locus-tag	class	description
J9253_00010	COG0675	Transposase, IS605 OrfB family
J9253_00065	COG2361	Protein of unknown function DUF86
J9253_00110	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
J9253_00140	COG0318	PFAM AMP-dependent synthetase and ligase
J9253_00145	COG1028	Short-chain dehydrogenase reductase Sdr
J9253_00160	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
J9253_00195	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
J9253_00215	COG1215	transferase activity, transferring glycosyl groups
J9253_00225	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
J9253_00245	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
J9253_00260	COG2089	acid synthase
J9253_00270	COG1083	cytidylyl-transferase
J9253_00275	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
J9253_00280	COG1086	Polysaccharide biosynthesis protein
J9253_00285	COG1132	(ABC) transporter
J9253_00290	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
J9253_00295	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
J9253_00305	COG4636	protein conserved in cyanobacteria
J9253_00320	COG0601	transmembrane transport
J9253_00325	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
J9253_00340	COG2177	Part of the ABC transporter FtsEX involved in
J9253_00345	COG2884	Cell division ATP-binding protein ftsE
J9253_00350	COG0552	protein localization to endoplasmic reticulum
J9253_00355	COG0612	Peptidase, M16
J9253_00360	COG0612	Peptidase, M16
J9253_00365	COG0742	ribosomal rna small subunit methyltransferase
J9253_00370	COG0791	NLP P60 protein
J9253_00375	COG0488	(ABC) transporter
J9253_00400	COG0156	8-amino-7-oxononanoate synthase activity
J9253_00430	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
J9253_00435	COG1194	a g-specific adenine glycosylase
J9253_00445	COG0582	viral genome integration into host DNA
J9253_00565	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
J9253_00585	COG0659	secondary active sulfate transmembrane transporter activity
J9253_00610	COG0668	transmembrane transport
J9253_00620	COG3008	intermembrane lipid transfer
J9253_00625	COG2995	paraquat-inducible protein a
J9253_00640	COG1253	flavin adenine dinucleotide binding
J9253_00645	COG2239	Acts as a magnesium transporter
J9253_00650	COG0668	transmembrane transport
J9253_00655	COG2133	pyrroloquinoline quinone binding
J9253_00660	COG0471	metal ion transport
J9253_00660	COG3273	potassium ion transport
J9253_00690	COG1510	regulation of RNA biosynthetic process
J9253_00705	COG1027	Aspartate ammonia-lyase
J9253_00725	COG0778	Nitroreductase
J9253_00730	COG1733	regulation of RNA biosynthetic process
J9253_00735	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
J9253_00735	COG3153	acetyltransferase
J9253_00740	COG4067	protein conserved in archaea
J9253_00740	COG0189	ligase activity
J9253_00745	COG0189	ligase activity
J9253_00755	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
J9253_00755	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
J9253_00765	COG0561	phosphatase activity
J9253_00765	COG3100	YcgL domain-containing protein
J9253_00770	COG0438	transferase activity, transferring glycosyl groups
J9253_00775	COG1301	dicarboxylic acid transport
J9253_00785	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
J9253_00795	COG3852	Histidine kinase
J9253_00800	COG2204	response regulator
J9253_00845	COG0174	glutamine synthetase
J9253_00875	COG1611	Belongs to the LOG family
J9253_00880	COG5007	Belongs to the BolA IbaG family
J9253_00895	COG1317	bacterial-type flagellum organization
J9253_00910	COG4789	Type iii secretion
J9253_00920	COG4792	protein secretion
J9253_00925	COG4791	protein targeting
J9253_00935	COG4790	Type iii secretion
J9253_00985	COG1560	Kdo2-lipid A biosynthetic process
J9253_00995	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
J9253_01010	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
J9253_01015	COG1047	Peptidyl-prolyl cis-trans
J9253_01020	COG1560	Kdo2-lipid A biosynthetic process
J9253_01025	COG0640	Transcriptional regulator
J9253_01030	COG0701	Predicted permease
J9253_01055	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
J9253_01075	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
J9253_01075	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
J9253_01090	COG1266	CAAX protease self-immunity
J9253_01135	COG0494	nUDIX hydrolase
J9253_01200	COG3609	addiction module antidote protein, CC2985 family
J9253_01210	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
J9253_01215	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
J9253_01235	COG1028	Short-chain dehydrogenase reductase Sdr
J9253_01245	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
J9253_01255	COG0675	Transposase, IS605 OrfB family
J9253_01260	COG0675	Transposase, IS605 OrfB family
J9253_01295	COG2996	Protein conserved in bacteria
J9253_01300	COG0675	Transposase, IS605 OrfB family
J9253_01315	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
J9253_01340	COG3118	belongs to the thioredoxin family
J9253_01360	COG0667	Aldo Keto reductase
J9253_01365	COG1519	Transferase
J9253_01405	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
J9253_01410	COG1127	ABC transporter
J9253_01440	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
J9253_01455	COG0135	phosphoribosylanthranilate isomerase activity
J9253_01490	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
J9253_01525	COG0628	permease
J9253_01565	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
J9253_01595	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
J9253_01600	COG0542	response to heat
J9253_01625	COG1715	Restriction endonuclease
J9253_01640	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
J9253_01650	COG0675	Transposase, IS605 OrfB family
J9253_01655	COG0675	Transposase, IS605 OrfB family
J9253_01660	COG0589	response to stress
J9253_01675	COG2001	Belongs to the MraZ family
J9253_01680	COG0275	rRNA processing
J9253_01695	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
J9253_01700	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
J9253_01705	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
J9253_01710	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
J9253_01715	COG0772	Belongs to the SEDS family
J9253_01720	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
J9253_01725	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
J9253_01730	COG1181	Belongs to the D-alanine--D-alanine ligase family
J9253_01735	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
J9253_01745	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
J9253_01750	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
J9253_01760	COG0741	lytic transglycosylase activity
J9253_01760	COG0739	heme binding
J9253_01760	COG1196	nuclear chromosome segregation
J9253_01765	COG0653	protein targeting
J9253_01770	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
J9253_01775	COG0494	nUDIX hydrolase
J9253_01785	COG0513	Belongs to the DEAD box helicase family
J9253_01795	COG4536	flavin adenine dinucleotide binding
J9253_01800	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
J9253_01805	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
J9253_01825	COG3738	Protein conserved in bacteria
J9253_01830	COG0228	four-way junction DNA binding
J9253_01835	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
J9253_01845	COG0335	large ribosomal subunit rRNA binding
J9253_01850	COG5001	Diguanylate cyclase
J9253_01850	COG5002	protein histidine kinase activity
J9253_01855	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
J9253_01865	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
J9253_01870	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
J9253_01870	COG3266	domain, Protein
J9253_01870	COG4932	domain protein
J9253_01880	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
J9253_01885	COG2814	Major facilitator Superfamily
J9253_01890	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
J9253_01890	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
J9253_01895	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
J9253_01915	COG0598	Magnesium transport protein CorA
J9253_01925	COG1131	(ABC) transporter
J9253_01930	COG0842	Transport permease protein
J9253_01950	COG0675	Transposase, IS605 OrfB family
J9253_01960	COG1522	sequence-specific DNA binding
J9253_01975	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
J9253_01980	COG0137	argininosuccinate synthase activity
J9253_01985	COG2900	Belongs to the SlyX family
J9253_01990	COG0742	ribosomal rna small subunit methyltransferase
J9253_01995	COG2363	Small membrane protein
J9253_02000	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
J9253_02005	COG1959	2 iron, 2 sulfur cluster binding
J9253_02015	COG0033	Phosphoglucomutase
J9253_02020	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
J9253_02025	COG0709	Synthesizes selenophosphate from selenide and ATP
J9253_02030	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
J9253_02035	COG1459	type II secretion system
J9253_02060	COG0681	Belongs to the peptidase S26 family
J9253_02065	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
J9253_02065	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
J9253_02095	COG0429	hydrolase of the alpha beta-hydrolase fold
J9253_02110	COG1262	PFAM Formylglycine-generating sulfatase enzyme
J9253_02110	COG0515	serine threonine protein kinase
J9253_02115	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
J9253_02125	COG0723	plastoquinol--plastocyanin reductase activity
J9253_02130	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
J9253_02135	COG2857	Cytochrome c1
J9253_02140	COG0625	glutathione transferase activity
J9253_02145	COG2969	positive regulation of protein catabolic process
J9253_02155	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
J9253_02160	COG1262	PFAM Formylglycine-generating sulfatase enzyme
J9253_02205	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
J9253_02210	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
J9253_02220	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
J9253_02225	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
J9253_02240	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
J9253_02245	COG0193	aminoacyl-tRNA hydrolase activity
J9253_02250	COG0012	GTP binding
J9253_02260	COG2814	Major facilitator Superfamily
J9253_02295	COG3264	Mechanosensitive ion channel
J9253_02295	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
J9253_02305	COG0504	CTP synthase activity
J9253_02310	COG2877	3-deoxy-8-phosphooctulonate synthase activity
J9253_02315	COG0148	phosphopyruvate hydratase activity
J9253_02320	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
J9253_02325	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
J9253_02330	COG0247	lactate metabolic process
J9253_02335	COG0277	FAD linked oxidase domain protein
J9253_02340	COG0277	FAD linked oxidase domain protein
J9253_02345	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
J9253_02350	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
J9253_02355	COG0348	domain, Protein
J9253_02365	COG2217	Heavy metal translocating P-type atpase
J9253_02395	COG0546	phosphoglycolate phosphatase activity
J9253_02400	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
J9253_02425	COG0564	pseudouridine synthase activity
J9253_02450	COG4608	Belongs to the ABC transporter superfamily
J9253_02455	COG1846	Transcriptional regulator
J9253_02465	COG4175	Glycine betaine
J9253_02470	COG4176	ABC-type proline glycine betaine transport system permease component
J9253_02475	COG2113	Glycine betaine
J9253_02480	COG2264	protein methyltransferase activity
J9253_02485	COG4372	Transposase
J9253_02530	COG4988	ABC transporter
J9253_02535	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
J9253_02540	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
J9253_02545	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
J9253_02570	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
J9253_02580	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
J9253_02585	COG1530	ribonuclease E activity
J9253_02595	COG0546	phosphoglycolate phosphatase activity
J9253_02600	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
J9253_02600	COG0616	signal peptide processing
J9253_02605	COG1546	Belongs to the CinA family
J9253_02610	COG3243	poly(R)-hydroxyalkanoic acid synthase
J9253_02625	COG1262	PFAM Formylglycine-generating sulfatase enzyme
J9253_02640	COG4636	protein conserved in cyanobacteria
J9253_02645	COG0675	Transposase, IS605 OrfB family
J9253_02660	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
J9253_02665	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
J9253_02675	COG2081	HI0933 family
J9253_02680	COG0842	Transport permease protein
J9253_02685	COG1131	(ABC) transporter
J9253_02750	COG4232	protein-disulfide reductase activity
J9253_02795	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
J9253_02805	COG0730	response to heat
J9253_02810	COG0675	Transposase, IS605 OrfB family
J9253_02815	COG1160	GTP binding
J9253_02820	COG2816	NAD+ diphosphatase activity
J9253_02830	COG4636	protein conserved in cyanobacteria
J9253_02840	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
J9253_02865	COG0675	Transposase, IS605 OrfB family
J9253_02870	COG5433	transposase activity
J9253_02925	COG1454	alcohol dehydrogenase
J9253_02935	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
J9253_02940	COG2976	Protein conserved in bacteria
J9253_02945	COG0124	histidyl-tRNA synthetase
J9253_02960	COG0820	rRNA (adenine-C2-)-methyltransferase activity
J9253_02965	COG0105	UTP biosynthetic process
J9253_02975	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
J9253_02985	COG4797	methyltransferase
J9253_02985	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
J9253_03000	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
J9253_03005	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
J9253_03025	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
J9253_03030	COG0424	maF-like protein
J9253_03040	COG0333	Belongs to the bacterial ribosomal protein bL32 family
J9253_03045	COG0416	fatty acid biosynthetic process
J9253_03050	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
J9253_03055	COG2954	triphosphatase activity
J9253_03060	COG0513	Belongs to the DEAD box helicase family
J9253_03065	COG3552	Protein containing von Willebrand factor type A (VWA) domain
J9253_03070	COG2425	protein containing a von Willebrand factor type A (vWA) domain
J9253_03075	COG0714	Associated with various cellular activities
J9253_03090	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
J9253_03095	COG0287	Prephenate dehydrogenase
J9253_03105	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
J9253_03110	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
J9253_03120	COG0776	regulation of translation
J9253_03125	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
J9253_03130	COG0284	orotidine-5'-phosphate decarboxylase activity
J9253_03135	COG2915	High frequency lysogenization protein hflD homolog
J9253_03140	COG0482	sulfurtransferase activity
J9253_03165	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
J9253_03175	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
J9253_03195	COG2974	May be involved in recombination
J9253_03205	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
J9253_03205	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
J9253_03225	COG1850	ribulose-bisphosphate carboxylase activity
J9253_03270	COG1850	ribulose-bisphosphate carboxylase activity
J9253_03305	COG1858	cytochrome C peroxidase
J9253_03315	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
J9253_03325	COG0675	Transposase, IS605 OrfB family
J9253_03330	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
J9253_03335	COG1605	Chorismate mutase
J9253_03335	COG0077	Prephenate dehydratase
J9253_03370	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
J9253_03375	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
J9253_03385	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
J9253_03400	COG1414	Transcriptional regulator
J9253_03415	COG1358	cellular component organization or biogenesis
J9253_03430	COG2304	oxidoreductase activity
J9253_03485	COG0583	DNA-binding transcription factor activity
J9253_03510	COG3118	belongs to the thioredoxin family
J9253_03515	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
J9253_03520	COG0443	Heat shock 70 kDa protein
J9253_03525	COG0484	heat shock protein binding
J9253_03530	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
J9253_03540	COG2391	methyltransferase activity
J9253_03545	COG3909	cytochrome
J9253_03565	COG1185	polyribonucleotide nucleotidyltransferase activity
J9253_03590	COG0372	Belongs to the citrate synthase family
J9253_03600	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
J9253_03600	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
J9253_03610	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
J9253_03615	COG1115	amino acid carrier protein
J9253_03620	COG0733	neurotransmitter:sodium symporter activity
J9253_03645	COG2204	response regulator
J9253_03650	COG3852	Histidine kinase
J9253_03655	COG1294	oxidase, subunit
J9253_03670	COG0392	lysyltransferase activity
J9253_03670	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
J9253_03680	COG3012	SEC-C Motif Domain Protein
J9253_03695	COG1073	alpha beta
J9253_03695	COG2226	methyltransferase
J9253_03700	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
J9253_03715	COG0525	valine-tRNA ligase activity
J9253_03755	COG4636	protein conserved in cyanobacteria
J9253_03770	COG3132	Protein of unknown function, DUF480
J9253_03775	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
J9253_03780	COG0492	ferredoxin-NADP+ reductase activity
J9253_03785	COG1674	ftsk spoiiie
J9253_03790	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
J9253_03795	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
J9253_03800	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
J9253_03805	COG2137	regulation of response to DNA damage stimulus
J9253_03820	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
J9253_03830	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
J9253_03835	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
J9253_03840	COG0825	malonyl-CoA metabolic process
J9253_03845	COG0037	tRNA processing
J9253_03860	COG0675	Transposase, IS605 OrfB family
J9253_03915	COG4591	ABC-type transport system involved in lipoprotein release permease component
J9253_03920	COG4591	ABC-type transport system involved in lipoprotein release permease component
J9253_03925	COG1136	(ABC) transporter
J9253_03975	COG0028	Belongs to the TPP enzyme family
J9253_03985	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
J9253_04005	COG0489	protein tyrosine kinase activity
J9253_04005	COG3206	protein involved in exopolysaccharide biosynthesis
J9253_04065	COG1091	dTDP-4-dehydrorhamnose reductase activity
J9253_04095	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
J9253_04100	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
J9253_04105	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
J9253_04120	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
J9253_04140	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
J9253_04145	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
J9253_04155	COG0326	Molecular chaperone. Has ATPase activity
J9253_04170	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
J9253_04175	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
J9253_04180	COG0291	Belongs to the bacterial ribosomal protein bL35 family
J9253_04185	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
J9253_04190	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
J9253_04195	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
J9253_04195	COG0072	phenylalanine-tRNA ligase activity
J9253_04200	COG0776	regulation of translation
J9253_04220	COG1570	exodeoxyribonuclease VII activity
J9253_04235	COG0518	GMP synthase (glutamine-hydrolyzing) activity
J9253_04235	COG0519	Catalyzes the synthesis of GMP from XMP
J9253_04255	COG1262	PFAM Formylglycine-generating sulfatase enzyme
J9253_04255	COG0515	serine threonine protein kinase
J9253_04265	COG2852	Protein conserved in bacteria
J9253_04270	COG0515	serine threonine protein kinase
J9253_04270	COG1262	PFAM Formylglycine-generating sulfatase enzyme
J9253_04275	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
J9253_04290	COG0450	alkyl hydroperoxide reductase
J9253_04310	COG0243	molybdopterin cofactor binding
J9253_04325	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
J9253_04340	COG0723	plastoquinol--plastocyanin reductase activity
J9253_04345	COG2814	Major facilitator Superfamily
J9253_04360	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
J9253_04375	COG0138	bifunctional purine biosynthesis protein purh
J9253_04380	COG1028	Short-chain dehydrogenase reductase Sdr
J9253_04385	COG0500	methyltransferase
J9253_04400	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
J9253_04420	COG0402	S-adenosylhomocysteine deaminase activity
J9253_04425	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
J9253_04440	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
J9253_04445	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
J9253_04470	COG0437	4 iron, 4 sulfur cluster binding
J9253_04475	COG0243	molybdopterin cofactor binding
J9253_04495	COG4191	Histidine kinase
J9253_04500	COG2204	response regulator
J9253_04505	COG1797	cobyrinic acid a,c-diamide synthase activity
J9253_04515	COG3850	Histidine kinase
J9253_04520	COG2197	response regulator
J9253_04525	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
J9253_04535	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
J9253_04540	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
J9253_04550	COG0179	Fumarylacetoacetate (FAA) hydrolase
J9253_04555	COG2862	Uncharacterized protein family, UPF0114
J9253_04575	COG0837	glucose binding
J9253_04585	COG0488	(ABC) transporter
J9253_04595	COG0675	Transposase, IS605 OrfB family
J9253_04600	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
J9253_04635	COG0675	Transposase, IS605 OrfB family
J9253_04665	COG1013	pyruvate-flavodoxin oxidoreductase activity
J9253_04670	COG0674	pyruvate-flavodoxin oxidoreductase activity
J9253_04685	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
J9253_04690	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
J9253_04695	COG1862	Preprotein translocase
J9253_04700	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
J9253_04705	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
J9253_04710	COG1509	lysine 2,3-aminomutase activity
J9253_04775	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
J9253_04780	COG0601	transmembrane transport
J9253_04790	COG1266	CAAX protease self-immunity
J9253_04795	COG3243	poly(R)-hydroxyalkanoic acid synthase
J9253_04805	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
J9253_04810	COG1472	Belongs to the glycosyl hydrolase 3 family
J9253_04820	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
J9253_04835	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
J9253_04855	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
J9253_04860	COG2003	Belongs to the UPF0758 family
J9253_04875	COG2814	Major facilitator Superfamily
J9253_04880	COG0513	Belongs to the DEAD box helicase family
J9253_04890	COG4636	protein conserved in cyanobacteria
J9253_04905	COG1401	restriction endodeoxyribonuclease activity
J9253_04930	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
J9253_04940	COG4106	trans-aconitate 2-methyltransferase activity
J9253_04960	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
J9253_04975	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
J9253_04990	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
J9253_04995	COG1518	maintenance of DNA repeat elements
J9253_05045	COG2205	protein histidine kinase activity
J9253_05050	COG0745	RESPONSE REGULATOR receiver
J9253_05060	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
J9253_05065	COG1061	Type III restriction enzyme res subunit
J9253_05070	COG1061	Type III restriction enzyme res subunit
J9253_05085	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
J9253_05110	COG3040	lipid binding
J9253_05130	COG1028	Short-chain dehydrogenase reductase Sdr
J9253_05140	COG1366	Belongs to the anti-sigma-factor antagonist family
J9253_05140	COG2202	Pas domain
J9253_05160	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
J9253_05180	COG3177	Filamentation induced by cAMP protein fic
J9253_05215	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
J9253_05240	COG2766	serine protein kinase
J9253_05245	COG2718	Belongs to the UPF0229 family
J9253_05250	COG2719	SpoVR family
J9253_05255	COG4566	intracellular signal transduction
J9253_05285	COG2183	response to ionizing radiation
J9253_05290	COG0495	leucyl-tRNA aminoacylation
J9253_05300	COG2084	Dehydrogenase
J9253_05305	COG0116	Belongs to the methyltransferase superfamily
J9253_05305	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
J9253_05325	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
J9253_05335	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
J9253_05345	COG0300	oxidoreductase activity
J9253_05365	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
J9253_05370	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
J9253_05380	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
J9253_05385	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
J9253_05400	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
J9253_05405	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
J9253_05410	COG0542	response to heat
J9253_05415	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
J9253_05455	COG0714	Associated with various cellular activities
J9253_05490	COG1518	maintenance of DNA repeat elements
J9253_05555	COG0277	FAD linked oxidase domain protein
J9253_05565	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
J9253_05575	COG2824	Alkylphosphonate utilization operon protein PhnA
J9253_05595	COG3954	Phosphoribulokinase
J9253_05610	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
J9253_05625	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
J9253_05635	COG1959	2 iron, 2 sulfur cluster binding
J9253_05640	COG0489	protein tyrosine kinase activity
J9253_05650	COG0717	Belongs to the dCTP deaminase family
J9253_05660	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
J9253_05665	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
J9253_05670	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
J9253_05680	COG0330	HflC and HflK could
J9253_05685	COG0330	HflC and HflK could
J9253_05700	COG0343	queuine tRNA-ribosyltransferase activity
J9253_05720	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
J9253_05725	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
J9253_05730	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
J9253_05735	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
J9253_05745	COG0180	Tryptophanyl-tRNA synthetase
J9253_05750	COG1994	Peptidase M50
J9253_05755	COG0009	L-threonylcarbamoyladenylate synthase
J9253_05760	COG2917	probably involved in intracellular septation
J9253_05765	COG2350	Protein conserved in bacteria
J9253_05770	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
J9253_05780	COG0438	transferase activity, transferring glycosyl groups
J9253_05790	COG0438	transferase activity, transferring glycosyl groups
J9253_06115	COG3617	BRO family, N-terminal domain
J9253_06145	COG0358	DNA primase activity
J9253_06150	COG0067	glutamate synthase
J9253_06150	COG0069	glutamate synthase activity
J9253_06150	COG0070	glutamate synthase
J9253_06155	COG0493	'glutamate synthase
J9253_06160	COG3150	esterase
J9253_06175	COG0438	transferase activity, transferring glycosyl groups
J9253_06200	COG0436	Aminotransferase
J9253_06235	COG2321	neutral zinc metallopeptidase
J9253_06240	COG0436	Aminotransferase
J9253_06245	COG0739	heme binding
J9253_06255	COG3853	Toxic anion resistance protein (TelA)
J9253_06280	COG2920	part of a sulfur-relay system
J9253_06285	COG0791	NLP P60 protein
J9253_06305	COG0415	Belongs to the DNA photolyase family
J9253_06310	COG0675	Transposase, IS605 OrfB family
J9253_06315	COG0675	Transposase, IS605 OrfB family
J9253_06320	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
J9253_06325	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
J9253_06330	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
J9253_06335	COG0134	indole-3-glycerol-phosphate synthase activity
J9253_06340	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
J9253_06355	COG1609	Transcriptional regulator
J9253_06355	COG2207	Transcriptional regulator
J9253_06365	COG0246	Mannitol dehydrogenase
J9253_06370	COG3842	ATPase activity
J9253_06380	COG1175	transmembrane transport
J9253_06390	COG1070	Carbohydrate kinase
J9253_06400	COG0800	Aldolase
J9253_06405	COG0129	dihydroxy-acid dehydratase activity
J9253_06410	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
J9253_06430	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
J9253_06450	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
J9253_06455	COG4657	Part of a membrane complex involved in electron transport
J9253_06460	COG2878	Part of a membrane complex involved in electron transport
J9253_06465	COG4656	Part of a membrane complex involved in electron transport
J9253_06470	COG4658	electron transport chain
J9253_06475	COG4659	FMN binding
J9253_06480	COG4660	Part of a membrane complex involved in electron transport
J9253_06485	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
J9253_06520	COG0730	response to heat
J9253_06525	COG1074	ATP-dependent DNA helicase activity
J9253_06560	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
J9253_06565	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
J9253_06580	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
J9253_06580	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
J9253_06585	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
J9253_06590	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
J9253_06625	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
J9253_06630	COG1350	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
J9253_06660	COG0714	Associated with various cellular activities
J9253_06665	COG0271	Belongs to the BolA IbaG family
J9253_06675	COG0688	phosphatidylethanolamine metabolic process
J9253_06680	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
J9253_06690	COG0675	Transposase, IS605 OrfB family
J9253_06705	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
J9253_06710	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
J9253_06725	COG1132	(ABC) transporter
J9253_06755	COG0500	methyltransferase
J9253_06820	COG2264	protein methyltransferase activity
J9253_06825	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
J9253_06830	COG0508	dehydrogenase complex catalyzes the overall conversion of
J9253_06840	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
J9253_06845	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
J9253_06850	COG1177	transmembrane transport
J9253_06865	COG1176	ABC-type spermidine putrescine transport system, permease component I
J9253_06870	COG3842	ATPase activity
J9253_06890	COG0446	pyridine nucleotide-disulphide oxidoreductase
J9253_06895	COG4890	Cyd operon protein YbgT
J9253_06900	COG1294	oxidase, subunit
J9253_06910	COG0446	pyridine nucleotide-disulphide oxidoreductase
J9253_06915	COG0442	prolyl-tRNA aminoacylation
J9253_06920	COG1420	regulation of RNA biosynthetic process
J9253_06925	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
J9253_06930	COG0497	DNA recombination
J9253_06945	COG0386	Belongs to the glutathione peroxidase family
J9253_06950	COG2957	Belongs to the agmatine deiminase family
J9253_06955	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
J9253_06965	COG0436	Aminotransferase
J9253_07005	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
J9253_07025	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
J9253_07055	COG0716	FMN binding
J9253_07100	COG4231	catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates
J9253_07125	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
J9253_07135	COG4804	nuclease activity
J9253_07195	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
J9253_07210	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
J9253_07265	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
J9253_07305	COG0439	Biotin carboxylase
J9253_07360	COG3411	Ferredoxin
J9253_07365	COG2914	Belongs to the UPF0125 (RnfH) family
J9253_07380	COG4658	electron transport chain
J9253_07385	COG4656	Part of a membrane complex involved in electron transport
J9253_07390	COG2878	Part of a membrane complex involved in electron transport
J9253_07395	COG4657	Part of a membrane complex involved in electron transport
J9253_07425	COG0426	domain, Protein
J9253_07430	COG0633	Ferredoxin
J9253_07450	COG1959	2 iron, 2 sulfur cluster binding
J9253_07480	COG4636	protein conserved in cyanobacteria
J9253_07485	COG0488	(ABC) transporter
J9253_07490	COG4680	protein conserved in bacteria
J9253_07495	COG5499	transcription regulator containing HTH domain
J9253_07575	COG2337	Toxic component of a toxin-antitoxin (TA) module
J9253_07590	COG0582	viral genome integration into host DNA
J9253_07605	COG3657	addiction module killer protein
J9253_07630	COG4680	protein conserved in bacteria
J9253_07635	COG5499	transcription regulator containing HTH domain
J9253_07660	COG2814	Major facilitator Superfamily
J9253_07665	COG1271	oxidase subunit
J9253_07715	COG4636	protein conserved in cyanobacteria
J9253_07720	COG4974	Belongs to the 'phage' integrase family
J9253_07725	COG0517	IMP dehydrogenase activity
J9253_07785	COG0720	synthase
J9253_07790	COG0602	queuosine metabolic process
J9253_07795	COG1643	Atp-dependent helicase
J9253_07830	COG1064	alcohol dehydrogenase
J9253_07865	COG2951	lytic endotransglycosylase activity
J9253_07890	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
J9253_07895	COG4181	ATPase activity
J9253_07910	COG0651	ATP synthesis coupled electron transport
J9253_07915	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
J9253_07915	COG2111	Na H antiporter
J9253_07920	COG0651	ATP synthesis coupled electron transport
J9253_07935	COG1320	monovalent cation:proton antiporter activity
J9253_07960	COG1320	monovalent cation:proton antiporter activity
J9253_07965	COG2212	antiporter activity
J9253_07970	COG1863	multisubunit Na H antiporter MnhE subunit
J9253_07975	COG0651	ATP synthesis coupled electron transport
J9253_07980	COG1006	Multisubunit Na H antiporter MnhC subunit
J9253_07985	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
J9253_07985	COG2111	Na H antiporter
J9253_07995	COG4249	Peptidase C14 caspase catalytic subunit p20
J9253_07995	COG2319	Wd-40 repeat
J9253_08000	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
J9253_08005	COG0567	Dehydrogenase, E1 component
J9253_08025	COG1053	succinate dehydrogenase
J9253_08035	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
J9253_08040	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
J9253_08055	COG0675	Transposase, IS605 OrfB family
J9253_08065	COG2885	chlorophyll binding
J9253_08070	COG0261	This protein binds to 23S rRNA in the presence of protein L20
J9253_08070	COG3743	rRNA binding
J9253_08085	COG0322	excinuclease ABC activity
J9253_08095	COG0574	Belongs to the PEP-utilizing enzyme family
J9253_08095	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
J9253_08105	COG1070	Carbohydrate kinase
J9253_08110	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
J9253_08115	COG0857	belongs to the CobB CobQ family
J9253_08115	COG0280	phosphate acetyltransferase
J9253_08175	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
J9253_08185	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
J9253_08195	COG0215	cysteine-tRNA ligase activity
J9253_08230	COG4456	Virulence-associated protein
J9253_08235	COG0459	protein refolding
J9253_08240	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
J9253_08250	COG5002	protein histidine kinase activity
J9253_08250	COG5001	Diguanylate cyclase
J9253_08260	COG4232	protein-disulfide reductase activity
J9253_08275	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
J9253_08280	COG0628	permease
J9253_08290	COG2885	chlorophyll binding
J9253_08295	COG0564	pseudouridine synthase activity
J9253_08315	COG0557	exoribonuclease II activity
J9253_08320	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
J9253_08335	COG1322	Protein conserved in bacteria
J9253_08350	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
J9253_08360	COG0850	regulation of cytokinetic process
J9253_08370	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
J9253_08390	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
J9253_08420	COG0308	aminopeptidase N
J9253_08470	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
J9253_08475	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
J9253_08480	COG1210	Utp--glucose-1-phosphate uridylyltransferase
J9253_08500	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
J9253_08525	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
J9253_08535	COG0579	oxidoreductase
J9253_08560	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
J9253_08565	COG2835	tetraacyldisaccharide 4'-kinase activity
J9253_08570	COG1663	tetraacyldisaccharide 4'-kinase activity
J9253_08575	COG1132	(ABC) transporter
J9253_08580	COG0848	biopolymer transport protein
J9253_08585	COG0811	peptide transport
J9253_08595	COG0741	lytic transglycosylase activity
J9253_08600	COG4717	serine-type aminopeptidase activity
J9253_08605	COG0420	3'-5' exonuclease activity
J9253_08610	COG2171	N-acyltransferase activity
J9253_08615	COG0436	Aminotransferase
J9253_08640	COG1902	pentaerythritol trinitrate reductase activity
J9253_08650	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
J9253_08680	COG1309	transcriptional regulator
J9253_08685	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
J9253_08695	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
J9253_08710	COG0456	acetyltransferase
J9253_08715	COG1573	uracil-dna glycosylase
J9253_08720	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
J9253_08730	COG2268	Band 7 protein
J9253_08740	COG1183	phosphatidylcholine synthase activity
J9253_08745	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
J9253_08760	COG0367	asparagine synthase
J9253_08765	COG0583	DNA-binding transcription factor activity
J9253_08775	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
J9253_08780	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
J9253_08790	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
J9253_08800	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
J9253_08800	COG0517	IMP dehydrogenase activity
J9253_08805	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
J9253_08815	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
J9253_08820	COG1137	ATPase activity
J9253_08835	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
J9253_08840	COG1660	Displays ATPase and GTPase activities
J9253_08845	COG0745	RESPONSE REGULATOR receiver
J9253_08850	COG0438	transferase activity, transferring glycosyl groups
J9253_08880	COG0469	pyruvate kinase activity
J9253_08880	COG0469	pyruvate kinase activity
J9253_08885	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
J9253_08890	COG2226	methyltransferase
J9253_08890	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
J9253_08890	COG0596	Alpha beta hydrolase
J9253_08905	COG0573	inorganic phosphate transmembrane transporter activity
J9253_08915	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
J9253_08935	COG0306	phosphate transporter
J9253_08940	COG1392	Phosphate transport regulator
J9253_08945	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
J9253_09040	COG2308	Evidence 4 Homologs of previously reported genes of
J9253_09045	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
J9253_09050	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
J9253_09060	COG2951	lytic endotransglycosylase activity
J9253_09070	COG1473	amidohydrolase
J9253_09095	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
J9253_09110	COG0267	Belongs to the bacterial ribosomal protein bL33 family
J9253_09115	COG0227	Belongs to the bacterial ribosomal protein bL28 family
J9253_09120	COG1801	Protein of unknown function DUF72
J9253_09125	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
J9253_09145	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
J9253_09155	COG2957	Belongs to the agmatine deiminase family
J9253_09165	COG2270	Major facilitator Superfamily
J9253_09180	COG1346	cytolysis
J9253_09205	COG4804	nuclease activity
J9253_09245	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
J9253_09265	COG1487	ribonuclease activity
J9253_09295	COG0668	transmembrane transport
J9253_09320	COG0745	RESPONSE REGULATOR receiver
J9253_09325	COG2205	protein histidine kinase activity
J9253_09340	COG0305	Participates in initiation and elongation during chromosome replication
J9253_09345	COG0359	binds to the 23S rRNA
J9253_09350	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
J9253_09355	COG0360	Binds together with S18 to 16S ribosomal RNA
J9253_09360	COG0515	serine threonine protein kinase
J9253_09360	COG2815	serine threonine protein kinase
J9253_09400	COG0741	lytic transglycosylase activity
J9253_09405	COG2833	Protein of unknown function (DUF455)
J9253_09410	COG2379	hydroxypyruvate reductase
J9253_09450	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
J9253_09455	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
J9253_09465	COG1215	transferase activity, transferring glycosyl groups
J9253_09470	COG3250	beta-galactosidase activity
J9253_09485	COG2208	phosphoserine phosphatase activity
J9253_09500	COG5002	protein histidine kinase activity
J9253_09500	COG2205	protein histidine kinase activity
J9253_09500	COG0784	Response regulator, receiver
J9253_09530	COG0232	Belongs to the dGTPase family. Type 2 subfamily
J9253_09535	COG1295	ribonuclease BN
J9253_09550	COG2205	protein histidine kinase activity
J9253_09555	COG0745	RESPONSE REGULATOR receiver
J9253_09595	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
J9253_09615	COG0356	it plays a direct role in the translocation of protons across the membrane
J9253_09625	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
J9253_09630	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
J9253_09635	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
J9253_09650	COG0582	viral genome integration into host DNA
J9253_09660	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
J9253_09665	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
J9253_09670	COG3123	guanosine phosphorylase activity
J9253_09675	COG0312	modulator of DNA gyrase
J9253_09680	COG0312	modulator of DNA gyrase
J9253_09700	COG0424	maF-like protein
J9253_09705	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
J9253_09715	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
J9253_09735	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
J9253_09735	COG1648	precorrin-2 dehydrogenase activity
J9253_09745	COG1393	Belongs to the ArsC family
J9253_09750	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
J9253_09760	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
J9253_09765	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
J9253_09770	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
J9253_09795	COG0433	COG0433 Predicted ATPase
J9253_09805	COG0511	ligase activity, forming carbon-carbon bonds
J9253_09810	COG0439	Biotin carboxylase
J9253_09815	COG2264	protein methyltransferase activity
J9253_09825	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
J9253_09830	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
J9253_09845	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
J9253_09860	COG1393	Belongs to the ArsC family
J9253_09865	COG0675	Transposase, IS605 OrfB family
J9253_09875	COG0675	Transposase, IS605 OrfB family
J9253_09910	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
J9253_09915	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
J9253_09935	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
J9253_09950	COG4249	Peptidase C14 caspase catalytic subunit p20
J9253_09950	COG2319	Wd-40 repeat
J9253_09995	COG4942	peptidase
J9253_10005	COG2205	protein histidine kinase activity
J9253_10005	COG0784	Response regulator, receiver
J9253_10005	COG2198	Histidine kinase
J9253_10010	COG0736	holo-[acyl-carrier-protein] synthase activity
J9253_10015	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
J9253_10020	COG1381	Involved in DNA repair and RecF pathway recombination
J9253_10030	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
J9253_10050	COG0481	GTPase activity
J9253_10060	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
J9253_10090	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
J9253_10095	COG2850	peptidyl-arginine hydroxylation
J9253_10115	COG4953	penicillin-binding protein 1C
J9253_10120	COG2373	Large extracellular alpha-helical protein
J9253_10145	COG0516	GMP reductase activity
J9253_10145	COG0517	IMP dehydrogenase activity
J9253_10150	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
J9253_10155	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
J9253_10160	COG3118	belongs to the thioredoxin family
J9253_10175	COG1566	PFAM secretion protein HlyD family protein
J9253_10190	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
J9253_10210	COG0406	alpha-ribazole phosphatase activity
J9253_10215	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
J9253_10225	COG0505	Belongs to the CarA family
J9253_10230	COG0489	protein tyrosine kinase activity
J9253_10235	COG0587	DNA-directed DNA polymerase activity
J9253_10250	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
J9253_10260	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
J9253_10270	COG3588	fructose-bisphosphate aldolase
J9253_10275	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
J9253_10280	COG2326	polyphosphate kinase activity
J9253_10310	COG0789	Transcriptional regulator
J9253_10320	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
J9253_10345	COG1136	(ABC) transporter
J9253_10385	COG3237	CsbD-like
J9253_10395	COG3459	Glycosyltransferase 36 associated
J9253_10400	COG0628	permease
J9253_10450	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
J9253_10455	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
J9253_10460	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
J9253_10475	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
J9253_10485	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
J9253_10490	COG0575	Belongs to the CDS family
J9253_10495	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
J9253_10500	COG0233	cytoplasmic translational termination
J9253_10515	COG0675	Transposase, IS605 OrfB family
J9253_10525	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
J9253_10530	COG0052	Belongs to the universal ribosomal protein uS2 family
J9253_10535	COG0024	Methionine aminopeptidase
J9253_10545	COG1196	nuclear chromosome segregation
J9253_10550	COG3115	cell septum assembly
J9253_10570	COG1126	abc transporter atp-binding protein
J9253_10575	COG0765	amino acid transport
J9253_10580	COG4597	amino acid ABC transporter
J9253_10585	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
J9253_10590	COG0815	Transfers the fatty acyl group on membrane lipoproteins
J9253_10595	COG4535	Mg2 and Co2 transporter CorC
J9253_10605	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
J9253_10610	COG1702	phosphate starvation-inducible protein PhoH
J9253_10620	COG2205	protein histidine kinase activity
J9253_10620	COG0784	Response regulator, receiver
J9253_10620	COG5002	protein histidine kinase activity
J9253_10625	COG0812	UDP-N-acetylmuramate dehydrogenase activity
J9253_10630	COG2010	Cytochrome c
J9253_10645	COG3278	Belongs to the heme-copper respiratory oxidase family
J9253_10650	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
J9253_10660	COG0653	protein targeting
J9253_10665	COG0697	spore germination
J9253_10685	COG0675	Transposase, IS605 OrfB family
J9253_10725	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
J9253_10725	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
J9253_10730	COG0509	glycine decarboxylation via glycine cleavage system
J9253_10735	COG0404	The glycine cleavage system catalyzes the degradation of glycine
J9253_10740	COG1863	multisubunit Na H antiporter MnhE subunit
J9253_10760	COG2111	Na H antiporter
J9253_10765	COG1006	Multisubunit Na H antiporter MnhC subunit
J9253_10770	COG0651	ATP synthesis coupled electron transport
J9253_10775	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
J9253_10780	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
J9253_10785	COG0649	NAD binding
J9253_10785	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
J9253_10790	COG0649	NAD binding
J9253_10805	COG4124	Belongs to the glycosyl hydrolase 26 family
J9253_10805	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
J9253_10840	COG1309	transcriptional regulator
J9253_10845	COG0604	alcohol dehydrogenase
J9253_10870	COG0676	glucose-6-phosphate 1-epimerase activity
J9253_10875	COG2217	Heavy metal translocating P-type atpase
J9253_10915	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
J9253_10925	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
J9253_10930	COG1555	photosystem II stabilization
J9253_10940	COG0754	glutathionylspermidine amidase activity
J9253_10945	COG1858	cytochrome C peroxidase
J9253_10950	COG0577	efflux transmembrane transporter activity
J9253_10950	COG1136	(ABC) transporter
J9253_10955	COG0577	efflux transmembrane transporter activity
J9253_10955	COG1136	(ABC) transporter
J9253_10995	COG0745	RESPONSE REGULATOR receiver
J9253_11000	COG2205	protein histidine kinase activity
J9253_11010	COG2885	chlorophyll binding
J9253_11015	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
J9253_11025	COG2193	ferroxidase activity
J9253_11035	COG1858	cytochrome C peroxidase
J9253_11080	COG1840	ABC-type Fe3 transport system, periplasmic component
J9253_11085	COG1178	ABC-type Fe3 transport system permease component
J9253_11090	COG3842	ATPase activity
J9253_11100	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
J9253_11110	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
J9253_11115	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
J9253_11120	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
J9253_11125	COG2251	uridine kinase activity
J9253_11125	COG0195	Participates in both transcription termination and antitermination
J9253_11130	COG0779	Required for maturation of 30S ribosomal subunits
J9253_11145	COG1007	ATP synthesis coupled electron transport
J9253_11160	COG0713	ATP synthesis coupled electron transport
J9253_11170	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
J9253_11180	COG1034	ATP synthesis coupled electron transport
J9253_11195	COG0649	NAD binding
J9253_11200	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
J9253_11205	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
J9253_11210	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
J9253_11225	COG0149	triose-phosphate isomerase activity
J9253_11230	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
J9253_11235	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
J9253_11240	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
J9253_11245	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
J9253_11280	COG0493	'glutamate synthase
J9253_11295	COG2920	part of a sulfur-relay system
J9253_11300	COG2168	tRNA wobble position uridine thiolation
J9253_11305	COG2923	Belongs to the DsrF TusC family
J9253_11310	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
J9253_11315	COG2221	Nitrite and sulphite reductase 4Fe-4S
J9253_11320	COG2221	Nitrite and sulphite reductase 4Fe-4S
J9253_11355	COG3128	pkhd-type hydroxylase
J9253_11385	COG0730	response to heat
J9253_11390	COG4636	protein conserved in cyanobacteria
J9253_11410	COG0432	Pfam Uncharacterised protein family UPF0047
J9253_11415	COG0778	Nitroreductase
J9253_11430	COG1199	ATP-dependent helicase activity
J9253_11440	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
J9253_11460	COG2914	Belongs to the UPF0125 (RnfH) family
J9253_11470	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
J9253_11475	COG0735	belongs to the Fur family
J9253_11480	COG0828	Belongs to the bacterial ribosomal protein bS21 family
J9253_11485	COG1610	YqeY-like protein
J9253_11505	COG1376	ErfK ybiS ycfS ynhG family protein
J9253_11515	COG1286	toxin biosynthetic process
J9253_11525	COG0285	dihydrofolate synthase activity
J9253_11535	COG0159	tryptophan synthase activity
J9253_11540	COG0133	tryptophan synthase activity
J9253_11565	COG0675	Transposase, IS605 OrfB family
J9253_11570	COG1196	nuclear chromosome segregation
J9253_11570	COG0741	lytic transglycosylase activity
J9253_11570	COG0739	heme binding
J9253_11590	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
J9253_11645	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
J9253_11655	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
J9253_11675	COG3237	CsbD-like
J9253_11685	COG0069	glutamate synthase activity
J9253_11700	COG0675	Transposase, IS605 OrfB family
J9253_11705	COG0675	Transposase, IS605 OrfB family
J9253_11715	COG0006	proline dipeptidase activity
J9253_11720	COG3079	Belongs to the UPF0149 family
J9253_11755	COG0494	nUDIX hydrolase
J9253_11760	COG0583	DNA-binding transcription factor activity
J9253_11765	COG2814	Major facilitator Superfamily
J9253_11820	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
J9253_11830	COG0101	tRNA pseudouridine synthase activity
J9253_11850	COG0066	3-isopropylmalate dehydratase activity
J9253_11860	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
J9253_11905	COG0537	adenosine 5'-monophosphoramidase activity
J9253_11910	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
J9253_11915	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
J9253_11930	COG0745	RESPONSE REGULATOR receiver
J9253_11945	COG0840	transmembrane signaling receptor activity
J9253_11950	COG2198	Histidine kinase
J9253_11950	COG0784	Response regulator, receiver
J9253_11950	COG0643	Histidine kinase
J9253_11955	COG0745	RESPONSE REGULATOR receiver
J9253_11985	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
J9253_11990	COG1196	nuclear chromosome segregation
J9253_11990	COG0741	lytic transglycosylase activity
J9253_11990	COG0739	heme binding
J9253_12005	COG0443	Heat shock 70 kDa protein
J9253_12010	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
J9253_12015	COG0316	Belongs to the HesB IscA family
J9253_12020	COG0822	iron-sulfur transferase activity
J9253_12025	COG1104	cysteine desulfurase activity
J9253_12030	COG1959	2 iron, 2 sulfur cluster binding
J9253_12105	COG0328	RNA-DNA hybrid ribonuclease activity
J9253_12115	COG1388	LysM domain
J9253_12115	COG0741	lytic transglycosylase activity
J9253_12125	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
J9253_12140	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
J9253_12160	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
J9253_12165	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
J9253_12185	COG0776	regulation of translation
J9253_12190	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
J9253_12195	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
J9253_12200	COG0740	serine-type endopeptidase activity
J9253_12205	COG0544	peptidyl-prolyl cis-trans isomerase activity
J9253_12230	COG1116	anion transmembrane transporter activity
J9253_12240	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
J9253_12245	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
J9253_12245	COG1116	anion transmembrane transporter activity
J9253_12250	COG2223	nitrite transmembrane transporter activity
J9253_12255	COG0515	serine threonine protein kinase
J9253_12255	COG2815	serine threonine protein kinase
J9253_12260	COG1116	anion transmembrane transporter activity
J9253_12260	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
J9253_12280	COG3655	Transcriptional regulator
J9253_12285	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
J9253_12290	COG5433	transposase activity
J9253_12315	COG1595	DNA-templated transcription, initiation
J9253_12325	COG0681	Belongs to the peptidase S26 family
J9253_12335	COG0583	DNA-binding transcription factor activity
J9253_12370	COG1309	transcriptional regulator
J9253_12385	COG0625	glutathione transferase activity
J9253_12390	COG0243	molybdopterin cofactor binding
J9253_12395	COG2146	nitrite reductase [NAD(P)H] activity
J9253_12400	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
J9253_12430	COG1238	metal cluster binding
J9253_12435	COG3243	poly(R)-hydroxyalkanoic acid synthase
J9253_12445	COG0183	Belongs to the thiolase family
J9253_12450	COG1028	Short-chain dehydrogenase reductase Sdr
J9253_12455	COG5394	Polyhydroxyalkanoate synthesis repressor PhaR
J9253_12530	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
J9253_12535	COG1518	maintenance of DNA repeat elements
J9253_12545	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
J9253_12580	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
J9253_12585	COG0316	Belongs to the HesB IscA family
J9253_12600	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
J9253_12610	COG1981	membrane
J9253_12615	COG0494	nUDIX hydrolase
J9253_12625	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
J9253_12635	COG0463	Glycosyl transferase, family 2
J9253_12640	COG0457	Tetratricopeptide repeat
J9253_12640	COG0463	Glycosyl transferase, family 2
J9253_12645	COG0859	PFAM glycosyl transferase family 9
J9253_12655	COG0438	transferase activity, transferring glycosyl groups
J9253_12665	COG0438	transferase activity, transferring glycosyl groups
J9253_12665	COG1216	Glycosyl transferase, family 2
J9253_12690	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
J9253_12715	COG0488	(ABC) transporter
J9253_12725	COG0583	DNA-binding transcription factor activity
J9253_12735	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
J9253_12740	COG3156	type II secretion system protein K
J9253_12750	COG2165	general secretion pathway protein
J9253_12755	COG4970	Tfp pilus assembly protein FimT
J9253_12765	COG1459	type II secretion system
J9253_12770	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
J9253_12780	COG2304	oxidoreductase activity
J9253_12820	COG0804	urea catabolic process
J9253_12825	COG0832	Belongs to the urease beta subunit family
J9253_12830	COG0831	urea catabolic process
J9253_12835	COG0829	nickel cation binding
J9253_12850	COG2233	PERMEase
J9253_12860	COG1079	Belongs to the binding-protein-dependent transport system permease family
J9253_12865	COG4603	Belongs to the binding-protein-dependent transport system permease family
J9253_12870	COG3845	ABC transporter
J9253_12880	COG1529	Aldehyde oxidase and xanthine dehydrogenase
J9253_12890	COG0402	S-adenosylhomocysteine deaminase activity
J9253_12895	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
J9253_12900	COG4266	Belongs to the allantoicase family
J9253_12925	COG2351	hydroxyisourate hydrolase activity
J9253_12930	COG1309	transcriptional regulator
J9253_12945	COG1129	ABC transporter
J9253_12975	COG1215	transferase activity, transferring glycosyl groups
J9253_12980	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
J9253_13010	COG1450	Type ii and iii secretion system protein
J9253_13045	COG0675	Transposase, IS605 OrfB family
J9253_13075	COG0489	protein tyrosine kinase activity
J9253_13075	COG3206	protein involved in exopolysaccharide biosynthesis
J9253_13135	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
J9253_13155	COG1561	YicC-like family, N-terminal region
J9253_13165	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
J9253_13170	COG0218	Necessary for normal cell division and for the maintenance of normal septation
J9253_13180	COG1333	cytochrome c biogenesis protein
J9253_13185	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
J9253_13190	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
J9253_13195	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
J9253_13200	COG0321	lipoyl(octanoyl) transferase activity
J9253_13205	COG2921	Belongs to the UPF0250 family
J9253_13210	COG1686	Belongs to the peptidase S11 family
J9253_13220	COG2951	lytic endotransglycosylase activity
J9253_13225	COG0772	Belongs to the SEDS family
J9253_13230	COG0768	penicillin binding
J9253_13235	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
J9253_13245	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
J9253_13250	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
J9253_13255	COG3107	peptidoglycan biosynthetic process
J9253_13260	COG0792	nuclease activity
J9253_13265	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
J9253_13270	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
J9253_13270	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
J9253_13300	COG0457	Tetratricopeptide repeat
J9253_13300	COG0463	Glycosyl transferase, family 2
J9253_13305	COG0457	Tetratricopeptide repeat
J9253_13305	COG0463	Glycosyl transferase, family 2
J9253_13330	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
J9253_13360	COG3550	peptidyl-serine autophosphorylation
J9253_13370	COG0789	Transcriptional regulator
J9253_13380	COG1024	Enoyl-CoA hydratase
J9253_13380	COG1250	3-hydroxyacyl-CoA dehydrogenase
J9253_13385	COG0318	PFAM AMP-dependent synthetase and ligase
J9253_13410	COG0037	tRNA processing
J9253_13415	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
J9253_13430	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
J9253_13435	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
J9253_13440	COG1469	GTP cyclohydrolase I activity
J9253_13455	COG1077	Cell shape determining protein MreB Mrl
J9253_13460	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
J9253_13470	COG0596	Alpha beta hydrolase
J9253_13490	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
J9253_13495	COG0154	amidase activity
J9253_13510	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
J9253_13525	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
J9253_13530	COG4215	(ABC) transporter
J9253_13590	COG0675	Transposase, IS605 OrfB family
J9253_13600	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
J9253_13605	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
J9253_13615	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
J9253_13615	COG1149	4fe-4S ferredoxin, iron-sulfur binding domain protein
J9253_13635	COG0243	molybdopterin cofactor binding
J9253_13635	COG3383	formate dehydrogenase (NAD+) activity
J9253_13640	COG0437	4 iron, 4 sulfur cluster binding
J9253_13660	COG2204	response regulator
J9253_13670	COG4662	Binding-protein-dependent transport system inner membrane component
J9253_13675	COG3842	ATPase activity
J9253_13680	COG0303	'Molybdopterin
J9253_13690	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
J9253_13695	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
J9253_13730	COG1131	(ABC) transporter
J9253_13735	COG1116	anion transmembrane transporter activity
J9253_13740	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
J9253_13745	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
J9253_13795	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
J9253_13810	COG4305	rare lipoprotein A
J9253_13865	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
J9253_13870	COG5265	(ABC) transporter
J9253_13890	COG2204	response regulator
J9253_13895	COG1940	carbohydrate kinase activity
J9253_13905	COG0564	pseudouridine synthase activity
J9253_13910	COG3273	potassium ion transport
J9253_13910	COG0471	metal ion transport
J9253_13915	COG0517	IMP dehydrogenase activity
J9253_13920	COG1944	ATP diphosphatase activity
J9253_13945	COG3738	Protein conserved in bacteria
J9253_13960	COG3028	Belongs to the UPF0307 family
J9253_13965	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
J9253_13970	COG0194	GDP metabolic process
J9253_13980	COG1187	pseudouridine synthase activity
J9253_13995	COG1262	PFAM Formylglycine-generating sulfatase enzyme
J9253_14000	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
J9253_14025	COG1643	Atp-dependent helicase
J9253_14040	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
J9253_14045	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
J9253_14050	COG1216	Glycosyl transferase, family 2
J9253_14080	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
J9253_14085	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
J9253_14090	COG2255	four-way junction helicase activity
J9253_14095	COG0824	Thioesterase
J9253_14100	COG0811	peptide transport
J9253_14120	COG2885	chlorophyll binding
J9253_14140	COG2391	methyltransferase activity
J9253_14170	COG2226	methyltransferase
J9253_14175	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
J9253_14195	COG0671	phosphoesterase, PA-phosphatase related
J9253_14215	COG0675	Transposase, IS605 OrfB family
J9253_14230	COG3100	YcgL domain-containing protein
J9253_14240	COG1166	arginine decarboxylase activity
J9253_14245	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
J9253_14250	COG2210	Belongs to the sulfur carrier protein TusA family
J9253_14260	COG1408	metallophosphoesterase
J9253_14280	COG0840	transmembrane signaling receptor activity
J9253_14290	COG0643	Histidine kinase
J9253_14290	COG0784	Response regulator, receiver
J9253_14290	COG2198	Histidine kinase
J9253_14305	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
J9253_14325	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
J9253_14335	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
J9253_14345	COG3047	cAMP biosynthetic process
J9253_14345	COG2885	chlorophyll binding
J9253_14355	COG3956	TIGRFAM MazG family protein
J9253_14360	COG0632	four-way junction helicase activity
J9253_14365	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
J9253_14395	COG1253	flavin adenine dinucleotide binding
J9253_14400	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
J9253_14405	COG0179	Fumarylacetoacetate (FAA) hydrolase
J9253_14410	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
J9253_14445	COG0488	(ABC) transporter
J9253_14455	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
J9253_14460	COG1999	signal sequence binding
J9253_14470	COG1678	Uncharacterized ACR, COG1678
J9253_14475	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
J9253_14480	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
J9253_14490	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
J9253_14500	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
J9253_14520	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
J9253_14540	COG4206	TonB-dependent receptor
J9253_14550	COG0084	hydrolase, TatD family'
J9253_14580	COG0840	transmembrane signaling receptor activity
J9253_14630	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
J9253_14635	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
J9253_14645	COG0254	rRNA binding
J9253_14650	COG4783	chaperone-mediated protein folding
J9253_14660	COG0281	malic enzyme
J9253_14735	COG1196	nuclear chromosome segregation
J9253_14735	COG0741	lytic transglycosylase activity
J9253_14735	COG0739	heme binding
J9253_14740	COG2967	ApaG domain
J9253_14745	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
J9253_14750	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
J9253_14765	COG0211	Belongs to the bacterial ribosomal protein bL27 family
J9253_14770	COG0261	This protein binds to 23S rRNA in the presence of protein L20
J9253_14775	COG0142	geranyltranstransferase activity
J9253_14800	COG0791	NLP P60 protein
J9253_14805	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
J9253_14810	COG1765	OsmC-like protein
J9253_14820	COG0189	ligase activity
J9253_14825	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
J9253_14830	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
J9253_14840	COG1054	Belongs to the UPF0176 family
J9253_14850	COG4942	peptidase
J9253_14855	COG0793	Belongs to the peptidase S41A family
J9253_14860	COG0315	cyclic pyranopterin monophosphate synthase activity
J9253_14870	COG0314	molybdopterin synthase activity
J9253_14875	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
J9253_14885	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
J9253_14890	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
J9253_14895	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
J9253_14900	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
J9253_14915	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
J9253_14945	COG3220	belongs to the UPF0276 family
J9253_14970	COG5002	protein histidine kinase activity
J9253_14975	COG0745	RESPONSE REGULATOR receiver
J9253_14980	COG2176	DNA-directed DNA polymerase activity
J9253_14980	COG5002	protein histidine kinase activity
J9253_14985	COG1758	RNA polymerase activity
J9253_14990	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
J9253_15020	COG0675	Transposase, IS605 OrfB family
J9253_15030	COG0585	pseudouridine synthase activity
J9253_15040	COG0840	transmembrane signaling receptor activity
J9253_15070	COG2197	response regulator
J9253_15075	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
J9253_15080	COG2205	protein histidine kinase activity
J9253_15105	COG0129	dihydroxy-acid dehydratase activity
J9253_15110	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
J9253_15125	COG0156	8-amino-7-oxononanoate synthase activity
J9253_15130	COG0425	Belongs to the sulfur carrier protein TusA family
J9253_15135	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
J9253_15145	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
J9253_15170	COG1434	Gram-negative-bacterium-type cell wall biogenesis
J9253_15175	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
J9253_15180	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
J9253_15180	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
J9253_15185	COG0802	atpase or kinase
J9253_15190	COG0860	N-Acetylmuramoyl-L-alanine amidase
J9253_15200	COG0009	L-threonylcarbamoyladenylate synthase
J9253_15210	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
J9253_15215	COG2378	regulation of single-species biofilm formation
J9253_15270	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
J9253_15280	COG0330	HflC and HflK could
J9253_15295	COG2205	protein histidine kinase activity
J9253_15295	COG3437	response regulator, receiver
J9253_15295	COG3850	Histidine kinase
J9253_15295	COG4999	Histidine kinase
J9253_15300	COG2204	response regulator
J9253_15315	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
J9253_15360	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
J9253_15380	COG1011	Hydrolase
J9253_15390	COG0494	nUDIX hydrolase
J9253_15430	COG0582	viral genome integration into host DNA
J9253_15510	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
J9253_15525	COG1132	(ABC) transporter
J9253_15560	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
J9253_15575	COG0762	integral membrane protein
J9253_15580	COG1872	DUF167
J9253_15585	COG0724	RNA recognition motif
J9253_15590	COG2918	glutathione biosynthetic process
J9253_15655	COG3597	protein domain associated with
J9253_15685	COG4615	Cyclic peptide transporter
J9253_15695	COG2046	Belongs to the sulfate adenylyltransferase family
J9253_15695	COG0529	Catalyzes the synthesis of activated sulfate
J9253_15710	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
J9253_15725	COG1028	Short-chain dehydrogenase reductase Sdr
J9253_15735	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
J9253_15740	COG2192	nodulation
J9253_15765	COG0076	glutamate decarboxylase activity
J9253_15780	COG2217	Heavy metal translocating P-type atpase
J9253_15785	COG1262	PFAM Formylglycine-generating sulfatase enzyme
J9253_15790	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
J9253_15835	COG4948	Mandelate Racemase Muconate Lactonizing
J9253_15845	COG0436	Aminotransferase
J9253_15850	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
J9253_15855	COG4948	Mandelate Racemase Muconate Lactonizing
J9253_15865	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
J9253_15870	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
J9253_15885	COG2217	Heavy metal translocating P-type atpase
J9253_15900	COG1252	NADH dehydrogenase
J9253_15915	COG5433	transposase activity
J9253_15920	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
J9253_15920	COG0116	Belongs to the methyltransferase superfamily
J9253_15940	COG4452	Inner membrane protein CreD
J9253_15950	COG0735	belongs to the Fur family
J9253_15955	COG0523	cobalamin synthesis protein
J9253_15965	COG4804	nuclease activity
J9253_15970	COG0577	efflux transmembrane transporter activity
J9253_15970	COG1136	(ABC) transporter
J9253_15975	COG4628	conserved protein (DUF2132)
J9253_15995	COG1752	Esterase of the alpha-beta hydrolase superfamily
J9253_16035	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
J9253_16040	COG2922	Belongs to the Smg family
J9253_16045	COG0758	DNA mediated transformation
J9253_16050	COG0301	tRNA thio-modification
J9253_16070	COG0751	glycine-tRNA ligase activity
J9253_16090	COG0339	signal peptide processing
J9253_16095	COG0187	DNA topoisomerase II activity
J9253_16100	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
J9253_16105	COG0592	DNA-directed DNA polymerase activity
J9253_16115	COG0230	Belongs to the bacterial ribosomal protein bL34 family
J9253_16120	COG0594	ribonuclease P activity
J9253_16125	COG0706	membrane insertase activity
J9253_16130	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
J9253_16150	COG4804	nuclease activity
J9253_16175	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
J9253_16230	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
J9253_16245	COG0859	PFAM glycosyl transferase family 9
J9253_16250	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
J9253_16255	COG0196	riboflavin kinase activity
J9253_16260	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
J9253_16265	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
J9253_16270	COG0540	Belongs to the ATCase OTCase family
J9253_16275	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
J9253_16280	COG0058	SHG alpha-glucan phosphorylase activity
J9253_16285	COG0297	glycogen (starch) synthase activity
J9253_16290	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
J9253_16305	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
J9253_16310	COG0166	Belongs to the GPI family
J9253_16320	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
J9253_16325	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
J9253_16330	COG0569	domain protein
J9253_16335	COG2204	response regulator
J9253_16340	COG5000	phosphorelay sensor kinase activity
J9253_16350	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
J9253_16350	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
J9253_16355	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
J9253_16360	COG0242	peptide deformylase activity
J9253_16375	COG0243	molybdopterin cofactor binding
J9253_16380	COG0437	4 iron, 4 sulfur cluster binding
J9253_16385	COG3302	dmso reductase anchor subunit
J9253_16395	COG4681	YaeQ
J9253_16400	COG0604	alcohol dehydrogenase
J9253_16405	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
J9253_16420	COG0513	Belongs to the DEAD box helicase family
J9253_16445	COG0673	inositol 2-dehydrogenase activity
J9253_16460	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
J9253_16465	COG0131	Imidazoleglycerol-phosphate dehydratase
J9253_16470	COG3001	Fructosamine kinase
J9253_16490	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
J9253_16495	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
J9253_16500	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
J9253_16525	COG0277	FAD linked oxidase domain protein
J9253_16530	COG1620	l-lactate permease
J9253_16535	COG2186	Transcriptional regulator
J9253_16540	COG0247	lactate metabolic process
J9253_16555	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
J9253_16580	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
J9253_16600	COG0488	(ABC) transporter
J9253_16605	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
J9253_16625	COG1404	Belongs to the peptidase S8 family
J9253_16635	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
J9253_16640	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
J9253_16645	COG2813	Specifically methylates the guanine in position
J9253_16655	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
J9253_16660	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
J9253_16665	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
J9253_16680	COG0745	RESPONSE REGULATOR receiver
J9253_16685	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
J9253_16705	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
J9253_16745	COG3220	belongs to the UPF0276 family
J9253_16770	COG0675	Transposase, IS605 OrfB family
J9253_16785	COG0521	Mo-molybdopterin cofactor biosynthetic process
J9253_16795	COG1690	Belongs to the RtcB family
J9253_16820	COG0489	protein tyrosine kinase activity
J9253_16820	COG3206	protein involved in exopolysaccharide biosynthesis
J9253_16845	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
J9253_16850	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
J9253_16870	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
J9253_16875	COG0508	dehydrogenase complex catalyzes the overall conversion of
J9253_16880	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
J9253_16905	COG0675	Transposase, IS605 OrfB family
J9253_16910	COG0675	Transposase, IS605 OrfB family
J9253_16990	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
J9253_16990	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
J9253_16995	COG2268	Band 7 protein
J9253_17020	COG3263	regulation of cellular component size
J9253_17035	COG2076	Multidrug Resistance protein
J9253_17040	COG2076	Multidrug Resistance protein
J9253_17045	COG0463	Glycosyl transferase, family 2
J9253_17070	COG0456	acetyltransferase
J9253_17080	COG0500	methyltransferase
J9253_17090	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
J9253_17110	COG1056	cytidyltransferase-related domain
J9253_17110	COG1051	belongs to the nudix hydrolase family
J9253_17115	COG0783	Belongs to the Dps family
J9253_17125	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
J9253_17140	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
J9253_17145	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
J9253_17150	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
J9253_17155	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
J9253_17160	COG0708	Exodeoxyribonuclease III
J9253_17165	COG1752	Esterase of the alpha-beta hydrolase superfamily
J9253_17170	COG2353	YceI-like domain
J9253_17175	COG3038	cytochrome b561
J9253_17180	COG1741	Belongs to the pirin family
J9253_17185	COG0583	DNA-binding transcription factor activity
J9253_17190	COG0586	Pfam SNARE associated Golgi protein
J9253_17195	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
J9253_17200	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
J9253_17205	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
J9253_17210	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
J9253_17215	COG1234	tRNA 3'-trailer cleavage
J9253_17270	COG0795	lipopolysaccharide-transporting ATPase activity
J9253_17275	COG0795	lipopolysaccharide-transporting ATPase activity
J9253_17285	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
J9253_17290	COG0463	Glycosyl transferase, family 2
J9253_17300	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
J9253_17315	COG0635	Involved in the biosynthesis of porphyrin-containing compound
J9253_17325	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
J9253_17330	COG4191	Histidine kinase
J9253_17355	COG0811	peptide transport
J9253_17360	COG0848	biopolymer transport protein
J9253_17365	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
J9253_17370	COG2046	Belongs to the sulfate adenylyltransferase family
J9253_17395	COG2983	Belongs to the UPF0260 family
J9253_17400	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
J9253_17435	COG1061	Type III restriction enzyme res subunit
J9253_17485	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
J9253_17490	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
J9253_17490	COG1017	nitric oxide dioxygenase activity
J9253_17505	COG3002	Belongs to the UPF0753 family
J9253_17515	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
J9253_17520	COG0659	secondary active sulfate transmembrane transporter activity
J9253_17545	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
J9253_17550	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
J9253_17575	COG4451	ribulose bisphosphate carboxylase, small
J9253_17580	COG1850	ribulose-bisphosphate carboxylase activity
J9253_17585	COG0583	DNA-binding transcription factor activity
J9253_17590	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
J9253_17595	COG0784	Response regulator, receiver
J9253_17595	COG2205	protein histidine kinase activity
J9253_17595	COG5002	protein histidine kinase activity
J9253_17600	COG0675	Transposase, IS605 OrfB family
J9253_17660	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
J9253_17680	COG4636	protein conserved in cyanobacteria
J9253_17710	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
J9253_17715	COG0543	2 iron, 2 sulfur cluster binding
J9253_17715	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
J9253_17725	COG3954	Phosphoribulokinase
J9253_17730	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
J9253_17735	COG2027	D-alanyl-D-alanine carboxypeptidase
J9253_17740	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
J9253_17750	COG2204	response regulator
J9253_17760	COG1690	Belongs to the RtcB family
J9253_17765	COG4650	regulator
J9253_17785	COG2081	HI0933 family
J9253_17835	COG0084	hydrolase, TatD family'
J9253_17845	COG0675	Transposase, IS605 OrfB family
J9253_17860	COG1612	heme a metabolic process
J9253_17875	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
J9253_17880	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
J9253_17890	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
J9253_17895	COG1845	cytochrome c oxidase, subunit III
J9253_17920	COG0109	protoheme IX farnesyltransferase activity
J9253_17930	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
J9253_17940	COG1999	signal sequence binding
J9253_17945	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
J9253_17955	COG0577	efflux transmembrane transporter activity
J9253_17975	COG4115	mRNA cleavage
J9253_17980	COG2161	toxin-antitoxin pair type II binding
J9253_17985	COG0367	asparagine synthase
J9253_18005	COG1595	DNA-templated transcription, initiation
J9253_18015	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
J9253_18025	COG1538	Outer membrane efflux protein
J9253_18035	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
J9253_18040	COG3002	Belongs to the UPF0753 family
J9253_18050	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
J9253_18055	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
J9253_18070	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
J9253_18100	COG0826	peptidase U32
J9253_18110	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
J9253_18115	COG2046	Belongs to the sulfate adenylyltransferase family
J9253_18130	COG0563	adenylate kinase activity
J9253_18135	COG1047	Peptidyl-prolyl cis-trans
J9253_18145	COG0205	6-phosphofructokinase activity
J9253_18155	COG0724	RNA recognition motif
J9253_18170	COG2048	Heterodisulfide reductase, subunit B
J9253_18175	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
J9253_18185	COG1233	COG1233 Phytoene dehydrogenase and related
J9253_18190	COG0123	including yeast histone deacetylase and acetoin utilization protein
J9253_18195	COG0045	succinate-CoA ligase (ADP-forming) activity
J9253_18195	COG1042	CoA-binding domain protein
J9253_18195	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
J9253_18205	COG0352	thiamine-phosphate diphosphorylase activity
J9253_18215	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
J9253_18230	COG1385	rRNA (uridine-N3-)-methyltransferase activity
J9253_18235	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
J9253_18245	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
J9253_18255	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
J9253_18260	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
J9253_18265	COG0126	phosphoglycerate kinase activity
J9253_18310	COG0732	type I restriction modification DNA specificity domain
J9253_18315	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
J9253_18330	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
J9253_18335	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
J9253_18380	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
J9253_18440	COG0107	imidazoleglycerol-phosphate synthase activity
J9253_18450	COG0140	phosphoribosyl-ATP diphosphatase activity
J9253_18455	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
J9253_18460	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
J9253_18465	COG0805	protein transport
J9253_18475	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
J9253_18485	COG2022	thiamine diphosphate biosynthetic process
J9253_18500	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
J9253_18515	COG0175	sulfate reduction
J9253_18520	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
J9253_18535	COG2895	sulfate adenylyltransferase (ATP) activity
J9253_18540	COG3273	potassium ion transport
J9253_18540	COG0471	metal ion transport
J9253_18560	COG3876	Protein conserved in bacteria
J9253_18580	COG1805	sodium ion transport
J9253_18590	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
J9253_18600	COG2871	sodium ion transport
J9253_18610	COG0617	tRNA 3'-terminal CCA addition
J9253_18610	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
J9253_18610	COG0517	IMP dehydrogenase activity
J9253_18625	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
J9253_18635	COG0418	dihydroorotase activity
J9253_18640	COG1047	Peptidyl-prolyl cis-trans
J9253_18655	COG0151	Belongs to the GarS family
J9253_18685	COG1217	gtp-binding protein TYPA
J9253_18690	COG2346	COG2346, Truncated hemoglobins
J9253_18710	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
J9253_18720	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
J9253_18725	COG0784	Response regulator, receiver
J9253_18725	COG2205	protein histidine kinase activity
J9253_18725	COG5002	protein histidine kinase activity
J9253_18765	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
J9253_18770	COG1923	regulation of RNA biosynthetic process
J9253_18775	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
J9253_18780	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
J9253_18785	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
J9253_18790	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
J9253_18795	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
J9253_18800	COG0165	Argininosuccinate lyase
J9253_18805	COG3275	phosphorelay sensor kinase activity
J9253_18825	COG0356	it plays a direct role in the translocation of protons across the membrane
J9253_18830	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
J9253_18835	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
J9253_18840	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
J9253_18845	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
J9253_18850	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
J9253_18860	COG0355	proton-transporting ATP synthase activity, rotational mechanism
J9253_18880	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
J9253_18880	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
J9253_18890	COG1444	tRNA N-acetyltransferase activity
J9253_18895	COG1968	undecaprenyl-diphosphatase activity
J9253_18915	COG1131	(ABC) transporter
J9253_18960	COG0675	Transposase, IS605 OrfB family
J9253_18980	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
J9253_18985	COG3122	Protein conserved in bacteria
J9253_19000	COG1278	Cold shock
J9253_19020	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
J9253_19025	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
J9253_19045	COG0540	Belongs to the ATCase OTCase family
J9253_19050	COG0367	asparagine synthase
J9253_19065	COG1162	GTPase activity
J9253_19105	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
J9253_19125	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
J9253_19200	COG1215	transferase activity, transferring glycosyl groups
J9253_19210	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
J9253_19215	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
J9253_19230	COG0247	lactate metabolic process
J9253_19240	COG0004	ammonium transporteR
J9253_19265	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
J9253_19280	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
J9253_19290	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
J9253_19370	COG0018	arginyl-trna synthetase
J9253_19380	COG1187	pseudouridine synthase activity
J9253_19385	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
J9253_19390	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
J9253_19400	COG0686	Belongs to the AlaDH PNT family
J9253_19415	COG1193	negative regulation of DNA recombination
J9253_19420	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
J9253_19425	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
J9253_19435	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
J9253_19470	COG0675	Transposase, IS605 OrfB family
J9253_19485	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
J9253_19500	COG0617	tRNA 3'-terminal CCA addition
J9253_19505	COG0446	pyridine nucleotide-disulphide oxidoreductase
J9253_19520	COG0019	diaminopimelate decarboxylase activity
J9253_19530	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
J9253_19535	COG1121	(ABC) transporter
J9253_19540	COG1108	ABC-type Mn2 Zn2 transport systems permease components
J9253_19545	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
J9253_19550	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
J9253_19555	COG1858	cytochrome C peroxidase
J9253_19560	COG0675	Transposase, IS605 OrfB family
J9253_19570	COG0748	coenzyme F420 binding
J9253_19575	COG1434	Gram-negative-bacterium-type cell wall biogenesis
J9253_19580	COG1720	tRNA m6t6A37 methyltransferase activity
J9253_19585	COG2027	D-alanyl-D-alanine carboxypeptidase
J9253_19590	COG2197	response regulator
J9253_19610	COG5002	protein histidine kinase activity
J9253_19625	COG2197	response regulator
J9253_19675	COG2010	Cytochrome c
J9253_19680	COG0729	surface antigen
J9253_19685	COG2911	Protein conserved in bacteria
J9253_19710	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
J9253_19720	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
J9253_19730	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
J9253_19735	COG0081	regulation of translation
J9253_19740	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
J9253_19750	COG0085	RNA polymerase activity
J9253_19760	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
J9253_19765	COG0049	tRNA binding
J9253_19770	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
J9253_19775	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
J9253_19780	COG0051	transcription antitermination factor activity, RNA binding
J9253_19785	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
J9253_19790	COG0088	Forms part of the polypeptide exit tunnel
J9253_19795	COG0089	rRNA binding
J9253_19800	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
J9253_19805	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
J9253_19810	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
J9253_19815	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
J9253_19820	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
J9253_19825	COG0255	Belongs to the universal ribosomal protein uL29 family
J9253_19830	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
J9253_19835	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
J9253_19840	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
J9253_19845	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
J9253_19850	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
J9253_19855	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
J9253_19860	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
J9253_19865	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
J9253_19875	COG1841	ribosomal large subunit assembly
J9253_19880	COG0200	Binds to the 23S rRNA
J9253_19885	COG0201	protein transport
J9253_19895	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
J9253_19900	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
J9253_19905	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
J9253_19910	COG0202	RNA polymerase activity
J9253_19925	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
J9253_19935	COG0357	Ribosomal RNA small subunit methyltransferase G
J9253_19940	COG1192	Involved in chromosome partitioning
J9253_19945	COG1475	DNA binding
J9253_19950	COG0268	Binds directly to 16S ribosomal RNA
J9253_19955	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
J9253_19955	COG0237	dephospho-CoA kinase activity
J9253_19960	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
J9253_19970	COG1722	exodeoxyribonuclease VII activity
J9253_19975	COG0142	geranyltranstransferase activity
J9253_19980	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
J9253_19995	COG0675	Transposase, IS605 OrfB family
J9253_20040	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
J9253_20045	COG0830	nickel cation binding
J9253_20070	COG0004	ammonium transporteR
J9253_20110	COG1162	GTPase activity
J9253_20120	COG0501	Belongs to the peptidase M48B family
J9253_20125	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
J9253_20130	COG0714	Associated with various cellular activities
J9253_20145	COG2354	Protein conserved in bacteria
J9253_20150	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
J9253_20165	COG0259	pyridoxamine-phosphate oxidase activity
J9253_20190	COG0675	Transposase, IS605 OrfB family
J9253_20195	COG0210	DNA helicase
J9253_20210	COG1671	Belongs to the UPF0178 family
J9253_20225	COG2165	general secretion pathway protein
J9253_20235	COG2165	general secretion pathway protein
J9253_20250	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
J9253_20280	COG1477	protein flavinylation
J9253_20300	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
J9253_20355	COG0586	Pfam SNARE associated Golgi protein
J9253_20360	COG1230	cation diffusion facilitator family transporter
J9253_20380	COG0642	Histidine kinase
J9253_20390	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
J9253_20410	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
J9253_20440	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
J9253_20465	COG1309	transcriptional regulator
J9253_20480	COG1136	(ABC) transporter
J9253_20480	COG4591	ABC-type transport system involved in lipoprotein release permease component
J9253_20485	COG2346	COG2346, Truncated hemoglobins
J9253_20490	COG3154	lipid carrier protein
J9253_20495	COG0826	peptidase U32
J9253_20500	COG0826	peptidase U32
J9253_20550	COG1242	4 iron, 4 sulfur cluster binding
J9253_20555	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
J9253_20560	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
J9253_20565	COG2181	nitrate reductase activity
J9253_20570	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
J9253_20575	COG1140	nitrate reductase beta subunit
J9253_20580	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
J9253_20590	COG2223	nitrite transmembrane transporter activity
J9253_20605	COG3850	Histidine kinase
J9253_20610	COG2197	response regulator
J9253_20680	COG0446	pyridine nucleotide-disulphide oxidoreductase
J9253_20705	COG0642	Histidine kinase
J9253_20710	COG0675	Transposase, IS605 OrfB family
J9253_20720	COG2010	Cytochrome c
J9253_20735	COG1272	protein, Hemolysin III
J9253_20760	COG4771	TonB-dependent receptor
J9253_20785	COG0714	Associated with various cellular activities
J9253_20800	COG2920	part of a sulfur-relay system
J9253_20805	COG0583	DNA-binding transcription factor activity
J9253_20810	COG2198	Histidine kinase
J9253_20810	COG0642	Histidine kinase
J9253_20850	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity