locus-tag	class	description
HZT40_00035	ENOG4105C75	arginyL-tRNA synthetase
HZT40_00110	ENOG4105I08	Pseudouridine synthase
HZT40_00115	ENOG4105C7B	Threonine dehydratase
HZT40_00120	ENOG4105E66	phosphoriboisomerase A
HZT40_00160	ENOG4105E26	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity)
HZT40_00245	ENOG4105D4J	Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate
HZT40_00250	ENOG4107SA8	fad-dependent pyridine nucleotide-disulfide oxidoreductase
HZT40_00255	ENOG4105D18	nicotinate-nucleotide pyrophosphorylase
HZT40_00270	ENOG4105NXV	High-affinity zinc uptake system protein
HZT40_00275	ENOG4105FDK	ABC transporter
HZT40_00285	ENOG4108ZEF	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity)
HZT40_00290	ENOG4105K5D	4fe-4S ferredoxin iroN-sulfur binding
HZT40_00300	ENOG4108R96	Methyltransferase, YaeB family
HZT40_00305	ENOG4107RVU	D-Ala-D-Ala carboxypeptidase 3 (S13) family
HZT40_00320	ENOG4105MA0	exported protein
HZT40_00340	ENOG4105CGV	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity)
HZT40_00365	ENOG4105C64	Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity)
HZT40_00370	ENOG4108VZM	50s ribosomal protein L10
HZT40_00375	ENOG4105KBC	Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity)
HZT40_00395	ENOG4108UHY	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity)
HZT40_00400	ENOG4105CEJ	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity)
HZT40_00405	ENOG4105CGV	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity)
HZT40_00410	ENOG4108Z10	Involved in the binding of tRNA to the ribosomes (By similarity)
HZT40_00415	ENOG4105EEE	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity)
HZT40_00420	ENOG4106U5A	One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity)
HZT40_00425	ENOG4105CFD	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
HZT40_00430	ENOG4105K7S	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity)
HZT40_00435	ENOG4105KAP	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity)
HZT40_00440	ENOG4105CKE	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity)
HZT40_00445	ENOG4108R70	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity)
HZT40_00455	ENOG4105K87	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal
HZT40_00470	ENOG4105CW6	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
HZT40_00475	ENOG4105VBI	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity)
HZT40_00485	ENOG4108R5J	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity)
HZT40_00495	ENOG4108RA9	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity)
HZT40_00500	ENOG4105VPB	50S ribosomal protein L30
HZT40_00505	ENOG4108UZ0	Binds to the 23S rRNA (By similarity)
HZT40_00510	ENOG4105CGG	The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity)
HZT40_00515	ENOG41067V7	50S ribosomal protein L36
HZT40_00520	ENOG4108Z04	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
HZT40_00525	ENOG4108UHH	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity)
HZT40_00530	ENOG4105G6W	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity)
HZT40_00535	ENOG4105CTF	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
HZT40_00550	ENOG4105CZF	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity)
HZT40_00555	ENOG4107RE5	NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity)
HZT40_00565	ENOG4107QJE	Chromosome Partitioning Protein
HZT40_00570	ENOG4105FA0	parb-like partition protein
HZT40_00575	ENOG4105KQV	Binds directly to 16S ribosomal RNA (By similarity)
HZT40_00580	ENOG4108ZQD	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity)
HZT40_00585	ENOG4105DHA	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity (By similarity)
HZT40_00605	ENOG4105C2V	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity)
HZT40_00635	ENOG4105DEK	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity)
HZT40_00660	ENOG4105C59	p-type ATPase
HZT40_00665	ENOG4105C2Z	ATP-dependent CLP protease ATP-binding subunit
HZT40_00695	ENOG4105I7Z	Short-chain dehydrogenase reductase Sdr
HZT40_00700	ENOG4108IQE	Amp-dependent synthetase and ligase
HZT40_00735	ENOG4108IJF	Heavy metal efflux pump, CzcA
HZT40_00740	ENOG4105C1P	efflux transporter, rnd family, mfp subunit
HZT40_00755	ENOG4105BZU	Histidine kinase
HZT40_00765	ENOG41090VX	general secretion pathway protein L
HZT40_00780	ENOG4105GVR	general secretion pathway protein D
HZT40_00805	ENOG4105EY8	ABC transporter
HZT40_00815	ENOG4108HWB	Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity)
HZT40_00840	ENOG4107S6X	Glycosyl transferase, family 2
HZT40_00845	ENOG4108KBE	Glycosyl transferase, family 2
HZT40_00850	ENOG4108UM5	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity)
HZT40_00855	ENOG4108UJD	30S ribosomal protein S9
HZT40_00905	ENOG4108V1J	Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity)
HZT40_00915	ENOG4105D1S	lipid A biosynthesis
HZT40_00925	ENOG4105F7F	Chaperone
HZT40_00930	ENOG4105QFC	Hsc56 co-chaperone of HscC
HZT40_00935	ENOG41087SS	fad dependent oxidoreductase
HZT40_00945	ENOG4105CPC	Aldo Keto reductase
HZT40_00950	ENOG4105D8A	3-Deoxy-D-manno-octulosonic-acid transferase
HZT40_01005	ENOG4108UNC	
HZT40_01035	ENOG4105C4E	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity)
HZT40_01045	ENOG4108JQB	penicillin-binding protein 1C
HZT40_01055	ENOG4108ZGB	N-(5'-phosphoribosyl)anthranilate isomerase
HZT40_01095	ENOG4105DPM	folylpolyglutamate synthase Dihydrofolate synthase
HZT40_01115	ENOG4105CBA	glutamine phosphoribosylpyrophosphate amidotransferase
HZT40_01120	ENOG4108QQZ	ErfK YbiS YcfS YnhG family protein
HZT40_01125	ENOG4105C28	cystathionine
HZT40_01135	ENOG4108W5X	Transcriptional Regulator, LuxR family
HZT40_01140	ENOG4105CFZ	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity)
HZT40_01145	ENOG4105KTH	gatB Yqey
HZT40_01155	ENOG41090R7	Ferric uptake
HZT40_01160	ENOG4105YRI	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity)
HZT40_01175	ENOG4108Z1B	Cyclase dehydrase
HZT40_01190	ENOG4105BZ4	penicillin-binding protein
HZT40_01205	ENOG4105DVT	helicase
HZT40_01215	ENOG4105CAQ	asparagine synthetase
HZT40_01275	ENOG4105WH1	Two component transcriptional regulator luxr family
HZT40_01285	ENOG4105WH1	Two component transcriptional regulator luxr family
HZT40_01345	ENOG4108HMN	Caspase domain
HZT40_01380	ENOG4105CK4	Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity)
HZT40_01385	ENOG410829K	Lysine exporter protein (Lyse ygga)
HZT40_01420	ENOG4105CCD	The exact function is not known. Can catalyze the reduction of a variety of substrates like dimethyl sulfoxide, trimethylamine N-oxide, phenylmethyl sulfoxide and L-methionine sulfoxide. Cannot reduce cyclic N-oxides. Shows no activity as sulfite oxidase (By similarity)
HZT40_01425	ENOG4105DQ2	Is probably involved in the electron transfer between its heme and the molybdenum cofactor of the reductase catalytic subunit YedY (By similarity)
HZT40_01430	ENOG4108UK1	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant (By similarity)
HZT40_01440	ENOG4105DW3	Response regulator receiver modulated metal dependent phosphohydrolase
HZT40_01460	ENOG4105D7D	AAA ATPase
HZT40_01550	ENOG4105FAE	von Willebrand factor, type A
HZT40_01600	ENOG4105DJ9	glucan biosynthesis protein
HZT40_01630	ENOG4107QHF	type ii secretion system protein e
HZT40_01635	ENOG4107QQG	Dehydrogenase
HZT40_01670	ENOG4105CK0	Membrane bOund o-acyl transferase mboat family protein
HZT40_01680	ENOG4105K64	Glycosyl transferase, family 2
HZT40_01700	ENOG4105JNK	Glycosyl transferase (Group 1
HZT40_01705	ENOG4106N3V	dolichyl-phosphate beta-D-mannosyltransferase (EC 2.4.1.83)
HZT40_01730	ENOG4105C1W	two component, sigma54 specific, transcriptional regulator, Fis family
HZT40_01735	ENOG4107TUY	Histidine kinase
HZT40_01740	ENOG4105C4K	Nad synthetase
HZT40_01755	ENOG4105DWR	Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity)
HZT40_01785	ENOG4105CHR	reductase
HZT40_01865	ENOG4108RG0	uracil-dna glycosylase
HZT40_01890	ENOG4105EKQ	RNA-directed DNA polymerase
HZT40_01895	ENOG4105DYN	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. May be involved in the integration of spacer DNA into the CRISPR cassette (By similarity)
HZT40_01955	ENOG4108W8W	CRISPR-associated RAMP protein, Csm3 family
HZT40_01965	ENOG410695F	Crispr-associated protein, Csm1 family
HZT40_02015	ENOG4108NVM	synthesis repressor PhaR
HZT40_02020	ENOG4105CHR	reductase
HZT40_02025	ENOG4105CHU	acetyl-coa acetyltransferase
HZT40_02035	ENOG4105D1N	poly(r)-hydroxyalkanoic acid synthase, class
HZT40_02060	ENOG4105DEA	Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation
HZT40_02065	ENOG4105CCQ	Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity)
HZT40_02075	ENOG4105C6P	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity)
HZT40_02080	ENOG4105K70	DNA-binding protein
HZT40_02105	ENOG4107TF3	peptidylprolyl cis-trans isomerase
HZT40_02110	ENOG4105CIW	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity)
HZT40_02130	ENOG4105D6S	protein involved in catabolism of external DNA
HZT40_02145	ENOG4105MK2	5-formyltetrahydrofolate cyclo-ligase
HZT40_02155	ENOG4105E9H	Lytic Murein transglycosylase
HZT40_02170	ENOG4107RZZ	dna polymerase iii epsilon subunit
HZT40_02180	ENOG4105CEY	Amp-dependent synthetase and ligase
HZT40_02200	ENOG4105C3J	Cysteine desulfurase
HZT40_02205	ENOG4107XTC	May be involved in the formation or repair of Fe-S clusters present in iron-sulfur proteins
HZT40_02210	ENOG4108Z4V	iron-sulfur cluster assembly
HZT40_02215	ENOG4108SWN	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA (By similarity)
HZT40_02220	ENOG4105C9I	Chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Has a low intrinsic ATPase activity which is markedly stimulated by HscB
HZT40_02225	ENOG4108ZIT	Ferredoxin, 2FE-2S
HZT40_02230	ENOG4105WVQ	Fe-S assembly protein IscX
HZT40_02240	ENOG4105DA0	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity)
HZT40_02265	ENOG4105CSJ	Enoyl- acyl-carrier-protein reductase NADH
HZT40_02280	ENOG4108DMA	Nad-dependent epimerase dehydratase
HZT40_02290	ENOG4105EY8	ABC transporter
HZT40_02320	ENOG4105F7M	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit (By similarity)
HZT40_02360	ENOG4105CK0	Membrane bOund o-acyl transferase mboat family protein
HZT40_02375	ENOG4105F8J	Adenylate Guanylate cyclase
HZT40_02385	ENOG4105IJJ	transcriptional regulator, crp fnr family
HZT40_02410	ENOG4108JJ6	Type I secretion system ATPase
HZT40_02415	ENOG4107QZV	Type I secretion membrane fusion protein
HZT40_02520	ENOG4105CRP	Part of the ABC transporter FtsEX involved in
HZT40_02530	ENOG4105CCP	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC)
HZT40_02550	ENOG4105K4H	Nlp p60 protein
HZT40_02580	ENOG4105XJC	Two component transcriptional regulator (Winged helix family
HZT40_02585	ENOG4105IFJ	Histidine kinase
HZT40_02595	ENOG4105SKE	transcriptional Regulator LysR family
HZT40_02610	ENOG4105CHU	acetyl-coa acetyltransferase
HZT40_02620	ENOG4105CGU	Enoyl-CoA hydratase
HZT40_02625	ENOG4105DYT	3-hydroxyacyl-CoA dehydrogenase
HZT40_02630	ENOG4105E39	Enoyl-CoA hydratase
HZT40_02650	ENOG4105KHV	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity)
HZT40_02680	ENOG4105C32	Amino acid ABC transporter (Permease)
HZT40_02685	ENOG4105CF8	branched-chain amino acid ABC transporter, permease
HZT40_02690	ENOG4105C0Z	ABC transporter
HZT40_02750	ENOG4105DYN	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. May be involved in the integration of spacer DNA into the CRISPR cassette (By similarity)
HZT40_02775	ENOG4105XMH	SpoVT AbrB domain protein
HZT40_02785	ENOG4105DYN	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. May be involved in the integration of spacer DNA into the CRISPR cassette (By similarity)
HZT40_02850	ENOG4107QMH	DNA methylase
HZT40_02895	ENOG4107S21	permease
HZT40_02905	ENOG4108UXE	Protein tyrosine phosphatase
HZT40_02910	ENOG4105D6J	arsenicaL-resistance protein
HZT40_02940	ENOG4105DEU	major facilitator superfamily
HZT40_02960	ENOG4105CYQ	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity)
HZT40_03060	ENOG410605C	May protect the nitrogenase Fe-Mo protein from oxidative damage (By similarity)
HZT40_03065	ENOG4105XV5	nifz family
HZT40_03075	ENOG4108P4H	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity)
HZT40_03080	ENOG4105F4R	Transcriptional regulator mode
HZT40_03105	ENOG4105CGB	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system (By similarity)
HZT40_03110	ENOG4108S6J	ABC transporter, periplasmic molybdate-binding protein
HZT40_03115	ENOG4105F4R	Transcriptional regulator mode
HZT40_03120	ENOG4107XWS	modD protein
HZT40_03125	ENOG4107QUT	magnesium and cobalt transport protein CorA
HZT40_03150	ENOG4105C0Q	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity)
HZT40_03170	ENOG4105CHR	reductase
HZT40_03240	ENOG4105CCY	NADH flavin oxidoreductase, NADH oxidase
HZT40_03245	ENOG4105ETT	transcriptional Regulator, LysR family
HZT40_03285	ENOG4107QW4	alcohol dehydrogenase
HZT40_03290	ENOG4108ZXC	Two component transcriptional regulator, luxr family
HZT40_03355	ENOG4108V3G	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity)
HZT40_03370	ENOG4105EWI	Short-chain dehydrogenase reductase Sdr
HZT40_03375	ENOG41084M5	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity)
HZT40_03400	ENOG4105C8E	extradiol ring-cleavage dioxygenase class IIi protein subunit b
HZT40_03405	ENOG4105D1X	Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity)
HZT40_03410	ENOG4108ZG0	Ompa motb domain protein
HZT40_03435	ENOG4105UYK	outer membrane protein a
HZT40_03450	ENOG4105CNK	Required, probably indirectly, for the hydroxylation of 2-octaprenylphenol to 2-octaprenyl-6-hydroxy-phenol, the fourth step in ubiquinone biosynthesis (By similarity)
HZT40_03470	ENOG4105CHU	acetyl-coa acetyltransferase
HZT40_03480	ENOG4105CHR	reductase
HZT40_03485	ENOG4105CEY	Amp-dependent synthetase and ligase
HZT40_03490	ENOG4105C3J	Cysteine desulfurase
HZT40_03495	ENOG4108Z3N	Transcriptional regulator
HZT40_03500	ENOG4105RVE	Uncharacterized protein conserved in bacteria (DUF2136)
HZT40_03505	ENOG4105DVF	Cytosine-specific methyltransferase
HZT40_03530	ENOG4105DC6	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity)
HZT40_03535	ENOG4105DG1	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity)
HZT40_03550	ENOG4105DP5	Catalyzes the biosynthesis of agmatine from arginine (By similarity)
HZT40_03565	ENOG4105VNG	YcgL domain-containing protein
HZT40_03590	ENOG4105C59	p-type ATPase
HZT40_03595	ENOG4105C59	p-type ATPase
HZT40_03605	ENOG4107NQ8	LysR family Transcriptional regulator
HZT40_03610	ENOG4108Z0T	Part of a sulfur-relay system (By similarity)
HZT40_03620	ENOG4105CQX	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity)
HZT40_03625	ENOG41081XQ	Conserved Protein
HZT40_03630	ENOG4105KDC	50s ribosomal protein l28
HZT40_03635	ENOG4105W0E	50S ribosomal protein L33
HZT40_03675	ENOG4105CH2	amidohydrolase
HZT40_03685	ENOG4105CVE	Lytic murein transglycosylase
HZT40_03690	ENOG4105C21	Displays ATPase and GTPase activities (By similarity)
HZT40_03695	ENOG4107RM2	PTS IIA-like nitrogen-regulatory protein PtsN
HZT40_03700	ENOG41080QH	sigma 54 modulation protein ribosomal protein S30EA
HZT40_03705	ENOG4105DTW	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity)
HZT40_03710	ENOG4108IUZ	ABC transporter
HZT40_03730	ENOG4105C2X	Arabinose 5-phosphate isomerase
HZT40_03740	ENOG4105E2N	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity)
HZT40_03750	ENOG4105CN0	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity)
HZT40_03755	ENOG4105CF9	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation (By similarity)
HZT40_03770	ENOG4107YJ4	chain length determinant protein
HZT40_03785	ENOG4105CG5	Glycosyl transferase (Group 1
HZT40_03790	ENOG4105CAQ	asparagine synthetase
HZT40_03795	ENOG4105CPK	Glycosyl transferase (Group 1
HZT40_03800	ENOG4108KMV	Glycosyl transferase (Group 1
HZT40_03810	ENOG4107TAE	Glycosyl transferase (Group 1
HZT40_03835	ENOG4105EUH	cytochrome C oxidase, cbb3-type, subunit i
HZT40_03850	ENOG4105D6P	C-type cytochrome. Part of the cbb3-type cytochrome c oxidase complex (By similarity)
HZT40_03855	ENOG4105C58	cytochrome c oxidase accessory protein ccog
HZT40_03865	ENOG4105D4P	Coproporphyrinogen iii oxidase
HZT40_03870	ENOG4105DS0	Transcriptional regulator, Crp Fnr family
HZT40_03880	ENOG4106PT6	cdpdiacylglycerol-serine O-phosphatidyltransferase
HZT40_03890	ENOG4108UN4	phage SPO1 DNA polymerase-related protein
HZT40_03895	ENOG4105KEG	ribosomal-protein-alanine acetyltransferase
HZT40_03900	ENOG4105DJ0	Poly(A) Polymerase
HZT40_03910	ENOG4105BZS	acriflavin resistance protein
HZT40_03940	ENOG4105N1F	Hnh endonuclease
HZT40_03950	ENOG4108RZE	Tetr family transcriptional regulator
HZT40_03985	ENOG4105CRK	lysyL-tRNA synthetase
HZT40_04155	ENOG4105WXW	Antirepressor
HZT40_04225	ENOG4108I7H	Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity)
HZT40_04275	ENOG4105D0B	Nitrogenase protein alpha chain
HZT40_04280	ENOG4105DK8	Nitrogenase molybdenum-iron cofactor biosynthesis protein NifN
HZT40_04285	ENOG4107SJ9	decarboxylase
HZT40_04295	ENOG41067HS	methyltransferase
HZT40_04300	ENOG4105CBG	Sulfatase
HZT40_04310	ENOG4105MIR	Phenylalanine 4-monooxygenase
HZT40_04325	ENOG4105BZ8	glutamate synthase
HZT40_04335	ENOG4108UR2	Nitrogen fixation protein NifX
HZT40_04360	ENOG4105WCA	Ferredoxin
HZT40_04365	ENOG4107QY0	Catalyzes the dehydration of methylthioribulose-1- phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1- phosphate (DK-MTP-1-P) (By similarity)
HZT40_04380	ENOG4105C6K	Malic enzyme
HZT40_04395	ENOG4105PWN	phosphate abc transporter
HZT40_04410	ENOG4105ERH	Fumarylacetoacetate hydrolase
HZT40_04415	ENOG4107QKA	exodeoxyribonuclease V beta
HZT40_04430	ENOG4105ECY	inositol monophosphatase
HZT40_04455	ENOG4105CSM	endonuclease III
HZT40_04480	ENOG4108R3D	Electron transport complex
HZT40_04490	ENOG4105C2S	Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity)
HZT40_04495	ENOG4108Z1W	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity)
HZT40_04510	ENOG4108Z03	MAF-like protein
HZT40_04530	ENOG4105D1U	peptidase U62 modulator of DNA gyrase
HZT40_04535	ENOG4105CMS	peptidase U62, modulator of DNA gyrase
HZT40_04540	ENOG4105NBK	UPF0345 protein
HZT40_04545	ENOG4108V3E	phosphoribosylglycinamide formyltransferase
HZT40_04565	ENOG4108VKV	Monofunctional biosynthetic peptidoglycan transglycosylase
HZT40_04600	ENOG4105CSG	Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps (By similarity)
HZT40_04615	ENOG4105EC0	Required for nucleoid occlusion (NO) phenomenon, which prevents Z-ring formation and cell division over the nucleoid. Acts as a DNA-associated cell division inhibitor that binds simultaneously chromosomal DNA and FtsZ, and disrupts the assembly of FtsZ polymers. SlmA-DNA-binding sequences (SBS) are dispersed on non-Ter regions of the chromosome, preventing FtsZ polymerization at these regions (By similarity)
HZT40_04635	ENOG4105EJ9	Membrane
HZT40_04650	ENOG4105E09	nadh pyrophosphatase
HZT40_04665	ENOG4105DDQ	anthranilate synthase
HZT40_04675	ENOG4108VXP	Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity)
HZT40_04705	ENOG4105C34	Pseudouridine synthase
HZT40_04715	ENOG4108JQ7	(ABC) transporter
HZT40_04725	ENOG4107258	Transcriptional regulator
HZT40_04780	ENOG4105D9N	nucleoside
HZT40_04830	ENOG4108Z8G	Alkylphosphonate utilization operon protein PhnA
HZT40_04835	ENOG4105D6A	Electron transport complex
HZT40_04840	ENOG4105DZ0	fad dependent oxidoreductase
HZT40_04845	ENOG4105DP0	ferredoxin-NADP reductase
HZT40_04850	ENOG4107QM9	Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (By similarity)
HZT40_04855	ENOG4105D3U	Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity)
HZT40_04875	ENOG4105C7D	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
HZT40_04885	ENOG4107835	probably involved in intracellular septation (By similarity)
HZT40_04890	ENOG4107RTD	sua5 ycio yrdc ywlc family protein
HZT40_04895	ENOG4108Z4T	Peptidase M50
HZT40_04900	ENOG4105C31	Tryptophanyl-tRNA synthetase
HZT40_04905	ENOG4108KVX	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves (By similarity)
HZT40_04910	ENOG4105K8I	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity)
HZT40_04915	ENOG4105K77	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity)
HZT40_04920	ENOG4105C62	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity)
HZT40_04925	ENOG4105C0D	helicase
HZT40_04930	ENOG4105D06	uba thif-type nad fad binding protein
HZT40_04955	ENOG4108ZF1	Transcriptional regulator, BadM Rrf2 family
HZT40_04960	ENOG4105M85	Bola protein
HZT40_04965	ENOG4105C7R	Atpase associated with various cellular activities aaa_3
HZT40_05015	ENOG4108JEB	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity)
HZT40_05020	ENOG4107RT4	flavin reductase domain protein
HZT40_05030	ENOG41080BE	Methyl-accepting chemotaxis sensory transducer
HZT40_05045	ENOG4105CQX	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity)
HZT40_05055	ENOG4105C4R	Atp-dependent dna helicase
HZT40_05080	ENOG4105C65	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity)
HZT40_05085	ENOG4108Z11	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity)
HZT40_05090	ENOG4105D1W	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity)
HZT40_05100	ENOG4105C66	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity)
HZT40_05110	ENOG4107YIM	Involved in the transcription termination process (By similarity)
HZT40_05120	ENOG4105C7P	2-oxoglutarate dehydrogenase, E1
HZT40_05125	ENOG4105CEH	Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity)
HZT40_05155	ENOG4105DH7	May be involved in recombination (By similarity)
HZT40_05165	ENOG4105CKH	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity)
HZT40_05225	ENOG4105DUY	Ser-Asp rich fibrinogen-binding, bone sialoprotein-binding protein
HZT40_05250	ENOG4105K89	arsenate reductase
HZT40_05255	ENOG4105CS1	NAD(P)H quinone oxidoreductase
HZT40_05265	ENOG4108UH8	Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity)
HZT40_05280	ENOG4106F3G	Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5- dihydroxy-2-cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon (By similarity)
HZT40_05305	ENOG4105CER	acetyl-CoA carboxylase biotin carboxylase
HZT40_05320	ENOG4105D7A	ATP-binding protein
HZT40_05340	ENOG4105CEZ	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) (By similarity)
HZT40_05345	ENOG4105DBD	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation (By similarity)
HZT40_05350	ENOG4105E7H	involved in the assembly of LPS in the outer leaflet of the outer membrane. Determines N-hexane tolerance and is involved in outer membrane permeability. Essential for envelope biogenesis (By similarity)
HZT40_05365	ENOG4105KUZ	arsenate reductase
HZT40_05375	ENOG4105CB8	Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity)
HZT40_05400	ENOG4105C1P	efflux transporter, rnd family, mfp subunit
HZT40_05405	ENOG4105BZS	acriflavin resistance protein
HZT40_05430	ENOG4105SVQ	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters. Also required for regulation of fis expression (By similarity)
HZT40_05445	ENOG41062D9	Histidine kinase
HZT40_05455	ENOG4105C0H	protease
HZT40_05500	ENOG4105IH7	synthase
HZT40_05510	ENOG4105EGS	Mechanosensitive ion channel
HZT40_05520	ENOG4105C8D	Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity)
HZT40_05525	ENOG4105C70	Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity)
HZT40_05530	ENOG4105XX3	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic (By similarity)
HZT40_05535	ENOG4105CE5	Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity)
HZT40_05540	ENOG4105CHG	glycolate oxidase (iron-sulfur subunit)
HZT40_05550	ENOG4105CQB	FAD linked oxidase domain protein
HZT40_05555	ENOG4105WMR	Protein CrcB homolog
HZT40_05560	ENOG4105CPM	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity)
HZT40_05570	ENOG4107GFK	fumarate
HZT40_05580	ENOG4105C5I	Dehydrogenase
HZT40_05585	ENOG4105CVE	Lytic murein transglycosylase
HZT40_05590	ENOG4107STF	Involved in phosphonate degradation (By similarity)
HZT40_05605	ENOG4105CJR	Integral membrane protein (MviN
HZT40_05615	ENOG4107QR8	Thioredoxin
HZT40_05620	ENOG4108HRN	Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity)
HZT40_05625	ENOG4105RX7	peptidase S8 and S53, subtilisin, kexin, sedolisin
HZT40_05630	ENOG4105CII	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity)
HZT40_05640	ENOG4105KK9	This protein binds to 23S rRNA in the presence of protein L20 (By similarity)
HZT40_05650	ENOG41082J7	Rhodanese domain protein
HZT40_05660	ENOG4105Y75	tpr repeat protein
HZT40_05665	ENOG4105E33	succinate dehydrogenase
HZT40_05680	ENOG410612Q	succinate dehydrogenase (cytochrome b-556 subunit)
HZT40_05690	ENOG4105C7P	2-oxoglutarate dehydrogenase, E1
HZT40_05695	ENOG4105D6Z	AFG1 family ATPase
HZT40_05710	ENOG4105CE9	30S ribosomal protein S2
HZT40_05715	ENOG4105CU7	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity)
HZT40_05720	ENOG4105C41	Catalyzes the reversible phosphorylation of UMP to UDP (By similarity)
HZT40_05725	ENOG4108VCV	Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity)
HZT40_05735	ENOG4105KNE	Phosphatidate cytidylyltransferase
HZT40_05740	ENOG4105CEA	Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity)
HZT40_05745	ENOG4105DZP	Membrane-associated zinc metalloprotease
HZT40_05750	ENOG4105E1Z	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HZT40_05760	ENOG4105D7M	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity)
HZT40_05765	ENOG4105DAF	Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity)
HZT40_05770	ENOG4105D0V	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity)
HZT40_05780	ENOG4108UH2	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity)
HZT40_05805	ENOG4105C0B	DNA polymerase III (alpha subunit)
HZT40_05810	ENOG4107YJ4	chain length determinant protein
HZT40_05815	ENOG4105D75	Capsular exopolysaccharide family
HZT40_05820	ENOG4105CU6	carbamoyl-phosphate synthetase ammonia chain
HZT40_05825	ENOG4108UKH	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity)
HZT40_05860	ENOG4105M2J	Glutaredoxin
HZT40_05885	ENOG4108Z66	YbaK ebsC protein
HZT40_05890	ENOG4108ZAI	phosphatidylglycerophosphatase a
HZT40_05895	ENOG4105C20	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity)
HZT40_05930	ENOG4105DN3	alpha-2-macroglobulin domain protein
HZT40_05935	ENOG4108JQB	penicillin-binding protein 1C
HZT40_05945	ENOG4105XJC	Two component transcriptional regulator (Winged helix family
HZT40_05955	ENOG4105EZE	Cupin 4 family protein
HZT40_05960	ENOG4107QTF	adenylosuccinate lyase
HZT40_05965	ENOG4108IYU	L-aspartate oxidase
HZT40_05970	ENOG4105EMN	RNA polymerase sigma factor
HZT40_05990	ENOG4105C0H	protease
HZT40_06000	ENOG4105C4S	Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity)
HZT40_06005	ENOG4105C3F	Signal peptidase i
HZT40_06020	ENOG4105CWT	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity)
HZT40_06035	ENOG4105CSZ	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate (By similarity)
HZT40_06040	ENOG4105KJV	Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity)
HZT40_06045	ENOG4105BZU	Histidine kinase
HZT40_06050	ENOG4105C6T	cysteine synthase
HZT40_06065	ENOG4105BZT	Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity)
HZT40_06070	ENOG4105C77	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity)
HZT40_06090	ENOG4105C4F	May be involved in recombinational repair of damaged DNA (By similarity)
HZT40_06095	ENOG4105F91	Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity)
HZT40_06100	ENOG4105CI8	Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons (By similarity)
HZT40_06120	ENOG4105CG9	aspartate racemase
HZT40_06125	ENOG4108JPX	Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity)
HZT40_06145	ENOG4105C6T	cysteine synthase
HZT40_06170	ENOG4105CT3	Monooxygenase
HZT40_06210	ENOG4108IQF	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity)
HZT40_06215	ENOG4105C7F	AcnD-accessory protein PrpF
HZT40_06225	ENOG4105BZN	citrate synthase
HZT40_06230	ENOG4105CR4	methylisocitrate lyase
HZT40_06240	ENOG4105C3Y	UTP-glucose-1-phosphate uridylyltransferase
HZT40_06245	ENOG4107QYX	exodeoxyribonuclease v alpha
HZT40_06280	ENOG4105CD8	aminopeptidase N
HZT40_06290	ENOG4105C8H	hydrogenase maturation protein Hypf
HZT40_06295	ENOG4105C8H	hydrogenase maturation protein Hypf
HZT40_06310	ENOG4105C45	hydrogenase expression formation protein (HypE)
HZT40_06320	ENOG4105C59	p-type ATPase
HZT40_06330	ENOG4107QPA	Cleaves GlcNAc linked beta-1,4 to MurNAc tripeptides (By similarity)
HZT40_06340	ENOG4105CQS	hydrogenase expression formation protein HypD
HZT40_06345	ENOG41082MF	Hydrogenase assembly chaperone hypC hupF
HZT40_06355	ENOG4105C4W	S-formylglutathione hydrolase
HZT40_06395	ENOG4105DPX	Hydrogenase, large subunit
HZT40_06410	ENOG4107ZIF	6-carboxy-5,6,7,8-tetrahydropterin synthase
HZT40_06485	ENOG4108R4Z	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine (By similarity)
HZT40_06490	ENOG4105C3M	thioredoxin reductase
HZT40_06495	ENOG4105CNU	cell division protein FtsK
HZT40_06500	ENOG4107Y7W	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane) (By similarity)
HZT40_06515	ENOG4105CG2	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity)
HZT40_06530	ENOG4105CAS	nag kinase
HZT40_06535	ENOG4105CHU	acetyl-coa acetyltransferase
HZT40_06545	ENOG4108Z1K	This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity)
HZT40_06550	ENOG4105CJS	Phosphopantothenoylcysteine decarboxylase
HZT40_06555	ENOG4105W5Q	DNA repair protein (RadC
HZT40_06575	ENOG4105CIW	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity)
HZT40_06585	ENOG4108I0Q	anthranilate phosphoribosyltransferase
HZT40_06590	ENOG4105DK0	Indole-3-glycerol phosphate synthase
HZT40_06605	ENOG4108JIJ	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second (By similarity)
HZT40_06610	ENOG4105K90	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
HZT40_06615	ENOG4105CFG	Acts as a chaperone (By similarity)
HZT40_06620	ENOG4105BZ5	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity)
HZT40_06625	ENOG4105DUK	Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity)
HZT40_06635	ENOG4105CUC	YeeE YedE family protein
HZT40_06640	ENOG4105FAE	von Willebrand factor, type A
HZT40_06650	ENOG4105DT1	RuBisCO catalyzes two reactions the carboxylation of D- ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate
HZT40_06655	ENOG4105DUM	transcriptional regulator, lysR family
HZT40_06665	ENOG4105C24	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
HZT40_06670	ENOG4107QM1	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity)
HZT40_06675	ENOG4108JQ1	Dehydrogenase
HZT40_06700	ENOG4105CMY	5-enolpyruvylshikimate-3-phosphate synthase
HZT40_06705	ENOG4105CAT	Cytidine monophosphate kinase
HZT40_06710	ENOG4105CAV	thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity)
HZT40_06715	ENOG41080YA	This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity)
HZT40_06720	ENOG4105CFV	Tetratricopeptide repeat protein
HZT40_06725	ENOG4106EG9	Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) (By similarity)
HZT40_06730	ENOG41075W9	High frequency lysogenization protein HflD homolog
HZT40_06760	ENOG4105KAE	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation (By similarity)
HZT40_06765	ENOG4105C2Z	ATP-dependent CLP protease ATP-binding subunit
HZT40_06800	ENOG4105YAZ	4-amino-4-deoxychorismate lyase
HZT40_06810	ENOG4105HHA	aminodeoxychorismate lyase
HZT40_06815	ENOG4108ZMD	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity)
HZT40_06820	ENOG4107QRG	dna polymerase iii
HZT40_06835	ENOG4105E1F	short-chain dehydrogenase reductase
HZT40_06855	ENOG4105C9M	aspartyl-trna synthetase
HZT40_06865	ENOG4105C4H	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity)
HZT40_06870	ENOG4105EXC	Acyl-transferase
HZT40_06875	ENOG4105GAK	amidohydrolase 2
HZT40_06880	ENOG4108N2Y	auxin Efflux
HZT40_06885	ENOG4105CJE	phosphoribulokinase (EC 2.7.1.19)
HZT40_06890	ENOG4105C3R	Methionine synthase
HZT40_06915	ENOG4107QMV	Part of the ABC transporter complex PstSACB involved in phosphate import (By similarity)
HZT40_06925	ENOG4105E2Z	phosphate ABC transporter (Permease
HZT40_06930	ENOG4105BZY	Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity)
HZT40_06980	ENOG4105CA9	Pyruvate kinase
HZT40_07000	ENOG4107QQX	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity)
HZT40_07005	ENOG4108J5G	6-phosphogluconate dehydrogenase
HZT40_07010	ENOG4105E0X	reductase
HZT40_07015	ENOG4105CF3	3-Hydroxyisobutyrate dehydrogenase
HZT40_07025	ENOG4105C8T	Leucyl-tRNA synthetase
HZT40_07050	ENOG4108IUW	ABC transporter
HZT40_07055	ENOG4105BZM	domain protein
HZT40_07085	ENOG4105BZU	Histidine kinase
HZT40_07090	ENOG4105BZU	Histidine kinase
HZT40_07105	ENOG4105DUM	transcriptional regulator, lysR family
HZT40_07115	ENOG4108VFZ	ribulose bisphosphate carboxylase, small
HZT40_07130	ENOG4105FAE	von Willebrand factor, type A
HZT40_07150	ENOG4105ED1	spovr family
HZT40_07155	ENOG4106AKX	UPF0229 protein
HZT40_07160	ENOG4105CYN	Serine protein kinase
HZT40_07165	ENOG4105CT7	inner membrane cred family protein
HZT40_07175	ENOG4105DJ1	Phosphoenolpyruvate Carboxylase
HZT40_07195	ENOG4105CJX	Molecular chaperone. Has ATPase activity (By similarity)
HZT40_07210	ENOG4105C3K	feS assembly ATPase SufC
HZT40_07220	ENOG4105EUB	pirin domain protein
HZT40_07290	ENOG4105EXC	Acyl-transferase
HZT40_07295	ENOG4105CM0	Catalyzes the synthesis of GMP from XMP (By similarity)
HZT40_07300	ENOG4105CP4	Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity)
HZT40_07325	ENOG4105DPZ	Two component transcriptional regulator (Winged helix family
HZT40_07330	ENOG4105CK6	Two component transcriptional regulator (Winged helix family
HZT40_07335	ENOG4105BZU	Histidine kinase
HZT40_07340	ENOG4105BZU	Histidine kinase
HZT40_07345	ENOG4105BZU	Histidine kinase
HZT40_07360	ENOG4105DS0	Transcriptional regulator, Crp Fnr family
HZT40_07375	ENOG4105DAQ	Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity)
HZT40_07380	ENOG4105DH5	Responsible for the end-turnover of tRNA specifically removes the terminal AMP residue from uncharged tRNA (tRNA-C-C-A). Also appears to be involved in tRNA biosynthesis (By similarity)
HZT40_07410	ENOG4105C1H	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity)
HZT40_07415	ENOG4107V1M	polysaccharide export protein
HZT40_07420	ENOG4105CMR	udp-glucose 4-epimerase
HZT40_07425	ENOG41083P1	competence protein ComEA helix-hairpin-helix repeat protein
HZT40_07600	ENOG4105PFA	Catalyzes the conversion of 5-hydroxyuridine (ho5U) to 5-methoxyuridine (mo5U) at position 34 in tRNA (By similarity)
HZT40_07620	ENOG4105RHY	Pfam:UPF0157
HZT40_07765	ENOG4107QSI	ABC, transporter
HZT40_07770	ENOG4105C1J	atp-dependent rna helicase
HZT40_07780	ENOG4105CCZ	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity)
HZT40_07795	ENOG4105FCQ	metal-binding, possibly nucleic acid-binding protein
HZT40_07805	ENOG4105E2X	shikimate dehydrogenase
HZT40_07810	ENOG4105D52	delta-aminolevulinic acid dehydratase
HZT40_07825	ENOG4107QQ4	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity)
HZT40_07835	ENOG4105EPW	hflc protein
HZT40_07850	ENOG4108I0Q	anthranilate phosphoribosyltransferase
HZT40_07860	ENOG4108Z2X	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine (By similarity)
HZT40_07865	ENOG4108IAA	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity)
HZT40_07890	ENOG4105CQU	Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity)
HZT40_07895	ENOG4105D60	lipoprotein releasing system transmembrane protein
HZT40_07900	ENOG4105D60	lipoprotein releasing system transmembrane protein
HZT40_07915	ENOG4108HWB	Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity)
HZT40_07940	ENOG4108UW5	maltose o-acetyltransferase
HZT40_07945	ENOG4105CKK	Glycosyl transferase, family 2
HZT40_07955	ENOG4105D3Q	Sugar transferase
HZT40_07965	ENOG4108QV3	biosynthesis protein
HZT40_07980	ENOG4105C6M	Alpha-keto-beta-hydroxylacyl reductoisomerase
HZT40_07985	ENOG4108ZP8	Acetolactate synthase small subunit
HZT40_07990	ENOG4105C7K	acetolactate synthase
HZT40_08000	ENOG4105C55	Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs
HZT40_08015	ENOG4105CUT	histidyl-tRNA synthetase
HZT40_08020	ENOG4105N21	Membrane
HZT40_08050	ENOG4105D86	that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity)
HZT40_08055	ENOG4105T95	Thiol disulfide interChange protein
HZT40_08060	ENOG4105C13	Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity)
HZT40_08070	ENOG4105C35	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity)
HZT40_08095	ENOG4105PFA	Catalyzes the conversion of 5-hydroxyuridine (ho5U) to 5-methoxyuridine (mo5U) at position 34 in tRNA (By similarity)
HZT40_08105	ENOG4105CW7	secretion protein, HlyD family
HZT40_08110	ENOG4105C0R	drug resistance transporter emrb qaca subfamily
HZT40_08115	ENOG4105DA6	Catalyzes the conversion of 5-methoxyuridine (mo5U) to uridine-5-oxyacetic acid (cmo5U) at position 34 in tRNA. May also participate in the methylation of uridine-5-oxyacetic acid (cmo5U) to uridine-5-oxyacetic acid methyl ester (mcmo5U) (By similarity)
HZT40_08120	ENOG4108R85	Short chain dehydrogenase
HZT40_08140	ENOG4108EQH	DNA internalization-related competence protein ComEC Rec2
HZT40_08145	ENOG4108EQH	DNA internalization-related competence protein ComEC Rec2
HZT40_08170	ENOG4107XFB	conserved TRANSMEMBRANE PROTEIN
HZT40_08175	ENOG4105CSU	acyl-Coa dehydrogenase
HZT40_08180	ENOG4108R5F	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity)
HZT40_08190	ENOG4105CX6	glutaminyL-tRNA synthetase
HZT40_08200	ENOG4105CKD	glutathione-regulated potassium-efflux system protein
HZT40_08205	ENOG4108K2R	Glutathione-regulated potassium-efflux system ancillary protein
HZT40_08215	ENOG4105P9C	Participates in cysteine desulfuration mediated by SufS. Cysteine desulfuration mobilizes sulfur from L-cysteine to yield L-alanine and constitutes an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules. Functions as a sulfur acceptor for SufS, by mediating the direct transfer of the sulfur atom from the S-sulfanylcysteine of SufS, an intermediate product of cysteine desulfuration process (By similarity)
HZT40_08225	ENOG4105DSB	aldose 1-epimerase
HZT40_08235	ENOG4108JJ9	ABC, transporter
HZT40_08245	ENOG4105CFY	cytochrome d ubiquinol oxidase, subunit ii
HZT40_08250	ENOG4105C4M	(Ubiquinol oxidase) subunit I
HZT40_08255	ENOG4105C90	Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity)
HZT40_08300	ENOG4105DC1	bifunctional purine biosynthesis protein purh
HZT40_08310	ENOG4105DWA	May conjugate Arg from its aminoacyl-tRNA to the N- termini of proteins containing an N-terminal aspartate or glutamate
HZT40_08315	ENOG4105DS0	Transcriptional regulator, Crp Fnr family
HZT40_08360	ENOG4107QIJ	Aconitate hydratase 2
HZT40_08380	ENOG4107QN2	dihydrolipoyl dehydrogenase
HZT40_08385	ENOG4105C7S	Dehydrogenase
HZT40_08440	ENOG4105DUM	transcriptional regulator, lysR family
HZT40_08455	ENOG4105C59	p-type ATPase
HZT40_08470	ENOG4105C58	cytochrome c oxidase accessory protein ccog
HZT40_08475	ENOG4105CGR	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity)
HZT40_08495	ENOG4106032	Glutathionylspermidine synthase
HZT40_08515	ENOG4108YZN	class I peptide chain release factor
HZT40_08520	ENOG4105BZ1	(ABC) transporter
HZT40_08590	ENOG4105IPS	esterase
HZT40_08595	ENOG4107TF3	peptidylprolyl cis-trans isomerase
HZT40_08605	ENOG4105E9K	Isocitrate dehydrogenase
HZT40_08610	ENOG4105VS7	Bifunctional enzyme which can phosphorylate or dephosphorylate isocitrate dehydrogenase (IDH) on a specific serine residue. This is a regulatory mechanism which enables bacteria to bypass the Krebs cycle via the glyoxylate shunt in response to the source of carbon. When bacteria are grown on glucose, IDH is fully active and unphosphorylated, but when grown on acetate or ethanol, the activity of IDH declines drastically concomitant with its phosphorylation (By similarity)
HZT40_08615	ENOG4105CB5	ATP-dependent DNA helicase recG
HZT40_08625	ENOG4105C2C	drug resistance transporter, Bcr CflA
HZT40_08635	ENOG4105C3G	gtp-binding protein
HZT40_08640	ENOG4108ZPD	The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity)
HZT40_08645	ENOG4105KW6	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity)
HZT40_08665	ENOG4105CTR	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity)
HZT40_08670	ENOG41081V9	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein (By similarity)
HZT40_08685	ENOG4105C7E	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity)
HZT40_08690	ENOG4105C8K	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity)
HZT40_08695	ENOG4105EQY	Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity)
HZT40_08705	ENOG4106855	Competence protein
HZT40_08715	ENOG4105JCS	prepilin peptidase dependent protein
HZT40_08730	ENOG4105CD3	dihydroorotase
HZT40_08740	ENOG4107MKT	Stringent starvation protein a
HZT40_08745	ENOG4105EIX	cytochrome c1
HZT40_08750	ENOG4105DJ5	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity)
HZT40_08755	ENOG4108R5F	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity)
HZT40_08765	ENOG4105CIH	Imidazole acetol-phosphate transaminase
HZT40_08790	ENOG4105C5H	ABC transporter
HZT40_08820	ENOG4105C3J	Cysteine desulfurase
HZT40_08825	ENOG4107XTC	May be involved in the formation or repair of Fe-S clusters present in iron-sulfur proteins
HZT40_08830	ENOG4105QAS	Iron-sulfur cluster assembly accessory protein
HZT40_08835	ENOG4108ZF1	Transcriptional regulator, BadM Rrf2 family
HZT40_08840	ENOG41065RQ	ADP-ribosylation crystallin J1
HZT40_08855	ENOG4108642	UPF0391 membrane protein
HZT40_08865	ENOG4105VDW	Csbd family
HZT40_08885	ENOG4105C9Q	fumarate hydratase class II
HZT40_08890	ENOG41070EG	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes (By similarity)
HZT40_08905	ENOG4105D0M	Protease HtpX homolog
HZT40_08910	ENOG4108V0P	LemA family
HZT40_08920	ENOG4108JA0	Oxidoreductase, FAD NAD(P)-binding domain protein
HZT40_08925	ENOG4108V0P	LemA family
HZT40_09005	ENOG4105U82	Ferredoxin
HZT40_09010	ENOG4105KXW	Ferredoxin
HZT40_09015	ENOG4105CNW	domain protein
HZT40_09030	ENOG4105P1D	4fe-4s ferredoxin, iron-sulfur binding
HZT40_09035	ENOG4105CGC	Nitrogenase cofactor biosynthesis protein NifB
HZT40_09090	ENOG4105BZU	Histidine kinase
HZT40_09100	ENOG4105C01	Dihydroxy-acid dehydratase
HZT40_09115	ENOG4108JUA	Transcriptional regulator
HZT40_09135	ENOG4105DS4	PAS PAC sensor Signal transduction histidine kinase
HZT40_09295	ENOG4105VY0	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters (By similarity)
HZT40_09310	ENOG4107QP2	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity)
HZT40_09320	ENOG4105DJ4	phosphatidylserine decarboxylase
HZT40_09325	ENOG4105C76	Specifically methylates the 50S ribosomal protein L3 on a specific glutamine residue (By similarity)
HZT40_09340	ENOG4105E18	UPF0276 protein
HZT40_09350	ENOG4105CEJ	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity)
HZT40_09375	ENOG4105CSS	phenylalanyl-tRNA synthetase (alpha subunit)
HZT40_09380	ENOG4108YZX	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity)
HZT40_09385	ENOG41082NX	50s ribosomal protein l35
HZT40_09395	ENOG4105C22	threonyL-tRNA synthetase
HZT40_09465	ENOG4105EGZ	biosynthesis protein
HZT40_09480	ENOG4108RYC	glycosyltransferase
HZT40_09500	ENOG4108RB3	Capsular polysaccharide biosynthesis protein
HZT40_09505	ENOG4107V1M	polysaccharide export protein
HZT40_09510	ENOG4107YJ4	chain length determinant protein
HZT40_09545	ENOG4107RDB	Major Facilitator
HZT40_09555	ENOG4107RHB	Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S- adenosylmethionine. Has broad substrate specificity with 6- aminopurine nucleosides as preferred substrates (By similarity)
HZT40_09560	ENOG4108UGV	hypoxanthine phosphoribosyltransferase
HZT40_09575	ENOG4105D0M	Protease HtpX homolog
HZT40_09580	ENOG4105C24	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
HZT40_09600	ENOG4107FCW	Abortive infection protein
HZT40_09605	ENOG41080HT	Transcriptional regulator, arsr family
HZT40_09610	ENOG4105CJM	Binding-protein-dependent transport systems, inner membrane component
HZT40_09615	ENOG4105C2T	Binding-protein-dependent transport systems, inner membrane component
HZT40_09620	ENOG4105C3U	ABC transporter
HZT40_09625	ENOG4105C3U	ABC transporter
HZT40_09635	ENOG4106R49	Methyltransferase
HZT40_09645	ENOG4105BZ6	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity)
HZT40_09680	ENOG410626R	Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity)
HZT40_09690	ENOG4105BZ6	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity)
HZT40_09705	ENOG4105CA4	amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity)
HZT40_09715	ENOG4105NDF	NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity)
HZT40_09760	ENOG4105C5U	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity)
HZT40_09790	ENOG4105BZ1	(ABC) transporter
HZT40_09800	ENOG4105E3A	(ABC) transporter
HZT40_09805	ENOG4105DA5	(ABC) transporter
HZT40_09810	ENOG4105CC0	LysR family Transcriptional regulator
HZT40_09830	ENOG4105VM8	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding (By similarity)
HZT40_09835	ENOG4105CFH	Aspartokinase
HZT40_09840	ENOG4105CIM	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity)
HZT40_09850	ENOG4105C68	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity)
HZT40_09855	ENOG4107TH8	cina domain protein
HZT40_09860	ENOG4108E8C	) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity)
HZT40_09870	ENOG4105EI2	Pseudouridine synthase
HZT40_09885	ENOG4105KJF	protein tyrosine phosphatase
HZT40_09890	ENOG4105EYW	Ion transport protein
HZT40_09920	ENOG4105NDH	peptidase s1 and s6 chymotrypsin hap
HZT40_09925	ENOG4107QJR	hflk protein
HZT40_09930	ENOG4105EPW	hflc protein
HZT40_09940	ENOG4105C49	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine (By similarity)
HZT40_09945	ENOG4105C91	Plays an important role in the de novo pathway of purine nucleotide biosynthesis
HZT40_09950	ENOG4105CUZ	uba thif-type nad fad binding protein
HZT40_09965	ENOG4105DFG	type I secretion outer membrane protein
HZT40_09975	ENOG4108JJ6	Type I secretion system ATPase
HZT40_10040	ENOG4108UQQ	Electron transport complex
HZT40_10045	ENOG4108E8M	Required for nitrogen fixation. May be part of a membrane complex functioning as an intermediate in the electron transport to nitrogenase (By similarity)
HZT40_10050	ENOG4105VDB	UPF0125 protein
HZT40_10055	ENOG4105DN9	Na H antiporter
HZT40_10060	ENOG4105PUF	Ferredoxin, 2FE-2S
HZT40_10100	ENOG4105MPD	Cytochrome
HZT40_10115	ENOG4105CWG	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34 (By similarity)
HZT40_10120	ENOG4105C3F	Signal peptidase i
HZT40_10125	ENOG4105CNG	UPF0061 protein
HZT40_10140	ENOG4105WH1	Two component transcriptional regulator luxr family
HZT40_10145	ENOG4105BZU	Histidine kinase
HZT40_10155	ENOG4105C0Y	Responsible for the amidation of carboxylic groups at position A and C of either cobyrinic acid or hydrogenobrynic acid. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity)
HZT40_10160	ENOG4105DNZ	Alpha Beta Hydrolase
HZT40_10175	ENOG4105CDV	Ompa motb domain protein
HZT40_10205	ENOG4107QS1	Cytochrome C Oxidase, Subunit III
HZT40_10215	ENOG4105BZ9	Cytochrome C oxidase, subunit I
HZT40_10260	ENOG4105FT1	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I (By similarity)
HZT40_10265	ENOG4105BZ9	Cytochrome C oxidase, subunit I
HZT40_10270	ENOG4105CV4	Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) (By similarity)
HZT40_10280	ENOG4107ZT5	Thiol disulfide interchange protein
HZT40_10285	ENOG4107TQK	Catalyzes the oxidation of the C8 methyl side group on heme O porphyrin ring into a formyl group (By similarity)
HZT40_10300	ENOG4105D6E	homoserine dehydrogenase
HZT40_10305	ENOG4105CHM	Aminotransferase
HZT40_10315	ENOG4105DG1	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity)
HZT40_10335	ENOG4105CGZ	zinc metallopeptidase
HZT40_10355	ENOG4105CDW	Resistance protein
HZT40_10380	ENOG4105K4H	Nlp p60 protein
HZT40_10385	ENOG4106678	morphogenetic protein associated with SpoVID
HZT40_10415	ENOG4105CDF	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity)
HZT40_10425	ENOG4105E99	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity)
HZT40_10430	ENOG4105CEK	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity)
HZT40_10440	ENOG4105CK6	Two component transcriptional regulator (Winged helix family
HZT40_10460	ENOG4105BZU	Histidine kinase
HZT40_10465	ENOG4105BZF	Glycosyl transferase (Group 1
HZT40_10495	ENOG410814C	multidrug resistance protein
HZT40_10535	ENOG4105CGH	5'-nucleotidase
HZT40_10565	ENOG4108ZHJ	Organic hydroperoxide resistance protein
HZT40_10570	ENOG4105E7U	AraC family transcriptional regulator
HZT40_10580	ENOG4105DHI	Methyltransferase
HZT40_10610	ENOG4105DIV	Catalyzes the conversion of acetaldehyde to acetyl-CoA, using NAD( ) and coenzyme A. Is the final enzyme in the meta- cleavage pathway for the degradation of aromatic compounds (By similarity)
HZT40_10615	ENOG4105DF3	Catalyzes the retro-aldol cleavage of 4-hydroxy-2- oxopentanoate to pyruvate and acetaldehyde. Is involved in the meta-cleavage pathway for the degradation of aromatic compounds (By similarity)
HZT40_10635	ENOG4107R73	Mate efflux family protein
HZT40_10640	ENOG4105CNV	Aldolase
HZT40_10675	ENOG4105E4C	Lytic transglycosylase catalytic
HZT40_10685	ENOG4105D0A	hydroxylase
HZT40_10710	ENOG4105W8B	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division (By similarity)
HZT40_10740	ENOG41067CV	Integrase
HZT40_10750	ENOG4105CQ3	Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity)
HZT40_10785	ENOG4105C3X	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity)
HZT40_10840	ENOG4105DE5	Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity)
HZT40_10845	ENOG4105EYH	Exonuclease
HZT40_10850	ENOG4107RH8	nuclease SbcCD subunit D
HZT40_10925	ENOG4105CP4	Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity)
HZT40_10935	ENOG4105BZU	Histidine kinase
HZT40_10950	ENOG4105DQQ	Major facilitator superfamily MFS_1
HZT40_10955	ENOG4108Z0T	Part of a sulfur-relay system (By similarity)
HZT40_10960	ENOG4105CRU	nitrate reductase, alpha subunit
HZT40_10970	ENOG41076YT	nitrate reductase, gamma subunit
HZT40_10980	ENOG4105CVM	Molybdenum cofactor synthesis domain protein
HZT40_10985	ENOG4105CM1	Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity)
HZT40_11020	ENOG4105C1M	carbamoyl-phosphate synthetase glutamine chain
HZT40_11035	ENOG4105CJ0	Catalyzes the oxidation of erythronate-4-phosphate to 3- hydroxy-2-oxo-4-phosphonooxybutanoate (By similarity)
HZT40_11040	ENOG4105N5T	Radical SAM Protein
HZT40_11065	ENOG4105M00	molybdopterin converting factor, subunit 1
HZT40_11080	ENOG4105D6C	Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity)
HZT40_11100	ENOG4105EC0	Required for nucleoid occlusion (NO) phenomenon, which prevents Z-ring formation and cell division over the nucleoid. Acts as a DNA-associated cell division inhibitor that binds simultaneously chromosomal DNA and FtsZ, and disrupts the assembly of FtsZ polymers. SlmA-DNA-binding sequences (SBS) are dispersed on non-Ter regions of the chromosome, preventing FtsZ polymerization at these regions (By similarity)
HZT40_11110	ENOG4105D05	Receptor
HZT40_11115	ENOG4105F64	nitrite reductase
HZT40_11125	ENOG4105DSQ	Nitric oxide reductase
HZT40_11130	ENOG4108VKQ	nitriC oxide reductase
HZT40_11230	ENOG4105VT3	DNA binding domain protein, excisionase family
HZT40_11275	ENOG4105W5Q	DNA repair protein (RadC
HZT40_11330	ENOG4105C73	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity)
HZT40_11375	ENOG4107QMS	site-determining protein
HZT40_11395	ENOG4105DG1	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity)
HZT40_11400	ENOG4105C9G	DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity)
HZT40_11425	ENOG4105CPK	Glycosyl transferase (Group 1
HZT40_11435	ENOG4108SHN	Glycosyl transferase, family 2
HZT40_11440	ENOG4105CPK	Glycosyl transferase (Group 1
HZT40_11450	ENOG4105CG5	Glycosyl transferase (Group 1
HZT40_11465	ENOG4105CG5	Glycosyl transferase (Group 1
HZT40_11485	ENOG4105CV6	ABC transporter, permease
HZT40_11495	ENOG4108UJV	acyl-CoA thioesterase i
HZT40_11505	ENOG4105KK6	nuclease
HZT40_11520	ENOG4105CK3	Lysine 2,3-aminomutase YodO family protein
HZT40_11525	ENOG4105DRH	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity)
HZT40_11530	ENOG4105CAP	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P (By similarity)
HZT40_11545	ENOG4107RAB	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity)
HZT40_11550	ENOG4105DRC	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity)
HZT40_11555	ENOG4105CVM	Molybdenum cofactor synthesis domain protein
HZT40_11585	ENOG4105DAT	cobalamin (vitamin b12) biosynthesis cbix protein
HZT40_11595	ENOG4108194	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis (By similarity)
HZT40_11600	ENOG4105HJX	Biotin- acetyl-CoA-carboxylase ligase
HZT40_11605	ENOG4105D8G	Major Facilitator superfamily
HZT40_11610	ENOG4105D10	5-enolpyruvylshikimate-3-phosphate phospholyase
HZT40_11620	ENOG41080RH	Thioredoxin
HZT40_11625	ENOG4108UMA	3-octaprenyl-4-hydroxybenzoate carboxy-lyase
HZT40_11635	ENOG4105BZU	Histidine kinase
HZT40_11640	ENOG4108YY1	This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity)
HZT40_11645	ENOG4105D6X	Specifically methylates guanosine-37 in various tRNAs (By similarity)
HZT40_11655	ENOG4105K5M	30s ribosomal protein S16
HZT40_11660	ENOG4108XC3	NADH ubiquinone oxidoreductase
HZT40_11680	ENOG4105CB9	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
HZT40_11690	ENOG4108JU6	CBS domain protein
HZT40_11695	ENOG4105DNJ	May play a role in the repair of endogenous alkylation damage (By similarity)
HZT40_11710	ENOG4105M6F	mutator MutT protein
HZT40_11715	ENOG4105C5V	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity)
HZT40_11720	ENOG4105CI6	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving
HZT40_11735	ENOG4105C7C	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity)
HZT40_11745	ENOG4105CIT	This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity)
HZT40_11750	ENOG4105K7E	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly (By similarity)
HZT40_11755	ENOG4105CPF	Cell wall formation (By similarity)
HZT40_11760	ENOG4105DFU	Cell wall formation (By similarity)
HZT40_11765	ENOG4105DVQ	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity)
HZT40_11775	ENOG4105DMZ	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity)
HZT40_11780	ENOG4105CPY	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity)
HZT40_11790	ENOG4107EEN	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity)
HZT40_11795	ENOG4105CJN	penicillin-binding protein
HZT40_11805	ENOG4105CGJ	Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity)
HZT40_11820	ENOG4105E6M	Sulphatase-modifying factor protein
HZT40_11845	ENOG4105E6M	Sulphatase-modifying factor protein
HZT40_11885	ENOG4105DFP	Integrase
HZT40_11900	ENOG4105C2N	RNA methyltransferase TrmH family group 3
HZT40_11920	ENOG4108VXP	Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity)
HZT40_11930	ENOG4105VJP	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell (By similarity)
HZT40_11935	ENOG4107QMS	site-determining protein
HZT40_11940	ENOG4105K7U	Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization (By similarity)
HZT40_11955	ENOG4108JA2	transcriptioN-repair coupling factor
HZT40_11980	ENOG4105EKQ	RNA-directed DNA polymerase
HZT40_12110	ENOG4105E18	UPF0276 protein
HZT40_12125	ENOG4107S2Z	UPF0761 membrane protein
HZT40_12145	ENOG4105C1W	two component, sigma54 specific, transcriptional regulator, Fis family
HZT40_12150	ENOG4105BZU	Histidine kinase
HZT40_12160	ENOG4105CHH	sulfate transporter
HZT40_12165	ENOG4108V9Q	carbonic anhydrase
HZT40_12170	ENOG4105K63	Thioredoxin
HZT40_12175	ENOG4105C8A	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP (By similarity)
HZT40_12245	ENOG4105E3W	Two component transcriptional regulator (Winged helix family
HZT40_12250	ENOG4105EB3	Histidine kinase
HZT40_12260	ENOG4105CJ4	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity)
HZT40_12265	ENOG4105CDU	Replicative dna helicase
HZT40_12275	ENOG4105VH8	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity)
HZT40_12280	ENOG4108ZDX	Binds together with S18 to 16S ribosomal RNA (By similarity)
HZT40_12285	ENOG4105D9P	serine threonine protein kinase
HZT40_12320	ENOG4105E4C	Lytic transglycosylase catalytic
HZT40_12330	ENOG4105D1Z	hydroxypyruvate reductase
HZT40_12340	ENOG4108JQC	penicillin-binding protein 1A
HZT40_12345	ENOG4108JQC	penicillin-binding protein 1A
HZT40_12370	ENOG4105E4G	Type IV pilus
HZT40_12380	ENOG4105D49	3-dehydroquinate synthase
HZT40_12400	ENOG41084GC	stage II sporulation protein
HZT40_12405	ENOG4108MJI	response regulator
HZT40_12420	ENOG4105BZU	Histidine kinase
HZT40_12430	ENOG4105C4Q	deoxyguanosinetriphosphate triphosphohydrolase-like protein
HZT40_12435	ENOG4107S2Z	UPF0761 membrane protein
HZT40_12460	ENOG4105C32	Amino acid ABC transporter (Permease)
HZT40_12465	ENOG4105C0Z	ABC transporter
HZT40_12470	ENOG4108IV0	ABC, transporter
HZT40_12495	ENOG4107SCJ	type I restriction enzyme EcoKI subunit R
HZT40_12505	ENOG4105D5S	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity)
HZT40_12535	ENOG4105MUA	Resistance protein
HZT40_12580	ENOG41063Z6	transcriptional regulator, lysR family
HZT40_12585	ENOG4105SWR	response regulator
HZT40_12610	ENOG4105C2Z	ATP-dependent CLP protease ATP-binding subunit
HZT40_12620	ENOG4107P0T	Selenium-dependent molybdenum hydroxylase system protein, YqeB family
HZT40_12630	ENOG4107QUY	Guanine deaminase
HZT40_12645	ENOG4108JQ9	ABC transporter
HZT40_12655	ENOG4105CE2	Aldehyde oxidase and xanthine dehydrogenase, molybdopterin binding
HZT40_12695	ENOG4105DHG	Allantoate amidinohydrolase
HZT40_12700	ENOG4108Z2U	ureidoglycolate hydrolase
HZT40_12705	ENOG4105C2W	permease
HZT40_12710	ENOG4105D6T	Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity)
HZT40_12730	ENOG4105CQM	Urea amidohydrolase subunit alpha
HZT40_12740	ENOG4105F5P	DNA-damage-inducible protein d
HZT40_12750	ENOG4107R3N	Filamentation induced by cAMP protein fic
HZT40_12775	ENOG4105DZR	Type I site-specific deoxyribonuclease
HZT40_12785	ENOG4105MMR	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly (By similarity)
HZT40_12790	ENOG4108YH3	Required for maturation of urease via the functional incorporation of the urease nickel metallocenter (By similarity)
HZT40_12815	ENOG4105M2J	Glutaredoxin
HZT40_12825	ENOG4105MWK	D-amino acid dehydrogenase, small subunit
HZT40_12840	ENOG4105D8W	glucose-6-phosphate 1-dehydrogenase
HZT40_12875	ENOG4105D44	asparaginase
HZT40_12925	ENOG4108TGK	Low-potential electron donor to a number of redox enzymes (By similarity)
HZT40_12935	ENOG4108R96	Methyltransferase, YaeB family
HZT40_12950	ENOG4105FZE	dinitrogenase iron-molybdenum cofactor biosynthesis
HZT40_12955	ENOG4107IVC	4Fe-4S ferredoxin, iron-sulfur binding
HZT40_12960	ENOG41084IN	nitrogen fixation protein
HZT40_12965	ENOG4105CY9	nitrogenase molybdenum-iron protein beta chain
HZT40_12970	ENOG4105D0B	Nitrogenase protein alpha chain
HZT40_12975	ENOG4105DSM	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex, which has 2 components the iron protein and the molybdenum-iron protein (By similarity)
HZT40_12980	ENOG4108K8Z	nad( )--dinitrogen-reductase ADP-d-ribosyltransferase
HZT40_13010	ENOG4107XH4	PPIases accelerate the folding of proteins (By similarity)
HZT40_13020	ENOG4105C1W	two component, sigma54 specific, transcriptional regulator, Fis family
HZT40_13025	ENOG4105BZU	Histidine kinase
HZT40_13055	ENOG4107QY8	reductase
HZT40_13060	ENOG4105QAX	Iron-sulfur
HZT40_13075	ENOG4105CVS	RNA methyltransferase TrmH family, group 1
HZT40_13085	ENOG4105C0Z	ABC transporter
HZT40_13105	ENOG4108UH4	Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity)
HZT40_13130	ENOG4107S5T	Carbohydrate kinase
HZT40_13145	ENOG4105C8N	cysteinyl-tRNA synthetase
HZT40_13150	ENOG4108EQM	faD-dependent pyridine nucleotide-disulfide oxidoreductase
HZT40_13155	ENOG4105CJ9	Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity)
HZT40_13165	ENOG4105BZU	Histidine kinase
HZT40_13170	ENOG4105VFQ	Histone family protein nucleoid-structuring protein H-NS
HZT40_13200	ENOG4105C02	permease
HZT40_13210	ENOG4108ZG0	Ompa motb domain protein
HZT40_13215	ENOG4105D3G	Pseudouridine synthase
HZT40_13225	ENOG41081QV	Universal stress protein
HZT40_13235	ENOG4105CBF	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity)
HZT40_13260	ENOG4107ZBH	radical SAM domain protein
HZT40_13310	ENOG4105E0X	reductase
HZT40_13335	ENOG4105WDY	DNA (cytosine-5-)-methyltransferase
HZT40_13340	ENOG4105C9U	ATP-dependent DNA helicase RecQ
HZT40_13350	ENOG4105CSA	Coproporphyrinogen iii oxidase
HZT40_13365	ENOG4108VDT	Glycosyl transferase family protein
HZT40_13375	ENOG4105CKK	Glycosyl transferase, family 2
HZT40_13390	ENOG4108M8S	permease YjgP YjgQ family protein
HZT40_13410	ENOG4105CCA	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle (By similarity)
HZT40_13415	ENOG4108YX9	iron--sulfur cluster insertion protein erpA
HZT40_13430	ENOG4105C0N	N-acetylglutamate semialdehyde dehydrogenase
HZT40_13440	ENOG4108YXA	Membrane
HZT40_13445	ENOG4105EJF	Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity)
HZT40_13460	ENOG4105DSY	exodeoxyribonuclease V, gamma
HZT40_13500	ENOG4108KQJ	Type 11 methyltransferase
HZT40_13510	ENOG4105EY8	ABC transporter
HZT40_13525	ENOG4105D3Q	Sugar transferase
HZT40_13530	ENOG4107QKV	phosphomannomutase
HZT40_13590	ENOG4105C5H	ABC transporter
HZT40_13600	ENOG4105C5Q	Transcriptional regulator
HZT40_13605	ENOG4105ESV	Glycosyl transferase, family 4
HZT40_13630	ENOG4108VAU	general secretion pathway protein G
HZT40_13635	ENOG4105D7Q	type ii secretion system
HZT40_13640	ENOG4105D7Q	type ii secretion system
HZT40_13645	ENOG4107QHF	type ii secretion system protein e
HZT40_13675	ENOG4108ETH	Formylglycinamide ribotide synthetase
HZT40_13685	ENOG4108RCM	Nitroreductase
HZT40_13690	ENOG4105EXN	Sulfate transport protein CysZ
HZT40_13705	ENOG4105C26	Dehydrogenase
HZT40_13710	ENOG4108RW0	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity)
HZT40_13720	ENOG4107QRI	Phosphoketolase
HZT40_13725	ENOG4105CCY	NADH flavin oxidoreductase, NADH oxidase
HZT40_13735	ENOG4107STW	synthase
HZT40_13740	ENOG4106N16	had-superfamily hydrolase, subfamily iib
HZT40_13750	ENOG4107QW3	Sucrose phosphorylase
HZT40_13760	ENOG4105D7Q	type ii secretion system
HZT40_13765	ENOG4107QHF	type ii secretion system protein e
HZT40_13770	ENOG4105GVR	general secretion pathway protein D
HZT40_13790	ENOG4105D4F	Synthesizes selenophosphate from selenide and ATP (By similarity)
HZT40_13795	ENOG4105CR7	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA (By similarity)
HZT40_13800	ENOG4107QIX	Phosphoglucomutase (EC 5.4.2.2
HZT40_13810	ENOG4108ZF1	Transcriptional regulator, BadM Rrf2 family
HZT40_13815	ENOG4105DDT	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity)
HZT40_13825	ENOG4105FFN	Specifically methylates the guanosine in position 1516 of 16S rRNA (By similarity)
HZT40_13830	ENOG4105VRX	Protein slyX homolog
HZT40_13835	ENOG4105CDH	Citrulline--aspartate ligase
HZT40_13845	ENOG4105CH5	extracellular solute-binding protein, family 7
HZT40_13865	ENOG4105DHQ	Histidine kinase
HZT40_13870	ENOG4105F44	Two component transcriptional regulator, winged helix family
HZT40_13875	ENOG4108YYX	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome. Modulates RNA-binding and helicase activities of the degradosome (By similarity)
HZT40_13885	ENOG4105DWT	malate dehydrogenase (quinone)
HZT40_13900	ENOG4105CET	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria (By similarity)
HZT40_13905	ENOG4105W49	UPF0434 protein
HZT40_13910	ENOG4105CHD	Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) (By similarity)
HZT40_13915	ENOG4105BZ1	(ABC) transporter
HZT40_13935	ENOG4105E4C	Lytic transglycosylase catalytic
HZT40_13945	ENOG4105DMJ	Catalyzes the transfer of an acetyl group from acetyl- CoA to tetrahydrodipicolinate (By similarity)
HZT40_13950	ENOG4105CHM	Aminotransferase
HZT40_13955	ENOG4105C8U	phosphate abc transporter
HZT40_13970	ENOG4108UTW	Plays a role in the regulation of phosphate uptake
HZT40_13975	ENOG4105CK6	Two component transcriptional regulator (Winged helix family
HZT40_13980	ENOG4105BZU	Histidine kinase
HZT40_13990	ENOG4105CJ3	phosphate transporter
HZT40_13995	ENOG4107IX6	phosphate transport regulator
HZT40_14000	ENOG4105F10	Catalyzes the hydrolysis of the pyrophosphate bond of UDP-2,3-diacylglucosamine to yield 2,3-diacylglucosamine 1- phosphate (lipid X) and UMP (By similarity)
HZT40_14040	ENOG4107YRI	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) (By similarity)
HZT40_14090	ENOG4105CZN	Potassium uptake protein
HZT40_14095	ENOG4105BZS	acriflavin resistance protein
HZT40_14110	ENOG4105C1P	efflux transporter, rnd family, mfp subunit
HZT40_14130	ENOG4105EZ7	amino acid ABC transporter
HZT40_14135	ENOG4107QXX	ABC transporter
HZT40_14140	ENOG4105CE8	Transfers the fatty acyl group on membrane lipoproteins (By similarity)
HZT40_14145	ENOG4108JU5	Magnesium and cobalt efflux protein
HZT40_14150	ENOG4105KGE	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity)
HZT40_14155	ENOG4105C9A	Phoh family
HZT40_14165	ENOG4105BZU	Histidine kinase
HZT40_14170	ENOG4105D4A	Cell wall formation (By similarity)
HZT40_14175	ENOG4105D6P	C-type cytochrome. Part of the cbb3-type cytochrome c oxidase complex (By similarity)
HZT40_14195	ENOG41080IJ	Diacylglycerol kinase
HZT40_14215	ENOG4105C7K	acetolactate synthase
HZT40_14220	ENOG4107EER	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity)
HZT40_14230	ENOG4107QHM	Sulfite reductase
HZT40_14250	ENOG4105C3T	may be the GTPase, regulating ATP sulfurylase activity (By similarity)
HZT40_14255	ENOG4105DE7	Sulfate ABC transporter periplasmic sulfate-binding protein
HZT40_14285	ENOG4107R11	Transcriptional regulator
HZT40_14310	ENOG4105CBI	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HZT40_14315	ENOG4105KE9	The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity)
HZT40_14320	ENOG4105D43	The glycine cleavage system catalyzes the degradation of glycine (By similarity)
HZT40_14325	ENOG4105SC1	monovalent cation H antiporter subunit E
HZT40_14350	ENOG4108ZE9	Monovalent cation H antiporter subunit C
HZT40_14355	ENOG4108JPZ	Monovalent cation H antiporter subunit D
HZT40_14360	ENOG4105CMZ	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone (By similarity)
HZT40_14365	ENOG4105ES3	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
HZT40_14370	ENOG4105CQV	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
HZT40_14430	ENOG4105DY2	Paraquat-inducible protein b
HZT40_14435	ENOG4105F1S	paraquat-inducible protein a
HZT40_14440	ENOG4105F1S	paraquat-inducible protein a
HZT40_14450	ENOG4105DGM	nitrilase cyanide hydratase and apolipoprotein n-acyltransferase
HZT40_14455	ENOG4108TEB	UPF0114 protein
HZT40_14480	ENOG4105CA0	peroxidase
HZT40_14510	ENOG4108DNI	pyridine nucleotide-disulfide oxidoreductase
HZT40_14520	ENOG4105DHQ	Histidine kinase
HZT40_14525	ENOG4105XJC	Two component transcriptional regulator (Winged helix family
HZT40_14615	ENOG4106H3A	restriction
HZT40_14625	ENOG41065RQ	ADP-ribosylation crystallin J1
HZT40_14635	ENOG4105UEI	Transcriptional Regulator AraC Family
HZT40_14675	ENOG4105MYN	Zinc uptake regulation protein
HZT40_14695	ENOG4107RBB	ABC transporter, permease
HZT40_14710	ENOG4105WQ5	TonB family
HZT40_14715	ENOG4105M15	transport protein ExbD
HZT40_14720	ENOG4105M8K	biopolymer transport protein
HZT40_14735	ENOG4108ESX	Receptor
HZT40_14740	ENOG4107E2E	PKHD-type hydroxylase
HZT40_14745	ENOG4107QKW	extracellular solute-binding protein family 1
HZT40_14795	ENOG4105D3R	alkyl hydroperoxide reductase
HZT40_14870	ENOG4107QVT	Binding-protein-dependent transport systems, inner membrane component
HZT40_14875	ENOG4105C53	Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity)
HZT40_14895	ENOG4105D6C	Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity)
HZT40_14925	ENOG4105BZU	Histidine kinase
HZT40_14930	ENOG4105BZU	Histidine kinase
HZT40_14935	ENOG4105BZU	Histidine kinase
HZT40_14940	ENOG4105M3Z	response regulator
HZT40_14945	ENOG4105BZU	Histidine kinase
HZT40_14955	ENOG4105BZU	Histidine kinase
HZT40_14970	ENOG4105E3W	Two component transcriptional regulator (Winged helix family
HZT40_14975	ENOG410804D	Sensor Signal Transduction Histidine Kinase
HZT40_15000	ENOG4105CEY	Amp-dependent synthetase and ligase
HZT40_15005	ENOG4105DPX	Hydrogenase, large subunit
HZT40_15025	ENOG4105E3S	small subunit
HZT40_15035	ENOG4108USZ	hydrogenase
HZT40_15065	ENOG4105XJC	Two component transcriptional regulator (Winged helix family
HZT40_15070	ENOG4105DHQ	Histidine kinase
HZT40_15105	ENOG4107R5M	Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity)
HZT40_15175	ENOG4105UHE	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity)
HZT40_15220	ENOG4107T8V	it plays a direct role in the translocation of protons across the membrane (By similarity)
HZT40_15230	ENOG4108Q71	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0) (By similarity)
HZT40_15235	ENOG4105CDG	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity)
HZT40_15240	ENOG4105J80	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity)
HZT40_15245	ENOG4105RX7	peptidase S8 and S53, subtilisin, kexin, sedolisin
HZT40_15250	ENOG4108RBJ	Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity)
HZT40_15285	ENOG4107QWP	ABC-2 type transporter
HZT40_15310	ENOG4105DR9	pseudouridine synthase
HZT40_15320	ENOG4105DKQ	ROK family
HZT40_15325	ENOG4105C1W	two component, sigma54 specific, transcriptional regulator, Fis family
HZT40_15330	ENOG4105K4H	Nlp p60 protein
HZT40_15350	ENOG4107Y3D	HAD-superfamily hydrolase subfamily IA variant 3
HZT40_15365	ENOG4107RK2	ADP-ribose diphosphatase NudE
HZT40_15370	ENOG4108RNI	3'(2')5'-bisphosphate nucleotidase
HZT40_15415	ENOG4105KNM	Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity)
HZT40_15420	ENOG4105C4J	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity)
HZT40_15425	ENOG4105J80	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity)
HZT40_15430	ENOG4105CDG	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity)
HZT40_15435	ENOG4107S15	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity)
HZT40_15440	ENOG4107Z6K	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity)
HZT40_15445	ENOG4105KY6	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity)
HZT40_15450	ENOG4105EE4	it plays a direct role in the translocation of protons across the membrane (By similarity)
HZT40_15465	ENOG4108NEV	two component transcriptional regulator, LytTR family
HZT40_15470	ENOG4108HRK	Histidine kinase
HZT40_15475	ENOG4105CH7	arginosuccinase
HZT40_15480	ENOG4105M02	This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity)
HZT40_15485	ENOG4105C07	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity)
HZT40_15495	ENOG4105DC6	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity)
HZT40_15500	ENOG4105DKX	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity)
HZT40_15505	ENOG4105KW8	RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity)
HZT40_15510	ENOG4105C1N	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity)
HZT40_15515	ENOG4105C4P	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity)
HZT40_15520	ENOG4105K63	Thioredoxin
HZT40_15550	ENOG4105ED0	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity)
HZT40_15555	ENOG4108ZI0	d,d-heptose 1,7-bisphosphate phosphatase
HZT40_15585	ENOG4105UYK	outer membrane protein a
HZT40_15620	ENOG4105CI3	gtp-binding protein typa
HZT40_15640	ENOG4107S78	Band 7 protein
HZT40_15675	ENOG4105C0G	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity)
HZT40_15705	ENOG4108IYS	Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity)
HZT40_15715	ENOG4105E4Z	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity)
HZT40_15720	ENOG41082K8	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Interacts with IscS and stimulates its activity. Then, accepts a sulfur from IscS and transfers it in turn to TusD (By similarity)
HZT40_15725	ENOG4107EEK	Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity)
HZT40_15730	ENOG4106NZV	Responsible for synthesis of pseudouridine from uracil- 13 in transfer RNAs (By similarity)
HZT40_15740	ENOG4105D3H	Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity)
HZT40_15750	ENOG4105C6P	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity)
HZT40_15805	ENOG4105C12	Phosphoribosylglycinamide synthetase
HZT40_15815	ENOG41070EG	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes (By similarity)
HZT40_15860	ENOG4105F5D	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity)
HZT40_15865	ENOG4106I92	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity)
HZT40_15870	ENOG4108J5C	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity)
HZT40_15900	ENOG4105EHZ	conserved protein UCP016719
HZT40_15910	ENOG4105C5R	Aminotransferase
HZT40_15915	ENOG4105CM0	Catalyzes the synthesis of GMP from XMP (By similarity)
HZT40_15930	ENOG4108R99	pseudouridine synthase
HZT40_15975	ENOG4105CB3	Required for the thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32) (By similarity)
HZT40_15980	ENOG4108IQF	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity)
HZT40_15995	ENOG4105EHM	Aminoglycoside phosphotransferase
HZT40_16000	ENOG4108S0S	Nucleotidyl transferase
HZT40_16005	ENOG4105EGS	Mechanosensitive ion channel
HZT40_16010	ENOG4108ZEY	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP) (By similarity)
HZT40_16015	ENOG4105DZA	Converts GTP to 7,8-dihydroneopterin triphosphate (By similarity)
HZT40_16035	ENOG4105F4C	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress (By similarity)
HZT40_16045	ENOG4105EV9	Alpha Beta Hydrolase
HZT40_16065	ENOG41080G2	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity)
HZT40_16070	ENOG4105CHT	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity)
HZT40_16075	ENOG4105C3P	Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity)
HZT40_16110	ENOG4108JJ7	ABC transporter
HZT40_16115	ENOG4105FE9	pseudouridine synthase
HZT40_16125	ENOG4108UHA	Essential for recycling GMP and indirectly, cGMP (By similarity)
HZT40_16130	ENOG4108RW0	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity)
HZT40_16135	ENOG4105N42	UPF0307 protein
HZT40_16145	ENOG4105VQD	rieske 2fe-2S domain-containing protein
HZT40_16150	ENOG4108XC3	NADH ubiquinone oxidoreductase
HZT40_16180	ENOG4105DDY	UPF0142 protein ycaO
HZT40_16195	ENOG4108556	Isoprenoid biosynthesis protein with amidotransferase-like domain
HZT40_16200	ENOG4105D7N	magnesium and cobalt transport protein CorA
HZT40_16215	ENOG4105P8F	nudix hydrolase
HZT40_16220	ENOG4105ETT	transcriptional Regulator, LysR family
HZT40_16235	ENOG4105C3B	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity)
HZT40_16295	ENOG4105D0T	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity)
HZT40_16305	ENOG4107QHU	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity)
HZT40_16310	ENOG4105CHV	Transcription elongation factor NusA
HZT40_16315	ENOG4105K7D	Required for maturation of 30S ribosomal subunits (By similarity)
HZT40_16330	ENOG4105CNR	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
HZT40_16340	ENOG4105D65	subunit l
HZT40_16345	ENOG4105M5H	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
HZT40_16350	ENOG4105DF2	NADH dehydrogenase subunit j
HZT40_16355	ENOG41081XG	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
HZT40_16365	ENOG4108IEH	NADH dehydrogenase subunit g
HZT40_16370	ENOG4107QIZ	NADH dehydrogenase
HZT40_16380	ENOG4105CQV	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
HZT40_16385	ENOG4105CYU	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
HZT40_16410	ENOG4105CP7	Triose-phosphate isomerase
HZT40_16420	ENOG4105EEI	dihydropteroate synthase
HZT40_16425	ENOG4105C3H	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity)
HZT40_16435	ENOG4105HBR	Rna-binding protein
HZT40_16455	ENOG4105QA4	4Fe-4S Ferredoxin, iron-sulfur binding domain protein
HZT40_16465	ENOG4105BZ8	glutamate synthase
HZT40_16480	ENOG4108Z0T	Part of a sulfur-relay system (By similarity)
HZT40_16485	ENOG4105YKK	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions (By similarity)
HZT40_16490	ENOG4108ZKU	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions (By similarity)
HZT40_16495	ENOG4108ZAT	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE (By similarity)
HZT40_16500	ENOG4105PJW	Sulfite reductase dissimilatory-type beta subunit
HZT40_16505	ENOG4105CY1	sulfite reductase, dissimilatory-type alpha subunit
HZT40_16560	ENOG4105KWW	Biogenesis protein
HZT40_16565	ENOG4107QX9	Thiol disulfide interChange protein
HZT40_16580	ENOG41060IM	Heme exporter protein
HZT40_16585	ENOG4105CA5	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes (By similarity)
HZT40_16590	ENOG4106WTF	Glycosyl transferase, family 2
HZT40_16625	ENOG4107E2E	PKHD-type hydroxylase
HZT40_16650	ENOG4105CQ7	ATP-dependent helicase
HZT40_16660	ENOG4105D94	Major Facilitator Superfamily
HZT40_16665	ENOG4105C5Q	Transcriptional regulator
HZT40_16685	ENOG4105EAK	ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family
HZT40_16700	ENOG4105DI7	Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity)
HZT40_16710	ENOG4105CM3	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity)
HZT40_16730	ENOG4105CQI	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity)
HZT40_16735	ENOG4108MP6	LysR family Transcriptional regulator
HZT40_16840	ENOG4107YU2	histidine triad (hIT) protein
HZT40_16860	ENOG4105F3K	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity)
HZT40_16865	ENOG4105KDX	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity)
HZT40_16880	ENOG4105DPZ	Two component transcriptional regulator (Winged helix family
HZT40_16900	ENOG4105CK6	Two component transcriptional regulator (Winged helix family
HZT40_16925	ENOG4105IES	Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity)
HZT40_16930	ENOG4105GJM	(LipO)protein
HZT40_16935	ENOG4105CDP	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity)
HZT40_16940	ENOG4108IAB	Phoh family
HZT40_16945	ENOG4107T5V	SNARE associated Golgi
HZT40_17045	ENOG4107WDG	serine threonine protein kinase
HZT40_17060	ENOG4105CC0	LysR family Transcriptional regulator
HZT40_17070	ENOG4105DS1	cytochrome b561
HZT40_17090	ENOG4105CGK	Exodeoxyribonuclease III
HZT40_17095	ENOG4105DBV	ornithine carbamoyltransferase
HZT40_17100	ENOG4105C8Y	Acetylornithine aminotransferase
HZT40_17105	ENOG4105CJ2	(LipO)protein
HZT40_17140	ENOG4105BZS	acriflavin resistance protein
HZT40_17150	ENOG4108WWZ	General secretion pathway protein J
HZT40_17175	ENOG4105MJ2	Competence protein
HZT40_17180	ENOG4105DSJ	YicC domain protein
HZT40_17195	ENOG4105C0H	protease
HZT40_17200	ENOG4105WHM	Necessary for normal cell division and for the maintenance of normal septation (By similarity)
HZT40_17210	ENOG4105EBH	Required during biogenesis of c-type cytochromes (cytochrome c6 and cytochrome f) at the step of heme attachment (By similarity)
HZT40_17220	ENOG4108Z33	Thiol disulfide Interchange Protein
HZT40_17225	ENOG4108S0N	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol (By similarity)
HZT40_17230	ENOG4108BDP	Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity)
HZT40_17235	ENOG4108Z43	UPF0250 protein
HZT40_17240	ENOG4105DZ1	carboxypeptidase
HZT40_17245	ENOG4105K6T	rare lipoprotein A
HZT40_17250	ENOG4105CVE	Lytic murein transglycosylase
HZT40_17255	ENOG4105CNI	cell division protein FtsW
HZT40_17265	ENOG4105F0N	pyrophosphate phospho-hydrolase
HZT40_17275	ENOG4105CU0	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity)
HZT40_17280	ENOG4105EAY	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
HZT40_17290	ENOG41082RQ	UPF0102 protein
HZT40_17295	ENOG4105F55	Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate (By similarity)
HZT40_17300	ENOG4107QZM	n-acetylglutamate synthase
HZT40_17310	ENOG4105EYM	Major Facilitator superfamily
HZT40_17350	ENOG4105VNB	Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity)
HZT40_17365	ENOG4108HGY	Proline imino-peptidase
HZT40_17370	ENOG4105CSR	polyphosphate kinase 2
HZT40_17390	ENOG4105VEJ	Heat shock protein
HZT40_17395	ENOG4108ZZ3	UPF0260 protein
HZT40_17410	ENOG4107R11	Transcriptional regulator
HZT40_17415	ENOG4107RIQ	Sulfate adenylate transferase
HZT40_17420	ENOG4108DNJ	Pfam:TonB
HZT40_17425	ENOG4105M15	transport protein ExbD
HZT40_17430	ENOG4105M8K	biopolymer transport protein
HZT40_17440	ENOG4105MRR	Transcriptional regulator (By similarity)
HZT40_17450	ENOG4105CA0	peroxidase
HZT40_17470	ENOG4105BZU	Histidine kinase
HZT40_17475	ENOG4107QP3	malate synthase g
HZT40_17500	ENOG4107MKT	Stringent starvation protein a
HZT40_17515	ENOG4105C9X	ppx gppa phosphatase
HZT40_17525	ENOG4105CWR	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity)
HZT40_17530	ENOG4105VFG	Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity)
HZT40_17535	ENOG4105DE5	Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity)
HZT40_17540	ENOG41080XP	Cbs domain
HZT40_17550	ENOG4105XA0	heptosyltransferase ii
HZT40_17560	ENOG4105CM2	brancheD-chain amino acid aminotransferase
HZT40_17565	ENOG4105E4C	Lytic transglycosylase catalytic
HZT40_17570	ENOG4105NWN	ApaG protein
HZT40_17575	ENOG4105CGT	Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity)
HZT40_17595	ENOG4105EAH	synthase
HZT40_17605	ENOG4105BZU	Histidine kinase
HZT40_17625	ENOG4108RAC	Rubrerythrin
HZT40_17640	ENOG4105K4H	Nlp p60 protein
HZT40_17645	ENOG4105FDS	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity)
HZT40_17650	ENOG4108UKZ	OsmC family
HZT40_17655	ENOG4105Z2P	Protein of unknown function (DUF465)
HZT40_17660	ENOG4105D7Z	glutathione synthase
HZT40_17665	ENOG4105CSF	NADPH-dependent glycerol-3-phosphate dehydrogenase
HZT40_17670	ENOG4105IX2	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA (By similarity)
HZT40_17680	ENOG4105C72	UPF0176 protein
HZT40_17695	ENOG4105CN1	protease
HZT40_17705	ENOG4108YXW	Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity)
HZT40_17710	ENOG4108ZAF	Molybdopterin
HZT40_17715	ENOG4105M00	molybdopterin converting factor, subunit 1
HZT40_17725	ENOG4105C46	Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity)
HZT40_17730	ENOG4105CAJ	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity)
HZT40_17745	ENOG4107QY0	Catalyzes the dehydration of methylthioribulose-1- phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1- phosphate (DK-MTP-1-P) (By similarity)
HZT40_17770	ENOG4105E05	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity)
HZT40_17775	ENOG4105BZH	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity)
HZT40_17810	ENOG4105CKW	Inner membrane protein yedI
HZT40_17815	ENOG4105F8C	transglutaminase domain-containing protein
HZT40_17825	ENOG4105C7R	Atpase associated with various cellular activities aaa_3
HZT40_17830	ENOG4108RBP	3'-to-5' exoribonuclease specific for small oligoribonucleotides (By similarity)
HZT40_17840	ENOG4105E06	May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity)
HZT40_17850	ENOG4107SC1	transglycosylase
HZT40_17855	ENOG4108RTD	type II secretion system protein K
HZT40_17865	ENOG4108BY5	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins (By similarity)
HZT40_17885	ENOG4105BZU	Histidine kinase
HZT40_17905	ENOG4105CCT	upf0313 protein
HZT40_17985	ENOG4107S1Q	Phosphatase
HZT40_17990	ENOG4108UMS	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase (By similarity)
HZT40_18025	ENOG4105CSR	polyphosphate kinase 2
HZT40_18030	ENOG4105E4C	Lytic transglycosylase catalytic
HZT40_18060	ENOG4108HMN	Caspase domain
HZT40_18100	ENOG4107QX8	SPFH domain, Band 7 family protein
HZT40_18110	ENOG4105D0I	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity)
HZT40_18150	ENOG4105D95	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin (By similarity)
HZT40_18165	ENOG4107QN2	dihydrolipoyl dehydrogenase
HZT40_18170	ENOG4107QSN	dihydrolipoamide acetyltransferase
HZT40_18175	ENOG4105DAQ	Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity)
HZT40_18185	ENOG4105DAA	L-lactate
HZT40_18210	ENOG4105BZU	Histidine kinase
HZT40_18225	ENOG4105CE6	Adenylation and deadenylation of glutamate--ammonia ligase (By similarity)
HZT40_18240	ENOG4105DFP	Integrase
HZT40_18360	ENOG4105FQ6	thiopurine methyltransferase
HZT40_18365	ENOG4105D9I	Responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6 (By similarity)
HZT40_18430	ENOG4107VBM	3-beta hydroxysteroid dehydrogenase isomerase
HZT40_18435	ENOG4105CCZ	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity)
HZT40_18505	ENOG410756H	nucleotidyltransferase
HZT40_18525	ENOG4105XMH	SpoVT AbrB domain protein
HZT40_18530	ENOG4105M0J	Toxic component of a toxin-antitoxin (TA) module. A
HZT40_18540	ENOG4108UMS	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase (By similarity)
HZT40_18580	ENOG4106D4I	domain protein
HZT40_18585	ENOG4107VRP	DNA repair exonuclease
HZT40_18590	ENOG4105ETT	transcriptional Regulator, LysR family
HZT40_18595	ENOG4108IPJ	Membrane
HZT40_18600	ENOG4105R1U	AraC Family Transcriptional Regulator
HZT40_18620	ENOG4105EEX	Two component transcriptional regulator (Winged helix family
HZT40_18625	ENOG4105C08	Histidine kinase
HZT40_18670	ENOG4105EKE	dihydroorotase
HZT40_18695	ENOG4105DTN	riboflavin biosynthesis protein ribF
HZT40_18705	ENOG4105D16	lipopolysaccharide heptosyltransferase i
HZT40_18730	ENOG4105DS7	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity)
HZT40_18735	ENOG4105CV9	cyclopropane-fatty-acyl-phospholipid synthase
HZT40_18745	ENOG4105C1H	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity)
HZT40_18750	ENOG4105DHW	Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins
HZT40_18755	ENOG4105NVJ	RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity)
HZT40_18760	ENOG4105VG0	50S ribosomal protein l34
HZT40_18775	ENOG4105C3X	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity)
HZT40_18780	ENOG4105C3X	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity)
HZT40_18785	ENOG4105C7D	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
HZT40_18795	ENOG4105CGK	Exodeoxyribonuclease III
HZT40_18810	ENOG4105D78	K07001 NTE family protein
HZT40_18830	ENOG4105D6W	Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity)
HZT40_18835	ENOG41076E6	Uroporphyrinogen-III Synthase
HZT40_18855	ENOG4105C6K	Malic enzyme
HZT40_18860	ENOG4105ERG	peptidase m48, ste24p
HZT40_18875	ENOG4108RKI	Necessary for the introduction of cis unsaturation into fatty acids. Catalyzes the dehydration of (3R)-3-hydroxydecanoyl- ACP to E-(2)-decenoyl-ACP and then its isomerization to Z-(3)- decenoyl-ACP. Can catalyze the dehydratase reaction for beta- hydroxyacyl-ACPs with saturated chain lengths up to 16 0, being most active on intermediate chain length (By similarity)
HZT40_18880	ENOG4105C4G	Synthesis of 3-octaprenyl-4-hydroxybenzoate (By similarity)
HZT40_18920	ENOG4107RHT	methyl-accepting chemotaxis sensory transducer with Pas Pac sensor
HZT40_18950	ENOG4105EYA	deoxyribonuclease
HZT40_18955	ENOG41070EG	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes (By similarity)
HZT40_18960	ENOG4105CHI	Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB (By similarity)
HZT40_18975	ENOG4105FBT	Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs (By similarity)
HZT40_18980	ENOG41068B1	Cob-I-yrinic acid a,c-diamide adenosyltransferase
HZT40_19000	ENOG4105GN9	Joins Ado-cobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin) (By similarity)
HZT40_19005	ENOG4108TGR	phosphatase
HZT40_19010	ENOG4105CUP	Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB) (By similarity)
HZT40_19015	ENOG4108YZT	Adenosylcobinamide kinase
HZT40_19020	ENOG4108UK1	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant (By similarity)
HZT40_19030	ENOG4108UJU	UPF0301 protein
HZT40_19050	ENOG4105CWR	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity)
HZT40_19065	ENOG4105C8V	SAICAR synthetase
HZT40_19075	ENOG4105CY8	phosphoribosylaminoimidazole carboxylase atpase subunit
HZT40_19085	ENOG4107Y49	methyltransferase
HZT40_19090	ENOG4105WVZ	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity)
HZT40_19105	ENOG4105DBS	Key enzyme in heme biosynthesis. Catalyzes the oxidative decarboxylation of propionic acid side chains of rings A and B of coproporphyrinogen III (By similarity)
HZT40_19120	ENOG4105C5X	domain protein
HZT40_19125	ENOG4105C5H	ABC transporter
HZT40_19135	ENOG4107SVV	electron transport complex, RnfABCDGE type, B subunit
HZT40_19145	ENOG4107QTR	Required for nitrogen fixation. May be part of a membrane complex functioning as an intermediate in the electron transport to nitrogenase (By similarity)
HZT40_19150	ENOG4105D6A	Electron transport complex
HZT40_19160	ENOG4105DZB	Electron transport complex
HZT40_19165	ENOG4105DGN	Electron transport complex
HZT40_19210	ENOG4108UJE	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity)
HZT40_19215	ENOG4105ECC	imidazole-glycerol-phosphate dehydratase
HZT40_19220	ENOG4105HF0	Membrane
HZT40_19225	ENOG4105ZIE	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides (By similarity)
HZT40_19260	ENOG4105C5H	ABC transporter
HZT40_19265	ENOG4106371	Methyltransferase
HZT40_19280	ENOG4105E0Y	RtcB Protein
HZT40_19285	ENOG4105G2Y	Transcriptional regulator
HZT40_19295	ENOG4105DR4	Methyltransferase
HZT40_19340	ENOG4105QA4	4Fe-4S Ferredoxin, iron-sulfur binding domain protein
HZT40_19345	ENOG4108KDI	dmso reductase anchor subunit
HZT40_19355	ENOG4108IQK	o-acetylhomoserine
HZT40_19370	ENOG4105EEF	Alkane 1-monooxygenase
HZT40_19375	ENOG4105VAS	Could be involved in insertion of integral membrane proteins into the membrane (By similarity)
HZT40_19385	ENOG4105K8F	Phosphoribosyl-amp cyclohydrolase
HZT40_19395	ENOG4105C4N	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis (By similarity)
HZT40_19400	ENOG4108R5P	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery (By similarity)
HZT40_19405	ENOG4108Z5K	methylglyoxal synthase
HZT40_19420	ENOG4105IES	Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity)
HZT40_19430	ENOG4105E0F	Histidine kinase
HZT40_19435	ENOG4105C0H	protease
HZT40_19440	ENOG4105D8C	Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity)
HZT40_19455	ENOG41067MG	lrgb family
HZT40_19490	ENOG4105MPD	Cytochrome
HZT40_19600	ENOG4105BZ1	(ABC) transporter
HZT40_19625	ENOG4105CNA	YD repeat protein
HZT40_19700	ENOG4105CNA	YD repeat protein
HZT40_19765	ENOG4105C4R	Atp-dependent dna helicase
HZT40_19770	ENOG4105C3J	Cysteine desulfurase
HZT40_19795	ENOG4105CCX	Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity)
HZT40_19800	ENOG4108RPN	Protein smg homolog
HZT40_19805	ENOG4105C79	DNA protecting protein DprA
HZT40_19815	ENOG4108Z02	Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity)
HZT40_19820	ENOG4105CYJ	ribosomal RNA small subunit methyltransferase B
HZT40_19830	ENOG4105ES5	Histidine kinase
HZT40_19835	ENOG4105C1W	two component, sigma54 specific, transcriptional regulator, Fis family
HZT40_19840	ENOG4105C1A	potassium transporter peripheral membrane
HZT40_19845	ENOG4105D37	Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA (By similarity)
HZT40_19860	ENOG4107QP8	phosphohexose isomerase
HZT40_19865	ENOG4105CHC	glucokinase (EC 2.7.1.2)
HZT40_19885	ENOG4105C9C	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity)
HZT40_19890	ENOG4105CXW	Synthesizes alpha-1,4-glucan chains using ADP-glucose (By similarity)
HZT40_19900	ENOG4105C48	Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity)
HZT40_19910	ENOG4105CD3	dihydroorotase
HZT40_19920	ENOG4105D3Q	Sugar transferase
HZT40_19925	ENOG4108R5S	membrane
HZT40_19935	ENOG4107RRE	RNA-directed DNA polymerase
HZT40_19975	ENOG4108DN8	FAD dependent oxidoreductase
HZT40_19985	ENOG4105CMQ	Chloride channel
HZT40_20015	ENOG4105C01	Dihydroxy-acid dehydratase
HZT40_20020	ENOG4105C2M	dna polymerase I
HZT40_20030	ENOG4105CQZ	Histidine kinase
HZT40_20050	ENOG4107RVU	D-Ala-D-Ala carboxypeptidase 3 (S13) family
HZT40_20055	ENOG4105CBM	Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 (By similarity)
HZT40_20070	ENOG4108EX3	reductase
HZT40_20075	ENOG4108HH9	Catalyzes two reactions the first one is the production of beta-formyl glycinamide ribonucleotide (GAR) from formate, ATP and beta GAR
HZT40_20095	ENOG4105C4R	Atp-dependent dna helicase
HZT40_20130	ENOG4105CJV	Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase
HZT40_20140	ENOG4105C0S	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity)
HZT40_20160	ENOG4105WKS	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity)
HZT40_20165	ENOG4105X8U	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation (By similarity)
HZT40_20180	ENOG4105CJI	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity)
HZT40_20200	ENOG4105CA8	Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity)
HZT40_20205	ENOG4105CZ1	Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity)
HZT40_20210	ENOG4105C6K	Malic enzyme
HZT40_20220	ENOG4105CV2	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates (By similarity)
HZT40_20230	ENOG4105DR6	Trap dicarboxylate transporter, dctp subunit
HZT40_20240	ENOG4105CG6	trap dicarboxylate transporter dctm subunit
HZT40_20250	ENOG4105VCQ	rubredoxin
HZT40_20270	ENOG4105ERH	Fumarylacetoacetate hydrolase
HZT40_20275	ENOG4105C0P	Mg chelatase subunit ChlI
HZT40_20350	ENOG4108ZF3	Phosphatase
HZT40_20390	ENOG4105C2Z	ATP-dependent CLP protease ATP-binding subunit
HZT40_20435	ENOG4108WC9	type VI secretion system effector, hcp1 family
HZT40_20475	ENOG4107RIQ	Sulfate adenylate transferase
HZT40_20485	ENOG4107QRH	Arylsulfatase (Ec 3.1.6.1)
HZT40_20490	ENOG4105C4X	radical SAM domain protein
HZT40_20535	ENOG4105C0W	non-ribosomal peptide synthetase
HZT40_20545	ENOG4105CSA	Coproporphyrinogen iii oxidase
HZT40_20550	ENOG4107P5I	polyketide synthase
HZT40_20560	ENOG4105C7K	acetolactate synthase
HZT40_20575	ENOG4105CYQ	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity)
HZT40_20580	ENOG4105MQS	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity)
HZT40_20590	ENOG4105CQI	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity)
HZT40_20595	ENOG4105C0C	Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity)
HZT40_20600	ENOG4105CHM	Aminotransferase
HZT40_20630	ENOG4105DDW	LysR family Transcriptional regulator
HZT40_20635	ENOG4105CK6	Two component transcriptional regulator (Winged helix family
HZT40_20690	ENOG4105IBP	Cyclic peptide transporter
HZT40_20725	ENOG4107RUE	extracellular solute-binding protein family 1
HZT40_20730	ENOG4105DFA	alanine racemase domain protein
HZT40_20735	ENOG4105CZX	twitching motility protein
HZT40_20740	ENOG4105CZX	twitching motility protein
HZT40_20760	ENOG4105E78	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity)
HZT40_20770	ENOG4105C8S	subunit m
HZT40_20775	ENOG4105C8S	subunit m
HZT40_20785	ENOG4105EVH	UPF0753 protein
HZT40_20795	ENOG4105C8S	subunit m
HZT40_20810	ENOG4105BZU	Histidine kinase
HZT40_20945	ENOG4105E06	May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity)
HZT40_20965	ENOG4108U78	Glutathione S-transferase
HZT40_20995	ENOG41080E2	ribosomal-protein-alanine acetyltransferase
HZT40_21000	ENOG4108VXP	Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity)
HZT40_21035	ENOG4105CYQ	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity)
HZT40_21050	ENOG4105J0Q	Transcriptional regulator
HZT40_21065	ENOG4105C3B	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity)
HZT40_21090	ENOG4105CF1	Alkylated DNA repair protein
HZT40_21095	ENOG4105EUJ	GTP cyclohydrolase i
HZT40_21100	ENOG4105K85	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity)
HZT40_21120	ENOG4105E0Y	RtcB Protein
HZT40_21140	ENOG4105CYB	regulatoR
HZT40_21150	ENOG4105C4H	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity)
HZT40_21170	ENOG4105F8V	Hydrolase, tatD family
HZT40_21185	ENOG4105D9M	gamma-glutamylcysteine synthetase
HZT40_21190	ENOG4105VFU	Rna-binding protein
HZT40_21195	ENOG4105VZ9	UPF0235 protein
HZT40_21200	ENOG4108VIA	integral membrane protein
HZT40_21205	ENOG4105II7	pyrroline-5-carboxylate reductase
HZT40_21220	ENOG4105CFP	Peptidase U32
HZT40_21235	ENOG4107RIQ	Sulfate adenylate transferase
HZT40_21250	ENOG4105CC8	Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity)
HZT40_21255	ENOG4108YZY	peptidylprolyl cis-trans isomerase
HZT40_21265	ENOG4107R15	K00850 6-phosphofructokinase 1 EC 2.7.1.11
HZT40_21285	ENOG4107RNU	major facilitator superfamily MFS_1
HZT40_21295	ENOG4108IFG	nitrite reductase, (NAD(P)H)
HZT40_21370	ENOG4105CK0	Membrane bOund o-acyl transferase mboat family protein
HZT40_21385	ENOG41086B8	CoB-CoM heterodisulfide reductase
HZT40_21400	ENOG4105EWK	phytoene
HZT40_21410	ENOG4105CD5	CoA-binding domain protein
HZT40_21415	ENOG4105DWF	phosphomethylpyrimidine kinase
HZT40_21430	ENOG4105CDM	Glutamate-1-semialdehyde aminotransferase
HZT40_21450	ENOG4105QF0	Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity)
HZT40_21465	ENOG4107QX8	SPFH domain, Band 7 family protein
HZT40_21480	ENOG4105E3W	Two component transcriptional regulator (Winged helix family
HZT40_21485	ENOG4105CM1	Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity)
HZT40_21495	ENOG4105D3Z	quinone oxidoreductase, yhdh yhfp family
HZT40_21500	ENOG4105EXC	Acyl-transferase
HZT40_21505	ENOG4105C6U	Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity)
HZT40_21540	ENOG4105DR1	Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity)
HZT40_21545	ENOG4105K8N	protein family UPF0079, ATPase
HZT40_21550	ENOG4105C5C	n-acetylmuramoyl-l-alanine amidase
HZT40_21560	ENOG4105EK0	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity)
HZT40_21570	ENOG4108ZCA	Inherit from COG: pyridine nucleotide-disulfide oxidoreductase
HZT40_21580	ENOG4108WUH	Transcriptional regulator, TetR family
HZT40_21590	ENOG4105C1I	TRANSCRIPTIONAl REGULATOR GntR family
HZT40_21595	ENOG4105EMU	Dehydrogenase
HZT40_21600	ENOG4105CR8	Transcriptional regulator
HZT40_21605	ENOG4105CM2	brancheD-chain amino acid aminotransferase
HZT40_21625	ENOG4105I8F	Histidine kinase
HZT40_21630	ENOG4105BZU	Histidine kinase
HZT40_21640	ENOG4105C8Y	Acetylornithine aminotransferase
HZT40_21645	ENOG4108MUX	N-hydroxyarylamine O-acetyltransferase
HZT40_21655	ENOG4105DFG	type I secretion outer membrane protein
HZT40_21665	ENOG4105E26	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity)
HZT40_21710	ENOG4105QN4	diheme cytochrome
HZT40_21735	ENOG4105ERG	peptidase m48, ste24p
HZT40_21740	ENOG41082J7	Rhodanese domain protein
HZT40_21745	ENOG4108ZCA	Inherit from COG: pyridine nucleotide-disulfide oxidoreductase
HZT40_21760	ENOG4108UNF	response regulator
HZT40_21775	ENOG4105C8Q	Methyl-accepting chemotaxis
HZT40_21810	ENOG4105CBS	Chea signal transduction histidine kinase
HZT40_21815	ENOG4108UNF	response regulator
HZT40_21830	ENOG4105DDT	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity)
HZT40_21840	ENOG4105C25	Primosomal protein n'
HZT40_21845	ENOG4105C15	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity)
HZT40_21850	ENOG4105W8H	transhydrogenase (subunit alpha
HZT40_21855	ENOG4108IIE	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity)
HZT40_21860	ENOG4105UYK	outer membrane protein a
HZT40_21870	ENOG4105DXN	mazG family
HZT40_21885	ENOG4105NHU	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group (By similarity)
HZT40_21890	ENOG4105CDY	transcriptional regulatory protein
HZT40_21895	ENOG4105C6R	Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity)
HZT40_21920	ENOG4105CAJ	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity)
HZT40_21925	ENOG4107XAN	XdhC and CoxI family
HZT40_21960	ENOG4105D06	uba thif-type nad fad binding protein
HZT40_21970	ENOG410635M	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein (By similarity)
HZT40_21990	ENOG4105HP8	regulator of competence-specific genes
HZT40_22010	ENOG4105HP8	regulator of competence-specific genes
HZT40_22015	ENOG4105CNG	UPF0061 protein
HZT40_22035	ENOG4105JIE	May be involved in the transport of PQQ or its precursor to the periplasm (By similarity)
HZT40_22055	ENOG41086XE	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ (By similarity)
HZT40_22060	ENOG4105WF7	pyrroloquinoline quinone biosynthesis protein d
HZT40_22065	ENOG4105EZY	Pyrroloquinoline quinone biosynthesis protein E
HZT40_22070	ENOG4105DZG	Dehydrogenase
HZT40_22080	ENOG4105EAB	amino acid AbC transporter
HZT40_22140	ENOG4105C1X	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity (By similarity)
HZT40_22170	ENOG4105CJ1	ABC, transporter
HZT40_22200	ENOG4105D2N	Aldolase
HZT40_22205	ENOG4105CA9	Pyruvate kinase
HZT40_22210	ENOG4105BZA	Phosphoglycerate kinase
HZT40_22215	ENOG4105C17	glyceraldehyde-3-phosphate dehydrogenase
HZT40_22220	ENOG4105CV1	Transketolase (EC 2.2.1.1)
HZT40_22225	ENOG4105CPH	Catalyzes the formation of S-adenosylmethionine from methionine and ATP
HZT40_22240	ENOG4105SYT	Methylenetetrahydrofolate reductase
HZT40_22260	ENOG4105EEQ	Na H antiporter
HZT40_22265	ENOG4105CKF	membrane protein involved in aromatic hydrocarbon degradation
HZT40_22280	ENOG4105CVR	type I restriction-modification system
HZT40_22285	ENOG4105CB5	ATP-dependent DNA helicase recG
HZT40_22300	ENOG4105EKX	Restriction modification system DNA (Specificity
HZT40_22305	ENOG4107R3N	Filamentation induced by cAMP protein fic
HZT40_22330	ENOG4105DZR	Type I site-specific deoxyribonuclease
HZT40_22335	ENOG4105CBX	hi0933 family
HZT40_22565	ENOG4105KCK	Peptidoglycan-associated lipoprotein
HZT40_22590	ENOG4105M8F	Biopolymer transport protein exbD tolR
HZT40_22595	ENOG4105E02	MotA TolQ exbB proton channel
HZT40_22605	ENOG4105CKJ	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity)
HZT40_22610	ENOG4105ESV	Glycosyl transferase, family 4
HZT40_22615	ENOG4105CF4	DegT DnrJ EryC1 StrS aminotransferase
HZT40_22620	ENOG4108MX3	Polysaccharide Biosynthesis Protein
HZT40_22650	ENOG4105ECJ	Glycosyl Transferase
HZT40_22655	ENOG4105C0K	Gdp-mannose 4,6-dehydratase
HZT40_22660	ENOG4105C30	Nad-dependent epimerase dehydratase
HZT40_22665	ENOG4105CJT	Mannose-1-phosphate guanylyltransferase
HZT40_22705	ENOG4105CM3	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity)
HZT40_22715	ENOG4105CJ1	ABC, transporter
HZT40_22755	ENOG4105C5H	ABC transporter
HZT40_22760	ENOG4105C2M	dna polymerase I
HZT40_22770	ENOG4105KMG	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes (By similarity)
HZT40_22775	ENOG4105CEN	a g-specific adenine glycosylase
HZT40_22785	ENOG4105EAM	Na Pi-cotransporter
HZT40_22800	ENOG4107QN1	sodium solute
HZT40_22815	ENOG4105C1W	two component, sigma54 specific, transcriptional regulator, Fis family
HZT40_22835	ENOG4105C5F	glutamine synthetase
HZT40_22850	ENOG4105CUV	Homoserine Kinase
HZT40_22865	ENOG4105VFK	BolA family
HZT40_22910	ENOG4105D00	flagellar biosynthetic protein flhB
HZT40_22920	ENOG41083GP	type iii secretion
HZT40_22960	ENOG4107Y59	type iii secretion
HZT40_22965	ENOG4105D1S	lipid A biosynthesis
HZT40_22980	ENOG4105ECY	inositol monophosphatase
HZT40_22985	ENOG4105F03	Provides the (R)-glutamate required for cell wall biosynthesis (By similarity)
HZT40_23005	ENOG4105ERD	Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity)
HZT40_23015	ENOG4105CEH	Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity)
HZT40_23035	ENOG4105NAU	thioesterase Superfamily protein
HZT40_23050	ENOG4105C75	arginyL-tRNA synthetase
HZT40_23110	ENOG4105CZX	twitching motility protein
HZT40_23115	ENOG4105I08	Pseudouridine synthase
HZT40_23120	ENOG4105C7B	Threonine dehydratase