locus-tag	class	description
GT409_00010	COG2259	Doxx family
GT409_00020	COG0336	Belongs to the RNA methyltransferase TrmD family
GT409_00035	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
GT409_00045	COG2226	methyltransferase
GT409_00050	COG2890	protein-(glutamine-N5) methyltransferase activity
GT409_00055	COG1074	ATP-dependent DNA helicase activity
GT409_00070	COG3547	Transposase (IS116 IS110 IS902 family)
GT409_00075	COG3328	transposase activity
GT409_00080	COG0217	transcriptional regulatory protein
GT409_00085	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
GT409_00090	COG0740	serine-type endopeptidase activity
GT409_00095	COG0544	peptidyl-prolyl cis-trans isomerase activity
GT409_00120	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
GT409_00125	COG1872	DUF167
GT409_00135	COG1482	cell wall glycoprotein biosynthetic process
GT409_00140	COG0432	Pfam Uncharacterised protein family UPF0047
GT409_00150	COG0528	UMP kinase activity
GT409_00155	COG0233	cytoplasmic translational termination
GT409_00160	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
GT409_00195	COG1127	ABC transporter
GT409_00200	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
GT409_00220	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
GT409_00225	COG1404	Belongs to the peptidase S8 family
GT409_00230	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
GT409_00235	COG0215	cysteine-tRNA ligase activity
GT409_00255	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
GT409_00270	COG0438	transferase activity, transferring glycosyl groups
GT409_00285	COG1049	propionate catabolic process, 2-methylcitrate cycle
GT409_00295	COG2197	response regulator
GT409_00320	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
GT409_00325	COG3494	Protein of unknown function (DUF1009)
GT409_00345	COG0693	protein deglycase activity
GT409_00350	COG1597	lipid kinase activity
GT409_00355	COG0668	transmembrane transport
GT409_00360	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
GT409_00365	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
GT409_00370	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
GT409_00375	COG0768	penicillin binding
GT409_00385	COG0275	rRNA processing
GT409_00395	COG2001	Belongs to the MraZ family
GT409_00415	COG1959	2 iron, 2 sulfur cluster binding
GT409_00420	COG0138	bifunctional purine biosynthesis protein purh
GT409_00435	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
GT409_00455	COG0107	imidazoleglycerol-phosphate synthase activity
GT409_00460	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
GT409_00470	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
GT409_00475	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
GT409_00480	COG0445	tRNA wobble uridine modification
GT409_00485	COG0445	tRNA wobble uridine modification
GT409_00490	COG1966	Carbon starvation protein
GT409_00515	COG0745	RESPONSE REGULATOR receiver
GT409_00515	COG2205	protein histidine kinase activity
GT409_00515	COG3292	Two component regulator propeller
GT409_00520	COG5002	protein histidine kinase activity
GT409_00530	COG3119	arylsulfatase activity
GT409_00535	COG2211	Major facilitator Superfamily
GT409_00545	COG5434	Belongs to the glycosyl hydrolase 28 family
GT409_00550	COG2197	response regulator
GT409_00565	COG0383	alpha-mannosidase activity
GT409_00570	COG0383	alpha-mannosidase activity
GT409_00580	COG3119	arylsulfatase activity
GT409_00585	COG3119	arylsulfatase activity
GT409_00610	COG3119	arylsulfatase activity
GT409_00620	COG3119	arylsulfatase activity
GT409_00645	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
GT409_00650	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
GT409_00655	COG0534	Mate efflux family protein
GT409_00670	COG1538	Outer membrane efflux protein
GT409_00675	COG1309	transcriptional regulator
GT409_00695	COG3119	arylsulfatase activity
GT409_00710	COG4733	cellulase activity
GT409_00710	COG5297	Belongs to the glycosyl hydrolase family 6
GT409_00720	COG0673	inositol 2-dehydrogenase activity
GT409_00725	COG3119	arylsulfatase activity
GT409_00755	COG1486	melibiose metabolic process
GT409_00775	COG1175	transmembrane transport
GT409_00780	COG0395	ABC-type sugar transport system, permease component
GT409_00785	COG3842	ATPase activity
GT409_00800	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
GT409_00830	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
GT409_00845	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
GT409_00850	COG2239	Acts as a magnesium transporter
GT409_00855	COG1381	Involved in DNA repair and RecF pathway recombination
GT409_00880	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
GT409_00885	COG0297	glycogen (starch) synthase activity
GT409_00905	COG0724	RNA recognition motif
GT409_00910	COG0463	Glycosyl transferase, family 2
GT409_00920	COG1592	Rubrerythrin
GT409_00925	COG0564	pseudouridine synthase activity
GT409_00935	COG1573	uracil-dna glycosylase
GT409_00940	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
GT409_00945	COG0473	3-isopropylmalate dehydrogenase activity
GT409_00950	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
GT409_00955	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
GT409_00965	COG1132	(ABC) transporter
GT409_00985	COG1216	Glycosyl transferase, family 2
GT409_00985	COG0463	Glycosyl transferase, family 2
GT409_01000	COG0110	maltose O-acetyltransferase activity
GT409_01030	COG1663	tetraacyldisaccharide 4'-kinase activity
GT409_01035	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
GT409_01065	COG1704	LemA family
GT409_01075	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
GT409_01090	COG0668	transmembrane transport
GT409_01100	COG0438	transferase activity, transferring glycosyl groups
GT409_01105	COG0366	Alpha amylase catalytic
GT409_01135	COG0137	argininosuccinate synthase activity
GT409_01150	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
GT409_01160	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
GT409_01165	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
GT409_01170	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
GT409_01185	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
GT409_01195	COG0598	Magnesium transport protein CorA
GT409_01200	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
GT409_01205	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
GT409_01210	COG1028	Short-chain dehydrogenase reductase Sdr
GT409_01220	COG1136	(ABC) transporter
GT409_01230	COG0577	efflux transmembrane transporter activity
GT409_01245	COG3328	transposase activity
GT409_01275	COG0659	secondary active sulfate transmembrane transporter activity
GT409_01305	COG0288	reversible hydration of carbon dioxide
GT409_01315	COG0590	tRNA wobble adenosine to inosine editing
GT409_01340	COG1070	Carbohydrate kinase
GT409_01360	COG1131	(ABC) transporter
GT409_01410	COG0811	peptide transport
GT409_01430	COG0390	transport system, permease component
GT409_01435	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
GT409_01440	COG0129	dihydroxy-acid dehydratase activity
GT409_01445	COG0653	protein targeting
GT409_01450	COG1047	Peptidyl-prolyl cis-trans
GT409_01465	COG1692	metallophosphoesterase
GT409_01470	COG3132	Protein of unknown function, DUF480
GT409_01485	COG1722	exodeoxyribonuclease VII activity
GT409_01490	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
GT409_01495	COG0667	Aldo Keto reductase
GT409_01500	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
GT409_01500	COG0546	phosphoglycolate phosphatase activity
GT409_01520	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
GT409_01535	COG0706	membrane insertase activity
GT409_01540	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
GT409_01545	COG0594	ribonuclease P activity
GT409_01550	COG0230	Belongs to the bacterial ribosomal protein bL34 family
GT409_01555	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
GT409_01560	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
GT409_01570	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
GT409_01575	COG0517	IMP dehydrogenase activity
GT409_01575	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
GT409_01580	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
GT409_01600	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
GT409_01640	COG0556	nucleotide-excision repair
GT409_01650	COG3852	Histidine kinase
GT409_01655	COG0745	RESPONSE REGULATOR receiver
GT409_01660	COG0358	DNA primase activity
GT409_01670	COG1131	(ABC) transporter
GT409_01695	COG0195	Participates in both transcription termination and antitermination
GT409_01700	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
GT409_01705	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
GT409_01710	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
GT409_01715	COG0196	riboflavin kinase activity
GT409_01725	COG0237	dephospho-CoA kinase activity
GT409_01735	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
GT409_01740	COG0438	transferase activity, transferring glycosyl groups
GT409_01760	COG2201	protein-glutamate methylesterase activity
GT409_01780	COG0439	Biotin carboxylase
GT409_01785	COG0511	ligase activity, forming carbon-carbon bonds
GT409_01790	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
GT409_01795	COG0024	Methionine aminopeptidase
GT409_01800	COG0563	adenylate kinase activity
GT409_01815	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
GT409_01820	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
GT409_01830	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
GT409_01835	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
GT409_01840	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
GT409_01845	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
GT409_01855	COG0255	Belongs to the universal ribosomal protein uL29 family
GT409_01860	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
GT409_01865	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
GT409_01870	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
GT409_01875	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
GT409_01880	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
GT409_01885	COG0089	rRNA binding
GT409_01890	COG0088	Forms part of the polypeptide exit tunnel
GT409_01895	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
GT409_01900	COG0051	transcription antitermination factor activity, RNA binding
GT409_01905	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
GT409_01910	COG0049	tRNA binding
GT409_01915	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
GT409_01925	COG3869	Catalyzes the specific phosphorylation of arginine residues in
GT409_01940	COG1136	(ABC) transporter
GT409_01950	COG4591	ABC-type transport system involved in lipoprotein release permease component
GT409_01960	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
GT409_01965	COG1032	radical SAM domain protein
GT409_01970	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
GT409_01975	COG0022	dehydrogenase e1 component
GT409_01980	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
GT409_01990	COG2211	Major facilitator Superfamily
GT409_02015	COG3119	arylsulfatase activity
GT409_02020	COG3119	arylsulfatase activity
GT409_02025	COG0673	inositol 2-dehydrogenase activity
GT409_02040	COG1609	Transcriptional regulator
GT409_02050	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
GT409_02055	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
GT409_02085	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
GT409_02085	COG0574	Belongs to the PEP-utilizing enzyme family
GT409_02110	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
GT409_02125	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
GT409_02145	COG0716	FMN binding
GT409_02160	COG1730	sister chromatid segregation
GT409_02180	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
GT409_02210	COG1321	iron dependent repressor
GT409_02230	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
GT409_02245	COG3201	nicotinamide mononucleotide transporter
GT409_02260	COG0778	Nitroreductase
GT409_02260	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
GT409_02265	COG3458	cephalosporin-C deacetylase activity
GT409_02270	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
GT409_02290	COG0800	Aldolase
GT409_02295	COG0095	Lipoate-protein ligase
GT409_02335	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
GT409_02340	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
GT409_02340	COG0047	phosphoribosylformylglycinamidine synthase activity
GT409_02345	COG1108	ABC-type Mn2 Zn2 transport systems permease components
GT409_02350	COG1121	(ABC) transporter
GT409_02355	COG0803	Belongs to the bacterial solute-binding protein 9 family
GT409_02370	COG3634	alkyl hydroperoxide reductase activity
GT409_02390	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
GT409_02395	COG2233	PERMEase
GT409_02400	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
GT409_02415	COG2252	PERMEase
GT409_02420	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
GT409_02430	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
GT409_02435	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
GT409_02440	COG2183	response to ionizing radiation
GT409_02465	COG3119	arylsulfatase activity
GT409_02470	COG2273	Hydrolase Family 16
GT409_02485	COG3119	arylsulfatase activity
GT409_02490	COG3408	Glycogen debranching enzyme
GT409_02490	COG3119	arylsulfatase activity
GT409_02510	COG3119	arylsulfatase activity
GT409_02540	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
GT409_02545	COG4977	sequence-specific DNA binding
GT409_02575	COG1012	belongs to the aldehyde dehydrogenase family
GT409_02575	COG1454	alcohol dehydrogenase
GT409_02600	COG2211	Major facilitator Superfamily
GT409_02620	COG1414	Transcriptional regulator
GT409_02630	COG0385	Bile acid
GT409_02640	COG0501	Belongs to the peptidase M48B family
GT409_02645	COG1714	RDD family
GT409_02675	COG0714	Associated with various cellular activities
GT409_02695	COG1028	Short-chain dehydrogenase reductase Sdr
GT409_02705	COG0646	methionine synthase
GT409_02705	COG1410	methionine synthase
GT409_02715	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
GT409_02800	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
GT409_02805	COG1254	Belongs to the acylphosphatase family
GT409_02810	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
GT409_02820	COG2165	general secretion pathway protein
GT409_02830	COG1187	pseudouridine synthase activity
GT409_02835	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
GT409_02840	COG0085	RNA polymerase activity
GT409_02845	COG0222	ribosome binding
GT409_02855	COG0081	regulation of translation
GT409_02860	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
GT409_02870	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
GT409_02880	COG0267	Belongs to the bacterial ribosomal protein bL33 family
GT409_02885	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
GT409_02895	COG0450	alkyl hydroperoxide reductase
GT409_02900	COG0165	Argininosuccinate lyase
GT409_02905	COG1490	D-aminoacyl-tRNA deacylase activity
GT409_02915	COG0142	geranyltranstransferase activity
GT409_02930	COG4191	Histidine kinase
GT409_02955	COG0261	This protein binds to 23S rRNA in the presence of protein L20
GT409_02960	COG0211	Belongs to the bacterial ribosomal protein bL27 family
GT409_02965	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
GT409_03100	COG3254	rhamnose metabolic process
GT409_03105	COG2211	Major facilitator Superfamily
GT409_03110	COG3119	arylsulfatase activity
GT409_03120	COG3119	arylsulfatase activity
GT409_03130	COG3119	arylsulfatase activity
GT409_03135	COG3119	arylsulfatase activity
GT409_03140	COG3119	arylsulfatase activity
GT409_03150	COG3119	arylsulfatase activity
GT409_03165	COG3119	arylsulfatase activity
GT409_03170	COG3119	arylsulfatase activity
GT409_03175	COG3119	arylsulfatase activity
GT409_03180	COG0012	GTP binding
GT409_03185	COG0514	ATP-dependent DNA helicase (RecQ)
GT409_03200	COG0277	FAD linked oxidase domain protein
GT409_03220	COG1994	Peptidase M50
GT409_03235	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
GT409_03245	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
GT409_03250	COG0305	Participates in initiation and elongation during chromosome replication
GT409_03255	COG0359	binds to the 23S rRNA
GT409_03260	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
GT409_03265	COG0629	single-stranded DNA binding
GT409_03275	COG0193	aminoacyl-tRNA hydrolase activity
GT409_03280	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
GT409_03285	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
GT409_03305	COG0811	peptide transport
GT409_03330	COG0246	Mannitol dehydrogenase
GT409_03335	COG1070	Carbohydrate kinase
GT409_03350	COG2207	Transcriptional regulator
GT409_03375	COG0385	Bile acid
GT409_03380	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
GT409_03385	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
GT409_03395	COG1917	Cupin 2, conserved barrel domain protein
GT409_03395	COG4977	sequence-specific DNA binding
GT409_03405	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GT409_03425	COG0395	ABC-type sugar transport system, permease component
GT409_03430	COG1175	transmembrane transport
GT409_03440	COG3119	arylsulfatase activity
GT409_03465	COG3250	beta-galactosidase activity
GT409_03470	COG4753	response regulator
GT409_03470	COG2207	Transcriptional regulator
GT409_03480	COG3842	ATPase activity
GT409_03490	COG3119	arylsulfatase activity
GT409_03505	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
GT409_03510	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
GT409_03515	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
GT409_03525	COG0564	pseudouridine synthase activity
GT409_03530	COG0436	Aminotransferase
GT409_03535	COG1522	sequence-specific DNA binding
GT409_03545	COG0347	Belongs to the P(II) protein family
GT409_03550	COG0004	ammonium transporteR
GT409_03555	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
GT409_03560	COG0189	ligase activity
GT409_03565	COG0189	ligase activity
GT409_03565	COG4067	protein conserved in archaea
GT409_03570	COG1363	Peptidase, m42
GT409_03575	COG0220	tRNA (guanine-N7-)-methyltransferase activity
GT409_03590	COG0730	response to heat
GT409_03645	COG0501	Belongs to the peptidase M48B family
GT409_03650	COG1704	LemA family
GT409_03660	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
GT409_03660	COG3976	FMN-binding domain protein
GT409_03665	COG0129	dihydroxy-acid dehydratase activity
GT409_03695	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
GT409_03750	COG0113	porphobilinogen synthase activity
GT409_03765	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
GT409_03775	COG0535	radical SAM domain protein
GT409_03780	COG0535	radical SAM domain protein
GT409_03785	COG0714	Associated with various cellular activities
GT409_03815	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
GT409_03820	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
GT409_03830	COG2954	triphosphatase activity
GT409_03835	COG0284	orotidine-5'-phosphate decarboxylase activity
GT409_03845	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
GT409_03850	COG0640	Transcriptional regulator
GT409_03855	COG1592	Rubrerythrin
GT409_03855	COG1773	rubredoxin
GT409_03870	COG1720	tRNA m6t6A37 methyltransferase activity
GT409_03880	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
GT409_03880	COG3170	Tfp pilus assembly protein FimV
GT409_03885	COG2207	Transcriptional regulator
GT409_03890	COG2226	methyltransferase
GT409_03920	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
GT409_03925	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
GT409_03935	COG1132	(ABC) transporter
GT409_03940	COG1132	(ABC) transporter
GT409_03945	COG3119	arylsulfatase activity
GT409_03950	COG1609	Transcriptional regulator
GT409_03950	COG2207	Transcriptional regulator
GT409_03995	COG0557	exoribonuclease II activity
GT409_04005	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
GT409_04010	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
GT409_04020	COG1971	Probably functions as a manganese efflux pump
GT409_04050	COG0728	peptidoglycan biosynthetic process
GT409_04085	COG0456	acetyltransferase
GT409_04085	COG1214	PFAM Peptidase M22, glycoprotease
GT409_04090	COG1509	lysine 2,3-aminomutase activity
GT409_04095	COG1511	domain protein
GT409_04095	COG3264	Mechanosensitive ion channel
GT409_04110	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
GT409_04120	COG0473	3-isopropylmalate dehydrogenase activity
GT409_04170	COG3547	Transposase (IS116 IS110 IS902 family)
GT409_04200	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GT409_04200	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GT409_04210	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
GT409_04220	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
GT409_04255	COG4977	sequence-specific DNA binding
GT409_04275	COG3119	arylsulfatase activity
GT409_04280	COG3119	arylsulfatase activity
GT409_04285	COG3119	arylsulfatase activity
GT409_04295	COG2207	Transcriptional regulator
GT409_04295	COG1609	Transcriptional regulator
GT409_04330	COG2211	Major facilitator Superfamily
GT409_04345	COG3119	arylsulfatase activity
GT409_04355	COG3119	arylsulfatase activity
GT409_04365	COG3119	arylsulfatase activity
GT409_04380	COG3119	arylsulfatase activity
GT409_04390	COG3119	arylsulfatase activity
GT409_04395	COG3119	arylsulfatase activity
GT409_04405	COG1609	Transcriptional regulator
GT409_04410	COG2211	Major facilitator Superfamily
GT409_04415	COG3250	beta-galactosidase activity
GT409_04420	COG3119	arylsulfatase activity
GT409_04460	COG3547	Transposase (IS116 IS110 IS902 family)
GT409_04485	COG3547	Transposase (IS116 IS110 IS902 family)
GT409_04490	COG3328	transposase activity
GT409_04510	COG3328	transposase activity
GT409_04575	COG3119	arylsulfatase activity
GT409_04580	COG1609	Transcriptional regulator
GT409_04605	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
GT409_04615	COG1643	Atp-dependent helicase
GT409_04650	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
GT409_04655	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
GT409_04695	COG0732	type I restriction modification DNA specificity domain
GT409_04700	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
GT409_04730	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
GT409_04755	COG0366	Alpha amylase catalytic
GT409_04805	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
GT409_04810	COG0800	Aldolase
GT409_04815	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GT409_04820	COG1609	Transcriptional regulator
GT409_04820	COG2207	Transcriptional regulator
GT409_04825	COG1028	Short-chain dehydrogenase reductase Sdr
GT409_04830	COG1904	glucuronate isomerase
GT409_04845	COG0318	PFAM AMP-dependent synthetase and ligase
GT409_04855	COG1994	Peptidase M50
GT409_04865	COG1929	Belongs to the glycerate kinase type-1 family
GT409_04880	COG1519	Transferase
GT409_04885	COG4974	Belongs to the 'phage' integrase family
GT409_04895	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
GT409_04900	COG0758	DNA mediated transformation
GT409_04900	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
GT409_04910	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
GT409_04925	COG1214	PFAM Peptidase M22, glycoprotease
GT409_04945	COG2234	aminopeptidase activity
GT409_04950	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
GT409_04980	COG0488	(ABC) transporter
GT409_04985	COG3022	response to hydroperoxide
GT409_04990	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
GT409_05010	COG3119	arylsulfatase activity
GT409_05025	COG3119	arylsulfatase activity
GT409_05030	COG3119	arylsulfatase activity
GT409_05035	COG3250	beta-galactosidase activity
GT409_05040	COG3119	arylsulfatase activity
GT409_05050	COG3119	arylsulfatase activity
GT409_05070	COG1609	Transcriptional regulator
GT409_05085	COG3940	Belongs to the glycosyl hydrolase 43 family
GT409_05105	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
GT409_05115	COG3228	Belongs to the MtfA family
GT409_05120	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
GT409_05125	COG0134	indole-3-glycerol-phosphate synthase activity
GT409_05130	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
GT409_05145	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
GT409_05155	COG0194	GDP metabolic process
GT409_05165	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
GT409_05170	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GT409_05180	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
GT409_05200	COG0658	competence protein
GT409_05200	COG2333	competence protein COMEC
GT409_05220	COG2221	Nitrite and sulphite reductase 4Fe-4S
GT409_05225	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
GT409_05230	COG0475	glutathione-regulated potassium exporter activity
GT409_05235	COG0531	amino acid
GT409_05245	COG2264	protein methyltransferase activity
GT409_05250	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GT409_05260	COG0747	negative chemotaxis
GT409_05265	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
GT409_05270	COG0149	triose-phosphate isomerase activity
GT409_05275	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
GT409_05280	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
GT409_05285	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
GT409_05295	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
GT409_05300	COG0463	Glycosyl transferase, family 2
GT409_05315	COG0732	type I restriction modification DNA specificity domain
GT409_05320	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
GT409_05325	COG3177	Filamentation induced by cAMP protein fic
GT409_05330	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
GT409_05365	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
GT409_05370	COG0151	Belongs to the GarS family
GT409_05385	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
GT409_05390	COG0483	inositol monophosphate 1-phosphatase activity
GT409_05400	COG0009	L-threonylcarbamoyladenylate synthase
GT409_05405	COG3425	synthase
GT409_05425	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
GT409_05425	COG2207	Transcriptional regulator
GT409_05430	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
GT409_05465	COG3119	arylsulfatase activity
GT409_05475	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
GT409_05480	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
GT409_05530	COG0811	peptide transport
GT409_05550	COG1215	transferase activity, transferring glycosyl groups
GT409_05560	COG0640	Transcriptional regulator
GT409_05585	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
GT409_05605	COG4452	Inner membrane protein CreD
GT409_05620	COG0191	fructose-bisphosphate aldolase activity
GT409_05635	COG1115	amino acid carrier protein
GT409_05675	COG0606	chelatase, subunit chli
GT409_05685	COG1566	PFAM secretion protein HlyD family protein
GT409_05690	COG1136	(ABC) transporter
GT409_05690	COG0577	efflux transmembrane transporter activity
GT409_05725	COG2176	DNA-directed DNA polymerase activity
GT409_05735	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
GT409_05740	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
GT409_05745	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
GT409_05755	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
GT409_05755	COG0731	radical SAM domain protein
GT409_05760	COG0254	rRNA binding
GT409_05765	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
GT409_05780	COG1272	protein, Hemolysin III
GT409_05790	COG0445	tRNA wobble uridine modification
GT409_05795	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
GT409_05800	COG1160	GTP binding
GT409_05805	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
GT409_05825	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
GT409_05830	COG1217	gtp-binding protein TYPA
GT409_05855	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
GT409_05870	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
GT409_05885	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
GT409_05890	COG0592	DNA-directed DNA polymerase activity
GT409_05925	COG3344	reverse transcriptase
GT409_05945	COG1683	Conserved Protein
GT409_05960	COG1151	hydroxylamine reductase activity
GT409_05965	COG2116	formate transmembrane transporter activity
GT409_05970	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
GT409_05975	COG2226	methyltransferase
GT409_05985	COG3189	MarR family transcriptional regulator
GT409_06035	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
GT409_06040	COG0492	ferredoxin-NADP+ reductase activity
GT409_06045	COG1960	acyl-CoA dehydrogenase activity
GT409_06050	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
GT409_06085	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
GT409_06110	COG0488	(ABC) transporter
GT409_06115	COG0513	Belongs to the DEAD box helicase family
GT409_06125	COG0495	leucyl-tRNA aminoacylation
GT409_06140	COG1609	Transcriptional regulator
GT409_06175	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
GT409_06210	COG3119	arylsulfatase activity
GT409_06210	COG3408	Glycogen debranching enzyme
GT409_06215	COG3119	arylsulfatase activity
GT409_06235	COG1295	ribonuclease BN
GT409_06320	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
GT409_06320	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
GT409_06330	COG1448	Aminotransferase
GT409_06340	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
GT409_06345	COG0805	protein transport
GT409_06350	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
GT409_06360	COG2211	Major facilitator Superfamily
GT409_06375	COG3459	Glycosyltransferase 36 associated
GT409_06380	COG3459	Glycosyltransferase 36 associated
GT409_06385	COG3119	arylsulfatase activity
GT409_06400	COG3119	arylsulfatase activity
GT409_06410	COG3119	arylsulfatase activity
GT409_06425	COG3119	arylsulfatase activity
GT409_06430	COG0662	Cupin 2, conserved barrel domain protein
GT409_06430	COG2207	Transcriptional regulator
GT409_06435	COG3119	arylsulfatase activity
GT409_06480	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
GT409_06485	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
GT409_06495	COG4977	sequence-specific DNA binding
GT409_06495	COG1917	Cupin 2, conserved barrel domain protein
GT409_06510	COG0363	glucosamine-6-phosphate deaminase activity
GT409_06575	COG1609	Transcriptional regulator
GT409_06575	COG2207	Transcriptional regulator
GT409_06595	COG3408	Glycogen debranching enzyme
GT409_06595	COG3119	arylsulfatase activity
GT409_06600	COG3119	arylsulfatase activity
GT409_06615	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
GT409_06620	COG3250	beta-galactosidase activity
GT409_06645	COG1609	Transcriptional regulator
GT409_06655	COG5434	Belongs to the glycosyl hydrolase 28 family
GT409_06665	COG3119	arylsulfatase activity
GT409_06680	COG3250	beta-galactosidase activity
GT409_06685	COG2211	Major facilitator Superfamily
GT409_06695	COG1609	Transcriptional regulator
GT409_06695	COG2207	Transcriptional regulator
GT409_06710	COG0366	Alpha amylase catalytic
GT409_06720	COG2188	Transcriptional regulator
GT409_06725	COG1472	Belongs to the glycosyl hydrolase 3 family
GT409_06730	COG2211	Major facilitator Superfamily
GT409_06740	COG3119	arylsulfatase activity
GT409_06785	COG3119	arylsulfatase activity
GT409_06790	COG1368	sulfuric ester hydrolase activity
GT409_06795	COG3119	arylsulfatase activity
GT409_06830	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
GT409_06840	COG1609	Transcriptional regulator
GT409_06865	COG3119	arylsulfatase activity
GT409_06870	COG3119	arylsulfatase activity
GT409_06885	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
GT409_06895	COG1674	ftsk spoiiie
GT409_06920	COG0826	peptidase U32
GT409_06940	COG3530	Putative quorum-sensing-regulated virulence factor
GT409_06960	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
GT409_06965	COG1156	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit
GT409_06990	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
GT409_07000	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
GT409_07000	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
GT409_07020	COG3119	arylsulfatase activity
GT409_07035	COG3119	arylsulfatase activity
GT409_07045	COG1414	Transcriptional regulator
GT409_07060	COG2885	chlorophyll binding
GT409_07065	COG0823	Involved in the tonB-independent uptake of proteins
GT409_07085	COG0811	peptide transport
GT409_07105	COG0668	transmembrane transport
GT409_07110	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
GT409_07115	COG0493	'glutamate synthase
GT409_07140	COG0513	Belongs to the DEAD box helicase family
GT409_07155	COG3411	Ferredoxin
GT409_07160	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
GT409_07185	COG1119	ATPase activity
GT409_07190	COG0133	tryptophan synthase activity
GT409_07200	COG1561	YicC-like family, N-terminal region
GT409_07205	COG0784	Response regulator, receiver
GT409_07205	COG4191	Histidine kinase
GT409_07220	COG0632	four-way junction helicase activity
GT409_07225	COG2255	four-way junction helicase activity
GT409_07235	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
GT409_07255	COG0004	ammonium transporteR
GT409_07260	COG0347	Belongs to the P(II) protein family
GT409_07270	COG0084	hydrolase, TatD family'
GT409_07275	COG0268	Binds directly to 16S ribosomal RNA
GT409_07280	COG0828	Belongs to the bacterial ribosomal protein bS21 family
GT409_07285	COG0733	neurotransmitter:sodium symporter activity
GT409_07290	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
GT409_07300	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
GT409_07305	COG1185	polyribonucleotide nucleotidyltransferase activity
GT409_07425	COG0673	inositol 2-dehydrogenase activity
GT409_07440	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
GT409_07450	COG3708	Transcriptional regulator
GT409_07450	COG2207	Transcriptional regulator
GT409_07480	COG0366	Alpha amylase catalytic
GT409_07485	COG0438	transferase activity, transferring glycosyl groups
GT409_07500	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
GT409_07510	COG1215	transferase activity, transferring glycosyl groups
GT409_07525	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
GT409_07535	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
GT409_07555	COG1283	sodium-dependent phosphate transmembrane transporter activity
GT409_07570	COG0708	Exodeoxyribonuclease III
GT409_07575	COG3119	arylsulfatase activity
GT409_07630	COG3119	arylsulfatase activity
GT409_07635	COG1472	Belongs to the glycosyl hydrolase 3 family
GT409_07645	COG1609	Transcriptional regulator
GT409_07680	COG0423	glycine-tRNA ligase activity
GT409_07690	COG1166	arginine decarboxylase activity
GT409_07700	COG2081	HI0933 family
GT409_07710	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
GT409_07745	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
GT409_07780	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
GT409_07805	COG0543	2 iron, 2 sulfur cluster binding
GT409_07810	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
GT409_07825	COG1747	RNA polymerase binding
GT409_07825	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
GT409_07830	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
GT409_07840	COG2824	Alkylphosphonate utilization operon protein PhnA
GT409_07855	COG0067	glutamate synthase
GT409_07855	COG0070	glutamate synthase
GT409_07855	COG0069	glutamate synthase activity
GT409_07890	COG0534	Mate efflux family protein
GT409_07955	COG0069	glutamate synthase activity
GT409_07975	COG0126	phosphoglycerate kinase activity
GT409_07990	COG3119	arylsulfatase activity
GT409_07995	COG4692	amylo-alpha-1,6-glucosidase activity
GT409_08005	COG1609	Transcriptional regulator
GT409_08010	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
GT409_08015	COG0673	inositol 2-dehydrogenase activity
GT409_08035	COG3119	arylsulfatase activity
GT409_08040	COG0657	acetylesterase activity
GT409_08060	COG3119	arylsulfatase activity
GT409_08065	COG1609	Transcriptional regulator
GT409_08075	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
GT409_08080	COG0673	inositol 2-dehydrogenase activity
GT409_08115	COG1069	ribulokinase activity
GT409_08125	COG2207	Transcriptional regulator
GT409_08135	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
GT409_08140	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
GT409_08155	COG3119	arylsulfatase activity
GT409_08175	COG2207	Transcriptional regulator
GT409_08210	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
GT409_08285	COG0646	methionine synthase
GT409_08285	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
GT409_08310	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GT409_08315	COG0489	protein tyrosine kinase activity
GT409_08325	COG0489	protein tyrosine kinase activity
GT409_08350	COG1342	Belongs to the UPF0251 family
GT409_08360	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
GT409_08360	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
GT409_08370	COG2226	methyltransferase
GT409_08395	COG0686	Belongs to the AlaDH PNT family
GT409_08400	COG1943	Transposase
GT409_08420	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
GT409_08420	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
GT409_08430	COG0475	glutathione-regulated potassium exporter activity
GT409_08435	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GT409_08435	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GT409_08435	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
GT409_08440	COG0776	regulation of translation
GT409_08445	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
GT409_08485	COG1979	alcohol dehydrogenase
GT409_08490	COG2207	Transcriptional regulator
GT409_08500	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
GT409_08510	COG0037	tRNA processing
GT409_08520	COG0793	Belongs to the peptidase S41A family
GT409_08525	COG0352	thiamine-phosphate diphosphorylase activity
GT409_08545	COG2022	thiamine diphosphate biosynthetic process
GT409_08570	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
GT409_08575	COG1418	mRNA catabolic process
GT409_08580	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
GT409_08600	COG0072	phenylalanine-tRNA ligase activity
GT409_08605	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
GT409_08605	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
GT409_08620	COG3123	guanosine phosphorylase activity
GT409_08630	COG0656	L-ascorbic acid biosynthetic process
GT409_08640	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
GT409_08645	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
GT409_08650	COG0518	GMP synthase (glutamine-hydrolyzing) activity
GT409_08650	COG0519	Catalyzes the synthesis of GMP from XMP
GT409_08655	COG0505	Belongs to the CarA family
GT409_08685	COG3956	TIGRFAM MazG family protein
GT409_08690	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
GT409_08770	COG3177	Filamentation induced by cAMP protein fic
GT409_08780	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
GT409_08800	COG1192	Involved in chromosome partitioning
GT409_08810	COG0484	heat shock protein binding
GT409_08815	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
GT409_08820	COG0071	Belongs to the small heat shock protein (HSP20) family
GT409_08835	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
GT409_08840	COG0424	maF-like protein
GT409_08850	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
GT409_08850	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
GT409_08855	COG0516	GMP reductase activity
GT409_08865	COG1454	alcohol dehydrogenase
GT409_08875	COG1355	regulation of microtubule-based process
GT409_08885	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
GT409_08890	COG0257	Belongs to the bacterial ribosomal protein bL36 family
GT409_08895	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
GT409_08900	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
GT409_08905	COG0202	RNA polymerase activity
GT409_08910	COG0203	ribosomal protein L17
GT409_08915	COG0280	phosphate acetyltransferase
GT409_08920	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
GT409_08935	COG0180	Tryptophanyl-tRNA synthetase
GT409_08940	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
GT409_08945	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
GT409_08950	COG1605	Chorismate mutase
GT409_08950	COG0077	Prephenate dehydratase
GT409_08955	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
GT409_08970	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
GT409_08975	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
GT409_08985	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
GT409_08995	COG0333	Belongs to the bacterial ribosomal protein bL32 family
GT409_09000	COG0416	fatty acid biosynthetic process
GT409_09005	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
GT409_09010	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
GT409_09015	COG2205	protein histidine kinase activity
GT409_09020	COG0745	RESPONSE REGULATOR receiver
GT409_09035	COG2226	methyltransferase
GT409_09080	COG4191	Histidine kinase
GT409_09080	COG0784	Response regulator, receiver
GT409_09100	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
GT409_09105	COG1450	Type ii and iii secretion system protein
GT409_09115	COG1136	(ABC) transporter
GT409_09120	COG0577	efflux transmembrane transporter activity
GT409_09120	COG1136	(ABC) transporter
GT409_09125	COG1546	Belongs to the CinA family
GT409_09125	COG1058	Belongs to the CinA family
GT409_09135	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
GT409_09160	COG2985	domain, Protein
GT409_09160	COG0490	domain, Protein
GT409_09170	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
GT409_09185	COG0602	queuosine metabolic process
GT409_09200	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
GT409_09205	COG2957	Belongs to the agmatine deiminase family
GT409_09210	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
GT409_09220	COG1472	Belongs to the glycosyl hydrolase 3 family
GT409_09230	COG0512	Glutamine amidotransferase of anthranilate synthase
GT409_09235	COG2154	pterin-4-alpha-carbinolamine dehydratase
GT409_09240	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
GT409_09245	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
GT409_09250	COG2204	response regulator
GT409_09255	COG4191	Histidine kinase
GT409_09260	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
GT409_09285	COG0232	Belongs to the dGTPase family. Type 2 subfamily
GT409_09290	COG0860	N-Acetylmuramoyl-L-alanine amidase
GT409_09300	COG0674	pyruvate-flavodoxin oxidoreductase activity
GT409_09300	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
GT409_09300	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
GT409_09300	COG1013	pyruvate-flavodoxin oxidoreductase activity
GT409_09315	COG0300	oxidoreductase activity
GT409_09335	COG4566	intracellular signal transduction
GT409_09345	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
GT409_09350	COG4191	Histidine kinase
GT409_09355	COG5000	phosphorelay sensor kinase activity
GT409_09360	COG0745	RESPONSE REGULATOR receiver
GT409_09365	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
GT409_09370	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
GT409_09390	COG2195	Cleaves the N-terminal amino acid of tripeptides
GT409_09395	COG0318	PFAM AMP-dependent synthetase and ligase
GT409_09400	COG1162	GTPase activity
GT409_09405	COG0504	CTP synthase activity
GT409_09420	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
GT409_09425	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
GT409_09425	COG0517	IMP dehydrogenase activity
GT409_09435	COG2264	protein methyltransferase activity
GT409_09450	COG1643	Atp-dependent helicase
GT409_09465	COG0527	aspartate kinase activity
GT409_09470	COG0444	Belongs to the ABC transporter superfamily
GT409_09480	COG4608	Belongs to the ABC transporter superfamily
GT409_09495	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
GT409_09495	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
GT409_09500	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
GT409_09500	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
GT409_09525	COG1187	pseudouridine synthase activity
GT409_09560	COG1518	maintenance of DNA repeat elements
GT409_09565	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
GT409_09595	COG0404	The glycine cleavage system catalyzes the degradation of glycine
GT409_09600	COG1331	Highly conserved protein containing a thioredoxin domain
GT409_09605	COG5002	protein histidine kinase activity
GT409_09605	COG0784	Response regulator, receiver
GT409_09605	COG2205	protein histidine kinase activity
GT409_09610	COG2201	protein-glutamate methylesterase activity
GT409_09625	COG0840	transmembrane signaling receptor activity
GT409_09640	COG0835	chemotaxis
GT409_09645	COG0657	acetylesterase activity
GT409_09645	COG2755	lipolytic protein G-D-S-L family
GT409_09670	COG3408	Glycogen debranching enzyme
GT409_09670	COG3119	arylsulfatase activity
GT409_09680	COG3119	arylsulfatase activity
GT409_09690	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
GT409_09695	COG3119	arylsulfatase activity
GT409_09715	COG0383	alpha-mannosidase activity
GT409_09720	COG3119	arylsulfatase activity
GT409_09735	COG1609	Transcriptional regulator
GT409_09745	COG0617	tRNA 3'-terminal CCA addition
GT409_09765	COG1528	Iron-storage protein
GT409_09770	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
GT409_09780	COG0436	Aminotransferase
GT409_09795	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
GT409_09800	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
GT409_09810	COG0772	Belongs to the SEDS family
GT409_09820	COG0798	PFAM Bile acid sodium symporter
GT409_09830	COG3118	belongs to the thioredoxin family
GT409_09840	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
GT409_09855	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
GT409_09875	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
GT409_09890	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
GT409_09900	COG0316	Belongs to the HesB IscA family
GT409_09910	COG0719	Fe-S assembly protein
GT409_09915	COG0396	ATPase activity
GT409_09920	COG0719	Fe-S assembly protein
GT409_09925	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
GT409_09930	COG0822	iron-sulfur transferase activity
GT409_09935	COG0489	protein tyrosine kinase activity
GT409_09945	COG1262	PFAM Formylglycine-generating sulfatase enzyme
GT409_09955	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
GT409_09970	COG1584	GPR1 FUN34 yaaH family protein
GT409_09975	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
GT409_09985	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
GT409_09990	COG0820	rRNA (adenine-C2-)-methyltransferase activity
GT409_09995	COG2304	oxidoreductase activity
GT409_10005	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
GT409_10010	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
GT409_10015	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
GT409_10020	COG0367	asparagine synthase
GT409_10030	COG0318	PFAM AMP-dependent synthetase and ligase
GT409_10040	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
GT409_10055	COG3119	arylsulfatase activity
GT409_10070	COG1917	Cupin 2, conserved barrel domain protein
GT409_10070	COG2207	Transcriptional regulator
GT409_10085	COG3119	arylsulfatase activity
GT409_10090	COG1472	Belongs to the glycosyl hydrolase 3 family
GT409_10115	COG3408	Glycogen debranching enzyme
GT409_10130	COG3940	Belongs to the glycosyl hydrolase 43 family
GT409_10135	COG3119	arylsulfatase activity
GT409_10140	COG2211	Major facilitator Superfamily
GT409_10145	COG3119	arylsulfatase activity
GT409_10155	COG3119	arylsulfatase activity
GT409_10160	COG3119	arylsulfatase activity
GT409_10165	COG3119	arylsulfatase activity
GT409_10175	COG2207	Transcriptional regulator
GT409_10175	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
GT409_10180	COG1609	Transcriptional regulator
GT409_10195	COG3119	arylsulfatase activity
GT409_10200	COG3119	arylsulfatase activity
GT409_10205	COG3119	arylsulfatase activity
GT409_10235	COG2211	Major facilitator Superfamily
GT409_10275	COG3119	arylsulfatase activity
GT409_10280	COG5434	Belongs to the glycosyl hydrolase 28 family
GT409_10290	COG3119	arylsulfatase activity
GT409_10310	COG2211	Major facilitator Superfamily
GT409_10320	COG3119	arylsulfatase activity
GT409_10325	COG4692	amylo-alpha-1,6-glucosidase activity
GT409_10340	COG2731	YhcH YjgK YiaL family protein
GT409_10355	COG1940	carbohydrate kinase activity
GT409_10360	COG3119	arylsulfatase activity
GT409_10400	COG0383	alpha-mannosidase activity
GT409_10410	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
GT409_10425	COG3119	arylsulfatase activity
GT409_10570	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
GT409_10580	COG0635	Involved in the biosynthesis of porphyrin-containing compound
GT409_10585	COG0227	Belongs to the bacterial ribosomal protein bL28 family
GT409_10590	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
GT409_10595	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
GT409_10600	COG0372	Belongs to the citrate synthase family
GT409_10620	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
GT409_10625	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
GT409_10635	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
GT409_10640	COG1027	Aspartate ammonia-lyase
GT409_10665	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
GT409_10675	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
GT409_10685	COG4191	Histidine kinase
GT409_10690	COG2204	response regulator
GT409_10700	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
GT409_10715	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
GT409_10725	COG2095	MarC family integral membrane protein
GT409_10730	COG1196	nuclear chromosome segregation
GT409_10745	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
GT409_10755	COG0720	synthase
GT409_10760	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
GT409_10770	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
GT409_10780	COG3328	transposase activity
GT409_10805	COG0446	pyridine nucleotide-disulphide oxidoreductase
GT409_10810	COG0826	peptidase U32
GT409_10820	COG0513	Belongs to the DEAD box helicase family
GT409_10830	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
GT409_10835	COG0291	Belongs to the bacterial ribosomal protein bL35 family
GT409_10840	COG1045	serine acetyltransferase
GT409_10860	COG0383	alpha-mannosidase activity
GT409_10870	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
GT409_10890	COG1609	Transcriptional regulator
GT409_10895	COG5434	Belongs to the glycosyl hydrolase 28 family
GT409_10910	COG3119	arylsulfatase activity
GT409_10915	COG2211	Major facilitator Superfamily
GT409_10920	COG5434	Belongs to the glycosyl hydrolase 28 family
GT409_10925	COG0445	tRNA wobble uridine modification
GT409_10930	COG3119	arylsulfatase activity
GT409_10960	COG2197	response regulator
GT409_10970	COG3119	arylsulfatase activity
GT409_10975	COG3119	arylsulfatase activity
GT409_10990	COG1335	isochorismatase
GT409_10995	COG1349	DNA-binding transcription factor activity
GT409_11000	COG0508	dehydrogenase complex catalyzes the overall conversion of
GT409_11005	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
GT409_11010	COG0022	dehydrogenase e1 component
GT409_11025	COG1063	alcohol dehydrogenase
GT409_11030	COG0432	Pfam Uncharacterised protein family UPF0047
GT409_11035	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
GT409_11040	COG1475	DNA binding
GT409_11055	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
GT409_11060	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
GT409_11065	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
GT409_11070	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
GT409_11080	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
GT409_11090	COG3328	transposase activity
GT409_11100	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
GT409_11110	COG0509	glycine decarboxylation via glycine cleavage system
GT409_11115	COG0321	lipoyl(octanoyl) transferase activity
GT409_11120	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
GT409_11130	COG3118	belongs to the thioredoxin family
GT409_11135	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
GT409_11140	COG0799	negative regulation of ribosome biogenesis
GT409_11150	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
GT409_11170	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
GT409_11175	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
GT409_11180	COG4659	FMN binding
GT409_11185	COG1805	sodium ion transport
GT409_11195	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
GT409_11205	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
GT409_11225	COG2731	YhcH YjgK YiaL family protein
GT409_11265	COG2221	Nitrite and sulphite reductase 4Fe-4S
GT409_11285	COG1011	Hydrolase
GT409_11290	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
GT409_11295	COG0297	glycogen (starch) synthase activity
GT409_11300	COG0028	Belongs to the TPP enzyme family
GT409_11305	COG0440	acetolactate synthase activity
GT409_11315	COG0641	radical SAM
GT409_11320	COG1262	PFAM Formylglycine-generating sulfatase enzyme
GT409_11380	COG0662	Cupin 2, conserved barrel domain protein
GT409_11380	COG2207	Transcriptional regulator
GT409_11405	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
GT409_11405	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
GT409_11410	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
GT409_11415	COG0519	Catalyzes the synthesis of GMP from XMP
GT409_11465	COG0811	peptide transport
GT409_11470	COG0811	peptide transport
GT409_11475	COG0848	biopolymer transport protein
GT409_11490	COG0564	pseudouridine synthase activity
GT409_11495	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
GT409_11510	COG1028	Short-chain dehydrogenase reductase Sdr
GT409_11515	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
GT409_11525	COG1073	alpha beta
GT409_11535	COG4968	Prepilin-type N-terminal cleavage methylation domain
GT409_11560	COG0251	oxidation-reduction process
GT409_11565	COG2081	HI0933 family
GT409_11570	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
GT409_11575	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
GT409_11580	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
GT409_11595	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
GT409_11635	COG3119	arylsulfatase activity
GT409_11640	COG1609	Transcriptional regulator
GT409_11645	COG3408	Glycogen debranching enzyme
GT409_11645	COG3119	arylsulfatase activity
GT409_11670	COG3119	arylsulfatase activity
GT409_11685	COG1477	protein flavinylation
GT409_11690	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
GT409_11695	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
GT409_11700	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GT409_11705	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
GT409_11730	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
GT409_11735	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GT409_11750	COG1937	Protein conserved in bacteria
GT409_11755	COG1181	Belongs to the D-alanine--D-alanine ligase family
GT409_11760	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
GT409_11770	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
GT409_11780	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
GT409_11805	COG2304	oxidoreductase activity
GT409_11830	COG0714	Associated with various cellular activities
GT409_11850	COG0484	heat shock protein binding
GT409_11890	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
GT409_11910	COG3119	arylsulfatase activity
GT409_11930	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
GT409_11960	COG3254	rhamnose metabolic process
GT409_12080	COG1609	Transcriptional regulator
GT409_12095	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
GT409_12115	COG3119	arylsulfatase activity
GT409_12145	COG3328	transposase activity
GT409_12165	COG1385	rRNA (uridine-N3-)-methyltransferase activity
GT409_12170	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
GT409_12175	COG1785	Belongs to the alkaline phosphatase family
GT409_12210	COG0175	sulfate reduction
GT409_12215	COG0529	Catalyzes the synthesis of activated sulfate
GT409_12215	COG2895	sulfate adenylyltransferase (ATP) activity
GT409_12220	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
GT409_12230	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
GT409_12240	COG1088	dTDP-glucose 4,6-dehydratase activity
GT409_12250	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
GT409_12265	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
GT409_12270	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
GT409_12300	COG2244	polysaccharide biosynthetic process
GT409_12320	COG1045	serine acetyltransferase
GT409_12350	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
GT409_12385	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
GT409_12405	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
GT409_12410	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
GT409_12425	COG0517	IMP dehydrogenase activity
GT409_12425	COG0617	tRNA 3'-terminal CCA addition
GT409_12425	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
GT409_12440	COG0589	response to stress
GT409_12445	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GT409_12450	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
GT409_12455	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
GT409_12465	COG4589	Belongs to the CDS family
GT409_12485	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
GT409_12495	COG0459	protein refolding
GT409_12500	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
GT409_12505	COG0443	Heat shock 70 kDa protein
GT409_12520	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
GT409_12525	COG0525	valine-tRNA ligase activity
GT409_12530	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
GT409_12535	COG1216	Glycosyl transferase, family 2
GT409_12545	COG0316	Belongs to the HesB IscA family
GT409_12545	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
GT409_12580	COG0018	arginyl-trna synthetase
GT409_12600	COG1773	rubredoxin
GT409_12600	COG0426	domain, Protein
GT409_12605	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
GT409_12615	COG2131	deaminase
GT409_12625	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
GT409_12650	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
GT409_12655	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
GT409_12660	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
GT409_12665	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
GT409_12685	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
GT409_12690	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
GT409_12695	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
GT409_12705	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
GT409_12720	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
GT409_12725	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
GT409_12735	COG0673	inositol 2-dehydrogenase activity
GT409_12740	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
GT409_12760	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
GT409_12780	COG0438	transferase activity, transferring glycosyl groups
GT409_12790	COG0438	transferase activity, transferring glycosyl groups
GT409_12810	COG0438	transferase activity, transferring glycosyl groups
GT409_12860	COG0489	protein tyrosine kinase activity
GT409_12865	COG1596	polysaccharide export
GT409_12875	COG4535	Mg2 and Co2 transporter CorC
GT409_12880	COG4535	Mg2 and Co2 transporter CorC
GT409_12905	COG4807	Protein conserved in bacteria
GT409_12940	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
GT409_12940	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
GT409_12945	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
GT409_12950	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
GT409_12955	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
GT409_12955	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
GT409_12970	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
GT409_12975	COG1132	(ABC) transporter
GT409_12985	COG3119	arylsulfatase activity
GT409_13005	COG3119	arylsulfatase activity
GT409_13015	COG2197	response regulator
GT409_13040	COG3119	arylsulfatase activity
GT409_13045	COG0823	Involved in the tonB-independent uptake of proteins
GT409_13045	COG1506	peptidase
GT409_13050	COG3119	arylsulfatase activity
GT409_13055	COG3119	arylsulfatase activity
GT409_13065	COG3119	arylsulfatase activity
GT409_13070	COG3119	arylsulfatase activity
GT409_13080	COG2197	response regulator
GT409_13100	COG3250	beta-galactosidase activity
GT409_13110	COG3976	FMN-binding domain protein
GT409_13110	COG1053	succinate dehydrogenase
GT409_13130	COG3119	arylsulfatase activity
GT409_13145	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GT409_13210	COG0848	biopolymer transport protein
GT409_13230	COG0756	dUTP diphosphatase activity
GT409_13235	COG1242	4 iron, 4 sulfur cluster binding
GT409_13245	COG0402	S-adenosylhomocysteine deaminase activity
GT409_13250	COG1606	tRNA processing
GT409_13265	COG0497	DNA recombination
GT409_13275	COG3914	O-linked N-acetylglucosamine transferase SPINDLY family
GT409_13280	COG0745	RESPONSE REGULATOR receiver
GT409_13285	COG2205	protein histidine kinase activity
GT409_13335	COG3119	arylsulfatase activity
GT409_13370	COG3119	arylsulfatase activity
GT409_13375	COG4977	sequence-specific DNA binding
GT409_13400	COG3119	arylsulfatase activity
GT409_13410	COG3119	arylsulfatase activity
GT409_13415	COG3119	arylsulfatase activity
GT409_13430	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
GT409_13465	COG1466	dna polymerase III delta subunit
GT409_13470	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
GT409_13485	COG0351	phosphomethylpyrimidine kinase
GT409_13495	COG0148	phosphopyruvate hydratase activity
GT409_13515	COG0406	alpha-ribazole phosphatase activity
GT409_13520	COG1132	(ABC) transporter
GT409_13530	COG2706	6-phosphogluconolactonase activity
GT409_13535	COG0322	excinuclease ABC activity
GT409_13545	COG0540	Belongs to the ATCase OTCase family
GT409_13550	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
GT409_13555	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
GT409_13560	COG0501	Belongs to the peptidase M48B family
GT409_13570	COG1283	sodium-dependent phosphate transmembrane transporter activity
GT409_13580	COG1293	RNA-binding protein homologous to eukaryotic snRNP
GT409_13600	COG0534	Mate efflux family protein
GT409_13610	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
GT409_13615	COG0573	inorganic phosphate transmembrane transporter activity
GT409_13620	COG0581	inorganic phosphate transmembrane transporter activity
GT409_13625	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
GT409_13630	COG0704	Plays a role in the regulation of phosphate uptake
GT409_13640	COG5002	protein histidine kinase activity
GT409_13645	COG1051	belongs to the nudix hydrolase family
GT409_13650	COG0116	Belongs to the methyltransferase superfamily
GT409_13655	COG0101	tRNA pseudouridine synthase activity
GT409_13680	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
GT409_13685	COG0481	GTPase activity
GT409_13690	COG0681	Belongs to the peptidase S26 family
GT409_13695	COG1530	ribonuclease E activity
GT409_13700	COG0772	Belongs to the SEDS family
GT409_13705	COG0768	penicillin binding
GT409_13730	COG1459	type II secretion system
GT409_13740	COG2165	general secretion pathway protein
GT409_13775	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
GT409_13780	COG0778	Nitroreductase
GT409_13795	COG0697	spore germination
GT409_13800	COG0242	peptide deformylase activity
GT409_13990	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
GT409_14000	COG4585	Histidine kinase
GT409_14005	COG2197	response regulator
GT409_14020	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
GT409_14025	COG1459	type II secretion system
GT409_14085	COG0848	biopolymer transport protein
GT409_14110	COG1752	Esterase of the alpha-beta hydrolase superfamily
GT409_14120	COG1509	lysine 2,3-aminomutase activity
GT409_14125	COG0058	SHG alpha-glucan phosphorylase activity
GT409_14135	COG4657	Part of a membrane complex involved in electron transport
GT409_14140	COG1148	4fe-4S ferredoxin, iron-sulfur binding domain protein
GT409_14140	COG2878	Part of a membrane complex involved in electron transport
GT409_14145	COG4656	Part of a membrane complex involved in electron transport
GT409_14150	COG4658	electron transport chain
GT409_14160	COG4660	Part of a membrane complex involved in electron transport
GT409_14165	COG4974	Belongs to the 'phage' integrase family
GT409_14170	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
GT409_14175	COG1104	cysteine desulfurase activity
GT409_14190	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
GT409_14210	COG0326	Molecular chaperone. Has ATPase activity
GT409_14220	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
GT409_14235	COG0438	transferase activity, transferring glycosyl groups
GT409_14250	COG1442	glycosyl transferase family 8
GT409_14255	COG3267	Type II secretory pathway component ExeA
GT409_14255	COG3409	Peptidoglycan-binding domain 1 protein
GT409_14270	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
GT409_14275	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
GT409_14315	COG0617	tRNA 3'-terminal CCA addition
GT409_14320	COG1966	Carbon starvation protein
GT409_14325	COG0302	gtp cyclohydrolase
GT409_14345	COG0613	PHP domain protein
GT409_14350	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
GT409_14400	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
GT409_14425	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
GT409_14440	COG2003	Belongs to the UPF0758 family
GT409_14460	COG0659	secondary active sulfate transmembrane transporter activity
GT409_14480	COG1968	undecaprenyl-diphosphatase activity
GT409_14490	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
GT409_14505	COG0673	inositol 2-dehydrogenase activity
GT409_14510	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
GT409_14515	COG0825	malonyl-CoA metabolic process
GT409_14530	COG0571	ribonuclease III activity
GT409_14535	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
GT409_14540	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
GT409_14545	COG0124	histidyl-tRNA synthetase
GT409_14550	COG0776	regulation of translation
GT409_14560	COG0442	prolyl-tRNA aminoacylation
GT409_14580	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
GT409_14585	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
GT409_14620	COG0673	inositol 2-dehydrogenase activity
GT409_14625	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
GT409_14645	COG1609	Transcriptional regulator
GT409_14655	COG1028	Short-chain dehydrogenase reductase Sdr
GT409_14660	COG1902	pentaerythritol trinitrate reductase activity
GT409_14680	COG1595	DNA-templated transcription, initiation
GT409_14690	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
GT409_14695	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
GT409_14700	COG0287	Prephenate dehydrogenase
GT409_14715	COG0542	response to heat
GT409_14730	COG5012	cobalamin binding
GT409_14735	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
GT409_14735	COG2207	Transcriptional regulator
GT409_14750	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
GT409_14760	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
GT409_14770	COG0482	sulfurtransferase activity
GT409_14795	COG3459	Glycosyltransferase 36 associated
GT409_14810	COG3328	transposase activity
GT409_14820	COG3119	arylsulfatase activity
GT409_14845	COG2963	transposase activity
GT409_14850	COG2207	Transcriptional regulator
GT409_14885	COG3858	chitin binding
GT409_14900	COG3055	Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses
GT409_14945	COG3119	arylsulfatase activity
GT409_14950	COG3119	arylsulfatase activity
GT409_14955	COG3119	arylsulfatase activity
GT409_14960	COG2211	Major facilitator Superfamily
GT409_14965	COG3250	beta-galactosidase activity
GT409_14970	COG1609	Transcriptional regulator
GT409_14975	COG3977	Valine--pyruvate aminotransferase
GT409_14985	COG0166	Belongs to the GPI family
GT409_14995	COG0668	transmembrane transport
GT409_15000	COG1640	4-alpha-glucanotransferase
GT409_15010	COG3512	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
GT409_15025	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
GT409_15030	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
GT409_15045	COG0488	(ABC) transporter
GT409_15055	COG0235	Class ii aldolase
GT409_15065	COG1454	alcohol dehydrogenase
GT409_15070	COG3254	rhamnose metabolic process
GT409_15085	COG3119	arylsulfatase activity
GT409_15100	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
GT409_15110	COG4191	Histidine kinase
GT409_15130	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
GT409_15135	COG3012	SEC-C Motif Domain Protein
GT409_15180	COG3119	arylsulfatase activity
GT409_15185	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
GT409_15190	COG0667	Aldo Keto reductase
GT409_15205	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
GT409_15210	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
GT409_15220	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
GT409_15225	COG1040	competence protein
GT409_15230	COG4796	Type ii and iii secretion system protein
GT409_15250	COG1030	water channel activity
GT409_15260	COG4864	UPF0365 protein
GT409_15285	COG3940	Belongs to the glycosyl hydrolase 43 family
GT409_15305	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
GT409_15310	COG0023	Translation Initiation Factor
GT409_15320	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
GT409_15325	COG0131	Imidazoleglycerol-phosphate dehydratase
GT409_15330	COG0820	rRNA (adenine-C2-)-methyltransferase activity
GT409_15340	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
GT409_15345	COG1030	water channel activity
GT409_15360	COG0848	biopolymer transport protein
GT409_15370	COG0811	peptide transport
GT409_15405	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
GT409_15415	COG0812	UDP-N-acetylmuramate dehydrogenase activity
GT409_15420	COG5434	Belongs to the glycosyl hydrolase 28 family
GT409_15435	COG3408	Glycogen debranching enzyme
GT409_15435	COG3119	arylsulfatase activity
GT409_15440	COG0584	glycerophosphoryl diester phosphodiesterase
GT409_15455	COG2211	Major facilitator Superfamily
GT409_15470	COG3119	arylsulfatase activity
GT409_15475	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
GT409_15480	COG3119	arylsulfatase activity
GT409_15495	COG3119	arylsulfatase activity
GT409_15510	COG4977	sequence-specific DNA binding
GT409_15535	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
GT409_15540	COG2211	Major facilitator Superfamily
GT409_15555	COG3119	arylsulfatase activity
GT409_15565	COG1609	Transcriptional regulator
GT409_15570	COG4771	TonB-dependent receptor
GT409_15575	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
GT409_15585	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GT409_15595	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
GT409_15610	COG0066	3-isopropylmalate dehydratase activity
GT409_15615	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
GT409_15620	COG0052	Belongs to the universal ribosomal protein uS2 family
GT409_15625	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
GT409_15635	COG0788	formyltetrahydrofolate deformylase activity
GT409_15645	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
GT409_15670	COG1199	ATP-dependent helicase activity
GT409_15680	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
GT409_15690	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
GT409_15700	COG0539	negative regulation of cytoplasmic translation
GT409_15700	COG2183	response to ionizing radiation
GT409_15705	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
GT409_15780	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
GT409_15785	COG1459	type II secretion system
GT409_15795	COG2204	response regulator
GT409_15810	COG0792	nuclease activity
GT409_15815	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
GT409_15820	COG0335	large ribosomal subunit rRNA binding
GT409_15825	COG0142	geranyltranstransferase activity