locus-tag	class	description
AKN91_00010	COG3284	Transcriptional regulator
AKN91_00015	COG1132	(ABC) transporter
AKN91_00055	COG0644	oxidoreductase
AKN91_00060	COG2860	membrane
AKN91_00065	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
AKN91_00080	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
AKN91_00095	COG2226	methyltransferase
AKN91_00105	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
AKN91_00125	COG2153	protein acetylation
AKN91_00130	COG2850	peptidyl-arginine hydroxylation
AKN91_00140	COG0697	spore germination
AKN91_00145	COG2915	High frequency lysogenization protein hflD homolog
AKN91_00150	COG0482	sulfurtransferase activity
AKN91_00155	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
AKN91_00160	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
AKN91_00165	COG0753	catalase activity
AKN91_00180	COG4172	Belongs to the ABC transporter superfamily
AKN91_00185	COG4239	(ABC) transporter, permease
AKN91_00190	COG4174	ABC transporter (Permease)
AKN91_00195	COG4166	transmembrane transport
AKN91_00205	COG0741	lytic transglycosylase activity
AKN91_00205	COG1388	LysM domain
AKN91_00215	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
AKN91_00220	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
AKN91_00235	COG0488	(ABC) transporter
AKN91_00240	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
AKN91_00245	COG0405	Gamma-glutamyltransferase
AKN91_00250	COG0589	response to stress
AKN91_00255	COG1024	Enoyl-CoA hydratase
AKN91_00255	COG1250	3-hydroxyacyl-CoA dehydrogenase
AKN91_00260	COG0183	Belongs to the thiolase family
AKN91_00300	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
AKN91_00310	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
AKN91_00315	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
AKN91_00315	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
AKN91_00325	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
AKN91_00335	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
AKN91_00345	COG4206	TonB-dependent receptor
AKN91_00360	COG0018	arginyl-trna synthetase
AKN91_00365	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
AKN91_00380	COG0739	heme binding
AKN91_00380	COG0741	lytic transglycosylase activity
AKN91_00380	COG1196	nuclear chromosome segregation
AKN91_00395	COG2840	Smr protein MutS2
AKN91_00400	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
AKN91_00420	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
AKN91_00425	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
AKN91_00425	COG0316	Belongs to the HesB IscA family
AKN91_00430	COG0776	regulation of translation
AKN91_00450	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AKN91_00470	COG0492	ferredoxin-NADP+ reductase activity
AKN91_00475	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
AKN91_00480	COG4521	taurine ABC transporter
AKN91_00485	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
AKN91_00490	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AKN91_00500	COG0741	lytic transglycosylase activity
AKN91_00520	COG2217	Heavy metal translocating P-type atpase
AKN91_00535	COG2010	Cytochrome c
AKN91_00550	COG3278	Belongs to the heme-copper respiratory oxidase family
AKN91_00560	COG2084	Dehydrogenase
AKN91_00580	COG2009	succinate dehydrogenase
AKN91_00595	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
AKN91_00615	COG0045	succinate-CoA ligase (ADP-forming) activity
AKN91_00640	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
AKN91_00645	COG0789	Transcriptional regulator
AKN91_00670	COG1250	3-hydroxyacyl-CoA dehydrogenase
AKN91_00670	COG1024	Enoyl-CoA hydratase
AKN91_00675	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
AKN91_00680	COG1960	acyl-CoA dehydrogenase activity
AKN91_00685	COG0318	PFAM AMP-dependent synthetase and ligase
AKN91_00725	COG0583	DNA-binding transcription factor activity
AKN91_00755	COG0778	Nitroreductase
AKN91_00760	COG1492	cobalamin metabolic process
AKN91_00770	COG1120	ATPase activity
AKN91_00775	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AKN91_00780	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
AKN91_00805	COG0456	acetyltransferase
AKN91_00810	COG0492	ferredoxin-NADP+ reductase activity
AKN91_00815	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
AKN91_00835	COG1272	protein, Hemolysin III
AKN91_00845	COG2356	endonuclease I
AKN91_00850	COG2814	Major facilitator Superfamily
AKN91_00855	COG2855	membrane
AKN91_00860	COG4783	chaperone-mediated protein folding
AKN91_00865	COG0425	Belongs to the sulfur carrier protein TusA family
AKN91_00870	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
AKN91_00880	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AKN91_00890	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
AKN91_00895	COG0513	Belongs to the DEAD box helicase family
AKN91_00900	COG0400	carboxylic ester hydrolase activity
AKN91_00915	COG2885	chlorophyll binding
AKN91_00920	COG2366	antibiotic biosynthetic process
AKN91_00925	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
AKN91_00930	COG2259	Doxx family
AKN91_00940	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
AKN91_00950	COG1862	Preprotein translocase
AKN91_00975	COG0730	response to heat
AKN91_00980	COG0114	fumarate hydratase activity
AKN91_00985	COG0284	orotidine-5'-phosphate decarboxylase activity
AKN91_00990	COG2814	Major facilitator Superfamily
AKN91_00995	COG0037	tRNA processing
AKN91_01005	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
AKN91_01015	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
AKN91_01045	COG2239	Acts as a magnesium transporter
AKN91_01050	COG3630	sodium ion export across plasma membrane
AKN91_01055	COG0511	ligase activity, forming carbon-carbon bonds
AKN91_01055	COG5016	pyruvate
AKN91_01065	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
AKN91_01075	COG2333	competence protein COMEC
AKN91_01075	COG0658	competence protein
AKN91_01080	COG1663	tetraacyldisaccharide 4'-kinase activity
AKN91_01085	COG2835	tetraacyldisaccharide 4'-kinase activity
AKN91_01090	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
AKN91_01095	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
AKN91_01100	COG0812	UDP-N-acetylmuramate dehydrogenase activity
AKN91_01125	COG0616	signal peptide processing
AKN91_01130	COG0604	alcohol dehydrogenase
AKN91_01145	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
AKN91_01160	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
AKN91_01165	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
AKN91_01175	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
AKN91_01180	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
AKN91_01190	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
AKN91_01195	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
AKN91_01205	COG2814	Major facilitator Superfamily
AKN91_01240	COG2166	iron-sulfur cluster assembly
AKN91_01245	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
AKN91_01250	COG2171	N-acyltransferase activity
AKN91_01255	COG1393	Belongs to the ArsC family
AKN91_01260	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
AKN91_01265	COG0024	Methionine aminopeptidase
AKN91_01270	COG0052	Belongs to the universal ribosomal protein uS2 family
AKN91_01275	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
AKN91_01280	COG0528	UMP kinase activity
AKN91_01285	COG0233	cytoplasmic translational termination
AKN91_01290	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
AKN91_01300	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
AKN91_01320	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AKN91_01325	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
AKN91_01330	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AKN91_01335	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AKN91_01345	COG2996	Protein conserved in bacteria
AKN91_01360	COG1136	(ABC) transporter
AKN91_01370	COG0556	nucleotide-excision repair
AKN91_01385	COG0604	alcohol dehydrogenase
AKN91_01390	COG2111	Na H antiporter
AKN91_01390	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
AKN91_01395	COG1006	Multisubunit Na H antiporter MnhC subunit
AKN91_01400	COG0651	ATP synthesis coupled electron transport
AKN91_01410	COG2212	antiporter activity
AKN91_01425	COG0513	Belongs to the DEAD box helicase family
AKN91_01450	COG0427	acetyl-CoA hydrolase
AKN91_01460	COG2885	chlorophyll binding
AKN91_01480	COG3842	ATPase activity
AKN91_01485	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
AKN91_01490	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
AKN91_01495	COG0469	pyruvate kinase activity
AKN91_01505	COG4208	sulfate ABC transporter
AKN91_01510	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
AKN91_01520	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
AKN91_01525	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
AKN91_01530	COG0730	response to heat
AKN91_01570	COG0582	viral genome integration into host DNA
AKN91_01590	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
AKN91_01600	COG0121	glutamine amidotransferase
AKN91_01610	COG0811	peptide transport
AKN91_01615	COG0811	peptide transport
AKN91_01620	COG0848	biopolymer transport protein
AKN91_01650	COG0271	Belongs to the BolA IbaG family
AKN91_01670	COG1132	(ABC) transporter
AKN91_01675	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
AKN91_01690	COG1605	Chorismate mutase
AKN91_01690	COG0077	Prephenate dehydratase
AKN91_01695	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
AKN91_01700	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
AKN91_01705	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
AKN91_01715	COG2824	Alkylphosphonate utilization operon protein PhnA
AKN91_01720	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
AKN91_01725	COG3115	cell septum assembly
AKN91_01730	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
AKN91_01735	COG2031	fatty acid transporter
AKN91_01740	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AKN91_01745	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
AKN91_01750	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AKN91_01755	COG0215	cysteine-tRNA ligase activity
AKN91_01760	COG2853	Lipoprotein
AKN91_01765	COG0788	formyltetrahydrofolate deformylase activity
AKN91_01770	COG0433	COG0433 Predicted ATPase
AKN91_01785	COG2373	Large extracellular alpha-helical protein
AKN91_01790	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AKN91_01850	COG1335	isochorismatase
AKN91_01875	COG0675	Transposase, IS605 OrfB family
AKN91_01885	COG2119	membrane
AKN91_01890	COG0069	glutamate synthase activity
AKN91_01895	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AKN91_01900	COG0023	Translation Initiation Factor
AKN91_01905	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AKN91_01905	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
AKN91_01910	COG2010	Cytochrome c
AKN91_01920	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
AKN91_01925	COG1024	Enoyl-CoA hydratase
AKN91_01940	COG0730	response to heat
AKN91_01965	COG1132	(ABC) transporter
AKN91_01980	COG1137	ATPase activity
AKN91_01985	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
AKN91_01995	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
AKN91_02005	COG1127	ABC transporter
AKN91_02010	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
AKN91_02030	COG5007	Belongs to the BolA IbaG family
AKN91_02035	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
AKN91_02040	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
AKN91_02045	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
AKN91_02050	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
AKN91_02060	COG4953	penicillin-binding protein 1C
AKN91_02075	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AKN91_02095	COG0560	Phosphoserine phosphatase
AKN91_02105	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
AKN91_02125	COG0037	tRNA processing
AKN91_02155	COG3409	Peptidoglycan-binding domain 1 protein
AKN91_02155	COG0860	N-Acetylmuramoyl-L-alanine amidase
AKN91_02165	COG1858	cytochrome C peroxidase
AKN91_02170	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
AKN91_02175	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
AKN91_02180	COG3781	membrane
AKN91_02185	COG0708	Exodeoxyribonuclease III
AKN91_02190	COG0729	surface antigen
AKN91_02195	COG2911	Protein conserved in bacteria
AKN91_02205	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
AKN91_02210	COG0585	pseudouridine synthase activity
AKN91_02215	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
AKN91_02235	COG2814	Major facilitator Superfamily
AKN91_02240	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AKN91_02250	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
AKN91_02260	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
AKN91_02280	COG0625	glutathione transferase activity
AKN91_02290	COG0628	permease
AKN91_02300	COG0420	3'-5' exonuclease activity
AKN91_02305	COG0419	ATPase involved in DNA repair
AKN91_02315	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
AKN91_02320	COG1397	ADP-ribosylglycohydrolase
AKN91_02340	COG2205	protein histidine kinase activity
AKN91_02340	COG0784	Response regulator, receiver
AKN91_02395	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
AKN91_02405	COG0535	radical SAM domain protein
AKN91_02415	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
AKN91_02420	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
AKN91_02425	COG0009	L-threonylcarbamoyladenylate synthase
AKN91_02430	COG0613	PHP domain protein
AKN91_02435	COG2917	probably involved in intracellular septation
AKN91_02440	COG2350	Protein conserved in bacteria
AKN91_02445	COG0745	RESPONSE REGULATOR receiver
AKN91_02455	COG0642	Histidine kinase
AKN91_02465	COG0133	tryptophan synthase activity
AKN91_02470	COG0791	NLP P60 protein
AKN91_02475	COG0791	NLP P60 protein
AKN91_02480	COG0842	Transport permease protein
AKN91_02485	COG1131	(ABC) transporter
AKN91_02505	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
AKN91_02510	COG1381	Involved in DNA repair and RecF pathway recombination
AKN91_02515	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
AKN91_02520	COG0571	ribonuclease III activity
AKN91_02530	COG0481	GTPase activity
AKN91_02535	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AKN91_02565	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AKN91_02565	COG4191	Histidine kinase
AKN91_02570	COG2204	response regulator
AKN91_02585	COG1024	Enoyl-CoA hydratase
AKN91_02610	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
AKN91_02620	COG0393	Putative heavy-metal-binding
AKN91_02625	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
AKN91_02630	COG1074	ATP-dependent DNA helicase activity
AKN91_02635	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
AKN91_02665	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
AKN91_02695	COG1025	Belongs to the peptidase M16 family
AKN91_02740	COG3133	Outer membrane lipoprotein
AKN91_02755	COG1360	Flagellar Motor Protein
AKN91_02760	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
AKN91_02780	COG1138	Cytochrome C-type biogenesis protein
AKN91_02805	COG4133	protoheme IX ABC transporter activity
AKN91_02810	COG0668	transmembrane transport
AKN91_02835	COG0066	3-isopropylmalate dehydratase activity
AKN91_02840	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
AKN91_02855	COG2252	PERMEase
AKN91_02860	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
AKN91_02865	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
AKN91_02875	COG1028	Short-chain dehydrogenase reductase Sdr
AKN91_02890	COG0346	lactoylglutathione lyase activity
AKN91_02895	COG0137	argininosuccinate synthase activity
AKN91_02900	COG0418	dihydroorotase activity
AKN91_02940	COG0402	S-adenosylhomocysteine deaminase activity
AKN91_02955	COG4181	ATPase activity
AKN91_02960	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
AKN91_02965	COG1335	isochorismatase
AKN91_02980	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
AKN91_02995	COG0308	aminopeptidase N
AKN91_03015	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
AKN91_03020	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
AKN91_03025	COG0425	Belongs to the sulfur carrier protein TusA family
AKN91_03045	COG1115	amino acid carrier protein
AKN91_03050	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
AKN91_03060	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
AKN91_03125	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
AKN91_03130	COG0328	RNA-DNA hybrid ribonuclease activity
AKN91_03140	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
AKN91_03145	COG4988	ABC transporter
AKN91_03150	COG2321	neutral zinc metallopeptidase
AKN91_03160	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
AKN91_03180	COG2223	nitrite transmembrane transporter activity
AKN91_03195	COG0189	ligase activity
AKN91_03205	COG0542	response to heat
AKN91_03255	COG0515	serine threonine protein kinase
AKN91_03255	COG1262	PFAM Formylglycine-generating sulfatase enzyme
AKN91_03280	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
AKN91_03290	COG0693	protein deglycase activity
AKN91_03325	COG0776	regulation of translation
AKN91_03330	COG0072	phenylalanine-tRNA ligase activity
AKN91_03335	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
AKN91_03340	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
AKN91_03345	COG0291	Belongs to the bacterial ribosomal protein bL35 family
AKN91_03355	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
AKN91_03360	COG2989	Protein conserved in bacteria
AKN91_03375	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
AKN91_03380	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
AKN91_03395	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
AKN91_03400	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
AKN91_03405	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
AKN91_03420	COG0800	Aldolase
AKN91_03435	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
AKN91_03445	COG3243	poly(R)-hydroxyalkanoic acid synthase
AKN91_03455	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AKN91_03465	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AKN91_03470	COG0167	dihydroorotate dehydrogenase activity
AKN91_03480	COG1199	ATP-dependent helicase activity
AKN91_03505	COG0504	CTP synthase activity
AKN91_03510	COG2877	3-deoxy-8-phosphooctulonate synthase activity
AKN91_03515	COG0148	phosphopyruvate hydratase activity
AKN91_03525	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
AKN91_03535	COG1252	NADH dehydrogenase
AKN91_03540	COG0589	response to stress
AKN91_03545	COG0318	PFAM AMP-dependent synthetase and ligase
AKN91_03550	COG2030	dehydratase
AKN91_03565	COG0542	response to heat
AKN91_03570	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
AKN91_03575	COG1278	Cold shock
AKN91_03580	COG2847	Copper chaperone PCu(A)C
AKN91_03590	COG2027	D-alanyl-D-alanine carboxypeptidase
AKN91_03595	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
AKN91_03600	COG0795	lipopolysaccharide-transporting ATPase activity
AKN91_03605	COG0795	lipopolysaccharide-transporting ATPase activity
AKN91_03610	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
AKN91_03620	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
AKN91_03630	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
AKN91_03640	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AKN91_03645	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
AKN91_03650	COG2967	ApaG domain
AKN91_03665	COG0363	glucosamine-6-phosphate deaminase activity
AKN91_03670	COG2823	Periplasmic or secreted lipoprotein
AKN91_03690	COG0720	synthase
AKN91_03695	COG0602	queuosine metabolic process
AKN91_03700	COG5592	hemerythrin HHE cation binding domain
AKN91_03710	COG2076	Multidrug Resistance protein
AKN91_03715	COG0514	ATP-dependent DNA helicase (RecQ)
AKN91_03720	COG0730	response to heat
AKN91_03745	COG2264	protein methyltransferase activity
AKN91_03755	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
AKN91_03760	COG0321	lipoyl(octanoyl) transferase activity
AKN91_03770	COG1686	Belongs to the peptidase S11 family
AKN91_03780	COG2951	lytic endotransglycosylase activity
AKN91_03785	COG0772	Belongs to the SEDS family
AKN91_03790	COG0768	penicillin binding
AKN91_03805	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
AKN91_03810	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
AKN91_03815	COG2094	Belongs to the DNA glycosylase MPG family
AKN91_03820	COG0586	Pfam SNARE associated Golgi protein
AKN91_03825	COG0542	response to heat
AKN91_03855	COG1968	undecaprenyl-diphosphatase activity
AKN91_03885	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
AKN91_03900	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
AKN91_03905	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
AKN91_03955	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AKN91_03960	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
AKN91_03980	COG3206	protein involved in exopolysaccharide biosynthesis
AKN91_03980	COG0489	protein tyrosine kinase activity
AKN91_04000	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AKN91_04050	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
AKN91_04065	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
AKN91_04085	COG0513	Belongs to the DEAD box helicase family
AKN91_04090	COG0471	metal ion transport
AKN91_04095	COG0530	calcium, potassium:sodium antiporter activity
AKN91_04110	COG0675	Transposase, IS605 OrfB family
AKN91_04120	COG0165	Argininosuccinate lyase
AKN91_04140	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
AKN91_04145	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AKN91_04150	COG4558	Periplasmic binding protein
AKN91_04155	COG0848	biopolymer transport protein
AKN91_04165	COG3720	iron ion transport
AKN91_04180	COG0564	pseudouridine synthase activity
AKN91_04200	COG0742	ribosomal rna small subunit methyltransferase
AKN91_04205	COG1214	PFAM Peptidase M22, glycoprotease
AKN91_04215	COG0826	peptidase U32
AKN91_04220	COG1643	Atp-dependent helicase
AKN91_04225	COG0084	hydrolase, TatD family'
AKN91_04240	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
AKN91_04245	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
AKN91_04250	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
AKN91_04255	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
AKN91_04260	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
AKN91_04275	COG0416	fatty acid biosynthetic process
AKN91_04280	COG0333	Belongs to the bacterial ribosomal protein bL32 family
AKN91_04285	COG1399	metal-binding, possibly nucleic acid-binding protein
AKN91_04295	COG4536	flavin adenine dinucleotide binding
AKN91_04305	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AKN91_04310	COG0436	Aminotransferase
AKN91_04325	COG4591	ABC-type transport system involved in lipoprotein release permease component
AKN91_04335	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AKN91_04345	COG1477	protein flavinylation
AKN91_04370	COG1805	sodium ion transport
AKN91_04385	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
AKN91_04395	COG1846	Transcriptional regulator
AKN91_04405	COG3201	nicotinamide mononucleotide transporter
AKN91_04430	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
AKN91_04445	COG1660	Displays ATPase and GTPase activities
AKN91_04455	COG2135	peptidase activity
AKN91_04485	COG0138	bifunctional purine biosynthesis protein purh
AKN91_04505	COG0305	Participates in initiation and elongation during chromosome replication
AKN91_04510	COG0359	binds to the 23S rRNA
AKN91_04525	COG0360	Binds together with S18 to 16S ribosomal RNA
AKN91_04530	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AKN91_04535	COG0557	exoribonuclease II activity
AKN91_04545	COG0322	excinuclease ABC activity
AKN91_04550	COG1666	GTP binding
AKN91_04560	COG2096	Adenosyltransferase
AKN91_04565	COG0494	nUDIX hydrolase
AKN91_04575	COG0653	protein targeting
AKN91_04585	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
AKN91_04590	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
AKN91_04605	COG1181	Belongs to the D-alanine--D-alanine ligase family
AKN91_04610	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
AKN91_04620	COG0772	Belongs to the SEDS family
AKN91_04625	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
AKN91_04630	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
AKN91_04635	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
AKN91_04670	COG1946	Acyl-CoA thioesterase
AKN91_04675	COG0513	Belongs to the DEAD box helicase family
AKN91_04690	COG2137	regulation of response to DNA damage stimulus
AKN91_04700	COG1546	Belongs to the CinA family
AKN91_04705	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
AKN91_04710	COG1196	nuclear chromosome segregation
AKN91_04720	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AKN91_04720	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
AKN91_04730	COG0495	leucyl-tRNA aminoacylation
AKN91_04745	COG0351	phosphomethylpyrimidine kinase
AKN91_04745	COG0352	thiamine-phosphate diphosphorylase activity
AKN91_04750	COG0352	thiamine-phosphate diphosphorylase activity
AKN91_04755	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
AKN91_04775	COG0582	viral genome integration into host DNA
AKN91_04780	COG3177	Filamentation induced by cAMP protein fic
AKN91_04820	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
AKN91_04875	COG3622	Belongs to the hyi family
AKN91_04880	COG2084	Dehydrogenase
AKN91_04890	COG2610	gluconate transmembrane transporter activity
AKN91_04910	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AKN91_04920	COG3171	Protein conserved in bacteria
AKN91_04935	COG3081	Nucleoid-associated protein
AKN91_04940	COG2326	polyphosphate kinase activity
AKN91_04950	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
AKN91_04955	COG2914	Belongs to the UPF0125 (RnfH) family
AKN91_04965	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
AKN91_04970	COG2837	iron assimilation
AKN91_04975	COG2056	Na+-H+ antiporter family
AKN91_04980	COG0431	NADPH-dependent FMN reductase
AKN91_04985	COG3089	Belongs to the UPF0270 family
AKN91_04990	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
AKN91_05000	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
AKN91_05005	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
AKN91_05015	COG0544	peptidyl-prolyl cis-trans isomerase activity
AKN91_05020	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AKN91_05035	COG2925	Exonuclease
AKN91_05050	COG1286	toxin biosynthetic process
AKN91_05065	COG1132	(ABC) transporter
AKN91_05070	COG3284	Transcriptional regulator
AKN91_05105	COG0435	Glutathione S-transferase
AKN91_05115	COG1522	sequence-specific DNA binding
AKN91_05120	COG0435	Glutathione S-transferase
AKN91_05130	COG1522	sequence-specific DNA binding
AKN91_05140	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
AKN91_05150	COG1294	oxidase, subunit
AKN91_05160	COG3162	membrane
AKN91_05165	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AKN91_05170	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
AKN91_05175	COG1570	exodeoxyribonuclease VII activity
AKN91_05180	COG4942	peptidase
AKN91_05185	COG0668	transmembrane transport
AKN91_05200	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AKN91_05205	COG2900	Belongs to the SlyX family
AKN91_05220	COG0442	prolyl-tRNA aminoacylation
AKN91_05225	COG0786	glutamate:sodium symporter activity
AKN91_05235	COG1024	Enoyl-CoA hydratase
AKN91_05240	COG0183	Belongs to the thiolase family
AKN91_05250	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AKN91_05260	COG0583	DNA-binding transcription factor activity
AKN91_05275	COG1024	Enoyl-CoA hydratase
AKN91_05280	COG1960	acyl-CoA dehydrogenase activity
AKN91_05285	COG0459	protein refolding
AKN91_05290	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
AKN91_05295	COG3030	protein affecting phage T7 exclusion by the F plasmid
AKN91_05300	COG2211	Major facilitator Superfamily
AKN91_05345	COG2969	positive regulation of protein catabolic process
AKN91_05350	COG0625	glutathione transferase activity
AKN91_05355	COG2857	Cytochrome c1
AKN91_05360	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
AKN91_05365	COG0723	plastoquinol--plastocyanin reductase activity
AKN91_05370	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
AKN91_05375	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
AKN91_05380	COG0659	secondary active sulfate transmembrane transporter activity
AKN91_05385	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
AKN91_05390	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
AKN91_05400	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
AKN91_05405	COG1538	Outer membrane efflux protein
AKN91_05410	COG1702	phosphate starvation-inducible protein PhoH
AKN91_05425	COG0815	Transfers the fatty acyl group on membrane lipoproteins
AKN91_05445	COG1011	Hydrolase
AKN91_05475	COG1965	Belongs to the frataxin family
AKN91_05480	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
AKN91_05485	COG3118	belongs to the thioredoxin family
AKN91_05495	COG0617	tRNA 3'-terminal CCA addition
AKN91_05505	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
AKN91_05510	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
AKN91_05520	COG0166	Belongs to the GPI family
AKN91_05540	COG1362	aminopeptidase activity
AKN91_05545	COG1671	Belongs to the UPF0178 family
AKN91_05555	COG0436	Aminotransferase
AKN91_05565	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
AKN91_05580	COG0545	Peptidyl-prolyl cis-trans isomerase
AKN91_05590	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
AKN91_05610	COG0860	N-Acetylmuramoyl-L-alanine amidase
AKN91_05615	COG0802	atpase or kinase
AKN91_05625	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
AKN91_05630	COG1162	GTPase activity
AKN91_05635	COG0688	phosphatidylethanolamine metabolic process
AKN91_05650	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
AKN91_05660	COG2226	methyltransferase
AKN91_05670	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
AKN91_05675	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
AKN91_05685	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
AKN91_05690	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
AKN91_05705	COG0789	Transcriptional regulator
AKN91_05715	COG1067	ATP-dependent peptidase activity
AKN91_05730	COG1136	(ABC) transporter
AKN91_05745	COG0778	Nitroreductase
AKN91_05750	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
AKN91_05755	COG0534	Mate efflux family protein
AKN91_05760	COG3118	belongs to the thioredoxin family
AKN91_05765	COG2813	Specifically methylates the guanine in position
AKN91_05775	COG3313	Fe-S protein
AKN91_05780	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
AKN91_05785	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
AKN91_05790	COG0633	Ferredoxin
AKN91_05800	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
AKN91_05805	COG4221	oxidoreductase activity
AKN91_05805	COG3321	synthase
AKN91_05805	COG0604	alcohol dehydrogenase
AKN91_05805	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
AKN91_05830	COG0545	Peptidyl-prolyl cis-trans isomerase
AKN91_05855	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
AKN91_05865	COG0330	HflC and HflK could
AKN91_05870	COG0330	HflC and HflK could
AKN91_05875	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
AKN91_05880	COG1923	regulation of RNA biosynthetic process
AKN91_05900	COG1028	Short-chain dehydrogenase reductase Sdr
AKN91_05905	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
AKN91_05905	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
AKN91_05910	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
AKN91_05915	COG3258	Cytochrome c
AKN91_05925	COG0814	amino acid
AKN91_05930	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
AKN91_05935	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
AKN91_05965	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
AKN91_05970	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
AKN91_05975	COG0211	Belongs to the bacterial ribosomal protein bL27 family
AKN91_05980	COG0261	This protein binds to 23S rRNA in the presence of protein L20
AKN91_05985	COG0142	geranyltranstransferase activity
AKN91_05990	COG1970	mechanosensitive ion channel activity
AKN91_06000	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
AKN91_06010	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
AKN91_06015	COG2885	chlorophyll binding
AKN91_06040	COG0824	Thioesterase
AKN91_06045	COG2255	four-way junction helicase activity
AKN91_06050	COG0632	four-way junction helicase activity
AKN91_06055	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
AKN91_06065	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
AKN91_06075	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
AKN91_06085	COG0525	valine-tRNA ligase activity
AKN91_06095	COG4120	Belongs to the binding-protein-dependent transport system permease family
AKN91_06100	COG1122	ATPase activity
AKN91_06105	COG0471	metal ion transport
AKN91_06105	COG0490	domain, Protein
AKN91_06110	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
AKN91_06120	COG0237	dephospho-CoA kinase activity
AKN91_06125	COG0134	indole-3-glycerol-phosphate synthase activity
AKN91_06130	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
AKN91_06150	COG0546	phosphoglycolate phosphatase activity
AKN91_06155	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
AKN91_06185	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
AKN91_06190	COG0456	acetyltransferase
AKN91_06200	COG1722	exodeoxyribonuclease VII activity
AKN91_06205	COG0142	geranyltranstransferase activity
AKN91_06230	COG3530	Putative quorum-sensing-regulated virulence factor
AKN91_06235	COG0513	Belongs to the DEAD box helicase family
AKN91_06240	COG1509	lysine 2,3-aminomutase activity
AKN91_06245	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
AKN91_06265	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AKN91_06285	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
AKN91_06295	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
AKN91_06300	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
AKN91_06305	COG3178	'Phosphotransferase
AKN91_06310	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
AKN91_06315	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
AKN91_06320	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
AKN91_06330	COG0842	Transport permease protein
AKN91_06335	COG1129	ABC transporter
AKN91_06335	COG0842	Transport permease protein
AKN91_06340	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AKN91_06345	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
AKN91_06360	COG3079	Belongs to the UPF0149 family
AKN91_06365	COG0006	proline dipeptidase activity
AKN91_06370	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AKN91_06380	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AKN91_06405	COG3830	Belongs to the UPF0237 family
AKN91_06405	COG0560	Phosphoserine phosphatase
AKN91_06415	COG3008	intermembrane lipid transfer
AKN91_06415	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
AKN91_06425	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
AKN91_06445	COG3150	esterase
AKN91_06475	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
AKN91_06485	COG0204	Acyl-transferase
AKN91_06500	COG3098	single-species biofilm formation
AKN91_06520	COG0494	nUDIX hydrolase
AKN91_06530	COG1217	gtp-binding protein TYPA
AKN91_06535	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AKN91_06535	COG0301	tRNA thio-modification
AKN91_06550	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
AKN91_06555	COG1012	belongs to the aldehyde dehydrogenase family
AKN91_06560	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
AKN91_06565	COG0704	Plays a role in the regulation of phosphate uptake
AKN91_06570	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
AKN91_06575	COG0573	inorganic phosphate transmembrane transporter activity
AKN91_06595	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
AKN91_06600	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
AKN91_06635	COG0281	malic enzyme
AKN91_06640	COG0254	rRNA binding
AKN91_06645	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
AKN91_06670	COG0427	acetyl-CoA hydrolase
AKN91_06685	COG1752	Esterase of the alpha-beta hydrolase superfamily
AKN91_06710	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AKN91_06720	COG0179	Fumarylacetoacetate (FAA) hydrolase
AKN91_06725	COG0277	FAD linked oxidase domain protein
AKN91_06730	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
AKN91_06740	COG2814	Major facilitator Superfamily
AKN91_06750	COG0753	catalase activity
AKN91_06760	COG0523	cobalamin synthesis protein
AKN91_06785	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
AKN91_06790	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AKN91_06800	COG0267	Belongs to the bacterial ribosomal protein bL33 family
AKN91_06805	COG0227	Belongs to the bacterial ribosomal protein bL28 family
AKN91_06810	COG2003	Belongs to the UPF0758 family
AKN91_06815	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
AKN91_06820	COG0756	dUTP diphosphatase activity
AKN91_06830	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
AKN91_06850	COG1160	GTP binding
AKN91_06875	COG0494	nUDIX hydrolase
AKN91_06885	COG1385	rRNA (uridine-N3-)-methyltransferase activity
AKN91_06895	COG1960	acyl-CoA dehydrogenase activity
AKN91_06915	COG1120	ATPase activity
AKN91_06920	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AKN91_06925	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AKN91_06930	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
AKN91_06945	COG2855	membrane
AKN91_06955	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
AKN91_06955	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
AKN91_06965	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
AKN91_06970	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AKN91_06975	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AKN91_07005	COG0730	response to heat
AKN91_07015	COG1414	Transcriptional regulator
AKN91_07025	COG4771	TonB-dependent receptor
AKN91_07035	COG1979	alcohol dehydrogenase
AKN91_07040	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
AKN91_07045	COG0583	DNA-binding transcription factor activity
AKN91_07060	COG0814	amino acid
AKN91_07065	COG1368	sulfuric ester hydrolase activity
AKN91_07080	COG4149	molybdate abc transporter
AKN91_07085	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
AKN91_07100	COG1177	transmembrane transport
AKN91_07105	COG1176	ABC-type spermidine putrescine transport system, permease component I
AKN91_07110	COG3842	ATPase activity
AKN91_07125	COG3909	cytochrome
AKN91_07130	COG1652	LysM domain
AKN91_07155	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
AKN91_07165	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
AKN91_07170	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
AKN91_07180	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AKN91_07185	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
AKN91_07190	COG4942	peptidase
AKN91_07195	COG0793	Belongs to the peptidase S41A family
AKN91_07220	COG0131	Imidazoleglycerol-phosphate dehydratase
AKN91_07235	COG1194	a g-specific adenine glycosylase
AKN91_07240	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
AKN91_07265	COG2353	YceI-like domain
AKN91_07270	COG3038	cytochrome b561
AKN91_07275	COG3241	Transfers electrons from cytochrome c551 to cytochrome oxidase
AKN91_07280	COG2193	ferroxidase activity
AKN91_07290	COG0126	phosphoglycerate kinase activity
AKN91_07295	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
AKN91_07305	COG1040	competence protein
AKN91_07310	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
AKN91_07315	COG0156	8-amino-7-oxononanoate synthase activity
AKN91_07320	COG2226	methyltransferase
AKN91_07320	COG1073	alpha beta
AKN91_07340	COG0303	'Molybdopterin
AKN91_07345	COG0521	Mo-molybdopterin cofactor biosynthetic process
AKN91_07395	COG2318	DinB family
AKN91_07455	COG1561	YicC-like family, N-terminal region
AKN91_07460	COG4628	conserved protein (DUF2132)
AKN91_07465	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
AKN91_07495	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
AKN91_07505	COG0826	peptidase U32
AKN91_07515	COG0318	PFAM AMP-dependent synthetase and ligase
AKN91_07535	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
AKN91_07540	COG0569	domain protein
AKN91_07545	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
AKN91_07550	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
AKN91_07555	COG0242	peptide deformylase activity
AKN91_07560	COG0758	DNA mediated transformation
AKN91_07565	COG0009	L-threonylcarbamoyladenylate synthase
AKN91_07575	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
AKN91_07580	COG2239	Acts as a magnesium transporter
AKN91_07585	COG1285	pathogenesis
AKN91_07590	COG0003	Pfam Anion-transporting ATPase
AKN91_07600	COG1966	Carbon starvation protein
AKN91_07625	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
AKN91_07630	COG0730	response to heat
AKN91_07635	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
AKN91_07640	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
AKN91_07660	COG3154	lipid carrier protein
AKN91_07665	COG0826	peptidase U32
AKN91_07670	COG0826	peptidase U32
AKN91_07675	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
AKN91_07690	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
AKN91_07705	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
AKN91_07710	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
AKN91_07720	COG0252	asparaginase activity
AKN91_07750	COG1132	(ABC) transporter
AKN91_07755	COG3620	sequence-specific DNA binding
AKN91_07755	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
AKN91_07755	COG0617	tRNA 3'-terminal CCA addition
AKN91_07765	COG0789	Transcriptional regulator
AKN91_07780	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
AKN91_07785	COG0129	dihydroxy-acid dehydratase activity
AKN91_07800	COG3135	benzoate transporter
AKN91_07805	COG1178	ABC-type Fe3 transport system permease component
AKN91_07810	COG0404	The glycine cleavage system catalyzes the degradation of glycine
AKN91_07820	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
AKN91_07820	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
AKN91_07830	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
AKN91_07845	COG0742	ribosomal rna small subunit methyltransferase
AKN91_07850	COG0612	Peptidase, M16
AKN91_07855	COG0612	Peptidase, M16
AKN91_07860	COG0552	protein localization to endoplasmic reticulum
AKN91_07865	COG2884	Cell division ATP-binding protein ftsE
AKN91_07870	COG2177	Part of the ABC transporter FtsEX involved in
AKN91_07880	COG2431	L-lysine efflux transmembrane transporter activity
AKN91_07895	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
AKN91_07900	COG0513	Belongs to the DEAD box helicase family
AKN91_07905	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
AKN91_07910	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
AKN91_07975	COG0700	Nucleoside recognition
AKN91_07980	COG3023	N-Acetylmuramoyl-L-alanine amidase
AKN91_07990	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
AKN91_07995	COG0355	proton-transporting ATP synthase activity, rotational mechanism
AKN91_08000	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
AKN91_08005	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
AKN91_08010	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
AKN91_08015	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
AKN91_08020	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
AKN91_08030	COG0356	it plays a direct role in the translocation of protons across the membrane
AKN91_08040	COG1475	DNA binding
AKN91_08045	COG1192	Involved in chromosome partitioning
AKN91_08060	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
AKN91_08070	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
AKN91_08075	COG0594	ribonuclease P activity
AKN91_08080	COG0230	Belongs to the bacterial ribosomal protein bL34 family
AKN91_08115	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
AKN91_08130	COG1758	RNA polymerase activity
AKN91_08135	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
AKN91_08155	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
AKN91_08165	COG2363	Small membrane protein
AKN91_08175	COG2022	thiamine diphosphate biosynthetic process
AKN91_08180	COG0220	tRNA (guanine-N7-)-methyltransferase activity
AKN91_08200	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
AKN91_08205	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
AKN91_08215	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
AKN91_08230	COG0248	Ppx GppA phosphatase
AKN91_08240	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
AKN91_08245	COG0592	DNA-directed DNA polymerase activity
AKN91_08250	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
AKN91_08280	COG0642	Histidine kinase
AKN91_08295	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AKN91_08305	COG0159	tryptophan synthase activity
AKN91_08310	COG0133	tryptophan synthase activity
AKN91_08320	COG1960	acyl-CoA dehydrogenase activity
AKN91_08330	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
AKN91_08335	COG0583	DNA-binding transcription factor activity
AKN91_08340	COG3384	dioxygenase
AKN91_08350	COG3038	cytochrome b561
AKN91_08355	COG1289	transmembrane transporter activity
AKN91_08360	COG1944	ATP diphosphatase activity
AKN91_08365	COG2207	Transcriptional regulator
AKN91_08375	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
AKN91_08385	COG0303	'Molybdopterin
AKN91_08390	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
AKN91_08400	COG0642	Histidine kinase
AKN91_08405	COG0745	RESPONSE REGULATOR receiver
AKN91_08410	COG1368	sulfuric ester hydrolase activity
AKN91_08440	COG0084	hydrolase, TatD family'
AKN91_08450	COG1451	nucleotide metabolic process
AKN91_08455	COG0071	Belongs to the small heat shock protein (HSP20) family
AKN91_08470	COG0175	sulfate reduction
AKN91_08475	COG0175	sulfate reduction
AKN91_08480	COG1648	precorrin-2 dehydrogenase activity
AKN91_08480	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
AKN91_08500	COG0306	phosphate transporter
AKN91_08505	COG1392	Phosphate transport regulator
AKN91_08515	COG0330	HflC and HflK could
AKN91_08550	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
AKN91_08560	COG0540	Belongs to the ATCase OTCase family
AKN91_08570	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
AKN91_08575	COG3204	pilus organization
AKN91_08585	COG0494	nUDIX hydrolase
AKN91_08590	COG1011	Hydrolase
AKN91_08620	COG1872	DUF167
AKN91_08625	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
AKN91_08630	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
AKN91_08630	COG2813	Specifically methylates the guanine in position
AKN91_08645	COG0635	Involved in the biosynthesis of porphyrin-containing compound
AKN91_08660	COG0583	DNA-binding transcription factor activity
AKN91_08665	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
AKN91_08680	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
AKN91_08700	COG0751	glycine-tRNA ligase activity
AKN91_08705	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
AKN91_08725	COG0347	Belongs to the P(II) protein family
AKN91_08740	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
AKN91_08745	COG3161	chorismate lyase activity
AKN91_08760	COG3258	Cytochrome c
AKN91_08765	COG2863	cytochrome
AKN91_08770	COG0606	chelatase, subunit chli
AKN91_08780	COG1028	Short-chain dehydrogenase reductase Sdr
AKN91_08785	COG1028	Short-chain dehydrogenase reductase Sdr
AKN91_08790	COG0019	diaminopimelate decarboxylase activity
AKN91_08795	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
AKN91_08815	COG4771	TonB-dependent receptor
AKN91_08825	COG4191	Histidine kinase
AKN91_08830	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
AKN91_08835	COG1519	Transferase
AKN91_08845	COG0501	Belongs to the peptidase M48B family
AKN91_08855	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AKN91_08860	COG3047	cAMP biosynthetic process
AKN91_08865	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
AKN91_08870	COG1490	D-aminoacyl-tRNA deacylase activity
AKN91_08875	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
AKN91_08880	COG0488	(ABC) transporter
AKN91_08890	COG2918	glutathione biosynthetic process
AKN91_08895	COG2183	response to ionizing radiation
AKN91_08910	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
AKN91_08915	COG0735	belongs to the Fur family
AKN91_08920	COG1121	(ABC) transporter
AKN91_08925	COG1108	ABC-type Mn2 Zn2 transport systems permease components
AKN91_08940	COG2011	ABC-type metal ion transport system permease component
AKN91_08945	COG1464	Belongs to the NlpA lipoprotein family
AKN91_08950	COG1765	OsmC-like protein
AKN91_08955	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
AKN91_08960	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
AKN91_08965	COG0537	adenosine 5'-monophosphoramidase activity
AKN91_08970	COG1981	membrane
AKN91_08975	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
AKN91_08980	COG0316	Belongs to the HesB IscA family
AKN91_08990	COG0739	heme binding
AKN91_08995	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
AKN91_09025	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
AKN91_09025	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
AKN91_09030	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
AKN91_09055	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
AKN91_09075	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
AKN91_09080	COG0081	regulation of translation
AKN91_09085	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
AKN91_09090	COG0222	ribosome binding
AKN91_09095	COG0085	RNA polymerase activity
AKN91_09105	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
AKN91_09110	COG0049	tRNA binding
AKN91_09115	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
AKN91_09120	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
AKN91_09125	COG0051	transcription antitermination factor activity, RNA binding
AKN91_09130	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
AKN91_09135	COG0088	Forms part of the polypeptide exit tunnel
AKN91_09145	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
AKN91_09150	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
AKN91_09155	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
AKN91_09160	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
AKN91_09170	COG0255	Belongs to the universal ribosomal protein uL29 family
AKN91_09175	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
AKN91_09180	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
AKN91_09185	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
AKN91_09195	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
AKN91_09200	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
AKN91_09205	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
AKN91_09210	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
AKN91_09215	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
AKN91_09220	COG1841	ribosomal large subunit assembly
AKN91_09225	COG0200	Binds to the 23S rRNA
AKN91_09240	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
AKN91_09245	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
AKN91_09250	COG0202	RNA polymerase activity
AKN91_09255	COG0203	ribosomal protein L17
AKN91_09265	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
AKN91_09285	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
AKN91_09300	COG2081	HI0933 family
AKN91_09310	COG3263	regulation of cellular component size
AKN91_09315	COG1196	nuclear chromosome segregation
AKN91_09315	COG3264	Mechanosensitive ion channel
AKN91_09320	COG0676	glucose-6-phosphate 1-epimerase activity
AKN91_09345	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
AKN91_09350	COG2176	DNA-directed DNA polymerase activity
AKN91_09360	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
AKN91_09385	COG0697	spore germination
AKN91_09390	COG1917	Cupin 2, conserved barrel domain protein
AKN91_09390	COG2207	Transcriptional regulator
AKN91_09395	COG0113	porphobilinogen synthase activity
AKN91_09400	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
AKN91_09415	COG1960	acyl-CoA dehydrogenase activity
AKN91_09425	COG0318	PFAM AMP-dependent synthetase and ligase
AKN91_09430	COG4191	Histidine kinase
AKN91_09435	COG4566	intracellular signal transduction
AKN91_09440	COG0617	tRNA 3'-terminal CCA addition
AKN91_09465	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
AKN91_09480	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
AKN91_09485	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
AKN91_09490	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
AKN91_09505	COG1346	cytolysis
AKN91_09510	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
AKN91_09510	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
AKN91_09515	COG4989	oxidoreductase activity
AKN91_09525	COG1301	dicarboxylic acid transport
AKN91_09540	COG4659	FMN binding
AKN91_09545	COG4658	electron transport chain
AKN91_09555	COG2878	Part of a membrane complex involved in electron transport
AKN91_09560	COG4657	Part of a membrane complex involved in electron transport
AKN91_09570	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AKN91_09590	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
AKN91_09595	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
AKN91_09605	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
AKN91_09610	COG0501	Belongs to the peptidase M48B family
AKN91_09620	COG1643	Atp-dependent helicase
AKN91_09645	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
AKN91_09650	COG1802	Transcriptional regulator
AKN91_09660	COG0372	Belongs to the citrate synthase family
AKN91_09665	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
AKN91_09675	COG2264	protein methyltransferase activity
AKN91_09685	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AKN91_09695	COG0318	PFAM AMP-dependent synthetase and ligase
AKN91_09700	COG0183	Belongs to the thiolase family
AKN91_09730	COG2873	o-acetylhomoserine
AKN91_09740	COG1690	Belongs to the RtcB family
AKN91_09745	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AKN91_09760	COG0288	reversible hydration of carbon dioxide
AKN91_09775	COG0022	dehydrogenase e1 component
AKN91_09780	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
AKN91_09800	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
AKN91_09810	COG1028	Short-chain dehydrogenase reductase Sdr
AKN91_09815	COG0671	phosphoesterase, PA-phosphatase related
AKN91_09820	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
AKN91_09825	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
AKN91_09830	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
AKN91_09840	COG1607	acyl-coa hydrolase
AKN91_09850	COG0861	Integral membrane protein TerC family
AKN91_09860	COG0488	(ABC) transporter
AKN91_09885	COG0181	hydroxymethylbilane synthase activity
AKN91_09910	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
AKN91_09915	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
AKN91_09920	COG3956	TIGRFAM MazG family protein
AKN91_09925	COG3122	Protein conserved in bacteria
AKN91_09935	COG3258	Cytochrome c
AKN91_09940	COG0268	Binds directly to 16S ribosomal RNA
AKN91_09945	COG0728	peptidoglycan biosynthetic process
AKN91_09950	COG0196	riboflavin kinase activity
AKN91_09955	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
AKN91_09965	COG1047	Peptidyl-prolyl cis-trans
AKN91_09970	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
AKN91_09985	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
AKN91_10000	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
AKN91_10025	COG4574	serine-type endopeptidase inhibitor activity
AKN91_10035	COG0322	excinuclease ABC activity
AKN91_10050	COG3100	YcgL domain-containing protein
AKN91_10055	COG1555	photosystem II stabilization
AKN91_10070	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
AKN91_10075	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
AKN91_10085	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AKN91_10115	COG0714	Associated with various cellular activities
AKN91_10120	COG0564	pseudouridine synthase activity
AKN91_10125	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
AKN91_10130	COG2894	cell division
AKN91_10135	COG0850	regulation of cytokinetic process
AKN91_10140	COG1560	Kdo2-lipid A biosynthetic process
AKN91_10150	COG2853	Lipoprotein
AKN91_10175	COG0489	protein tyrosine kinase activity
AKN91_10180	COG1278	Cold shock
AKN91_10185	COG0717	Belongs to the dCTP deaminase family
AKN91_10200	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
AKN91_10220	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
AKN91_10255	COG0438	transferase activity, transferring glycosyl groups
AKN91_10280	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
AKN91_10285	COG1091	dTDP-4-dehydrorhamnose reductase activity
AKN91_10300	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
AKN91_10305	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
AKN91_10310	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
AKN91_10310	COG2755	lipolytic protein G-D-S-L family
AKN91_10345	COG0438	transferase activity, transferring glycosyl groups
AKN91_10350	COG2192	nodulation
AKN91_10375	COG0438	transferase activity, transferring glycosyl groups
AKN91_10380	COG0859	PFAM glycosyl transferase family 9
AKN91_10385	COG0859	PFAM glycosyl transferase family 9
AKN91_10415	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
AKN91_10430	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
AKN91_10435	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
AKN91_10440	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
AKN91_10450	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
AKN91_10455	COG1077	Cell shape determining protein MreB Mrl
AKN91_10460	COG1792	Involved in formation and maintenance of cell shape
AKN91_10470	COG0424	maF-like protein
AKN91_10475	COG1530	ribonuclease E activity
AKN91_10485	COG0497	DNA recombination
AKN91_10490	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
AKN91_10495	COG0443	Heat shock 70 kDa protein
AKN91_10500	COG0484	heat shock protein binding
AKN91_10505	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
AKN91_10525	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
AKN91_10550	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
AKN91_10555	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AKN91_10560	COG0149	triose-phosphate isomerase activity
AKN91_10575	COG0779	Required for maturation of 30S ribosomal subunits
AKN91_10580	COG0195	Participates in both transcription termination and antitermination
AKN91_10585	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
AKN91_10590	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
AKN91_10595	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
AKN91_10600	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
AKN91_10605	COG1185	polyribonucleotide nucleotidyltransferase activity
AKN91_10615	COG0501	Belongs to the peptidase M48B family
AKN91_10620	COG3091	SprT-like family
AKN91_10635	COG0436	Aminotransferase
AKN91_10660	COG1104	cysteine desulfurase activity
AKN91_10670	COG0316	Belongs to the HesB IscA family
AKN91_10675	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
AKN91_10715	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
AKN91_10720	COG0124	histidyl-tRNA synthetase
AKN91_10735	COG1160	GTP binding
AKN91_10770	COG0446	pyridine nucleotide-disulphide oxidoreductase
AKN91_10770	COG1902	pentaerythritol trinitrate reductase activity
AKN91_10805	COG0424	maF-like protein
AKN91_10810	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
AKN91_10820	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
AKN91_10825	COG0336	Belongs to the RNA methyltransferase TrmD family
AKN91_10835	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
AKN91_10845	COG2823	Periplasmic or secreted lipoprotein
AKN91_10855	COG0792	nuclease activity
AKN91_10860	COG3107	peptidoglycan biosynthetic process
AKN91_10870	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
AKN91_10885	COG3223	Belongs to the PsiE family
AKN91_10895	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
AKN91_10900	COG0312	modulator of DNA gyrase
AKN91_10905	COG3028	Belongs to the UPF0307 family
AKN91_10910	COG0312	modulator of DNA gyrase
AKN91_10915	COG0028	Belongs to the TPP enzyme family
AKN91_10930	COG1183	phosphatidylcholine synthase activity