locus-tag	class	description
AKN89_00015	COG0189	ligase activity
AKN89_00030	COG2223	nitrite transmembrane transporter activity
AKN89_00050	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
AKN89_00060	COG2321	neutral zinc metallopeptidase
AKN89_00065	COG4988	ABC transporter
AKN89_00070	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
AKN89_00080	COG0328	RNA-DNA hybrid ribonuclease activity
AKN89_00085	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
AKN89_00155	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
AKN89_00165	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
AKN89_00170	COG1115	amino acid carrier protein
AKN89_00190	COG0425	Belongs to the sulfur carrier protein TusA family
AKN89_00195	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
AKN89_00200	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
AKN89_00220	COG0308	aminopeptidase N
AKN89_00235	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
AKN89_00250	COG1335	isochorismatase
AKN89_00255	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
AKN89_00260	COG4181	ATPase activity
AKN89_00275	COG0402	S-adenosylhomocysteine deaminase activity
AKN89_00315	COG0418	dihydroorotase activity
AKN89_00320	COG0137	argininosuccinate synthase activity
AKN89_00325	COG0346	lactoylglutathione lyase activity
AKN89_00340	COG1028	Short-chain dehydrogenase reductase Sdr
AKN89_00350	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
AKN89_00355	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
AKN89_00360	COG2252	PERMEase
AKN89_00375	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
AKN89_00380	COG0066	3-isopropylmalate dehydratase activity
AKN89_00405	COG0668	transmembrane transport
AKN89_00410	COG4133	protoheme IX ABC transporter activity
AKN89_00435	COG1138	Cytochrome C-type biogenesis protein
AKN89_00455	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
AKN89_00475	COG3133	Outer membrane lipoprotein
AKN89_00520	COG1025	Belongs to the peptidase M16 family
AKN89_00525	COG0116	Belongs to the methyltransferase superfamily
AKN89_00525	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
AKN89_00550	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
AKN89_00585	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
AKN89_00590	COG1074	ATP-dependent DNA helicase activity
AKN89_00595	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
AKN89_00600	COG0393	Putative heavy-metal-binding
AKN89_00610	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
AKN89_00635	COG1024	Enoyl-CoA hydratase
AKN89_00650	COG2204	response regulator
AKN89_00655	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AKN89_00655	COG4191	Histidine kinase
AKN89_00685	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AKN89_00690	COG0481	GTPase activity
AKN89_00700	COG0571	ribonuclease III activity
AKN89_00705	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
AKN89_00710	COG1381	Involved in DNA repair and RecF pathway recombination
AKN89_00715	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
AKN89_00735	COG1131	(ABC) transporter
AKN89_00740	COG0842	Transport permease protein
AKN89_00745	COG0791	NLP P60 protein
AKN89_00750	COG0791	NLP P60 protein
AKN89_00755	COG0133	tryptophan synthase activity
AKN89_00765	COG0642	Histidine kinase
AKN89_00775	COG0745	RESPONSE REGULATOR receiver
AKN89_00780	COG2350	Protein conserved in bacteria
AKN89_00785	COG2917	probably involved in intracellular septation
AKN89_00790	COG0613	PHP domain protein
AKN89_00795	COG0009	L-threonylcarbamoyladenylate synthase
AKN89_00800	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
AKN89_00805	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
AKN89_00815	COG0535	radical SAM domain protein
AKN89_00825	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
AKN89_00880	COG2205	protein histidine kinase activity
AKN89_00880	COG0784	Response regulator, receiver
AKN89_00900	COG1397	ADP-ribosylglycohydrolase
AKN89_00905	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
AKN89_00915	COG0419	ATPase involved in DNA repair
AKN89_00920	COG0420	3'-5' exonuclease activity
AKN89_00930	COG0628	permease
AKN89_00940	COG0625	glutathione transferase activity
AKN89_00960	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
AKN89_00970	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
AKN89_00980	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AKN89_00985	COG2814	Major facilitator Superfamily
AKN89_01005	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
AKN89_01010	COG0585	pseudouridine synthase activity
AKN89_01015	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
AKN89_01025	COG2911	Protein conserved in bacteria
AKN89_01030	COG0729	surface antigen
AKN89_01035	COG0708	Exodeoxyribonuclease III
AKN89_01040	COG3781	membrane
AKN89_01045	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
AKN89_01050	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
AKN89_01075	COG0037	tRNA processing
AKN89_01095	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
AKN89_01105	COG0560	Phosphoserine phosphatase
AKN89_01135	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AKN89_01150	COG4953	penicillin-binding protein 1C
AKN89_01160	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
AKN89_01165	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
AKN89_01170	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
AKN89_01175	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
AKN89_01180	COG5007	Belongs to the BolA IbaG family
AKN89_01200	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
AKN89_01205	COG1127	ABC transporter
AKN89_01215	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
AKN89_01225	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
AKN89_01230	COG1137	ATPase activity
AKN89_01245	COG1132	(ABC) transporter
AKN89_01260	COG0730	response to heat
AKN89_01275	COG1024	Enoyl-CoA hydratase
AKN89_01280	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
AKN89_01290	COG2010	Cytochrome c
AKN89_01295	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
AKN89_01295	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AKN89_01300	COG0023	Translation Initiation Factor
AKN89_01305	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AKN89_01310	COG0069	glutamate synthase activity
AKN89_01315	COG2119	membrane
AKN89_01320	COG5394	Polyhydroxyalkanoate synthesis repressor PhaR
AKN89_01325	COG0675	Transposase, IS605 OrfB family
AKN89_01350	COG1335	isochorismatase
AKN89_01410	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AKN89_01415	COG2373	Large extracellular alpha-helical protein
AKN89_01430	COG0433	COG0433 Predicted ATPase
AKN89_01435	COG0788	formyltetrahydrofolate deformylase activity
AKN89_01440	COG2853	Lipoprotein
AKN89_01445	COG0215	cysteine-tRNA ligase activity
AKN89_01450	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AKN89_01455	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
AKN89_01460	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AKN89_01465	COG2031	fatty acid transporter
AKN89_01470	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
AKN89_01475	COG3115	cell septum assembly
AKN89_01480	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
AKN89_01485	COG2824	Alkylphosphonate utilization operon protein PhnA
AKN89_01495	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
AKN89_01500	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
AKN89_01505	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
AKN89_01510	COG1605	Chorismate mutase
AKN89_01510	COG0077	Prephenate dehydratase
AKN89_01525	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
AKN89_01530	COG1132	(ABC) transporter
AKN89_01550	COG0271	Belongs to the BolA IbaG family
AKN89_01580	COG0848	biopolymer transport protein
AKN89_01585	COG0811	peptide transport
AKN89_01590	COG0811	peptide transport
AKN89_01600	COG0121	glutamine amidotransferase
AKN89_01610	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
AKN89_01640	COG0730	response to heat
AKN89_01645	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
AKN89_01650	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
AKN89_01660	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
AKN89_01665	COG4208	sulfate ABC transporter
AKN89_01675	COG0469	pyruvate kinase activity
AKN89_01680	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
AKN89_01685	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
AKN89_01690	COG3842	ATPase activity
AKN89_01710	COG2885	chlorophyll binding
AKN89_01720	COG0427	acetyl-CoA hydrolase
AKN89_01745	COG0513	Belongs to the DEAD box helicase family
AKN89_01760	COG2212	antiporter activity
AKN89_01770	COG0651	ATP synthesis coupled electron transport
AKN89_01775	COG1006	Multisubunit Na H antiporter MnhC subunit
AKN89_01780	COG2111	Na H antiporter
AKN89_01780	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
AKN89_01785	COG0604	alcohol dehydrogenase
AKN89_01800	COG0556	nucleotide-excision repair
AKN89_01810	COG1136	(ABC) transporter
AKN89_01825	COG2996	Protein conserved in bacteria
AKN89_01835	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AKN89_01840	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AKN89_01845	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
AKN89_01850	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AKN89_01870	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
AKN89_01880	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
AKN89_01885	COG0233	cytoplasmic translational termination
AKN89_01890	COG0528	UMP kinase activity
AKN89_01895	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
AKN89_01900	COG0052	Belongs to the universal ribosomal protein uS2 family
AKN89_01905	COG0024	Methionine aminopeptidase
AKN89_01910	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
AKN89_01915	COG1393	Belongs to the ArsC family
AKN89_01920	COG2171	N-acyltransferase activity
AKN89_01925	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
AKN89_01930	COG2166	iron-sulfur cluster assembly
AKN89_01965	COG2814	Major facilitator Superfamily
AKN89_01975	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
AKN89_01980	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
AKN89_01990	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
AKN89_01995	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
AKN89_02005	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
AKN89_02010	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
AKN89_02025	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
AKN89_02040	COG0604	alcohol dehydrogenase
AKN89_02045	COG0616	signal peptide processing
AKN89_02070	COG0812	UDP-N-acetylmuramate dehydrogenase activity
AKN89_02075	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
AKN89_02080	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
AKN89_02085	COG2835	tetraacyldisaccharide 4'-kinase activity
AKN89_02090	COG1663	tetraacyldisaccharide 4'-kinase activity
AKN89_02095	COG0658	competence protein
AKN89_02095	COG2333	competence protein COMEC
AKN89_02105	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
AKN89_02115	COG5016	pyruvate
AKN89_02115	COG0511	ligase activity, forming carbon-carbon bonds
AKN89_02120	COG3630	sodium ion export across plasma membrane
AKN89_02125	COG2239	Acts as a magnesium transporter
AKN89_02155	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
AKN89_02165	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
AKN89_02175	COG0037	tRNA processing
AKN89_02180	COG2814	Major facilitator Superfamily
AKN89_02185	COG0284	orotidine-5'-phosphate decarboxylase activity
AKN89_02190	COG0114	fumarate hydratase activity
AKN89_02195	COG0730	response to heat
AKN89_02220	COG1862	Preprotein translocase
AKN89_02230	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
AKN89_02240	COG2259	Doxx family
AKN89_02245	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
AKN89_02250	COG2366	antibiotic biosynthetic process
AKN89_02255	COG2885	chlorophyll binding
AKN89_02270	COG0400	carboxylic ester hydrolase activity
AKN89_02275	COG0513	Belongs to the DEAD box helicase family
AKN89_02280	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
AKN89_02290	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AKN89_02300	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
AKN89_02305	COG0425	Belongs to the sulfur carrier protein TusA family
AKN89_02310	COG4783	chaperone-mediated protein folding
AKN89_02320	COG2814	Major facilitator Superfamily
AKN89_02325	COG2356	endonuclease I
AKN89_02335	COG1272	protein, Hemolysin III
AKN89_02350	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
AKN89_02360	COG0456	acetyltransferase
AKN89_02385	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
AKN89_02390	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AKN89_02395	COG1120	ATPase activity
AKN89_02405	COG1492	cobalamin metabolic process
AKN89_02410	COG0778	Nitroreductase
AKN89_02435	COG0583	DNA-binding transcription factor activity
AKN89_02475	COG0318	PFAM AMP-dependent synthetase and ligase
AKN89_02480	COG1960	acyl-CoA dehydrogenase activity
AKN89_02485	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
AKN89_02490	COG1250	3-hydroxyacyl-CoA dehydrogenase
AKN89_02490	COG1024	Enoyl-CoA hydratase
AKN89_02515	COG0789	Transcriptional regulator
AKN89_02520	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
AKN89_02545	COG0045	succinate-CoA ligase (ADP-forming) activity
AKN89_02565	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
AKN89_02580	COG2009	succinate dehydrogenase
AKN89_02600	COG2084	Dehydrogenase
AKN89_02610	COG3278	Belongs to the heme-copper respiratory oxidase family
AKN89_02625	COG2010	Cytochrome c
AKN89_02640	COG2217	Heavy metal translocating P-type atpase
AKN89_02660	COG0741	lytic transglycosylase activity
AKN89_02665	COG2175	clavaminate synthase activity
AKN89_02670	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AKN89_02675	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
AKN89_02680	COG4521	taurine ABC transporter
AKN89_02685	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
AKN89_02690	COG0492	ferredoxin-NADP+ reductase activity
AKN89_02710	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AKN89_02730	COG0776	regulation of translation
AKN89_02735	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
AKN89_02735	COG0316	Belongs to the HesB IscA family
AKN89_02740	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
AKN89_02760	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
AKN89_02780	COG1196	nuclear chromosome segregation
AKN89_02780	COG0741	lytic transglycosylase activity
AKN89_02780	COG0739	heme binding
AKN89_02795	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
AKN89_02800	COG0018	arginyl-trna synthetase
AKN89_02815	COG4206	TonB-dependent receptor
AKN89_02825	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
AKN89_02835	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
AKN89_02845	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
AKN89_02845	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
AKN89_02850	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
AKN89_02860	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
AKN89_02870	COG1070	Carbohydrate kinase
AKN89_02875	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
AKN89_02885	COG2207	Transcriptional regulator
AKN89_02910	COG0183	Belongs to the thiolase family
AKN89_02915	COG1024	Enoyl-CoA hydratase
AKN89_02915	COG1250	3-hydroxyacyl-CoA dehydrogenase
AKN89_02920	COG0589	response to stress
AKN89_02925	COG0405	Gamma-glutamyltransferase
AKN89_02930	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
AKN89_02935	COG0488	(ABC) transporter
AKN89_02950	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
AKN89_02955	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
AKN89_02965	COG1388	LysM domain
AKN89_02965	COG0741	lytic transglycosylase activity
AKN89_02975	COG4166	transmembrane transport
AKN89_02980	COG4174	ABC transporter (Permease)
AKN89_02985	COG4239	(ABC) transporter, permease
AKN89_02990	COG4172	Belongs to the ABC transporter superfamily
AKN89_03005	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
AKN89_03010	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
AKN89_03015	COG0482	sulfurtransferase activity
AKN89_03020	COG2915	High frequency lysogenization protein hflD homolog
AKN89_03025	COG0697	spore germination
AKN89_03035	COG2850	peptidyl-arginine hydroxylation
AKN89_03040	COG2153	protein acetylation
AKN89_03055	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
AKN89_03065	COG2226	methyltransferase
AKN89_03080	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
AKN89_03095	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
AKN89_03100	COG2860	membrane
AKN89_03145	COG1132	(ABC) transporter
AKN89_03150	COG3284	Transcriptional regulator
AKN89_03185	COG1132	(ABC) transporter
AKN89_03225	COG0435	Glutathione S-transferase
AKN89_03240	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
AKN89_03250	COG3223	Belongs to the PsiE family
AKN89_03265	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
AKN89_03285	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
AKN89_03295	COG3107	peptidoglycan biosynthetic process
AKN89_03300	COG0792	nuclease activity
AKN89_03310	COG2823	Periplasmic or secreted lipoprotein
AKN89_03320	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
AKN89_03330	COG0336	Belongs to the RNA methyltransferase TrmD family
AKN89_03335	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
AKN89_03345	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
AKN89_03350	COG0424	maF-like protein
AKN89_03370	COG1530	ribonuclease E activity
AKN89_03375	COG1902	pentaerythritol trinitrate reductase activity
AKN89_03375	COG0446	pyridine nucleotide-disulphide oxidoreductase
AKN89_03410	COG1160	GTP binding
AKN89_03425	COG0124	histidyl-tRNA synthetase
AKN89_03430	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
AKN89_03470	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
AKN89_03475	COG0316	Belongs to the HesB IscA family
AKN89_03485	COG1104	cysteine desulfurase activity
AKN89_03510	COG0436	Aminotransferase
AKN89_03525	COG3091	SprT-like family
AKN89_03530	COG0501	Belongs to the peptidase M48B family
AKN89_03540	COG1185	polyribonucleotide nucleotidyltransferase activity
AKN89_03545	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
AKN89_03550	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
AKN89_03555	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
AKN89_03560	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
AKN89_03565	COG0195	Participates in both transcription termination and antitermination
AKN89_03570	COG0779	Required for maturation of 30S ribosomal subunits
AKN89_03585	COG0149	triose-phosphate isomerase activity
AKN89_03590	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AKN89_03595	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
AKN89_03620	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
AKN89_03640	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
AKN89_03645	COG0484	heat shock protein binding
AKN89_03650	COG0443	Heat shock 70 kDa protein
AKN89_03655	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
AKN89_03660	COG0497	DNA recombination
AKN89_03670	COG1530	ribonuclease E activity
AKN89_03675	COG0424	maF-like protein
AKN89_03690	COG1077	Cell shape determining protein MreB Mrl
AKN89_03695	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
AKN89_03705	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
AKN89_03710	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
AKN89_03720	COG1252	NADH dehydrogenase
AKN89_03730	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
AKN89_03740	COG1215	transferase activity, transferring glycosyl groups
AKN89_03755	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
AKN89_03765	COG2244	polysaccharide biosynthetic process
AKN89_03785	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
AKN89_03810	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
AKN89_03815	COG2755	lipolytic protein G-D-S-L family
AKN89_03815	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
AKN89_03825	COG0438	transferase activity, transferring glycosyl groups
AKN89_03845	COG0438	transferase activity, transferring glycosyl groups
AKN89_03850	COG2192	nodulation
AKN89_03875	COG0438	transferase activity, transferring glycosyl groups
AKN89_03880	COG0859	PFAM glycosyl transferase family 9
AKN89_03885	COG0859	PFAM glycosyl transferase family 9
AKN89_03895	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AKN89_03925	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
AKN89_03970	COG0582	viral genome integration into host DNA
AKN89_04010	COG1595	DNA-templated transcription, initiation
AKN89_04025	COG0798	PFAM Bile acid sodium symporter
AKN89_04030	COG0431	NADPH-dependent FMN reductase
AKN89_04040	COG0659	secondary active sulfate transmembrane transporter activity
AKN89_04090	COG0717	Belongs to the dCTP deaminase family
AKN89_04095	COG1278	Cold shock
AKN89_04100	COG0489	protein tyrosine kinase activity
AKN89_04115	COG2853	Lipoprotein
AKN89_04125	COG1560	Kdo2-lipid A biosynthetic process
AKN89_04130	COG0850	regulation of cytokinetic process
AKN89_04135	COG2894	cell division
AKN89_04140	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
AKN89_04145	COG0564	pseudouridine synthase activity
AKN89_04150	COG0714	Associated with various cellular activities
AKN89_04180	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AKN89_04190	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
AKN89_04195	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
AKN89_04210	COG1555	photosystem II stabilization
AKN89_04215	COG3100	YcgL domain-containing protein
AKN89_04230	COG0322	excinuclease ABC activity
AKN89_04240	COG4574	serine-type endopeptidase inhibitor activity
AKN89_04265	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
AKN89_04270	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
AKN89_04270	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
AKN89_04280	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
AKN89_04295	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
AKN89_04300	COG1047	Peptidyl-prolyl cis-trans
AKN89_04310	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
AKN89_04315	COG0196	riboflavin kinase activity
AKN89_04320	COG0728	peptidoglycan biosynthetic process
AKN89_04325	COG0268	Binds directly to 16S ribosomal RNA
AKN89_04330	COG3258	Cytochrome c
AKN89_04340	COG3122	Protein conserved in bacteria
AKN89_04345	COG3956	TIGRFAM MazG family protein
AKN89_04350	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
AKN89_04355	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
AKN89_04380	COG0181	hydroxymethylbilane synthase activity
AKN89_04405	COG0488	(ABC) transporter
AKN89_04415	COG0861	Integral membrane protein TerC family
AKN89_04425	COG1607	acyl-coa hydrolase
AKN89_04435	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
AKN89_04440	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
AKN89_04445	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
AKN89_04450	COG0671	phosphoesterase, PA-phosphatase related
AKN89_04455	COG1028	Short-chain dehydrogenase reductase Sdr
AKN89_04465	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
AKN89_04485	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
AKN89_04490	COG0022	dehydrogenase e1 component
AKN89_04505	COG0288	reversible hydration of carbon dioxide
AKN89_04520	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AKN89_04525	COG1690	Belongs to the RtcB family
AKN89_04535	COG2873	o-acetylhomoserine
AKN89_04565	COG0183	Belongs to the thiolase family
AKN89_04570	COG0318	PFAM AMP-dependent synthetase and ligase
AKN89_04580	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AKN89_04590	COG2264	protein methyltransferase activity
AKN89_04600	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
AKN89_04605	COG0372	Belongs to the citrate synthase family
AKN89_04615	COG1802	Transcriptional regulator
AKN89_04620	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
AKN89_04645	COG1643	Atp-dependent helicase
AKN89_04655	COG0501	Belongs to the peptidase M48B family
AKN89_04660	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
AKN89_04670	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
AKN89_04675	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
AKN89_04695	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AKN89_04705	COG4657	Part of a membrane complex involved in electron transport
AKN89_04710	COG2878	Part of a membrane complex involved in electron transport
AKN89_04720	COG4658	electron transport chain
AKN89_04725	COG4659	FMN binding
AKN89_04740	COG1301	dicarboxylic acid transport
AKN89_04750	COG4989	oxidoreductase activity
AKN89_04755	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
AKN89_04755	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
AKN89_04760	COG1346	cytolysis
AKN89_04775	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
AKN89_04780	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
AKN89_04785	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
AKN89_04800	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
AKN89_04825	COG0617	tRNA 3'-terminal CCA addition
AKN89_04830	COG4566	intracellular signal transduction
AKN89_04835	COG4191	Histidine kinase
AKN89_04840	COG0318	PFAM AMP-dependent synthetase and ligase
AKN89_04850	COG1960	acyl-CoA dehydrogenase activity
AKN89_04865	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
AKN89_04870	COG0113	porphobilinogen synthase activity
AKN89_04875	COG1917	Cupin 2, conserved barrel domain protein
AKN89_04875	COG2207	Transcriptional regulator
AKN89_04880	COG0697	spore germination
AKN89_04905	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
AKN89_04915	COG2176	DNA-directed DNA polymerase activity
AKN89_04920	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
AKN89_04945	COG0676	glucose-6-phosphate 1-epimerase activity
AKN89_04950	COG3264	Mechanosensitive ion channel
AKN89_04950	COG1196	nuclear chromosome segregation
AKN89_04955	COG3263	regulation of cellular component size
AKN89_04965	COG2081	HI0933 family
AKN89_04980	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
AKN89_05000	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
AKN89_05010	COG0203	ribosomal protein L17
AKN89_05015	COG0202	RNA polymerase activity
AKN89_05020	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
AKN89_05025	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
AKN89_05040	COG0200	Binds to the 23S rRNA
AKN89_05045	COG1841	ribosomal large subunit assembly
AKN89_05050	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
AKN89_05055	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
AKN89_05060	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
AKN89_05065	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
AKN89_05070	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
AKN89_05080	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
AKN89_05085	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
AKN89_05090	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
AKN89_05095	COG0255	Belongs to the universal ribosomal protein uL29 family
AKN89_05105	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
AKN89_05110	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
AKN89_05115	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
AKN89_05120	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
AKN89_05130	COG0088	Forms part of the polypeptide exit tunnel
AKN89_05135	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
AKN89_05140	COG0051	transcription antitermination factor activity, RNA binding
AKN89_05145	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
AKN89_05150	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
AKN89_05155	COG0049	tRNA binding
AKN89_05160	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
AKN89_05170	COG0085	RNA polymerase activity
AKN89_05175	COG0222	ribosome binding
AKN89_05180	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
AKN89_05185	COG0081	regulation of translation
AKN89_05190	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
AKN89_05210	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
AKN89_05230	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
AKN89_05235	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
AKN89_05235	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
AKN89_05265	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
AKN89_05270	COG0739	heme binding
AKN89_05275	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
AKN89_05280	COG0316	Belongs to the HesB IscA family
AKN89_05285	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
AKN89_05290	COG1981	membrane
AKN89_05295	COG0537	adenosine 5'-monophosphoramidase activity
AKN89_05300	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
AKN89_05305	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
AKN89_05310	COG1765	OsmC-like protein
AKN89_05320	COG2011	ABC-type metal ion transport system permease component
AKN89_05335	COG1108	ABC-type Mn2 Zn2 transport systems permease components
AKN89_05340	COG1121	(ABC) transporter
AKN89_05345	COG0735	belongs to the Fur family
AKN89_05350	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
AKN89_05365	COG2183	response to ionizing radiation
AKN89_05370	COG2918	glutathione biosynthetic process
AKN89_05380	COG0488	(ABC) transporter
AKN89_05385	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
AKN89_05390	COG1490	D-aminoacyl-tRNA deacylase activity
AKN89_05395	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
AKN89_05400	COG3047	cAMP biosynthetic process
AKN89_05405	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AKN89_05415	COG0501	Belongs to the peptidase M48B family
AKN89_05425	COG1519	Transferase
AKN89_05430	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
AKN89_05435	COG4191	Histidine kinase
AKN89_05445	COG4771	TonB-dependent receptor
AKN89_05470	COG0019	diaminopimelate decarboxylase activity
AKN89_05475	COG1028	Short-chain dehydrogenase reductase Sdr
AKN89_05480	COG1028	Short-chain dehydrogenase reductase Sdr
AKN89_05490	COG0606	chelatase, subunit chli
AKN89_05495	COG2863	cytochrome
AKN89_05500	COG3258	Cytochrome c
AKN89_05515	COG3161	chorismate lyase activity
AKN89_05520	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
AKN89_05535	COG0347	Belongs to the P(II) protein family
AKN89_05555	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
AKN89_05560	COG0751	glycine-tRNA ligase activity
AKN89_05580	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
AKN89_05595	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
AKN89_05600	COG0583	DNA-binding transcription factor activity
AKN89_05615	COG0635	Involved in the biosynthesis of porphyrin-containing compound
AKN89_05630	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
AKN89_05630	COG2813	Specifically methylates the guanine in position
AKN89_05635	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
AKN89_05640	COG1872	DUF167
AKN89_05670	COG1011	Hydrolase
AKN89_05675	COG0494	nUDIX hydrolase
AKN89_05685	COG3204	pilus organization
AKN89_05690	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
AKN89_05700	COG0540	Belongs to the ATCase OTCase family
AKN89_05710	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
AKN89_05725	COG0745	RESPONSE REGULATOR receiver
AKN89_05770	COG0330	HflC and HflK could
AKN89_05780	COG1392	Phosphate transport regulator
AKN89_05785	COG0306	phosphate transporter
AKN89_05810	COG0523	cobalamin synthesis protein
AKN89_05840	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
AKN89_05850	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
AKN89_05855	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
AKN89_05860	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
AKN89_05865	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
AKN89_05875	COG1648	precorrin-2 dehydrogenase activity
AKN89_05875	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
AKN89_05880	COG0175	sulfate reduction
AKN89_05900	COG0071	Belongs to the small heat shock protein (HSP20) family
AKN89_05905	COG1451	nucleotide metabolic process
AKN89_05915	COG0084	hydrolase, TatD family'
AKN89_05945	COG1368	sulfuric ester hydrolase activity
AKN89_05950	COG0745	RESPONSE REGULATOR receiver
AKN89_05955	COG0642	Histidine kinase
AKN89_05960	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
AKN89_05970	COG2207	Transcriptional regulator
AKN89_05975	COG1944	ATP diphosphatase activity
AKN89_05980	COG1289	transmembrane transporter activity
AKN89_05985	COG3038	cytochrome b561
AKN89_05995	COG3384	dioxygenase
AKN89_06000	COG0583	DNA-binding transcription factor activity
AKN89_06005	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
AKN89_06015	COG1960	acyl-CoA dehydrogenase activity
AKN89_06025	COG0133	tryptophan synthase activity
AKN89_06030	COG0159	tryptophan synthase activity
AKN89_06040	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AKN89_06055	COG0642	Histidine kinase
AKN89_06065	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
AKN89_06070	COG0592	DNA-directed DNA polymerase activity
AKN89_06075	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
AKN89_06085	COG0248	Ppx GppA phosphatase
AKN89_06100	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
AKN89_06115	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
AKN89_06120	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
AKN89_06140	COG0220	tRNA (guanine-N7-)-methyltransferase activity
AKN89_06145	COG2022	thiamine diphosphate biosynthetic process
AKN89_06155	COG2363	Small membrane protein
AKN89_06165	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
AKN89_06185	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
AKN89_06190	COG1758	RNA polymerase activity
AKN89_06205	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
AKN89_06245	COG0230	Belongs to the bacterial ribosomal protein bL34 family
AKN89_06250	COG0594	ribonuclease P activity
AKN89_06255	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
AKN89_06265	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
AKN89_06280	COG1192	Involved in chromosome partitioning
AKN89_06285	COG1475	DNA binding
AKN89_06295	COG0356	it plays a direct role in the translocation of protons across the membrane
AKN89_06305	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
AKN89_06310	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
AKN89_06315	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
AKN89_06320	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
AKN89_06325	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
AKN89_06330	COG0355	proton-transporting ATP synthase activity, rotational mechanism
AKN89_06335	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
AKN89_06345	COG3023	N-Acetylmuramoyl-L-alanine amidase
AKN89_06350	COG0700	Nucleoside recognition
AKN89_06410	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
AKN89_06415	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
AKN89_06420	COG0513	Belongs to the DEAD box helicase family
AKN89_06425	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
AKN89_06445	COG0742	ribosomal rna small subunit methyltransferase
AKN89_06460	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
AKN89_06470	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
AKN89_06470	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
AKN89_06480	COG0404	The glycine cleavage system catalyzes the degradation of glycine
AKN89_06485	COG1178	ABC-type Fe3 transport system permease component
AKN89_06490	COG3135	benzoate transporter
AKN89_06505	COG0129	dihydroxy-acid dehydratase activity
AKN89_06510	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
AKN89_06525	COG0789	Transcriptional regulator
AKN89_06535	COG0617	tRNA 3'-terminal CCA addition
AKN89_06535	COG3620	sequence-specific DNA binding
AKN89_06535	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
AKN89_06540	COG1132	(ABC) transporter
AKN89_06570	COG0252	asparaginase activity
AKN89_06575	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
AKN89_06580	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
AKN89_06595	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
AKN89_06610	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
AKN89_06615	COG0826	peptidase U32
AKN89_06620	COG0826	peptidase U32
AKN89_06625	COG3154	lipid carrier protein
AKN89_06645	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
AKN89_06650	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
AKN89_06655	COG0730	response to heat
AKN89_06660	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
AKN89_06685	COG1966	Carbon starvation protein
AKN89_06695	COG0003	Pfam Anion-transporting ATPase
AKN89_06700	COG1285	pathogenesis
AKN89_06705	COG2239	Acts as a magnesium transporter
AKN89_06710	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
AKN89_06720	COG0009	L-threonylcarbamoyladenylate synthase
AKN89_06725	COG0758	DNA mediated transformation
AKN89_06735	COG0242	peptide deformylase activity
AKN89_06740	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
AKN89_06750	COG0569	domain protein
AKN89_06755	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
AKN89_06765	COG0318	PFAM AMP-dependent synthetase and ligase
AKN89_06775	COG0826	peptidase U32
AKN89_06785	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
AKN89_06810	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
AKN89_06815	COG4628	conserved protein (DUF2132)
AKN89_06820	COG1561	YicC-like family, N-terminal region
AKN89_06835	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
AKN89_06845	COG1196	nuclear chromosome segregation
AKN89_06895	COG2226	methyltransferase
AKN89_06895	COG1073	alpha beta
AKN89_06900	COG0156	8-amino-7-oxononanoate synthase activity
AKN89_06905	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
AKN89_06925	COG1040	competence protein
AKN89_06935	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
AKN89_06940	COG0126	phosphoglycerate kinase activity
AKN89_06950	COG2193	ferroxidase activity
AKN89_06955	COG3241	Transfers electrons from cytochrome c551 to cytochrome oxidase
AKN89_06960	COG3038	cytochrome b561
AKN89_06965	COG2353	YceI-like domain
AKN89_06980	COG1858	cytochrome C peroxidase
AKN89_06995	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
AKN89_07000	COG1194	a g-specific adenine glycosylase
AKN89_07015	COG0131	Imidazoleglycerol-phosphate dehydratase
AKN89_07040	COG0793	Belongs to the peptidase S41A family
AKN89_07045	COG4942	peptidase
AKN89_07055	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
AKN89_07060	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AKN89_07070	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
AKN89_07075	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
AKN89_07085	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
AKN89_07110	COG1652	LysM domain
AKN89_07115	COG3909	cytochrome
AKN89_07130	COG3842	ATPase activity
AKN89_07135	COG1176	ABC-type spermidine putrescine transport system, permease component I
AKN89_07140	COG1177	transmembrane transport
AKN89_07155	COG1368	sulfuric ester hydrolase activity
AKN89_07160	COG0814	amino acid
AKN89_07175	COG0583	DNA-binding transcription factor activity
AKN89_07180	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
AKN89_07185	COG1979	alcohol dehydrogenase
AKN89_07195	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
AKN89_07205	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
AKN89_07205	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
AKN89_07220	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
AKN89_07230	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AKN89_07240	COG4771	TonB-dependent receptor
AKN89_07250	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
AKN89_07255	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AKN89_07260	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AKN89_07265	COG1120	ATPase activity
AKN89_07280	COG1960	acyl-CoA dehydrogenase activity
AKN89_07290	COG1385	rRNA (uridine-N3-)-methyltransferase activity
AKN89_07300	COG0494	nUDIX hydrolase
AKN89_07325	COG1160	GTP binding
AKN89_07345	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
AKN89_07355	COG0756	dUTP diphosphatase activity
AKN89_07360	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
AKN89_07365	COG2003	Belongs to the UPF0758 family
AKN89_07370	COG0227	Belongs to the bacterial ribosomal protein bL28 family
AKN89_07375	COG0267	Belongs to the bacterial ribosomal protein bL33 family
AKN89_07385	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AKN89_07390	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
AKN89_07415	COG0523	cobalamin synthesis protein
AKN89_07425	COG0753	catalase activity
AKN89_07435	COG2814	Major facilitator Superfamily
AKN89_07445	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
AKN89_07450	COG0277	FAD linked oxidase domain protein
AKN89_07455	COG0179	Fumarylacetoacetate (FAA) hydrolase
AKN89_07465	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AKN89_07520	COG5002	protein histidine kinase activity
AKN89_07550	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
AKN89_07570	COG2003	Belongs to the UPF0758 family
AKN89_07615	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AKN89_07620	COG3177	Filamentation induced by cAMP protein fic
AKN89_07805	COG4771	TonB-dependent receptor
AKN89_07815	COG1595	DNA-templated transcription, initiation
AKN89_07820	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
AKN89_07885	COG0305	Participates in initiation and elongation during chromosome replication
AKN89_07890	COG1192	Involved in chromosome partitioning
AKN89_07895	COG1752	Esterase of the alpha-beta hydrolase superfamily
AKN89_07910	COG0427	acetyl-CoA hydrolase
AKN89_07920	COG1538	Outer membrane efflux protein
AKN89_07925	COG2274	protein secretion by the type I secretion system
AKN89_07930	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AKN89_07945	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
AKN89_07950	COG0254	rRNA binding
AKN89_07955	COG0281	malic enzyme
AKN89_07990	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
AKN89_07995	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
AKN89_08015	COG0581	inorganic phosphate transmembrane transporter activity
AKN89_08020	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
AKN89_08025	COG0704	Plays a role in the regulation of phosphate uptake
AKN89_08030	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
AKN89_08035	COG1012	belongs to the aldehyde dehydrogenase family
AKN89_08040	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
AKN89_08060	COG0301	tRNA thio-modification
AKN89_08060	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AKN89_08065	COG1217	gtp-binding protein TYPA
AKN89_08075	COG0494	nUDIX hydrolase
AKN89_08095	COG3098	single-species biofilm formation
AKN89_08110	COG0204	Acyl-transferase
AKN89_08120	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
AKN89_08150	COG3150	esterase
AKN89_08170	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
AKN89_08180	COG3008	intermembrane lipid transfer
AKN89_08180	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
AKN89_08190	COG3830	Belongs to the UPF0237 family
AKN89_08190	COG0560	Phosphoserine phosphatase
AKN89_08195	COG2732	(Barnase) inhibitor
AKN89_08215	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AKN89_08225	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AKN89_08230	COG0006	proline dipeptidase activity
AKN89_08235	COG3079	Belongs to the UPF0149 family
AKN89_08250	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
AKN89_08255	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AKN89_08260	COG0842	Transport permease protein
AKN89_08260	COG1129	ABC transporter
AKN89_08265	COG0842	Transport permease protein
AKN89_08275	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
AKN89_08280	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
AKN89_08285	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
AKN89_08290	COG3178	'Phosphotransferase
AKN89_08295	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
AKN89_08300	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
AKN89_08310	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
AKN89_08330	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AKN89_08350	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
AKN89_08355	COG1509	lysine 2,3-aminomutase activity
AKN89_08360	COG0513	Belongs to the DEAD box helicase family
AKN89_08365	COG3530	Putative quorum-sensing-regulated virulence factor
AKN89_08390	COG0142	geranyltranstransferase activity
AKN89_08395	COG1722	exodeoxyribonuclease VII activity
AKN89_08405	COG0456	acetyltransferase
AKN89_08410	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
AKN89_08440	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
AKN89_08445	COG0546	phosphoglycolate phosphatase activity
AKN89_08465	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
AKN89_08470	COG0134	indole-3-glycerol-phosphate synthase activity
AKN89_08475	COG0237	dephospho-CoA kinase activity
AKN89_08485	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
AKN89_08490	COG0490	domain, Protein
AKN89_08490	COG0471	metal ion transport
AKN89_08495	COG1122	ATPase activity
AKN89_08500	COG4120	Belongs to the binding-protein-dependent transport system permease family
AKN89_08510	COG0525	valine-tRNA ligase activity
AKN89_08520	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
AKN89_08530	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
AKN89_08540	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
AKN89_08545	COG0632	four-way junction helicase activity
AKN89_08550	COG2255	four-way junction helicase activity
AKN89_08555	COG0824	Thioesterase
AKN89_08580	COG2885	chlorophyll binding
AKN89_08585	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
AKN89_08595	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
AKN89_08600	COG1970	mechanosensitive ion channel activity
AKN89_08605	COG0142	geranyltranstransferase activity
AKN89_08610	COG0261	This protein binds to 23S rRNA in the presence of protein L20
AKN89_08615	COG0211	Belongs to the bacterial ribosomal protein bL27 family
AKN89_08620	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
AKN89_08625	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
AKN89_08655	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
AKN89_08660	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
AKN89_08665	COG0814	amino acid
AKN89_08675	COG3258	Cytochrome c
AKN89_08680	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
AKN89_08685	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
AKN89_08685	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
AKN89_08690	COG1028	Short-chain dehydrogenase reductase Sdr
AKN89_08710	COG1923	regulation of RNA biosynthetic process
AKN89_08715	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
AKN89_08720	COG0330	HflC and HflK could
AKN89_08725	COG0330	HflC and HflK could
AKN89_08730	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
AKN89_08735	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
AKN89_08760	COG0545	Peptidyl-prolyl cis-trans isomerase
AKN89_08780	COG0793	Belongs to the peptidase S41A family
AKN89_08785	COG0604	alcohol dehydrogenase
AKN89_08785	COG4221	oxidoreductase activity
AKN89_08785	COG3321	synthase
AKN89_08785	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
AKN89_08790	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
AKN89_08800	COG0633	Ferredoxin
AKN89_08805	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
AKN89_08810	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
AKN89_08815	COG3313	Fe-S protein
AKN89_08825	COG2813	Specifically methylates the guanine in position
AKN89_08830	COG3118	belongs to the thioredoxin family
AKN89_08835	COG0534	Mate efflux family protein
AKN89_08840	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
AKN89_08845	COG0778	Nitroreductase
AKN89_08875	COG1067	ATP-dependent peptidase activity
AKN89_08885	COG0789	Transcriptional regulator
AKN89_08900	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
AKN89_08905	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
AKN89_08915	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
AKN89_08920	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
AKN89_08930	COG2226	methyltransferase
AKN89_08955	COG0688	phosphatidylethanolamine metabolic process
AKN89_08960	COG1162	GTPase activity
AKN89_08965	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
AKN89_08975	COG0802	atpase or kinase
AKN89_08980	COG0860	N-Acetylmuramoyl-L-alanine amidase
AKN89_09000	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
AKN89_09010	COG0545	Peptidyl-prolyl cis-trans isomerase
AKN89_09025	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
AKN89_09035	COG0436	Aminotransferase
AKN89_09045	COG1671	Belongs to the UPF0178 family
AKN89_09050	COG1362	aminopeptidase activity
AKN89_09070	COG0166	Belongs to the GPI family
AKN89_09080	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
AKN89_09085	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
AKN89_09095	COG0617	tRNA 3'-terminal CCA addition
AKN89_09105	COG3118	belongs to the thioredoxin family
AKN89_09110	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
AKN89_09115	COG1965	Belongs to the frataxin family
AKN89_09130	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
AKN89_09145	COG1011	Hydrolase
AKN89_09165	COG0815	Transfers the fatty acyl group on membrane lipoproteins
AKN89_09180	COG1702	phosphate starvation-inducible protein PhoH
AKN89_09185	COG1538	Outer membrane efflux protein
AKN89_09190	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
AKN89_09200	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
AKN89_09205	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
AKN89_09210	COG0659	secondary active sulfate transmembrane transporter activity
AKN89_09215	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
AKN89_09220	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
AKN89_09225	COG0723	plastoquinol--plastocyanin reductase activity
AKN89_09230	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
AKN89_09235	COG2857	Cytochrome c1
AKN89_09240	COG0625	glutathione transferase activity
AKN89_09245	COG2969	positive regulation of protein catabolic process
AKN89_09290	COG2211	Major facilitator Superfamily
AKN89_09295	COG3030	protein affecting phage T7 exclusion by the F plasmid
AKN89_09300	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
AKN89_09305	COG0459	protein refolding
AKN89_09310	COG1960	acyl-CoA dehydrogenase activity
AKN89_09315	COG1024	Enoyl-CoA hydratase
AKN89_09330	COG0583	DNA-binding transcription factor activity
AKN89_09340	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AKN89_09350	COG0183	Belongs to the thiolase family
AKN89_09355	COG1024	Enoyl-CoA hydratase
AKN89_09365	COG0786	glutamate:sodium symporter activity
AKN89_09370	COG0442	prolyl-tRNA aminoacylation
AKN89_09385	COG2900	Belongs to the SlyX family
AKN89_09390	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AKN89_09405	COG0668	transmembrane transport
AKN89_09410	COG4942	peptidase
AKN89_09415	COG1570	exodeoxyribonuclease VII activity
AKN89_09420	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
AKN89_09425	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AKN89_09430	COG3162	membrane
AKN89_09440	COG1294	oxidase, subunit
AKN89_09450	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
AKN89_09460	COG1522	sequence-specific DNA binding
AKN89_09470	COG0435	Glutathione S-transferase
AKN89_09500	COG3284	Transcriptional regulator
AKN89_09515	COG2925	Exonuclease
AKN89_09530	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AKN89_09535	COG0544	peptidyl-prolyl cis-trans isomerase activity
AKN89_09545	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
AKN89_09550	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
AKN89_09560	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
AKN89_09565	COG3089	Belongs to the UPF0270 family
AKN89_09570	COG0431	NADPH-dependent FMN reductase
AKN89_09575	COG2056	Na+-H+ antiporter family
AKN89_09580	COG2837	iron assimilation
AKN89_09585	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
AKN89_09595	COG2914	Belongs to the UPF0125 (RnfH) family
AKN89_09600	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
AKN89_09610	COG2326	polyphosphate kinase activity
AKN89_09615	COG3081	Nucleoid-associated protein
AKN89_09630	COG3171	Protein conserved in bacteria
AKN89_09640	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AKN89_09660	COG2610	gluconate transmembrane transporter activity
AKN89_09670	COG2084	Dehydrogenase
AKN89_09675	COG3622	Belongs to the hyi family
AKN89_09705	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
AKN89_09710	COG0352	thiamine-phosphate diphosphorylase activity
AKN89_09715	COG0352	thiamine-phosphate diphosphorylase activity
AKN89_09715	COG0351	phosphomethylpyrimidine kinase
AKN89_09730	COG0495	leucyl-tRNA aminoacylation
AKN89_09740	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
AKN89_09740	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AKN89_09750	COG1196	nuclear chromosome segregation
AKN89_09755	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
AKN89_09760	COG1546	Belongs to the CinA family
AKN89_09770	COG2137	regulation of response to DNA damage stimulus
AKN89_09785	COG0513	Belongs to the DEAD box helicase family
AKN89_09790	COG1946	Acyl-CoA thioesterase
AKN89_09825	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
AKN89_09830	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
AKN89_09835	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
AKN89_09840	COG0772	Belongs to the SEDS family
AKN89_09850	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
AKN89_09855	COG1181	Belongs to the D-alanine--D-alanine ligase family
AKN89_09870	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
AKN89_09875	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
AKN89_09885	COG0653	protein targeting
AKN89_09890	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
AKN89_09895	COG0494	nUDIX hydrolase
AKN89_09900	COG2096	Adenosyltransferase
AKN89_09910	COG1666	GTP binding
AKN89_09920	COG0557	exoribonuclease II activity
AKN89_09925	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AKN89_09930	COG0360	Binds together with S18 to 16S ribosomal RNA
AKN89_09945	COG0359	binds to the 23S rRNA
AKN89_09950	COG0305	Participates in initiation and elongation during chromosome replication
AKN89_09970	COG0138	bifunctional purine biosynthesis protein purh
AKN89_10000	COG2135	peptidase activity
AKN89_10010	COG1660	Displays ATPase and GTPase activities
AKN89_10025	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
AKN89_10050	COG3201	nicotinamide mononucleotide transporter
AKN89_10060	COG1846	Transcriptional regulator
AKN89_10070	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
AKN89_10085	COG1805	sodium ion transport
AKN89_10110	COG1477	protein flavinylation
AKN89_10120	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AKN89_10130	COG4591	ABC-type transport system involved in lipoprotein release permease component
AKN89_10145	COG0436	Aminotransferase
AKN89_10150	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AKN89_10160	COG4536	flavin adenine dinucleotide binding
AKN89_10170	COG1399	metal-binding, possibly nucleic acid-binding protein
AKN89_10175	COG0333	Belongs to the bacterial ribosomal protein bL32 family
AKN89_10180	COG0416	fatty acid biosynthetic process
AKN89_10195	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
AKN89_10200	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
AKN89_10205	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
AKN89_10210	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
AKN89_10215	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
AKN89_10230	COG0084	hydrolase, TatD family'
AKN89_10235	COG1643	Atp-dependent helicase
AKN89_10240	COG0826	peptidase U32
AKN89_10250	COG1214	PFAM Peptidase M22, glycoprotease
AKN89_10255	COG0742	ribosomal rna small subunit methyltransferase
AKN89_10275	COG0564	pseudouridine synthase activity
AKN89_10290	COG3720	iron ion transport
AKN89_10300	COG0848	biopolymer transport protein
AKN89_10305	COG4558	Periplasmic binding protein
AKN89_10310	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AKN89_10315	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
AKN89_10335	COG0165	Argininosuccinate lyase
AKN89_10350	COG0530	calcium, potassium:sodium antiporter activity
AKN89_10355	COG0471	metal ion transport
AKN89_10360	COG0513	Belongs to the DEAD box helicase family
AKN89_10375	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
AKN89_10390	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
AKN89_10450	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AKN89_10470	COG0489	protein tyrosine kinase activity
AKN89_10470	COG3206	protein involved in exopolysaccharide biosynthesis
AKN89_10490	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
AKN89_10500	COG4558	Periplasmic binding protein
AKN89_10510	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
AKN89_10530	COG0165	Argininosuccinate lyase
AKN89_10540	COG0530	calcium, potassium:sodium antiporter activity
AKN89_10545	COG0471	metal ion transport
AKN89_10550	COG0513	Belongs to the DEAD box helicase family
AKN89_10570	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
AKN89_10585	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
AKN89_10645	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AKN89_10665	COG3206	protein involved in exopolysaccharide biosynthesis
AKN89_10665	COG0489	protein tyrosine kinase activity
AKN89_10700	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
AKN89_10705	COG0328	RNA-DNA hybrid ribonuclease activity
AKN89_10715	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
AKN89_10720	COG4988	ABC transporter
AKN89_10725	COG2321	neutral zinc metallopeptidase
AKN89_10735	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
AKN89_10755	COG2223	nitrite transmembrane transporter activity
AKN89_10770	COG0189	ligase activity
AKN89_10780	COG0542	response to heat
AKN89_10830	COG0515	serine threonine protein kinase
AKN89_10830	COG1262	PFAM Formylglycine-generating sulfatase enzyme
AKN89_10855	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
AKN89_10865	COG0693	protein deglycase activity
AKN89_10900	COG0776	regulation of translation
AKN89_10905	COG0072	phenylalanine-tRNA ligase activity
AKN89_10910	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
AKN89_10915	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
AKN89_10920	COG0291	Belongs to the bacterial ribosomal protein bL35 family
AKN89_10930	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
AKN89_10935	COG2989	Protein conserved in bacteria
AKN89_10950	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
AKN89_10955	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
AKN89_10970	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
AKN89_10975	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
AKN89_10980	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
AKN89_10995	COG0800	Aldolase
AKN89_11010	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
AKN89_11020	COG3243	poly(R)-hydroxyalkanoic acid synthase
AKN89_11030	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AKN89_11040	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AKN89_11045	COG0167	dihydroorotate dehydrogenase activity
AKN89_11055	COG1199	ATP-dependent helicase activity
AKN89_11080	COG0504	CTP synthase activity
AKN89_11085	COG2877	3-deoxy-8-phosphooctulonate synthase activity
AKN89_11090	COG0148	phosphopyruvate hydratase activity
AKN89_11100	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
AKN89_11110	COG1252	NADH dehydrogenase
AKN89_11115	COG0589	response to stress
AKN89_11120	COG0318	PFAM AMP-dependent synthetase and ligase
AKN89_11125	COG2030	dehydratase
AKN89_11140	COG0542	response to heat
AKN89_11145	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
AKN89_11150	COG1278	Cold shock
AKN89_11155	COG2847	Copper chaperone PCu(A)C
AKN89_11165	COG2027	D-alanyl-D-alanine carboxypeptidase
AKN89_11170	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
AKN89_11175	COG0795	lipopolysaccharide-transporting ATPase activity
AKN89_11180	COG0795	lipopolysaccharide-transporting ATPase activity
AKN89_11185	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
AKN89_11195	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
AKN89_11205	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
AKN89_11215	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AKN89_11220	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
AKN89_11225	COG2967	ApaG domain
AKN89_11240	COG0363	glucosamine-6-phosphate deaminase activity
AKN89_11245	COG2823	Periplasmic or secreted lipoprotein
AKN89_11265	COG0720	synthase
AKN89_11270	COG0602	queuosine metabolic process
AKN89_11275	COG5592	hemerythrin HHE cation binding domain
AKN89_11285	COG2076	Multidrug Resistance protein
AKN89_11290	COG0514	ATP-dependent DNA helicase (RecQ)
AKN89_11295	COG0730	response to heat
AKN89_11320	COG2264	protein methyltransferase activity
AKN89_11330	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
AKN89_11335	COG0321	lipoyl(octanoyl) transferase activity
AKN89_11345	COG1686	Belongs to the peptidase S11 family
AKN89_11355	COG2951	lytic endotransglycosylase activity