locus-tag	class	description
HZT40_00035	COG0018	arginyl-trna synthetase
HZT40_00110	COG1187	pseudouridine synthase activity
HZT40_00115	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HZT40_00120	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
HZT40_00160	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
HZT40_00245	COG0617	tRNA 3'-terminal CCA addition
HZT40_00250	COG0446	pyridine nucleotide-disulphide oxidoreductase
HZT40_00270	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
HZT40_00275	COG1121	(ABC) transporter
HZT40_00285	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
HZT40_00290	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
HZT40_00300	COG1720	tRNA m6t6A37 methyltransferase activity
HZT40_00305	COG2027	D-alanyl-D-alanine carboxypeptidase
HZT40_00320	COG2911	Protein conserved in bacteria
HZT40_00340	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
HZT40_00365	COG0081	regulation of translation
HZT40_00370	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
HZT40_00375	COG0222	ribosome binding
HZT40_00395	COG0049	tRNA binding
HZT40_00400	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HZT40_00405	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
HZT40_00410	COG0051	transcription antitermination factor activity, RNA binding
HZT40_00415	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
HZT40_00420	COG0088	Forms part of the polypeptide exit tunnel
HZT40_00425	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
HZT40_00430	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
HZT40_00435	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
HZT40_00445	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
HZT40_00450	COG0255	Belongs to the universal ribosomal protein uL29 family
HZT40_00455	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
HZT40_00470	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
HZT40_00475	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
HZT40_00485	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
HZT40_00495	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
HZT40_00500	COG1841	ribosomal large subunit assembly
HZT40_00505	COG0200	Binds to the 23S rRNA
HZT40_00510	COG0201	protein transport
HZT40_00515	COG0257	Belongs to the bacterial ribosomal protein bL36 family
HZT40_00520	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
HZT40_00525	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
HZT40_00530	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
HZT40_00535	COG0202	RNA polymerase activity
HZT40_00550	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
HZT40_00555	COG0445	tRNA wobble uridine modification
HZT40_00565	COG1192	Involved in chromosome partitioning
HZT40_00570	COG1475	DNA binding
HZT40_00575	COG0268	Binds directly to 16S ribosomal RNA
HZT40_00580	COG0237	dephospho-CoA kinase activity
HZT40_00585	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
HZT40_00605	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
HZT40_00660	COG2217	Heavy metal translocating P-type atpase
HZT40_00665	COG0542	response to heat
HZT40_00695	COG1028	Short-chain dehydrogenase reductase Sdr
HZT40_00700	COG1022	Amp-dependent synthetase and ligase
HZT40_00735	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HZT40_00740	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HZT40_00755	COG0784	Response regulator, receiver
HZT40_00755	COG2205	protein histidine kinase activity
HZT40_00755	COG5002	protein histidine kinase activity
HZT40_00765	COG3166	PFAM Fimbrial assembly family protein
HZT40_00780	COG1450	Type ii and iii secretion system protein
HZT40_00820	COG1215	transferase activity, transferring glycosyl groups
HZT40_00840	COG1216	Glycosyl transferase, family 2
HZT40_00850	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
HZT40_00855	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
HZT40_00880	COG0004	ammonium transporteR
HZT40_00905	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
HZT40_00915	COG1560	Kdo2-lipid A biosynthetic process
HZT40_00925	COG0443	Heat shock 70 kDa protein
HZT40_00930	COG2214	Heat shock protein DnaJ domain protein
HZT40_00945	COG0667	Aldo Keto reductase
HZT40_00950	COG1519	Transferase
HZT40_01035	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
HZT40_01045	COG4953	penicillin-binding protein 1C
HZT40_01055	COG0135	phosphoribosylanthranilate isomerase activity
HZT40_01095	COG0285	dihydrofolate synthase activity
HZT40_01120	COG1376	ErfK ybiS ycfS ynhG family protein
HZT40_01140	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
HZT40_01145	COG1610	YqeY-like protein
HZT40_01155	COG0735	belongs to the Fur family
HZT40_01160	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HZT40_01175	COG2867	negative regulation of translational initiation
HZT40_01190	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HZT40_01205	COG1199	ATP-dependent helicase activity
HZT40_01215	COG0367	asparagine synthase
HZT40_01270	COG0745	RESPONSE REGULATOR receiver
HZT40_01275	COG2197	response regulator
HZT40_01285	COG2197	response regulator
HZT40_01345	COG2319	Wd-40 repeat
HZT40_01345	COG4249	Peptidase C14 caspase catalytic subunit p20
HZT40_01415	COG1999	signal sequence binding
HZT40_01420	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
HZT40_01425	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
HZT40_01430	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
HZT40_01460	COG1222	aaa ATPase
HZT40_01590	COG2943	transferase activity, transferring hexosyl groups
HZT40_01600	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
HZT40_01630	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HZT40_01635	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
HZT40_01670	COG1696	Membrane protein involved in D-alanine export
HZT40_01680	COG0463	Glycosyl transferase, family 2
HZT40_01700	COG0438	transferase activity, transferring glycosyl groups
HZT40_01705	COG0463	Glycosyl transferase, family 2
HZT40_01725	COG4636	protein conserved in cyanobacteria
HZT40_01740	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HZT40_01740	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
HZT40_01755	COG1968	undecaprenyl-diphosphatase activity
HZT40_01865	COG1573	uracil-dna glycosylase
HZT40_01885	COG4636	protein conserved in cyanobacteria
HZT40_01890	COG3344	reverse transcriptase
HZT40_01895	COG1518	maintenance of DNA repeat elements
HZT40_01955	COG1337	RAMP superfamily
HZT40_01965	COG1353	crispr-associated protein
HZT40_01990	COG4636	protein conserved in cyanobacteria
HZT40_02015	COG5394	Polyhydroxyalkanoate synthesis repressor PhaR
HZT40_02020	COG1028	Short-chain dehydrogenase reductase Sdr
HZT40_02025	COG0183	Belongs to the thiolase family
HZT40_02035	COG3243	poly(R)-hydroxyalkanoic acid synthase
HZT40_02060	COG0544	peptidyl-prolyl cis-trans isomerase activity
HZT40_02065	COG0740	serine-type endopeptidase activity
HZT40_02075	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
HZT40_02080	COG0776	regulation of translation
HZT40_02105	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HZT40_02110	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HZT40_02130	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
HZT40_02145	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
HZT40_02155	COG0741	lytic transglycosylase activity
HZT40_02155	COG1388	LysM domain
HZT40_02180	COG0204	Acyl-transferase
HZT40_02180	COG0318	PFAM AMP-dependent synthetase and ligase
HZT40_02200	COG1104	cysteine desulfurase activity
HZT40_02205	COG0822	iron-sulfur transferase activity
HZT40_02210	COG0316	Belongs to the HesB IscA family
HZT40_02215	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
HZT40_02220	COG0443	Heat shock 70 kDa protein
HZT40_02230	COG2975	iron-sulfur cluster assembly
HZT40_02240	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
HZT40_02360	COG1696	Membrane protein involved in D-alanine export
HZT40_02385	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HZT40_02430	COG2801	Transposase and inactivated derivatives
HZT40_02435	COG2801	Transposase and inactivated derivatives
HZT40_02520	COG2177	Part of the ABC transporter FtsEX involved in
HZT40_02530	COG0552	protein localization to endoplasmic reticulum
HZT40_02535	COG0612	Peptidase, M16
HZT40_02550	COG0791	NLP P60 protein
HZT40_02580	COG0745	RESPONSE REGULATOR receiver
HZT40_02585	COG2205	protein histidine kinase activity
HZT40_02595	COG0583	DNA-binding transcription factor activity
HZT40_02610	COG0183	Belongs to the thiolase family
HZT40_02620	COG1024	Enoyl-CoA hydratase
HZT40_02625	COG1250	3-hydroxyacyl-CoA dehydrogenase
HZT40_02630	COG1024	Enoyl-CoA hydratase
HZT40_02650	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
HZT40_02750	COG1518	maintenance of DNA repeat elements
HZT40_02775	COG4456	Virulence-associated protein
HZT40_02785	COG1518	maintenance of DNA repeat elements
HZT40_02870	COG1253	flavin adenine dinucleotide binding
HZT40_02885	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
HZT40_02895	COG0701	Predicted permease
HZT40_02905	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HZT40_02910	COG0798	PFAM Bile acid sodium symporter
HZT40_02930	COG0058	SHG alpha-glucan phosphorylase activity
HZT40_02940	COG2270	Major facilitator Superfamily
HZT40_03075	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
HZT40_03105	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
HZT40_03125	COG0598	Magnesium transport protein CorA
HZT40_03150	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HZT40_03170	COG1028	Short-chain dehydrogenase reductase Sdr
HZT40_03240	COG1902	pentaerythritol trinitrate reductase activity
HZT40_03245	COG0583	DNA-binding transcription factor activity
HZT40_03285	COG1979	alcohol dehydrogenase
HZT40_03290	COG4566	intracellular signal transduction
HZT40_03300	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HZT40_03300	COG0543	2 iron, 2 sulfur cluster binding
HZT40_03355	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
HZT40_03360	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HZT40_03370	COG1028	Short-chain dehydrogenase reductase Sdr
HZT40_03375	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
HZT40_03400	COG3384	dioxygenase
HZT40_03405	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
HZT40_03410	COG2885	chlorophyll binding
HZT40_03450	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
HZT40_03470	COG0183	Belongs to the thiolase family
HZT40_03475	COG1250	3-hydroxyacyl-CoA dehydrogenase
HZT40_03475	COG1024	Enoyl-CoA hydratase
HZT40_03480	COG1028	Short-chain dehydrogenase reductase Sdr
HZT40_03485	COG0318	PFAM AMP-dependent synthetase and ligase
HZT40_03495	COG5499	transcription regulator containing HTH domain
HZT40_03500	COG4680	protein conserved in bacteria
HZT40_03505	COG0270	DNA (cytosine-5-)-methyltransferase activity
HZT40_03530	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
HZT40_03535	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HZT40_03550	COG1166	arginine decarboxylase activity
HZT40_03565	COG3100	YcgL domain-containing protein
HZT40_03590	COG2217	Heavy metal translocating P-type atpase
HZT40_03595	COG2217	Heavy metal translocating P-type atpase
HZT40_03605	COG0583	DNA-binding transcription factor activity
HZT40_03610	COG2920	part of a sulfur-relay system
HZT40_03620	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HZT40_03625	COG1801	Protein of unknown function DUF72
HZT40_03630	COG0227	Belongs to the bacterial ribosomal protein bL28 family
HZT40_03635	COG0267	Belongs to the bacterial ribosomal protein bL33 family
HZT40_03645	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
HZT40_03675	COG1473	amidohydrolase
HZT40_03685	COG2951	lytic endotransglycosylase activity
HZT40_03690	COG1660	Displays ATPase and GTPase activities
HZT40_03695	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HZT40_03710	COG1137	ATPase activity
HZT40_03740	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
HZT40_03750	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
HZT40_03755	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
HZT40_03765	COG0583	DNA-binding transcription factor activity
HZT40_03770	COG0489	protein tyrosine kinase activity
HZT40_03785	COG0438	transferase activity, transferring glycosyl groups
HZT40_03790	COG0367	asparagine synthase
HZT40_03795	COG0438	transferase activity, transferring glycosyl groups
HZT40_03800	COG0438	transferase activity, transferring glycosyl groups
HZT40_03810	COG0438	transferase activity, transferring glycosyl groups
HZT40_03835	COG3278	Belongs to the heme-copper respiratory oxidase family
HZT40_03850	COG2010	Cytochrome c
HZT40_03855	COG0348	domain, Protein
HZT40_03880	COG1183	phosphatidylcholine synthase activity
HZT40_03890	COG1573	uracil-dna glycosylase
HZT40_03895	COG0456	acetyltransferase
HZT40_03900	COG0617	tRNA 3'-terminal CCA addition
HZT40_03910	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HZT40_03950	COG1309	transcriptional regulator
HZT40_03985	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
HZT40_04155	COG3617	BRO family, N-terminal domain
HZT40_04220	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
HZT40_04225	COG4974	Belongs to the 'phage' integrase family
HZT40_04295	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
HZT40_04300	COG3119	arylsulfatase activity
HZT40_04325	COG0493	'glutamate synthase
HZT40_04365	COG0235	Class ii aldolase
HZT40_04370	COG3273	potassium ion transport
HZT40_04370	COG0471	metal ion transport
HZT40_04380	COG0280	phosphate acetyltransferase
HZT40_04380	COG0857	belongs to the CobB CobQ family
HZT40_04395	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
HZT40_04410	COG0179	Fumarylacetoacetate (FAA) hydrolase
HZT40_04415	COG1074	ATP-dependent DNA helicase activity
HZT40_04455	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
HZT40_04480	COG2878	Part of a membrane complex involved in electron transport
HZT40_04490	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
HZT40_04495	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
HZT40_04510	COG0424	maF-like protein
HZT40_04530	COG0312	modulator of DNA gyrase
HZT40_04535	COG0312	modulator of DNA gyrase
HZT40_04540	COG3123	guanosine phosphorylase activity
HZT40_04545	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
HZT40_04565	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HZT40_04600	COG4232	protein-disulfide reductase activity
HZT40_04635	COG0730	response to heat
HZT40_04660	COG4636	protein conserved in cyanobacteria
HZT40_04675	COG0546	phosphoglycolate phosphatase activity
HZT40_04715	COG4608	Belongs to the ABC transporter superfamily
HZT40_04720	COG4636	protein conserved in cyanobacteria
HZT40_04725	COG1414	Transcriptional regulator
HZT40_04780	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HZT40_04830	COG2824	Alkylphosphonate utilization operon protein PhnA
HZT40_04840	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
HZT40_04850	COG0825	malonyl-CoA metabolic process
HZT40_04855	COG0037	tRNA processing
HZT40_04885	COG2917	probably involved in intracellular septation
HZT40_04890	COG0009	L-threonylcarbamoyladenylate synthase
HZT40_04895	COG1994	Peptidase M50
HZT40_04900	COG0180	Tryptophanyl-tRNA synthetase
HZT40_04905	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
HZT40_04910	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
HZT40_04915	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
HZT40_04920	COG1185	polyribonucleotide nucleotidyltransferase activity
HZT40_04925	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HZT40_04930	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HZT40_04955	COG1959	2 iron, 2 sulfur cluster binding
HZT40_04960	COG0271	Belongs to the BolA IbaG family
HZT40_04965	COG0714	Associated with various cellular activities
HZT40_05015	COG1350	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
HZT40_05020	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HZT40_05030	COG0840	transmembrane signaling receptor activity
HZT40_05045	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HZT40_05055	COG0210	DNA helicase
HZT40_05080	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
HZT40_05085	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
HZT40_05090	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HZT40_05090	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HZT40_05110	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HZT40_05120	COG0567	Dehydrogenase, E1 component
HZT40_05125	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HZT40_05135	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
HZT40_05155	COG2974	May be involved in recombination
HZT40_05165	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HZT40_05165	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HZT40_05225	COG3266	domain, Protein
HZT40_05225	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
HZT40_05225	COG4932	domain protein
HZT40_05250	COG1393	Belongs to the ArsC family
HZT40_05265	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
HZT40_05280	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HZT40_05285	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
HZT40_05305	COG0439	Biotin carboxylase
HZT40_05320	COG0433	COG0433 Predicted ATPase
HZT40_05340	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
HZT40_05345	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HZT40_05350	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
HZT40_05365	COG1393	Belongs to the ArsC family
HZT40_05375	COG1648	precorrin-2 dehydrogenase activity
HZT40_05375	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
HZT40_05400	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HZT40_05405	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HZT40_05430	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
HZT40_05445	COG2205	protein histidine kinase activity
HZT40_05455	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HZT40_05510	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
HZT40_05510	COG3264	Mechanosensitive ion channel
HZT40_05520	COG0504	CTP synthase activity
HZT40_05525	COG0148	phosphopyruvate hydratase activity
HZT40_05535	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
HZT40_05540	COG0247	lactate metabolic process
HZT40_05550	COG0277	FAD linked oxidase domain protein
HZT40_05555	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
HZT40_05560	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
HZT40_05570	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
HZT40_05570	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
HZT40_05580	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HZT40_05585	COG2951	lytic endotransglycosylase activity
HZT40_05590	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
HZT40_05615	COG3118	belongs to the thioredoxin family
HZT40_05620	COG0574	Belongs to the PEP-utilizing enzyme family
HZT40_05620	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HZT40_05625	COG1404	Belongs to the peptidase S8 family
HZT40_05630	COG0322	excinuclease ABC activity
HZT40_05640	COG3743	rRNA binding
HZT40_05640	COG0261	This protein binds to 23S rRNA in the presence of protein L20
HZT40_05645	COG2885	chlorophyll binding
HZT40_05645	COG3047	cAMP biosynthetic process
HZT40_05650	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HZT40_05660	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
HZT40_05690	COG0567	Dehydrogenase, E1 component
HZT40_05695	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
HZT40_05710	COG0052	Belongs to the universal ribosomal protein uS2 family
HZT40_05715	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
HZT40_05720	COG0528	UMP kinase activity
HZT40_05725	COG0233	cytoplasmic translational termination
HZT40_05735	COG0575	Belongs to the CDS family
HZT40_05740	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
HZT40_05745	COG0750	zinc metalloprotease
HZT40_05750	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HZT40_05760	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HZT40_05765	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HZT40_05770	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HZT40_05810	COG0489	protein tyrosine kinase activity
HZT40_05825	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HZT40_05860	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
HZT40_05880	COG3118	belongs to the thioredoxin family
HZT40_05890	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
HZT40_05895	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HZT40_05930	COG2373	Large extracellular alpha-helical protein
HZT40_05935	COG4953	penicillin-binding protein 1C
HZT40_05945	COG0745	RESPONSE REGULATOR receiver
HZT40_05955	COG2850	peptidyl-arginine hydroxylation
HZT40_05990	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HZT40_06000	COG0481	GTPase activity
HZT40_06005	COG0681	Belongs to the peptidase S26 family
HZT40_06020	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
HZT40_06030	COG1381	Involved in DNA repair and RecF pathway recombination
HZT40_06035	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
HZT40_06040	COG0736	holo-[acyl-carrier-protein] synthase activity
HZT40_06065	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HZT40_06070	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HZT40_06090	COG0497	DNA recombination
HZT40_06095	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
HZT40_06100	COG1420	regulation of RNA biosynthetic process
HZT40_06120	COG1794	racemase activity, acting on amino acids and derivatives
HZT40_06125	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HZT40_06145	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HZT40_06170	COG2072	flavoprotein involved in K transport
HZT40_06225	COG0372	Belongs to the citrate synthase family
HZT40_06240	COG1210	Utp--glucose-1-phosphate uridylyltransferase
HZT40_06245	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HZT40_06280	COG0308	aminopeptidase N
HZT40_06320	COG2608	mercury ion transmembrane transporter activity
HZT40_06320	COG2217	Heavy metal translocating P-type atpase
HZT40_06330	COG1472	Belongs to the glycosyl hydrolase 3 family
HZT40_06350	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
HZT40_06355	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
HZT40_06395	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
HZT40_06410	COG0720	synthase
HZT40_06415	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
HZT40_06460	COG2204	response regulator
HZT40_06485	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
HZT40_06490	COG0492	ferredoxin-NADP+ reductase activity
HZT40_06495	COG1674	ftsk spoiiie
HZT40_06500	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
HZT40_06515	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
HZT40_06530	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
HZT40_06535	COG0183	Belongs to the thiolase family
HZT40_06545	COG0756	dUTP diphosphatase activity
HZT40_06550	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
HZT40_06555	COG2003	Belongs to the UPF0758 family
HZT40_06575	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HZT40_06585	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HZT40_06590	COG0134	indole-3-glycerol-phosphate synthase activity
HZT40_06605	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
HZT40_06610	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
HZT40_06615	COG0443	Heat shock 70 kDa protein
HZT40_06620	COG0484	heat shock protein binding
HZT40_06625	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
HZT40_06635	COG2391	methyltransferase activity
HZT40_06650	COG1850	ribulose-bisphosphate carboxylase activity
HZT40_06660	COG1858	cytochrome C peroxidase
HZT40_06670	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
HZT40_06675	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HZT40_06690	COG0287	Prephenate dehydrogenase
HZT40_06700	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
HZT40_06705	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
HZT40_06715	COG0776	regulation of translation
HZT40_06720	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
HZT40_06725	COG0284	orotidine-5'-phosphate decarboxylase activity
HZT40_06730	COG2915	High frequency lysogenization protein hflD homolog
HZT40_06760	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
HZT40_06765	COG0542	response to heat
HZT40_06770	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
HZT40_06795	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HZT40_06800	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HZT40_06810	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
HZT40_06815	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
HZT40_06835	COG0300	oxidoreductase activity
HZT40_06855	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
HZT40_06865	COG0116	Belongs to the methyltransferase superfamily
HZT40_06865	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
HZT40_06870	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
HZT40_06870	COG2755	lipolytic protein G-D-S-L family
HZT40_06880	COG0679	Auxin Efflux Carrier
HZT40_06885	COG3954	Phosphoribulokinase
HZT40_06890	COG0646	methionine synthase
HZT40_06890	COG1410	methionine synthase
HZT40_06915	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
HZT40_06925	COG0581	inorganic phosphate transmembrane transporter activity
HZT40_06930	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HZT40_06980	COG0469	pyruvate kinase activity
HZT40_06995	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
HZT40_07000	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HZT40_07005	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
HZT40_07010	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HZT40_07010	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HZT40_07015	COG2084	Dehydrogenase
HZT40_07025	COG0495	leucyl-tRNA aminoacylation
HZT40_07050	COG4555	ABC transporter
HZT40_07055	COG2183	response to ionizing radiation
HZT40_07090	COG4191	Histidine kinase
HZT40_07150	COG2719	SpoVR family
HZT40_07155	COG2718	Belongs to the UPF0229 family
HZT40_07160	COG2766	serine protein kinase
HZT40_07165	COG4452	Inner membrane protein CreD
HZT40_07175	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
HZT40_07190	COG3597	protein domain associated with
HZT40_07195	COG0326	Molecular chaperone. Has ATPase activity
HZT40_07200	COG0719	Fe-S assembly protein
HZT40_07210	COG0396	ATPase activity
HZT40_07215	COG0719	Fe-S assembly protein
HZT40_07220	COG1741	Belongs to the pirin family
HZT40_07250	COG2217	Heavy metal translocating P-type atpase
HZT40_07290	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
HZT40_07290	COG2755	lipolytic protein G-D-S-L family
HZT40_07295	COG0519	Catalyzes the synthesis of GMP from XMP
HZT40_07295	COG0518	GMP synthase (glutamine-hydrolyzing) activity
HZT40_07335	COG2205	protein histidine kinase activity
HZT40_07335	COG5002	protein histidine kinase activity
HZT40_07335	COG0784	Response regulator, receiver
HZT40_07340	COG5002	protein histidine kinase activity
HZT40_07340	COG0784	Response regulator, receiver
HZT40_07380	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HZT40_07410	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
HZT40_07420	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HZT40_07425	COG1555	photosystem II stabilization
HZT40_07600	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HZT40_07620	COG0456	acetyltransferase
HZT40_07620	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
HZT40_07770	COG0513	Belongs to the DEAD box helicase family
HZT40_07775	COG2954	triphosphatase activity
HZT40_07780	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HZT40_07795	COG1399	metal-binding, possibly nucleic acid-binding protein
HZT40_07805	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
HZT40_07815	COG0363	glucosamine-6-phosphate deaminase activity
HZT40_07820	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
HZT40_07825	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
HZT40_07860	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
HZT40_07865	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
HZT40_07890	COG1136	(ABC) transporter
HZT40_07895	COG4591	ABC-type transport system involved in lipoprotein release permease component
HZT40_07900	COG4591	ABC-type transport system involved in lipoprotein release permease component
HZT40_07915	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HZT40_07945	COG0463	Glycosyl transferase, family 2
HZT40_07955	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HZT40_07965	COG0489	protein tyrosine kinase activity
HZT40_07980	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
HZT40_07990	COG0028	Belongs to the TPP enzyme family
HZT40_08000	COG0820	rRNA (adenine-C2-)-methyltransferase activity
HZT40_08015	COG0124	histidyl-tRNA synthetase
HZT40_08020	COG2976	Protein conserved in bacteria
HZT40_08050	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
HZT40_08055	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HZT40_08070	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
HZT40_08105	COG1566	PFAM secretion protein HlyD family protein
HZT40_08115	COG2226	methyltransferase
HZT40_08120	COG1028	Short-chain dehydrogenase reductase Sdr
HZT40_08140	COG0658	competence protein
HZT40_08140	COG2333	competence protein COMEC
HZT40_08145	COG0658	competence protein
HZT40_08145	COG2333	competence protein COMEC
HZT40_08170	COG0586	Pfam SNARE associated Golgi protein
HZT40_08175	COG1960	acyl-CoA dehydrogenase activity
HZT40_08180	COG0723	plastoquinol--plastocyanin reductase activity
HZT40_08190	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HZT40_08205	COG2249	NAD(P)H dehydrogenase (quinone) activity
HZT40_08215	COG2166	iron-sulfur cluster assembly
HZT40_08225	COG0676	glucose-6-phosphate 1-epimerase activity
HZT40_08235	COG4988	ABC transporter
HZT40_08240	COG4890	Cyd operon protein YbgT
HZT40_08245	COG1294	oxidase, subunit
HZT40_08255	COG0442	prolyl-tRNA aminoacylation
HZT40_08300	COG0138	bifunctional purine biosynthesis protein purh
HZT40_08310	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
HZT40_08315	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HZT40_08330	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
HZT40_08400	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HZT40_08415	COG0436	Aminotransferase
HZT40_08455	COG2217	Heavy metal translocating P-type atpase
HZT40_08470	COG0348	domain, Protein
HZT40_08475	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
HZT40_08495	COG0754	glutathionylspermidine amidase activity
HZT40_08520	COG1132	(ABC) transporter
HZT40_08550	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
HZT40_08565	COG2801	Transposase and inactivated derivatives
HZT40_08590	COG3150	esterase
HZT40_08595	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HZT40_08610	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
HZT40_08620	COG4636	protein conserved in cyanobacteria
HZT40_08625	COG2814	Major facilitator Superfamily
HZT40_08630	COG2062	phosphohistidine phosphatase, SixA
HZT40_08635	COG0012	GTP binding
HZT40_08640	COG0193	aminoacyl-tRNA hydrolase activity
HZT40_08645	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
HZT40_08665	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
HZT40_08670	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
HZT40_08685	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
HZT40_08690	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
HZT40_08705	COG4968	Prepilin-type N-terminal cleavage methylation domain
HZT40_08715	COG4795	General secretion pathway protein
HZT40_08730	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HZT40_08740	COG0625	glutathione transferase activity
HZT40_08745	COG2857	Cytochrome c1
HZT40_08750	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
HZT40_08755	COG0723	plastoquinol--plastocyanin reductase activity
HZT40_08765	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HZT40_08835	COG1959	2 iron, 2 sulfur cluster binding
HZT40_08855	COG5487	UPF0391 membrane protein
HZT40_08865	COG3237	CsbD-like
HZT40_08890	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
HZT40_08905	COG0501	Belongs to the peptidase M48B family
HZT40_08910	COG1704	LemA family
HZT40_08920	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HZT40_08925	COG1704	LemA family
HZT40_09010	COG0633	Ferredoxin
HZT40_09015	COG0426	domain, Protein
HZT40_09100	COG0129	dihydroxy-acid dehydratase activity
HZT40_09295	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
HZT40_09310	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
HZT40_09320	COG0688	phosphatidylethanolamine metabolic process
HZT40_09340	COG3220	belongs to the UPF0276 family
HZT40_09350	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HZT40_09375	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
HZT40_09380	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
HZT40_09385	COG0291	Belongs to the bacterial ribosomal protein bL35 family
HZT40_09395	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
HZT40_09410	COG4636	protein conserved in cyanobacteria
HZT40_09465	COG2244	polysaccharide biosynthetic process
HZT40_09500	COG4464	protein tyrosine phosphatase activity
HZT40_09510	COG0489	protein tyrosine kinase activity
HZT40_09545	COG2814	Major facilitator Superfamily
HZT40_09555	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
HZT40_09575	COG0501	Belongs to the peptidase M48B family
HZT40_09600	COG1266	CAAX protease self-immunity
HZT40_09605	COG0640	Transcriptional regulator
HZT40_09610	COG0601	transmembrane transport
HZT40_09615	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HZT40_09620	COG0444	Belongs to the ABC transporter superfamily
HZT40_09625	COG0444	Belongs to the ABC transporter superfamily
HZT40_09635	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
HZT40_09635	COG4797	methyltransferase
HZT40_09645	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
HZT40_09680	COG2226	methyltransferase
HZT40_09680	COG1073	alpha beta
HZT40_09690	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
HZT40_09705	COG0525	valine-tRNA ligase activity
HZT40_09760	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HZT40_09790	COG1132	(ABC) transporter
HZT40_09800	COG0842	Transport permease protein
HZT40_09805	COG1131	(ABC) transporter
HZT40_09810	COG0583	DNA-binding transcription factor activity
HZT40_09830	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
HZT40_09840	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
HZT40_09850	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
HZT40_09855	COG1546	Belongs to the CinA family
HZT40_09860	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
HZT40_09860	COG0616	signal peptide processing
HZT40_09885	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HZT40_09890	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HZT40_09925	COG0330	HflC and HflK could
HZT40_09930	COG0330	HflC and HflK could
HZT40_09940	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
HZT40_09945	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
HZT40_09950	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
HZT40_09965	COG1538	Outer membrane efflux protein
HZT40_09980	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HZT40_09990	COG0489	protein tyrosine kinase activity
HZT40_10050	COG2914	Belongs to the UPF0125 (RnfH) family
HZT40_10055	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
HZT40_10060	COG3411	Ferredoxin
HZT40_10100	COG3245	cytochrome
HZT40_10115	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HZT40_10115	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
HZT40_10125	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
HZT40_10140	COG2197	response regulator
HZT40_10145	COG3850	Histidine kinase
HZT40_10155	COG1797	cobyrinic acid a,c-diamide synthase activity
HZT40_10160	COG0429	hydrolase of the alpha beta-hydrolase fold
HZT40_10190	COG3597	protein domain associated with
HZT40_10195	COG3597	protein domain associated with
HZT40_10200	COG0745	RESPONSE REGULATOR receiver
HZT40_10215	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HZT40_10220	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
HZT40_10255	COG1845	cytochrome c oxidase, subunit III
HZT40_10260	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
HZT40_10265	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HZT40_10270	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
HZT40_10280	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HZT40_10285	COG1612	heme a metabolic process
HZT40_10305	COG0436	Aminotransferase
HZT40_10335	COG2321	neutral zinc metallopeptidase
HZT40_10355	COG3853	Toxic anion resistance protein (TelA)
HZT40_10380	COG0791	NLP P60 protein
HZT40_10385	COG1388	LysM domain
HZT40_10415	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
HZT40_10425	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HZT40_10460	COG2205	protein histidine kinase activity
HZT40_10460	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HZT40_10465	COG0438	transferase activity, transferring glycosyl groups
HZT40_10535	COG0737	Belongs to the 5'-nucleotidase family
HZT40_10565	COG1764	response to oxidative stress
HZT40_10570	COG4977	sequence-specific DNA binding
HZT40_10570	COG1917	Cupin 2, conserved barrel domain protein
HZT40_10580	COG2226	methyltransferase
HZT40_10610	COG4569	acetaldehyde dehydrogenase (acetylating) activity
HZT40_10615	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HZT40_10625	COG1942	4-Oxalocrotonate Tautomerase
HZT40_10635	COG0534	Mate efflux family protein
HZT40_10675	COG0739	heme binding
HZT40_10675	COG0741	lytic transglycosylase activity
HZT40_10675	COG1196	nuclear chromosome segregation
HZT40_10685	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HZT40_10740	COG0582	viral genome integration into host DNA
HZT40_10750	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HZT40_10840	COG2176	DNA-directed DNA polymerase activity
HZT40_10845	COG0419	ATPase involved in DNA repair
HZT40_10850	COG0420	3'-5' exonuclease activity
HZT40_10910	COG0714	Associated with various cellular activities
HZT40_10920	COG1845	cytochrome c oxidase, subunit III
HZT40_10935	COG3850	Histidine kinase
HZT40_10950	COG2223	nitrite transmembrane transporter activity
HZT40_10955	COG2920	part of a sulfur-relay system
HZT40_10960	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
HZT40_10970	COG2181	nitrate reductase activity
HZT40_10980	COG0303	'Molybdopterin
HZT40_10995	COG0826	peptidase U32
HZT40_11020	COG0505	Belongs to the CarA family
HZT40_11035	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HZT40_11040	COG1242	4 iron, 4 sulfur cluster binding
HZT40_11065	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
HZT40_11080	COG0577	efflux transmembrane transporter activity
HZT40_11080	COG1136	(ABC) transporter
HZT40_11100	COG1309	transcriptional regulator
HZT40_11110	COG4771	TonB-dependent receptor
HZT40_11130	COG2010	Cytochrome c
HZT40_11230	COG3311	Transcriptional regulator
HZT40_11235	COG1569	PIN domain
HZT40_11275	COG2003	Belongs to the UPF0758 family
HZT40_11330	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HZT40_11375	COG2894	cell division
HZT40_11400	COG0358	DNA primase activity
HZT40_11405	COG0070	glutamate synthase
HZT40_11405	COG0069	glutamate synthase activity
HZT40_11405	COG0067	glutamate synthase
HZT40_11425	COG0438	transferase activity, transferring glycosyl groups
HZT40_11435	COG1215	transferase activity, transferring glycosyl groups
HZT40_11440	COG0438	transferase activity, transferring glycosyl groups
HZT40_11450	COG0438	transferase activity, transferring glycosyl groups
HZT40_11485	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
HZT40_11505	COG1525	nuclease
HZT40_11520	COG1509	lysine 2,3-aminomutase activity
HZT40_11525	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
HZT40_11530	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
HZT40_11545	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HZT40_11550	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
HZT40_11555	COG0303	'Molybdopterin
HZT40_11595	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
HZT40_11600	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
HZT40_11600	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
HZT40_11605	COG2814	Major facilitator Superfamily
HZT40_11610	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
HZT40_11620	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HZT40_11635	COG5002	protein histidine kinase activity
HZT40_11635	COG5001	Diguanylate cyclase
HZT40_11640	COG0335	large ribosomal subunit rRNA binding
HZT40_11645	COG0336	Belongs to the RNA methyltransferase TrmD family
HZT40_11655	COG0228	four-way junction DNA binding
HZT40_11660	COG3738	Protein conserved in bacteria
HZT40_11680	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
HZT40_11690	COG4536	flavin adenine dinucleotide binding
HZT40_11700	COG0513	Belongs to the DEAD box helicase family
HZT40_11710	COG0494	nUDIX hydrolase
HZT40_11715	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
HZT40_11720	COG0653	protein targeting
HZT40_11735	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
HZT40_11755	COG1181	Belongs to the D-alanine--D-alanine ligase family
HZT40_11760	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HZT40_11765	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
HZT40_11775	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
HZT40_11780	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HZT40_11790	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HZT40_11805	COG0275	rRNA processing
HZT40_11820	COG0515	serine threonine protein kinase
HZT40_11820	COG1262	PFAM Formylglycine-generating sulfatase enzyme
HZT40_11845	COG1262	PFAM Formylglycine-generating sulfatase enzyme
HZT40_11885	COG0582	viral genome integration into host DNA
HZT40_11900	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HZT40_11915	COG1322	Protein conserved in bacteria
HZT40_11930	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
HZT40_11940	COG0850	regulation of cytokinetic process
HZT40_11955	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
HZT40_11980	COG3344	reverse transcriptase
HZT40_12110	COG3220	belongs to the UPF0276 family
HZT40_12125	COG1295	ribonuclease BN
HZT40_12145	COG2204	response regulator
HZT40_12150	COG4191	Histidine kinase
HZT40_12160	COG0659	secondary active sulfate transmembrane transporter activity
HZT40_12165	COG0288	reversible hydration of carbon dioxide
HZT40_12170	COG3118	belongs to the thioredoxin family
HZT40_12175	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
HZT40_12230	COG0668	transmembrane transport
HZT40_12245	COG0745	RESPONSE REGULATOR receiver
HZT40_12250	COG2205	protein histidine kinase activity
HZT40_12260	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HZT40_12265	COG0305	Participates in initiation and elongation during chromosome replication
HZT40_12275	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
HZT40_12280	COG0360	Binds together with S18 to 16S ribosomal RNA
HZT40_12285	COG2815	serine threonine protein kinase
HZT40_12285	COG0515	serine threonine protein kinase
HZT40_12320	COG0741	lytic transglycosylase activity
HZT40_12330	COG2379	hydroxypyruvate reductase
HZT40_12380	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
HZT40_12395	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
HZT40_12400	COG1366	Belongs to the anti-sigma-factor antagonist family
HZT40_12405	COG2208	phosphoserine phosphatase activity
HZT40_12430	COG0232	Belongs to the dGTPase family. Type 2 subfamily
HZT40_12435	COG1295	ribonuclease BN
HZT40_12495	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
HZT40_12505	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
HZT40_12535	COG2304	oxidoreductase activity
HZT40_12540	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HZT40_12580	COG0583	DNA-binding transcription factor activity
HZT40_12585	COG3279	Response regulator of the LytR AlgR family
HZT40_12585	COG5000	phosphorelay sensor kinase activity
HZT40_12610	COG0542	response to heat
HZT40_12620	COG3608	succinylglutamate desuccinylase aspartoacylase
HZT40_12620	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
HZT40_12630	COG0402	S-adenosylhomocysteine deaminase activity
HZT40_12655	COG1529	Aldehyde oxidase and xanthine dehydrogenase
HZT40_12695	COG4266	Belongs to the allantoicase family
HZT40_12700	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
HZT40_12705	COG2233	PERMEase
HZT40_12730	COG0804	urea catabolic process
HZT40_12740	COG3645	SOS response
HZT40_12750	COG3177	Filamentation induced by cAMP protein fic
HZT40_12775	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
HZT40_12785	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
HZT40_12790	COG0830	nickel cation binding
HZT40_12815	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
HZT40_12825	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HZT40_12840	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
HZT40_12860	COG0837	glucose binding
HZT40_12875	COG1446	asparaginase
HZT40_12955	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
HZT40_12975	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
HZT40_12985	COG1487	ribonuclease activity
HZT40_13010	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HZT40_13020	COG2204	response regulator
HZT40_13025	COG5002	protein histidine kinase activity
HZT40_13055	COG0243	molybdopterin cofactor binding
HZT40_13060	COG0437	4 iron, 4 sulfur cluster binding
HZT40_13105	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
HZT40_13130	COG1070	Carbohydrate kinase
HZT40_13145	COG0215	cysteine-tRNA ligase activity
HZT40_13150	COG0446	pyridine nucleotide-disulphide oxidoreductase
HZT40_13155	COG0459	protein refolding
HZT40_13165	COG5002	protein histidine kinase activity
HZT40_13165	COG5001	Diguanylate cyclase
HZT40_13200	COG0628	permease
HZT40_13210	COG2885	chlorophyll binding
HZT40_13215	COG0564	pseudouridine synthase activity
HZT40_13225	COG0589	response to stress
HZT40_13235	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
HZT40_13260	COG0535	radical SAM domain protein
HZT40_13310	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HZT40_13335	COG2852	Protein conserved in bacteria
HZT40_13340	COG0514	ATP-dependent DNA helicase (RecQ)
HZT40_13350	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HZT40_13365	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
HZT40_13375	COG0463	Glycosyl transferase, family 2
HZT40_13390	COG0795	lipopolysaccharide-transporting ATPase activity
HZT40_13410	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
HZT40_13415	COG0316	Belongs to the HesB IscA family
HZT40_13430	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
HZT40_13450	COG2192	nodulation
HZT40_13460	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
HZT40_13500	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HZT40_13590	COG0488	(ABC) transporter
HZT40_13600	COG0583	DNA-binding transcription factor activity
HZT40_13605	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HZT40_13620	COG2165	general secretion pathway protein
HZT40_13635	COG1459	type II secretion system
HZT40_13640	COG1459	type II secretion system
HZT40_13645	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HZT40_13685	COG0778	Nitroreductase
HZT40_13710	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HZT40_13720	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
HZT40_13725	COG1902	pentaerythritol trinitrate reductase activity
HZT40_13735	COG0438	transferase activity, transferring glycosyl groups
HZT40_13740	COG0561	phosphatase activity
HZT40_13740	COG3100	YcgL domain-containing protein
HZT40_13755	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HZT40_13790	COG0709	Synthesizes selenophosphate from selenide and ATP
HZT40_13795	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
HZT40_13800	COG0033	Phosphoglucomutase
HZT40_13810	COG1959	2 iron, 2 sulfur cluster binding
HZT40_13815	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
HZT40_13820	COG2363	Small membrane protein
HZT40_13825	COG0742	ribosomal rna small subunit methyltransferase
HZT40_13830	COG2900	Belongs to the SlyX family
HZT40_13835	COG0137	argininosuccinate synthase activity
HZT40_13845	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
HZT40_13865	COG0642	Histidine kinase
HZT40_13870	COG0745	RESPONSE REGULATOR receiver
HZT40_13875	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
HZT40_13885	COG0579	oxidoreductase
HZT40_13900	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
HZT40_13905	COG2835	tetraacyldisaccharide 4'-kinase activity
HZT40_13910	COG1663	tetraacyldisaccharide 4'-kinase activity
HZT40_13915	COG1132	(ABC) transporter
HZT40_13935	COG0741	lytic transglycosylase activity
HZT40_13945	COG2171	N-acyltransferase activity
HZT40_13950	COG0436	Aminotransferase
HZT40_13955	COG0573	inorganic phosphate transmembrane transporter activity
HZT40_13990	COG0306	phosphate transporter
HZT40_13995	COG1392	Phosphate transport regulator
HZT40_14000	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HZT40_14030	COG2308	Evidence 4 Homologs of previously reported genes of
HZT40_14040	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
HZT40_14085	COG0569	domain protein
HZT40_14090	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HZT40_14095	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HZT40_14110	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HZT40_14130	COG4597	amino acid ABC transporter
HZT40_14135	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HZT40_14140	COG0815	Transfers the fatty acyl group on membrane lipoproteins
HZT40_14145	COG4535	Mg2 and Co2 transporter CorC
HZT40_14150	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
HZT40_14155	COG1702	phosphate starvation-inducible protein PhoH
HZT40_14165	COG0784	Response regulator, receiver
HZT40_14165	COG2205	protein histidine kinase activity
HZT40_14165	COG5002	protein histidine kinase activity
HZT40_14170	COG0812	UDP-N-acetylmuramate dehydrogenase activity
HZT40_14175	COG2010	Cytochrome c
HZT40_14195	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
HZT40_14215	COG0028	Belongs to the TPP enzyme family
HZT40_14220	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
HZT40_14225	COG0175	sulfate reduction
HZT40_14230	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HZT40_14250	COG2895	sulfate adenylyltransferase (ATP) activity
HZT40_14255	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
HZT40_14285	COG0583	DNA-binding transcription factor activity
HZT40_14315	COG0509	glycine decarboxylation via glycine cleavage system
HZT40_14320	COG0404	The glycine cleavage system catalyzes the degradation of glycine
HZT40_14325	COG1863	multisubunit Na H antiporter MnhE subunit
HZT40_14345	COG2111	Na H antiporter
HZT40_14350	COG1006	Multisubunit Na H antiporter MnhC subunit
HZT40_14355	COG0651	ATP synthesis coupled electron transport
HZT40_14365	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HZT40_14370	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HZT40_14370	COG0649	NAD binding
HZT40_14430	COG3008	intermembrane lipid transfer
HZT40_14435	COG2995	paraquat-inducible protein a
HZT40_14440	COG2995	paraquat-inducible protein a
HZT40_14445	COG0471	metal ion transport
HZT40_14445	COG3273	potassium ion transport
HZT40_14450	COG3153	acetyltransferase
HZT40_14450	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HZT40_14480	COG1858	cytochrome C peroxidase
HZT40_14485	COG2193	ferroxidase activity
HZT40_14520	COG0642	Histidine kinase
HZT40_14525	COG0745	RESPONSE REGULATOR receiver
HZT40_14615	COG1715	Restriction endonuclease
HZT40_14635	COG2207	Transcriptional regulator
HZT40_14635	COG3708	Transcriptional regulator
HZT40_14675	COG0735	belongs to the Fur family
HZT40_14695	COG0577	efflux transmembrane transporter activity
HZT40_14720	COG0811	peptide transport
HZT40_14735	COG4774	siderophore transport
HZT40_14740	COG3128	pkhd-type hydroxylase
HZT40_14745	COG1840	ABC-type Fe3 transport system, periplasmic component
HZT40_14750	COG2119	membrane
HZT40_14795	COG0450	alkyl hydroperoxide reductase
HZT40_14825	COG1858	cytochrome C peroxidase
HZT40_14870	COG1178	ABC-type Fe3 transport system permease component
HZT40_14875	COG3842	ATPase activity
HZT40_14880	COG2402	Toxic component of a toxin-antitoxin (TA) module. An RNase
HZT40_14895	COG1136	(ABC) transporter
HZT40_14895	COG0577	efflux transmembrane transporter activity
HZT40_14925	COG4191	Histidine kinase
HZT40_14945	COG5002	protein histidine kinase activity
HZT40_14945	COG0784	Response regulator, receiver
HZT40_14955	COG4191	Histidine kinase
HZT40_14970	COG0745	RESPONSE REGULATOR receiver
HZT40_15000	COG0318	PFAM AMP-dependent synthetase and ligase
HZT40_15005	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
HZT40_15035	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
HZT40_15055	COG3668	Plasmid stabilization system
HZT40_15065	COG0745	RESPONSE REGULATOR receiver
HZT40_15070	COG0642	Histidine kinase
HZT40_15105	COG0297	glycogen (starch) synthase activity
HZT40_15175	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
HZT40_15220	COG0356	it plays a direct role in the translocation of protons across the membrane
HZT40_15230	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
HZT40_15230	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HZT40_15235	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
HZT40_15240	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
HZT40_15245	COG1404	Belongs to the peptidase S8 family
HZT40_15250	COG0242	peptide deformylase activity
HZT40_15285	COG0842	Transport permease protein
HZT40_15310	COG0564	pseudouridine synthase activity
HZT40_15320	COG1940	carbohydrate kinase activity
HZT40_15325	COG2204	response regulator
HZT40_15330	COG0791	NLP P60 protein
HZT40_15350	COG1011	Hydrolase
HZT40_15365	COG0494	nUDIX hydrolase
HZT40_15370	COG1218	3'(2'),5'-bisphosphate nucleotidase
HZT40_15385	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HZT40_15415	COG0355	proton-transporting ATP synthase activity, rotational mechanism
HZT40_15420	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
HZT40_15425	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
HZT40_15430	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
HZT40_15435	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HZT40_15440	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
HZT40_15445	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HZT40_15450	COG0356	it plays a direct role in the translocation of protons across the membrane
HZT40_15470	COG3275	phosphorelay sensor kinase activity
HZT40_15475	COG0165	Argininosuccinate lyase
HZT40_15480	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
HZT40_15485	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
HZT40_15495	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
HZT40_15500	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
HZT40_15505	COG1923	regulation of RNA biosynthetic process
HZT40_15510	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
HZT40_15535	COG0745	RESPONSE REGULATOR receiver
HZT40_15550	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
HZT40_15555	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
HZT40_15640	COG2268	Band 7 protein
HZT40_15675	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
HZT40_15705	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
HZT40_15715	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
HZT40_15720	COG0425	Belongs to the sulfur carrier protein TusA family
HZT40_15725	COG0156	8-amino-7-oxononanoate synthase activity
HZT40_15730	COG0585	pseudouridine synthase activity
HZT40_15740	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
HZT40_15750	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
HZT40_15805	COG0151	Belongs to the GarS family
HZT40_15815	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
HZT40_15840	COG0517	IMP dehydrogenase activity
HZT40_15840	COG0617	tRNA 3'-terminal CCA addition
HZT40_15840	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
HZT40_15860	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
HZT40_15870	COG1805	sodium ion transport
HZT40_15895	COG2211	Major facilitator Superfamily
HZT40_15900	COG3876	Protein conserved in bacteria
HZT40_15910	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
HZT40_15915	COG0519	Catalyzes the synthesis of GMP from XMP
HZT40_15930	COG1187	pseudouridine synthase activity
HZT40_15975	COG0037	tRNA processing
HZT40_15980	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HZT40_15995	COG3178	'Phosphotransferase
HZT40_16000	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
HZT40_16005	COG3264	Mechanosensitive ion channel
HZT40_16005	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
HZT40_16010	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
HZT40_16015	COG1469	GTP cyclohydrolase I activity
HZT40_16030	COG1077	Cell shape determining protein MreB Mrl
HZT40_16035	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
HZT40_16045	COG0596	Alpha beta hydrolase
HZT40_16065	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HZT40_16070	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HZT40_16075	COG0154	amidase activity
HZT40_16110	COG5265	(ABC) transporter
HZT40_16115	COG1187	pseudouridine synthase activity
HZT40_16125	COG0194	GDP metabolic process
HZT40_16130	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HZT40_16135	COG3028	Belongs to the UPF0307 family
HZT40_16145	COG2146	nitrite reductase [NAD(P)H] activity
HZT40_16150	COG3738	Protein conserved in bacteria
HZT40_16180	COG1944	ATP diphosphatase activity
HZT40_16195	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
HZT40_16200	COG0598	Magnesium transport protein CorA
HZT40_16215	COG0494	nUDIX hydrolase
HZT40_16220	COG0583	DNA-binding transcription factor activity
HZT40_16225	COG0432	Pfam Uncharacterised protein family UPF0047
HZT40_16235	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
HZT40_16295	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
HZT40_16305	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
HZT40_16310	COG2251	uridine kinase activity
HZT40_16310	COG0195	Participates in both transcription termination and antitermination
HZT40_16315	COG0779	Required for maturation of 30S ribosomal subunits
HZT40_16330	COG1007	ATP synthesis coupled electron transport
HZT40_16345	COG0713	ATP synthesis coupled electron transport
HZT40_16355	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HZT40_16365	COG1034	ATP synthesis coupled electron transport
HZT40_16380	COG0649	NAD binding
HZT40_16385	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HZT40_16410	COG0149	triose-phosphate isomerase activity
HZT40_16420	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
HZT40_16465	COG0493	'glutamate synthase
HZT40_16480	COG2920	part of a sulfur-relay system
HZT40_16485	COG2168	tRNA wobble position uridine thiolation
HZT40_16490	COG2923	Belongs to the DsrF TusC family
HZT40_16495	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
HZT40_16500	COG2221	Nitrite and sulphite reductase 4Fe-4S
HZT40_16505	COG2221	Nitrite and sulphite reductase 4Fe-4S
HZT40_16565	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HZT40_16580	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HZT40_16585	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HZT40_16590	COG0463	Glycosyl transferase, family 2
HZT40_16625	COG3128	pkhd-type hydroxylase
HZT40_16635	COG3258	Cytochrome c
HZT40_16650	COG1643	Atp-dependent helicase
HZT40_16660	COG2814	Major facilitator Superfamily
HZT40_16665	COG0583	DNA-binding transcription factor activity
HZT40_16685	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HZT40_16700	COG0101	tRNA pseudouridine synthase activity
HZT40_16710	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HZT40_16730	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
HZT40_16840	COG0537	adenosine 5'-monophosphoramidase activity
HZT40_16860	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
HZT40_16880	COG0745	RESPONSE REGULATOR receiver
HZT40_16895	COG0643	Histidine kinase
HZT40_16895	COG0784	Response regulator, receiver
HZT40_16895	COG2198	Histidine kinase
HZT40_16900	COG0745	RESPONSE REGULATOR receiver
HZT40_16925	COG1234	tRNA 3'-trailer cleavage
HZT40_16930	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
HZT40_16935	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HZT40_16940	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
HZT40_16945	COG0586	Pfam SNARE associated Golgi protein
HZT40_17040	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HZT40_17045	COG0515	serine threonine protein kinase
HZT40_17045	COG3266	domain, Protein
HZT40_17060	COG0583	DNA-binding transcription factor activity
HZT40_17070	COG3038	cytochrome b561
HZT40_17090	COG0708	Exodeoxyribonuclease III
HZT40_17095	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
HZT40_17100	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HZT40_17105	COG1477	protein flavinylation
HZT40_17140	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HZT40_17155	COG2165	general secretion pathway protein
HZT40_17175	COG1040	competence protein
HZT40_17180	COG1561	YicC-like family, N-terminal region
HZT40_17195	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HZT40_17200	COG0218	Necessary for normal cell division and for the maintenance of normal septation
HZT40_17210	COG1333	cytochrome c biogenesis protein
HZT40_17225	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
HZT40_17230	COG0321	lipoyl(octanoyl) transferase activity
HZT40_17235	COG2921	Belongs to the UPF0250 family
HZT40_17240	COG1686	Belongs to the peptidase S11 family
HZT40_17245	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
HZT40_17250	COG2951	lytic endotransglycosylase activity
HZT40_17255	COG0772	Belongs to the SEDS family
HZT40_17265	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
HZT40_17275	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
HZT40_17280	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
HZT40_17290	COG0792	nuclease activity
HZT40_17295	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
HZT40_17300	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
HZT40_17300	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
HZT40_17310	COG2211	Major facilitator Superfamily
HZT40_17350	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HZT40_17365	COG0596	Alpha beta hydrolase
HZT40_17370	COG2326	polyphosphate kinase activity
HZT40_17390	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
HZT40_17395	COG2983	Belongs to the UPF0260 family
HZT40_17415	COG2046	Belongs to the sulfate adenylyltransferase family
HZT40_17420	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
HZT40_17430	COG0811	peptide transport
HZT40_17440	COG0864	Transcriptional regulator
HZT40_17450	COG1858	cytochrome C peroxidase
HZT40_17470	COG4191	Histidine kinase
HZT40_17475	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
HZT40_17500	COG0625	glutathione transferase activity
HZT40_17525	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HZT40_17530	COG1758	RNA polymerase activity
HZT40_17535	COG2176	DNA-directed DNA polymerase activity
HZT40_17540	COG0517	IMP dehydrogenase activity
HZT40_17565	COG0741	lytic transglycosylase activity
HZT40_17570	COG2967	ApaG domain
HZT40_17575	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
HZT40_17595	COG0142	geranyltranstransferase activity
HZT40_17605	COG0784	Response regulator, receiver
HZT40_17605	COG2205	protein histidine kinase activity
HZT40_17605	COG2198	Histidine kinase
HZT40_17625	COG1592	Rubrerythrin
HZT40_17640	COG0791	NLP P60 protein
HZT40_17645	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
HZT40_17650	COG1765	OsmC-like protein
HZT40_17655	COG2841	Protein conserved in bacteria
HZT40_17665	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
HZT40_17670	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
HZT40_17695	COG0793	Belongs to the peptidase S41A family
HZT40_17705	COG0315	cyclic pyranopterin monophosphate synthase activity
HZT40_17710	COG0314	molybdopterin synthase activity
HZT40_17715	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
HZT40_17725	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HZT40_17730	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
HZT40_17770	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HZT40_17795	COG1090	epimerase
HZT40_17810	COG2354	Protein conserved in bacteria
HZT40_17825	COG0714	Associated with various cellular activities
HZT40_17830	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
HZT40_17840	COG1162	GTPase activity
HZT40_17850	COG0741	lytic transglycosylase activity
HZT40_17865	COG3297	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
HZT40_17885	COG0004	ammonium transporteR
HZT40_17905	COG1032	radical SAM domain protein
HZT40_17985	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
HZT40_17990	COG1859	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase
HZT40_18030	COG1196	nuclear chromosome segregation
HZT40_18030	COG0741	lytic transglycosylase activity
HZT40_18030	COG0739	heme binding
HZT40_18060	COG4249	Peptidase C14 caspase catalytic subunit p20
HZT40_18060	COG2319	Wd-40 repeat
HZT40_18100	COG0330	HflC and HflK could
HZT40_18110	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
HZT40_18120	COG5001	Diguanylate cyclase
HZT40_18120	COG1716	ATPase activity
HZT40_18150	COG0674	pyruvate-flavodoxin oxidoreductase activity
HZT40_18165	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HZT40_18170	COG0508	dehydrogenase complex catalyzes the overall conversion of
HZT40_18175	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
HZT40_18195	COG1139	Iron-sulfur cluster binding protein
HZT40_18225	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
HZT40_18240	COG0582	viral genome integration into host DNA
HZT40_18290	COG1674	ftsk spoiiie
HZT40_18315	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
HZT40_18360	COG0500	methyltransferase
HZT40_18365	COG0189	ligase activity
HZT40_18430	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HZT40_18505	COG3541	Predicted nucleotidyltransferase
HZT40_18525	COG4456	Virulence-associated protein
HZT40_18540	COG1859	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase
HZT40_18550	COG1051	belongs to the nudix hydrolase family
HZT40_18550	COG1056	cytidyltransferase-related domain
HZT40_18580	COG4717	serine-type aminopeptidase activity
HZT40_18585	COG0420	3'-5' exonuclease activity
HZT40_18595	COG0697	spore germination
HZT40_18600	COG2207	Transcriptional regulator
HZT40_18620	COG0745	RESPONSE REGULATOR receiver
HZT40_18625	COG2205	protein histidine kinase activity
HZT40_18630	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HZT40_18670	COG0418	dihydroorotase activity
HZT40_18695	COG0196	riboflavin kinase activity
HZT40_18700	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HZT40_18705	COG0859	PFAM glycosyl transferase family 9
HZT40_18730	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HZT40_18735	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
HZT40_18750	COG0706	membrane insertase activity
HZT40_18755	COG0594	ribonuclease P activity
HZT40_18760	COG0230	Belongs to the bacterial ribosomal protein bL34 family
HZT40_18775	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
HZT40_18780	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
HZT40_18785	COG0187	DNA topoisomerase II activity
HZT40_18795	COG0708	Exodeoxyribonuclease III
HZT40_18810	COG1752	Esterase of the alpha-beta hydrolase superfamily
HZT40_18830	COG0181	hydroxymethylbilane synthase activity
HZT40_18855	COG0281	malic enzyme
HZT40_18860	COG4783	chaperone-mediated protein folding
HZT40_18875	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HZT40_18880	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
HZT40_18920	COG0840	transmembrane signaling receptor activity
HZT40_18950	COG0084	hydrolase, TatD family'
HZT40_18955	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
HZT40_18960	COG4206	TonB-dependent receptor
HZT40_18975	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HZT40_19000	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
HZT40_19005	COG0406	alpha-ribazole phosphatase activity
HZT40_19010	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
HZT40_19020	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
HZT40_19030	COG1678	Uncharacterized ACR, COG1678
HZT40_19050	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HZT40_19065	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
HZT40_19070	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
HZT40_19075	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
HZT40_19085	COG2813	Specifically methylates the guanine in position
HZT40_19090	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HZT40_19100	COG1404	Belongs to the peptidase S8 family
HZT40_19105	COG0408	coproporphyrinogen oxidase activity
HZT40_19120	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HZT40_19125	COG0488	(ABC) transporter
HZT40_19135	COG2878	Part of a membrane complex involved in electron transport
HZT40_19135	COG1148	4fe-4S ferredoxin, iron-sulfur binding domain protein
HZT40_19140	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
HZT40_19140	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
HZT40_19140	COG1013	pyruvate-flavodoxin oxidoreductase activity
HZT40_19140	COG0674	pyruvate-flavodoxin oxidoreductase activity
HZT40_19145	COG4656	Part of a membrane complex involved in electron transport
HZT40_19150	COG4658	electron transport chain
HZT40_19160	COG4660	Part of a membrane complex involved in electron transport
HZT40_19165	COG4657	Part of a membrane complex involved in electron transport
HZT40_19200	COG0301	tRNA thio-modification
HZT40_19205	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HZT40_19210	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
HZT40_19215	COG0131	Imidazoleglycerol-phosphate dehydratase
HZT40_19220	COG0730	response to heat
HZT40_19225	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
HZT40_19265	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HZT40_19280	COG1690	Belongs to the RtcB family
HZT40_19295	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
HZT40_19320	COG1864	DNA RNA non-specific endonuclease
HZT40_19320	COG3591	Belongs to the peptidase S1B family
HZT40_19340	COG0437	4 iron, 4 sulfur cluster binding
HZT40_19345	COG3302	dmso reductase anchor subunit
HZT40_19350	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HZT40_19355	COG2873	o-acetylhomoserine
HZT40_19375	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
HZT40_19385	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
HZT40_19395	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
HZT40_19400	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
HZT40_19405	COG1803	Methylglyoxal synthase
HZT40_19420	COG1234	tRNA 3'-trailer cleavage
HZT40_19425	COG0745	RESPONSE REGULATOR receiver
HZT40_19430	COG2205	protein histidine kinase activity
HZT40_19435	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HZT40_19455	COG1346	cytolysis
HZT40_19490	COG3245	cytochrome
HZT40_19600	COG1132	(ABC) transporter
HZT40_19625	COG4104	PAAR repeat-containing protein
HZT40_19625	COG3209	COG3209 Rhs family protein
HZT40_19660	COG3209	COG3209 Rhs family protein
HZT40_19700	COG4104	PAAR repeat-containing protein
HZT40_19700	COG3209	COG3209 Rhs family protein
HZT40_19735	COG2801	Transposase and inactivated derivatives
HZT40_19770	COG1104	cysteine desulfurase activity
HZT40_19795	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
HZT40_19800	COG2922	Belongs to the Smg family
HZT40_19805	COG0758	DNA mediated transformation
HZT40_19830	COG5000	phosphorelay sensor kinase activity
HZT40_19835	COG2204	response regulator
HZT40_19840	COG0569	domain protein
HZT40_19845	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HZT40_19850	COG3001	Fructosamine kinase
HZT40_19860	COG0166	Belongs to the GPI family
HZT40_19865	COG0837	glucose binding
HZT40_19885	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
HZT40_19890	COG0297	glycogen (starch) synthase activity
HZT40_19895	COG0058	SHG alpha-glucan phosphorylase activity
HZT40_19900	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
HZT40_19910	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HZT40_19925	COG3647	Membrane
HZT40_19975	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HZT40_20015	COG0129	dihydroxy-acid dehydratase activity
HZT40_20025	COG2204	response regulator
HZT40_20045	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
HZT40_20050	COG2027	D-alanyl-D-alanine carboxypeptidase
HZT40_20055	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HZT40_20070	COG0543	2 iron, 2 sulfur cluster binding
HZT40_20070	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HZT40_20075	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
HZT40_20095	COG0210	DNA helicase
HZT40_20120	COG0259	pyridoxamine-phosphate oxidase activity
HZT40_20130	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
HZT40_20140	COG0107	imidazoleglycerol-phosphate synthase activity
HZT40_20165	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HZT40_20180	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
HZT40_20200	COG2022	thiamine diphosphate biosynthetic process
HZT40_20205	COG0220	tRNA (guanine-N7-)-methyltransferase activity
HZT40_20220	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
HZT40_20250	COG1773	rubredoxin
HZT40_20270	COG0179	Fumarylacetoacetate (FAA) hydrolase
HZT40_20275	COG0606	chelatase, subunit chli
HZT40_20335	COG2815	serine threonine protein kinase
HZT40_20335	COG0515	serine threonine protein kinase
HZT40_20350	COG0631	protein serine/threonine phosphatase activity
HZT40_20475	COG0529	Catalyzes the synthesis of activated sulfate
HZT40_20475	COG2046	Belongs to the sulfate adenylyltransferase family
HZT40_20490	COG0641	radical SAM
HZT40_20535	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HZT40_20535	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
HZT40_20545	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HZT40_20550	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HZT40_20550	COG3320	Male sterility
HZT40_20555	COG0010	Belongs to the arginase family
HZT40_20575	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HZT40_20580	COG0066	3-isopropylmalate dehydratase activity
HZT40_20590	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
HZT40_20595	COG0473	3-isopropylmalate dehydrogenase activity
HZT40_20630	COG0583	DNA-binding transcription factor activity
HZT40_20635	COG0745	RESPONSE REGULATOR receiver
HZT40_20680	COG1077	Cell shape determining protein MreB Mrl
HZT40_20690	COG4615	Cyclic peptide transporter
HZT40_20720	COG3597	protein domain associated with
HZT40_20725	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
HZT40_20760	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
HZT40_20775	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HZT40_20785	COG3002	Belongs to the UPF0753 family
HZT40_20795	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HZT40_20810	COG4191	Histidine kinase
HZT40_20925	COG3259	Nickel-dependent hydrogenase
HZT40_20930	COG1941	NADH ubiquinone oxidoreductase 20 kDa subunit
HZT40_20935	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
HZT40_20945	COG1162	GTPase activity
HZT40_20965	COG0625	glutathione transferase activity
HZT40_20985	COG0625	glutathione transferase activity
HZT40_20995	COG0456	acetyltransferase
HZT40_21020	COG2808	Putative FMN-binding domain
HZT40_21035	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HZT40_21065	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
HZT40_21090	COG3145	DNA-N1-methyladenine dioxygenase activity
HZT40_21100	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HZT40_21110	COG3077	Addiction module antitoxin, RelB DinJ family
HZT40_21120	COG1690	Belongs to the RtcB family
HZT40_21140	COG4650	regulator
HZT40_21150	COG0116	Belongs to the methyltransferase superfamily
HZT40_21150	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
HZT40_21170	COG0084	hydrolase, TatD family'
HZT40_21185	COG2918	glutathione biosynthetic process
HZT40_21190	COG0724	RNA recognition motif
HZT40_21195	COG1872	DUF167
HZT40_21200	COG0762	integral membrane protein
HZT40_21235	COG2046	Belongs to the sulfate adenylyltransferase family
HZT40_21250	COG0563	adenylate kinase activity
HZT40_21255	COG1047	Peptidyl-prolyl cis-trans
HZT40_21265	COG0205	6-phosphofructokinase activity
HZT40_21275	COG1116	anion transmembrane transporter activity
HZT40_21275	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HZT40_21285	COG2223	nitrite transmembrane transporter activity
HZT40_21295	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HZT40_21305	COG0243	molybdopterin cofactor binding
HZT40_21370	COG1696	Membrane protein involved in D-alanine export
HZT40_21385	COG2048	Heterodisulfide reductase, subunit B
HZT40_21400	COG1233	COG1233 Phytoene dehydrogenase and related
HZT40_21405	COG0123	including yeast histone deacetylase and acetoin utilization protein
HZT40_21410	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HZT40_21410	COG1042	CoA-binding domain protein
HZT40_21410	COG0045	succinate-CoA ligase (ADP-forming) activity
HZT40_21430	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
HZT40_21450	COG1385	rRNA (uridine-N3-)-methyltransferase activity
HZT40_21465	COG0330	HflC and HflK could
HZT40_21480	COG0745	RESPONSE REGULATOR receiver
HZT40_21485	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
HZT40_21495	COG0604	alcohol dehydrogenase
HZT40_21500	COG2755	lipolytic protein G-D-S-L family
HZT40_21500	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
HZT40_21505	COG0343	queuine tRNA-ribosyltransferase activity
HZT40_21540	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
HZT40_21540	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
HZT40_21545	COG0802	atpase or kinase
HZT40_21560	COG0009	L-threonylcarbamoyladenylate synthase
HZT40_21570	COG2210	Belongs to the sulfur carrier protein TusA family
HZT40_21580	COG1309	transcriptional regulator
HZT40_21590	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HZT40_21595	COG4221	oxidoreductase activity
HZT40_21600	COG0583	DNA-binding transcription factor activity
HZT40_21625	COG2205	protein histidine kinase activity
HZT40_21630	COG5002	protein histidine kinase activity
HZT40_21640	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HZT40_21645	COG2162	N-hydroxyarylamine O-acetyltransferase activity
HZT40_21655	COG1538	Outer membrane efflux protein
HZT40_21665	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
HZT40_21740	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HZT40_21745	COG2210	Belongs to the sulfur carrier protein TusA family
HZT40_21755	COG1408	metallophosphoesterase
HZT40_21775	COG0840	transmembrane signaling receptor activity
HZT40_21810	COG0643	Histidine kinase
HZT40_21810	COG2198	Histidine kinase
HZT40_21830	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
HZT40_21840	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
HZT40_21850	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
HZT40_21870	COG3956	TIGRFAM MazG family protein
HZT40_21885	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
HZT40_21890	COG0217	transcriptional regulatory protein
HZT40_21895	COG0746	molybdenum cofactor guanylyltransferase activity
HZT40_21915	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HZT40_21920	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
HZT40_21925	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
HZT40_21960	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HZT40_21970	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
HZT40_21990	COG3070	regulator of competence-specific genes
HZT40_22010	COG3070	regulator of competence-specific genes
HZT40_22015	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
HZT40_22035	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
HZT40_22055	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
HZT40_22065	COG0535	radical SAM domain protein
HZT40_22140	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
HZT40_22170	COG1131	(ABC) transporter
HZT40_22210	COG0126	phosphoglycerate kinase activity
HZT40_22215	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HZT40_22220	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
HZT40_22225	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
HZT40_22240	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
HZT40_22250	COG3228	Belongs to the MtfA family
HZT40_22265	COG2067	long-chain fatty acid transport protein
HZT40_22280	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
HZT40_22300	COG0732	type I restriction modification DNA specificity domain
HZT40_22330	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
HZT40_22335	COG2081	HI0933 family
HZT40_22355	COG3550	peptidyl-serine autophosphorylation
HZT40_22565	COG2885	chlorophyll binding
HZT40_22595	COG0811	peptide transport
HZT40_22605	COG2255	four-way junction helicase activity
HZT40_22610	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HZT40_22615	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HZT40_22650	COG1216	Glycosyl transferase, family 2
HZT40_22655	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
HZT40_22660	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HZT40_22700	COG4251	negative regulation of phosphorylation
HZT40_22700	COG3706	GGDEF domain
HZT40_22700	COG2203	Gaf domain
HZT40_22700	COG5001	Diguanylate cyclase
HZT40_22705	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HZT40_22715	COG1131	(ABC) transporter
HZT40_22755	COG0488	(ABC) transporter
HZT40_22760	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HZT40_22770	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
HZT40_22785	COG1283	sodium-dependent phosphate transmembrane transporter activity
HZT40_22800	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HZT40_22815	COG2204	response regulator
HZT40_22835	COG0174	glutamine synthetase
HZT40_22850	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
HZT40_22860	COG1611	Belongs to the LOG family
HZT40_22865	COG5007	Belongs to the BolA IbaG family
HZT40_22885	COG1317	bacterial-type flagellum organization
HZT40_22900	COG4789	Type iii secretion
HZT40_22910	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
HZT40_22925	COG4790	Type iii secretion
HZT40_22965	COG1560	Kdo2-lipid A biosynthetic process
HZT40_22980	COG0483	inositol monophosphate 1-phosphatase activity
HZT40_22985	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
HZT40_23005	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
HZT40_23015	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HZT40_23035	COG1607	acyl-coa hydrolase
HZT40_23050	COG0018	arginyl-trna synthetase
HZT40_23115	COG1187	pseudouridine synthase activity
HZT40_23120	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA