locus-tag	class	description
AKN92_00015	COG0189	ligase activity
AKN92_00030	COG2223	nitrite transmembrane transporter activity
AKN92_00050	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
AKN92_00060	COG2321	neutral zinc metallopeptidase
AKN92_00065	COG4988	ABC transporter
AKN92_00070	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
AKN92_00080	COG0328	RNA-DNA hybrid ribonuclease activity
AKN92_00085	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
AKN92_00155	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
AKN92_00165	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
AKN92_00170	COG1115	amino acid carrier protein
AKN92_00190	COG0425	Belongs to the sulfur carrier protein TusA family
AKN92_00195	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
AKN92_00200	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
AKN92_00220	COG0308	aminopeptidase N
AKN92_00235	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
AKN92_00250	COG1335	isochorismatase
AKN92_00255	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
AKN92_00260	COG4181	ATPase activity
AKN92_00275	COG0402	S-adenosylhomocysteine deaminase activity
AKN92_00315	COG0418	dihydroorotase activity
AKN92_00320	COG0137	argininosuccinate synthase activity
AKN92_00325	COG0346	lactoylglutathione lyase activity
AKN92_00340	COG1028	Short-chain dehydrogenase reductase Sdr
AKN92_00350	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
AKN92_00355	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
AKN92_00360	COG2252	PERMEase
AKN92_00375	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
AKN92_00380	COG0066	3-isopropylmalate dehydratase activity
AKN92_00405	COG0668	transmembrane transport
AKN92_00410	COG4133	protoheme IX ABC transporter activity
AKN92_00435	COG1138	Cytochrome C-type biogenesis protein
AKN92_00455	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
AKN92_00475	COG3133	Outer membrane lipoprotein
AKN92_00520	COG1025	Belongs to the peptidase M16 family
AKN92_00525	COG0116	Belongs to the methyltransferase superfamily
AKN92_00525	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
AKN92_00550	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
AKN92_00585	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
AKN92_00590	COG1074	ATP-dependent DNA helicase activity
AKN92_00595	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
AKN92_00600	COG0393	Putative heavy-metal-binding
AKN92_00610	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
AKN92_00635	COG1024	Enoyl-CoA hydratase
AKN92_00650	COG2204	response regulator
AKN92_00655	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AKN92_00655	COG4191	Histidine kinase
AKN92_00685	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AKN92_00690	COG0481	GTPase activity
AKN92_00700	COG0571	ribonuclease III activity
AKN92_00705	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
AKN92_00710	COG1381	Involved in DNA repair and RecF pathway recombination
AKN92_00715	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
AKN92_00735	COG1131	(ABC) transporter
AKN92_00740	COG0842	Transport permease protein
AKN92_00745	COG0791	NLP P60 protein
AKN92_00750	COG0791	NLP P60 protein
AKN92_00755	COG0133	tryptophan synthase activity
AKN92_00765	COG0642	Histidine kinase
AKN92_00775	COG0745	RESPONSE REGULATOR receiver
AKN92_00780	COG2350	Protein conserved in bacteria
AKN92_00785	COG2917	probably involved in intracellular septation
AKN92_00790	COG0613	PHP domain protein
AKN92_00795	COG0009	L-threonylcarbamoyladenylate synthase
AKN92_00800	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
AKN92_00805	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
AKN92_00815	COG0535	radical SAM domain protein
AKN92_00825	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
AKN92_00880	COG2205	protein histidine kinase activity
AKN92_00880	COG0784	Response regulator, receiver
AKN92_00900	COG1397	ADP-ribosylglycohydrolase
AKN92_00905	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
AKN92_00915	COG0419	ATPase involved in DNA repair
AKN92_00920	COG0420	3'-5' exonuclease activity
AKN92_00930	COG0628	permease
AKN92_00940	COG0625	glutathione transferase activity
AKN92_00960	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
AKN92_00970	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
AKN92_00980	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AKN92_00985	COG2814	Major facilitator Superfamily
AKN92_01005	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
AKN92_01010	COG0585	pseudouridine synthase activity
AKN92_01015	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
AKN92_01025	COG2911	Protein conserved in bacteria
AKN92_01030	COG0729	surface antigen
AKN92_01035	COG0708	Exodeoxyribonuclease III
AKN92_01040	COG3781	membrane
AKN92_01045	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
AKN92_01050	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
AKN92_01075	COG0037	tRNA processing
AKN92_01095	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
AKN92_01105	COG0560	Phosphoserine phosphatase
AKN92_01130	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AKN92_01145	COG4953	penicillin-binding protein 1C
AKN92_01155	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
AKN92_01160	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
AKN92_01165	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
AKN92_01170	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
AKN92_01175	COG5007	Belongs to the BolA IbaG family
AKN92_01195	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
AKN92_01200	COG1127	ABC transporter
AKN92_01210	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
AKN92_01220	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
AKN92_01225	COG1137	ATPase activity
AKN92_01240	COG1132	(ABC) transporter
AKN92_01265	COG0730	response to heat
AKN92_01280	COG1024	Enoyl-CoA hydratase
AKN92_01285	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
AKN92_01295	COG2010	Cytochrome c
AKN92_01300	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AKN92_01300	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
AKN92_01305	COG0023	Translation Initiation Factor
AKN92_01310	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AKN92_01315	COG0069	glutamate synthase activity
AKN92_01320	COG2119	membrane
AKN92_01325	COG5394	Polyhydroxyalkanoate synthesis repressor PhaR
AKN92_01330	COG0675	Transposase, IS605 OrfB family
AKN92_01355	COG1335	isochorismatase
AKN92_01415	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AKN92_01420	COG2373	Large extracellular alpha-helical protein
AKN92_01435	COG0433	COG0433 Predicted ATPase
AKN92_01440	COG0788	formyltetrahydrofolate deformylase activity
AKN92_01445	COG2853	Lipoprotein
AKN92_01450	COG0215	cysteine-tRNA ligase activity
AKN92_01455	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AKN92_01460	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
AKN92_01465	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AKN92_01470	COG2031	fatty acid transporter
AKN92_01475	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
AKN92_01480	COG3115	cell septum assembly
AKN92_01485	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
AKN92_01490	COG2824	Alkylphosphonate utilization operon protein PhnA
AKN92_01500	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
AKN92_01505	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
AKN92_01510	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
AKN92_01515	COG0077	Prephenate dehydratase
AKN92_01515	COG1605	Chorismate mutase
AKN92_01530	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
AKN92_01535	COG1132	(ABC) transporter
AKN92_01555	COG0271	Belongs to the BolA IbaG family
AKN92_01585	COG0848	biopolymer transport protein
AKN92_01590	COG0811	peptide transport
AKN92_01595	COG0811	peptide transport
AKN92_01605	COG0121	glutamine amidotransferase
AKN92_01615	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
AKN92_01650	COG3135	benzoate transporter
AKN92_01665	COG0730	response to heat
AKN92_01670	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
AKN92_01675	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
AKN92_01685	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
AKN92_01690	COG4208	sulfate ABC transporter
AKN92_01700	COG0469	pyruvate kinase activity
AKN92_01705	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
AKN92_01710	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
AKN92_01715	COG3842	ATPase activity
AKN92_01735	COG2885	chlorophyll binding
AKN92_01745	COG0427	acetyl-CoA hydrolase
AKN92_01770	COG0513	Belongs to the DEAD box helicase family
AKN92_01785	COG2212	antiporter activity
AKN92_01795	COG0651	ATP synthesis coupled electron transport
AKN92_01800	COG1006	Multisubunit Na H antiporter MnhC subunit
AKN92_01805	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
AKN92_01805	COG2111	Na H antiporter
AKN92_01810	COG0604	alcohol dehydrogenase
AKN92_01825	COG0556	nucleotide-excision repair
AKN92_01835	COG1136	(ABC) transporter
AKN92_01850	COG2996	Protein conserved in bacteria
AKN92_01860	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AKN92_01865	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AKN92_01870	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
AKN92_01875	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AKN92_01895	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
AKN92_01905	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
AKN92_01910	COG0233	cytoplasmic translational termination
AKN92_01915	COG0528	UMP kinase activity
AKN92_01920	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
AKN92_01925	COG0052	Belongs to the universal ribosomal protein uS2 family
AKN92_01930	COG0024	Methionine aminopeptidase
AKN92_01935	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
AKN92_01940	COG1393	Belongs to the ArsC family
AKN92_01945	COG2171	N-acyltransferase activity
AKN92_01950	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
AKN92_01955	COG2166	iron-sulfur cluster assembly
AKN92_01990	COG2814	Major facilitator Superfamily
AKN92_02000	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
AKN92_02005	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
AKN92_02015	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
AKN92_02020	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
AKN92_02030	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
AKN92_02035	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
AKN92_02050	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
AKN92_02065	COG0604	alcohol dehydrogenase
AKN92_02070	COG0616	signal peptide processing
AKN92_02095	COG0812	UDP-N-acetylmuramate dehydrogenase activity
AKN92_02100	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
AKN92_02105	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
AKN92_02110	COG2835	tetraacyldisaccharide 4'-kinase activity
AKN92_02115	COG1663	tetraacyldisaccharide 4'-kinase activity
AKN92_02120	COG0658	competence protein
AKN92_02120	COG2333	competence protein COMEC
AKN92_02130	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
AKN92_02160	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
AKN92_02170	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
AKN92_02180	COG0037	tRNA processing
AKN92_02185	COG2814	Major facilitator Superfamily
AKN92_02190	COG0284	orotidine-5'-phosphate decarboxylase activity
AKN92_02195	COG0114	fumarate hydratase activity
AKN92_02200	COG0730	response to heat
AKN92_02225	COG1862	Preprotein translocase
AKN92_02235	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
AKN92_02245	COG2259	Doxx family
AKN92_02250	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
AKN92_02255	COG2366	antibiotic biosynthetic process
AKN92_02260	COG2885	chlorophyll binding
AKN92_02275	COG0400	carboxylic ester hydrolase activity
AKN92_02280	COG0513	Belongs to the DEAD box helicase family
AKN92_02285	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
AKN92_02295	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AKN92_02305	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
AKN92_02310	COG0425	Belongs to the sulfur carrier protein TusA family
AKN92_02315	COG4783	chaperone-mediated protein folding
AKN92_02325	COG2814	Major facilitator Superfamily
AKN92_02330	COG2356	endonuclease I
AKN92_02340	COG1272	protein, Hemolysin III
AKN92_02355	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
AKN92_02365	COG0456	acetyltransferase
AKN92_02390	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
AKN92_02395	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AKN92_02400	COG1120	ATPase activity
AKN92_02410	COG1492	cobalamin metabolic process
AKN92_02415	COG0778	Nitroreductase
AKN92_02440	COG0583	DNA-binding transcription factor activity
AKN92_02480	COG0318	PFAM AMP-dependent synthetase and ligase
AKN92_02485	COG1960	acyl-CoA dehydrogenase activity
AKN92_02490	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
AKN92_02495	COG1024	Enoyl-CoA hydratase
AKN92_02495	COG1250	3-hydroxyacyl-CoA dehydrogenase
AKN92_02520	COG0789	Transcriptional regulator
AKN92_02525	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
AKN92_02570	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
AKN92_02585	COG2009	succinate dehydrogenase
AKN92_02605	COG2084	Dehydrogenase
AKN92_02615	COG3278	Belongs to the heme-copper respiratory oxidase family
AKN92_02630	COG2010	Cytochrome c
AKN92_02645	COG2217	Heavy metal translocating P-type atpase
AKN92_02665	COG0741	lytic transglycosylase activity
AKN92_02670	COG2175	clavaminate synthase activity
AKN92_02675	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AKN92_02680	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
AKN92_02685	COG4521	taurine ABC transporter
AKN92_02690	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
AKN92_02695	COG0492	ferredoxin-NADP+ reductase activity
AKN92_02715	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AKN92_02735	COG0776	regulation of translation
AKN92_02740	COG0316	Belongs to the HesB IscA family
AKN92_02740	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
AKN92_02745	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
AKN92_02765	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
AKN92_02785	COG0739	heme binding
AKN92_02785	COG1196	nuclear chromosome segregation
AKN92_02785	COG0741	lytic transglycosylase activity
AKN92_02800	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
AKN92_02805	COG0018	arginyl-trna synthetase
AKN92_02820	COG4206	TonB-dependent receptor
AKN92_02830	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
AKN92_02840	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
AKN92_02850	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
AKN92_02850	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
AKN92_02855	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
AKN92_02865	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
AKN92_02875	COG1070	Carbohydrate kinase
AKN92_02880	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
AKN92_02890	COG2207	Transcriptional regulator
AKN92_02915	COG0183	Belongs to the thiolase family
AKN92_02920	COG1250	3-hydroxyacyl-CoA dehydrogenase
AKN92_02920	COG1024	Enoyl-CoA hydratase
AKN92_02925	COG0589	response to stress
AKN92_02930	COG0405	Gamma-glutamyltransferase
AKN92_02935	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
AKN92_02940	COG0488	(ABC) transporter
AKN92_02955	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
AKN92_02960	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
AKN92_02970	COG0741	lytic transglycosylase activity
AKN92_02970	COG1388	LysM domain
AKN92_02980	COG4166	transmembrane transport
AKN92_02985	COG4174	ABC transporter (Permease)
AKN92_02990	COG4239	(ABC) transporter, permease
AKN92_02995	COG4172	Belongs to the ABC transporter superfamily
AKN92_03010	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
AKN92_03015	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
AKN92_03020	COG0482	sulfurtransferase activity
AKN92_03025	COG2915	High frequency lysogenization protein hflD homolog
AKN92_03030	COG0697	spore germination
AKN92_03040	COG2850	peptidyl-arginine hydroxylation
AKN92_03045	COG2153	protein acetylation
AKN92_03060	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
AKN92_03070	COG2226	methyltransferase
AKN92_03085	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
AKN92_03100	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
AKN92_03105	COG2860	membrane
AKN92_03145	COG0285	dihydrofolate synthase activity
AKN92_03150	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
AKN92_03155	COG0135	phosphoribosylanthranilate isomerase activity
AKN92_03175	COG0500	methyltransferase
AKN92_03205	COG1183	phosphatidylcholine synthase activity
AKN92_03220	COG0028	Belongs to the TPP enzyme family
AKN92_03225	COG0312	modulator of DNA gyrase
AKN92_03230	COG3028	Belongs to the UPF0307 family
AKN92_03235	COG0312	modulator of DNA gyrase
AKN92_03240	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
AKN92_03250	COG3223	Belongs to the PsiE family
AKN92_03265	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
AKN92_03275	COG3107	peptidoglycan biosynthetic process
AKN92_03280	COG0792	nuclease activity
AKN92_03290	COG2823	Periplasmic or secreted lipoprotein
AKN92_03300	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
AKN92_03310	COG0336	Belongs to the RNA methyltransferase TrmD family
AKN92_03315	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
AKN92_03325	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
AKN92_03330	COG0424	maF-like protein
AKN92_03355	COG1530	ribonuclease E activity
AKN92_03360	COG1902	pentaerythritol trinitrate reductase activity
AKN92_03360	COG0446	pyridine nucleotide-disulphide oxidoreductase
AKN92_03395	COG1160	GTP binding
AKN92_03410	COG0124	histidyl-tRNA synthetase
AKN92_03415	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
AKN92_03455	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
AKN92_03460	COG0316	Belongs to the HesB IscA family
AKN92_03470	COG1104	cysteine desulfurase activity
AKN92_03495	COG0436	Aminotransferase
AKN92_03510	COG3091	SprT-like family
AKN92_03515	COG0501	Belongs to the peptidase M48B family
AKN92_03525	COG1185	polyribonucleotide nucleotidyltransferase activity
AKN92_03530	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
AKN92_03535	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
AKN92_03540	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
AKN92_03545	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
AKN92_03550	COG0195	Participates in both transcription termination and antitermination
AKN92_03555	COG0779	Required for maturation of 30S ribosomal subunits
AKN92_03570	COG0149	triose-phosphate isomerase activity
AKN92_03575	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AKN92_03580	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
AKN92_03605	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
AKN92_03625	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
AKN92_03630	COG0484	heat shock protein binding
AKN92_03635	COG0443	Heat shock 70 kDa protein
AKN92_03640	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
AKN92_03645	COG0497	DNA recombination
AKN92_03655	COG1530	ribonuclease E activity
AKN92_03660	COG0424	maF-like protein
AKN92_03675	COG1077	Cell shape determining protein MreB Mrl
AKN92_03680	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
AKN92_03695	COG1252	NADH dehydrogenase
AKN92_03720	COG1215	transferase activity, transferring glycosyl groups
AKN92_03735	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
AKN92_03745	COG2244	polysaccharide biosynthetic process
AKN92_03765	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
AKN92_03790	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
AKN92_03795	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
AKN92_03795	COG2755	lipolytic protein G-D-S-L family
AKN92_03805	COG0438	transferase activity, transferring glycosyl groups
AKN92_03825	COG0438	transferase activity, transferring glycosyl groups
AKN92_03830	COG2192	nodulation
AKN92_03855	COG0438	transferase activity, transferring glycosyl groups
AKN92_03860	COG0859	PFAM glycosyl transferase family 9
AKN92_03865	COG0859	PFAM glycosyl transferase family 9
AKN92_03875	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AKN92_03905	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
AKN92_03950	COG0582	viral genome integration into host DNA
AKN92_03990	COG1595	DNA-templated transcription, initiation
AKN92_04005	COG0798	PFAM Bile acid sodium symporter
AKN92_04010	COG0431	NADPH-dependent FMN reductase
AKN92_04020	COG0659	secondary active sulfate transmembrane transporter activity
AKN92_04070	COG0717	Belongs to the dCTP deaminase family
AKN92_04075	COG1278	Cold shock
AKN92_04080	COG0489	protein tyrosine kinase activity
AKN92_04095	COG2853	Lipoprotein
AKN92_04105	COG1560	Kdo2-lipid A biosynthetic process
AKN92_04110	COG0850	regulation of cytokinetic process
AKN92_04115	COG2894	cell division
AKN92_04120	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
AKN92_04125	COG0564	pseudouridine synthase activity
AKN92_04130	COG0714	Associated with various cellular activities
AKN92_04160	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AKN92_04170	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
AKN92_04175	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
AKN92_04180	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
AKN92_04190	COG1555	photosystem II stabilization
AKN92_04195	COG3100	YcgL domain-containing protein
AKN92_04210	COG0322	excinuclease ABC activity
AKN92_04220	COG4574	serine-type endopeptidase inhibitor activity
AKN92_04245	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
AKN92_04250	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
AKN92_04250	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
AKN92_04260	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
AKN92_04275	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
AKN92_04280	COG1047	Peptidyl-prolyl cis-trans
AKN92_04290	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
AKN92_04295	COG0196	riboflavin kinase activity
AKN92_04300	COG0728	peptidoglycan biosynthetic process
AKN92_04305	COG0268	Binds directly to 16S ribosomal RNA
AKN92_04310	COG3258	Cytochrome c
AKN92_04320	COG3122	Protein conserved in bacteria
AKN92_04325	COG3956	TIGRFAM MazG family protein
AKN92_04330	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
AKN92_04335	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
AKN92_04360	COG0181	hydroxymethylbilane synthase activity
AKN92_04385	COG0488	(ABC) transporter
AKN92_04395	COG0861	Integral membrane protein TerC family
AKN92_04405	COG1607	acyl-coa hydrolase
AKN92_04415	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
AKN92_04420	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
AKN92_04425	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
AKN92_04430	COG0671	phosphoesterase, PA-phosphatase related
AKN92_04435	COG1028	Short-chain dehydrogenase reductase Sdr
AKN92_04445	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
AKN92_04465	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
AKN92_04470	COG0022	dehydrogenase e1 component
AKN92_04485	COG0288	reversible hydration of carbon dioxide
AKN92_04500	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AKN92_04505	COG1690	Belongs to the RtcB family
AKN92_04515	COG2873	o-acetylhomoserine
AKN92_04545	COG0183	Belongs to the thiolase family
AKN92_04550	COG0318	PFAM AMP-dependent synthetase and ligase
AKN92_04560	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AKN92_04570	COG2264	protein methyltransferase activity
AKN92_04580	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
AKN92_04585	COG0372	Belongs to the citrate synthase family
AKN92_04595	COG1802	Transcriptional regulator
AKN92_04600	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
AKN92_04625	COG1643	Atp-dependent helicase
AKN92_04635	COG0501	Belongs to the peptidase M48B family
AKN92_04640	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
AKN92_04650	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
AKN92_04655	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
AKN92_04675	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AKN92_04685	COG4657	Part of a membrane complex involved in electron transport
AKN92_04690	COG2878	Part of a membrane complex involved in electron transport
AKN92_04700	COG4658	electron transport chain
AKN92_04705	COG4659	FMN binding
AKN92_04720	COG1301	dicarboxylic acid transport
AKN92_04730	COG4989	oxidoreductase activity
AKN92_04735	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
AKN92_04735	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
AKN92_04740	COG1346	cytolysis
AKN92_04755	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
AKN92_04760	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
AKN92_04765	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
AKN92_04780	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
AKN92_04805	COG0617	tRNA 3'-terminal CCA addition
AKN92_04810	COG4566	intracellular signal transduction
AKN92_04815	COG4191	Histidine kinase
AKN92_04820	COG0318	PFAM AMP-dependent synthetase and ligase
AKN92_04830	COG1960	acyl-CoA dehydrogenase activity
AKN92_04845	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
AKN92_04850	COG0113	porphobilinogen synthase activity
AKN92_04855	COG2207	Transcriptional regulator
AKN92_04855	COG1917	Cupin 2, conserved barrel domain protein
AKN92_04860	COG0697	spore germination
AKN92_04885	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
AKN92_04895	COG2176	DNA-directed DNA polymerase activity
AKN92_04900	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
AKN92_04925	COG0676	glucose-6-phosphate 1-epimerase activity
AKN92_04930	COG3264	Mechanosensitive ion channel
AKN92_04930	COG1196	nuclear chromosome segregation
AKN92_04935	COG3263	regulation of cellular component size
AKN92_04945	COG2081	HI0933 family
AKN92_04960	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
AKN92_04980	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
AKN92_04990	COG0203	ribosomal protein L17
AKN92_04995	COG0202	RNA polymerase activity
AKN92_05000	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
AKN92_05005	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
AKN92_05020	COG0200	Binds to the 23S rRNA
AKN92_05025	COG1841	ribosomal large subunit assembly
AKN92_05030	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
AKN92_05035	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
AKN92_05040	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
AKN92_05045	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
AKN92_05050	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
AKN92_05060	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
AKN92_05065	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
AKN92_05070	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
AKN92_05075	COG0255	Belongs to the universal ribosomal protein uL29 family
AKN92_05080	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
AKN92_05085	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
AKN92_05090	COG0739	heme binding
AKN92_05095	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
AKN92_05100	COG0316	Belongs to the HesB IscA family
AKN92_05105	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
AKN92_05110	COG1981	membrane
AKN92_05115	COG0537	adenosine 5'-monophosphoramidase activity
AKN92_05120	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
AKN92_05125	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
AKN92_05130	COG1765	OsmC-like protein
AKN92_05140	COG2011	ABC-type metal ion transport system permease component
AKN92_05155	COG1108	ABC-type Mn2 Zn2 transport systems permease components
AKN92_05160	COG1121	(ABC) transporter
AKN92_05165	COG0735	belongs to the Fur family
AKN92_05170	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
AKN92_05185	COG2183	response to ionizing radiation
AKN92_05190	COG2918	glutathione biosynthetic process
AKN92_05200	COG0488	(ABC) transporter
AKN92_05205	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
AKN92_05210	COG1490	D-aminoacyl-tRNA deacylase activity
AKN92_05215	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
AKN92_05220	COG3047	cAMP biosynthetic process
AKN92_05225	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AKN92_05235	COG0501	Belongs to the peptidase M48B family
AKN92_05245	COG1519	Transferase
AKN92_05250	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
AKN92_05255	COG4191	Histidine kinase
AKN92_05265	COG4771	TonB-dependent receptor
AKN92_05290	COG0019	diaminopimelate decarboxylase activity
AKN92_05295	COG1028	Short-chain dehydrogenase reductase Sdr
AKN92_05300	COG1028	Short-chain dehydrogenase reductase Sdr
AKN92_05310	COG0606	chelatase, subunit chli
AKN92_05315	COG2863	cytochrome
AKN92_05320	COG3258	Cytochrome c
AKN92_05335	COG3161	chorismate lyase activity
AKN92_05340	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
AKN92_05355	COG0347	Belongs to the P(II) protein family
AKN92_05375	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
AKN92_05380	COG0751	glycine-tRNA ligase activity
AKN92_05400	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
AKN92_05415	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
AKN92_05420	COG0583	DNA-binding transcription factor activity
AKN92_05435	COG0635	Involved in the biosynthesis of porphyrin-containing compound
AKN92_05450	COG2813	Specifically methylates the guanine in position
AKN92_05450	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
AKN92_05455	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
AKN92_05460	COG1872	DUF167
AKN92_05490	COG1011	Hydrolase
AKN92_05495	COG0494	nUDIX hydrolase
AKN92_05505	COG3204	pilus organization
AKN92_05510	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
AKN92_05520	COG0540	Belongs to the ATCase OTCase family
AKN92_05530	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
AKN92_05545	COG0745	RESPONSE REGULATOR receiver
AKN92_05590	COG0330	HflC and HflK could
AKN92_05600	COG1392	Phosphate transport regulator
AKN92_05605	COG0306	phosphate transporter
AKN92_05630	COG0523	cobalamin synthesis protein
AKN92_05660	COG0071	Belongs to the small heat shock protein (HSP20) family
AKN92_05665	COG1451	nucleotide metabolic process
AKN92_05675	COG0084	hydrolase, TatD family'
AKN92_05705	COG1368	sulfuric ester hydrolase activity
AKN92_05710	COG0745	RESPONSE REGULATOR receiver
AKN92_05715	COG0642	Histidine kinase
AKN92_05720	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
AKN92_05730	COG2207	Transcriptional regulator
AKN92_05735	COG1944	ATP diphosphatase activity
AKN92_05740	COG1289	transmembrane transporter activity
AKN92_05745	COG3038	cytochrome b561
AKN92_05755	COG3384	dioxygenase
AKN92_05760	COG0583	DNA-binding transcription factor activity
AKN92_05765	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
AKN92_05775	COG1960	acyl-CoA dehydrogenase activity
AKN92_05785	COG0133	tryptophan synthase activity
AKN92_05790	COG0159	tryptophan synthase activity
AKN92_05800	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AKN92_05815	COG0642	Histidine kinase
AKN92_05825	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
AKN92_05830	COG0592	DNA-directed DNA polymerase activity
AKN92_05835	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
AKN92_05845	COG0248	Ppx GppA phosphatase
AKN92_05860	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
AKN92_05875	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
AKN92_05880	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
AKN92_05900	COG0220	tRNA (guanine-N7-)-methyltransferase activity
AKN92_05905	COG2022	thiamine diphosphate biosynthetic process
AKN92_05915	COG2363	Small membrane protein
AKN92_05925	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
AKN92_05945	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
AKN92_05950	COG1758	RNA polymerase activity
AKN92_05965	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
AKN92_06005	COG0230	Belongs to the bacterial ribosomal protein bL34 family
AKN92_06010	COG0594	ribonuclease P activity
AKN92_06015	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
AKN92_06025	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
AKN92_06040	COG1192	Involved in chromosome partitioning
AKN92_06045	COG1475	DNA binding
AKN92_06055	COG0356	it plays a direct role in the translocation of protons across the membrane
AKN92_06065	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
AKN92_06070	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
AKN92_06075	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
AKN92_06080	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
AKN92_06085	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
AKN92_06090	COG0355	proton-transporting ATP synthase activity, rotational mechanism
AKN92_06095	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
AKN92_06105	COG3023	N-Acetylmuramoyl-L-alanine amidase
AKN92_06110	COG0700	Nucleoside recognition
AKN92_06165	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
AKN92_06170	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
AKN92_06175	COG0513	Belongs to the DEAD box helicase family
AKN92_06180	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
AKN92_06200	COG0833	amino acid
AKN92_06205	COG2431	L-lysine efflux transmembrane transporter activity
AKN92_06215	COG2177	Part of the ABC transporter FtsEX involved in
AKN92_06220	COG2884	Cell division ATP-binding protein ftsE
AKN92_06225	COG0552	protein localization to endoplasmic reticulum
AKN92_06230	COG0612	Peptidase, M16
AKN92_06235	COG0612	Peptidase, M16
AKN92_06240	COG0742	ribosomal rna small subunit methyltransferase
AKN92_06255	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
AKN92_06265	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
AKN92_06265	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
AKN92_06275	COG0404	The glycine cleavage system catalyzes the degradation of glycine
AKN92_06280	COG1178	ABC-type Fe3 transport system permease component
AKN92_06285	COG3135	benzoate transporter
AKN92_06300	COG0129	dihydroxy-acid dehydratase activity
AKN92_06305	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
AKN92_06320	COG0789	Transcriptional regulator
AKN92_06330	COG3620	sequence-specific DNA binding
AKN92_06330	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
AKN92_06330	COG0617	tRNA 3'-terminal CCA addition
AKN92_06335	COG1132	(ABC) transporter
AKN92_06365	COG0252	asparaginase activity
AKN92_06370	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
AKN92_06375	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
AKN92_06390	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
AKN92_06405	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
AKN92_06410	COG0826	peptidase U32
AKN92_06415	COG0826	peptidase U32
AKN92_06420	COG3154	lipid carrier protein
AKN92_06445	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
AKN92_06450	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
AKN92_06455	COG0730	response to heat
AKN92_06460	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
AKN92_06485	COG1966	Carbon starvation protein
AKN92_06495	COG0003	Pfam Anion-transporting ATPase
AKN92_06500	COG1285	pathogenesis
AKN92_06505	COG2239	Acts as a magnesium transporter
AKN92_06510	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
AKN92_06520	COG0009	L-threonylcarbamoyladenylate synthase
AKN92_06525	COG0758	DNA mediated transformation
AKN92_06535	COG0242	peptide deformylase activity
AKN92_06540	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
AKN92_06545	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
AKN92_06550	COG0569	domain protein
AKN92_06555	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
AKN92_06565	COG0318	PFAM AMP-dependent synthetase and ligase
AKN92_06575	COG0826	peptidase U32
AKN92_06585	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
AKN92_06610	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
AKN92_06615	COG4628	conserved protein (DUF2132)
AKN92_06620	COG1561	YicC-like family, N-terminal region
AKN92_06635	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
AKN92_06645	COG1196	nuclear chromosome segregation
AKN92_06695	COG1073	alpha beta
AKN92_06695	COG2226	methyltransferase
AKN92_06700	COG0156	8-amino-7-oxononanoate synthase activity
AKN92_06705	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
AKN92_06720	COG1040	competence protein
AKN92_06730	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
AKN92_06735	COG0126	phosphoglycerate kinase activity
AKN92_06745	COG2193	ferroxidase activity
AKN92_06750	COG3241	Transfers electrons from cytochrome c551 to cytochrome oxidase
AKN92_06755	COG3038	cytochrome b561
AKN92_06760	COG2353	YceI-like domain
AKN92_06775	COG1858	cytochrome C peroxidase
AKN92_06790	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
AKN92_06795	COG1194	a g-specific adenine glycosylase
AKN92_06810	COG0131	Imidazoleglycerol-phosphate dehydratase
AKN92_06835	COG0793	Belongs to the peptidase S41A family
AKN92_06840	COG4942	peptidase
AKN92_06845	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
AKN92_06850	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AKN92_06860	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
AKN92_06865	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
AKN92_06875	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
AKN92_06900	COG1652	LysM domain
AKN92_06905	COG3909	cytochrome
AKN92_06920	COG3842	ATPase activity
AKN92_06925	COG1176	ABC-type spermidine putrescine transport system, permease component I
AKN92_06930	COG1177	transmembrane transport
AKN92_06950	COG0814	amino acid
AKN92_06965	COG0583	DNA-binding transcription factor activity
AKN92_06970	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
AKN92_06975	COG1979	alcohol dehydrogenase
AKN92_06985	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
AKN92_06995	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
AKN92_06995	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
AKN92_07010	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
AKN92_07020	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AKN92_07030	COG4771	TonB-dependent receptor
AKN92_07040	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
AKN92_07045	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AKN92_07050	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AKN92_07055	COG1120	ATPase activity
AKN92_07070	COG1960	acyl-CoA dehydrogenase activity
AKN92_07080	COG1385	rRNA (uridine-N3-)-methyltransferase activity
AKN92_07090	COG0494	nUDIX hydrolase
AKN92_07115	COG1160	GTP binding
AKN92_07135	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
AKN92_07145	COG0756	dUTP diphosphatase activity
AKN92_07150	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
AKN92_07155	COG2003	Belongs to the UPF0758 family
AKN92_07160	COG0227	Belongs to the bacterial ribosomal protein bL28 family
AKN92_07165	COG0267	Belongs to the bacterial ribosomal protein bL33 family
AKN92_07175	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AKN92_07180	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
AKN92_07205	COG0523	cobalamin synthesis protein
AKN92_07215	COG0753	catalase activity
AKN92_07225	COG2814	Major facilitator Superfamily
AKN92_07235	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
AKN92_07240	COG0277	FAD linked oxidase domain protein
AKN92_07245	COG0179	Fumarylacetoacetate (FAA) hydrolase
AKN92_07255	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AKN92_07345	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
AKN92_07380	COG2003	Belongs to the UPF0758 family
AKN92_07420	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AKN92_07425	COG3177	Filamentation induced by cAMP protein fic
AKN92_07455	COG3657	addiction module killer protein
AKN92_07460	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
AKN92_07470	COG2814	Major facilitator Superfamily
AKN92_07630	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
AKN92_07695	COG0305	Participates in initiation and elongation during chromosome replication
AKN92_07700	COG1192	Involved in chromosome partitioning
AKN92_07705	COG1752	Esterase of the alpha-beta hydrolase superfamily
AKN92_07720	COG0427	acetyl-CoA hydrolase
AKN92_07735	COG1538	Outer membrane efflux protein
AKN92_07740	COG2274	protein secretion by the type I secretion system
AKN92_07745	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AKN92_07780	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
AKN92_07785	COG0254	rRNA binding
AKN92_07790	COG0281	malic enzyme
AKN92_07825	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
AKN92_07830	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
AKN92_07850	COG0581	inorganic phosphate transmembrane transporter activity
AKN92_07855	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
AKN92_07860	COG0704	Plays a role in the regulation of phosphate uptake
AKN92_07865	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
AKN92_07870	COG1012	belongs to the aldehyde dehydrogenase family
AKN92_07875	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
AKN92_07895	COG0301	tRNA thio-modification
AKN92_07895	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AKN92_07900	COG1217	gtp-binding protein TYPA
AKN92_07910	COG0494	nUDIX hydrolase
AKN92_07930	COG3098	single-species biofilm formation
AKN92_07945	COG0204	Acyl-transferase
AKN92_07955	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
AKN92_07985	COG3150	esterase
AKN92_08005	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
AKN92_08015	COG3008	intermembrane lipid transfer
AKN92_08015	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
AKN92_08025	COG0560	Phosphoserine phosphatase
AKN92_08025	COG3830	Belongs to the UPF0237 family
AKN92_08030	COG2732	(Barnase) inhibitor
AKN92_08050	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AKN92_08060	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AKN92_08065	COG0006	proline dipeptidase activity
AKN92_08070	COG3079	Belongs to the UPF0149 family
AKN92_08085	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
AKN92_08090	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AKN92_08095	COG0842	Transport permease protein
AKN92_08095	COG1129	ABC transporter
AKN92_08100	COG0842	Transport permease protein
AKN92_08110	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
AKN92_08115	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
AKN92_08120	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
AKN92_08125	COG3178	'Phosphotransferase
AKN92_08130	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
AKN92_08135	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
AKN92_08145	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
AKN92_08165	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AKN92_08185	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
AKN92_08190	COG1509	lysine 2,3-aminomutase activity
AKN92_08195	COG0513	Belongs to the DEAD box helicase family
AKN92_08200	COG3530	Putative quorum-sensing-regulated virulence factor
AKN92_08225	COG0142	geranyltranstransferase activity
AKN92_08230	COG1722	exodeoxyribonuclease VII activity
AKN92_08240	COG0456	acetyltransferase
AKN92_08245	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
AKN92_08275	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
AKN92_08280	COG0546	phosphoglycolate phosphatase activity
AKN92_08300	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
AKN92_08305	COG0134	indole-3-glycerol-phosphate synthase activity
AKN92_08310	COG0237	dephospho-CoA kinase activity
AKN92_08320	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
AKN92_08325	COG0471	metal ion transport
AKN92_08325	COG0490	domain, Protein
AKN92_08330	COG1122	ATPase activity
AKN92_08335	COG4120	Belongs to the binding-protein-dependent transport system permease family
AKN92_08345	COG0525	valine-tRNA ligase activity
AKN92_08355	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
AKN92_08365	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
AKN92_08375	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
AKN92_08380	COG0632	four-way junction helicase activity
AKN92_08385	COG2255	four-way junction helicase activity
AKN92_08415	COG2885	chlorophyll binding
AKN92_08420	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
AKN92_08430	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
AKN92_08435	COG1970	mechanosensitive ion channel activity
AKN92_08440	COG0142	geranyltranstransferase activity
AKN92_08445	COG0261	This protein binds to 23S rRNA in the presence of protein L20
AKN92_08450	COG0211	Belongs to the bacterial ribosomal protein bL27 family
AKN92_08455	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
AKN92_08460	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
AKN92_08490	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
AKN92_08495	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
AKN92_08500	COG0814	amino acid
AKN92_08510	COG3258	Cytochrome c
AKN92_08515	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
AKN92_08520	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
AKN92_08520	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
AKN92_08525	COG1028	Short-chain dehydrogenase reductase Sdr
AKN92_08545	COG1923	regulation of RNA biosynthetic process
AKN92_08550	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
AKN92_08555	COG0330	HflC and HflK could
AKN92_08560	COG0330	HflC and HflK could
AKN92_08565	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
AKN92_08570	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
AKN92_08595	COG0545	Peptidyl-prolyl cis-trans isomerase
AKN92_08615	COG0793	Belongs to the peptidase S41A family
AKN92_08620	COG3321	synthase
AKN92_08620	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
AKN92_08620	COG4221	oxidoreductase activity
AKN92_08620	COG0604	alcohol dehydrogenase
AKN92_08625	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
AKN92_08635	COG0633	Ferredoxin
AKN92_08640	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
AKN92_08645	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
AKN92_08650	COG3313	Fe-S protein
AKN92_08660	COG2813	Specifically methylates the guanine in position
AKN92_08665	COG3118	belongs to the thioredoxin family
AKN92_08670	COG0534	Mate efflux family protein
AKN92_08675	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
AKN92_08680	COG0778	Nitroreductase
AKN92_08710	COG1067	ATP-dependent peptidase activity
AKN92_08720	COG0789	Transcriptional regulator
AKN92_08735	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
AKN92_08740	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
AKN92_08750	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
AKN92_08755	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
AKN92_08765	COG2226	methyltransferase
AKN92_08790	COG0688	phosphatidylethanolamine metabolic process
AKN92_08795	COG1162	GTPase activity
AKN92_08800	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
AKN92_08810	COG0802	atpase or kinase
AKN92_08815	COG0860	N-Acetylmuramoyl-L-alanine amidase
AKN92_08835	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
AKN92_08845	COG0545	Peptidyl-prolyl cis-trans isomerase
AKN92_08860	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
AKN92_08870	COG0436	Aminotransferase
AKN92_08880	COG1671	Belongs to the UPF0178 family
AKN92_08885	COG1362	aminopeptidase activity
AKN92_08905	COG0166	Belongs to the GPI family
AKN92_08915	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
AKN92_08920	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
AKN92_08930	COG0617	tRNA 3'-terminal CCA addition
AKN92_08940	COG3118	belongs to the thioredoxin family
AKN92_08945	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
AKN92_08950	COG1965	Belongs to the frataxin family
AKN92_08965	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
AKN92_08980	COG1011	Hydrolase
AKN92_09000	COG0815	Transfers the fatty acyl group on membrane lipoproteins
AKN92_09015	COG1702	phosphate starvation-inducible protein PhoH
AKN92_09020	COG1538	Outer membrane efflux protein
AKN92_09025	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
AKN92_09035	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
AKN92_09040	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
AKN92_09045	COG0659	secondary active sulfate transmembrane transporter activity
AKN92_09050	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
AKN92_09055	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
AKN92_09060	COG0723	plastoquinol--plastocyanin reductase activity
AKN92_09065	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
AKN92_09070	COG2857	Cytochrome c1
AKN92_09075	COG0625	glutathione transferase activity
AKN92_09080	COG2969	positive regulation of protein catabolic process
AKN92_09125	COG2211	Major facilitator Superfamily
AKN92_09130	COG3030	protein affecting phage T7 exclusion by the F plasmid
AKN92_09135	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
AKN92_09140	COG0459	protein refolding
AKN92_09145	COG1960	acyl-CoA dehydrogenase activity
AKN92_09150	COG1024	Enoyl-CoA hydratase
AKN92_09165	COG0583	DNA-binding transcription factor activity
AKN92_09175	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AKN92_09185	COG0183	Belongs to the thiolase family
AKN92_09190	COG1024	Enoyl-CoA hydratase
AKN92_09200	COG0786	glutamate:sodium symporter activity
AKN92_09205	COG0442	prolyl-tRNA aminoacylation
AKN92_09220	COG2900	Belongs to the SlyX family
AKN92_09225	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AKN92_09240	COG0668	transmembrane transport
AKN92_09245	COG4942	peptidase
AKN92_09250	COG1570	exodeoxyribonuclease VII activity
AKN92_09255	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
AKN92_09260	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AKN92_09265	COG3162	membrane
AKN92_09275	COG1294	oxidase, subunit
AKN92_09285	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
AKN92_09295	COG1522	sequence-specific DNA binding
AKN92_09305	COG0435	Glutathione S-transferase
AKN92_09310	COG1522	sequence-specific DNA binding
AKN92_09320	COG0435	Glutathione S-transferase
AKN92_09325	COG1522	sequence-specific DNA binding
AKN92_09335	COG0435	Glutathione S-transferase
AKN92_09370	COG3284	Transcriptional regulator
AKN92_09375	COG1132	(ABC) transporter
AKN92_09390	COG1286	toxin biosynthetic process
AKN92_09405	COG2925	Exonuclease
AKN92_09420	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AKN92_09425	COG0544	peptidyl-prolyl cis-trans isomerase activity
AKN92_09435	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
AKN92_09440	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
AKN92_09450	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
AKN92_09455	COG3089	Belongs to the UPF0270 family
AKN92_09460	COG0431	NADPH-dependent FMN reductase
AKN92_09465	COG2056	Na+-H+ antiporter family
AKN92_09470	COG2837	iron assimilation
AKN92_09475	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
AKN92_09485	COG2914	Belongs to the UPF0125 (RnfH) family
AKN92_09490	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
AKN92_09500	COG2326	polyphosphate kinase activity
AKN92_09505	COG3081	Nucleoid-associated protein
AKN92_09520	COG3171	Protein conserved in bacteria
AKN92_09530	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AKN92_09550	COG2610	gluconate transmembrane transporter activity
AKN92_09560	COG2084	Dehydrogenase
AKN92_09565	COG3622	Belongs to the hyi family
AKN92_09580	COG4695	Portal protein
AKN92_09790	COG0582	viral genome integration into host DNA
AKN92_09810	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
AKN92_09815	COG0352	thiamine-phosphate diphosphorylase activity
AKN92_09820	COG0351	phosphomethylpyrimidine kinase
AKN92_09820	COG0352	thiamine-phosphate diphosphorylase activity
AKN92_09835	COG0495	leucyl-tRNA aminoacylation
AKN92_09845	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AKN92_09845	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
AKN92_09855	COG1196	nuclear chromosome segregation
AKN92_09860	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
AKN92_09865	COG1546	Belongs to the CinA family
AKN92_09875	COG2137	regulation of response to DNA damage stimulus
AKN92_09890	COG0513	Belongs to the DEAD box helicase family
AKN92_09895	COG1946	Acyl-CoA thioesterase
AKN92_09930	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
AKN92_09935	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
AKN92_09940	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
AKN92_09945	COG0772	Belongs to the SEDS family
AKN92_09955	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
AKN92_09960	COG1181	Belongs to the D-alanine--D-alanine ligase family
AKN92_09975	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
AKN92_09980	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
AKN92_09990	COG0653	protein targeting
AKN92_09995	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
AKN92_10000	COG0494	nUDIX hydrolase
AKN92_10005	COG2096	Adenosyltransferase
AKN92_10015	COG1666	GTP binding
AKN92_10025	COG0557	exoribonuclease II activity
AKN92_10030	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AKN92_10035	COG0360	Binds together with S18 to 16S ribosomal RNA
AKN92_10050	COG0359	binds to the 23S rRNA
AKN92_10055	COG0305	Participates in initiation and elongation during chromosome replication
AKN92_10075	COG0138	bifunctional purine biosynthesis protein purh
AKN92_10105	COG2135	peptidase activity
AKN92_10115	COG1660	Displays ATPase and GTPase activities
AKN92_10130	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
AKN92_10155	COG3201	nicotinamide mononucleotide transporter
AKN92_10165	COG1846	Transcriptional regulator
AKN92_10175	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
AKN92_10190	COG1805	sodium ion transport
AKN92_10215	COG1477	protein flavinylation
AKN92_10225	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AKN92_10235	COG4591	ABC-type transport system involved in lipoprotein release permease component
AKN92_10250	COG0436	Aminotransferase
AKN92_10255	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AKN92_10265	COG4536	flavin adenine dinucleotide binding
AKN92_10275	COG1399	metal-binding, possibly nucleic acid-binding protein
AKN92_10280	COG0333	Belongs to the bacterial ribosomal protein bL32 family
AKN92_10285	COG0416	fatty acid biosynthetic process
AKN92_10300	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
AKN92_10305	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
AKN92_10310	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
AKN92_10315	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
AKN92_10320	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
AKN92_10335	COG0084	hydrolase, TatD family'
AKN92_10340	COG1643	Atp-dependent helicase
AKN92_10345	COG0826	peptidase U32
AKN92_10355	COG1214	PFAM Peptidase M22, glycoprotease
AKN92_10360	COG0742	ribosomal rna small subunit methyltransferase
AKN92_10380	COG0564	pseudouridine synthase activity
AKN92_10395	COG3720	iron ion transport
AKN92_10405	COG0848	biopolymer transport protein
AKN92_10410	COG4558	Periplasmic binding protein
AKN92_10415	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AKN92_10420	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
AKN92_10440	COG0165	Argininosuccinate lyase
AKN92_10455	COG0530	calcium, potassium:sodium antiporter activity
AKN92_10460	COG0471	metal ion transport
AKN92_10465	COG0513	Belongs to the DEAD box helicase family
AKN92_10480	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
AKN92_10495	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
AKN92_10560	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
AKN92_10565	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
AKN92_10585	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
AKN92_10620	COG1968	undecaprenyl-diphosphatase activity
AKN92_10655	COG0586	Pfam SNARE associated Golgi protein
AKN92_10660	COG2094	Belongs to the DNA glycosylase MPG family
AKN92_10665	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
AKN92_10670	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
AKN92_10685	COG0768	penicillin binding
AKN92_10700	COG0542	response to heat
AKN92_10705	COG0586	Pfam SNARE associated Golgi protein
AKN92_10710	COG2094	Belongs to the DNA glycosylase MPG family
AKN92_10715	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
AKN92_10720	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
AKN92_10735	COG0768	penicillin binding
AKN92_10740	COG0772	Belongs to the SEDS family
AKN92_10745	COG2951	lytic endotransglycosylase activity
AKN92_10755	COG1686	Belongs to the peptidase S11 family
AKN92_10765	COG0321	lipoyl(octanoyl) transferase activity
AKN92_10770	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
AKN92_10780	COG2264	protein methyltransferase activity
AKN92_10805	COG0730	response to heat
AKN92_10810	COG0514	ATP-dependent DNA helicase (RecQ)
AKN92_10815	COG2076	Multidrug Resistance protein
AKN92_10825	COG5592	hemerythrin HHE cation binding domain
AKN92_10830	COG0602	queuosine metabolic process
AKN92_10835	COG0720	synthase
AKN92_10855	COG2823	Periplasmic or secreted lipoprotein
AKN92_10860	COG0363	glucosamine-6-phosphate deaminase activity
AKN92_10875	COG2967	ApaG domain
AKN92_10880	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
AKN92_10885	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AKN92_10895	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
AKN92_10905	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
AKN92_10915	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
AKN92_10920	COG0795	lipopolysaccharide-transporting ATPase activity
AKN92_10925	COG0795	lipopolysaccharide-transporting ATPase activity
AKN92_10930	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
AKN92_10935	COG2027	D-alanyl-D-alanine carboxypeptidase
AKN92_10945	COG2847	Copper chaperone PCu(A)C
AKN92_10950	COG1278	Cold shock
AKN92_10955	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
AKN92_10960	COG0542	response to heat
AKN92_10975	COG2030	dehydratase
AKN92_10980	COG0318	PFAM AMP-dependent synthetase and ligase
AKN92_10985	COG0589	response to stress
AKN92_10990	COG1252	NADH dehydrogenase
AKN92_11000	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
AKN92_11010	COG0148	phosphopyruvate hydratase activity
AKN92_11015	COG2877	3-deoxy-8-phosphooctulonate synthase activity
AKN92_11020	COG0504	CTP synthase activity
AKN92_11045	COG1199	ATP-dependent helicase activity
AKN92_11055	COG0167	dihydroorotate dehydrogenase activity
AKN92_11060	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AKN92_11070	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AKN92_11080	COG3243	poly(R)-hydroxyalkanoic acid synthase
AKN92_11090	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
AKN92_11105	COG0800	Aldolase
AKN92_11120	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
AKN92_11125	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
AKN92_11130	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
AKN92_11145	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
AKN92_11150	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
AKN92_11165	COG2989	Protein conserved in bacteria
AKN92_11170	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
AKN92_11180	COG0291	Belongs to the bacterial ribosomal protein bL35 family
AKN92_11185	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
AKN92_11190	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
AKN92_11195	COG0072	phenylalanine-tRNA ligase activity
AKN92_11200	COG0776	regulation of translation
AKN92_11235	COG0693	protein deglycase activity
AKN92_11245	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
AKN92_11270	COG1262	PFAM Formylglycine-generating sulfatase enzyme
AKN92_11270	COG0515	serine threonine protein kinase
AKN92_11320	COG0582	viral genome integration into host DNA
AKN92_11380	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
AKN92_11500	COG0740	serine-type endopeptidase activity