locus-tag class description EQM13_00010 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) EQM13_00020 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) EQM13_00030 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) EQM13_00035 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) EQM13_00040 ENOG4105WN5 stage II sporulation protein EQM13_00075 ENOG4105C52 Atpase, p-type (Transporting), had superfamily, subfamily ic EQM13_00085 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family EQM13_00135 ENOG4105D8X mechanosensitive ion channel EQM13_00140 ENOG4105VDK protein, conserved in bacteria EQM13_00145 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family EQM13_00150 ENOG4108ZDX Binds together with S18 to 16S ribosomal RNA (By similarity) EQM13_00155 ENOG4108UUM single-stranded DNA-binding protein EQM13_00185 ENOG4105CDU Replicative dna helicase EQM13_00205 ENOG4108Z3G 3H domain protein EQM13_00215 ENOG4105E1F short-chain dehydrogenase reductase EQM13_00225 ENOG4108Z6B deaminase EQM13_00235 ENOG4105C19 ABC transporter EQM13_00250 ENOG4105EWM Histidine kinase EQM13_00300 ENOG4105K4W Could be involved in septation (By similarity) EQM13_00310 ENOG4106A3R peptidase EQM13_00405 ENOG4105DR5 peptidase EQM13_00495 ENOG4108YZM Toxic component of a toxin-antitoxin (TA) module (By similarity) EQM13_00600 ENOG410834F Transcriptional regulator EQM13_00640 ENOG4105CE1 Ferrous iron transport protein b EQM13_00660 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase EQM13_00685 ENOG4105CSG Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps (By similarity) EQM13_00690 ENOG41080HT Transcriptional regulator, arsr family EQM13_00700 ENOG4105DT3 PTS system, galactitol-specific IIc component EQM13_00705 ENOG4105K18 The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane (By similarity) EQM13_00710 ENOG4105CPQ Dehydrogenase EQM13_00715 ENOG4107W7X Aldolase EQM13_00725 ENOG4105E1K spore germination protein EQM13_00745 ENOG4105CH6 catalase EQM13_00750 ENOG4105CK6 Two component transcriptional regulator (Winged helix family EQM13_00755 ENOG4105BZU Histidine kinase EQM13_00760 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) EQM13_00775 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) EQM13_00795 ENOG4107S9D Alpha beta hydrolase EQM13_00800 ENOG4105CUP Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB) (By similarity) EQM13_00805 ENOG4108YZT Adenosylcobinamide kinase EQM13_00810 ENOG4107ZET Joins Ado-cobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin) (By similarity) EQM13_00885 ENOG4108JIQ Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit (By similarity) EQM13_00890 ENOG4108JIP Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit (By similarity) EQM13_00895 ENOG4106C6A Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) EQM13_00900 ENOG4105C7R Atpase associated with various cellular activities aaa_3 EQM13_00905 ENOG4105DAP Nicotinate phosphoribosyltransferase EQM13_00925 ENOG4105CE1 Ferrous iron transport protein b EQM13_00950 ENOG4105C59 p-type ATPase EQM13_00965 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit EQM13_01000 ENOG4105I03 Flagellin EQM13_01020 ENOG4105C4X radical SAM domain protein EQM13_01045 ENOG4105BZ1 (ABC) transporter EQM13_01050 ENOG4105C6E dna polymerase iii EQM13_01055 ENOG410816I Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity) EQM13_01095 ENOG4107QMH DNA methylase EQM13_01140 ENOG4105EKQ RNA-directed DNA polymerase EQM13_01250 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) EQM13_01265 ENOG4105MU5 relaxase mobilization nuclease domain protein EQM13_01325 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) EQM13_01375 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) EQM13_01380 ENOG4105C4R Atp-dependent dna helicase EQM13_01420 ENOG4105CDU Replicative dna helicase EQM13_01430 ENOG4105TIV Cryptic phage CTXphi transcriptional repressor RstR EQM13_01495 ENOG41088CC tellurite resistance protein tehB EQM13_01525 ENOG4105D6J arsenicaL-resistance protein EQM13_01575 ENOG4105D9Q decarboxylase (Beta subunit) EQM13_01625 ENOG4108WVK Could be a S-adenosyl-L-methionine-dependent methyltransferase (By similarity) EQM13_01640 ENOG4108IUW ABC transporter EQM13_01660 ENOG4108IMY Transcriptional regulator EQM13_01665 ENOG4105WBV Transcriptional regulator EQM13_01670 ENOG4108J59 Extracellular solute-binding protein, family 5 EQM13_01675 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component EQM13_01680 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component EQM13_01690 ENOG4108JQ7 (ABC) transporter EQM13_01715 ENOG4105CZC PTS system ascorbate-specific transporter subunit IIC EQM13_01730 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) EQM13_01745 ENOG4107RUY (E1 component), alpha subunit EQM13_01750 ENOG4105CPP Dehydrogenase, E1 component EQM13_01755 ENOG4106Z86 ATP-nad acox kinase EQM13_01770 ENOG4105CD5 CoA-binding domain protein EQM13_01775 ENOG4105C0Y Responsible for the amidation of carboxylic groups at position A and C of either cobyrinic acid or hydrogenobrynic acid. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) EQM13_01780 ENOG41068B1 Cob-I-yrinic acid a,c-diamide adenosyltransferase EQM13_01785 ENOG41081F0 Precorrin-8x methylmutase EQM13_01790 ENOG4105EE8 May catalyze the methylation of C-1 in cobalt-precorrin- 5 and the subsequent extrusion of acetic acid from the resulting intermediate to form cobalt-precorrin-6A (By similarity) EQM13_01795 ENOG4105CIA precorrin-4 C(11)-methyltransferase EQM13_01800 ENOG4105CX4 Precorrin-6y C5,15-methyltransferase EQM13_01805 ENOG4105DVK Precorrin-2 c20-methyltransferase EQM13_01810 ENOG4105CIA precorrin-4 C(11)-methyltransferase EQM13_01815 ENOG4108P62 biosynthesis protein (CbiG) EQM13_01820 ENOG4105E4R Precorrin-3B C17-methyltransferase EQM13_01825 ENOG4108JTQ reductase EQM13_01830 ENOG4107PPM cobalt chelatase EQM13_01840 ENOG4108U1V ABC transporter, permease EQM13_01850 ENOG4105DC7 peptidase M24 EQM13_01865 ENOG4105C7J ABC transporter, permease EQM13_01890 ENOG4105DEF Extracellular solute-binding protein, family 5 EQM13_01895 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component EQM13_01910 ENOG4108JQ7 (ABC) transporter EQM13_01915 ENOG4107S4Y M20 DapE family protein YgeY EQM13_01920 ENOG4105CD3 dihydroorotase EQM13_01925 ENOG4105CI2 imidazolone-5-propionate hydrolase EQM13_01935 ENOG4105CTZ aminopeptidase c EQM13_01950 ENOG4105CTX dehydratase EQM13_01970 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) EQM13_01995 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) EQM13_02020 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) EQM13_02030 ENOG4105BZ1 (ABC) transporter EQM13_02060 ENOG4105BZ1 (ABC) transporter EQM13_02100 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) EQM13_02125 ENOG4105CID antiterminator EQM13_02130 ENOG41069H0 dihydroorotase EC 3.5.2.3 EQM13_02195 ENOG4105DA5 (ABC) transporter EQM13_02215 ENOG4105EMD TRANSCRIPTIONal EQM13_02225 ENOG4105CK1 PTS System EQM13_02235 ENOG4105CS2 ec 3.2.1.21 EQM13_02240 ENOG4108RVA ribokinase EQM13_02245 ENOG4105ETE Transcriptional regulator (LacI family EQM13_02275 ENOG4108XBJ The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane (By similarity) EQM13_02290 ENOG4105DT3 PTS system, galactitol-specific IIc component EQM13_02300 ENOG4105DET Rhamnulokinase EQM13_02315 ENOG4108X7Y Mannitol-specific cryptic phosphotransferase enzyme iia EQM13_02330 ENOG4108X7Y Mannitol-specific cryptic phosphotransferase enzyme iia EQM13_02335 ENOG4108JQ1 Dehydrogenase EQM13_02340 ENOG4105DG4 malate L-lactate dehydrogenase EQM13_02355 ENOG4105DBZ Dtdp-4-dehydrorhamnose reductase EQM13_02390 ENOG4107QNG Phosphoribosylglycinamide synthetase EQM13_02400 ENOG4108V3E phosphoribosylglycinamide formyltransferase EQM13_02420 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) EQM13_02425 ENOG4108JIU phosphoribosylformylglycinamidine synthase ii EQM13_02435 ENOG4105BZW Glycerate kinase EQM13_02440 ENOG4108IGT Dipeptidase EQM13_02460 ENOG4105CHR reductase EQM13_02485 ENOG4105F3H Histidine kinase EQM13_02500 ENOG4107QK8 The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor EQM13_02505 ENOG4107RGW The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor EQM13_02510 ENOG4107QN2 dihydrolipoyl dehydrogenase EQM13_02525 ENOG4105KW6 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity) EQM13_02530 ENOG4105NBF ammecr1 domain protein EQM13_02540 ENOG4105CXN decarboxylase EQM13_02545 ENOG4108ZMD Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) EQM13_02550 ENOG4105X0R protein from nitrogen regulatory protein P-II EQM13_02555 ENOG4105X0R protein from nitrogen regulatory protein P-II EQM13_02560 ENOG4107QRG dna polymerase iii EQM13_02565 ENOG4105MA4 psp1 domain protein EQM13_02570 ENOG41084EF Ferredoxin EQM13_02575 ENOG4107S47 Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC) (By similarity) EQM13_02580 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) EQM13_02585 ENOG4105KRN Transcriptional regulator, abrb family EQM13_02600 ENOG4108JIC nucleoside recognition domain protein EQM13_02610 ENOG41069ER domain protein EQM13_02615 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) EQM13_02620 ENOG4105F8V Hydrolase, tatD family EQM13_02625 ENOG4105HVR Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step (By similarity) EQM13_02630 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) EQM13_02640 ENOG4107YCR Transcriptional regulator, ARSR family EQM13_02675 ENOG4105D1F ATP-binding protein EQM13_02680 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A EQM13_02685 ENOG4105CPQ Dehydrogenase EQM13_02690 ENOG4105DKT Transcriptional regulator EQM13_02705 ENOG410787A Pts system, glucitol sorbitol-specific EQM13_02720 ENOG4105JFG SpoIID LytB domain protein EQM13_02725 ENOG4105W42 Veg protein EQM13_02730 ENOG4105S7A ErfK ybiS ycfS ynhG family protein EQM13_02760 ENOG4108ZXQ stage ii sporulation protein r EQM13_02770 ENOG4105MSI germination protein ypeb EQM13_02775 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) EQM13_02780 ENOG4108JUB Transcriptional regulator EQM13_02785 ENOG4105FRY Dehydrogenase EQM13_02805 ENOG4105EQ5 D-Lysine 5,6-aminomutase alpha subunit EQM13_02810 ENOG4107CHF 5,6-aminomutase beta subunit EQM13_02840 ENOG4105CN1 protease EQM13_02845 ENOG4105HIR S-layer domain protein EQM13_02895 ENOG4105ETZ PTS System EQM13_02900 ENOG4105F3R pts system mannose fructose sorbose family iid EQM13_02905 ENOG4105KPI PTS system sorbose subfamily IIB component EQM13_02925 ENOG4105DH2 Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group (By similarity) EQM13_02935 ENOG4107104 thymidine kinase EQM13_02945 ENOG4105CEU Arginine dihydrolase EQM13_02950 ENOG4105DBV ornithine carbamoyltransferase EQM13_02975 ENOG4105C32 Amino acid ABC transporter (Permease) EQM13_02980 ENOG4105CF8 branched-chain amino acid ABC transporter, permease EQM13_02985 ENOG4105C0Z ABC transporter EQM13_02990 ENOG4108IV0 ABC, transporter EQM13_02995 ENOG4105KZ7 phosphocarrier protein hpr EQM13_03000 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family EQM13_03005 ENOG4108XCU pts system EQM13_03010 ENOG4105DAS pts system EQM13_03015 ENOG4105ETZ PTS System EQM13_03020 ENOG4105F3R pts system mannose fructose sorbose family iid EQM13_03035 ENOG4105F55 Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate (By similarity) EQM13_03040 ENOG4105CPQ Dehydrogenase EQM13_03050 ENOG4107QW4 alcohol dehydrogenase EQM13_03060 ENOG4105CJR Integral membrane protein (MviN EQM13_03065 ENOG4105D7W serine acetyltransferase EQM13_03110 ENOG4105CV8 reductase EQM13_03130 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) EQM13_03140 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) EQM13_03145 ENOG4105D82 Glutamate dehydrogenase EQM13_03150 ENOG4108UYI beta-alanyl-CoA ammonia lyase EQM13_03155 ENOG4105DE9 3-keto-5-aminohexanoate cleavage enzyme EQM13_03160 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) EQM13_03165 ENOG4105CBT Fructose-1,6-bisphosphatase EQM13_03170 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) EQM13_03175 ENOG41082DI 50s ribosomal protein l31 EQM13_03180 ENOG4105CBJ Metal-dependent enzyme EQM13_03185 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) EQM13_03200 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) EQM13_03210 ENOG4108YZG isomerase EQM13_03215 ENOG4105CZ5 Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity) EQM13_03220 ENOG4105NBU tryptophan transport protein EQM13_03225 ENOG4105ESV Glycosyl transferase, family 4 EQM13_03230 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase EQM13_03235 ENOG4108JUB Transcriptional regulator EQM13_03240 ENOG4105CHU acetyl-coa acetyltransferase EQM13_03245 ENOG4107QP7 CoA-transferase subunit A EQM13_03255 ENOG410865Q Potassium uptake protein EQM13_03260 ENOG4105CZN Potassium uptake protein EQM13_03270 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) EQM13_03280 ENOG4105DR5 peptidase EQM13_03285 ENOG4105MT0 Sporulation transcriptional regulator spoiiid EQM13_03290 ENOG4105DFF Rod shape-determining protein mreb EQM13_03295 ENOG4105CGA flagellar basal-body rod protein FlgG EQM13_03300 ENOG4105CGA flagellar basal-body rod protein FlgG EQM13_03330 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP EQM13_03340 ENOG4105R6B The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane (By similarity) EQM13_03345 ENOG410863U PTS System EQM13_03350 ENOG4105C8I hydrolase, family 38 EQM13_03360 ENOG4105DG6 mannose-6-phosphate isomerase EQM13_03365 ENOG4105C7H Helicase, RecD TraA family EQM13_03370 ENOG4105C5T Phosphoribosyl pyrophosphate synthase EQM13_03390 ENOG4105E1Q flagellar hook-associated protein EQM13_03400 ENOG4105DTJ flagellar hook-associated protein EQM13_03405 ENOG4105W5T Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum (By similarity) EQM13_03410 ENOG4105VM8 Could accelerate the degradation of some genes transcripts potentially through selective RNA binding (By similarity) EQM13_03430 ENOG41090QV Protein of unknown function DUF115 EQM13_03445 ENOG4105C3U ABC transporter EQM13_03455 ENOG4105I03 Flagellin EQM13_03455 ENOG4105I03 Flagellin EQM13_03465 ENOG4105N2W Transcriptional regulator EQM13_03470 ENOG4105F1A Pyruvate formate-lyase EQM13_03480 ENOG4105VCP PTS System EQM13_03490 ENOG4105CK1 PTS System EQM13_03510 ENOG4105EJZ Glucose-1-phosphate cytidylyltransferase EQM13_03520 ENOG4107SE4 UDP-N-acetylglucosamine 2-epimerase EQM13_03525 ENOG4105D2T synthase EQM13_03545 ENOG4105CMR udp-glucose 4-epimerase EQM13_03560 ENOG4105EMD TRANSCRIPTIONal EQM13_03565 ENOG4105CR5 Class II aldolase adducin family protein EQM13_03570 ENOG4105CPQ Dehydrogenase EQM13_03580 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) EQM13_03585 ENOG41090UW PTS System EQM13_03590 ENOG4105DT3 PTS system, galactitol-specific IIc component EQM13_03595 ENOG4105CHR reductase EQM13_03605 ENOG4105QG4 Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde) (By similarity) EQM13_03610 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase EQM13_03615 ENOG4108JQ1 Dehydrogenase EQM13_03620 ENOG4105CPQ Dehydrogenase EQM13_03625 ENOG4105CPF Cell wall formation (By similarity) EQM13_03630 ENOG4105CS2 ec 3.2.1.21 EQM13_03640 ENOG4105CK1 PTS System EQM13_03650 ENOG4105CYT Selenoprotein B, glycine betaine sarcosine D-proline reductase family EQM13_03655 ENOG4105VCP PTS System EQM13_03660 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family EQM13_03665 ENOG4105CE4 GlcNAc 6-P deacetylase EQM13_03670 ENOG4105C6K Malic enzyme EQM13_03695 ENOG4108RAC Rubrerythrin EQM13_03735 ENOG4107RT6 flagellar hook-associated EQM13_03740 ENOG4105MQ3 flagellar protein FliS EQM13_03755 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving EQM13_03760 ENOG4105CG1 Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity) EQM13_03765 ENOG4105C8Q Methyl-accepting chemotaxis EQM13_03770 ENOG4105BZU Histidine kinase EQM13_03775 ENOG4105CXN decarboxylase EQM13_03780 ENOG4108SAX Membrane EQM13_03785 ENOG4108097 ATP-binding protein EQM13_03790 ENOG41072GX Peptidase M22 Glycoprotease EQM13_03800 ENOG4105C5H ABC transporter EQM13_03815 ENOG4105C1G acyl-Coa dehydrogenase EQM13_03820 ENOG4105BZJ Electron transfer flavoprotein EQM13_03825 ENOG4105C10 Electron transfer flavoprotein EQM13_03835 ENOG4108UQV Membrane EQM13_03840 ENOG4105K5Y Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity) EQM13_03845 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) EQM13_03850 ENOG4107RHR regulatoR EQM13_03860 ENOG4105EMN RNA polymerase sigma factor EQM13_03895 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) EQM13_03900 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) EQM13_03915 ENOG4108HED Type II restriction EQM13_03920 ENOG4105D3A purine nucleoside phosphorylase DeoD-type EQM13_03925 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) EQM13_03940 ENOG4105ETZ PTS System EQM13_03945 ENOG4105F3R pts system mannose fructose sorbose family iid EQM13_03950 ENOG4108JQ1 Dehydrogenase EQM13_03960 ENOG4105CI8 Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons (By similarity) EQM13_03975 ENOG4105YHU PTS system EQM13_03980 ENOG4105C2X Arabinose 5-phosphate isomerase EQM13_03985 ENOG4108JQ1 Dehydrogenase EQM13_03995 ENOG4105C5I Dehydrogenase EQM13_04000 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) EQM13_04005 ENOG4105QEK Transcriptional regulator EQM13_04010 ENOG4107R7I amino acid EQM13_04015 ENOG4105DCF alanine dehydrogenase EQM13_04020 ENOG4105EMD TRANSCRIPTIONal EQM13_04030 ENOG4105D2N Aldolase EQM13_04045 ENOG4105K18 The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane (By similarity) EQM13_04050 ENOG4105DT3 PTS system, galactitol-specific IIc component EQM13_04065 ENOG4108JUB Transcriptional regulator EQM13_04075 ENOG4105C35 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity) EQM13_04080 ENOG4105E8R UPF0173 metal-dependent hydrolase EQM13_04085 ENOG4105KGF protein, YerC YecD EQM13_04090 ENOG4105C84 Histidine ammonia-lyase EQM13_04095 ENOG4105CCS Glutamate formiminotransferase EQM13_04110 ENOG4105CI2 imidazolone-5-propionate hydrolase EQM13_04120 ENOG4105C4R Atp-dependent dna helicase EQM13_04125 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) EQM13_04150 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component EQM13_04155 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component EQM13_04165 ENOG4108JQ7 (ABC) transporter EQM13_04170 ENOG4108J59 Extracellular solute-binding protein, family 5 EQM13_04175 ENOG4107QSI ABC, transporter EQM13_04185 ENOG4105CXB phosphoribosylaminoimidazole synthetase EQM13_04190 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase EQM13_04195 ENOG4108U5N UPF0316 protein EQM13_04205 ENOG4105ED0 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity) EQM13_04210 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) EQM13_04245 ENOG4105CBF Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity) EQM13_04260 ENOG4105CBF Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity) EQM13_04270 ENOG4105K56 Transcriptional regulator EQM13_04305 ENOG41067QW Transcriptional regulator EQM13_04315 ENOG4108JUB Transcriptional regulator EQM13_04325 ENOG4108903 Formimidoylglutamase EQM13_04330 ENOG4105CE1 Ferrous iron transport protein b EQM13_04340 ENOG4105KST dependent repressor EQM13_04345 ENOG4105KST dependent repressor EQM13_04360 ENOG4105CJ1 ABC, transporter EQM13_04365 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family EQM13_04370 ENOG4105CZV ABC transporter EQM13_04380 ENOG4105C2Y STE24 endopeptidase EC 3.4.24.84 EQM13_04385 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) EQM13_04395 ENOG4105CJ1 ABC, transporter EQM13_04415 ENOG4105UQX Mate efflux family protein EQM13_04425 ENOG4105UQX Mate efflux family protein EQM13_04450 ENOG4105QD4 Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) EQM13_04465 ENOG4108JIQ Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit (By similarity) EQM13_04470 ENOG4108JIP Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit (By similarity) EQM13_04475 ENOG4105M56 Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) EQM13_04480 ENOG4105CB1 The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate (By similarity) EQM13_04485 ENOG4105C5F glutamine synthetase EQM13_04505 ENOG4105DR1 Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) EQM13_04515 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) EQM13_04525 ENOG4108YZM Toxic component of a toxin-antitoxin (TA) module (By similarity) EQM13_04545 ENOG4105BZF Glycosyl transferase (Group 1 EQM13_04575 ENOG4108JYZ YitT family EQM13_04580 ENOG4108HHA Transketolase EQM13_04600 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase EQM13_04605 ENOG4105CAK Cell division ATP-binding protein ftsE EQM13_04610 ENOG4105CRP Part of the ABC transporter FtsEX involved in EQM13_04615 ENOG41063SB peptidase EQM13_04635 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) EQM13_04640 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) EQM13_04660 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) EQM13_04670 ENOG4105D1C Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion (By similarity) EQM13_04690 ENOG4105D4A Cell wall formation (By similarity) EQM13_04700 ENOG4105C21 Displays ATPase and GTPase activities (By similarity) EQM13_04705 ENOG4105CHW UPF0052 protein EQM13_04715 ENOG41062IR nudix hydrolase EQM13_04720 ENOG4105CIE May be required for sporulation (By similarity) EQM13_04725 ENOG4105KRI phosphocarrier protein (HPr EQM13_04730 ENOG4105C0B DNA polymerase III (alpha subunit) EQM13_04740 ENOG4105CTQ phosphohexokinase EQM13_04750 ENOG4105FS0 cytoplasmic membrane protein EQM13_04755 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) EQM13_04825 ENOG4107QJE Chromosome Partitioning Protein EQM13_04830 ENOG4105FA0 parb-like partition protein EQM13_04880 ENOG4105K4H Nlp p60 protein EQM13_04895 ENOG4105C9U ATP-dependent DNA helicase RecQ EQM13_04950 ENOG4105MU5 relaxase mobilization nuclease domain protein EQM13_04990 ENOG4105VYW UPF0251 protein EQM13_04995 ENOG4107YH3 SUF system FeS assembly protein, NifU family EQM13_05010 ENOG4105WGB oxidoreductase, delta subunit EQM13_05065 ENOG4105C8Q Methyl-accepting chemotaxis EQM13_05085 ENOG4108YZM Toxic component of a toxin-antitoxin (TA) module (By similarity) EQM13_05090 ENOG4108C33 Resolvase EQM13_05095 ENOG41067QW Transcriptional regulator EQM13_05100 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase EQM13_05105 ENOG4105D9U N-acetyltransferase EQM13_05110 ENOG4108JUB Transcriptional regulator EQM13_05115 ENOG4107QK8 The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor EQM13_05120 ENOG4107RGW The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor EQM13_05130 ENOG4105H9W Short-chain dehydrogenase reductase Sdr EQM13_05135 ENOG4108JQ1 Dehydrogenase EQM13_05140 ENOG4105CHM Aminotransferase EQM13_05150 ENOG4105EFZ amidohydrolase EQM13_05155 ENOG4105EXC Acyl-transferase EQM13_05160 ENOG41087PP glycosyltransferase MGT family EQM13_05165 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) EQM13_05175 ENOG4105JKQ Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity) EQM13_05180 ENOG4105S6R Iron-hydroxamate transporter permease subunit EQM13_05190 ENOG4105CTK cobaltochelatase, cobn subunit EQM13_05220 ENOG4108U5J '-nucleotidase EQM13_05240 ENOG4108V4B ThiJ pfpI EQM13_05260 ENOG4105BZ1 (ABC) transporter EQM13_05275 ENOG41067SE Tetr family transcriptional regulator EQM13_05285 ENOG4105BZ1 (ABC) transporter EQM13_05290 ENOG41063VX Inherit from COG: glutaredoxin-related protein EQM13_05320 ENOG4105DA5 (ABC) transporter EQM13_05340 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) EQM13_05350 ENOG41082GB PTS system galactitol-specific transporter subunit IIA EQM13_05365 ENOG4105DT3 PTS system, galactitol-specific IIc component EQM13_05375 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family EQM13_05380 ENOG4107T5V SNARE associated Golgi EQM13_05390 ENOG4105CPC Aldo Keto reductase EQM13_05400 ENOG4105EPR degv family EQM13_05410 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) EQM13_05415 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) EQM13_05420 ENOG4105EWC Purine nucleoside phosphorylase EQM13_05430 ENOG4105DWF phosphomethylpyrimidine kinase EQM13_05435 ENOG4105C5H ABC transporter EQM13_05450 ENOG4105C7N Xanthine uracil vitamin C permease EQM13_05465 ENOG4105D95 Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin (By similarity) EQM13_05470 ENOG4105DDK oxidoreductase, beta subunit EQM13_05485 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase EQM13_05490 ENOG4105E39 Enoyl-CoA hydratase EQM13_05500 ENOG4105C1G acyl-Coa dehydrogenase EQM13_05505 ENOG4105BZJ Electron transfer flavoprotein EQM13_05510 ENOG4105C10 Electron transfer flavoprotein EQM13_05535 ENOG4105CHR reductase EQM13_05540 ENOG4107HP6 Transcriptional regulator EQM13_05545 ENOG4107SDT Homocitrate synthase EQM13_05550 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) EQM13_05555 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) EQM13_05560 ENOG4108JIJ Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second (By similarity) EQM13_05575 ENOG4106ETB IIa component EQM13_05590 ENOG41080QX K07048 phosphotriesterase-related protein EQM13_05600 ENOG4107HP6 Transcriptional regulator EQM13_05620 ENOG4105DIV Catalyzes the conversion of acetaldehyde to acetyl-CoA, using NAD( ) and coenzyme A. Is the final enzyme in the meta- cleavage pathway for the degradation of aromatic compounds (By similarity) EQM13_05625 ENOG4105DF3 Catalyzes the retro-aldol cleavage of 4-hydroxy-2- oxopentanoate to pyruvate and acetaldehyde. Is involved in the meta-cleavage pathway for the degradation of aromatic compounds (By similarity) EQM13_05640 ENOG4105DKK Benzoate EQM13_05675 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin EQM13_05680 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase EQM13_05690 ENOG4105C0D helicase EQM13_05705 ENOG41081HM 2'-5' rna ligase EQM13_05715 ENOG4108K9K Uncharacterised protein family (UPF0236) EQM13_05760 ENOG4105BZ1 (ABC) transporter EQM13_05765 ENOG4105BZ1 (ABC) transporter EQM13_05770 ENOG4107QW8 radical SAM domain protein EQM13_05780 ENOG4105BZ8 glutamate synthase EQM13_05785 ENOG4107SJI Dehydrogenase EQM13_05805 ENOG4108KN7 Removes 5-oxoproline from various penultimate amino acid residues except L-proline (By similarity) EQM13_05825 ENOG4105DZ1 carboxypeptidase EQM13_05885 ENOG4105DVA methyltransferase EQM13_05905 ENOG4105QNR S1 RNA binding domain protein EQM13_06015 ENOG4105DRY peptidase s9 prolyl oligopeptidase active site domain protein EQM13_06020 ENOG4108RTU Aldolase EQM13_06050 ENOG4105BZ1 (ABC) transporter EQM13_06055 ENOG4105BZ1 (ABC) transporter EQM13_06060 ENOG4108QD1 Membrane EQM13_06075 ENOG4105C37 (CBS) domain EQM13_06095 ENOG4107TVC Glycosyl transferase, family 2 EQM13_06100 ENOG4107SIG periplasmic solute binding protein EQM13_06105 ENOG4105DIK (ABC) transporter EQM13_06110 ENOG4107RPQ ABC transporter EQM13_06115 ENOG4105CC5 ABC transporter EQM13_06160 ENOG4105CIN aminoacyl-histidine dipeptidase EQM13_06170 ENOG4105DFM M18 family aminopeptidase EQM13_06175 ENOG410667J hydrolase EQM13_06180 ENOG4105N5T Radical SAM Protein EQM13_06215 ENOG41080XQ Signal transduction protein with cbs domains EQM13_06220 ENOG4105C8Q Methyl-accepting chemotaxis EQM13_06250 ENOG4105CSV Glutaminase EQM13_06260 ENOG4105DIB Oligopeptide-binding protein EQM13_06265 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component EQM13_06270 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component EQM13_06275 ENOG4105C3U ABC transporter EQM13_06280 ENOG4108JQ7 (ABC) transporter EQM13_06290 ENOG4108UI1 Probably functions as a manganese efflux pump (By similarity) EQM13_06295 ENOG4105D17 glycoside hydrolase, family 3 domain protein EQM13_06305 ENOG4107R2I The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation EQM13_06325 ENOG4105CMS peptidase U62, modulator of DNA gyrase EQM13_06330 ENOG4105BZ1 (ABC) transporter EQM13_06340 ENOG4105C3K feS assembly ATPase SufC EQM13_06345 ENOG4105DIW FeS assembly protein SUFB EQM13_06350 ENOG4105JRK feS assembly protein SufD EQM13_06360 ENOG4108UNV SUF system FeS assembly protein, NifU family EQM13_06370 ENOG4105CPF Cell wall formation (By similarity) EQM13_06375 ENOG4107RBI VanW family EQM13_06385 ENOG4105BZ1 (ABC) transporter EQM13_06415 ENOG4105BZ1 (ABC) transporter EQM13_06445 ENOG4108Z7T Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) EQM13_06455 ENOG4108XRC Protein of unknown function (DUF458) EQM13_06470 ENOG4105C5Y PTS System EQM13_06475 ENOG4107RFY SbcCD D subunit EQM13_06500 ENOG4108Z29 Flavodoxin EQM13_06515 ENOG4105C8Q Methyl-accepting chemotaxis EQM13_06540 ENOG4105D01 (LipO)protein EQM13_06545 ENOG4108UMI ABC transporter, permease EQM13_06565 ENOG4105MN5 HAD-superfamily hydrolase subfamily IA variant 3 EQM13_06590 ENOG4105SKN orotidine 5''-phosphate decarboxylase EQM13_06595 ENOG4105DF0 Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD( ) (By similarity) EQM13_06600 ENOG4107W93 Dihydroorotate dehydrogenase EQM13_06610 ENOG4105C8J )-transporter EQM13_06615 ENOG4105E1K spore germination protein EQM13_06630 ENOG4105VEQ Cold shock protein EQM13_06640 ENOG4105C31 Tryptophanyl-tRNA synthetase EQM13_06645 ENOG4108RTU Aldolase EQM13_06660 ENOG4105QEK Transcriptional regulator EQM13_06665 ENOG4105C5I Dehydrogenase EQM13_06670 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) EQM13_06680 ENOG4105F3R pts system mannose fructose sorbose family iid EQM13_06685 ENOG4105DAS pts system EQM13_06690 ENOG4105KPI PTS system sorbose subfamily IIB component EQM13_06695 ENOG4105D2X ABC transporter substrate-binding protein EQM13_06700 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase EQM13_06705 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family EQM13_06710 ENOG4105K18 The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane (By similarity) EQM13_06715 ENOG4105DT3 PTS system, galactitol-specific IIc component EQM13_06720 ENOG4105CPQ Dehydrogenase EQM13_06725 ENOG4105FB2 class II Aldolase EQM13_06730 ENOG4107S8T NAD-dependent 4-hydroxybutyrate dehydrogenase EQM13_06735 ENOG4105CPQ Dehydrogenase EQM13_06745 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) EQM13_06790 ENOG4108UGV hypoxanthine phosphoribosyltransferase EQM13_06795 ENOG4105DMJ Catalyzes the transfer of an acetyl group from acetyl- CoA to tetrahydrodipicolinate (By similarity) EQM13_06800 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) EQM13_06805 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) EQM13_06810 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) EQM13_06825 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) EQM13_06830 ENOG4108D32 Methyltransferase EQM13_06840 ENOG4105F4C Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress (By similarity) EQM13_06870 ENOG4105DPZ Two component transcriptional regulator (Winged helix family EQM13_06895 ENOG4108QBV Monogalactosyldiacylglycerol synthase EQM13_06900 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) EQM13_06915 ENOG4105CUT histidyl-tRNA synthetase EQM13_06920 ENOG4105BZ1 (ABC) transporter EQM13_06925 ENOG4105C22 threonyL-tRNA synthetase EQM13_06935 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) EQM13_06940 ENOG4105VJV 50s ribosomal protein L35 EQM13_06955 ENOG4105CSS phenylalanyl-tRNA synthetase (alpha subunit) EQM13_06960 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) EQM13_06970 ENOG4105CFP Peptidase U32 EQM13_06975 ENOG4105C98 muts2 protein EQM13_06980 ENOG4105C75 arginyL-tRNA synthetase EQM13_06990 ENOG4105EPH radical SAM domain protein EQM13_07005 ENOG4107RE7 phosphate butyryltransferase EQM13_07105 ENOG4105PW4 Sugar fermentation stimulation protein homolog EQM13_07110 ENOG4105C8Q Methyl-accepting chemotaxis EQM13_07115 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein EQM13_07125 ENOG4105DY9 regulatoR EQM13_07145 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) EQM13_07160 ENOG4105BZ1 (ABC) transporter EQM13_07175 ENOG4108UVJ appr-1-p processing domain protein EQM13_07190 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 EQM13_07230 ENOG4105NHU Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group (By similarity) EQM13_07235 ENOG4105KA4 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity) EQM13_07240 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) EQM13_07245 ENOG41061AI Protein of unknown function (DUF2905) EQM13_07250 ENOG4105JFG SpoIID LytB domain protein EQM13_07255 ENOG4105E2N Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity) EQM13_07265 ENOG4105VIE preprotein translocase, subunit YajC EQM13_07290 ENOG4105DY9 regulatoR EQM13_07310 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) EQM13_07375 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) EQM13_07380 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) EQM13_07385 ENOG4108YYA Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity) EQM13_07390 ENOG4105C5X domain protein EQM13_07395 ENOG4105D4P Coproporphyrinogen iii oxidase EQM13_07400 ENOG4105VRR gCN5-related N-acetyltransferase EQM13_07410 ENOG4105ETD TRANSCRIPTIONal EQM13_07425 ENOG4105CK1 PTS System EQM13_07430 ENOG4107QSE Dipeptidase EQM13_07440 ENOG4105VCP PTS System EQM13_07445 ENOG4105C1G acyl-Coa dehydrogenase EQM13_07465 ENOG4105DA5 (ABC) transporter EQM13_07510 ENOG4105KNA -acetyltransferase EQM13_07575 ENOG4105BZ1 (ABC) transporter EQM13_07580 ENOG4105DB9 Binding-protein-dependent transport systems inner membrane component EQM13_07585 ENOG4105C50 Binding-protein-dependent transport systems, inner membrane component EQM13_07600 ENOG4106N3A copper homeostasis protein cutc EQM13_07620 ENOG4105EC3 peptidase S51, dipeptidase E EQM13_07695 ENOG4107TB6 phosphoglycerate mutase EQM13_07735 ENOG4105IBP Cyclic peptide transporter EQM13_07780 ENOG4105CHM Aminotransferase EQM13_07795 ENOG4108YXI Secondary thiamine-phosphate synthase enzyme EQM13_07840 ENOG4105DA6 Catalyzes the conversion of 5-methoxyuridine (mo5U) to uridine-5-oxyacetic acid (cmo5U) at position 34 in tRNA. May also participate in the methylation of uridine-5-oxyacetic acid (cmo5U) to uridine-5-oxyacetic acid methyl ester (mcmo5U) (By similarity) EQM13_07845 ENOG4105DKT Transcriptional regulator EQM13_07850 ENOG4105K18 The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane (By similarity) EQM13_07855 ENOG4107QM2 Aldo Keto reductase EQM13_07860 ENOG4105DT3 PTS system, galactitol-specific IIc component EQM13_07875 ENOG4105DTZ bifunctional PTS system fructose-specific transporter subunit IIA HPr protein EQM13_07880 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) EQM13_07890 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family EQM13_07900 ENOG41090UW PTS System EQM13_07905 ENOG4105DT3 PTS system, galactitol-specific IIc component EQM13_07910 ENOG4108JQ1 Dehydrogenase EQM13_07915 ENOG4105CXK mandelate racemase muconate lactonizing EQM13_07920 ENOG4105DCU 2-hydroxyglutaryl-CoA dehydratase EQM13_07940 ENOG4105C9M aspartyl-trna synthetase EQM13_07960 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) EQM13_07965 ENOG4105S2F EQM13_07980 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) EQM13_07985 ENOG4105K7Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) EQM13_08005 ENOG4105DDT Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity) EQM13_08010 ENOG4105CJ1 ABC, transporter EQM13_08015 ENOG4108US0 Transcription regulator that can specifically activate or repress expression of target genes (By similarity) EQM13_08040 ENOG4105VXP Protein of unknown function DUF86 EQM13_08055 ENOG4105DFA alanine racemase domain protein EQM13_08060 ENOG4105VR5 Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA (By similarity) EQM13_08070 ENOG4105DBK s4 domain protein EQM13_08075 ENOG4105MMF Cell division protein DIVIVA EQM13_08090 ENOG4105M02 This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) EQM13_08095 ENOG4105C34 Pseudouridine synthase EQM13_08100 ENOG4108UK1 Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant (By similarity) EQM13_08110 ENOG4105DSJ YicC domain protein EQM13_08115 ENOG4105KC4 UPF0296 protein EQM13_08120 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) EQM13_08130 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase EQM13_08135 ENOG4105C25 Primosomal protein n' EQM13_08140 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) EQM13_08145 ENOG4105CAE Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) EQM13_08155 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B EQM13_08170 ENOG4105D9P serine threonine protein kinase EQM13_08175 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) EQM13_08180 ENOG4105DJV ribulose-phosphate 3-epimerase EQM13_08200 ENOG4105VB9 50S ribosomal protein l28 EQM13_08205 ENOG4108ZAA Alkaline-shock protein EQM13_08210 ENOG4105DP4 dak2 domain fusion protein ylov EQM13_08215 ENOG4105CB5 ATP-dependent DNA helicase recG EQM13_08220 ENOG4106H78 methyltransferase EQM13_08235 ENOG4105H20 Sporulation integral membrane protein YlbJ EQM13_08240 ENOG4105D78 K07001 NTE family protein EQM13_08250 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) EQM13_08265 ENOG4105C6B Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA (By similarity) EQM13_08270 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) EQM13_08290 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) EQM13_08310 ENOG4105K5M 30s ribosomal protein S16 EQM13_08315 ENOG4105VB6 UPF0109 protein EQM13_08320 ENOG4107Z8R An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity) EQM13_08330 ENOG4105BZ1 (ABC) transporter EQM13_08340 ENOG4105C9W Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity) EQM13_08345 ENOG4108UH2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) EQM13_08355 ENOG4105VM1 flagellar EQM13_08365 ENOG4105C0P Mg chelatase subunit ChlI EQM13_08370 ENOG4105C79 DNA protecting protein DprA EQM13_08375 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) EQM13_08390 ENOG4105EUM DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor (By similarity) EQM13_08395 ENOG4105Q75 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) EQM13_08400 ENOG4108ZC9 flagellar basal-body rod protein flgc EQM13_08405 ENOG4105VQ0 flagellar hook-basal body complex protein fliE EQM13_08410 ENOG4105C1F The M ring may be actively involved in energy transduction (By similarity) EQM13_08415 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) EQM13_08445 ENOG410822I Flagellar hook capping protein EQM13_08455 ENOG4105BZE flagellar hook protein, FlgE EQM13_08465 ENOG4105E14 MotA TolQ exbB proton channel EQM13_08470 ENOG4106VK6 Flagellar motor protein EQM13_08480 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) EQM13_08485 ENOG4105DD5 Flagellar motor switch protein EQM13_08490 ENOG4107YTP response regulator receiver protein EQM13_08500 ENOG4105CN7 Flagellar biosynthetic protein FliP EQM13_08505 ENOG4105VS8 Flagellar biosynthetic protein fliq EQM13_08510 ENOG4105D19 Role in flagellar biosynthesis (By similarity) EQM13_08515 ENOG4105D00 flagellar biosynthetic protein flhB EQM13_08520 ENOG4105D7B Flagellar biosynthesis protein flha EQM13_08525 ENOG4105FZW flagellar biosynthesis regulator FlhF EQM13_08540 ENOG4105CMP catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity) EQM13_08545 ENOG4105CBS Chea signal transduction histidine kinase EQM13_08550 ENOG4108V3W Chemotaxis protein, CheW EQM13_08560 ENOG4108Z4W Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis (By similarity) EQM13_08565 ENOG4105DN4 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) EQM13_08590 ENOG4105C1G acyl-Coa dehydrogenase EQM13_08600 ENOG4105CPF Cell wall formation (By similarity) EQM13_08605 ENOG4105CE9 30S ribosomal protein S2 EQM13_08610 ENOG4105CU7 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity) EQM13_08620 ENOG4108VCV Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity) EQM13_08630 ENOG4105KNE Phosphatidate cytidylyltransferase EQM13_08635 ENOG4105DZP Membrane-associated zinc metalloprotease EQM13_08645 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) EQM13_08650 ENOG4105K7D Required for maturation of 30S ribosomal subunits (By similarity) EQM13_08655 ENOG4105CHV Transcription elongation factor NusA EQM13_08665 ENOG4107EEM One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) EQM13_08670 ENOG4105KG7 Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity) EQM13_08675 ENOG4105SFS phosphoesterase RecJ domain protein EQM13_08680 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) EQM13_08685 ENOG4105DTN riboflavin biosynthesis protein ribF EQM13_08690 ENOG4105K77 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity) EQM13_08695 ENOG4105C62 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) EQM13_08705 ENOG4105C1V Peptidase, M16 EQM13_08710 ENOG4108Z1K This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) EQM13_08725 ENOG4105CVQ ATP-dependent Clp protease, proteolytic subunit EQM13_08730 ENOG4105CNU cell division protein FtsK EQM13_08735 ENOG4105CBM Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 (By similarity) EQM13_08740 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase EQM13_08750 ENOG4105C68 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity) EQM13_08760 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) EQM13_08775 ENOG4105E4Y Endoribonuclease that initiates mRNA decay (By similarity) EQM13_08780 ENOG4105MCT stage V sporulation protein S EQM13_08785 ENOG4105DB7 PHP domain protein EQM13_08795 ENOG4105CHM Aminotransferase EQM13_08805 ENOG4105CJ1 ABC, transporter EQM13_08830 ENOG4108IUW ABC transporter EQM13_08865 ENOG4105CDA abc transporter atp-binding protein EQM13_08870 ENOG4105E5Q amino acid AbC transporter EQM13_08880 ENOG4105E0X reductase EQM13_08885 ENOG4107HP6 Transcriptional regulator EQM13_08890 ENOG4107YB6 acetyltransferase, (GNAT) family EQM13_08905 ENOG4108IYT Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) EQM13_08910 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) EQM13_08915 ENOG4105DJV ribulose-phosphate 3-epimerase EQM13_08925 ENOG4105E98 transcriptional regulator DeoR family EQM13_08930 ENOG4105CXI aluminum resistance protein EQM13_08935 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) EQM13_08945 ENOG4105DC6 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity) EQM13_08950 ENOG4105D86 that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity) EQM13_08955 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) EQM13_08990 ENOG4105BZU Histidine kinase EQM13_08995 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) EQM13_09000 ENOG4105F6E Acyl-transferase EQM13_09010 ENOG4105KHN chorismate mutase EQM13_09020 ENOG4105CBX hi0933 family EQM13_09025 ENOG4105CVJ phosphoglycerate mutase EQM13_09030 ENOG4108PSC Represses the expression of the murPQ operon involved in the uptake and degradation of N-acetylmuramic acid (MurNAc). Binds to two adjacent inverted repeats within the operator region. MurNAc 6-phosphate, the substrate of MurQ, is the specific inducer that weakens binding of MurR to the operator (By similarity) EQM13_09040 ENOG4105DQU oxidoreductase, subunit beta EQM13_09045 ENOG4105DI2 Pyruvate flavodoxin ferredoxin oxidoreductase domain protein EQM13_09055 ENOG4107QSA Oxaloacetate decarboxylase EQM13_09070 ENOG4105FE9 pseudouridine synthase EQM13_09080 ENOG4105DF0 Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD( ) (By similarity) EQM13_09085 ENOG4105DZ1 carboxypeptidase EQM13_09090 ENOG4105KBJ sporulation protein ytfj EQM13_09100 ENOG4105K8I Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity) EQM13_09105 ENOG4108KVX Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves (By similarity) EQM13_09110 ENOG4108Z4T Peptidase M50 EQM13_09115 ENOG4105DZ1 carboxypeptidase EQM13_09130 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) EQM13_09155 ENOG4105CKK Glycosyl transferase, family 2 EQM13_09170 ENOG4107QQR Sporulation EQM13_09200 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component EQM13_09205 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component EQM13_09210 ENOG4108J59 Extracellular solute-binding protein, family 5 EQM13_09215 ENOG4105S1Z Stage IV sporulation protein B EQM13_09220 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) EQM13_09225 ENOG4105XBY Regulates arginine biosynthesis genes (By similarity) EQM13_09230 ENOG4105DX0 Hemolysin A EQM13_09250 ENOG41067QG Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) EQM13_09280 ENOG4108ZSR alkaline shock protein EQM13_09305 ENOG4105KQ4 Stage iii sporulation protein ad EQM13_09320 ENOG4105CD2 stage iii sporulation protein aa EQM13_09330 ENOG4105DRH Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) EQM13_09380 ENOG4106A3R peptidase EQM13_09395 ENOG4105CZX twitching motility protein EQM13_09400 ENOG4107QHF type ii secretion system protein e EQM13_09405 ENOG4108K9K Uncharacterised protein family (UPF0236) EQM13_09415 ENOG41068JE domain protein EQM13_09420 ENOG4107XBN GntR Family Transcriptional Regulator EQM13_09425 ENOG4105CBX hi0933 family EQM13_09430 ENOG4105WCA Ferredoxin EQM13_09460 ENOG4105BZU Histidine kinase EQM13_09480 ENOG4105C87 Aminotransferase class I and II EQM13_09490 ENOG4106V2I dimethylaminohydrolase EQM13_09495 ENOG4108JUB Transcriptional regulator EQM13_09510 ENOG4105BZ1 (ABC) transporter EQM13_09520 ENOG4105DTQ mandelate racemase muconate lactonizing EQM13_09550 ENOG4105K95 (LipO)protein EQM13_09555 ENOG4108YM7 Gcn5-related n-acetyltransferase EQM13_09580 ENOG4107QTR Required for nitrogen fixation. May be part of a membrane complex functioning as an intermediate in the electron transport to nitrogenase (By similarity) EQM13_09585 ENOG4105D6A Electron transport complex EQM13_09590 ENOG41080WF Electron transport complex, RnfABCDGE type, G subunit EQM13_09595 ENOG4105DZB Electron transport complex EQM13_09600 ENOG4105DGN Electron transport complex EQM13_09605 ENOG4107SVV electron transport complex, RnfABCDGE type, B subunit EQM13_09625 ENOG4105DZW Dipeptidase EQM13_09630 ENOG4105D2N Aldolase EQM13_09640 ENOG4105CPQ Dehydrogenase EQM13_09655 ENOG4105DT3 PTS system, galactitol-specific IIc component EQM13_09665 ENOG4105CPQ Dehydrogenase EQM13_09675 ENOG4105CGR Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) EQM13_09720 ENOG4105CB5 ATP-dependent DNA helicase recG EQM13_09730 ENOG4105C7J ABC transporter, permease EQM13_09745 ENOG4108HMR Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) EQM13_09770 ENOG4105C5R Aminotransferase EQM13_09780 ENOG4105ZHF CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease (By similarity) EQM13_09785 ENOG4105DYN CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. May be involved in the integration of spacer DNA into the CRISPR cassette (By similarity) EQM13_09835 ENOG4108BN2 CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease (By similarity) EQM13_09840 ENOG4105DYN CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. May be involved in the integration of spacer DNA into the CRISPR cassette (By similarity) EQM13_09880 ENOG4105H9W Short-chain dehydrogenase reductase Sdr EQM13_09885 ENOG4107S8T NAD-dependent 4-hydroxybutyrate dehydrogenase EQM13_09900 ENOG4105KPI PTS system sorbose subfamily IIB component EQM13_09905 ENOG4105C5I Dehydrogenase EQM13_09910 ENOG4105ETZ PTS System EQM13_09920 ENOG4105D2N Aldolase EQM13_09925 ENOG4105CPQ Dehydrogenase EQM13_09930 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family EQM13_09945 ENOG4105DA5 (ABC) transporter EQM13_09970 ENOG4105DYB Isoaspartyl dipeptidase EQM13_09975 ENOG4105CSX c4-dicarboxylate anaerobic carrier EQM13_10010 ENOG4105CJ1 ABC, transporter EQM13_10015 ENOG4108ZGX Histidine kinase EQM13_10020 ENOG4105WH1 Two component transcriptional regulator luxr family EQM13_10030 ENOG4105RHY Pfam:UPF0157 EQM13_10045 ENOG4105VEQ Cold shock protein EQM13_10060 ENOG4105CTS PTS system mannitol-specific EQM13_10065 ENOG4105DJV ribulose-phosphate 3-epimerase EQM13_10070 ENOG4106P19 photosystem i assembly btpa EQM13_10075 ENOG4105DT3 PTS system, galactitol-specific IIc component EQM13_10080 ENOG41090UW PTS System EQM13_10085 ENOG4105CN9 Peptidase m42 family protein EQM13_10100 ENOG4108IV0 ABC, transporter EQM13_10105 ENOG4105C0Z ABC transporter EQM13_10115 ENOG4105C32 Amino acid ABC transporter (Permease) EQM13_10155 ENOG4107QRT dEAD DEAH box helicase EQM13_10190 ENOG4105MZG transcriptional modulator of maze toxin, mazf EQM13_10200 ENOG4105DZR Type I site-specific deoxyribonuclease EQM13_10220 ENOG4105CVR type I restriction-modification system EQM13_10230 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) EQM13_10270 ENOG4105CJR Integral membrane protein (MviN EQM13_10310 ENOG41071TK Uncharacterised protein family (UPF0150) EQM13_10370 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) EQM13_10375 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) EQM13_10510 ENOG4108K9K Uncharacterised protein family (UPF0236) EQM13_10515 ENOG4105C4R Atp-dependent dna helicase EQM13_10610 ENOG4105D7M Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) EQM13_10620 ENOG4107QQG Dehydrogenase EQM13_10625 ENOG4105J5G Transferase hexapeptide repeat containing protein EQM13_10640 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase EQM13_10660 ENOG4105D3Q Sugar transferase EQM13_10670 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase EQM13_10690 ENOG4108RB3 Capsular polysaccharide biosynthesis protein EQM13_10695 ENOG4107YJ4 chain length determinant protein EQM13_10700 ENOG4105HTX biosynthesis protein EQM13_10710 ENOG4105CVJ phosphoglycerate mutase EQM13_10745 ENOG4108KXV response regulator EQM13_10760 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) EQM13_10765 ENOG4105CJN penicillin-binding protein EQM13_10770 ENOG4105DBI uridine monophosphokinase EQM13_10775 ENOG4105CFP Peptidase U32 EQM13_10795 ENOG41084CE UPF0342 protein EQM13_10800 ENOG4105CN5 Metallo-Beta-Lactamase EQM13_10805 ENOG4105I3K Ferric uptake regulator, Fur family EQM13_10815 ENOG4108Z08 Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) EQM13_10825 ENOG4105VBH UPF0297 protein EQM13_10830 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) EQM13_10850 ENOG41082EK Restriction modification system DNA (Specificity EQM13_10885 ENOG4107XTC May be involved in the formation or repair of Fe-S clusters present in iron-sulfur proteins EQM13_10915 ENOG4105EXW epimerase dehydratase EQM13_10920 ENOG4105C8T Leucyl-tRNA synthetase EQM13_10930 ENOG4105D1H recombination factor protein RarA EQM13_10935 ENOG4106M28 alanine racemase domain protein EQM13_10945 ENOG4105EQ5 D-Lysine 5,6-aminomutase alpha subunit EQM13_10950 ENOG4105KIJ D-ornithine aminomutase S component EQM13_10955 ENOG4107RH1 pyridoxal-5'-phosphate-dependent protein beta subunit EQM13_10960 ENOG4105Z5Q EQM13_10965 ENOG4108KR4 dihydrodipicolinate reductase EQM13_10970 ENOG4108JUB Transcriptional regulator EQM13_10975 ENOG4105BZU Histidine kinase EQM13_10980 ENOG4105DPZ Two component transcriptional regulator (Winged helix family EQM13_10985 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase EQM13_10990 ENOG4108Z11 Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity) EQM13_10995 ENOG4105WR5 sporulation protein, YlmC YmxH family EQM13_11000 ENOG4105E65 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) EQM13_11005 ENOG4105DAV Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) EQM13_11010 ENOG4105FFI sigma-e processing peptidase spoiiga EQM13_11015 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) EQM13_11020 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) EQM13_11025 ENOG4105K67 small basic protein EQM13_11045 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) EQM13_11055 ENOG4105CNI cell division protein FtsW EQM13_11060 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) EQM13_11065 ENOG4105CPY First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) EQM13_11070 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) EQM13_11075 ENOG4105CJN penicillin-binding protein EQM13_11085 ENOG4105CGJ Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) EQM13_11090 ENOG4108V6E Cell division protein mraZ EQM13_11115 ENOG4105C3G gtp-binding protein EQM13_11125 ENOG4105FCI Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity) EQM13_11130 ENOG4108VPX Involved in 1,2-propanediol (1,2-PD) degradation by catalyzing the conversion of propanoyl-CoA to propanoyl-phosphate (By similarity) EQM13_11145 ENOG4105X71 Membrane EQM13_11160 ENOG4105CDY transcriptional regulatory protein EQM13_11165 ENOG4107RA1 nh(3)-dependent nad( ) synthetase EQM13_11170 ENOG4107QSE Dipeptidase EQM13_11175 ENOG4105HF0 Membrane EQM13_11190 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein EQM13_11200 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) EQM13_11220 ENOG4105CZ3 stage V sporulation protein ad EQM13_11225 ENOG41090VF Stage v sporulation protein ac EQM13_11240 ENOG4105CT2 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) EQM13_11245 ENOG4108ZBE Binds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F). Phosphorylates SpoIIAA on a serine residue. This phosphorylation may enable SpoIIAA to act as an anti-anti-sigma factor that counteracts SpoIIAB and thus releases sigma F from inhibition (By similarity) EQM13_11265 ENOG4105CUZ uba thif-type nad fad binding protein EQM13_11305 ENOG4105EGD dinuclear metal center protein, YbgI family EQM13_11310 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) EQM13_11315 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) EQM13_11320 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) EQM13_11325 ENOG4105C4Q deoxyguanosinetriphosphate triphosphohydrolase-like protein EQM13_11330 ENOG4105CF9 Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation (By similarity) EQM13_11355 ENOG4108SAY Involved in DNA repair and RecF pathway recombination (By similarity) EQM13_11365 ENOG4105KG3 cytidine deaminase EQM13_11370 ENOG4108R5T secreted protein EQM13_11375 ENOG4107YR5 Diacylglycerol kinase EQM13_11385 ENOG4105CTJ Metal Dependent Phosphohydrolase EQM13_11390 ENOG4105C9A Phoh family EQM13_11400 ENOG41068P3 sporulation protein YqfC EQM13_11410 ENOG4105DI5 UPF0365 protein EQM13_11415 ENOG4105F7J membrane-bound serine protease EQM13_11420 ENOG4105KTH gatB Yqey EQM13_11430 ENOG4107YU2 histidine triad (hIT) protein EQM13_11435 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) EQM13_11440 ENOG4107TVK Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) EQM13_11445 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) EQM13_11455 ENOG4105CFG Acts as a chaperone (By similarity) EQM13_11460 ENOG4105K90 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ EQM13_11465 ENOG4105CI8 Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons (By similarity) EQM13_11470 ENOG4105CSA Coproporphyrinogen iii oxidase EQM13_11475 ENOG4105C4S Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) EQM13_11485 ENOG4105C3F Signal peptidase i EQM13_11495 ENOG4105CEF Initiates the rapid degradation of small, acid-soluble proteins during spore germination (By similarity) EQM13_11500 ENOG4105KQV Binds directly to 16S ribosomal RNA (By similarity) EQM13_11505 ENOG4105TQK DNA polymerase iii, delta' subunit EQM13_11510 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 EQM13_11515 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) EQM13_11525 ENOG4108RCM Nitroreductase EQM13_11540 ENOG4105CCG Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity) EQM13_11550 ENOG4105BZG amino acid carrier protein EQM13_11565 ENOG4105BZ1 (ABC) transporter EQM13_11580 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase EQM13_11610 ENOG4105BZU Histidine kinase EQM13_11620 ENOG4105EM7 Selenocysteine-specific translation elongation factor EQM13_11625 ENOG4105C1Y Converts seryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis (By similarity) EQM13_11635 ENOG41083P1 competence protein ComEA helix-hairpin-helix repeat protein EQM13_11640 ENOG4105DZ1 carboxypeptidase EQM13_11645 ENOG4105KME endoribonuclease L-psp EQM13_11660 ENOG4108WF2 Metal Dependent Phosphohydrolase EQM13_11680 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control EQM13_11685 ENOG4105K46 50S ribosomal protein l27 EQM13_11700 ENOG4105C03 ribonuclease EQM13_11720 ENOG41083CN Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell (By similarity) EQM13_11725 ENOG4107QMS site-determining protein EQM13_11735 ENOG4107RF6 penicillin-binding protein EQM13_11750 ENOG4105DFF Rod shape-determining protein mreb EQM13_11755 ENOG4105W5Q DNA repair protein (RadC EQM13_11795 ENOG4108ZBE Binds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F). Phosphorylates SpoIIAA on a serine residue. This phosphorylation may enable SpoIIAA to act as an anti-anti-sigma factor that counteracts SpoIIAB and thus releases sigma F from inhibition (By similarity) EQM13_11810 ENOG4105C19 ABC transporter EQM13_11815 ENOG4105EWM Histidine kinase EQM13_11820 ENOG4105CJZ response regulator EQM13_11840 ENOG4105DPZ Two component transcriptional regulator (Winged helix family EQM13_11900 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) EQM13_11905 ENOG4105C2M dna polymerase I EQM13_11925 ENOG4105BZ1 (ABC) transporter EQM13_11945 ENOG4105DAS pts system EQM13_11950 ENOG4108RTU Aldolase EQM13_11965 ENOG4105D7N magnesium and cobalt transport protein CorA EQM13_12005 ENOG4105CJ1 ABC, transporter EQM13_12020 ENOG4105BZ1 (ABC) transporter EQM13_12025 ENOG4105BZ1 (ABC) transporter EQM13_12030 ENOG4105CAQ asparagine synthetase EQM13_12040 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) EQM13_12050 ENOG4105DF9 Lipoate-protein, ligase EQM13_12055 ENOG4108IFG nitrite reductase, (NAD(P)H) EQM13_12060 ENOG4107RUE extracellular solute-binding protein family 1 EQM13_12065 ENOG4105D38 putrescine abc transporter EQM13_12070 ENOG4105F38 ABC transporter, permease EQM13_12075 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) EQM13_12080 ENOG4108JCI Transcriptional regulator EQM13_12090 ENOG4108V0P LemA family EQM13_12105 ENOG4105D8I Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS (By similarity) EQM13_12110 ENOG4107QI6 Cysteine desulfurase EQM13_12115 ENOG4105HDK L-asparaginase EQM13_12135 ENOG4105CYC Transferase EQM13_12140 ENOG4105HKU nucleoside recognition domain-containing protein EQM13_12145 ENOG4105HKU nucleoside recognition domain-containing protein EQM13_12160 ENOG4105CIZ coA-substrate-specific enzyme activase EQM13_12325 ENOG4105DUM transcriptional regulator, lysR family EQM13_12330 ENOG4105DFM M18 family aminopeptidase EQM13_12335 ENOG4105WH1 Two component transcriptional regulator luxr family EQM13_12345 ENOG4108V3W Chemotaxis protein, CheW EQM13_12355 ENOG4105ETE Transcriptional regulator (LacI family EQM13_12360 ENOG4105BZU Histidine kinase EQM13_12365 ENOG41067TZ transcriptional regulator, MarR family EQM13_12370 ENOG4105CBD Diacylglycerol kinase EQM13_12380 ENOG4105BZ1 (ABC) transporter EQM13_12385 ENOG4105BZ1 (ABC) transporter EQM13_12390 ENOG4107RVV histidinol phosphate phosphatase, hisj family EQM13_12395 ENOG4108NGU Transcriptional regulator EQM13_12420 ENOG4105C28 cystathionine EQM13_12430 ENOG4105C3E May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine (By similarity) EQM13_12435 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) EQM13_12450 ENOG4107U9W Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S- specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX (By similarity) EQM13_12465 ENOG4105IU0 Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) EQM13_12470 ENOG4105D22 carbon starvation protein EQM13_12485 ENOG4105EMS pseudouridine synthase EQM13_12490 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) EQM13_12495 ENOG4105DPN Oligoendopeptidase f EQM13_12500 ENOG4105CJN penicillin-binding protein EQM13_12510 ENOG4105HZM Fha domain containing protein EQM13_12520 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) EQM13_12535 ENOG4107X4V Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) EQM13_12565 ENOG4105DYN CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. May be involved in the integration of spacer DNA into the CRISPR cassette (By similarity) EQM13_12605 ENOG4105CHJ isochorismatase hydrolase EQM13_12610 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen EQM13_12620 ENOG4105C5H ABC transporter EQM13_12630 ENOG4105PTV Nudix Hydrolase EQM13_12655 ENOG4108IUW ABC transporter EQM13_12670 ENOG4105CJ1 ABC, transporter EQM13_12690 ENOG4108TYN CAAX amino terminal protease family protein EQM13_12735 ENOG4107Y80 Major Facilitator superfamily EQM13_12750 ENOG4105BZ1 (ABC) transporter EQM13_12810 ENOG4108NEV two component transcriptional regulator, LytTR family EQM13_12820 ENOG4107QIZ NADH dehydrogenase EQM13_12825 ENOG410902H NADH dehydrogenase (Ubiquinone), 24 kDa subunit EQM13_12830 ENOG4108K9K Uncharacterised protein family (UPF0236) EQM13_12835 ENOG4105E2V Glycosyltransferase 36 EQM13_12845 ENOG4105BZ1 (ABC) transporter EQM13_12850 ENOG4105BZ1 (ABC) transporter EQM13_12865 ENOG4105C1V Peptidase, M16 EQM13_12900 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) EQM13_12910 ENOG4105CVA phosphate EQM13_12920 ENOG4107VEG TrkA-N domain protein EQM13_12935 ENOG4108UH4 Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity) EQM13_12940 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) EQM13_12945 ENOG4105CPF Cell wall formation (By similarity) EQM13_12950 ENOG4107EES Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity) EQM13_12970 ENOG4105CJI Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) EQM13_12975 ENOG4105CP7 Triose-phosphate isomerase EQM13_12980 ENOG4105BZA Phosphoglycerate kinase EQM13_12995 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) EQM13_13015 ENOG4108ESE uses NADH to detoxify nitric oxide (NO), protecting several 4Fe-4S NO-sensitive enzymes. Has at least 2 reductase partners, only one of which (NorW, flavorubredoxin reductase) has been identified. NO probably binds to the di-iron center EQM13_13020 ENOG4108Z0Z intracellular protease Pfpi family EQM13_13030 ENOG4105UIB (ABC) transporter EQM13_13035 ENOG4108JQ9 ABC transporter EQM13_13040 ENOG4107TFB basic membrane EQM13_13065 ENOG4105EZ5 reductase EQM13_13070 ENOG41080XV Thioredoxin EQM13_13085 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) EQM13_13090 ENOG410667J hydrolase EQM13_13095 ENOG4105E0A ABC, transporter EQM13_13100 ENOG4105EHG Permease protein EQM13_13105 ENOG4105JKQ Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity) EQM13_13120 ENOG41073R8 VanW family EQM13_13125 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) EQM13_13130 ENOG4105CSM endonuclease III EQM13_13140 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) EQM13_13145 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) EQM13_13150 ENOG4105CNI cell division protein FtsW EQM13_13160 ENOG4105C5I Dehydrogenase EQM13_13195 ENOG4105EFP binding-protein-dependent transport systems inner membrane Component EQM13_13210 ENOG4105TMB Formate nitrite transporter EQM13_13215 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) EQM13_13220 ENOG410908R Methenyltetrahydrofolate cyclohydrolase EQM13_13225 ENOG4105CKU formyltetrahydrofolate synthetase EQM13_13230 ENOG4105W4W Transcriptional regulator EQM13_13235 ENOG4108KHS signal transduction Histidine kinase EQM13_13245 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) EQM13_13255 ENOG4105C28 cystathionine EQM13_13260 ENOG4105C59 p-type ATPase EQM13_13265 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase EQM13_13270 ENOG4105C4R Atp-dependent dna helicase EQM13_13285 ENOG4105MN5 HAD-superfamily hydrolase subfamily IA variant 3 EQM13_13310 ENOG4105EPR degv family EQM13_13325 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) EQM13_13335 ENOG4105CM2 brancheD-chain amino acid aminotransferase EQM13_13345 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) EQM13_13350 ENOG4105CI3 gtp-binding protein typa EQM13_13360 ENOG4105BZ1 (ABC) transporter EQM13_13385 ENOG4105C4X radical SAM domain protein EQM13_13400 ENOG4108IV0 ABC, transporter EQM13_13405 ENOG4105C0Z ABC transporter EQM13_13410 ENOG4105CF8 branched-chain amino acid ABC transporter, permease EQM13_13415 ENOG4105C32 Amino acid ABC transporter (Permease) EQM13_13420 ENOG4105CP9 extracellular ligand-binding receptor EQM13_13435 ENOG4105DG6 mannose-6-phosphate isomerase EQM13_13440 ENOG4105DG6 mannose-6-phosphate isomerase EQM13_13445 ENOG4105F3R pts system mannose fructose sorbose family iid EQM13_13450 ENOG4108IQ3 PTS system EQM13_13460 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism EQM13_13480 ENOG4105WHM Necessary for normal cell division and for the maintenance of normal septation (By similarity) EQM13_13485 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) EQM13_13490 ENOG4105CHN ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) EQM13_13495 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) EQM13_13500 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation EQM13_13515 ENOG4108JQ7 (ABC) transporter EQM13_13520 ENOG4105C3U ABC transporter EQM13_13525 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component EQM13_13535 ENOG4105DEF Extracellular solute-binding protein, family 5 EQM13_13555 ENOG4108RAC Rubrerythrin EQM13_13560 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase EQM13_13580 ENOG4105D9U N-acetyltransferase EQM13_13595 ENOG4105C02 permease EQM13_13600 ENOG4105EC8 Methyl-accepting chemotaxis EQM13_13720 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) EQM13_13795 ENOG4105PFA Catalyzes the conversion of 5-hydroxyuridine (ho5U) to 5-methoxyuridine (mo5U) at position 34 in tRNA (By similarity) EQM13_13815 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) EQM13_13820 ENOG4107QJF Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) EQM13_13825 ENOG4105D4J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate EQM13_13830 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) EQM13_13835 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) EQM13_13840 ENOG4105CHR reductase EQM13_13845 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase EQM13_13850 ENOG4105EA8 2-Nitropropane dioxygenase EQM13_13855 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) EQM13_13865 ENOG4105CE4 GlcNAc 6-P deacetylase EQM13_13875 ENOG4105F3R pts system mannose fructose sorbose family iid EQM13_13880 ENOG4105ETZ PTS System EQM13_13885 ENOG4108UZY PTS System EQM13_13890 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family EQM13_13900 ENOG4105C6T cysteine synthase EQM13_13915 ENOG4105CEM UPF0597 protein EQM13_13940 ENOG4105D1F ATP-binding protein EQM13_13945 ENOG4105CKM Branched-chain carboxylic acid kinase EQM13_13950 ENOG4107RE7 phosphate butyryltransferase EQM13_13955 ENOG4105CKM Branched-chain carboxylic acid kinase EQM13_13965 ENOG4105C8B TIGR00159 family EQM13_13985 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) EQM13_13990 ENOG4105KRI phosphocarrier protein (HPr EQM13_14010 ENOG4105D9Q decarboxylase (Beta subunit) EQM13_14015 ENOG4105E4Z Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity) EQM13_14030 ENOG410787A Pts system, glucitol sorbitol-specific EQM13_14035 ENOG4105DZY Pts system, glucitol sorbitol-specific EQM13_14050 ENOG4105D2N Aldolase EQM13_14115 ENOG4105CPQ Dehydrogenase EQM13_14120 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) EQM13_14125 ENOG4108JQ1 Dehydrogenase EQM13_14130 ENOG4105F3R pts system mannose fructose sorbose family iid EQM13_14140 ENOG4105KPI PTS system sorbose subfamily IIB component EQM13_14150 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family EQM13_14165 ENOG4105C8E extradiol ring-cleavage dioxygenase class IIi protein subunit b EQM13_14170 ENOG4105BZ1 (ABC) transporter EQM13_14175 ENOG4105BZ1 (ABC) transporter EQM13_14200 ENOG4105Y5S NADH ubiquinone oxidoreductase, 24 kD EQM13_14205 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase EQM13_14210 ENOG4105CKI cobalamin synthesis protein EQM13_14230 ENOG4108UJD 30S ribosomal protein S9 EQM13_14240 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) EQM13_14245 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) EQM13_14250 ENOG4108JJB ABC transporter EQM13_14255 ENOG4108JJB ABC transporter EQM13_14260 ENOG4108ZT0 50S ribosomal protein l17 EQM13_14265 ENOG4105CTF DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) EQM13_14270 ENOG4105G6W One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) EQM13_14275 ENOG4108UHH Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) EQM13_14280 ENOG4108Z04 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits EQM13_14285 ENOG41067V7 50S ribosomal protein L36 EQM13_14305 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) EQM13_14310 ENOG4108UZ0 Binds to the 23S rRNA (By similarity) EQM13_14315 ENOG4105VPB 50S ribosomal protein L30 EQM13_14320 ENOG4108RA9 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) EQM13_14325 ENOG4105K4C This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity) EQM13_14330 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) EQM13_14335 ENOG4108UJY One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity) EQM13_14340 ENOG41082QR Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) EQM13_14350 ENOG4105KAR One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity) EQM13_14360 ENOG4105K87 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal EQM13_14365 ENOG41082SA 50s ribosomal protein l29 EQM13_14370 ENOG4108R70 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity) EQM13_14375 ENOG4105CKE Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) EQM13_14380 ENOG4105KAP The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity) EQM13_14385 ENOG4105K7S Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity) EQM13_14395 ENOG41080UE One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity) EQM13_14400 ENOG4106U5A One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) EQM13_14415 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) EQM13_14425 ENOG4108UHY One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity) EQM13_14430 ENOG4108UKE Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity) EQM13_14435 ENOG4105XPM ribosomal protein EQM13_14440 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) EQM13_14445 ENOG4108IIJ DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) EQM13_14455 ENOG4108VZM 50s ribosomal protein L10 EQM13_14470 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) EQM13_14475 ENOG410683Z Preprotein translocase SecE subunit EQM13_14480 ENOG4105WDJ 50S ribosomal protein L33 EQM13_14485 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) EQM13_14495 ENOG4105QIV RNA polymerase EQM13_14500 ENOG4105M0M Tetracycline resistance protein EQM13_14505 ENOG4105C2N RNA methyltransferase TrmH family group 3 EQM13_14510 ENOG41087GE Catalyzes the formation of dTMP and tetrahydrofolate from dUMP and methylenetetrahydrofolate (By similarity) EQM13_14515 ENOG4105KEB Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc) EQM13_14525 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) EQM13_14535 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) EQM13_14545 ENOG4105CE5 Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity) EQM13_14550 ENOG4105CTP PilT protein domain protein EQM13_14555 ENOG4108VJ1 Transcriptional regulator (CarD family EQM13_14570 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) EQM13_14575 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit EQM13_14580 ENOG41066A3 ATP guanido phosphotransferase EQM13_14585 ENOG4108Z0C Uvrb UvrC protein EQM13_14590 ENOG4105KEX transcriptional regulator, ctsr EQM13_14595 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) EQM13_14600 ENOG4105CIH Imidazole acetol-phosphate transaminase EQM13_14605 ENOG4108IV0 ABC, transporter EQM13_14610 ENOG4105C0Z ABC transporter EQM13_14615 ENOG4105CF8 branched-chain amino acid ABC transporter, permease EQM13_14620 ENOG4105C32 Amino acid ABC transporter (Permease) EQM13_14625 ENOG4105CP9 extracellular ligand-binding receptor EQM13_14645 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) EQM13_14650 ENOG4107QN2 dihydrolipoyl dehydrogenase EQM13_14655 ENOG4105C7S Dehydrogenase EQM13_14660 ENOG4105CPP Dehydrogenase, E1 component EQM13_14665 ENOG4107RUY (E1 component), alpha subunit EQM13_14680 ENOG4105DZY Pts system, glucitol sorbitol-specific EQM13_14685 ENOG410787A Pts system, glucitol sorbitol-specific EQM13_14690 ENOG4105J92 DNA-binding transcriptional activator GutM EQM13_14695 ENOG4107RHR regulatoR EQM13_14700 ENOG410667J hydrolase EQM13_14705 ENOG4105CBX hi0933 family EQM13_14710 ENOG4108KR4 dihydrodipicolinate reductase EQM13_14715 ENOG4108Z5V transcriptional regulator, merr family EQM13_14755 ENOG4108UN4 phage SPO1 DNA polymerase-related protein EQM13_14760 ENOG4108UN4 phage SPO1 DNA polymerase-related protein EQM13_14765 ENOG4105CRK lysyL-tRNA synthetase EQM13_14770 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) EQM13_14780 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) EQM13_14785 ENOG4105CGM Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis (By similarity) EQM13_14795 ENOG4105KXX peptidase s58 dmpa EQM13_14800 ENOG4105D9Q decarboxylase (Beta subunit) EQM13_14805 ENOG4105PV1 biotin lipoyl attachment domaiN-containing protein EQM13_14820 ENOG4108ZVT methylmalonyl-coA epimerase EQM13_14840 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) EQM13_14850 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) EQM13_14855 ENOG4105D9P serine threonine protein kinase EQM13_14880 ENOG4105BZU Histidine kinase EQM13_14885 ENOG4105CK6 Two component transcriptional regulator (Winged helix family EQM13_14890 ENOG4105G3A stage ii sporulation protein e EQM13_14895 ENOG41060GV RNA binding s1 domain protein EQM13_14910 ENOG4105VYY sporulation protein yabp EQM13_14915 ENOG41082I2 s4 domain protein EQM13_14920 ENOG4105K70 DNA-binding protein EQM13_14925 ENOG4108IY2 MazG family EQM13_14935 ENOG4108M14 stage v sporulation protein t EQM13_14940 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) EQM13_14945 ENOG4108JA2 transcriptioN-repair coupling factor EQM13_14955 ENOG4105C5T Phosphoribosyl pyrophosphate synthase EQM13_14970 ENOG4105DFT pur operon repressor EQM13_14975 ENOG4105DFU Cell wall formation (By similarity) EQM13_14980 ENOG4108KGH TRANSCRIPTIONal EQM13_14985 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase EQM13_14990 ENOG4105E39 Enoyl-CoA hydratase EQM13_15000 ENOG4107QYV phosphohexose isomerase EQM13_15020 ENOG4105C8Q Methyl-accepting chemotaxis EQM13_15030 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) EQM13_15035 ENOG4108YZ8 Superoxide reductase EQM13_15040 ENOG4105CYC Transferase EQM13_15045 ENOG410749K Uncharacterized protein conserved in bacteria (DUF2179) EQM13_15050 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) EQM13_15055 ENOG4105K4I Scp-like extracellular EQM13_15060 ENOG4105P8F nudix hydrolase EQM13_15080 ENOG4105E4R Precorrin-3B C17-methyltransferase EQM13_15085 ENOG4105CIH Imidazole acetol-phosphate transaminase EQM13_15095 ENOG4105D78 K07001 NTE family protein EQM13_15105 ENOG4108IGT Dipeptidase EQM13_15120 ENOG4108UMW Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) EQM13_15130 ENOG4105EMU Dehydrogenase EQM13_15135 ENOG4108UHU Aldolase EQM13_15140 ENOG4105C5I Dehydrogenase EQM13_15150 ENOG4105CE4 GlcNAc 6-P deacetylase EQM13_15165 ENOG4105CK5 oxidoreductase EQM13_15170 ENOG4108SU4 UPF0309 protein EQM13_15175 ENOG4105DAS pts system EQM13_15180 ENOG4105F3R pts system mannose fructose sorbose family iid EQM13_15195 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family EQM13_15200 ENOG4105FDP GntR family transcriptional regulator EQM13_15215 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) EQM13_15220 ENOG4105F3R pts system mannose fructose sorbose family iid EQM13_15225 ENOG4105ETZ PTS System EQM13_15230 ENOG4108UZY PTS System EQM13_15235 ENOG4105FCI Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity) EQM13_15240 ENOG4105DJV ribulose-phosphate 3-epimerase EQM13_15245 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) EQM13_15255 ENOG4105C9S Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P) (By similarity) EQM13_15260 ENOG4105DM4 PTS System EQM13_15265 ENOG4108X4Q Hydrolase EQM13_15275 ENOG4105F1A Pyruvate formate-lyase EQM13_15280 ENOG4105C6N Formate acetyltransferase EQM13_15320 ENOG4107QMH DNA methylase EQM13_15345 ENOG4105C7Z Conserved Protein EQM13_15370 ENOG4105DPZ Two component transcriptional regulator (Winged helix family EQM13_15375 ENOG4105BZU Histidine kinase EQM13_15390 ENOG4105FGV Chromate EQM13_15395 ENOG4105X1N Glycosyl transferase family 8 EQM13_15420 ENOG4105EFU Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin (By similarity) EQM13_15425 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) EQM13_15445 ENOG4108V3G Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) EQM13_15475 ENOG4105BZ1 (ABC) transporter EQM13_15480 ENOG4105BZ1 (ABC) transporter EQM13_15500 ENOG4105DEU major facilitator superfamily EQM13_15505 ENOG4105D70 Integrase catalytic subunit EQM13_15510 ENOG4105F5W AtP-binding protein EQM13_15535 ENOG4105BZ1 (ABC) transporter EQM13_15545 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) EQM13_15625 ENOG4108Q52 Methyltransferase cognate corrinoid protein EQM13_15630 ENOG4107RBB ABC transporter, permease EQM13_15640 ENOG4105BZU Histidine kinase EQM13_15675 ENOG4105II7 pyrroline-5-carboxylate reductase EQM13_15680 ENOG4105DC7 peptidase M24 EQM13_15690 ENOG4105JVQ RNA Polymerase EQM13_15710 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) EQM13_15720 ENOG4105D8J Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle (By similarity) EQM13_15740 ENOG4105R8C Transcriptional regulator EQM13_15795 ENOG4106N3A copper homeostasis protein cutc EQM13_15805 ENOG4105C5Y PTS System EQM13_15820 ENOG4105C5Y PTS System EQM13_15825 ENOG4105CID antiterminator EQM13_15830 ENOG4105CI1 PTS System EQM13_15840 ENOG4105CJ1 ABC, transporter EQM13_15900 ENOG41067QW Transcriptional regulator EQM13_15955 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) EQM13_15960 ENOG41067QW Transcriptional regulator EQM13_16000 ENOG4108C33 Resolvase EQM13_16045 ENOG4107TXC Transcriptional regulator EQM13_16055 ENOG4105CI4 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) EQM13_16080 ENOG4105DZR Type I site-specific deoxyribonuclease EQM13_16090 ENOG4105EKX Restriction modification system DNA (Specificity EQM13_16095 ENOG4105CVR type I restriction-modification system EQM13_16105 ENOG4107V6I Cytosine-specific methyltransferase EQM13_16110 ENOG4105PZN Type II restriction enzyme NlaIV EQM13_16155 ENOG4105C2M dna polymerase I EQM13_16210 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP EQM13_16255 ENOG4105CAR Terminase, large subunit EQM13_16265 ENOG4105EFC phage portal protein HK97 family EQM13_16270 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) EQM13_16340 ENOG4105XSJ toxin secretion phage lysis holin EQM13_16370 ENOG4105DQ6 Transposase EQM13_16375 ENOG4105EKQ RNA-directed DNA polymerase EQM13_16405 ENOG4105CVR type I restriction-modification system EQM13_16415 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) EQM13_16425 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) EQM13_16435 ENOG4107SQC 5-methylcytosine-specific restriction enzyme subunit McrC EQM13_16440 ENOG4105FBQ ATPase associated with various cellular activities aaa_5 EQM13_16455 ENOG4105DVT helicase EQM13_16475 ENOG4108SU4 UPF0309 protein EQM13_16490 ENOG4105F3R pts system mannose fructose sorbose family iid EQM13_16495 ENOG4105ETZ PTS System EQM13_16500 ENOG4105DAS pts system EQM13_16515 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family EQM13_16520 ENOG4105PUK Membrane EQM13_16530 ENOG4105YPM F pilin acetylation protein TraX EQM13_16550 ENOG4105HF9 Inherit from COG: pyridine nucleotide-disulfide oxidoreductase EQM13_16560 ENOG4108JQ7 (ABC) transporter EQM13_16570 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component EQM13_16575 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component EQM13_16605 ENOG4105CZV ABC transporter EQM13_16610 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family EQM13_16620 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) EQM13_16695 ENOG4105C7R Atpase associated with various cellular activities aaa_3 EQM13_16720 ENOG4105CJD (Anaerobic) ribonucleoside-triphosphate reductase EQM13_16760 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) EQM13_16765 ENOG4108S10 Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) EQM13_16775 ENOG4106V2I dimethylaminohydrolase EQM13_16795 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) EQM13_16830 ENOG4105CJ1 ABC, transporter EQM13_16835 ENOG4105BZ1 (ABC) transporter EQM13_16845 ENOG4105BZ1 (ABC) transporter EQM13_16860 ENOG4105DA5 (ABC) transporter EQM13_16875 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) EQM13_16895 ENOG4106UJV Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP) (By similarity) EQM13_16900 ENOG4108VX5 3-methyladenine DNA glycosylase EQM13_16920 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B EQM13_16930 ENOG4105C26 Dehydrogenase EQM13_16950 ENOG4105DZY Pts system, glucitol sorbitol-specific EQM13_16960 ENOG410787A Pts system, glucitol sorbitol-specific EQM13_16975 ENOG4105CHR reductase EQM13_17000 ENOG41068JE domain protein EQM13_17010 ENOG4105DFD Na H antiporter EQM13_17015 ENOG4105N5T Radical SAM Protein EQM13_17025 ENOG4105CPQ Dehydrogenase EQM13_17030 ENOG4107QW4 alcohol dehydrogenase EQM13_17045 ENOG4108PJD permease EQM13_17060 ENOG4105FAV ABC, transporter EQM13_17065 ENOG4105FDK ABC transporter EQM13_17070 ENOG4105DSE periplasmic solute binding protein EQM13_17090 ENOG4105C1J atp-dependent rna helicase EQM13_17095 ENOG4105PXI polysaccharide deacetylase EQM13_17125 ENOG4105JVQ RNA Polymerase EQM13_17145 ENOG4108Z66 YbaK ebsC protein EQM13_17165 ENOG4108K9K Uncharacterised protein family (UPF0236) EQM13_17235 ENOG4105EMN RNA polymerase sigma factor EQM13_17245 ENOG410841Q phosphoesterase PA-phosphatase related protein EQM13_17250 ENOG4107T5V SNARE associated Golgi EQM13_17255 ENOG4105EEX Two component transcriptional regulator (Winged helix family EQM13_17320 ENOG4105C19 ABC transporter EQM13_17325 ENOG4105BZU Histidine kinase EQM13_17330 ENOG4108KXV response regulator EQM13_17350 ENOG41065SU Two-component system sensor kinase EQM13_17355 ENOG4105CK6 Two component transcriptional regulator (Winged helix family EQM13_17360 ENOG4105C4R Atp-dependent dna helicase EQM13_17430 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) EQM13_17440 ENOG4105EJ7 Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O (By similarity) EQM13_17460 ENOG4108TVJ Nitroreductase EQM13_17470 ENOG4105C5H ABC transporter EQM13_17475 ENOG4105ER2 Ompa motb domain protein EQM13_17480 ENOG4107R0U MotA TolQ exbB proton channel EQM13_17485 ENOG4105C5H ABC transporter EQM13_17495 ENOG4105DXH Alcohol dehydrogenase zinc-binding domain protein EQM13_17500 ENOG4105DE4 1-phosphofructokinase EQM13_17510 ENOG4105ETD TRANSCRIPTIONal EQM13_17515 ENOG4105CTS PTS system mannitol-specific EQM13_17530 ENOG4105DTZ bifunctional PTS system fructose-specific transporter subunit IIA HPr protein EQM13_17545 ENOG4108SU4 UPF0309 protein EQM13_17550 ENOG4107XJU UPF0178 protein EQM13_17555 ENOG4105C9U ATP-dependent DNA helicase RecQ EQM13_17570 ENOG4108BDP Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity) EQM13_17585 ENOG4105CK6 Two component transcriptional regulator (Winged helix family EQM13_17590 ENOG4105GR3 Histidine kinase EQM13_17595 ENOG4108UTW Plays a role in the regulation of phosphate uptake EQM13_17600 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) EQM13_17610 ENOG4105C8U phosphate abc transporter EQM13_17615 ENOG4105CVA phosphate EQM13_17630 ENOG4108SDH ABC, transporter EQM13_17635 ENOG4108IUW ABC transporter EQM13_17645 ENOG4108UT2 hemolysin iii EQM13_17655 ENOG4105CGK Exodeoxyribonuclease III EQM13_17660 ENOG4105F9U Dehydrogenase EQM13_17670 ENOG4105CB3 Required for the thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32) (By similarity) EQM13_17675 ENOG4105CSD Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) (By similarity) EQM13_17685 ENOG4105C2N RNA methyltransferase TrmH family group 3 EQM13_17690 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) EQM13_17710 ENOG41088YA Catalyzes the GTP-dependent successive addition of two or more gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form coenzyme F420-0-glutamyl-glutamate (F420-2) or polyglutamated F420 derivatives (By similarity) EQM13_17735 ENOG4105DC7 peptidase M24 EQM13_17740 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component EQM13_17750 ENOG4108JQ7 (ABC) transporter EQM13_17800 ENOG4105Q2H domain protein EQM13_17825 ENOG4105BZU Histidine kinase EQM13_17845 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin EQM13_17850 ENOG4105DR5 peptidase EQM13_17870 ENOG4108ZDA Sporulation protein YyaC EQM13_17880 ENOG4105CBD Diacylglycerol kinase EQM13_17895 ENOG4105CPN adenine deaminase EQM13_17920 ENOG4108SER Transposase EQM13_17925 ENOG4105DQ6 Transposase EQM13_17930 ENOG4105EKQ RNA-directed DNA polymerase EQM13_17990 ENOG4105DA5 (ABC) transporter EQM13_17995 ENOG4107QHI -hydrogenase EQM13_18000 ENOG4107QIZ NADH dehydrogenase EQM13_18010 ENOG410902H NADH dehydrogenase (Ubiquinone), 24 kDa subunit EQM13_18015 ENOG4105JAB phenazine biosynthesis protein, phzf family EQM13_18020 ENOG4105FA0 parb-like partition protein EQM13_18025 ENOG4107QJE Chromosome Partitioning Protein EQM13_18035 ENOG4105D28 Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity) EQM13_18040 ENOG4107RE5 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) EQM13_18045 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) EQM13_18050 ENOG4108Z7S Single-stranded nucleic acid binding R3H domain-containing protein EQM13_18055 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins EQM13_18060 ENOG4105VAS Could be involved in insertion of integral membrane proteins into the membrane (By similarity) EQM13_18065 ENOG4105M7T RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity) EQM13_18070 ENOG4105VG0 50S ribosomal protein l34