	COG3118	belongs to the thioredoxin family
AKN93_00710	COG2813	Specifically methylates the guanine in position
AKN93_00720	COG3313	Fe-S protein
AKN93_00725	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
AKN93_00730	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
AKN93_00735	COG0633	Ferredoxin
AKN93_00745	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
AKN93_00750	COG0604	alcohol dehydrogenase
AKN93_00750	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
AKN93_00750	COG3321	synthase
AKN93_00750	COG4221	oxidoreductase activity
AKN93_00775	COG0545	Peptidyl-prolyl cis-trans isomerase
AKN93_00800	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
AKN93_00805	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
AKN93_00810	COG0330	HflC and HflK could
AKN93_00815	COG0330	HflC and HflK could
AKN93_00820	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
AKN93_00825	COG1923	regulation of RNA biosynthetic process
AKN93_00845	COG1028	Short-chain dehydrogenase reductase Sdr
AKN93_00850	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
AKN93_00850	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
AKN93_00855	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
AKN93_00860	COG3258	Cytochrome c
AKN93_00870	COG0814	amino acid
AKN93_00875	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
AKN93_00880	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
AKN93_00910	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
AKN93_00915	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
AKN93_00920	COG0211	Belongs to the bacterial ribosomal protein bL27 family
AKN93_00925	COG0261	This protein binds to 23S rRNA in the presence of protein L20
AKN93_00930	COG0142	geranyltranstransferase activity
AKN93_00935	COG1970	mechanosensitive ion channel activity
AKN93_00940	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
AKN93_00950	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
AKN93_00955	COG2885	chlorophyll binding
AKN93_00980	COG0824	Thioesterase
AKN93_00985	COG2255	four-way junction helicase activity
AKN93_00990	COG0632	four-way junction helicase activity
AKN93_00995	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
AKN93_01005	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
AKN93_01015	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
AKN93_01025	COG0525	valine-tRNA ligase activity
AKN93_01035	COG4120	Belongs to the binding-protein-dependent transport system permease family
AKN93_01040	COG1122	ATPase activity
AKN93_01045	COG0471	metal ion transport
AKN93_01045	COG0490	domain, Protein
AKN93_01050	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
AKN93_01060	COG0237	dephospho-CoA kinase activity
AKN93_01065	COG0134	indole-3-glycerol-phosphate synthase activity
AKN93_01070	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
AKN93_01090	COG0546	phosphoglycolate phosphatase activity
AKN93_01095	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
AKN93_01125	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
AKN93_01130	COG0456	acetyltransferase
AKN93_01140	COG1722	exodeoxyribonuclease VII activity
AKN93_01145	COG0142	geranyltranstransferase activity
AKN93_01170	COG3530	Putative quorum-sensing-regulated virulence factor
AKN93_01175	COG0513	Belongs to the DEAD box helicase family
AKN93_01180	COG1509	lysine 2,3-aminomutase activity
AKN93_01185	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
AKN93_01205	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AKN93_01225	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
AKN93_01235	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
AKN93_01240	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
AKN93_01245	COG3178	'Phosphotransferase
AKN93_01250	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
AKN93_01255	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
AKN93_01260	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
AKN93_01270	COG0842	Transport permease protein
AKN93_01275	COG1129	ABC transporter
AKN93_01275	COG0842	Transport permease protein
AKN93_01280	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AKN93_01285	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
AKN93_01300	COG3079	Belongs to the UPF0149 family
AKN93_01305	COG0006	proline dipeptidase activity
AKN93_01310	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AKN93_01320	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AKN93_01345	COG0560	Phosphoserine phosphatase
AKN93_01345	COG3830	Belongs to the UPF0237 family
AKN93_01355	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
AKN93_01355	COG3008	intermembrane lipid transfer
AKN93_01365	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
AKN93_01385	COG3150	esterase
AKN93_01415	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
AKN93_01425	COG0204	Acyl-transferase
AKN93_01440	COG3098	single-species biofilm formation
AKN93_01460	COG0494	nUDIX hydrolase
AKN93_01470	COG1217	gtp-binding protein TYPA
AKN93_01475	COG0301	tRNA thio-modification
AKN93_01475	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AKN93_01490	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
AKN93_01495	COG1012	belongs to the aldehyde dehydrogenase family
AKN93_01500	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
AKN93_01505	COG0704	Plays a role in the regulation of phosphate uptake
AKN93_01510	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
AKN93_01515	COG0573	inorganic phosphate transmembrane transporter activity
AKN93_01535	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
AKN93_01540	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
AKN93_01575	COG0281	malic enzyme
AKN93_01580	COG0254	rRNA binding
AKN93_01585	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
AKN93_01605	COG0427	acetyl-CoA hydrolase
AKN93_01620	COG1752	Esterase of the alpha-beta hydrolase superfamily
AKN93_01645	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AKN93_01655	COG0427	acetyl-CoA hydrolase
AKN93_01670	COG1752	Esterase of the alpha-beta hydrolase superfamily
AKN93_01695	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AKN93_01705	COG0179	Fumarylacetoacetate (FAA) hydrolase
AKN93_01710	COG0277	FAD linked oxidase domain protein
AKN93_01715	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
AKN93_01725	COG2814	Major facilitator Superfamily
AKN93_01735	COG0753	catalase activity
AKN93_01745	COG0523	cobalamin synthesis protein
AKN93_01770	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
AKN93_01775	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AKN93_01785	COG0267	Belongs to the bacterial ribosomal protein bL33 family
AKN93_01790	COG0227	Belongs to the bacterial ribosomal protein bL28 family
AKN93_01795	COG2003	Belongs to the UPF0758 family
AKN93_01800	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
AKN93_01805	COG0756	dUTP diphosphatase activity
AKN93_01815	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
AKN93_01835	COG1160	GTP binding
AKN93_01860	COG0494	nUDIX hydrolase
AKN93_01870	COG1385	rRNA (uridine-N3-)-methyltransferase activity
AKN93_01880	COG1960	acyl-CoA dehydrogenase activity
AKN93_01900	COG1120	ATPase activity
AKN93_01905	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AKN93_01910	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AKN93_01915	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
AKN93_01930	COG2855	membrane
AKN93_01940	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
AKN93_01940	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
AKN93_01950	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
AKN93_01955	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AKN93_01960	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AKN93_01990	COG0730	response to heat
AKN93_02000	COG1414	Transcriptional regulator
AKN93_02010	COG4771	TonB-dependent receptor
AKN93_02020	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AKN93_02030	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
AKN93_02045	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
AKN93_02045	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
AKN93_02055	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
AKN93_02065	COG1979	alcohol dehydrogenase
AKN93_02070	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
AKN93_02075	COG0583	DNA-binding transcription factor activity
AKN93_02090	COG0814	amino acid
AKN93_02095	COG1368	sulfuric ester hydrolase activity
AKN93_02110	COG4149	molybdate abc transporter
AKN93_02115	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
AKN93_02130	COG1177	transmembrane transport
AKN93_02135	COG1176	ABC-type spermidine putrescine transport system, permease component I
AKN93_02140	COG3842	ATPase activity
AKN93_02155	COG3909	cytochrome
AKN93_02160	COG1652	LysM domain
AKN93_02185	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
AKN93_02195	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
AKN93_02200	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
AKN93_02210	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AKN93_02215	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
AKN93_02220	COG4942	peptidase
AKN93_02225	COG0793	Belongs to the peptidase S41A family
AKN93_02250	COG0131	Imidazoleglycerol-phosphate dehydratase
AKN93_02265	COG1194	a g-specific adenine glycosylase
AKN93_02270	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
AKN93_02295	COG2353	YceI-like domain
AKN93_02300	COG3038	cytochrome b561
AKN93_02305	COG3241	Transfers electrons from cytochrome c551 to cytochrome oxidase
AKN93_02310	COG2193	ferroxidase activity
AKN93_02320	COG0126	phosphoglycerate kinase activity
AKN93_02325	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
AKN93_02335	COG1040	competence protein
AKN93_02350	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
AKN93_02355	COG0156	8-amino-7-oxononanoate synthase activity
AKN93_02360	COG2226	methyltransferase
AKN93_02360	COG1073	alpha beta
AKN93_02380	COG0303	'Molybdopterin
AKN93_02385	COG0521	Mo-molybdopterin cofactor biosynthetic process
AKN93_02435	COG0515	serine threonine protein kinase
AKN93_02435	COG2815	serine threonine protein kinase
AKN93_02500	COG1561	YicC-like family, N-terminal region
AKN93_02505	COG4628	conserved protein (DUF2132)
AKN93_02510	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
AKN93_02540	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
AKN93_02550	COG0826	peptidase U32
AKN93_02560	COG0318	PFAM AMP-dependent synthetase and ligase
AKN93_02580	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
AKN93_02585	COG0569	domain protein
AKN93_02590	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
AKN93_02595	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
AKN93_02600	COG0242	peptide deformylase activity
AKN93_02610	COG0758	DNA mediated transformation
AKN93_02615	COG0009	L-threonylcarbamoyladenylate synthase
AKN93_02625	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
AKN93_02630	COG2239	Acts as a magnesium transporter
AKN93_02635	COG1285	pathogenesis
AKN93_02640	COG0003	Pfam Anion-transporting ATPase
AKN93_02650	COG1966	Carbon starvation protein
AKN93_02675	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
AKN93_02680	COG0730	response to heat
AKN93_02685	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
AKN93_02690	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
AKN93_02710	COG3154	lipid carrier protein
AKN93_02715	COG0826	peptidase U32
AKN93_02720	COG0826	peptidase U32
AKN93_02725	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
AKN93_02740	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
AKN93_02755	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
AKN93_02760	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
AKN93_02765	COG0252	asparaginase activity
AKN93_02795	COG1132	(ABC) transporter
AKN93_02800	COG0617	tRNA 3'-terminal CCA addition
AKN93_02800	COG3620	sequence-specific DNA binding
AKN93_02800	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
AKN93_02810	COG0789	Transcriptional regulator
AKN93_02845	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
AKN93_02850	COG0129	dihydroxy-acid dehydratase activity
AKN93_02865	COG3135	benzoate transporter
AKN93_02870	COG1178	ABC-type Fe3 transport system permease component
AKN93_02875	COG0404	The glycine cleavage system catalyzes the degradation of glycine
AKN93_02885	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
AKN93_02885	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
AKN93_02895	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
AKN93_02910	COG0742	ribosomal rna small subunit methyltransferase
AKN93_02915	COG0612	Peptidase, M16
AKN93_02920	COG0612	Peptidase, M16
AKN93_02930	COG0552	protein localization to endoplasmic reticulum
AKN93_02935	COG2884	Cell division ATP-binding protein ftsE
AKN93_02940	COG2177	Part of the ABC transporter FtsEX involved in
AKN93_02950	COG2431	L-lysine efflux transmembrane transporter activity
AKN93_02955	COG0833	amino acid
AKN93_02965	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
AKN93_02970	COG0513	Belongs to the DEAD box helicase family
AKN93_02975	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
AKN93_02980	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
AKN93_03035	COG0700	Nucleoside recognition
AKN93_03040	COG3023	N-Acetylmuramoyl-L-alanine amidase
AKN93_03050	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
AKN93_03055	COG0355	proton-transporting ATP synthase activity, rotational mechanism
AKN93_03060	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
AKN93_03065	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
AKN93_03070	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
AKN93_03075	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
AKN93_03080	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
AKN93_03090	COG0356	it plays a direct role in the translocation of protons across the membrane
AKN93_03100	COG1475	DNA binding
AKN93_03105	COG1192	Involved in chromosome partitioning
AKN93_03120	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
AKN93_03130	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
AKN93_03135	COG0594	ribonuclease P activity
AKN93_03140	COG0230	Belongs to the bacterial ribosomal protein bL34 family
AKN93_03175	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
AKN93_03190	COG1758	RNA polymerase activity
AKN93_03195	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
AKN93_03215	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
AKN93_03225	COG2363	Small membrane protein
AKN93_03235	COG2022	thiamine diphosphate biosynthetic process
AKN93_03240	COG0220	tRNA (guanine-N7-)-methyltransferase activity
AKN93_03260	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
AKN93_03265	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
AKN93_03275	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
AKN93_03290	COG0248	Ppx GppA phosphatase
AKN93_03300	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
AKN93_03305	COG0592	DNA-directed DNA polymerase activity
AKN93_03310	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
AKN93_03320	COG0642	Histidine kinase
AKN93_03335	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AKN93_03345	COG0159	tryptophan synthase activity
AKN93_03350	COG0133	tryptophan synthase activity
AKN93_03360	COG1960	acyl-CoA dehydrogenase activity
AKN93_03370	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
AKN93_03375	COG0583	DNA-binding transcription factor activity
AKN93_03380	COG3384	dioxygenase
AKN93_03390	COG3038	cytochrome b561
AKN93_03395	COG1289	transmembrane transporter activity
AKN93_03400	COG1944	ATP diphosphatase activity
AKN93_03405	COG2207	Transcriptional regulator
AKN93_03415	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
AKN93_03425	COG0303	'Molybdopterin
AKN93_03430	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
AKN93_03440	COG0642	Histidine kinase
AKN93_03445	COG0745	RESPONSE REGULATOR receiver
AKN93_03450	COG1368	sulfuric ester hydrolase activity
AKN93_03480	COG0084	hydrolase, TatD family'
AKN93_03490	COG1451	nucleotide metabolic process
AKN93_03495	COG0071	Belongs to the small heat shock protein (HSP20) family
AKN93_03515	COG0175	sulfate reduction
AKN93_03520	COG1648	precorrin-2 dehydrogenase activity
AKN93_03520	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
AKN93_03540	COG0306	phosphate transporter
AKN93_03545	COG1392	Phosphate transport regulator
AKN93_03555	COG0330	HflC and HflK could
AKN93_03590	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
AKN93_03600	COG0540	Belongs to the ATCase OTCase family
AKN93_03610	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
AKN93_03615	COG3204	pilus organization
AKN93_03625	COG0494	nUDIX hydrolase
AKN93_03630	COG1011	Hydrolase
AKN93_03660	COG1872	DUF167
AKN93_03665	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
AKN93_03670	COG2813	Specifically methylates the guanine in position
AKN93_03670	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
AKN93_03685	COG0635	Involved in the biosynthesis of porphyrin-containing compound
AKN93_03700	COG0583	DNA-binding transcription factor activity
AKN93_03705	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
AKN93_03720	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
AKN93_03740	COG0751	glycine-tRNA ligase activity
AKN93_03745	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
AKN93_03765	COG0347	Belongs to the P(II) protein family
AKN93_03780	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
AKN93_03785	COG3161	chorismate lyase activity
AKN93_03800	COG3258	Cytochrome c
AKN93_03805	COG2863	cytochrome
AKN93_03810	COG0606	chelatase, subunit chli
AKN93_03820	COG1028	Short-chain dehydrogenase reductase Sdr
AKN93_03825	COG1028	Short-chain dehydrogenase reductase Sdr
AKN93_03830	COG0019	diaminopimelate decarboxylase activity
AKN93_03835	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
AKN93_03855	COG4771	TonB-dependent receptor
AKN93_03865	COG4191	Histidine kinase
AKN93_03870	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
AKN93_03875	COG1519	Transferase
AKN93_03885	COG0501	Belongs to the peptidase M48B family
AKN93_03895	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AKN93_03900	COG3047	cAMP biosynthetic process
AKN93_03905	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
AKN93_03910	COG1490	D-aminoacyl-tRNA deacylase activity
AKN93_03915	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
AKN93_03920	COG0488	(ABC) transporter
AKN93_03930	COG2918	glutathione biosynthetic process
AKN93_03935	COG2183	response to ionizing radiation
AKN93_03955	COG0735	belongs to the Fur family
AKN93_03960	COG1121	(ABC) transporter
AKN93_03965	COG1108	ABC-type Mn2 Zn2 transport systems permease components
AKN93_03980	COG2011	ABC-type metal ion transport system permease component
AKN93_03990	COG1765	OsmC-like protein
AKN93_03995	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
AKN93_04000	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
AKN93_04005	COG0537	adenosine 5'-monophosphoramidase activity
AKN93_04010	COG1981	membrane
AKN93_04015	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
AKN93_04020	COG0316	Belongs to the HesB IscA family
AKN93_04025	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
AKN93_04030	COG0739	heme binding
AKN93_04035	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
AKN93_04065	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
AKN93_04065	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
AKN93_04070	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
AKN93_04095	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
AKN93_04115	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
AKN93_04120	COG0081	regulation of translation
AKN93_04125	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
AKN93_04130	COG0222	ribosome binding
AKN93_04135	COG0085	RNA polymerase activity
AKN93_04145	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
AKN93_04150	COG0049	tRNA binding
AKN93_04155	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
AKN93_04160	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
AKN93_04165	COG0051	transcription antitermination factor activity, RNA binding
AKN93_04170	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
AKN93_04175	COG0088	Forms part of the polypeptide exit tunnel
AKN93_04185	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
AKN93_04190	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
AKN93_04195	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
AKN93_04200	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
AKN93_04210	COG0255	Belongs to the universal ribosomal protein uL29 family
AKN93_04215	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
AKN93_04220	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
AKN93_04225	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
AKN93_04235	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
AKN93_04240	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
AKN93_04245	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
AKN93_04250	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
AKN93_04255	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
AKN93_04260	COG1841	ribosomal large subunit assembly
AKN93_04265	COG0200	Binds to the 23S rRNA
AKN93_04280	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
AKN93_04285	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
AKN93_04290	COG0202	RNA polymerase activity
AKN93_04295	COG0203	ribosomal protein L17
AKN93_04305	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
AKN93_04325	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
AKN93_04340	COG2081	HI0933 family
AKN93_04350	COG3263	regulation of cellular component size
AKN93_04355	COG3264	Mechanosensitive ion channel
AKN93_04355	COG1196	nuclear chromosome segregation
AKN93_04360	COG0676	glucose-6-phosphate 1-epimerase activity
AKN93_04385	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
AKN93_04390	COG2176	DNA-directed DNA polymerase activity
AKN93_04400	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
AKN93_04425	COG0697	spore germination
AKN93_04430	COG1917	Cupin 2, conserved barrel domain protein
AKN93_04430	COG2207	Transcriptional regulator
AKN93_04435	COG0113	porphobilinogen synthase activity
AKN93_04440	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
AKN93_04455	COG1960	acyl-CoA dehydrogenase activity
AKN93_04465	COG0318	PFAM AMP-dependent synthetase and ligase
AKN93_04470	COG4191	Histidine kinase
AKN93_04475	COG4566	intracellular signal transduction
AKN93_04480	COG0617	tRNA 3'-terminal CCA addition
AKN93_04505	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
AKN93_04520	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
AKN93_04525	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
AKN93_04530	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
AKN93_04545	COG1346	cytolysis
AKN93_04550	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
AKN93_04550	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
AKN93_04555	COG4989	oxidoreductase activity
AKN93_04565	COG1301	dicarboxylic acid transport
AKN93_04580	COG4659	FMN binding
AKN93_04585	COG4658	electron transport chain
AKN93_04595	COG2878	Part of a membrane complex involved in electron transport
AKN93_04600	COG4657	Part of a membrane complex involved in electron transport
AKN93_04610	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AKN93_04630	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
AKN93_04635	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
AKN93_04645	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
AKN93_04650	COG0501	Belongs to the peptidase M48B family
AKN93_04660	COG1643	Atp-dependent helicase
AKN93_04685	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
AKN93_04690	COG1802	Transcriptional regulator
AKN93_04700	COG0372	Belongs to the citrate synthase family
AKN93_04705	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
AKN93_04715	COG2264	protein methyltransferase activity
AKN93_04725	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AKN93_04735	COG0318	PFAM AMP-dependent synthetase and ligase
AKN93_04740	COG0183	Belongs to the thiolase family
AKN93_04770	COG2873	o-acetylhomoserine
AKN93_04780	COG1690	Belongs to the RtcB family
AKN93_04785	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AKN93_04800	COG0288	reversible hydration of carbon dioxide
AKN93_04815	COG0022	dehydrogenase e1 component
AKN93_04820	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
AKN93_04840	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
AKN93_04850	COG1028	Short-chain dehydrogenase reductase Sdr
AKN93_04855	COG0671	phosphoesterase, PA-phosphatase related
AKN93_04860	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
AKN93_04865	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
AKN93_04870	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
AKN93_04880	COG1607	acyl-coa hydrolase
AKN93_04890	COG0861	Integral membrane protein TerC family
AKN93_04900	COG0488	(ABC) transporter
AKN93_04925	COG0181	hydroxymethylbilane synthase activity
AKN93_04950	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
AKN93_04955	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
AKN93_04960	COG3956	TIGRFAM MazG family protein
AKN93_04965	COG3122	Protein conserved in bacteria
AKN93_04975	COG3258	Cytochrome c
AKN93_04980	COG0268	Binds directly to 16S ribosomal RNA
AKN93_04985	COG0728	peptidoglycan biosynthetic process
AKN93_04990	COG0196	riboflavin kinase activity
AKN93_04995	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
AKN93_05005	COG1047	Peptidyl-prolyl cis-trans
AKN93_05010	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
AKN93_05025	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
AKN93_05040	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
AKN93_05065	COG4574	serine-type endopeptidase inhibitor activity
AKN93_05075	COG0322	excinuclease ABC activity
AKN93_05090	COG3100	YcgL domain-containing protein
AKN93_05095	COG1555	photosystem II stabilization
AKN93_05110	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
AKN93_05115	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
AKN93_05125	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AKN93_05155	COG0714	Associated with various cellular activities
AKN93_05160	COG0564	pseudouridine synthase activity
AKN93_05165	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
AKN93_05170	COG2894	cell division
AKN93_05175	COG0850	regulation of cytokinetic process
AKN93_05180	COG1560	Kdo2-lipid A biosynthetic process
AKN93_05190	COG2853	Lipoprotein
AKN93_05205	COG0489	protein tyrosine kinase activity
AKN93_05210	COG1278	Cold shock
AKN93_05215	COG0717	Belongs to the dCTP deaminase family
AKN93_05240	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
AKN93_05270	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AKN93_05280	COG0859	PFAM glycosyl transferase family 9
AKN93_05285	COG0859	PFAM glycosyl transferase family 9
AKN93_05290	COG0438	transferase activity, transferring glycosyl groups
AKN93_05315	COG2192	nodulation
AKN93_05320	COG0438	transferase activity, transferring glycosyl groups
AKN93_05350	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
AKN93_05365	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
AKN93_05390	COG0438	transferase activity, transferring glycosyl groups
AKN93_05395	COG0438	transferase activity, transferring glycosyl groups
AKN93_05415	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
AKN93_05420	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
AKN93_05450	COG1252	NADH dehydrogenase
AKN93_05465	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
AKN93_05470	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
AKN93_05485	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
AKN93_05490	COG1077	Cell shape determining protein MreB Mrl
AKN93_05495	COG1792	Involved in formation and maintenance of cell shape
AKN93_05505	COG0424	maF-like protein
AKN93_05510	COG1530	ribonuclease E activity
AKN93_05520	COG0497	DNA recombination
AKN93_05525	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
AKN93_05530	COG0443	Heat shock 70 kDa protein
AKN93_05535	COG0484	heat shock protein binding
AKN93_05540	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
AKN93_05560	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
AKN93_05585	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
AKN93_05590	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AKN93_05595	COG0149	triose-phosphate isomerase activity
AKN93_05610	COG0779	Required for maturation of 30S ribosomal subunits
AKN93_05615	COG0195	Participates in both transcription termination and antitermination
AKN93_05620	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
AKN93_05625	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
AKN93_05630	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
AKN93_05635	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
AKN93_05640	COG1185	polyribonucleotide nucleotidyltransferase activity
AKN93_05650	COG0501	Belongs to the peptidase M48B family
AKN93_05655	COG3091	SprT-like family
AKN93_05670	COG0436	Aminotransferase
AKN93_05695	COG1104	cysteine desulfurase activity
AKN93_05705	COG0316	Belongs to the HesB IscA family
AKN93_05710	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
AKN93_05750	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
AKN93_05755	COG0124	histidyl-tRNA synthetase
AKN93_05770	COG1160	GTP binding
AKN93_05805	COG0446	pyridine nucleotide-disulphide oxidoreductase
AKN93_05805	COG1902	pentaerythritol trinitrate reductase activity
AKN93_05810	COG1530	ribonuclease E activity
AKN93_05830	COG0424	maF-like protein
AKN93_05835	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
AKN93_05845	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
AKN93_05850	COG0336	Belongs to the RNA methyltransferase TrmD family
AKN93_05860	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
AKN93_05870	COG2823	Periplasmic or secreted lipoprotein
AKN93_05880	COG0792	nuclease activity
AKN93_05885	COG3107	peptidoglycan biosynthetic process
AKN93_05895	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
AKN93_05910	COG3223	Belongs to the PsiE family
AKN93_05920	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
AKN93_05930	COG3028	Belongs to the UPF0307 family
AKN93_05935	COG0312	modulator of DNA gyrase
AKN93_05940	COG0028	Belongs to the TPP enzyme family
AKN93_05955	COG1183	phosphatidylcholine synthase activity
AKN93_05985	COG0500	methyltransferase
AKN93_06005	COG0135	phosphoribosylanthranilate isomerase activity
AKN93_06010	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
AKN93_06015	COG0285	dihydrofolate synthase activity
AKN93_06025	COG1286	toxin biosynthetic process
AKN93_06040	COG2925	Exonuclease
AKN93_06055	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AKN93_06060	COG0544	peptidyl-prolyl cis-trans isomerase activity
AKN93_06070	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
AKN93_06075	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
AKN93_06085	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
AKN93_06090	COG3089	Belongs to the UPF0270 family
AKN93_06095	COG0431	NADPH-dependent FMN reductase
AKN93_06100	COG2056	Na+-H+ antiporter family
AKN93_06105	COG2837	iron assimilation
AKN93_06110	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
AKN93_06120	COG2914	Belongs to the UPF0125 (RnfH) family
AKN93_06125	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
AKN93_06135	COG2326	polyphosphate kinase activity
AKN93_06140	COG3081	Nucleoid-associated protein
AKN93_06155	COG3171	Protein conserved in bacteria
AKN93_06165	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AKN93_06185	COG2610	gluconate transmembrane transporter activity
AKN93_06195	COG2084	Dehydrogenase
AKN93_06200	COG3622	Belongs to the hyi family
AKN93_06245	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
AKN93_06250	COG0352	thiamine-phosphate diphosphorylase activity
AKN93_06255	COG0351	phosphomethylpyrimidine kinase
AKN93_06255	COG0352	thiamine-phosphate diphosphorylase activity
AKN93_06270	COG0495	leucyl-tRNA aminoacylation
AKN93_06280	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
AKN93_06280	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AKN93_06290	COG1196	nuclear chromosome segregation
AKN93_06295	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
AKN93_06300	COG1546	Belongs to the CinA family
AKN93_06310	COG2137	regulation of response to DNA damage stimulus
AKN93_06325	COG0513	Belongs to the DEAD box helicase family
AKN93_06330	COG1946	Acyl-CoA thioesterase
AKN93_06365	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
AKN93_06370	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
AKN93_06375	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
AKN93_06380	COG0772	Belongs to the SEDS family
AKN93_06390	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
AKN93_06395	COG1181	Belongs to the D-alanine--D-alanine ligase family
AKN93_06410	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
AKN93_06415	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
AKN93_06425	COG0653	protein targeting
AKN93_06435	COG0494	nUDIX hydrolase
AKN93_06440	COG2096	Adenosyltransferase
AKN93_06450	COG1666	GTP binding
AKN93_06455	COG0322	excinuclease ABC activity
AKN93_06465	COG0557	exoribonuclease II activity
AKN93_06470	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AKN93_06475	COG0360	Binds together with S18 to 16S ribosomal RNA
AKN93_06490	COG0359	binds to the 23S rRNA
AKN93_06495	COG0305	Participates in initiation and elongation during chromosome replication
AKN93_06515	COG0138	bifunctional purine biosynthesis protein purh
AKN93_06545	COG2135	peptidase activity
AKN93_06555	COG1660	Displays ATPase and GTPase activities
AKN93_06570	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
AKN93_06595	COG3201	nicotinamide mononucleotide transporter
AKN93_06605	COG1846	Transcriptional regulator
AKN93_06615	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
AKN93_06630	COG1805	sodium ion transport
AKN93_06655	COG1477	protein flavinylation
AKN93_06665	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AKN93_06675	COG4591	ABC-type transport system involved in lipoprotein release permease component
AKN93_06690	COG0436	Aminotransferase
AKN93_06695	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AKN93_06705	COG4536	flavin adenine dinucleotide binding
AKN93_06715	COG1399	metal-binding, possibly nucleic acid-binding protein
AKN93_06720	COG0333	Belongs to the bacterial ribosomal protein bL32 family
AKN93_06725	COG0416	fatty acid biosynthetic process
AKN93_06740	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
AKN93_06745	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
AKN93_06750	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
AKN93_06755	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
AKN93_06760	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
AKN93_06775	COG0084	hydrolase, TatD family'
AKN93_06780	COG1643	Atp-dependent helicase
AKN93_06785	COG0826	peptidase U32
AKN93_06795	COG1214	PFAM Peptidase M22, glycoprotease
AKN93_06800	COG0742	ribosomal rna small subunit methyltransferase
AKN93_06820	COG0564	pseudouridine synthase activity
AKN93_06835	COG3720	iron ion transport
AKN93_06845	COG0848	biopolymer transport protein
AKN93_06850	COG4558	Periplasmic binding protein
AKN93_06855	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AKN93_06860	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
AKN93_06880	COG0165	Argininosuccinate lyase
AKN93_06890	COG0530	calcium, potassium:sodium antiporter activity
AKN93_06895	COG0471	metal ion transport
AKN93_06900	COG0513	Belongs to the DEAD box helicase family
AKN93_06920	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
AKN93_06935	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
AKN93_06995	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AKN93_07015	COG3206	protein involved in exopolysaccharide biosynthesis
AKN93_07015	COG0489	protein tyrosine kinase activity
AKN93_07035	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
AKN93_07060	COG0438	transferase activity, transferring glycosyl groups
AKN93_07065	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
AKN93_07075	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
AKN93_07080	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
AKN93_07105	COG1968	undecaprenyl-diphosphatase activity
AKN93_07135	COG1252	NADH dehydrogenase
AKN93_07145	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
AKN93_07155	COG0148	phosphopyruvate hydratase activity
AKN93_07160	COG2877	3-deoxy-8-phosphooctulonate synthase activity
AKN93_07165	COG0504	CTP synthase activity
AKN93_07180	COG2951	lytic endotransglycosylase activity
AKN93_07190	COG1686	Belongs to the peptidase S11 family
AKN93_07200	COG0321	lipoyl(octanoyl) transferase activity
AKN93_07205	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
AKN93_07215	COG2264	protein methyltransferase activity
AKN93_07240	COG0730	response to heat
AKN93_07245	COG0514	ATP-dependent DNA helicase (RecQ)
AKN93_07250	COG2076	Multidrug Resistance protein
AKN93_07260	COG5592	hemerythrin HHE cation binding domain
AKN93_07265	COG0602	queuosine metabolic process
AKN93_07270	COG0720	synthase
AKN93_07290	COG2823	Periplasmic or secreted lipoprotein
AKN93_07295	COG0363	glucosamine-6-phosphate deaminase activity
AKN93_07310	COG2967	ApaG domain
AKN93_07315	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
AKN93_07320	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AKN93_07330	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
AKN93_07340	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
AKN93_07350	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
AKN93_07355	COG0795	lipopolysaccharide-transporting ATPase activity
AKN93_07360	COG0795	lipopolysaccharide-transporting ATPase activity
AKN93_07365	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
AKN93_07370	COG2027	D-alanyl-D-alanine carboxypeptidase
AKN93_07380	COG2847	Copper chaperone PCu(A)C
AKN93_07385	COG1278	Cold shock
AKN93_07390	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
AKN93_07395	COG0542	response to heat
AKN93_07410	COG2030	dehydratase
AKN93_07415	COG0318	PFAM AMP-dependent synthetase and ligase
AKN93_07420	COG0589	response to stress
AKN93_07425	COG1252	NADH dehydrogenase
AKN93_07435	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
AKN93_07445	COG0148	phosphopyruvate hydratase activity
AKN93_07450	COG2877	3-deoxy-8-phosphooctulonate synthase activity
AKN93_07455	COG0504	CTP synthase activity
AKN93_07480	COG1199	ATP-dependent helicase activity
AKN93_07490	COG0167	dihydroorotate dehydrogenase activity
AKN93_07495	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AKN93_07505	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AKN93_07515	COG3243	poly(R)-hydroxyalkanoic acid synthase
AKN93_07525	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
AKN93_07540	COG0800	Aldolase
AKN93_07555	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
AKN93_07560	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
AKN93_07565	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
AKN93_07580	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
AKN93_07585	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
AKN93_07600	COG2989	Protein conserved in bacteria
AKN93_07605	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
AKN93_07615	COG0291	Belongs to the bacterial ribosomal protein bL35 family
AKN93_07620	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
AKN93_07625	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
AKN93_07630	COG0072	phenylalanine-tRNA ligase activity
AKN93_07635	COG0776	regulation of translation
AKN93_07670	COG0693	protein deglycase activity
AKN93_07680	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
AKN93_07705	COG1262	PFAM Formylglycine-generating sulfatase enzyme
AKN93_07705	COG0515	serine threonine protein kinase
AKN93_07755	COG0542	response to heat
AKN93_07765	COG0189	ligase activity
AKN93_07780	COG2223	nitrite transmembrane transporter activity
AKN93_07800	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
AKN93_07810	COG2321	neutral zinc metallopeptidase
AKN93_07815	COG4988	ABC transporter
AKN93_07820	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
AKN93_07830	COG0328	RNA-DNA hybrid ribonuclease activity
AKN93_07835	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
AKN93_07905	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
AKN93_07915	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
AKN93_07920	COG1115	amino acid carrier protein
AKN93_07940	COG0425	Belongs to the sulfur carrier protein TusA family
AKN93_07945	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
AKN93_07950	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
AKN93_07970	COG0308	aminopeptidase N
AKN93_07985	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
AKN93_08000	COG1335	isochorismatase
AKN93_08005	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
AKN93_08010	COG4181	ATPase activity
AKN93_08025	COG0402	S-adenosylhomocysteine deaminase activity
AKN93_08065	COG0418	dihydroorotase activity
AKN93_08070	COG0137	argininosuccinate synthase activity
AKN93_08075	COG0346	lactoylglutathione lyase activity
AKN93_08090	COG1028	Short-chain dehydrogenase reductase Sdr
AKN93_08100	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
AKN93_08105	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
AKN93_08110	COG2252	PERMEase
AKN93_08125	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
AKN93_08130	COG0066	3-isopropylmalate dehydratase activity
AKN93_08155	COG0668	transmembrane transport
AKN93_08160	COG4133	protoheme IX ABC transporter activity
AKN93_08185	COG1138	Cytochrome C-type biogenesis protein
AKN93_08205	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
AKN93_08210	COG1360	Flagellar Motor Protein
AKN93_08225	COG3133	Outer membrane lipoprotein
AKN93_08270	COG1025	Belongs to the peptidase M16 family
AKN93_08275	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
AKN93_08275	COG0116	Belongs to the methyltransferase superfamily
AKN93_08300	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
AKN93_08330	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
AKN93_08335	COG1074	ATP-dependent DNA helicase activity
AKN93_08340	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
AKN93_08345	COG0393	Putative heavy-metal-binding
AKN93_08355	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
AKN93_08380	COG1024	Enoyl-CoA hydratase
AKN93_08395	COG2204	response regulator
AKN93_08400	COG4191	Histidine kinase
AKN93_08400	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AKN93_08430	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AKN93_08435	COG0481	GTPase activity
AKN93_08445	COG0571	ribonuclease III activity
AKN93_08450	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
AKN93_08455	COG1381	Involved in DNA repair and RecF pathway recombination
AKN93_08460	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
AKN93_08480	COG1131	(ABC) transporter
AKN93_08485	COG0842	Transport permease protein
AKN93_08490	COG0791	NLP P60 protein
AKN93_08495	COG0791	NLP P60 protein
AKN93_08500	COG0133	tryptophan synthase activity
AKN93_08510	COG0642	Histidine kinase
AKN93_08520	COG0745	RESPONSE REGULATOR receiver
AKN93_08525	COG2350	Protein conserved in bacteria
AKN93_08530	COG2917	probably involved in intracellular septation
AKN93_08535	COG0613	PHP domain protein
AKN93_08540	COG0009	L-threonylcarbamoyladenylate synthase
AKN93_08545	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
AKN93_08550	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
AKN93_08560	COG0535	radical SAM domain protein
AKN93_08570	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
AKN93_08625	COG2205	protein histidine kinase activity
AKN93_08625	COG0784	Response regulator, receiver
AKN93_08645	COG1397	ADP-ribosylglycohydrolase
AKN93_08650	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
AKN93_08660	COG0419	ATPase involved in DNA repair
AKN93_08665	COG0420	3'-5' exonuclease activity
AKN93_08675	COG0628	permease
AKN93_08685	COG0625	glutathione transferase activity
AKN93_08705	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
AKN93_08715	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
AKN93_08725	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AKN93_08730	COG2814	Major facilitator Superfamily
AKN93_08750	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
AKN93_08755	COG0585	pseudouridine synthase activity
AKN93_08760	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
AKN93_08770	COG2911	Protein conserved in bacteria
AKN93_08775	COG0729	surface antigen
AKN93_08780	COG0708	Exodeoxyribonuclease III
AKN93_08785	COG3781	membrane
AKN93_08790	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
AKN93_08795	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
AKN93_08800	COG1858	cytochrome C peroxidase
AKN93_08810	COG3409	Peptidoglycan-binding domain 1 protein
AKN93_08810	COG0860	N-Acetylmuramoyl-L-alanine amidase
AKN93_08840	COG0037	tRNA processing
AKN93_08860	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
AKN93_08870	COG0560	Phosphoserine phosphatase
AKN93_08890	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AKN93_08905	COG4953	penicillin-binding protein 1C
AKN93_08915	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
AKN93_08920	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
AKN93_08925	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
AKN93_08930	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
AKN93_08935	COG5007	Belongs to the BolA IbaG family
AKN93_08955	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
AKN93_08960	COG1127	ABC transporter
AKN93_08970	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
AKN93_08980	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
AKN93_08985	COG1137	ATPase activity
AKN93_09000	COG1132	(ABC) transporter
AKN93_09025	COG0730	response to heat
AKN93_09040	COG1024	Enoyl-CoA hydratase
AKN93_09045	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
AKN93_09055	COG2010	Cytochrome c
AKN93_09060	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AKN93_09060	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
AKN93_09065	COG0023	Translation Initiation Factor
AKN93_09070	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AKN93_09080	COG2119	membrane
AKN93_09085	COG5394	Polyhydroxyalkanoate synthesis repressor PhaR
AKN93_09090	COG0675	Transposase, IS605 OrfB family
AKN93_09110	COG0500	methyltransferase
AKN93_09130	COG1335	isochorismatase
AKN93_09190	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AKN93_09195	COG2373	Large extracellular alpha-helical protein
AKN93_09210	COG0433	COG0433 Predicted ATPase
AKN93_09215	COG0788	formyltetrahydrofolate deformylase activity
AKN93_09220	COG2853	Lipoprotein
AKN93_09225	COG0215	cysteine-tRNA ligase activity
AKN93_09230	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AKN93_09235	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
AKN93_09240	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AKN93_09245	COG2031	fatty acid transporter
AKN93_09250	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
AKN93_09255	COG3115	cell septum assembly
AKN93_09260	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
AKN93_09265	COG2824	Alkylphosphonate utilization operon protein PhnA
AKN93_09275	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
AKN93_09280	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
AKN93_09285	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
AKN93_09290	COG0077	Prephenate dehydratase
AKN93_09290	COG1605	Chorismate mutase
AKN93_09305	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
AKN93_09310	COG1132	(ABC) transporter
AKN93_09330	COG0271	Belongs to the BolA IbaG family
AKN93_09360	COG0848	biopolymer transport protein
AKN93_09365	COG0811	peptide transport
AKN93_09370	COG0811	peptide transport
AKN93_09380	COG0121	glutamine amidotransferase
AKN93_09390	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
AKN93_09415	COG0582	viral genome integration into host DNA
AKN93_09475	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
AKN93_09510	COG0730	response to heat
AKN93_09515	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
AKN93_09520	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
AKN93_09530	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
AKN93_09535	COG4208	sulfate ABC transporter
AKN93_09545	COG0469	pyruvate kinase activity
AKN93_09550	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
AKN93_09555	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
AKN93_09560	COG3842	ATPase activity
AKN93_09580	COG0730	response to heat
AKN93_09585	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
AKN93_09590	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
AKN93_09600	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
AKN93_09605	COG4208	sulfate ABC transporter
AKN93_09615	COG0469	pyruvate kinase activity
AKN93_09620	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
AKN93_09625	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
AKN93_09630	COG3842	ATPase activity
AKN93_09650	COG2885	chlorophyll binding
AKN93_09660	COG0427	acetyl-CoA hydrolase
AKN93_09685	COG0513	Belongs to the DEAD box helicase family
AKN93_09700	COG2212	antiporter activity
AKN93_09710	COG0651	ATP synthesis coupled electron transport
AKN93_09715	COG1006	Multisubunit Na H antiporter MnhC subunit
AKN93_09720	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
AKN93_09720	COG2111	Na H antiporter
AKN93_09725	COG0604	alcohol dehydrogenase
AKN93_09740	COG0556	nucleotide-excision repair
AKN93_09750	COG1136	(ABC) transporter
AKN93_09765	COG2996	Protein conserved in bacteria
AKN93_09775	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AKN93_09780	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AKN93_09785	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
AKN93_09790	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AKN93_09800	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
AKN93_09810	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
AKN93_09820	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
AKN93_09825	COG0233	cytoplasmic translational termination
AKN93_09830	COG0528	UMP kinase activity
AKN93_09835	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
AKN93_09840	COG0052	Belongs to the universal ribosomal protein uS2 family
AKN93_09845	COG0024	Methionine aminopeptidase
AKN93_09850	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
AKN93_09855	COG1393	Belongs to the ArsC family
AKN93_09860	COG2171	N-acyltransferase activity
AKN93_09865	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
AKN93_09870	COG2166	iron-sulfur cluster assembly
AKN93_09905	COG2814	Major facilitator Superfamily
AKN93_09915	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
AKN93_09920	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
AKN93_09930	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
AKN93_09935	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
AKN93_09945	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
AKN93_09950	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
AKN93_09965	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
AKN93_09980	COG0604	alcohol dehydrogenase
AKN93_09985	COG0616	signal peptide processing
AKN93_10010	COG0812	UDP-N-acetylmuramate dehydrogenase activity
AKN93_10015	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
AKN93_10020	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
AKN93_10025	COG2835	tetraacyldisaccharide 4'-kinase activity
AKN93_10030	COG1663	tetraacyldisaccharide 4'-kinase activity
AKN93_10035	COG0658	competence protein
AKN93_10035	COG2333	competence protein COMEC
AKN93_10045	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
AKN93_10055	COG0511	ligase activity, forming carbon-carbon bonds
AKN93_10055	COG5016	pyruvate
AKN93_10060	COG3630	sodium ion export across plasma membrane
AKN93_10065	COG2239	Acts as a magnesium transporter
AKN93_10095	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
AKN93_10105	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
AKN93_10115	COG0037	tRNA processing
AKN93_10120	COG2814	Major facilitator Superfamily
AKN93_10125	COG0284	orotidine-5'-phosphate decarboxylase activity
AKN93_10130	COG0114	fumarate hydratase activity
AKN93_10135	COG0730	response to heat
AKN93_10160	COG1862	Preprotein translocase
AKN93_10170	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
AKN93_10180	COG2259	Doxx family
AKN93_10185	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
AKN93_10190	COG2366	antibiotic biosynthetic process
AKN93_10195	COG2885	chlorophyll binding
AKN93_10210	COG0400	carboxylic ester hydrolase activity
AKN93_10215	COG0513	Belongs to the DEAD box helicase family
AKN93_10220	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
AKN93_10230	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AKN93_10240	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
AKN93_10245	COG0425	Belongs to the sulfur carrier protein TusA family
AKN93_10250	COG4783	chaperone-mediated protein folding
AKN93_10255	COG2855	membrane
AKN93_10260	COG2814	Major facilitator Superfamily
AKN93_10265	COG2356	endonuclease I
AKN93_10275	COG1272	protein, Hemolysin III
AKN93_10290	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
AKN93_10300	COG0456	acetyltransferase
AKN93_10325	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
AKN93_10330	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AKN93_10335	COG1120	ATPase activity
AKN93_10345	COG1492	cobalamin metabolic process
AKN93_10350	COG0778	Nitroreductase
AKN93_10370	COG0583	DNA-binding transcription factor activity
AKN93_10410	COG0318	PFAM AMP-dependent synthetase and ligase
AKN93_10415	COG1960	acyl-CoA dehydrogenase activity
AKN93_10420	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
AKN93_10425	COG1024	Enoyl-CoA hydratase
AKN93_10425	COG1250	3-hydroxyacyl-CoA dehydrogenase
AKN93_10450	COG0789	Transcriptional regulator
AKN93_10455	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
AKN93_10480	COG0045	succinate-CoA ligase (ADP-forming) activity
AKN93_10500	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
AKN93_10515	COG2009	succinate dehydrogenase
AKN93_10535	COG2084	Dehydrogenase
AKN93_10545	COG3278	Belongs to the heme-copper respiratory oxidase family
AKN93_10560	COG2010	Cytochrome c
AKN93_10575	COG2217	Heavy metal translocating P-type atpase
AKN93_10600	COG2175	clavaminate synthase activity
AKN93_10605	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AKN93_10610	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
AKN93_10615	COG4521	taurine ABC transporter
AKN93_10620	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
AKN93_10625	COG0492	ferredoxin-NADP+ reductase activity
AKN93_10645	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AKN93_10665	COG0776	regulation of translation
AKN93_10670	COG0316	Belongs to the HesB IscA family
AKN93_10670	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
AKN93_10675	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
AKN93_10695	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
AKN93_10700	COG2840	Smr protein MutS2
AKN93_10715	COG0741	lytic transglycosylase activity
AKN93_10715	COG0739	heme binding
AKN93_10715	COG1196	nuclear chromosome segregation
AKN93_10730	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
AKN93_10735	COG0018	arginyl-trna synthetase
AKN93_10750	COG4206	TonB-dependent receptor
AKN93_10760	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
AKN93_10770	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
AKN93_10780	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
AKN93_10780	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
AKN93_10785	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
AKN93_10795	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
AKN93_10815	COG1309	transcriptional regulator
AKN93_10840	COG0183	Belongs to the thiolase family
AKN93_10845	COG1250	3-hydroxyacyl-CoA dehydrogenase
AKN93_10845	COG1024	Enoyl-CoA hydratase
AKN93_10850	COG0589	response to stress
AKN93_10855	COG0405	Gamma-glutamyltransferase
AKN93_10860	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
AKN93_10865	COG0488	(ABC) transporter
AKN93_10880	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
AKN93_10885	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
AKN93_10895	COG0741	lytic transglycosylase activity
AKN93_10895	COG1388	LysM domain
AKN93_10905	COG4166	transmembrane transport
AKN93_10910	COG4174	ABC transporter (Permease)
AKN93_10915	COG4239	(ABC) transporter, permease
AKN93_10920	COG4172	Belongs to the ABC transporter superfamily
AKN93_10935	COG0753	catalase activity
AKN93_10940	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
AKN93_10945	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
AKN93_10950	COG0482	sulfurtransferase activity
AKN93_10955	COG2915	High frequency lysogenization protein hflD homolog
AKN93_10960	COG0697	spore germination
AKN93_10970	COG2850	peptidyl-arginine hydroxylation
AKN93_10975	COG2153	protein acetylation
AKN93_10995	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
AKN93_11005	COG2226	methyltransferase
AKN93_11020	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
AKN93_11035	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
AKN93_11040	COG2860	membrane
AKN93_11045	COG0644	oxidoreductase