locus-tag	class	description
AKN90_00015	COG0189	ligase activity
AKN90_00030	COG2223	nitrite transmembrane transporter activity
AKN90_00050	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
AKN90_00060	COG2321	neutral zinc metallopeptidase
AKN90_00065	COG4988	ABC transporter
AKN90_00070	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
AKN90_00080	COG0328	RNA-DNA hybrid ribonuclease activity
AKN90_00085	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
AKN90_00150	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
AKN90_00160	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
AKN90_00165	COG1115	amino acid carrier protein
AKN90_00200	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
AKN90_00210	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
AKN90_00215	COG1115	amino acid carrier protein
AKN90_00235	COG0425	Belongs to the sulfur carrier protein TusA family
AKN90_00240	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
AKN90_00245	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
AKN90_00265	COG0308	aminopeptidase N
AKN90_00280	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
AKN90_00295	COG1335	isochorismatase
AKN90_00300	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
AKN90_00305	COG4181	ATPase activity
AKN90_00320	COG0402	S-adenosylhomocysteine deaminase activity
AKN90_00360	COG0418	dihydroorotase activity
AKN90_00365	COG0137	argininosuccinate synthase activity
AKN90_00370	COG0346	lactoylglutathione lyase activity
AKN90_00385	COG1028	Short-chain dehydrogenase reductase Sdr
AKN90_00395	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
AKN90_00400	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
AKN90_00405	COG2252	PERMEase
AKN90_00420	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
AKN90_00425	COG0066	3-isopropylmalate dehydratase activity
AKN90_00450	COG0668	transmembrane transport
AKN90_00455	COG4133	protoheme IX ABC transporter activity
AKN90_00480	COG1138	Cytochrome C-type biogenesis protein
AKN90_00500	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
AKN90_00505	COG1360	Flagellar Motor Protein
AKN90_00520	COG3133	Outer membrane lipoprotein
AKN90_00565	COG1025	Belongs to the peptidase M16 family
AKN90_00595	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
AKN90_00630	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
AKN90_00685	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
AKN90_00690	COG1074	ATP-dependent DNA helicase activity
AKN90_00695	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
AKN90_00700	COG0393	Putative heavy-metal-binding
AKN90_00710	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
AKN90_00735	COG1024	Enoyl-CoA hydratase
AKN90_00750	COG2204	response regulator
AKN90_00755	COG4191	Histidine kinase
AKN90_00755	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AKN90_00785	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AKN90_00790	COG0481	GTPase activity
AKN90_00800	COG0571	ribonuclease III activity
AKN90_00805	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
AKN90_00810	COG1381	Involved in DNA repair and RecF pathway recombination
AKN90_00815	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
AKN90_00835	COG1131	(ABC) transporter
AKN90_00840	COG0842	Transport permease protein
AKN90_00845	COG0791	NLP P60 protein
AKN90_00850	COG0791	NLP P60 protein
AKN90_00855	COG0133	tryptophan synthase activity
AKN90_00865	COG0642	Histidine kinase
AKN90_00875	COG0745	RESPONSE REGULATOR receiver
AKN90_00880	COG2350	Protein conserved in bacteria
AKN90_00885	COG2917	probably involved in intracellular septation
AKN90_00890	COG0613	PHP domain protein
AKN90_00895	COG0009	L-threonylcarbamoyladenylate synthase
AKN90_00900	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
AKN90_00905	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
AKN90_00915	COG0535	radical SAM domain protein
AKN90_00925	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
AKN90_00980	COG0784	Response regulator, receiver
AKN90_00980	COG2205	protein histidine kinase activity
AKN90_01000	COG1397	ADP-ribosylglycohydrolase
AKN90_01035	COG0419	ATPase involved in DNA repair
AKN90_01040	COG0420	3'-5' exonuclease activity
AKN90_01050	COG0628	permease
AKN90_01060	COG0625	glutathione transferase activity
AKN90_01080	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
AKN90_01090	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
AKN90_01100	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AKN90_01105	COG2814	Major facilitator Superfamily
AKN90_01125	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
AKN90_01130	COG0585	pseudouridine synthase activity
AKN90_01135	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
AKN90_01145	COG2911	Protein conserved in bacteria
AKN90_01150	COG0729	surface antigen
AKN90_01155	COG0708	Exodeoxyribonuclease III
AKN90_01160	COG3781	membrane
AKN90_01165	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
AKN90_01170	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
AKN90_01185	COG0338	D12 class N6 adenine-specific DNA methyltransferase
AKN90_01225	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
AKN90_01265	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
AKN90_01275	COG1074	ATP-dependent DNA helicase activity
AKN90_01280	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
AKN90_01285	COG0393	Putative heavy-metal-binding
AKN90_01295	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
AKN90_01320	COG1024	Enoyl-CoA hydratase
AKN90_01335	COG2204	response regulator
AKN90_01340	COG4191	Histidine kinase
AKN90_01340	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AKN90_01370	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
AKN90_01375	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
AKN90_01380	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
AKN90_01385	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
AKN90_01390	COG5007	Belongs to the BolA IbaG family
AKN90_01410	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
AKN90_01415	COG1127	ABC transporter
AKN90_01425	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
AKN90_01435	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
AKN90_01440	COG1137	ATPase activity
AKN90_01455	COG1132	(ABC) transporter
AKN90_01475	COG0730	response to heat
AKN90_01490	COG1024	Enoyl-CoA hydratase
AKN90_01495	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
AKN90_01505	COG2010	Cytochrome c
AKN90_01510	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AKN90_01510	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
AKN90_01515	COG0023	Translation Initiation Factor
AKN90_01520	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AKN90_01525	COG0069	glutamate synthase activity
AKN90_01530	COG2119	membrane
AKN90_01535	COG5394	Polyhydroxyalkanoate synthesis repressor PhaR
AKN90_01540	COG0675	Transposase, IS605 OrfB family
AKN90_01565	COG1335	isochorismatase
AKN90_01635	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AKN90_01640	COG2373	Large extracellular alpha-helical protein
AKN90_01655	COG0433	COG0433 Predicted ATPase
AKN90_01660	COG0788	formyltetrahydrofolate deformylase activity
AKN90_01665	COG2853	Lipoprotein
AKN90_01670	COG0215	cysteine-tRNA ligase activity
AKN90_01675	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AKN90_01680	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
AKN90_01685	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AKN90_01690	COG2031	fatty acid transporter
AKN90_01695	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
AKN90_01700	COG3115	cell septum assembly
AKN90_01705	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
AKN90_01710	COG2824	Alkylphosphonate utilization operon protein PhnA
AKN90_01720	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
AKN90_01725	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
AKN90_01730	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
AKN90_01735	COG0077	Prephenate dehydratase
AKN90_01735	COG1605	Chorismate mutase
AKN90_01750	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
AKN90_01755	COG1132	(ABC) transporter
AKN90_01775	COG0271	Belongs to the BolA IbaG family
AKN90_01805	COG0848	biopolymer transport protein
AKN90_01810	COG0811	peptide transport
AKN90_01815	COG0811	peptide transport
AKN90_01825	COG0121	glutamine amidotransferase
AKN90_01835	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
AKN90_01850	COG2826	transposase and inactivated derivatives, IS30 family
AKN90_01860	COG0842	Transport permease protein
AKN90_01865	COG0842	Transport permease protein
AKN90_01865	COG1129	ABC transporter
AKN90_01870	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AKN90_01875	COG1538	Outer membrane efflux protein
AKN90_01880	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
AKN90_01885	COG3243	poly(R)-hydroxyalkanoic acid synthase
AKN90_01890	COG1309	transcriptional regulator
AKN90_01920	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
AKN90_01930	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AKN90_01955	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AKN90_01960	COG1840	ABC-type Fe3 transport system, periplasmic component
AKN90_01965	COG1178	ABC-type Fe3 transport system permease component
AKN90_01970	COG3842	ATPase activity
AKN90_01985	COG0582	viral genome integration into host DNA
AKN90_02015	COG1002	Type II restriction enzyme, methylase subunits
AKN90_02020	COG1061	Type III restriction enzyme res subunit
AKN90_02025	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
AKN90_02085	COG0730	response to heat
AKN90_02090	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
AKN90_02095	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
AKN90_02105	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
AKN90_02110	COG4208	sulfate ABC transporter
AKN90_02120	COG0469	pyruvate kinase activity
AKN90_02125	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
AKN90_02130	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
AKN90_02135	COG3842	ATPase activity
AKN90_02145	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AKN90_02160	COG2885	chlorophyll binding
AKN90_02170	COG0427	acetyl-CoA hydrolase
AKN90_02195	COG0513	Belongs to the DEAD box helicase family
AKN90_02210	COG2212	antiporter activity
AKN90_02220	COG0651	ATP synthesis coupled electron transport
AKN90_02225	COG1006	Multisubunit Na H antiporter MnhC subunit
AKN90_02230	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
AKN90_02230	COG2111	Na H antiporter
AKN90_02235	COG0604	alcohol dehydrogenase
AKN90_02250	COG0556	nucleotide-excision repair
AKN90_02260	COG1136	(ABC) transporter
AKN90_02275	COG2996	Protein conserved in bacteria
AKN90_02285	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AKN90_02290	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AKN90_02295	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
AKN90_02300	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AKN90_02320	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
AKN90_02330	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
AKN90_02335	COG0233	cytoplasmic translational termination
AKN90_02340	COG0528	UMP kinase activity
AKN90_02345	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
AKN90_02350	COG0052	Belongs to the universal ribosomal protein uS2 family
AKN90_02355	COG0024	Methionine aminopeptidase
AKN90_02360	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
AKN90_02365	COG1393	Belongs to the ArsC family
AKN90_02370	COG2171	N-acyltransferase activity
AKN90_02375	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
AKN90_02380	COG2166	iron-sulfur cluster assembly
AKN90_02415	COG2814	Major facilitator Superfamily
AKN90_02425	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
AKN90_02430	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
AKN90_02440	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
AKN90_02445	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
AKN90_02455	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
AKN90_02460	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
AKN90_02475	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
AKN90_02490	COG0604	alcohol dehydrogenase
AKN90_02495	COG0616	signal peptide processing
AKN90_02520	COG0812	UDP-N-acetylmuramate dehydrogenase activity
AKN90_02525	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
AKN90_02530	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
AKN90_02535	COG2835	tetraacyldisaccharide 4'-kinase activity
AKN90_02540	COG1663	tetraacyldisaccharide 4'-kinase activity
AKN90_02545	COG0658	competence protein
AKN90_02545	COG2333	competence protein COMEC
AKN90_02555	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
AKN90_02565	COG0511	ligase activity, forming carbon-carbon bonds
AKN90_02565	COG5016	pyruvate
AKN90_02570	COG3630	sodium ion export across plasma membrane
AKN90_02575	COG2239	Acts as a magnesium transporter
AKN90_02600	COG0527	aspartate kinase activity
AKN90_02605	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
AKN90_02615	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
AKN90_02625	COG0037	tRNA processing
AKN90_02630	COG2814	Major facilitator Superfamily
AKN90_02635	COG0284	orotidine-5'-phosphate decarboxylase activity
AKN90_02640	COG0114	fumarate hydratase activity
AKN90_02645	COG0730	response to heat
AKN90_02670	COG1862	Preprotein translocase
AKN90_02680	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
AKN90_02690	COG2259	Doxx family
AKN90_02695	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
AKN90_02700	COG2366	antibiotic biosynthetic process
AKN90_02705	COG2885	chlorophyll binding
AKN90_02720	COG0400	carboxylic ester hydrolase activity
AKN90_02725	COG0513	Belongs to the DEAD box helicase family
AKN90_02730	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
AKN90_02740	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AKN90_02750	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
AKN90_02755	COG0425	Belongs to the sulfur carrier protein TusA family
AKN90_02760	COG4783	chaperone-mediated protein folding
AKN90_02770	COG2814	Major facilitator Superfamily
AKN90_02775	COG2356	endonuclease I
AKN90_02785	COG1272	protein, Hemolysin III
AKN90_02800	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
AKN90_02810	COG0456	acetyltransferase
AKN90_02835	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
AKN90_02840	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AKN90_02845	COG1120	ATPase activity
AKN90_02855	COG1492	cobalamin metabolic process
AKN90_02860	COG0778	Nitroreductase
AKN90_02880	COG0583	DNA-binding transcription factor activity
AKN90_02920	COG0318	PFAM AMP-dependent synthetase and ligase
AKN90_02925	COG1960	acyl-CoA dehydrogenase activity
AKN90_02930	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
AKN90_02935	COG1024	Enoyl-CoA hydratase
AKN90_02935	COG1250	3-hydroxyacyl-CoA dehydrogenase
AKN90_02960	COG0789	Transcriptional regulator
AKN90_02965	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
AKN90_02990	COG0045	succinate-CoA ligase (ADP-forming) activity
AKN90_03010	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
AKN90_03025	COG2009	succinate dehydrogenase
AKN90_03045	COG2084	Dehydrogenase
AKN90_03055	COG3278	Belongs to the heme-copper respiratory oxidase family
AKN90_03070	COG2010	Cytochrome c
AKN90_03085	COG2217	Heavy metal translocating P-type atpase
AKN90_03105	COG0741	lytic transglycosylase activity
AKN90_03110	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
AKN90_03115	COG0492	ferredoxin-NADP+ reductase activity
AKN90_03135	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AKN90_03155	COG0776	regulation of translation
AKN90_03160	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
AKN90_03160	COG0316	Belongs to the HesB IscA family
AKN90_03165	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
AKN90_03185	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
AKN90_03190	COG2840	Smr protein MutS2
AKN90_03205	COG1196	nuclear chromosome segregation
AKN90_03205	COG0741	lytic transglycosylase activity
AKN90_03205	COG0739	heme binding
AKN90_03220	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
AKN90_03225	COG0018	arginyl-trna synthetase
AKN90_03240	COG4206	TonB-dependent receptor
AKN90_03250	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
AKN90_03260	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
AKN90_03270	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
AKN90_03270	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
AKN90_03275	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
AKN90_03285	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
AKN90_03325	COG0183	Belongs to the thiolase family
AKN90_03330	COG1024	Enoyl-CoA hydratase
AKN90_03330	COG1250	3-hydroxyacyl-CoA dehydrogenase
AKN90_03335	COG0589	response to stress
AKN90_03340	COG0405	Gamma-glutamyltransferase
AKN90_03345	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
AKN90_03350	COG0488	(ABC) transporter
AKN90_03365	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
AKN90_03370	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
AKN90_03380	COG0741	lytic transglycosylase activity
AKN90_03380	COG1388	LysM domain
AKN90_03390	COG4166	transmembrane transport
AKN90_03395	COG4174	ABC transporter (Permease)
AKN90_03400	COG4239	(ABC) transporter, permease
AKN90_03405	COG4172	Belongs to the ABC transporter superfamily
AKN90_03420	COG0753	catalase activity
AKN90_03425	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
AKN90_03430	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
AKN90_03435	COG0482	sulfurtransferase activity
AKN90_03440	COG2915	High frequency lysogenization protein hflD homolog
AKN90_03445	COG0697	spore germination
AKN90_03455	COG2850	peptidyl-arginine hydroxylation
AKN90_03460	COG2153	protein acetylation
AKN90_03475	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
AKN90_03485	COG2226	methyltransferase
AKN90_03500	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
AKN90_03515	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
AKN90_03520	COG2860	membrane
AKN90_03560	COG0285	dihydrofolate synthase activity
AKN90_03565	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
AKN90_03570	COG0135	phosphoribosylanthranilate isomerase activity
AKN90_03590	COG0500	methyltransferase
AKN90_03620	COG1183	phosphatidylcholine synthase activity
AKN90_03635	COG0028	Belongs to the TPP enzyme family
AKN90_03640	COG0312	modulator of DNA gyrase
AKN90_03645	COG3028	Belongs to the UPF0307 family
AKN90_03650	COG0312	modulator of DNA gyrase
AKN90_03655	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
AKN90_03665	COG3223	Belongs to the PsiE family
AKN90_03680	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
AKN90_03690	COG3107	peptidoglycan biosynthetic process
AKN90_03695	COG0792	nuclease activity
AKN90_03705	COG2823	Periplasmic or secreted lipoprotein
AKN90_03715	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
AKN90_03725	COG0336	Belongs to the RNA methyltransferase TrmD family
AKN90_03730	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
AKN90_03740	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
AKN90_03745	COG0424	maF-like protein
AKN90_03780	COG1902	pentaerythritol trinitrate reductase activity
AKN90_03780	COG0446	pyridine nucleotide-disulphide oxidoreductase
AKN90_03815	COG1160	GTP binding
AKN90_03830	COG0124	histidyl-tRNA synthetase
AKN90_03835	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
AKN90_03875	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
AKN90_03880	COG0316	Belongs to the HesB IscA family
AKN90_03890	COG1104	cysteine desulfurase activity
AKN90_03915	COG0436	Aminotransferase
AKN90_03930	COG3091	SprT-like family
AKN90_03935	COG0501	Belongs to the peptidase M48B family
AKN90_03945	COG1185	polyribonucleotide nucleotidyltransferase activity
AKN90_03950	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
AKN90_03955	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
AKN90_03960	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
AKN90_03965	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
AKN90_03970	COG0195	Participates in both transcription termination and antitermination
AKN90_03975	COG0779	Required for maturation of 30S ribosomal subunits
AKN90_03990	COG0149	triose-phosphate isomerase activity
AKN90_03995	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AKN90_04000	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
AKN90_04025	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
AKN90_04045	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
AKN90_04050	COG0484	heat shock protein binding
AKN90_04055	COG0443	Heat shock 70 kDa protein
AKN90_04060	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
AKN90_04065	COG0497	DNA recombination
AKN90_04075	COG1530	ribonuclease E activity
AKN90_04080	COG0424	maF-like protein
AKN90_04090	COG1792	Involved in formation and maintenance of cell shape
AKN90_04095	COG1077	Cell shape determining protein MreB Mrl
AKN90_04100	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
AKN90_04110	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
AKN90_04115	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
AKN90_04125	COG1252	NADH dehydrogenase
AKN90_04140	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
AKN90_04155	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
AKN90_04180	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
AKN90_04210	COG0438	transferase activity, transferring glycosyl groups
AKN90_04215	COG0438	transferase activity, transferring glycosyl groups
AKN90_04240	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
AKN90_04260	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
AKN90_04295	COG2192	nodulation
AKN90_04320	COG0438	transferase activity, transferring glycosyl groups
AKN90_04325	COG0859	PFAM glycosyl transferase family 9
AKN90_04330	COG0859	PFAM glycosyl transferase family 9
AKN90_04340	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AKN90_04370	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
AKN90_04395	COG0717	Belongs to the dCTP deaminase family
AKN90_04400	COG1278	Cold shock
AKN90_04405	COG0489	protein tyrosine kinase activity
AKN90_04430	COG2853	Lipoprotein
AKN90_04440	COG1560	Kdo2-lipid A biosynthetic process
AKN90_04445	COG0850	regulation of cytokinetic process
AKN90_04450	COG2894	cell division
AKN90_04455	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
AKN90_04460	COG0564	pseudouridine synthase activity
AKN90_04465	COG0714	Associated with various cellular activities
AKN90_04495	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AKN90_04505	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
AKN90_04510	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
AKN90_04525	COG1555	photosystem II stabilization
AKN90_04530	COG3100	YcgL domain-containing protein
AKN90_04545	COG0322	excinuclease ABC activity
AKN90_04555	COG4574	serine-type endopeptidase inhibitor activity
AKN90_04580	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
AKN90_04595	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
AKN90_04610	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
AKN90_04615	COG1047	Peptidyl-prolyl cis-trans
AKN90_04625	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
AKN90_04630	COG0196	riboflavin kinase activity
AKN90_04635	COG0728	peptidoglycan biosynthetic process
AKN90_04640	COG0268	Binds directly to 16S ribosomal RNA
AKN90_04645	COG3258	Cytochrome c
AKN90_04655	COG3122	Protein conserved in bacteria
AKN90_04660	COG3956	TIGRFAM MazG family protein
AKN90_04665	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
AKN90_04670	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
AKN90_04695	COG0181	hydroxymethylbilane synthase activity
AKN90_04720	COG0488	(ABC) transporter
AKN90_04730	COG0861	Integral membrane protein TerC family
AKN90_04740	COG1607	acyl-coa hydrolase
AKN90_04750	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
AKN90_04755	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
AKN90_04760	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
AKN90_04765	COG0671	phosphoesterase, PA-phosphatase related
AKN90_04770	COG1028	Short-chain dehydrogenase reductase Sdr
AKN90_04780	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
AKN90_04800	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
AKN90_04805	COG0022	dehydrogenase e1 component
AKN90_04820	COG0288	reversible hydration of carbon dioxide
AKN90_04835	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AKN90_04840	COG1690	Belongs to the RtcB family
AKN90_04850	COG2873	o-acetylhomoserine
AKN90_04880	COG0183	Belongs to the thiolase family
AKN90_04885	COG0318	PFAM AMP-dependent synthetase and ligase
AKN90_04895	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AKN90_04905	COG2264	protein methyltransferase activity
AKN90_04915	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
AKN90_04920	COG0372	Belongs to the citrate synthase family
AKN90_04930	COG1802	Transcriptional regulator
AKN90_04935	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
AKN90_04960	COG1643	Atp-dependent helicase
AKN90_04970	COG0501	Belongs to the peptidase M48B family
AKN90_04975	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
AKN90_04985	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
AKN90_04990	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
AKN90_05010	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AKN90_05020	COG4657	Part of a membrane complex involved in electron transport
AKN90_05025	COG2878	Part of a membrane complex involved in electron transport
AKN90_05035	COG4658	electron transport chain
AKN90_05040	COG4659	FMN binding
AKN90_05055	COG1301	dicarboxylic acid transport
AKN90_05065	COG4989	oxidoreductase activity
AKN90_05070	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
AKN90_05070	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
AKN90_05075	COG1346	cytolysis
AKN90_05090	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
AKN90_05095	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
AKN90_05100	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
AKN90_05115	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
AKN90_05140	COG0617	tRNA 3'-terminal CCA addition
AKN90_05145	COG4566	intracellular signal transduction
AKN90_05150	COG4191	Histidine kinase
AKN90_05155	COG0318	PFAM AMP-dependent synthetase and ligase
AKN90_05165	COG1960	acyl-CoA dehydrogenase activity
AKN90_05180	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
AKN90_05185	COG0113	porphobilinogen synthase activity
AKN90_05190	COG2207	Transcriptional regulator
AKN90_05190	COG1917	Cupin 2, conserved barrel domain protein
AKN90_05195	COG0697	spore germination
AKN90_05220	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
AKN90_05230	COG2176	DNA-directed DNA polymerase activity
AKN90_05235	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
AKN90_05260	COG0676	glucose-6-phosphate 1-epimerase activity
AKN90_05265	COG1196	nuclear chromosome segregation
AKN90_05265	COG3264	Mechanosensitive ion channel
AKN90_05270	COG3263	regulation of cellular component size
AKN90_05280	COG2081	HI0933 family
AKN90_05295	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
AKN90_05315	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
AKN90_05325	COG0203	ribosomal protein L17
AKN90_05330	COG0202	RNA polymerase activity
AKN90_05335	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
AKN90_05340	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
AKN90_05355	COG0200	Binds to the 23S rRNA
AKN90_05360	COG1841	ribosomal large subunit assembly
AKN90_05365	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
AKN90_05370	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
AKN90_05375	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
AKN90_05380	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
AKN90_05385	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
AKN90_05395	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
AKN90_05400	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
AKN90_05405	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
AKN90_05410	COG0255	Belongs to the universal ribosomal protein uL29 family
AKN90_05420	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
AKN90_05425	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
AKN90_05430	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
AKN90_05435	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
AKN90_05445	COG0088	Forms part of the polypeptide exit tunnel
AKN90_05450	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
AKN90_05455	COG0051	transcription antitermination factor activity, RNA binding
AKN90_05460	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
AKN90_05465	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
AKN90_05470	COG0049	tRNA binding
AKN90_05475	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
AKN90_05485	COG0085	RNA polymerase activity
AKN90_05490	COG0222	ribosome binding
AKN90_05495	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
AKN90_05500	COG0081	regulation of translation
AKN90_05505	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
AKN90_05550	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
AKN90_05555	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
AKN90_05555	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
AKN90_05585	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
AKN90_05590	COG0739	heme binding
AKN90_05595	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
AKN90_05600	COG0316	Belongs to the HesB IscA family
AKN90_05605	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
AKN90_05610	COG1981	membrane
AKN90_05615	COG0537	adenosine 5'-monophosphoramidase activity
AKN90_05620	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
AKN90_05625	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
AKN90_05630	COG1765	OsmC-like protein
AKN90_05640	COG2011	ABC-type metal ion transport system permease component
AKN90_05655	COG1108	ABC-type Mn2 Zn2 transport systems permease components
AKN90_05660	COG1121	(ABC) transporter
AKN90_05665	COG0735	belongs to the Fur family
AKN90_05670	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
AKN90_05685	COG2183	response to ionizing radiation
AKN90_05690	COG2918	glutathione biosynthetic process
AKN90_05700	COG0488	(ABC) transporter
AKN90_05705	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
AKN90_05710	COG1490	D-aminoacyl-tRNA deacylase activity
AKN90_05715	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
AKN90_05720	COG3047	cAMP biosynthetic process
AKN90_05725	COG0318	PFAM AMP-dependent synthetase and ligase
AKN90_05730	COG1960	acyl-CoA dehydrogenase activity
AKN90_05735	COG1028	Short-chain dehydrogenase reductase Sdr
AKN90_05755	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AKN90_05765	COG0501	Belongs to the peptidase M48B family
AKN90_05775	COG1519	Transferase
AKN90_05780	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
AKN90_05785	COG4191	Histidine kinase
AKN90_05795	COG4771	TonB-dependent receptor
AKN90_05820	COG0019	diaminopimelate decarboxylase activity
AKN90_05825	COG1028	Short-chain dehydrogenase reductase Sdr
AKN90_05830	COG1028	Short-chain dehydrogenase reductase Sdr
AKN90_05840	COG0606	chelatase, subunit chli
AKN90_05845	COG2863	cytochrome
AKN90_05850	COG3258	Cytochrome c
AKN90_05865	COG3161	chorismate lyase activity
AKN90_05870	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
AKN90_05885	COG0347	Belongs to the P(II) protein family
AKN90_05905	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
AKN90_05910	COG0751	glycine-tRNA ligase activity
AKN90_05930	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
AKN90_05945	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
AKN90_05950	COG0583	DNA-binding transcription factor activity
AKN90_05965	COG0635	Involved in the biosynthesis of porphyrin-containing compound
AKN90_05980	COG2813	Specifically methylates the guanine in position
AKN90_05980	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
AKN90_05985	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
AKN90_05990	COG1872	DUF167
AKN90_06020	COG1011	Hydrolase
AKN90_06025	COG0494	nUDIX hydrolase
AKN90_06035	COG3204	pilus organization
AKN90_06040	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
AKN90_06050	COG0540	Belongs to the ATCase OTCase family
AKN90_06060	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
AKN90_06095	COG0330	HflC and HflK could
AKN90_06105	COG1392	Phosphate transport regulator
AKN90_06110	COG0306	phosphate transporter
AKN90_06130	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
AKN90_06130	COG1648	precorrin-2 dehydrogenase activity
AKN90_06135	COG0175	sulfate reduction
AKN90_06160	COG1451	nucleotide metabolic process
AKN90_06170	COG0084	hydrolase, TatD family'
AKN90_06220	COG1222	aaa ATPase
AKN90_06245	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
AKN90_06270	COG1368	sulfuric ester hydrolase activity
AKN90_06275	COG0745	RESPONSE REGULATOR receiver
AKN90_06280	COG0642	Histidine kinase
AKN90_06290	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
AKN90_06295	COG0303	'Molybdopterin
AKN90_06305	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
AKN90_06315	COG2207	Transcriptional regulator
AKN90_06320	COG1944	ATP diphosphatase activity
AKN90_06325	COG1289	transmembrane transporter activity
AKN90_06330	COG3038	cytochrome b561
AKN90_06340	COG3384	dioxygenase
AKN90_06345	COG0583	DNA-binding transcription factor activity
AKN90_06350	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
AKN90_06360	COG1960	acyl-CoA dehydrogenase activity
AKN90_06370	COG0133	tryptophan synthase activity
AKN90_06375	COG0159	tryptophan synthase activity
AKN90_06385	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AKN90_06400	COG0642	Histidine kinase
AKN90_06410	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
AKN90_06415	COG0592	DNA-directed DNA polymerase activity
AKN90_06420	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
AKN90_06430	COG0248	Ppx GppA phosphatase
AKN90_06445	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
AKN90_06460	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
AKN90_06465	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
AKN90_06485	COG0220	tRNA (guanine-N7-)-methyltransferase activity
AKN90_06490	COG2022	thiamine diphosphate biosynthetic process
AKN90_06500	COG2363	Small membrane protein
AKN90_06510	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
AKN90_06530	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
AKN90_06535	COG1758	RNA polymerase activity
AKN90_06550	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
AKN90_06590	COG0230	Belongs to the bacterial ribosomal protein bL34 family
AKN90_06595	COG0594	ribonuclease P activity
AKN90_06600	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
AKN90_06610	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
AKN90_06625	COG1192	Involved in chromosome partitioning
AKN90_06630	COG1475	DNA binding
AKN90_06640	COG0356	it plays a direct role in the translocation of protons across the membrane
AKN90_06650	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
AKN90_06655	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
AKN90_06660	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
AKN90_06665	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
AKN90_06670	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
AKN90_06675	COG0355	proton-transporting ATP synthase activity, rotational mechanism
AKN90_06680	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
AKN90_06690	COG3023	N-Acetylmuramoyl-L-alanine amidase
AKN90_06700	COG2431	L-lysine efflux transmembrane transporter activity
AKN90_06710	COG2177	Part of the ABC transporter FtsEX involved in
AKN90_06715	COG2884	Cell division ATP-binding protein ftsE
AKN90_06720	COG0552	protein localization to endoplasmic reticulum
AKN90_06725	COG0612	Peptidase, M16
AKN90_06730	COG0612	Peptidase, M16
AKN90_06735	COG0742	ribosomal rna small subunit methyltransferase
AKN90_06750	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
AKN90_06760	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
AKN90_06760	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
AKN90_06770	COG0404	The glycine cleavage system catalyzes the degradation of glycine
AKN90_06775	COG1178	ABC-type Fe3 transport system permease component
AKN90_06780	COG3135	benzoate transporter
AKN90_06785	COG1858	cytochrome C peroxidase
AKN90_06795	COG0129	dihydroxy-acid dehydratase activity
AKN90_06800	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
AKN90_06830	COG0789	Transcriptional regulator
AKN90_06840	COG3620	sequence-specific DNA binding
AKN90_06840	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
AKN90_06840	COG0617	tRNA 3'-terminal CCA addition
AKN90_06845	COG1132	(ABC) transporter
AKN90_06875	COG0252	asparaginase activity
AKN90_06880	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
AKN90_06885	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
AKN90_06900	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
AKN90_06915	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
AKN90_06920	COG0826	peptidase U32
AKN90_06925	COG0826	peptidase U32
AKN90_06930	COG3154	lipid carrier protein
AKN90_06965	COG1857	crispr-associated protein
AKN90_06975	COG1518	maintenance of DNA repeat elements
AKN90_06985	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
AKN90_06990	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
AKN90_06995	COG0730	response to heat
AKN90_07000	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
AKN90_07025	COG1966	Carbon starvation protein
AKN90_07035	COG0003	Pfam Anion-transporting ATPase
AKN90_07040	COG1285	pathogenesis
AKN90_07045	COG2239	Acts as a magnesium transporter
AKN90_07050	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
AKN90_07060	COG0009	L-threonylcarbamoyladenylate synthase
AKN90_07065	COG0758	DNA mediated transformation
AKN90_07070	COG0242	peptide deformylase activity
AKN90_07075	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
AKN90_07080	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
AKN90_07085	COG0569	domain protein
AKN90_07090	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
AKN90_07110	COG0318	PFAM AMP-dependent synthetase and ligase
AKN90_07120	COG0826	peptidase U32
AKN90_07130	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
AKN90_07155	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
AKN90_07160	COG4628	conserved protein (DUF2132)
AKN90_07165	COG1561	YicC-like family, N-terminal region
AKN90_07265	COG0521	Mo-molybdopterin cofactor biosynthetic process
AKN90_07270	COG0303	'Molybdopterin
AKN90_07290	COG2226	methyltransferase
AKN90_07290	COG1073	alpha beta
AKN90_07295	COG0156	8-amino-7-oxononanoate synthase activity
AKN90_07300	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
AKN90_07305	COG1040	competence protein
AKN90_07315	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
AKN90_07320	COG0126	phosphoglycerate kinase activity
AKN90_07330	COG2193	ferroxidase activity
AKN90_07335	COG3241	Transfers electrons from cytochrome c551 to cytochrome oxidase
AKN90_07340	COG3038	cytochrome b561
AKN90_07345	COG2353	YceI-like domain
AKN90_07360	COG1858	cytochrome C peroxidase
AKN90_07375	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
AKN90_07380	COG1194	a g-specific adenine glycosylase
AKN90_07395	COG0131	Imidazoleglycerol-phosphate dehydratase
AKN90_07410	COG0107	imidazoleglycerol-phosphate synthase activity
AKN90_07420	COG0793	Belongs to the peptidase S41A family
AKN90_07425	COG4942	peptidase
AKN90_07430	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
AKN90_07435	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AKN90_07445	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
AKN90_07450	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
AKN90_07460	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
AKN90_07485	COG1652	LysM domain
AKN90_07490	COG3909	cytochrome
AKN90_07505	COG3842	ATPase activity
AKN90_07510	COG1176	ABC-type spermidine putrescine transport system, permease component I
AKN90_07515	COG1177	transmembrane transport
AKN90_07530	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
AKN90_07535	COG4149	molybdate abc transporter
AKN90_07550	COG1368	sulfuric ester hydrolase activity
AKN90_07555	COG0814	amino acid
AKN90_07570	COG0583	DNA-binding transcription factor activity
AKN90_07575	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
AKN90_07580	COG1979	alcohol dehydrogenase
AKN90_07590	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
AKN90_07600	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
AKN90_07600	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
AKN90_07615	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
AKN90_07625	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AKN90_07635	COG4771	TonB-dependent receptor
AKN90_07645	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
AKN90_07650	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AKN90_07655	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AKN90_07660	COG1120	ATPase activity
AKN90_07680	COG1960	acyl-CoA dehydrogenase activity
AKN90_07690	COG1385	rRNA (uridine-N3-)-methyltransferase activity
AKN90_07700	COG0494	nUDIX hydrolase
AKN90_07725	COG1160	GTP binding
AKN90_07745	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
AKN90_07755	COG0756	dUTP diphosphatase activity
AKN90_07760	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
AKN90_07765	COG2003	Belongs to the UPF0758 family
AKN90_07770	COG0227	Belongs to the bacterial ribosomal protein bL28 family
AKN90_07775	COG0267	Belongs to the bacterial ribosomal protein bL33 family
AKN90_07785	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AKN90_07790	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
AKN90_07815	COG0523	cobalamin synthesis protein
AKN90_07825	COG0753	catalase activity
AKN90_07835	COG2814	Major facilitator Superfamily
AKN90_07845	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
AKN90_07850	COG0277	FAD linked oxidase domain protein
AKN90_07855	COG0179	Fumarylacetoacetate (FAA) hydrolase
AKN90_07865	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AKN90_07890	COG1752	Esterase of the alpha-beta hydrolase superfamily
AKN90_07905	COG0427	acetyl-CoA hydrolase
AKN90_07915	COG2274	protein secretion by the type I secretion system
AKN90_07920	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AKN90_07930	COG1538	Outer membrane efflux protein
AKN90_07935	COG2274	protein secretion by the type I secretion system
AKN90_07940	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AKN90_07955	COG0254	rRNA binding
AKN90_07960	COG0281	malic enzyme
AKN90_07995	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
AKN90_08000	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
AKN90_08020	COG0573	inorganic phosphate transmembrane transporter activity
AKN90_08025	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
AKN90_08030	COG0704	Plays a role in the regulation of phosphate uptake
AKN90_08035	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
AKN90_08040	COG1012	belongs to the aldehyde dehydrogenase family
AKN90_08045	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
AKN90_08060	COG0301	tRNA thio-modification
AKN90_08060	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AKN90_08065	COG1217	gtp-binding protein TYPA
AKN90_08075	COG0494	nUDIX hydrolase
AKN90_08095	COG3098	single-species biofilm formation
AKN90_08110	COG0204	Acyl-transferase
AKN90_08120	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
AKN90_08150	COG3150	esterase
AKN90_08170	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
AKN90_08180	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
AKN90_08180	COG3008	intermembrane lipid transfer
AKN90_08190	COG3830	Belongs to the UPF0237 family
AKN90_08190	COG0560	Phosphoserine phosphatase
AKN90_08215	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AKN90_08225	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AKN90_08230	COG0006	proline dipeptidase activity
AKN90_08235	COG3079	Belongs to the UPF0149 family
AKN90_08250	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
AKN90_08255	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AKN90_08260	COG0842	Transport permease protein
AKN90_08260	COG1129	ABC transporter
AKN90_08265	COG0842	Transport permease protein
AKN90_08275	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
AKN90_08280	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
AKN90_08285	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
AKN90_08290	COG3178	'Phosphotransferase
AKN90_08295	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
AKN90_08300	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
AKN90_08310	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
AKN90_08330	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AKN90_08350	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
AKN90_08355	COG1509	lysine 2,3-aminomutase activity
AKN90_08360	COG0513	Belongs to the DEAD box helicase family
AKN90_08365	COG3530	Putative quorum-sensing-regulated virulence factor
AKN90_08390	COG0142	geranyltranstransferase activity
AKN90_08395	COG1722	exodeoxyribonuclease VII activity
AKN90_08405	COG0456	acetyltransferase
AKN90_08410	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
AKN90_08440	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
AKN90_08445	COG0546	phosphoglycolate phosphatase activity
AKN90_08465	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
AKN90_08470	COG0134	indole-3-glycerol-phosphate synthase activity
AKN90_08475	COG0237	dephospho-CoA kinase activity
AKN90_08485	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
AKN90_08490	COG0471	metal ion transport
AKN90_08490	COG0490	domain, Protein
AKN90_08495	COG1122	ATPase activity
AKN90_08500	COG4120	Belongs to the binding-protein-dependent transport system permease family
AKN90_08510	COG0525	valine-tRNA ligase activity
AKN90_08520	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
AKN90_08530	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
AKN90_08540	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
AKN90_08545	COG0632	four-way junction helicase activity
AKN90_08550	COG2255	four-way junction helicase activity
AKN90_08555	COG0824	Thioesterase
AKN90_08580	COG2885	chlorophyll binding
AKN90_08585	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
AKN90_08595	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
AKN90_08600	COG1970	mechanosensitive ion channel activity
AKN90_08605	COG0142	geranyltranstransferase activity
AKN90_08610	COG0261	This protein binds to 23S rRNA in the presence of protein L20
AKN90_08615	COG0211	Belongs to the bacterial ribosomal protein bL27 family
AKN90_08620	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
AKN90_08625	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
AKN90_08655	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
AKN90_08660	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
AKN90_08665	COG0814	amino acid
AKN90_08675	COG3258	Cytochrome c
AKN90_08680	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
AKN90_08685	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
AKN90_08685	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
AKN90_08690	COG1028	Short-chain dehydrogenase reductase Sdr
AKN90_08710	COG1923	regulation of RNA biosynthetic process
AKN90_08715	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
AKN90_08720	COG0330	HflC and HflK could
AKN90_08725	COG0330	HflC and HflK could
AKN90_08730	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
AKN90_08735	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
AKN90_08760	COG0545	Peptidyl-prolyl cis-trans isomerase
AKN90_08780	COG0793	Belongs to the peptidase S41A family
AKN90_08785	COG4221	oxidoreductase activity
AKN90_08785	COG0604	alcohol dehydrogenase
AKN90_08785	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
AKN90_08785	COG3321	synthase
AKN90_08790	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
AKN90_08800	COG0633	Ferredoxin
AKN90_08805	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
AKN90_08810	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
AKN90_08815	COG3313	Fe-S protein
AKN90_08825	COG2813	Specifically methylates the guanine in position
AKN90_08830	COG3118	belongs to the thioredoxin family
AKN90_08835	COG0534	Mate efflux family protein
AKN90_08840	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
AKN90_08845	COG0778	Nitroreductase
AKN90_08860	COG1136	(ABC) transporter
AKN90_08875	COG1067	ATP-dependent peptidase activity
AKN90_08885	COG0789	Transcriptional regulator
AKN90_08900	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
AKN90_08905	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
AKN90_08915	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
AKN90_08920	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
AKN90_08930	COG2226	methyltransferase
AKN90_08940	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
AKN90_08960	COG0688	phosphatidylethanolamine metabolic process
AKN90_08965	COG1162	GTPase activity
AKN90_08970	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
AKN90_08980	COG0802	atpase or kinase
AKN90_08985	COG0860	N-Acetylmuramoyl-L-alanine amidase
AKN90_09005	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
AKN90_09015	COG0545	Peptidyl-prolyl cis-trans isomerase
AKN90_09030	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
AKN90_09040	COG0436	Aminotransferase
AKN90_09050	COG1671	Belongs to the UPF0178 family
AKN90_09055	COG1362	aminopeptidase activity
AKN90_09075	COG0166	Belongs to the GPI family
AKN90_09085	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
AKN90_09090	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
AKN90_09100	COG0617	tRNA 3'-terminal CCA addition
AKN90_09110	COG3118	belongs to the thioredoxin family
AKN90_09115	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
AKN90_09120	COG1965	Belongs to the frataxin family
AKN90_09135	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
AKN90_09150	COG1011	Hydrolase
AKN90_09170	COG0815	Transfers the fatty acyl group on membrane lipoproteins
AKN90_09185	COG1702	phosphate starvation-inducible protein PhoH
AKN90_09190	COG1538	Outer membrane efflux protein
AKN90_09195	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
AKN90_09205	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
AKN90_09210	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
AKN90_09215	COG0659	secondary active sulfate transmembrane transporter activity
AKN90_09220	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
AKN90_09225	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
AKN90_09230	COG0723	plastoquinol--plastocyanin reductase activity
AKN90_09235	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
AKN90_09240	COG2857	Cytochrome c1
AKN90_09245	COG0625	glutathione transferase activity
AKN90_09250	COG2969	positive regulation of protein catabolic process
AKN90_09295	COG2211	Major facilitator Superfamily
AKN90_09300	COG3030	protein affecting phage T7 exclusion by the F plasmid
AKN90_09305	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
AKN90_09310	COG0459	protein refolding
AKN90_09315	COG1960	acyl-CoA dehydrogenase activity
AKN90_09320	COG1024	Enoyl-CoA hydratase
AKN90_09335	COG0583	DNA-binding transcription factor activity
AKN90_09345	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AKN90_09355	COG0183	Belongs to the thiolase family
AKN90_09360	COG1024	Enoyl-CoA hydratase
AKN90_09370	COG0786	glutamate:sodium symporter activity
AKN90_09375	COG0442	prolyl-tRNA aminoacylation
AKN90_09390	COG2900	Belongs to the SlyX family
AKN90_09395	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AKN90_09410	COG0668	transmembrane transport
AKN90_09415	COG4942	peptidase
AKN90_09420	COG1570	exodeoxyribonuclease VII activity
AKN90_09425	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
AKN90_09430	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AKN90_09435	COG3162	membrane
AKN90_09445	COG1294	oxidase, subunit
AKN90_09455	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
AKN90_09465	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
AKN90_09475	COG1522	sequence-specific DNA binding
AKN90_09485	COG0435	Glutathione S-transferase
AKN90_09520	COG3284	Transcriptional regulator
AKN90_09525	COG1132	(ABC) transporter
AKN90_09540	COG1286	toxin biosynthetic process
AKN90_09555	COG2925	Exonuclease
AKN90_09570	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AKN90_09575	COG0544	peptidyl-prolyl cis-trans isomerase activity
AKN90_09585	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
AKN90_09590	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
AKN90_09600	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
AKN90_09605	COG3089	Belongs to the UPF0270 family
AKN90_09610	COG0431	NADPH-dependent FMN reductase
AKN90_09615	COG2056	Na+-H+ antiporter family
AKN90_09620	COG2837	iron assimilation
AKN90_09625	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
AKN90_09635	COG2914	Belongs to the UPF0125 (RnfH) family
AKN90_09640	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
AKN90_09650	COG2326	polyphosphate kinase activity
AKN90_09655	COG3081	Nucleoid-associated protein
AKN90_09670	COG3171	Protein conserved in bacteria
AKN90_09680	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AKN90_09700	COG2610	gluconate transmembrane transporter activity
AKN90_09710	COG2084	Dehydrogenase
AKN90_09715	COG3622	Belongs to the hyi family
AKN90_09745	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
AKN90_09750	COG0352	thiamine-phosphate diphosphorylase activity
AKN90_09755	COG0351	phosphomethylpyrimidine kinase
AKN90_09755	COG0352	thiamine-phosphate diphosphorylase activity
AKN90_09770	COG0495	leucyl-tRNA aminoacylation
AKN90_09780	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AKN90_09780	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
AKN90_09790	COG1196	nuclear chromosome segregation
AKN90_09795	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
AKN90_09800	COG1546	Belongs to the CinA family
AKN90_09810	COG2137	regulation of response to DNA damage stimulus
AKN90_09825	COG0513	Belongs to the DEAD box helicase family
AKN90_09830	COG1946	Acyl-CoA thioesterase
AKN90_09865	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
AKN90_09870	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
AKN90_09875	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
AKN90_09880	COG0772	Belongs to the SEDS family
AKN90_09890	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
AKN90_09895	COG1181	Belongs to the D-alanine--D-alanine ligase family
AKN90_09910	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
AKN90_09915	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
AKN90_09925	COG0653	protein targeting
AKN90_09930	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
AKN90_09935	COG0494	nUDIX hydrolase
AKN90_09940	COG2096	Adenosyltransferase
AKN90_09950	COG1666	GTP binding
AKN90_09960	COG0557	exoribonuclease II activity
AKN90_09965	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AKN90_09970	COG0360	Binds together with S18 to 16S ribosomal RNA
AKN90_09985	COG0359	binds to the 23S rRNA
AKN90_09990	COG0305	Participates in initiation and elongation during chromosome replication
AKN90_10010	COG0138	bifunctional purine biosynthesis protein purh
AKN90_10040	COG2135	peptidase activity
AKN90_10050	COG1660	Displays ATPase and GTPase activities
AKN90_10065	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
AKN90_10130	COG3201	nicotinamide mononucleotide transporter
AKN90_10140	COG1846	Transcriptional regulator
AKN90_10150	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
AKN90_10165	COG1805	sodium ion transport
AKN90_10190	COG1477	protein flavinylation
AKN90_10200	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AKN90_10210	COG4591	ABC-type transport system involved in lipoprotein release permease component
AKN90_10225	COG0436	Aminotransferase
AKN90_10230	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AKN90_10240	COG4536	flavin adenine dinucleotide binding
AKN90_10250	COG1399	metal-binding, possibly nucleic acid-binding protein
AKN90_10255	COG0333	Belongs to the bacterial ribosomal protein bL32 family
AKN90_10260	COG0416	fatty acid biosynthetic process
AKN90_10275	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
AKN90_10280	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
AKN90_10285	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
AKN90_10290	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
AKN90_10295	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
AKN90_10310	COG0084	hydrolase, TatD family'
AKN90_10315	COG1643	Atp-dependent helicase
AKN90_10320	COG0826	peptidase U32
AKN90_10330	COG1214	PFAM Peptidase M22, glycoprotease
AKN90_10335	COG0742	ribosomal rna small subunit methyltransferase
AKN90_10355	COG0564	pseudouridine synthase activity
AKN90_10370	COG3720	iron ion transport
AKN90_10385	COG0848	biopolymer transport protein
AKN90_10390	COG4558	Periplasmic binding protein
AKN90_10395	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AKN90_10400	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
AKN90_10420	COG0165	Argininosuccinate lyase
AKN90_10430	COG0530	calcium, potassium:sodium antiporter activity
AKN90_10435	COG0471	metal ion transport
AKN90_10440	COG0513	Belongs to the DEAD box helicase family
AKN90_10455	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
AKN90_10470	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
AKN90_10520	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AKN90_10540	COG0489	protein tyrosine kinase activity
AKN90_10540	COG3206	protein involved in exopolysaccharide biosynthesis
AKN90_10620	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
AKN90_10680	COG1968	undecaprenyl-diphosphatase activity
AKN90_10710	COG0542	response to heat
AKN90_10715	COG0586	Pfam SNARE associated Golgi protein
AKN90_10720	COG2094	Belongs to the DNA glycosylase MPG family
AKN90_10725	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
AKN90_10730	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
AKN90_10745	COG0768	penicillin binding
AKN90_10750	COG0772	Belongs to the SEDS family
AKN90_10755	COG2951	lytic endotransglycosylase activity
AKN90_10765	COG1686	Belongs to the peptidase S11 family
AKN90_10775	COG0321	lipoyl(octanoyl) transferase activity
AKN90_10780	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
AKN90_10790	COG2264	protein methyltransferase activity
AKN90_10815	COG0730	response to heat
AKN90_10820	COG0514	ATP-dependent DNA helicase (RecQ)
AKN90_10825	COG2076	Multidrug Resistance protein
AKN90_10835	COG5592	hemerythrin HHE cation binding domain
AKN90_10840	COG0602	queuosine metabolic process
AKN90_10845	COG0720	synthase
AKN90_10865	COG2823	Periplasmic or secreted lipoprotein
AKN90_10870	COG0363	glucosamine-6-phosphate deaminase activity
AKN90_10885	COG2967	ApaG domain
AKN90_10890	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
AKN90_10895	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AKN90_10905	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
AKN90_10915	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
AKN90_10925	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
AKN90_10930	COG0795	lipopolysaccharide-transporting ATPase activity
AKN90_10935	COG0795	lipopolysaccharide-transporting ATPase activity
AKN90_10940	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
AKN90_10945	COG2027	D-alanyl-D-alanine carboxypeptidase
AKN90_10955	COG2847	Copper chaperone PCu(A)C
AKN90_10960	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
AKN90_10965	COG0542	response to heat
AKN90_10980	COG2030	dehydratase
AKN90_10985	COG0318	PFAM AMP-dependent synthetase and ligase
AKN90_10995	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
AKN90_11000	COG0542	response to heat
AKN90_11015	COG2030	dehydratase
AKN90_11020	COG0318	PFAM AMP-dependent synthetase and ligase
AKN90_11025	COG0589	response to stress
AKN90_11030	COG1252	NADH dehydrogenase
AKN90_11040	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
AKN90_11050	COG0148	phosphopyruvate hydratase activity
AKN90_11055	COG2877	3-deoxy-8-phosphooctulonate synthase activity
AKN90_11060	COG0504	CTP synthase activity
AKN90_11085	COG1199	ATP-dependent helicase activity
AKN90_11095	COG0167	dihydroorotate dehydrogenase activity
AKN90_11100	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AKN90_11110	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AKN90_11120	COG3243	poly(R)-hydroxyalkanoic acid synthase
AKN90_11130	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
AKN90_11145	COG0800	Aldolase
AKN90_11160	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
AKN90_11165	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
AKN90_11170	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
AKN90_11185	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
AKN90_11190	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
AKN90_11205	COG2989	Protein conserved in bacteria
AKN90_11210	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
AKN90_11220	COG0291	Belongs to the bacterial ribosomal protein bL35 family
AKN90_11225	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
AKN90_11230	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
AKN90_11235	COG0072	phenylalanine-tRNA ligase activity
AKN90_11240	COG0776	regulation of translation
AKN90_11275	COG0693	protein deglycase activity
AKN90_11285	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress