locus-tag	class	description
TMO_0001	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
TMO_0002	COG0592	DNA-directed DNA polymerase activity
TMO_0003	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
TMO_0004	COG0187	DNA topoisomerase II activity
TMO_0007	COG3384	dioxygenase
TMO_0008	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
TMO_0009	COG2814	Major facilitator Superfamily
TMO_0010	COG0372	Belongs to the citrate synthase family
TMO_0011	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
TMO_0013	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
TMO_0016	COG1177	transmembrane transport
TMO_0017	COG1176	ABC-type spermidine putrescine transport system, permease component I
TMO_0018	COG3842	ATPase activity
TMO_0020	COG0842	Transport permease protein
TMO_0021	COG1131	(ABC) transporter
TMO_0024	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
TMO_0026	COG0745	RESPONSE REGULATOR receiver
TMO_0027	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
TMO_0028	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
TMO_0029	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
TMO_0030	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
TMO_0032	COG1414	Transcriptional regulator
TMO_0038	COG1028	Short-chain dehydrogenase reductase Sdr
TMO_0065	COG3620	sequence-specific DNA binding
TMO_0081	COG0114	fumarate hydratase activity
TMO_0085	COG0181	hydroxymethylbilane synthase activity
TMO_0086	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
TMO_0092	COG2350	Protein conserved in bacteria
TMO_0095	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
TMO_0099	COG5508	conserved small protein
TMO_0105	COG0719	Fe-S assembly protein
TMO_0106	COG0396	ATPase activity
TMO_0107	COG0719	Fe-S assembly protein
TMO_0108	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
TMO_0110	COG2151	metal-sulfur cluster biosynthetic enzyme
TMO_0123	COG2086	electron transfer activity
TMO_0125	COG1250	3-hydroxyacyl-CoA dehydrogenase
TMO_0126	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
TMO_0127	COG0165	Argininosuccinate lyase
TMO_0128	COG0019	diaminopimelate decarboxylase activity
TMO_0131	COG2884	Cell division ATP-binding protein ftsE
TMO_0139	COG0287	Prephenate dehydrogenase
TMO_0142	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
TMO_0143	COG2813	Specifically methylates the guanine in position
TMO_0143	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
TMO_0144	COG2202	Pas domain
TMO_0144	COG2205	protein histidine kinase activity
TMO_0145	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
TMO_0146	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
TMO_0149	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
TMO_0150	COG0625	glutathione transferase activity
TMO_0161	COG4120	Belongs to the binding-protein-dependent transport system permease family
TMO_0165	COG2917	probably involved in intracellular septation
TMO_0166	COG0552	protein localization to endoplasmic reticulum
TMO_0167	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
TMO_0168	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
TMO_0169	COG2205	protein histidine kinase activity
TMO_0170	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
TMO_0172	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
TMO_0172	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
TMO_0173	COG1660	Displays ATPase and GTPase activities
TMO_0174	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
TMO_0175	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
TMO_0176	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
TMO_0177	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
TMO_0178	COG1137	ATPase activity
TMO_0182	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
TMO_0186	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
TMO_0189	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
TMO_0191	COG0488	(ABC) transporter
TMO_0194	COG0859	PFAM glycosyl transferase family 9
TMO_0195	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
TMO_0196	COG0291	Belongs to the bacterial ribosomal protein bL35 family
TMO_0197	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
TMO_0198	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
TMO_0204	COG0640	Transcriptional regulator
TMO_0205	COG0288	reversible hydration of carbon dioxide
TMO_0214	COG0840	transmembrane signaling receptor activity
TMO_0215	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
TMO_0216	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
TMO_0217	COG1522	sequence-specific DNA binding
TMO_0222	COG2814	Major facilitator Superfamily
TMO_0223	COG1028	Short-chain dehydrogenase reductase Sdr
TMO_0226	COG0318	PFAM AMP-dependent synthetase and ligase
TMO_0229	COG0840	transmembrane signaling receptor activity
TMO_0230	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
TMO_0231	COG0583	DNA-binding transcription factor activity
TMO_0236	COG0412	Dienelactone hydrolase
TMO_0237	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
TMO_0243	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
TMO_0246	COG0583	DNA-binding transcription factor activity
TMO_0248	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
TMO_0250	COG1846	Transcriptional regulator
TMO_0251	COG2267	carboxylic ester hydrolase activity
TMO_0254	COG2832	Protein of unknown function (DUF454)
TMO_0255	COG0753	catalase activity
TMO_0257	COG2814	Major facilitator Superfamily
TMO_0260	COG1230	cation diffusion facilitator family transporter
TMO_0262	COG0583	DNA-binding transcription factor activity
TMO_0270	COG0747	negative chemotaxis
TMO_0272	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
TMO_0273	COG4172	Belongs to the ABC transporter superfamily
TMO_0274	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
TMO_0276	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
TMO_0277	COG2244	polysaccharide biosynthetic process
TMO_0281	COG2186	Transcriptional regulator
TMO_0283	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
TMO_0286	COG1024	Enoyl-CoA hydratase
TMO_0287	COG1177	transmembrane transport
TMO_0288	COG1176	ABC-type spermidine putrescine transport system, permease component I
TMO_0289	COG3842	ATPase activity
TMO_0291	COG0174	glutamine synthetase
TMO_0292	COG4608	Belongs to the ABC transporter superfamily
TMO_0297	COG3191	aminopeptidase activity
TMO_0303	COG0412	Dienelactone hydrolase
TMO_0306	COG0012	GTP binding
TMO_0307	COG0193	aminoacyl-tRNA hydrolase activity
TMO_0308	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
TMO_0309	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
TMO_0311	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
TMO_0317	COG0640	Transcriptional regulator
TMO_0318	COG0227	Belongs to the bacterial ribosomal protein bL28 family
TMO_0319	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
TMO_0320	COG3604	Transcriptional regulator
TMO_0321	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
TMO_0321	COG1116	anion transmembrane transporter activity
TMO_0323	COG1116	anion transmembrane transporter activity
TMO_0324	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
TMO_0327	COG0559	Belongs to the binding-protein-dependent transport system permease family
TMO_0329	COG1137	ATPase activity
TMO_0331	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
TMO_0332	COG1396	sequence-specific DNA binding
TMO_0334	COG4683	PFAM Phage derived protein Gp49-like (DUF891)
TMO_0338	COG1396	sequence-specific DNA binding
TMO_0343	COG4536	flavin adenine dinucleotide binding
TMO_0344	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
TMO_0345	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
TMO_0348	COG4974	Belongs to the 'phage' integrase family
TMO_0350	COG2301	Belongs to the HpcH HpaI aldolase family
TMO_0354	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
TMO_0355	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
TMO_0356	COG0494	nUDIX hydrolase
TMO_0357	COG2226	methyltransferase
TMO_0360	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
TMO_0361	COG1346	cytolysis
TMO_0362	COG1380	Effector of murein hydrolase LrgA
TMO_0363	COG0583	DNA-binding transcription factor activity
TMO_0364	COG2814	Major facilitator Superfamily
TMO_0374	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
TMO_0375	COG0527	aspartate kinase activity
TMO_0376	COG3605	phosphoenolpyruvate-protein phosphotransferase activity
TMO_0378	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
TMO_0379	COG0124	histidyl-tRNA synthetase
TMO_0380	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
TMO_0381	COG2890	protein-(glutamine-N5) methyltransferase activity
TMO_0384	COG0542	response to heat
TMO_0385	COG0739	heme binding
TMO_0387	COG1349	DNA-binding transcription factor activity
TMO_0388	COG2132	Multicopper oxidase
TMO_0390	COG4774	siderophore transport
TMO_0393	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
TMO_0394	COG0583	DNA-binding transcription factor activity
TMO_0395	COG0583	DNA-binding transcription factor activity
TMO_0397	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
TMO_0400	COG0668	transmembrane transport
TMO_0401	COG0842	Transport permease protein
TMO_0404	COG0386	Belongs to the glutathione peroxidase family
TMO_0406	COG0123	including yeast histone deacetylase and acetoin utilization protein
TMO_0411	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
TMO_0412	COG0667	Aldo Keto reductase
TMO_0413	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
TMO_0414	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
TMO_0415	COG0583	DNA-binding transcription factor activity
TMO_0416	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
TMO_0417	COG3002	Belongs to the UPF0753 family
TMO_0419	COG1609	Transcriptional regulator
TMO_0420	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
TMO_0420	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
TMO_0421	COG1105	Belongs to the carbohydrate kinase PfkB family
TMO_0422	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
TMO_0422	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
TMO_0423	COG1335	isochorismatase
TMO_0424	COG4774	siderophore transport
TMO_0425	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
TMO_0426	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
TMO_0430	COG0243	molybdopterin cofactor binding
TMO_0431	COG1028	Short-chain dehydrogenase reductase Sdr
TMO_0433	COG3842	ATPase activity
TMO_0439	COG3047	cAMP biosynthetic process
TMO_0440	COG0635	Involved in the biosynthesis of porphyrin-containing compound
TMO_0444	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
TMO_0445	COG0457	Tetratricopeptide repeat
TMO_0448	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
TMO_0450	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
TMO_0451	COG2205	protein histidine kinase activity
TMO_0456	COG0583	DNA-binding transcription factor activity
TMO_0462	COG2186	Transcriptional regulator
TMO_0463	COG1304	FMN binding
TMO_0469	COG0745	RESPONSE REGULATOR receiver
TMO_0474	COG0318	PFAM AMP-dependent synthetase and ligase
TMO_0478	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
TMO_0483	COG1024	Enoyl-CoA hydratase
TMO_0485	COG1032	radical SAM domain protein
TMO_0490	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
TMO_0496	COG1129	ABC transporter
TMO_0503	COG3932	Exopolysaccharide synthesis, ExoD
TMO_0505	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
TMO_0508	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
TMO_0509	COG2202	Pas domain
TMO_0509	COG2205	protein histidine kinase activity
TMO_0510	COG1960	acyl-CoA dehydrogenase activity
TMO_0513	COG0318	PFAM AMP-dependent synthetase and ligase
TMO_0514	COG2814	Major facilitator Superfamily
TMO_0516	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
TMO_0517	COG0400	carboxylic ester hydrolase activity
TMO_0520	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
TMO_0521	COG1309	transcriptional regulator
TMO_0522	COG1960	acyl-CoA dehydrogenase activity
TMO_0524	COG3777	bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding
TMO_0525	COG0523	cobalamin synthesis protein
TMO_0529	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
TMO_0531	COG2124	cytochrome p450
TMO_0533	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
TMO_0537	COG0456	acetyltransferase
TMO_0538	COG0183	Belongs to the thiolase family
TMO_0540	COG0589	response to stress
TMO_0543	COG3485	protocatechuate 3,4-dioxygenase
TMO_0544	COG2207	Transcriptional regulator
TMO_0547	COG1454	alcohol dehydrogenase
TMO_0549	COG0824	Thioesterase
TMO_0550	COG2983	Belongs to the UPF0260 family
TMO_0551	COG0318	PFAM AMP-dependent synthetase and ligase
TMO_0554	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
TMO_0555	COG0022	dehydrogenase e1 component
TMO_0556	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
TMO_0557	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
TMO_0559	COG0028	Belongs to the TPP enzyme family
TMO_0561	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
TMO_0565	COG1525	nuclease
TMO_0566	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
TMO_0567	COG2166	iron-sulfur cluster assembly
TMO_0568	COG0235	Class ii aldolase
TMO_0570	COG0154	amidase activity
TMO_0573	COG3396	Phenylacetate-CoA oxygenase
TMO_0574	COG1192	Involved in chromosome partitioning
TMO_0577	COG1210	Utp--glucose-1-phosphate uridylyltransferase
TMO_0578	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
TMO_0580	COG0861	Integral membrane protein TerC family
TMO_0581	COG0840	transmembrane signaling receptor activity
TMO_0581	COG2203	Gaf domain
TMO_0582	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
TMO_0584	COG1686	Belongs to the peptidase S11 family
TMO_0595	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
TMO_0600	COG1028	Short-chain dehydrogenase reductase Sdr
TMO_0601	COG0501	Belongs to the peptidase M48B family
TMO_0603	COG0028	Belongs to the TPP enzyme family
TMO_0605	COG1012	belongs to the aldehyde dehydrogenase family
TMO_0606	COG1902	pentaerythritol trinitrate reductase activity
TMO_0611	COG2271	Major facilitator Superfamily
TMO_0615	COG4106	trans-aconitate 2-methyltransferase activity
TMO_0616	COG2814	Major facilitator Superfamily
TMO_0618	COG0840	transmembrane signaling receptor activity
TMO_0621	COG2906	2 iron, 2 sulfur cluster binding
TMO_0622	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
TMO_0628	COG1250	3-hydroxyacyl-CoA dehydrogenase
TMO_0629	COG1960	acyl-CoA dehydrogenase activity
TMO_0630	COG1960	acyl-CoA dehydrogenase activity
TMO_0631	COG1960	acyl-CoA dehydrogenase activity
TMO_0632	COG1250	3-hydroxyacyl-CoA dehydrogenase
TMO_0632	COG1024	Enoyl-CoA hydratase
TMO_0636	COG0559	Belongs to the binding-protein-dependent transport system permease family
TMO_0639	COG0318	PFAM AMP-dependent synthetase and ligase
TMO_0641	COG1028	Short-chain dehydrogenase reductase Sdr
TMO_0642	COG1028	Short-chain dehydrogenase reductase Sdr
TMO_0646	COG1960	acyl-CoA dehydrogenase activity
TMO_0648	COG3321	synthase
TMO_0648	COG1028	Short-chain dehydrogenase reductase Sdr
TMO_0648	COG0604	alcohol dehydrogenase
TMO_0649	COG0840	transmembrane signaling receptor activity
TMO_0654	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
TMO_0657	COG3186	Phenylalanine-4-hydroxylase
TMO_0662	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
TMO_0672	COG0402	S-adenosylhomocysteine deaminase activity
TMO_0678	COG0586	Pfam SNARE associated Golgi protein
TMO_0680	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
TMO_0680	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
TMO_0683	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
TMO_0687	COG2895	sulfate adenylyltransferase (ATP) activity
TMO_0688	COG0529	Catalyzes the synthesis of activated sulfate
TMO_0689	COG0318	PFAM AMP-dependent synthetase and ligase
TMO_0690	COG1028	Short-chain dehydrogenase reductase Sdr
TMO_0693	COG2030	dehydratase
TMO_0694	COG1804	L-carnitine dehydratase bile acid-inducible protein F
TMO_0695	COG1846	Transcriptional regulator
TMO_0696	COG1028	Short-chain dehydrogenase reductase Sdr
TMO_0697	COG1960	acyl-CoA dehydrogenase activity
TMO_0699	COG1024	Enoyl-CoA hydratase
TMO_0700	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
TMO_0703	COG4208	sulfate ABC transporter
TMO_0704	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
TMO_0712	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
TMO_0713	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
TMO_0719	COG3335	DDE superfamily endonuclease
TMO_0720	COG3415	Transposase
TMO_0724	COG2824	Alkylphosphonate utilization operon protein PhnA
TMO_0727	COG2311	Membrane
TMO_0729	COG1695	Transcriptional regulator
TMO_0731	COG2814	Major facilitator Superfamily
TMO_0732	COG0583	DNA-binding transcription factor activity
TMO_0734	COG5507	3-demethylubiquinone-9 3-methyltransferase
TMO_0737	COG1846	Transcriptional regulator
TMO_0738	COG0697	spore germination
TMO_0739	COG2130	NADP-dependent
TMO_0741	COG2423	ornithine cyclodeaminase activity
TMO_0743	COG1846	Transcriptional regulator
TMO_0745	COG1393	Belongs to the ArsC family
TMO_0746	COG2866	Carboxypeptidase
TMO_0748	COG0513	Belongs to the DEAD box helicase family
TMO_0749	COG0840	transmembrane signaling receptor activity
TMO_0754	COG0534	Mate efflux family protein
TMO_0760	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
TMO_0764	COG0768	penicillin binding
TMO_0765	COG0772	Belongs to the SEDS family
TMO_0768	COG0519	Catalyzes the synthesis of GMP from XMP
TMO_0769	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
TMO_0770	COG1309	transcriptional regulator
TMO_0780	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
TMO_0786	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
TMO_0787	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
TMO_0789	COG0415	Belongs to the DNA photolyase family
TMO_0790	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
TMO_0795	COG1028	Short-chain dehydrogenase reductase Sdr
TMO_0803	COG0411	ABC transporter
TMO_0804	COG0410	ABC transporter
TMO_0808	COG0582	viral genome integration into host DNA
TMO_0811	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
TMO_0814	COG5002	protein histidine kinase activity
TMO_0814	COG2176	DNA-directed DNA polymerase activity
TMO_0816	COG2267	carboxylic ester hydrolase activity
TMO_0820	COG0488	(ABC) transporter
TMO_0821	COG3309	Virulence-associated protein D
TMO_0823	COG2853	Lipoprotein
TMO_0826	COG1410	methionine synthase
TMO_0826	COG0646	methionine synthase
TMO_0827	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
TMO_0828	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
TMO_0829	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
TMO_0830	COG2175	clavaminate synthase activity
TMO_0833	COG0828	Belongs to the bacterial ribosomal protein bS21 family
TMO_0836	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
TMO_0837	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
TMO_0843	COG0163	prenyltransferase activity
TMO_0845	COG0318	PFAM AMP-dependent synthetase and ligase
TMO_0846	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
TMO_0848	COG2271	Major facilitator Superfamily
TMO_0852	COG3321	synthase
TMO_0852	COG0604	alcohol dehydrogenase
TMO_0852	COG1028	Short-chain dehydrogenase reductase Sdr
TMO_0856	COG1028	Short-chain dehydrogenase reductase Sdr
TMO_0859	COG1309	transcriptional regulator
TMO_0863	COG1744	ABC transporter substrate-binding protein PnrA-like
TMO_0868	COG2113	Glycine betaine
TMO_0869	COG4176	ABC-type proline glycine betaine transport system permease component
TMO_0874	COG0254	rRNA binding
TMO_0878	COG0483	inositol monophosphate 1-phosphatase activity
TMO_0879	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
TMO_0880	COG0352	thiamine-phosphate diphosphorylase activity
TMO_0881	COG1830	Aldolase
TMO_0883	COG0126	phosphoglycerate kinase activity
TMO_0887	COG1115	amino acid carrier protein
TMO_0888	COG1027	Aspartate ammonia-lyase
TMO_0889	COG0252	asparaginase activity
TMO_0894	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
TMO_0896	COG1692	metallophosphoesterase
TMO_0897	COG0217	transcriptional regulatory protein
TMO_0898	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
TMO_0899	COG0632	four-way junction helicase activity
TMO_0900	COG2255	four-way junction helicase activity
TMO_0901	COG0824	Thioesterase
TMO_0902	COG0154	amidase activity
TMO_0907	COG0823	Involved in the tonB-independent uptake of proteins
TMO_0910	COG0037	tRNA processing
TMO_0911	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
TMO_0913	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
TMO_0915	COG0351	phosphomethylpyrimidine kinase
TMO_0919	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
TMO_0920	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
TMO_0921	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
TMO_0925	COG1129	ABC transporter
TMO_0927	COG0559	Belongs to the binding-protein-dependent transport system permease family
TMO_0929	COG3800	Transcriptional regulator
TMO_0929	COG1396	sequence-specific DNA binding
TMO_0930	COG0745	RESPONSE REGULATOR receiver
TMO_0932	COG5002	protein histidine kinase activity
TMO_0934	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
TMO_0935	COG0564	pseudouridine synthase activity
TMO_0938	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
TMO_0940	COG0318	PFAM AMP-dependent synthetase and ligase
TMO_0943	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
TMO_0944	COG1396	sequence-specific DNA binding
TMO_0944	COG1917	Cupin 2, conserved barrel domain protein
TMO_0946	COG0686	Belongs to the AlaDH PNT family
TMO_0951	COG2363	Small membrane protein
TMO_0953	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
TMO_0956	COG1136	(ABC) transporter
TMO_0956	COG0577	efflux transmembrane transporter activity
TMO_0957	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
TMO_0958	COG2326	polyphosphate kinase activity
TMO_0960	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
TMO_0963	COG0123	including yeast histone deacetylase and acetoin utilization protein
TMO_0964	COG1722	exodeoxyribonuclease VII activity
TMO_0965	COG0142	geranyltranstransferase activity
TMO_0966	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
TMO_0967	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
TMO_0968	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
TMO_0971	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
TMO_0973	COG0318	PFAM AMP-dependent synthetase and ligase
TMO_0975	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
TMO_0976	COG2030	dehydratase
TMO_0979	COG1960	acyl-CoA dehydrogenase activity
TMO_0980	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
TMO_0983	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
TMO_0984	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
TMO_0985	COG1295	ribonuclease BN
TMO_0986	COG0484	heat shock protein binding
TMO_0989	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
TMO_0990	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
TMO_0991	COG2818	Glycosylase
TMO_0992	COG0354	folic acid binding
TMO_0994	COG0438	transferase activity, transferring glycosyl groups
TMO_0995	COG0438	transferase activity, transferring glycosyl groups
TMO_0996	COG0367	asparagine synthase
TMO_0997	COG5342	invasion associated locus B
TMO_0998	COG2205	protein histidine kinase activity
TMO_0998	COG2202	Pas domain
TMO_0999	COG0717	Belongs to the dCTP deaminase family
TMO_1002	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
TMO_1003	COG5328	Belongs to the UPF0262 family
TMO_1004	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
TMO_1007	COG1530	ribonuclease E activity
TMO_1008	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
TMO_1017	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
TMO_1018	COG0583	DNA-binding transcription factor activity
TMO_1021	COG3383	formate dehydrogenase (NAD+) activity
TMO_1022	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
TMO_1026	COG1012	belongs to the aldehyde dehydrogenase family
TMO_1027	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
TMO_1031	COG0601	transmembrane transport
TMO_1032	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
TMO_1033	COG0583	DNA-binding transcription factor activity
TMO_1043	COG0667	Aldo Keto reductase
TMO_1045	COG4774	siderophore transport
TMO_1047	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
TMO_1057	COG3220	belongs to the UPF0276 family
TMO_1062	COG0737	Belongs to the 5'-nucleotidase family
TMO_1066	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
TMO_1068	COG2205	protein histidine kinase activity
TMO_1068	COG2202	Pas domain
TMO_1069	COG1012	belongs to the aldehyde dehydrogenase family
TMO_1082	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
TMO_1083	COG1215	transferase activity, transferring glycosyl groups
TMO_1084	COG1215	transferase activity, transferring glycosyl groups
TMO_1086	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
TMO_1093	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
TMO_1094	COG2205	protein histidine kinase activity
TMO_1094	COG2202	Pas domain
TMO_1095	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
TMO_1097	COG4786	Flagellar basal body rod
TMO_1098	COG4786	Flagellar basal body rod
TMO_1103	COG0745	RESPONSE REGULATOR receiver
TMO_1108	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
TMO_1115	COG0583	DNA-binding transcription factor activity
TMO_1116	COG1338	Plays a role in the flagellum-specific transport system
TMO_1122	COG1558	bacterial-type flagellum-dependent cell motility
TMO_1123	COG1677	Flagellar hook-basal body complex protein FliE
TMO_1124	COG1987	bacterial-type flagellum assembly
TMO_1125	COG1684	flagellar biosynthetic protein fliR
TMO_1126	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
TMO_1130	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
TMO_1133	COG0456	acetyltransferase
TMO_1134	COG0523	cobalamin synthesis protein
TMO_1135	COG1250	3-hydroxyacyl-CoA dehydrogenase
TMO_1136	COG0538	isocitrate dehydrogenase activity
TMO_1139	COG2814	Major facilitator Superfamily
TMO_1142	COG1309	transcriptional regulator
TMO_1144	COG0625	glutathione transferase activity
TMO_1145	COG0625	glutathione transferase activity
TMO_1146	COG1172	Belongs to the binding-protein-dependent transport system permease family
TMO_1147	COG1129	ABC transporter
TMO_1148	COG1879	ABC-type sugar transport system periplasmic component
TMO_1149	COG1984	allophanate hydrolase subunit 2
TMO_1152	COG0511	ligase activity, forming carbon-carbon bonds
TMO_1153	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
TMO_1154	COG0583	DNA-binding transcription factor activity
TMO_1156	COG0693	protein deglycase activity
TMO_1158	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
TMO_1160	COG1349	DNA-binding transcription factor activity
TMO_1162	COG1733	regulation of RNA biosynthetic process
TMO_1163	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
TMO_1168	COG2226	methyltransferase
TMO_1169	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
TMO_1170	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
TMO_1177	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
TMO_1181	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
TMO_1183	COG4608	Belongs to the ABC transporter superfamily
TMO_1184	COG0444	Belongs to the ABC transporter superfamily
TMO_1185	COG0747	negative chemotaxis
TMO_1192	COG1335	isochorismatase
TMO_1199	COG0746	molybdenum cofactor guanylyltransferase activity
TMO_1200	COG2076	Multidrug Resistance protein
TMO_1206	COG0318	PFAM AMP-dependent synthetase and ligase
TMO_1208	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
TMO_1210	COG0308	aminopeptidase N
TMO_1215	COG1434	Gram-negative-bacterium-type cell wall biogenesis
TMO_1216	COG3706	GGDEF domain
TMO_1216	COG0745	RESPONSE REGULATOR receiver
TMO_1219	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
TMO_1223	COG0643	Histidine kinase
TMO_1223	COG2198	Histidine kinase
TMO_1225	COG2201	protein-glutamate methylesterase activity
TMO_1226	COG2201	protein-glutamate methylesterase activity
TMO_1227	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
TMO_1228	COG0745	RESPONSE REGULATOR receiver
TMO_1229	COG1157	protein secretion by the type III secretion system
TMO_1234	COG2271	Major facilitator Superfamily
TMO_1238	COG0455	bacterial-type flagellum organization
TMO_1240	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
TMO_1241	COG2204	response regulator
TMO_1242	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
TMO_1243	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
TMO_1245	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
TMO_1246	COG1766	The M ring may be actively involved in energy transduction
TMO_1248	COG1749	Flagellar hook protein flgE
TMO_1249	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
TMO_1251	COG2205	protein histidine kinase activity
TMO_1251	COG2202	Pas domain
TMO_1253	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
TMO_1254	COG2203	Gaf domain
TMO_1254	COG3706	GGDEF domain
TMO_1254	COG4251	negative regulation of phosphorylation
TMO_1254	COG5001	Diguanylate cyclase
TMO_1255	COG0583	DNA-binding transcription factor activity
TMO_1268	COG0641	radical SAM
TMO_1271	COG4336	lyase activity
TMO_1274	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
TMO_1278	COG1902	pentaerythritol trinitrate reductase activity
TMO_1282	COG0803	Belongs to the bacterial solute-binding protein 9 family
TMO_1285	COG1024	Enoyl-CoA hydratase
TMO_1286	COG0318	PFAM AMP-dependent synthetase and ligase
TMO_1287	COG4221	oxidoreductase activity
TMO_1291	COG1172	Belongs to the binding-protein-dependent transport system permease family
TMO_1293	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
TMO_1295	COG1070	Carbohydrate kinase
TMO_1296	COG1028	Short-chain dehydrogenase reductase Sdr
TMO_1302	COG4771	TonB-dependent receptor
TMO_1306	COG0697	spore germination
TMO_1317	COG0395	ABC-type sugar transport system, permease component
TMO_1318	COG1175	transmembrane transport
TMO_1319	COG1653	transport
TMO_1320	COG3842	ATPase activity
TMO_1323	COG1404	Belongs to the peptidase S8 family
TMO_1325	COG0523	cobalamin synthesis protein
TMO_1329	COG1522	sequence-specific DNA binding
TMO_1330	COG4771	TonB-dependent receptor
TMO_1333	COG4558	Periplasmic binding protein
TMO_1334	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
TMO_1335	COG1120	ATPase activity
TMO_1337	COG1970	mechanosensitive ion channel activity
TMO_1341	COG0811	peptide transport
TMO_1347	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
TMO_1350	COG1741	Belongs to the pirin family
TMO_1351	COG0006	proline dipeptidase activity
TMO_1357	COG1492	cobalamin metabolic process
TMO_1361	COG1643	Atp-dependent helicase
TMO_1363	COG0583	DNA-binding transcription factor activity
TMO_1364	COG0154	amidase activity
TMO_1370	COG0546	phosphoglycolate phosphatase activity
TMO_1372	COG1960	acyl-CoA dehydrogenase activity
TMO_1376	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
TMO_1379	COG1028	Short-chain dehydrogenase reductase Sdr
TMO_1381	COG0318	PFAM AMP-dependent synthetase and ligase
TMO_1385	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
TMO_1386	COG0735	belongs to the Fur family
TMO_1387	COG1121	(ABC) transporter
TMO_1388	COG1108	ABC-type Mn2 Zn2 transport systems permease components
TMO_1390	COG1176	ABC-type spermidine putrescine transport system, permease component I
TMO_1391	COG1176	ABC-type spermidine putrescine transport system, permease component I
TMO_1392	COG3842	ATPase activity
TMO_1401	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
TMO_1402	COG0318	PFAM AMP-dependent synthetase and ligase
TMO_1403	COG1250	3-hydroxyacyl-CoA dehydrogenase
TMO_1403	COG1024	Enoyl-CoA hydratase
TMO_1404	COG1802	Transcriptional regulator
TMO_1406	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
TMO_1407	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
TMO_1409	COG1024	Enoyl-CoA hydratase
TMO_1412	COG0154	amidase activity
TMO_1415	COG0656	L-ascorbic acid biosynthetic process
TMO_1418	COG0747	negative chemotaxis
TMO_1419	COG0601	transmembrane transport
TMO_1424	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
TMO_1424	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
TMO_1428	COG4647	ligase activity
TMO_1429	COG0146	N-methylhydantoinase B acetone carboxylase alpha subunit
TMO_1430	COG0145	ligase activity
TMO_1431	COG3284	Transcriptional regulator
TMO_1434	COG0318	PFAM AMP-dependent synthetase and ligase
TMO_1436	COG0248	Ppx GppA phosphatase
TMO_1437	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
TMO_1439	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
TMO_1439	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
TMO_1441	COG1285	pathogenesis
TMO_1443	COG2267	carboxylic ester hydrolase activity
TMO_1444	COG0697	spore germination
TMO_1445	COG0519	Catalyzes the synthesis of GMP from XMP
TMO_1447	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
TMO_1447	COG3320	Male sterility
TMO_1448	COG0667	Aldo Keto reductase
TMO_1449	COG0583	DNA-binding transcription factor activity
TMO_1455	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
TMO_1456	COG1881	PFAM PEBP family protein
TMO_1459	COG5441	Belongs to the UPF0261 family
TMO_1460	COG5564	TIM-barrel signal transduction protein
TMO_1470	COG0437	4 iron, 4 sulfur cluster binding
TMO_1478	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
TMO_1483	COG0730	response to heat
TMO_1484	COG0640	Transcriptional regulator
TMO_1485	COG0450	alkyl hydroperoxide reductase
TMO_1486	COG1522	sequence-specific DNA binding
TMO_1492	COG0604	alcohol dehydrogenase
TMO_1493	COG1309	transcriptional regulator
TMO_1498	COG3655	Transcriptional regulator
TMO_1499	COG0625	glutathione transferase activity
TMO_1506	COG0316	Belongs to the HesB IscA family
TMO_1507	COG0232	Belongs to the dGTPase family. Type 2 subfamily
TMO_1511	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
TMO_1512	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
TMO_1524	COG1305	Transglutaminase-like
TMO_1526	COG2308	Evidence 4 Homologs of previously reported genes of
TMO_1527	COG2172	sigma factor antagonist activity
TMO_1528	COG1366	Belongs to the anti-sigma-factor antagonist family
TMO_1530	COG1253	flavin adenine dinucleotide binding
TMO_1531	COG1253	flavin adenine dinucleotide binding
TMO_1533	COG1840	ABC-type Fe3 transport system, periplasmic component
TMO_1534	COG1178	ABC-type Fe3 transport system permease component
TMO_1535	COG3842	ATPase activity
TMO_1536	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
TMO_1537	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
TMO_1538	COG0805	protein transport
TMO_1541	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
TMO_1542	COG4942	peptidase
TMO_1543	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
TMO_1547	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
TMO_1550	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
TMO_1551	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
TMO_1552	COG1562	ergosterol biosynthetic process
TMO_1554	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
TMO_1556	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
TMO_1557	COG0840	transmembrane signaling receptor activity
TMO_1559	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
TMO_1561	COG4208	sulfate ABC transporter
TMO_1566	COG0629	single-stranded DNA binding
TMO_1568	COG1846	Transcriptional regulator
TMO_1569	COG1764	response to oxidative stress
TMO_1571	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
TMO_1572	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
TMO_1573	COG0343	queuine tRNA-ribosyltransferase activity
TMO_1574	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
TMO_1578	COG1012	belongs to the aldehyde dehydrogenase family
TMO_1579	COG3622	Belongs to the hyi family
TMO_1583	COG0741	lytic transglycosylase activity
TMO_1584	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
TMO_1585	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
TMO_1586	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
TMO_1587	COG1573	uracil-dna glycosylase
TMO_1590	COG1758	RNA polymerase activity
TMO_1592	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
TMO_1593	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
TMO_1594	COG0736	holo-[acyl-carrier-protein] synthase activity
TMO_1595	COG0681	Belongs to the peptidase S26 family
TMO_1597	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
TMO_1602	COG0583	DNA-binding transcription factor activity
TMO_1603	COG1381	Involved in DNA repair and RecF pathway recombination
TMO_1604	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
TMO_1605	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
TMO_1608	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
TMO_1609	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
TMO_1610	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
TMO_1612	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
TMO_1616	COG0113	porphobilinogen synthase activity
TMO_1617	COG1024	Enoyl-CoA hydratase
TMO_1618	COG1846	Transcriptional regulator
TMO_1619	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
TMO_1620	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
TMO_1621	COG0596	Alpha beta hydrolase
TMO_1624	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
TMO_1625	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
TMO_1627	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
TMO_1630	COG0745	RESPONSE REGULATOR receiver
TMO_1633	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
TMO_1634	COG0840	transmembrane signaling receptor activity
TMO_1636	COG0438	transferase activity, transferring glycosyl groups
TMO_1638	COG1278	Cold shock
TMO_1639	COG1278	Cold shock
TMO_1643	COG0410	ABC transporter
TMO_1646	COG0559	Belongs to the binding-protein-dependent transport system permease family
TMO_1648	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
TMO_1653	COG0356	it plays a direct role in the translocation of protons across the membrane
TMO_1655	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
TMO_1655	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
TMO_1656	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
TMO_1662	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
TMO_1662	COG0574	Belongs to the PEP-utilizing enzyme family
TMO_1663	COG1174	glycine betaine transport
TMO_1664	COG1125	glycine betaine transport
TMO_1665	COG1174	glycine betaine transport
TMO_1666	COG1732	Glycine betaine
TMO_1668	COG3706	GGDEF domain
TMO_1672	COG3328	transposase activity
TMO_1674	COG2951	lytic endotransglycosylase activity
TMO_1676	COG1686	Belongs to the peptidase S11 family
TMO_1677	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
TMO_1679	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
TMO_1680	COG0084	hydrolase, TatD family'
TMO_1681	COG0321	lipoyl(octanoyl) transferase activity
TMO_1681	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
TMO_1684	COG2814	Major facilitator Superfamily
TMO_1688	COG0670	Belongs to the BI1 family
TMO_1692	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
TMO_1693	COG3956	TIGRFAM MazG family protein
TMO_1694	COG4221	oxidoreductase activity
TMO_1695	COG4221	oxidoreductase activity
TMO_1696	COG0459	protein refolding
TMO_1697	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
TMO_1698	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
TMO_1699	COG1923	regulation of RNA biosynthetic process
TMO_1701	COG0569	domain protein
TMO_1702	COG2204	response regulator
TMO_1707	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
TMO_1707	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
TMO_1708	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
TMO_1709	COG1058	Belongs to the CinA family
TMO_1709	COG1546	Belongs to the CinA family
TMO_1710	COG1595	DNA-templated transcription, initiation
TMO_1713	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
TMO_1714	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
TMO_1715	COG0508	dehydrogenase complex catalyzes the overall conversion of
TMO_1716	COG0022	dehydrogenase e1 component
TMO_1716	COG0508	dehydrogenase complex catalyzes the overall conversion of
TMO_1717	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
TMO_1718	COG0583	DNA-binding transcription factor activity
TMO_1719	COG1024	Enoyl-CoA hydratase
TMO_1721	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
TMO_1727	COG0829	nickel cation binding
TMO_1728	COG0831	urea catabolic process
TMO_1729	COG0832	Belongs to the urease beta subunit family
TMO_1730	COG0804	urea catabolic process
TMO_1731	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
TMO_1732	COG0830	nickel cation binding
TMO_1733	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
TMO_1744	COG0583	DNA-binding transcription factor activity
TMO_1746	COG0148	phosphopyruvate hydratase activity
TMO_1747	COG2877	3-deoxy-8-phosphooctulonate synthase activity
TMO_1748	COG0504	CTP synthase activity
TMO_1750	COG0149	triose-phosphate isomerase activity
TMO_1752	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
TMO_1755	COG2861	carbohydrate metabolic process
TMO_1757	COG2217	Heavy metal translocating P-type atpase
TMO_1762	COG0303	'Molybdopterin
TMO_1768	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
TMO_1769	COG3494	Protein of unknown function (DUF1009)
TMO_1770	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
TMO_1771	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
TMO_1772	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
TMO_1774	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
TMO_1775	COG0750	zinc metalloprotease
TMO_1776	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
TMO_1777	COG0575	Belongs to the CDS family
TMO_1780	COG0528	UMP kinase activity
TMO_1781	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
TMO_1782	COG0052	Belongs to the universal ribosomal protein uS2 family
TMO_1783	COG0587	DNA-directed DNA polymerase activity
TMO_1789	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
TMO_1791	COG1024	Enoyl-CoA hydratase
TMO_1792	COG1832	CoA-binding protein
TMO_1793	COG2873	o-acetylhomoserine
TMO_1798	COG0583	DNA-binding transcription factor activity
TMO_1799	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
TMO_1804	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
TMO_1806	COG1078	dGTPase activity
TMO_1807	COG1324	tolerance protein
TMO_1809	COG0776	regulation of translation
TMO_1810	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
TMO_1811	COG0416	fatty acid biosynthetic process
TMO_1818	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
TMO_1820	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
TMO_1823	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
TMO_1823	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
TMO_1825	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
TMO_1826	COG0698	ribose 5-phosphate isomerase
TMO_1827	COG4957	zinc ion binding
TMO_1834	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
TMO_1837	COG0628	permease
TMO_1840	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
TMO_1841	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
TMO_1842	COG0105	UTP biosynthetic process
TMO_1843	COG0488	(ABC) transporter
TMO_1846	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
TMO_1849	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
TMO_1850	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
TMO_1851	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
TMO_1852	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
TMO_1854	COG0194	GDP metabolic process
TMO_1855	COG1561	YicC-like family, N-terminal region
TMO_1857	COG4206	TonB-dependent receptor
TMO_1859	COG4139	cobalamin transport
TMO_1860	COG1120	ATPase activity
TMO_1862	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
TMO_1863	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
TMO_1864	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
TMO_1866	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
TMO_1868	COG0360	Binds together with S18 to 16S ribosomal RNA
TMO_1869	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
TMO_1872	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
TMO_1873	COG0305	Participates in initiation and elongation during chromosome replication
TMO_1874	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
TMO_1875	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
TMO_1876	COG1127	ABC transporter
TMO_1878	COG1286	toxin biosynthetic process
TMO_1879	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
TMO_1880	COG1028	Short-chain dehydrogenase reductase Sdr
TMO_1884	COG1160	GTP binding
TMO_1888	COG1752	Esterase of the alpha-beta hydrolase superfamily
TMO_1894	COG3145	DNA-N1-methyladenine dioxygenase activity
TMO_1900	COG4993	Dehydrogenase
TMO_1902	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
TMO_1908	COG0525	valine-tRNA ligase activity
TMO_1911	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
TMO_1917	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
TMO_1924	COG2205	protein histidine kinase activity
TMO_1924	COG2202	Pas domain
TMO_1924	COG2202	Pas domain
TMO_1924	COG2205	protein histidine kinase activity
TMO_1925	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
TMO_1927	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
TMO_1928	COG0587	DNA-directed DNA polymerase activity
TMO_1929	COG3963	phosphatidate phosphatase activity
TMO_1930	COG2205	protein histidine kinase activity
TMO_1930	COG2202	Pas domain
TMO_1931	COG2719	SpoVR family
TMO_1933	COG2766	serine protein kinase
TMO_1939	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
TMO_1940	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
TMO_1941	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
TMO_1942	COG1494	fructose-1,6-bisphosphatase
TMO_1944	COG0436	Aminotransferase
TMO_1945	COG3243	poly(R)-hydroxyalkanoic acid synthase
TMO_1947	COG2814	Major facilitator Superfamily
TMO_1948	COG2855	membrane
TMO_1950	COG1136	(ABC) transporter
TMO_1951	COG4591	ABC-type transport system involved in lipoprotein release permease component
TMO_1952	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
TMO_1954	COG2252	PERMEase
TMO_1958	COG0583	DNA-binding transcription factor activity
TMO_1959	COG1280	lysine exporter protein (LysE YggA)
TMO_1964	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
TMO_1964	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
TMO_1965	COG1007	ATP synthesis coupled electron transport
TMO_1968	COG0713	ATP synthesis coupled electron transport
TMO_1970	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
TMO_1971	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
TMO_1972	COG1034	ATP synthesis coupled electron transport
TMO_1975	COG0649	NAD binding
TMO_1976	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
TMO_1977	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
TMO_1978	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
TMO_1979	COG2072	flavoprotein involved in K transport
TMO_1980	COG0776	regulation of translation
TMO_1983	COG0740	serine-type endopeptidase activity
TMO_1986	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
TMO_1988	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
TMO_1988	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
TMO_1991	COG0436	Aminotransferase
TMO_1993	COG0174	glutamine synthetase
TMO_1995	COG0583	DNA-binding transcription factor activity
TMO_1996	COG0187	DNA topoisomerase II activity
TMO_2001	COG0840	transmembrane signaling receptor activity
TMO_2003	COG3454	Phosphonate metabolism
TMO_2006	COG0513	Belongs to the DEAD box helicase family
TMO_2007	COG2945	thiolester hydrolase activity
TMO_2007	COG0596	Alpha beta hydrolase
TMO_2014	COG2819	hydrolase of the alpha beta superfamily
TMO_2016	COG1017	nitric oxide dioxygenase activity
TMO_2016	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
TMO_2025	COG0747	negative chemotaxis
TMO_2026	COG0601	transmembrane transport
TMO_2027	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
TMO_2028	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
TMO_2029	COG1968	undecaprenyl-diphosphatase activity
TMO_2030	COG1024	Enoyl-CoA hydratase
TMO_2032	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
TMO_2033	COG1024	Enoyl-CoA hydratase
TMO_2037	COG2814	Major facilitator Superfamily
TMO_2038	COG2207	Transcriptional regulator
TMO_2039	COG1522	sequence-specific DNA binding
TMO_2040	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
TMO_2047	COG0411	ABC transporter
TMO_2051	COG0156	8-amino-7-oxononanoate synthase activity
TMO_2056	COG2992	FlgJ-related protein
TMO_2058	COG2205	protein histidine kinase activity
TMO_2059	COG0745	RESPONSE REGULATOR receiver
TMO_2063	COG1201	RNA secondary structure unwinding
TMO_2065	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
TMO_2065	COG1793	dna ligase
TMO_2066	COG1752	Esterase of the alpha-beta hydrolase superfamily
TMO_2068	COG2211	Major facilitator Superfamily
TMO_2072	COG4771	TonB-dependent receptor
TMO_2075	COG3380	Catalyzes the oxidation of the 1,2-dihydro- and 1,6- dihydro- isomeric forms of beta-NAD(P) back to beta-NAD(P) . May serve to protect primary metabolism dehydrogenases from inhibition by the 1,2-dihydro- and 1,6-dihydro-beta-NAD(P) isomers
TMO_2078	COG0729	surface antigen
TMO_2081	COG2271	Major facilitator Superfamily
TMO_2084	COG0183	Belongs to the thiolase family
TMO_2085	COG1250	3-hydroxyacyl-CoA dehydrogenase
TMO_2089	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
TMO_2090	COG3639	organic phosphonate transmembrane transporter activity
TMO_2091	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
TMO_2093	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
TMO_2095	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
TMO_2095	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
TMO_2096	COG3454	Phosphonate metabolism
TMO_2097	COG4778	phosphonate C-P lyase system protein PhnL
TMO_2098	COG4107	phosphonate C-P lyase system protein PhnK
TMO_2099	COG3627	carbon phosphorus lyase activity
TMO_2100	COG3626	phosphonate metabolism
TMO_2101	COG3625	alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity
TMO_2102	COG3624	Phosphonate C-P lyase system protein PhnG
TMO_2103	COG1609	Transcriptional regulator
TMO_2104	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
TMO_2108	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
TMO_2109	COG0514	ATP-dependent DNA helicase (RecQ)
TMO_2111	COG0697	spore germination
TMO_2113	COG1376	ErfK ybiS ycfS ynhG family protein
TMO_2115	COG0384	phenazine biosynthesis protein PhzF
TMO_2117	COG1765	OsmC-like protein
TMO_2118	COG2814	Major facilitator Superfamily
TMO_2119	COG1752	Esterase of the alpha-beta hydrolase superfamily
TMO_2120	COG2264	protein methyltransferase activity
TMO_2121	COG0484	heat shock protein binding
TMO_2123	COG0490	domain, Protein
TMO_2123	COG0471	metal ion transport
TMO_2124	COG0625	glutathione transferase activity
TMO_2125	COG2366	antibiotic biosynthetic process
TMO_2129	COG1802	Transcriptional regulator
TMO_2131	COG0179	Fumarylacetoacetate (FAA) hydrolase
TMO_2135	COG0559	Belongs to the binding-protein-dependent transport system permease family
TMO_2136	COG4214	carbohydrate transport
TMO_2137	COG0840	transmembrane signaling receptor activity
TMO_2139	COG1659	Linocin_M18 bacteriocin protein
TMO_2143	COG3135	benzoate transporter
TMO_2144	COG1763	Mo-molybdopterin cofactor biosynthetic process
TMO_2145	COG1116	anion transmembrane transporter activity
TMO_2145	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
TMO_2147	COG1116	anion transmembrane transporter activity
TMO_2148	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
TMO_2149	COG2146	nitrite reductase [NAD(P)H] activity
TMO_2150	COG0243	molybdopterin cofactor binding
TMO_2152	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
TMO_2152	COG1648	precorrin-2 dehydrogenase activity
TMO_2153	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
TMO_2154	COG2198	Histidine kinase
TMO_2154	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
TMO_2154	COG2205	protein histidine kinase activity
TMO_2154	COG0784	Response regulator, receiver
TMO_2156	COG0786	glutamate:sodium symporter activity
TMO_2157	COG0842	Transport permease protein
TMO_2158	COG0842	Transport permease protein
TMO_2158	COG1129	ABC transporter
TMO_2159	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
TMO_2166	COG1546	Belongs to the CinA family
TMO_2166	COG1058	Belongs to the CinA family
TMO_2168	COG1489	DNA binding
TMO_2169	COG0024	Methionine aminopeptidase
TMO_2170	COG2003	Belongs to the UPF0758 family
TMO_2178	COG0678	peroxiredoxin activity
TMO_2178	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
TMO_2180	COG1917	Cupin 2, conserved barrel domain protein
TMO_2180	COG2207	Transcriptional regulator
TMO_2181	COG1309	transcriptional regulator
TMO_2182	COG1733	regulation of RNA biosynthetic process
TMO_2190	COG3846	protein secretion by the type IV secretion system
TMO_2192	COG3451	type IV secretory pathway VirB4
TMO_2195	COG4962	Type ii secretion system protein e
TMO_2200	COG0681	Belongs to the peptidase S26 family
TMO_2203	COG1192	Involved in chromosome partitioning
TMO_2208	COG1476	TRANSCRIPTIONal
TMO_2210	COG5489	Protein of unknown function (DUF736)
TMO_2211	COG0587	DNA-directed DNA polymerase activity
TMO_2212	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
TMO_2213	COG4544	Component of the SOS system and an inhibitor of cell division. Accumulation of SulA causes rapid cessation of cell division and the appearance of long, non-septate filaments. In the presence of GTP, binds a polymerization-competent form of FtsZ in a 1 1 ratio, thus inhibiting FtsZ polymerization and therefore preventing it from participating in the assembly of the Z ring. This mechanism prevents the premature segregation of damaged DNA to daughter cells during cell division
TMO_2235	COG2132	Multicopper oxidase
TMO_2241	COG0789	Transcriptional regulator
TMO_2242	COG2814	Major facilitator Superfamily
TMO_2247	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
TMO_2248	COG0583	DNA-binding transcription factor activity
TMO_2250	COG2003	Belongs to the UPF0758 family
TMO_2251	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
TMO_2252	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
TMO_2256	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
TMO_2257	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
TMO_2258	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
TMO_2259	COG0047	phosphoribosylformylglycinamidine synthase activity
TMO_2260	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
TMO_2261	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
TMO_2262	COG0271	Belongs to the BolA IbaG family
TMO_2263	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
TMO_2267	COG4774	siderophore transport
TMO_2271	COG0402	S-adenosylhomocysteine deaminase activity
TMO_2274	COG0583	DNA-binding transcription factor activity
TMO_2287	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
TMO_2288	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
TMO_2289	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
TMO_2291	COG4771	TonB-dependent receptor
TMO_2293	COG1335	isochorismatase
TMO_2294	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
TMO_2298	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
TMO_2301	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
TMO_2306	COG0179	Fumarylacetoacetate (FAA) hydrolase
TMO_2308	COG1228	amidohydrolase
TMO_2309	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
TMO_2330	COG3263	regulation of cellular component size
TMO_2336	COG0175	sulfate reduction
TMO_2337	COG1218	3'(2'),5'-bisphosphate nucleotidase
TMO_2338	COG2137	regulation of response to DNA damage stimulus
TMO_2339	COG1192	Involved in chromosome partitioning
TMO_2341	COG0009	L-threonylcarbamoyladenylate synthase
TMO_2342	COG2205	protein histidine kinase activity
TMO_2342	COG2202	Pas domain
TMO_2344	COG0277	FAD linked oxidase domain protein
TMO_2346	COG2986	histidine ammonia-lyase
TMO_2347	COG0402	S-adenosylhomocysteine deaminase activity
TMO_2348	COG1228	amidohydrolase
TMO_2351	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
TMO_2354	COG1280	lysine exporter protein (LysE YggA)
TMO_2356	COG0840	transmembrane signaling receptor activity
TMO_2357	COG2205	protein histidine kinase activity
TMO_2359	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
TMO_2364	COG1309	transcriptional regulator
TMO_2383	COG4373	Mu-like prophage FluMu protein gp28
TMO_2408	COG0183	Belongs to the thiolase family
TMO_2409	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
TMO_2410	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
TMO_2410	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
TMO_2411	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
TMO_2412	COG3800	Transcriptional regulator
TMO_2412	COG1396	sequence-specific DNA binding
TMO_2415	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
TMO_2416	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
TMO_2417	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
TMO_2417	COG2755	lipolytic protein G-D-S-L family
TMO_2422	COG1024	Enoyl-CoA hydratase
TMO_2424	COG1764	response to oxidative stress
TMO_2427	COG0640	Transcriptional regulator
TMO_2430	COG0025	NhaP-type Na H and K H
TMO_2433	COG3485	protocatechuate 3,4-dioxygenase
TMO_2434	COG3485	protocatechuate 3,4-dioxygenase
TMO_2435	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
TMO_2436	COG0583	DNA-binding transcription factor activity
TMO_2439	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
TMO_2442	COG0517	IMP dehydrogenase activity
TMO_2445	COG1522	sequence-specific DNA binding
TMO_2448	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
TMO_2456	COG0583	DNA-binding transcription factor activity
TMO_2463	COG0667	Aldo Keto reductase
TMO_2471	COG1116	anion transmembrane transporter activity
TMO_2472	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
TMO_2473	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
TMO_2479	COG1006	Multisubunit Na H antiporter MnhC subunit
TMO_2480	COG0651	ATP synthesis coupled electron transport
TMO_2481	COG0651	ATP synthesis coupled electron transport
TMO_2483	COG0651	ATP synthesis coupled electron transport
TMO_2488	COG1028	Short-chain dehydrogenase reductase Sdr
TMO_2490	COG2207	Transcriptional regulator
TMO_2494	COG0840	transmembrane signaling receptor activity
TMO_2496	COG0501	Belongs to the peptidase M48B family
TMO_2498	COG0450	alkyl hydroperoxide reductase
TMO_2499	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
TMO_2500	COG0367	asparagine synthase
TMO_2501	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
TMO_2501	COG0189	ligase activity
TMO_2502	COG1363	Peptidase, m42
TMO_2504	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
TMO_2506	COG2897	thiosulfate sulfurtransferase activity
TMO_2511	COG1126	abc transporter atp-binding protein
TMO_2512	COG0765	amino acid transport
TMO_2513	COG4597	amino acid ABC transporter
TMO_2514	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
TMO_2515	COG0626	cystathionine gamma-synthase activity
TMO_2518	COG2204	response regulator
TMO_2523	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
TMO_2529	COG1024	Enoyl-CoA hydratase
TMO_2530	COG1024	Enoyl-CoA hydratase
TMO_2531	COG1804	L-carnitine dehydratase bile acid-inducible protein F
TMO_2532	COG1804	L-carnitine dehydratase bile acid-inducible protein F
TMO_2533	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
TMO_2534	COG3842	ATPase activity
TMO_2535	COG1176	ABC-type spermidine putrescine transport system, permease component I
TMO_2536	COG1177	transmembrane transport
TMO_2537	COG1012	belongs to the aldehyde dehydrogenase family
TMO_2539	COG0300	oxidoreductase activity
TMO_2540	COG0438	transferase activity, transferring glycosyl groups
TMO_2541	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
TMO_2542	COG1115	amino acid carrier protein
TMO_2544	COG1131	(ABC) transporter
TMO_2545	COG0842	Transport permease protein
TMO_2546	COG0540	Belongs to the ATCase OTCase family
TMO_2547	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
TMO_2548	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
TMO_2549	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
TMO_2551	COG0758	DNA mediated transformation
TMO_2552	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
TMO_2553	COG0557	exoribonuclease II activity
TMO_2555	COG2814	Major facilitator Superfamily
TMO_2558	COG0267	Belongs to the bacterial ribosomal protein bL33 family
TMO_2559	COG3706	GGDEF domain
TMO_2559	COG0745	RESPONSE REGULATOR receiver
TMO_2560	COG0784	Response regulator, receiver
TMO_2561	COG1940	carbohydrate kinase activity
TMO_2562	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
TMO_2566	COG2067	long-chain fatty acid transport protein
TMO_2568	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
TMO_2574	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
TMO_2575	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
TMO_2577	COG1960	acyl-CoA dehydrogenase activity
TMO_2578	COG0183	Belongs to the thiolase family
TMO_2579	COG1960	acyl-CoA dehydrogenase activity
TMO_2581	COG0583	DNA-binding transcription factor activity
TMO_2585	COG2814	Major facilitator Superfamily
TMO_2586	COG1595	DNA-templated transcription, initiation
TMO_2590	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
TMO_2591	COG2239	Acts as a magnesium transporter
TMO_2592	COG0280	phosphate acetyltransferase
TMO_2592	COG0281	malic enzyme
TMO_2593	COG0321	lipoyl(octanoyl) transferase activity
TMO_2594	COG1268	BioY protein
TMO_2596	COG1254	Belongs to the acylphosphatase family
TMO_2597	COG0277	FAD linked oxidase domain protein
TMO_2600	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
TMO_2602	COG0546	phosphoglycolate phosphatase activity
TMO_2603	COG0564	pseudouridine synthase activity
TMO_2604	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
TMO_2605	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
TMO_2606	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
TMO_2607	COG0203	ribosomal protein L17
TMO_2609	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
TMO_2610	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
TMO_2611	COG0563	adenylate kinase activity
TMO_2612	COG0201	protein transport
TMO_2613	COG0200	Binds to the 23S rRNA
TMO_2614	COG1841	ribosomal large subunit assembly
TMO_2615	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
TMO_2617	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
TMO_2618	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
TMO_2619	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
TMO_2620	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
TMO_2621	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
TMO_2623	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
TMO_2624	COG0255	Belongs to the universal ribosomal protein uL29 family
TMO_2625	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
TMO_2626	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
TMO_2627	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
TMO_2628	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
TMO_2631	COG0088	Forms part of the polypeptide exit tunnel
TMO_2634	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
TMO_2636	COG0049	tRNA binding
TMO_2637	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
TMO_2638	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
TMO_2639	COG0085	RNA polymerase activity
TMO_2641	COG0222	ribosome binding
TMO_2642	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
TMO_2643	COG0081	regulation of translation
TMO_2644	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
TMO_2646	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
TMO_2647	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
TMO_2648	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
TMO_2650	COG0745	RESPONSE REGULATOR receiver
TMO_2653	COG5265	(ABC) transporter
TMO_2657	COG0415	Belongs to the DNA photolyase family
TMO_2658	COG0493	'glutamate synthase
TMO_2658	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
TMO_2660	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
TMO_2661	COG4221	oxidoreductase activity
TMO_2663	COG3046	protein related to deoxyribodipyrimidine photolyase
TMO_2664	COG1028	Short-chain dehydrogenase reductase Sdr
TMO_2670	COG1537	nuclear-transcribed mRNA catabolic process, no-go decay
TMO_2671	COG1431	PFAM Stem cell self-renewal protein Piwi
TMO_2676	COG0848	biopolymer transport protein
TMO_2678	COG0521	Mo-molybdopterin cofactor biosynthetic process
TMO_2680	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
TMO_2682	COG0463	Glycosyl transferase, family 2
TMO_2683	COG0642	Histidine kinase
TMO_2684	COG0745	RESPONSE REGULATOR receiver
TMO_2685	COG2816	NAD+ diphosphatase activity
TMO_2687	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
TMO_2691	COG0783	Belongs to the Dps family
TMO_2693	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
TMO_2697	COG1322	Protein conserved in bacteria
TMO_2698	COG0242	peptide deformylase activity
TMO_2699	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
TMO_2703	COG1595	DNA-templated transcription, initiation
TMO_2705	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
TMO_2706	COG2171	N-acyltransferase activity
TMO_2708	COG5001	Diguanylate cyclase
TMO_2708	COG5002	protein histidine kinase activity
TMO_2709	COG0840	transmembrane signaling receptor activity
TMO_2710	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
TMO_2711	COG0218	Necessary for normal cell division and for the maintenance of normal septation
TMO_2712	COG0706	membrane insertase activity
TMO_2713	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
TMO_2715	COG0230	Belongs to the bacterial ribosomal protein bL34 family
TMO_2718	COG0398	Pfam SNARE associated Golgi protein
TMO_2720	COG2205	protein histidine kinase activity
TMO_2723	COG4172	Belongs to the ABC transporter superfamily
TMO_2724	COG0747	negative chemotaxis
TMO_2725	COG0601	transmembrane transport
TMO_2728	COG1116	anion transmembrane transporter activity
TMO_2729	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
TMO_2730	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
TMO_2733	COG0583	DNA-binding transcription factor activity
TMO_2734	COG0803	Belongs to the bacterial solute-binding protein 9 family
TMO_2735	COG1121	(ABC) transporter
TMO_2736	COG1108	ABC-type Mn2 Zn2 transport systems permease components
TMO_2737	COG1108	ABC-type Mn2 Zn2 transport systems permease components
TMO_2738	COG2197	response regulator
TMO_2739	COG2205	protein histidine kinase activity
TMO_2743	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
TMO_2747	COG2189	Belongs to the N(4) N(6)-methyltransferase family
TMO_2750	COG0583	DNA-binding transcription factor activity
TMO_2753	COG3795	YCII-related domain
TMO_2754	COG4941	Belongs to the sigma-70 factor family
TMO_2756	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
TMO_2756	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
TMO_2762	COG3411	Ferredoxin
TMO_2764	COG2346	COG2346, Truncated hemoglobins
TMO_2767	COG1797	cobyrinic acid a,c-diamide synthase activity
TMO_2769	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
TMO_2770	COG2099	Precorrin-6x reductase
TMO_2772	COG2875	Belongs to the precorrin methyltransferase family
TMO_2779	COG0356	it plays a direct role in the translocation of protons across the membrane
TMO_2780	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
TMO_2781	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
TMO_2782	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
TMO_2783	COG2208	phosphoserine phosphatase activity
TMO_2783	COG2770	Histidine kinase
TMO_2787	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
TMO_2788	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
TMO_2789	COG0509	glycine decarboxylation via glycine cleavage system
TMO_2790	COG0404	The glycine cleavage system catalyzes the degradation of glycine
TMO_2793	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
TMO_2794	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
TMO_2795	COG0328	RNA-DNA hybrid ribonuclease activity
TMO_2796	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
TMO_2797	COG0678	peroxiredoxin activity
TMO_2798	COG4232	protein-disulfide reductase activity
TMO_2799	COG1678	Uncharacterized ACR, COG1678
TMO_2801	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
TMO_2802	COG0425	Belongs to the sulfur carrier protein TusA family
TMO_2803	COG0612	Peptidase, M16
TMO_2805	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
TMO_2806	COG1612	heme a metabolic process
TMO_2810	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
TMO_2812	COG0109	protoheme IX farnesyltransferase activity
TMO_2814	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
TMO_2815	COG0312	modulator of DNA gyrase
TMO_2818	COG3246	L-lysine catabolic process to acetate
TMO_2820	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
TMO_2822	COG1385	rRNA (uridine-N3-)-methyltransferase activity
TMO_2823	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
TMO_2825	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
TMO_2829	COG0312	modulator of DNA gyrase
TMO_2830	COG0483	inositol monophosphate 1-phosphatase activity
TMO_2831	COG1132	(ABC) transporter
TMO_2833	COG1519	Transferase
TMO_2834	COG1663	tetraacyldisaccharide 4'-kinase activity
TMO_2838	COG0154	amidase activity
TMO_2839	COG1028	Short-chain dehydrogenase reductase Sdr
TMO_2840	COG1028	Short-chain dehydrogenase reductase Sdr
TMO_2842	COG4149	molybdate abc transporter
TMO_2843	COG1176	ABC-type spermidine putrescine transport system, permease component I
TMO_2844	COG3842	ATPase activity
TMO_2846	COG1846	Transcriptional regulator
TMO_2847	COG0747	negative chemotaxis
TMO_2849	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
TMO_2850	COG4172	Belongs to the ABC transporter superfamily
TMO_2851	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
TMO_2859	COG3246	L-lysine catabolic process to acetate
TMO_2860	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
TMO_2866	COG0583	DNA-binding transcription factor activity
TMO_2869	COG1917	Cupin 2, conserved barrel domain protein
TMO_2869	COG2169	Transcriptional regulator
TMO_2873	COG1570	exodeoxyribonuclease VII activity
TMO_2874	COG0151	Belongs to the GarS family
TMO_2875	COG1360	Flagellar Motor Protein
TMO_2877	COG0590	tRNA wobble adenosine to inosine editing
TMO_2878	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
TMO_2879	COG1187	pseudouridine synthase activity
TMO_2886	COG0166	Belongs to the GPI family
TMO_2887	COG0612	Peptidase, M16
TMO_2888	COG0612	Peptidase, M16
TMO_2891	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
TMO_2892	COG0196	riboflavin kinase activity
TMO_2893	COG2030	dehydratase
TMO_2894	COG0596	Alpha beta hydrolase
TMO_2896	COG2431	L-lysine efflux transmembrane transporter activity
TMO_2906	COG3842	ATPase activity
TMO_2907	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
TMO_2909	COG0024	Methionine aminopeptidase
TMO_2911	COG0840	transmembrane signaling receptor activity
TMO_2915	COG4303	Ethanolamine ammonia lyase large subunit
TMO_2917	COG3214	Protein conserved in bacteria
TMO_2918	COG3386	PFAM SMP-30 Gluconolaconase
TMO_2920	COG1120	ATPase activity
TMO_2921	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
TMO_2924	COG4771	TonB-dependent receptor
TMO_2925	COG0583	DNA-binding transcription factor activity
TMO_2927	COG4585	Histidine kinase
TMO_2933	COG3284	Transcriptional regulator
TMO_2934	COG1122	ATPase activity
TMO_2935	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
TMO_2937	COG1930	Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import
TMO_2938	COG0310	cobalt ion transport
TMO_2939	COG3795	YCII-related domain
TMO_2943	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
TMO_2947	COG4335	DNA alkylation repair
TMO_2949	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
TMO_2950	COG2986	histidine ammonia-lyase
TMO_2951	COG4175	Glycine betaine
TMO_2951	COG0517	IMP dehydrogenase activity
TMO_2952	COG4176	ABC-type proline glycine betaine transport system permease component
TMO_2956	COG1522	sequence-specific DNA binding
TMO_2962	COG3609	addiction module antidote protein, CC2985 family
TMO_2963	COG1335	isochorismatase
TMO_2965	COG0261	This protein binds to 23S rRNA in the presence of protein L20
TMO_2966	COG0211	Belongs to the bacterial ribosomal protein bL27 family
TMO_2967	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
TMO_2969	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
TMO_2970	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
TMO_2971	COG0799	negative regulation of ribosome biogenesis
TMO_2972	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
TMO_2973	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
TMO_2974	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
TMO_2976	COG0793	Belongs to the peptidase S41A family
TMO_2978	COG0494	nUDIX hydrolase
TMO_2979	COG0725	ABC transporter, periplasmic molybdate-binding protein
TMO_2980	COG4149	molybdate abc transporter
TMO_2981	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
TMO_2984	COG0355	proton-transporting ATP synthase activity, rotational mechanism
TMO_2986	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
TMO_2987	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
TMO_2988	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
TMO_2990	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
TMO_2992	COG4974	Belongs to the 'phage' integrase family
TMO_2993	COG2132	Multicopper oxidase
TMO_2995	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
TMO_2997	COG1136	(ABC) transporter
TMO_3001	COG1595	DNA-templated transcription, initiation
TMO_3004	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
TMO_3005	COG0508	dehydrogenase complex catalyzes the overall conversion of
TMO_3008	COG0045	succinate-CoA ligase (ADP-forming) activity
TMO_3010	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
TMO_3011	COG0405	Gamma-glutamyltransferase
TMO_3012	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
TMO_3015	COG4608	Belongs to the ABC transporter superfamily
TMO_3016	COG0444	Belongs to the ABC transporter superfamily
TMO_3017	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
TMO_3018	COG0601	transmembrane transport
TMO_3019	COG0747	negative chemotaxis
TMO_3020	COG0435	Glutathione S-transferase
TMO_3021	COG0655	NAD(P)H dehydrogenase (quinone) activity
TMO_3025	COG0069	glutamate synthase activity
TMO_3025	COG0070	glutamate synthase
TMO_3025	COG0067	glutamate synthase
TMO_3028	COG0372	Belongs to the citrate synthase family
TMO_3030	COG2010	Cytochrome c
TMO_3035	COG0564	pseudouridine synthase activity
TMO_3036	COG0251	oxidation-reduction process
TMO_3037	COG0494	nUDIX hydrolase
TMO_3041	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
TMO_3043	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
TMO_3050	COG0501	Belongs to the peptidase M48B family
TMO_3053	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
TMO_3056	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
TMO_3063	COG1022	Amp-dependent synthetase and ligase
TMO_3064	COG0559	Belongs to the binding-protein-dependent transport system permease family
TMO_3067	COG0410	ABC transporter
TMO_3069	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
TMO_3074	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
TMO_3075	COG1802	Transcriptional regulator
TMO_3077	COG4133	protoheme IX ABC transporter activity
TMO_3079	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
TMO_3081	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
TMO_3082	COG1138	Cytochrome C-type biogenesis protein
TMO_3083	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
TMO_3084	COG3088	subunit of a heme lyase
TMO_3092	COG0559	Belongs to the binding-protein-dependent transport system permease family
TMO_3095	COG0410	ABC transporter
TMO_3099	COG1872	DUF167
TMO_3100	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
TMO_3108	COG0625	glutathione transferase activity
TMO_3109	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
TMO_3110	COG0535	radical SAM domain protein
TMO_3112	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
TMO_3113	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
TMO_3115	COG0820	rRNA (adenine-C2-)-methyltransferase activity
TMO_3117	COG0670	Belongs to the BI1 family
TMO_3118	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
TMO_3120	COG0138	bifunctional purine biosynthesis protein purh
TMO_3127	COG1846	Transcriptional regulator
TMO_3131	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
TMO_3135	COG2835	tetraacyldisaccharide 4'-kinase activity
TMO_3137	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
TMO_3138	COG0347	Belongs to the P(II) protein family
TMO_3139	COG0004	ammonium transporteR
TMO_3140	COG0436	Aminotransferase
TMO_3141	COG1674	ftsk spoiiie
TMO_3144	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
TMO_3146	COG1115	amino acid carrier protein
TMO_3148	COG1999	signal sequence binding
TMO_3152	COG0406	alpha-ribazole phosphatase activity
TMO_3153	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
TMO_3154	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
TMO_3156	COG1595	DNA-templated transcription, initiation
TMO_3157	COG3806	Anti-sigma factor
TMO_3159	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
TMO_3164	COG2154	pterin-4-alpha-carbinolamine dehydratase
TMO_3168	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
TMO_3171	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
TMO_3173	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
TMO_3177	COG0352	thiamine-phosphate diphosphorylase activity
TMO_3180	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
TMO_3182	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
TMO_3185	COG4172	Belongs to the ABC transporter superfamily
TMO_3186	COG4239	(ABC) transporter, permease
TMO_3187	COG4174	ABC transporter (Permease)
TMO_3188	COG4166	transmembrane transport
TMO_3190	COG3474	cytochrome
TMO_3191	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
TMO_3194	COG1396	sequence-specific DNA binding
TMO_3197	COG4181	ATPase activity
TMO_3201	COG1804	L-carnitine dehydratase bile acid-inducible protein F
TMO_3202	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
TMO_3203	COG0583	DNA-binding transcription factor activity
TMO_3205	COG0596	Alpha beta hydrolase
TMO_3209	COG1131	(ABC) transporter
TMO_3211	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
TMO_3211	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
TMO_3217	COG0071	Belongs to the small heat shock protein (HSP20) family
TMO_3219	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
TMO_3221	COG0539	negative regulation of cytoplasmic translation
TMO_3228	COG0395	ABC-type sugar transport system, permease component
TMO_3229	COG0616	signal peptide processing
TMO_3230	COG0776	regulation of translation
TMO_3233	COG0135	phosphoribosylanthranilate isomerase activity
TMO_3234	COG0133	tryptophan synthase activity
TMO_3236	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
TMO_3237	COG0285	dihydrofolate synthase activity
TMO_3242	COG1074	ATP-dependent DNA helicase activity
TMO_3243	COG2887	Belongs to the helicase family. UvrD subfamily
TMO_3244	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
TMO_3245	COG3178	'Phosphotransferase
TMO_3246	COG0802	atpase or kinase
TMO_3248	COG0228	four-way junction DNA binding
TMO_3249	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
TMO_3250	COG0336	Belongs to the RNA methyltransferase TrmD family
TMO_3251	COG0335	large ribosomal subunit rRNA binding
TMO_3252	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
TMO_3256	COG3128	pkhd-type hydroxylase
TMO_3257	COG1028	Short-chain dehydrogenase reductase Sdr
TMO_3260	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
TMO_3262	COG1024	Enoyl-CoA hydratase
TMO_3263	COG1042	CoA-binding domain protein
TMO_3263	COG0045	succinate-CoA ligase (ADP-forming) activity
TMO_3263	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
TMO_3265	COG1960	acyl-CoA dehydrogenase activity
TMO_3266	COG0531	amino acid
TMO_3268	COG3403	YqcI/YcgG family
TMO_3270	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
TMO_3272	COG2030	dehydratase
TMO_3274	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
TMO_3276	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
TMO_3277	COG1132	(ABC) transporter
TMO_3280	COG4771	TonB-dependent receptor
TMO_3283	COG3813	Protein conserved in bacteria
TMO_3284	COG0443	Heat shock 70 kDa protein
TMO_3285	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
TMO_3290	COG0463	Glycosyl transferase, family 2
TMO_3290	COG1216	Glycosyl transferase, family 2
TMO_3295	COG0583	DNA-binding transcription factor activity
TMO_3297	COG1028	Short-chain dehydrogenase reductase Sdr
TMO_3299	COG0583	DNA-binding transcription factor activity
TMO_3301	COG0288	reversible hydration of carbon dioxide
TMO_3302	COG0584	glycerophosphoryl diester phosphodiesterase
TMO_3304	COG1175	transmembrane transport
TMO_3305	COG0395	ABC-type sugar transport system, permease component
TMO_3307	COG0668	transmembrane transport
TMO_3310	COG2070	2-Nitropropane dioxygenase
TMO_3311	COG0583	DNA-binding transcription factor activity
TMO_3315	COG2095	MarC family integral membrane protein
TMO_3316	COG0248	Ppx GppA phosphatase
TMO_3317	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
TMO_3320	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
TMO_3321	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
TMO_3322	COG3135	benzoate transporter
TMO_3324	COG0584	glycerophosphoryl diester phosphodiesterase
TMO_3325	COG1042	CoA-binding domain protein
TMO_3325	COG0045	succinate-CoA ligase (ADP-forming) activity
TMO_3325	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
TMO_3328	COG0167	dihydroorotate dehydrogenase activity
TMO_3330	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
TMO_3331	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
TMO_3332	COG0302	gtp cyclohydrolase
TMO_3335	COG4136	ATPase activity
TMO_3337	COG4134	Bacterial extracellular solute-binding protein
TMO_3341	COG0473	3-isopropylmalate dehydrogenase activity
TMO_3346	COG0708	Exodeoxyribonuclease III
TMO_3347	COG0747	negative chemotaxis
TMO_3348	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
TMO_3350	COG2814	Major facilitator Superfamily
TMO_3354	COG0697	spore germination
TMO_3360	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
TMO_3361	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
TMO_3362	COG0107	imidazoleglycerol-phosphate synthase activity
TMO_3363	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
TMO_3367	COG3734	2-keto-3-deoxy-galactonokinase
TMO_3368	COG0800	Aldolase
TMO_3371	COG1858	cytochrome C peroxidase
TMO_3377	COG2207	Transcriptional regulator
TMO_3384	COG0247	lactate metabolic process
TMO_3385	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
TMO_3389	COG0367	asparagine synthase
TMO_3392	COG2124	cytochrome p450
TMO_3395	COG3030	protein affecting phage T7 exclusion by the F plasmid
TMO_3396	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
TMO_3397	COG0583	DNA-binding transcription factor activity
TMO_3402	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
TMO_3404	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
TMO_3405	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
TMO_3406	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
TMO_3408	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
TMO_3411	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
TMO_3412	COG1331	Highly conserved protein containing a thioredoxin domain
TMO_3414	COG3411	Ferredoxin
TMO_3415	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
TMO_3416	COG0445	tRNA wobble uridine modification
TMO_3418	COG1192	Involved in chromosome partitioning
TMO_3419	COG1475	DNA binding
TMO_3426	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
TMO_3435	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
TMO_3435	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
TMO_3438	COG0438	transferase activity, transferring glycosyl groups
TMO_3440	COG0745	RESPONSE REGULATOR receiver
TMO_3444	COG1024	Enoyl-CoA hydratase
TMO_3445	COG1396	sequence-specific DNA binding
TMO_3448	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
TMO_3450	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
TMO_3451	COG2223	nitrite transmembrane transporter activity
TMO_3453	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
TMO_3458	COG2188	Transcriptional regulator
TMO_3460	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
TMO_3461	COG1396	sequence-specific DNA binding
TMO_3466	COG0792	nuclease activity
TMO_3467	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
TMO_3469	COG0635	Involved in the biosynthesis of porphyrin-containing compound
TMO_3470	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
TMO_3471	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
TMO_3472	COG1420	regulation of RNA biosynthetic process
TMO_3473	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
TMO_3475	COG0484	heat shock protein binding
TMO_3476	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
TMO_3477	COG0697	spore germination
TMO_3478	COG3243	poly(R)-hydroxyalkanoic acid synthase
TMO_3480	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
TMO_3481	COG1129	ABC transporter
TMO_3481	COG0842	Transport permease protein
TMO_3482	COG0842	Transport permease protein
TMO_3483	COG3550	peptidyl-serine autophosphorylation
TMO_3485	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
TMO_3488	COG4149	molybdate abc transporter
TMO_3489	COG1840	ABC-type Fe3 transport system, periplasmic component
TMO_3490	COG1609	Transcriptional regulator
TMO_3491	COG0728	peptidoglycan biosynthetic process
TMO_3494	COG1464	Belongs to the NlpA lipoprotein family
TMO_3495	COG0840	transmembrane signaling receptor activity
TMO_3498	COG0392	lysyltransferase activity
TMO_3498	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
TMO_3501	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
TMO_3502	COG0281	malic enzyme
TMO_3502	COG0280	phosphate acetyltransferase
TMO_3503	COG5002	protein histidine kinase activity
TMO_3504	COG0318	PFAM AMP-dependent synthetase and ligase
TMO_3505	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
TMO_3506	COG0573	inorganic phosphate transmembrane transporter activity
TMO_3509	COG0704	Plays a role in the regulation of phosphate uptake
TMO_3510	COG0745	RESPONSE REGULATOR receiver
TMO_3511	COG1280	lysine exporter protein (LysE YggA)
TMO_3512	COG0180	Tryptophanyl-tRNA synthetase
TMO_3513	COG0730	response to heat
TMO_3517	COG0789	Transcriptional regulator
TMO_3519	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
TMO_3520	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
TMO_3521	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
TMO_3526	COG0456	acetyltransferase
TMO_3526	COG1214	PFAM Peptidase M22, glycoprotease
TMO_3531	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
TMO_3532	COG1702	phosphate starvation-inducible protein PhoH
TMO_3533	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
TMO_3534	COG1253	flavin adenine dinucleotide binding
TMO_3535	COG0815	Transfers the fatty acyl group on membrane lipoproteins
TMO_3536	COG1396	sequence-specific DNA binding
TMO_3537	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
TMO_3538	COG0220	tRNA (guanine-N7-)-methyltransferase activity
TMO_3543	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
TMO_3544	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
TMO_3545	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
TMO_3546	COG1185	polyribonucleotide nucleotidyltransferase activity
TMO_3554	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
TMO_3556	COG1959	2 iron, 2 sulfur cluster binding
TMO_3557	COG0756	dUTP diphosphatase activity
TMO_3558	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
TMO_3559	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
TMO_3560	COG2226	methyltransferase
TMO_3561	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
TMO_3563	COG1024	Enoyl-CoA hydratase
TMO_3564	COG0268	Binds directly to 16S ribosomal RNA
TMO_a0001	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
TMO_a0004	COG3609	addiction module antidote protein, CC2985 family
TMO_a0011	COG2423	ornithine cyclodeaminase activity
TMO_a0015	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
TMO_a0024	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
TMO_a0025	COG0601	transmembrane transport
TMO_a0026	COG0601	transmembrane transport
TMO_a0027	COG0747	negative chemotaxis
TMO_a0028	COG2205	protein histidine kinase activity
TMO_a0029	COG0745	RESPONSE REGULATOR receiver
TMO_a0030	COG0671	phosphoesterase, PA-phosphatase related
TMO_a0034	COG1262	PFAM Formylglycine-generating sulfatase enzyme
TMO_a0035	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
TMO_a0049	COG1522	sequence-specific DNA binding
TMO_a0052	COG3932	Exopolysaccharide synthesis, ExoD
TMO_a0053	COG5001	Diguanylate cyclase
TMO_a0053	COG3300	MHYT domain
TMO_a0054	COG1881	PFAM PEBP family protein
TMO_a0056	COG0483	inositol monophosphate 1-phosphatase activity
TMO_a0068	COG3501	Rhs element vgr protein
TMO_a0072	COG1136	(ABC) transporter
TMO_a0075	COG0631	protein serine/threonine phosphatase activity
TMO_a0078	COG2885	chlorophyll binding
TMO_a0078	COG3047	cAMP biosynthetic process
TMO_a0095	COG3501	Rhs element vgr protein
TMO_a0098	COG3209	COG3209 Rhs family protein
TMO_a0105	COG5642	Protein of unknown function (DUF2384)
TMO_a0106	COG5654	RES domain protein
TMO_a0111	COG2814	Major facilitator Superfamily
TMO_a0116	COG3668	Plasmid stabilization system
TMO_a0118	COG1132	(ABC) transporter
TMO_a0120	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
TMO_a0122	COG1120	ATPase activity
TMO_a0123	COG4774	siderophore transport
TMO_a0124	COG2207	Transcriptional regulator
TMO_a0127	COG4608	Belongs to the ABC transporter superfamily
TMO_a0128	COG0444	Belongs to the ABC transporter superfamily
TMO_a0130	COG0601	transmembrane transport
TMO_a0131	COG0747	negative chemotaxis
TMO_a0134	COG0583	DNA-binding transcription factor activity
TMO_a0135	COG1028	Short-chain dehydrogenase reductase Sdr
TMO_a0138	COG1960	acyl-CoA dehydrogenase activity
TMO_a0140	COG1960	acyl-CoA dehydrogenase activity
TMO_a0145	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
TMO_a0146	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
TMO_a0147	COG0235	Class ii aldolase
TMO_a0153	COG2204	response regulator
TMO_a0158	COG0439	Biotin carboxylase
TMO_a0160	COG2030	dehydratase
TMO_a0161	COG1028	Short-chain dehydrogenase reductase Sdr
TMO_a0162	COG1960	acyl-CoA dehydrogenase activity
TMO_a0166	COG0559	Belongs to the binding-protein-dependent transport system permease family
TMO_a0169	COG1309	transcriptional regulator
TMO_a0171	COG1309	transcriptional regulator
TMO_a0174	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
TMO_a0180	COG0702	epimerase
TMO_a0181	COG1012	belongs to the aldehyde dehydrogenase family
TMO_a0185	COG0583	DNA-binding transcription factor activity
TMO_a0188	COG1294	oxidase, subunit
TMO_a0189	COG1271	oxidase subunit
TMO_a0190	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
TMO_a0191	COG4988	ABC transporter
TMO_a0193	COG0840	transmembrane signaling receptor activity
TMO_a0195	COG0300	oxidoreductase activity
TMO_a0196	COG2226	methyltransferase
TMO_a0203	COG1487	ribonuclease activity
TMO_a0207	COG0659	secondary active sulfate transmembrane transporter activity
TMO_a0215	COG0366	Alpha amylase catalytic
TMO_a0219	COG1877	trehalose-phosphatase activity
TMO_a0220	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
TMO_a0223	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
TMO_a0225	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
TMO_a0228	COG0559	Belongs to the binding-protein-dependent transport system permease family
TMO_a0231	COG0410	ABC transporter
TMO_a0234	COG0318	PFAM AMP-dependent synthetase and ligase
TMO_a0243	COG2205	protein histidine kinase activity
TMO_a0243	COG0784	Response regulator, receiver
TMO_a0243	COG5002	protein histidine kinase activity
TMO_a0245	COG1172	Belongs to the binding-protein-dependent transport system permease family
TMO_a0246	COG1172	Belongs to the binding-protein-dependent transport system permease family
TMO_a0247	COG1129	ABC transporter
TMO_a0248	COG1879	ABC-type sugar transport system periplasmic component
TMO_a0250	COG3386	PFAM SMP-30 Gluconolaconase
TMO_a0256	COG4214	carbohydrate transport
TMO_a0258	COG4213	ABC transporter substrate-binding protein
TMO_a0265	COG1309	transcriptional regulator
TMO_a0271	COG1309	transcriptional regulator
TMO_a0272	COG1028	Short-chain dehydrogenase reductase Sdr
TMO_a0273	COG3634	alkyl hydroperoxide reductase activity
TMO_a0274	COG1959	2 iron, 2 sulfur cluster binding
TMO_a0278	COG0302	gtp cyclohydrolase
TMO_a0283	COG1802	Transcriptional regulator
TMO_a0285	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
TMO_a0287	COG1335	isochorismatase
TMO_a0289	COG0667	Aldo Keto reductase
TMO_a0295	COG0559	Belongs to the binding-protein-dependent transport system permease family
TMO_a0300	COG1804	L-carnitine dehydratase bile acid-inducible protein F
TMO_a0302	COG1902	pentaerythritol trinitrate reductase activity
TMO_a0303	COG0668	transmembrane transport
TMO_a0304	COG1529	Aldehyde oxidase and xanthine dehydrogenase
TMO_a0305	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
TMO_a0306	COG2080	2 iron, 2 sulfur cluster binding
TMO_a0309	COG1278	Cold shock
TMO_a0310	COG1278	Cold shock
TMO_a0312	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
TMO_a0315	COG1028	Short-chain dehydrogenase reductase Sdr
TMO_a0317	COG0500	methyltransferase
TMO_a0324	COG1032	radical SAM domain protein
TMO_a0325	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
TMO_a0332	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
TMO_a0334	COG4993	Dehydrogenase
TMO_a0347	COG0154	amidase activity
TMO_a0349	COG0747	negative chemotaxis
TMO_a0357	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
TMO_a0370	COG3344	reverse transcriptase
TMO_a0372	COG4227	nucleotidyltransferase activity
TMO_a0377	COG1472	Belongs to the glycosyl hydrolase 3 family
TMO_a0378	COG3473	Maleate cis-trans isomerase
TMO_a0379	COG1309	transcriptional regulator
TMO_a0385	COG1021	2,3-dihydroxybenzoate-AMP ligase
TMO_a0386	COG1309	transcriptional regulator
TMO_a0389	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
TMO_a0391	COG4106	trans-aconitate 2-methyltransferase activity
TMO_a0395	COG1309	transcriptional regulator
TMO_a0396	COG1053	succinate dehydrogenase
TMO_a0397	COG1902	pentaerythritol trinitrate reductase activity
TMO_a0398	COG2188	Transcriptional regulator
TMO_a0400	COG0559	Belongs to the binding-protein-dependent transport system permease family
TMO_a0403	COG0410	ABC transporter
TMO_a0407	COG1053	succinate dehydrogenase
TMO_a0420	COG2186	Transcriptional regulator
TMO_a0426	COG1696	Membrane protein involved in D-alanine export
TMO_a0433	COG1546	Belongs to the CinA family
TMO_a0433	COG1058	Belongs to the CinA family
TMO_a0439	COG2079	MmgE PrpD family protein
TMO_a0440	COG2030	dehydratase
TMO_a0441	COG1960	acyl-CoA dehydrogenase activity
TMO_a0447	COG1024	Enoyl-CoA hydratase
TMO_a0452	COG1960	acyl-CoA dehydrogenase activity
TMO_a0454	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
TMO_a0462	COG1024	Enoyl-CoA hydratase
TMO_a0464	COG0318	PFAM AMP-dependent synthetase and ligase
TMO_a0466	COG2205	protein histidine kinase activity
TMO_a0466	COG2202	Pas domain
TMO_a0467	COG1742	UPF0060 membrane protein
TMO_a0470	COG2198	Histidine kinase
TMO_a0470	COG0784	Response regulator, receiver
TMO_a0470	COG2205	protein histidine kinase activity
TMO_a0471	COG3706	GGDEF domain
TMO_a0471	COG0745	RESPONSE REGULATOR receiver
TMO_a0483	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
TMO_a0486	COG3510	cephalosporin hydroxylase
TMO_a0487	COG4122	O-methyltransferase activity
TMO_a0494	COG3246	L-lysine catabolic process to acetate
TMO_a0496	COG0559	Belongs to the binding-protein-dependent transport system permease family
TMO_a0501	COG2030	dehydratase
TMO_a0502	COG1028	Short-chain dehydrogenase reductase Sdr
TMO_a0503	COG1024	Enoyl-CoA hydratase
TMO_a0504	COG1846	Transcriptional regulator
TMO_a0505	COG1028	Short-chain dehydrogenase reductase Sdr
TMO_a0507	COG1024	Enoyl-CoA hydratase
TMO_a0508	COG1028	Short-chain dehydrogenase reductase Sdr
TMO_a0509	COG0318	PFAM AMP-dependent synthetase and ligase
TMO_a0510	COG1960	acyl-CoA dehydrogenase activity
TMO_a0511	COG1960	acyl-CoA dehydrogenase activity
TMO_a0516	COG1960	acyl-CoA dehydrogenase activity
TMO_a0519	COG1804	L-carnitine dehydratase bile acid-inducible protein F
TMO_a0520	COG1960	acyl-CoA dehydrogenase activity
TMO_a0521	COG1024	Enoyl-CoA hydratase
TMO_a0522	COG1917	Cupin 2, conserved barrel domain protein
TMO_a0522	COG4977	sequence-specific DNA binding
TMO_a0524	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
TMO_a0525	COG1024	Enoyl-CoA hydratase
TMO_a0526	COG1902	pentaerythritol trinitrate reductase activity
TMO_a0532	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
TMO_a0534	COG4585	Histidine kinase
TMO_a0540	COG1024	Enoyl-CoA hydratase
TMO_a0542	COG0318	PFAM AMP-dependent synthetase and ligase
TMO_a0550	COG2271	Major facilitator Superfamily
TMO_a0567	COG1473	amidohydrolase
TMO_a0570	COG0318	PFAM AMP-dependent synthetase and ligase
TMO_a0573	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
TMO_a0577	COG3712	iron ion homeostasis
TMO_a0578	COG1595	DNA-templated transcription, initiation
TMO_a0581	COG0367	asparagine synthase
TMO_a0581	COG0367	asparagine synthase
TMO_a0583	COG1024	Enoyl-CoA hydratase
TMO_a0587	COG1696	Membrane protein involved in D-alanine export
TMO_a0591	COG0583	DNA-binding transcription factor activity
TMO_a0593	COG3077	Addiction module antitoxin, RelB DinJ family
TMO_a0598	COG3550	peptidyl-serine autophosphorylation
TMO_a0599	COG1396	sequence-specific DNA binding
TMO_a0600	COG0753	catalase activity
TMO_a0602	COG1573	uracil-dna glycosylase
TMO_b0019	COG0004	ammonium transporteR
TMO_b0020	COG2175	clavaminate synthase activity
TMO_b0021	COG0235	Class ii aldolase
TMO_b0022	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
TMO_b0023	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
TMO_b0025	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
TMO_b0027	COG2186	Transcriptional regulator
TMO_b0028	COG2205	protein histidine kinase activity
TMO_b0028	COG0784	Response regulator, receiver
TMO_b0028	COG5002	protein histidine kinase activity
TMO_b0029	COG3437	response regulator, receiver
TMO_b0030	COG2814	Major facilitator Superfamily
TMO_b0031	COG0583	DNA-binding transcription factor activity
TMO_b0032	COG0659	secondary active sulfate transmembrane transporter activity
TMO_b0035	COG1309	transcriptional regulator
TMO_b0036	COG1132	(ABC) transporter
TMO_b0040	COG4172	Belongs to the ABC transporter superfamily
TMO_b0048	COG1566	PFAM secretion protein HlyD family protein
TMO_b0051	COG2207	Transcriptional regulator
TMO_b0057	COG0765	amino acid transport
TMO_b0058	COG1126	abc transporter atp-binding protein
TMO_b0059	COG4948	Mandelate Racemase Muconate Lactonizing
TMO_b0060	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
TMO_b0061	COG0028	Belongs to the TPP enzyme family
TMO_b0062	COG0583	DNA-binding transcription factor activity
TMO_b0066	COG0534	Mate efflux family protein
TMO_b0075	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
TMO_b0077	COG1024	Enoyl-CoA hydratase
TMO_b0080	COG4774	siderophore transport
TMO_b0081	COG2382	esterase
TMO_b0087	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
TMO_b0090	COG0765	amino acid transport
TMO_b0092	COG1126	abc transporter atp-binding protein
TMO_b0094	COG3938	Belongs to the proline racemase family
TMO_b0096	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
TMO_b0097	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
TMO_b0100	COG0395	ABC-type sugar transport system, permease component
TMO_b0102	COG3842	ATPase activity
TMO_b0103	COG3842	ATPase activity
TMO_b0107	COG1294	oxidase, subunit
TMO_b0108	COG1271	oxidase subunit
TMO_b0109	COG0318	PFAM AMP-dependent synthetase and ligase
TMO_b0113	COG2267	carboxylic ester hydrolase activity
TMO_b0115	COG3384	dioxygenase
TMO_b0121	COG3971	2-oxopent-4-enoate hydratase activity
TMO_b0127	COG3706	GGDEF domain
TMO_b0128	COG2081	HI0933 family
TMO_b0129	COG2205	protein histidine kinase activity
TMO_b0129	COG5002	protein histidine kinase activity
TMO_b0129	COG0784	Response regulator, receiver
TMO_b0136	COG1280	lysine exporter protein (LysE YggA)
TMO_b0137	COG0367	asparagine synthase
TMO_b0138	COG2226	methyltransferase
TMO_b0139	COG0583	DNA-binding transcription factor activity
TMO_b0144	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
TMO_b0145	COG1309	transcriptional regulator
TMO_b0149	COG1741	Belongs to the pirin family
TMO_b0152	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
TMO_b0154	COG3077	Addiction module antitoxin, RelB DinJ family
TMO_b0156	COG0028	Belongs to the TPP enzyme family
TMO_b0157	COG2124	cytochrome p450
TMO_b0158	COG2032	superoxide dismutase activity
TMO_b0159	COG3119	arylsulfatase activity
TMO_b0167	COG1028	Short-chain dehydrogenase reductase Sdr
TMO_b0171	COG2188	Transcriptional regulator
TMO_b0172	COG0427	acetyl-CoA hydrolase
TMO_b0177	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
TMO_b0178	COG1028	Short-chain dehydrogenase reductase Sdr
TMO_b0179	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
TMO_b0182	COG2814	Major facilitator Superfamily
TMO_b0187	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
TMO_b0188	COG0318	PFAM AMP-dependent synthetase and ligase
TMO_b0189	COG3706	GGDEF domain
TMO_b0196	COG2807	transmembrane transport
TMO_b0197	COG1309	transcriptional regulator
TMO_b0198	COG1335	isochorismatase
TMO_b0199	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
TMO_b0200	COG1116	anion transmembrane transporter activity
TMO_b0201	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
TMO_b0205	COG1309	transcriptional regulator
TMO_b0210	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
TMO_b0214	COG2207	Transcriptional regulator
TMO_b0216	COG1028	Short-chain dehydrogenase reductase Sdr
TMO_b0217	COG0753	catalase activity
TMO_b0219	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
TMO_b0220	COG1120	ATPase activity
TMO_b0221	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
TMO_b0222	COG4774	siderophore transport
TMO_b0223	COG0745	RESPONSE REGULATOR receiver
TMO_b0225	COG2205	protein histidine kinase activity
TMO_b0228	COG0667	Aldo Keto reductase
TMO_b0229	COG2202	Pas domain
TMO_b0229	COG3920	Histidine kinase
TMO_b0233	COG1309	transcriptional regulator
TMO_b0234	COG0318	PFAM AMP-dependent synthetase and ligase
TMO_b0235	COG0410	ABC transporter
TMO_b0236	COG0411	ABC transporter
TMO_b0240	COG0318	PFAM AMP-dependent synthetase and ligase
TMO_b0242	COG1960	acyl-CoA dehydrogenase activity
TMO_b0243	COG1960	acyl-CoA dehydrogenase activity
TMO_b0249	COG1028	Short-chain dehydrogenase reductase Sdr
TMO_b0251	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
TMO_b0258	COG1671	Belongs to the UPF0178 family
TMO_b0260	COG1414	Transcriptional regulator
TMO_b0262	COG0154	amidase activity
TMO_b0263	COG2808	Putative FMN-binding domain
TMO_b0265	COG4172	Belongs to the ABC transporter superfamily
TMO_b0267	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
TMO_b0268	COG0747	negative chemotaxis
TMO_b0270	COG1917	Cupin 2, conserved barrel domain protein
TMO_b0270	COG2169	Transcriptional regulator
TMO_b0274	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
TMO_b0287	COG0667	Aldo Keto reductase
TMO_b0288	COG1028	Short-chain dehydrogenase reductase Sdr
TMO_b0291	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
TMO_b0292	COG0045	succinate-CoA ligase (ADP-forming) activity
TMO_b0292	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
TMO_b0292	COG1042	CoA-binding domain protein
TMO_b0293	COG1960	acyl-CoA dehydrogenase activity
TMO_b0294	COG1960	acyl-CoA dehydrogenase activity
TMO_b0296	COG1024	Enoyl-CoA hydratase
TMO_b0297	COG3609	addiction module antidote protein, CC2985 family
TMO_b0299	COG2814	Major facilitator Superfamily
TMO_b0302	COG0438	transferase activity, transferring glycosyl groups
TMO_b0303	COG2205	protein histidine kinase activity
TMO_b0306	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
TMO_b0319	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
TMO_b0330	COG2366	antibiotic biosynthetic process
TMO_b0331	COG4774	siderophore transport
TMO_b0332	COG1120	ATPase activity
TMO_b0333	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
TMO_b0341	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
TMO_b0342	COG1522	sequence-specific DNA binding
TMO_b0344	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
TMO_b0346	COG0573	inorganic phosphate transmembrane transporter activity
TMO_b0347	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
TMO_b0352	COG3842	ATPase activity
TMO_b0354	COG0235	Class ii aldolase
TMO_b0355	COG1942	4-Oxalocrotonate Tautomerase
TMO_b0356	COG0583	DNA-binding transcription factor activity
TMO_b0358	COG1191	sigma factor activity
TMO_b0362	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
TMO_b0366	COG0318	PFAM AMP-dependent synthetase and ligase
TMO_b0367	COG1024	Enoyl-CoA hydratase
TMO_b0368	COG1960	acyl-CoA dehydrogenase activity
TMO_b0369	COG2186	Transcriptional regulator
TMO_b0370	COG2205	protein histidine kinase activity
TMO_b0370	COG2198	Histidine kinase
TMO_b0370	COG0784	Response regulator, receiver
TMO_b0371	COG2197	response regulator
TMO_b0372	COG3842	ATPase activity
TMO_b0374	COG0395	ABC-type sugar transport system, permease component
TMO_b0376	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
TMO_b0379	COG4172	Belongs to the ABC transporter superfamily
TMO_b0381	COG0601	transmembrane transport
TMO_b0382	COG0747	negative chemotaxis
TMO_b0383	COG0583	DNA-binding transcription factor activity
TMO_b0385	COG0154	amidase activity
TMO_b0388	COG2030	dehydratase
TMO_b0391	COG1960	acyl-CoA dehydrogenase activity
TMO_b0392	COG0667	Aldo Keto reductase
TMO_b0399	COG1846	Transcriptional regulator
TMO_b0401	COG1309	transcriptional regulator
TMO_b0402	COG1233	COG1233 Phytoene dehydrogenase and related
TMO_b0405	COG0410	ABC transporter
TMO_b0406	COG0411	ABC transporter
TMO_b0408	COG0559	Belongs to the binding-protein-dependent transport system permease family
TMO_b0412	COG1012	belongs to the aldehyde dehydrogenase family
TMO_b0413	COG0583	DNA-binding transcription factor activity
TMO_b0414	COG1012	belongs to the aldehyde dehydrogenase family
TMO_b0419	COG0740	serine-type endopeptidase activity
TMO_b0420	COG3706	GGDEF domain
TMO_b0424	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
TMO_b0425	COG1250	3-hydroxyacyl-CoA dehydrogenase
TMO_b0426	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
TMO_b0432	COG3971	2-oxopent-4-enoate hydratase activity
TMO_b0437	COG1802	Transcriptional regulator
TMO_b0439	COG0179	Fumarylacetoacetate (FAA) hydrolase
TMO_b0441	COG0559	Belongs to the binding-protein-dependent transport system permease family
TMO_b0443	COG1137	ATPase activity
TMO_b0444	COG0410	ABC transporter
TMO_b0445	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
TMO_b0446	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
TMO_b0450	COG2223	nitrite transmembrane transporter activity
TMO_b0451	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
TMO_b0452	COG1140	nitrate reductase beta subunit
TMO_b0453	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
TMO_b0454	COG2181	nitrate reductase activity
TMO_b0455	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
TMO_b0459	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
TMO_b0460	COG0521	Mo-molybdopterin cofactor biosynthetic process
TMO_b0462	COG3706	GGDEF domain
TMO_b0463	COG2199	diguanylate cyclase activity
TMO_b0464	COG1126	abc transporter atp-binding protein
TMO_b0465	COG4597	amino acid ABC transporter
TMO_b0466	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
TMO_b0468	COG0625	glutathione transferase activity
TMO_b0469	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
TMO_b0469	COG2022	thiamine diphosphate biosynthetic process
TMO_b0470	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
TMO_b0471	COG0583	DNA-binding transcription factor activity
TMO_b0476	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
TMO_b0480	COG0003	Pfam Anion-transporting ATPase
TMO_b0483	COG1132	(ABC) transporter
TMO_b0486	COG1752	Esterase of the alpha-beta hydrolase superfamily
TMO_b0490	COG0671	phosphoesterase, PA-phosphatase related
TMO_b0491	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
TMO_b0493	COG0747	negative chemotaxis
TMO_b0494	COG4608	Belongs to the ABC transporter superfamily
TMO_b0495	COG0444	Belongs to the ABC transporter superfamily
TMO_b0503	COG2207	Transcriptional regulator
TMO_b0509	COG1733	regulation of RNA biosynthetic process
TMO_b0517	COG1802	Transcriptional regulator
TMO_b0518	COG1072	(Pantothenic acid kinase))
TMO_b0521	COG0583	DNA-binding transcription factor activity
TMO_b0522	COG0655	NAD(P)H dehydrogenase (quinone) activity
TMO_b0523	COG2264	protein methyltransferase activity
TMO_b0525	COG2072	flavoprotein involved in K transport
TMO_b0529	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
TMO_b0531	COG3609	addiction module antidote protein, CC2985 family
TMO_b0532	COG0668	transmembrane transport
TMO_b0534	COG0450	alkyl hydroperoxide reductase
TMO_b0537	COG2207	Transcriptional regulator
TMO_b0537	COG3708	Transcriptional regulator
TMO_b0538	COG2814	Major facilitator Superfamily
TMO_b0540	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
TMO_b0541	COG4311	Sarcosine oxidase, delta subunit
TMO_b0542	COG0446	pyridine nucleotide-disulphide oxidoreductase
TMO_b0542	COG0404	The glycine cleavage system catalyzes the degradation of glycine
TMO_b0546	COG0066	3-isopropylmalate dehydratase activity
TMO_b0547	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
TMO_b0549	COG1960	acyl-CoA dehydrogenase activity
TMO_b0553	COG2188	Transcriptional regulator
TMO_b0560	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
TMO_b0561	COG0318	PFAM AMP-dependent synthetase and ligase
TMO_b0562	COG2188	Transcriptional regulator
TMO_b0569	COG1960	acyl-CoA dehydrogenase activity
TMO_b0572	COG0840	transmembrane signaling receptor activity
TMO_b0574	COG0242	peptide deformylase activity
TMO_b0575	COG0300	oxidoreductase activity
TMO_b0576	COG0583	DNA-binding transcription factor activity
TMO_b0577	COG1309	transcriptional regulator
TMO_b0578	COG1028	Short-chain dehydrogenase reductase Sdr
TMO_b0581	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
TMO_b0587	COG1475	DNA binding
TMO_b0591	COG1902	pentaerythritol trinitrate reductase activity
TMO_b0591	COG0446	pyridine nucleotide-disulphide oxidoreductase
TMO_b0593	COG4977	sequence-specific DNA binding
TMO_b0594	COG2814	Major facilitator Superfamily
TMO_c0005	COG0583	DNA-binding transcription factor activity
TMO_c0009	COG2217	Heavy metal translocating P-type atpase
TMO_c0012	COG2132	Multicopper oxidase
TMO_c0013	COG0745	RESPONSE REGULATOR receiver
TMO_c0014	COG5002	protein histidine kinase activity
TMO_c0015	COG0640	Transcriptional regulator
TMO_c0018	COG0798	PFAM Bile acid sodium symporter
TMO_c0020	COG1695	Transcriptional regulator
TMO_c0035	COG2003	Belongs to the UPF0758 family
TMO_c0046	COG3311	Transcriptional regulator
TMO_c0047	COG1569	PIN domain
TMO_c0048	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
TMO_c0076	COG0789	Transcriptional regulator
TMO_c0082	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
TMO_c0084	COG0789	Transcriptional regulator
TMO_c0087	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
TMO_c0088	COG0629	single-stranded DNA binding
TMO_c0095	COG1192	Involved in chromosome partitioning
TMO_c0100	COG2234	aminopeptidase activity
TMO_c0102	COG0133	tryptophan synthase activity
TMO_c0103	COG0133	tryptophan synthase activity
TMO_c0106	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
TMO_c0107	COG0358	DNA primase activity
TMO_c0109	COG0505	Belongs to the CarA family
TMO_c0110	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
TMO_c0111	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
TMO_c0113	COG3180	Ammonia monooxygenase
TMO_c0114	COG1522	sequence-specific DNA binding
TMO_c0115	COG3660	Nucleoside-diphosphate-sugar epimerase
TMO_c0116	COG0492	ferredoxin-NADP+ reductase activity
TMO_c0117	COG0583	DNA-binding transcription factor activity
TMO_c0125	COG0556	nucleotide-excision repair
TMO_c0126	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
TMO_c0127	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
TMO_c0128	COG1028	Short-chain dehydrogenase reductase Sdr
TMO_c0129	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
TMO_c0131	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
TMO_c0134	COG1191	sigma factor activity
TMO_c0138	COG1733	regulation of RNA biosynthetic process
TMO_c0139	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
TMO_c0140	COG1846	Transcriptional regulator
TMO_c0141	COG0745	RESPONSE REGULATOR receiver
TMO_c0142	COG2205	protein histidine kinase activity
TMO_c0144	COG3706	GGDEF domain
TMO_c0145	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
TMO_c0148	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
TMO_c0149	COG1028	Short-chain dehydrogenase reductase Sdr
TMO_c0149	COG3347	Dehydrogenase
TMO_c0151	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
TMO_c0155	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
TMO_c0156	COG0408	coproporphyrinogen oxidase activity
TMO_c0164	COG0494	nUDIX hydrolase
TMO_c0165	COG1960	acyl-CoA dehydrogenase activity
TMO_c0166	COG1309	transcriptional regulator
TMO_c0175	COG1002	Type II restriction enzyme, methylase subunits
TMO_c0178	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
TMO_c0184	COG2264	protein methyltransferase activity
TMO_c0185	COG0210	DNA helicase
TMO_c0191	COG0737	Belongs to the 5'-nucleotidase family
TMO_c0193	COG0277	FAD linked oxidase domain protein
TMO_c0196	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
TMO_c0198	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
TMO_c0203	COG2144	transferase activity, transferring acyl groups
TMO_c0204	COG0438	transferase activity, transferring glycosyl groups
TMO_c0206	COG2072	flavoprotein involved in K transport
TMO_c0208	COG4221	oxidoreductase activity
TMO_c0211	COG1250	3-hydroxyacyl-CoA dehydrogenase
TMO_c0213	COG2072	flavoprotein involved in K transport
TMO_c0214	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
TMO_c0217	COG0842	Transport permease protein
TMO_c0218	COG0842	Transport permease protein
TMO_c0219	COG0842	Transport permease protein
TMO_c0220	COG1131	(ABC) transporter
TMO_c0227	COG4638	Rieske (2fe-2S)
TMO_c0229	COG2030	dehydratase
TMO_c0229	COG1012	belongs to the aldehyde dehydrogenase family
TMO_c0230	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
TMO_c0231	COG0497	DNA recombination
TMO_c0232	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
TMO_c0233	COG1396	sequence-specific DNA binding
TMO_c0234	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
TMO_c0235	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
TMO_c0236	COG0849	cell division
TMO_c0237	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
TMO_c0238	COG1181	Belongs to the D-alanine--D-alanine ligase family
TMO_c0239	COG0812	UDP-N-acetylmuramate dehydrogenase activity
TMO_c0240	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
TMO_c0241	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
TMO_c0243	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
TMO_c0245	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
TMO_c0246	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
TMO_c0255	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
TMO_c0256	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
TMO_c0267	COG1396	sequence-specific DNA binding
TMO_c0271	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
TMO_c0272	COG0697	spore germination
TMO_c0273	COG1733	regulation of RNA biosynthetic process
TMO_c0274	COG0625	glutathione transferase activity
TMO_c0276	COG1942	4-Oxalocrotonate Tautomerase
TMO_c0278	COG1773	rubredoxin
TMO_c0280	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
TMO_c0281	COG0505	Belongs to the CarA family
TMO_c0284	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
TMO_c0285	COG2814	Major facilitator Superfamily
TMO_c0286	COG0583	DNA-binding transcription factor activity
TMO_c0287	COG0667	Aldo Keto reductase
TMO_c0291	COG3045	CreA protein
TMO_c0292	COG1704	LemA family
TMO_c0293	COG0501	Belongs to the peptidase M48B family
TMO_c0294	COG1720	tRNA m6t6A37 methyltransferase activity
TMO_c0295	COG1028	Short-chain dehydrogenase reductase Sdr
TMO_c0299	COG0754	glutathionylspermidine amidase activity
TMO_c0301	COG0784	Response regulator, receiver
TMO_c0301	COG2205	protein histidine kinase activity
TMO_c0302	COG2205	protein histidine kinase activity
TMO_c0309	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
TMO_c0312	COG1473	amidohydrolase
TMO_c0317	COG3742	Toxic component of a toxin-antitoxin (TA) module. An RNase
TMO_c0330	COG3220	belongs to the UPF0276 family
TMO_c0333	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
TMO_c0334	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
TMO_c0335	COG1620	l-lactate permease
TMO_c0337	COG0798	PFAM Bile acid sodium symporter
TMO_c0345	COG3246	L-lysine catabolic process to acetate
TMO_c0347	COG0601	transmembrane transport
TMO_c0349	COG4172	Belongs to the ABC transporter superfamily
TMO_c0351	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
TMO_c0354	COG2814	Major facilitator Superfamily
TMO_c0355	COG1733	regulation of RNA biosynthetic process
TMO_c0358	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
TMO_c0359	COG0066	3-isopropylmalate dehydratase activity
TMO_c0366	COG2944	sequence-specific DNA binding
TMO_c0368	COG0318	PFAM AMP-dependent synthetase and ligase
TMO_c0369	COG1028	Short-chain dehydrogenase reductase Sdr
TMO_c0376	COG1953	Uracil, thiamine, allantoin
TMO_c0381	COG1309	transcriptional regulator
TMO_c0382	COG0483	inositol monophosphate 1-phosphatase activity
TMO_c0384	COG1518	maintenance of DNA repeat elements
TMO_c0391	COG1741	Belongs to the pirin family
TMO_c0397	COG1733	regulation of RNA biosynthetic process
TMO_c0399	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
TMO_c0405	COG1129	ABC transporter
TMO_c0408	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
TMO_c0413	COG0667	Aldo Keto reductase
TMO_c0414	COG1309	transcriptional regulator
TMO_c0420	COG0477	Major facilitator Superfamily
TMO_c0421	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
TMO_c0424	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
TMO_c0429	COG0183	Belongs to the thiolase family
TMO_c0431	COG0411	ABC transporter
TMO_c0434	COG1028	Short-chain dehydrogenase reductase Sdr
TMO_c0437	COG2080	2 iron, 2 sulfur cluster binding
TMO_c0438	COG2207	Transcriptional regulator
TMO_c0439	COG0586	Pfam SNARE associated Golgi protein
TMO_c0440	COG0420	3'-5' exonuclease activity
TMO_c0441	COG0419	ATPase involved in DNA repair
TMO_c0442	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
TMO_c0443	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
TMO_c0444	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
TMO_c0445	COG0154	amidase activity
TMO_c0446	COG1228	amidohydrolase
TMO_c0451	COG0601	transmembrane transport
TMO_c0452	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
TMO_c0453	COG0444	Belongs to the ABC transporter superfamily
TMO_c0454	COG4608	Belongs to the ABC transporter superfamily
TMO_c0455	COG2515	1-aminocyclopropane-1-carboxylate deaminase
TMO_c0456	COG1522	sequence-specific DNA binding
TMO_c0457	COG1252	NADH dehydrogenase
TMO_c0462	COG0765	amino acid transport
TMO_c0464	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
TMO_c0465	COG2186	Transcriptional regulator
TMO_c0466	COG4266	Belongs to the allantoicase family
TMO_c0467	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
TMO_c0475	COG1959	2 iron, 2 sulfur cluster binding
TMO_c0478	COG0247	lactate metabolic process
TMO_c0479	COG0277	FAD linked oxidase domain protein
TMO_c0480	COG0277	FAD linked oxidase domain protein
TMO_c0484	COG0318	PFAM AMP-dependent synthetase and ligase
TMO_c0485	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
TMO_c0486	COG3239	Fatty acid desaturase
TMO_c0490	COG0644	oxidoreductase
TMO_c0492	COG1012	belongs to the aldehyde dehydrogenase family
TMO_c0496	COG4453	Protein conserved in bacteria
TMO_c0498	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
TMO_c0499	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
TMO_c0504	COG1760	l-serine dehydratase
TMO_c0505	COG1473	amidohydrolase
TMO_c0506	COG0583	DNA-binding transcription factor activity
TMO_c0510	COG0840	transmembrane signaling receptor activity
TMO_c0511	COG0840	transmembrane signaling receptor activity
TMO_c0517	COG1518	maintenance of DNA repeat elements
TMO_c0520	COG1653	transport
TMO_c0526	COG1301	dicarboxylic acid transport
TMO_c0527	COG4191	Histidine kinase
TMO_c0528	COG2204	response regulator
TMO_c0530	COG3706	GGDEF domain
TMO_c0531	COG3033	Beta-eliminating lyase
TMO_c0533	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
TMO_c0535	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
TMO_c0537	COG1028	Short-chain dehydrogenase reductase Sdr
TMO_c0538	COG0583	DNA-binding transcription factor activity
TMO_c0542	COG2910	NAD(P)H-binding
TMO_c0543	COG1733	regulation of RNA biosynthetic process
TMO_c0545	COG2249	NAD(P)H dehydrogenase (quinone) activity
TMO_c0547	COG0500	methyltransferase
TMO_c0549	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
TMO_c0550	COG4221	oxidoreductase activity
TMO_c0556	COG2822	iron ion transport
TMO_c0561	COG2205	protein histidine kinase activity
TMO_c0561	COG2202	Pas domain
TMO_c0573	COG0477	Major facilitator Superfamily
TMO_c0586	COG0482	sulfurtransferase activity
TMO_c0587	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
TMO_c0589	COG0316	Belongs to the HesB IscA family
TMO_c0590	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
TMO_c0591	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
TMO_c0592	COG4651	solute:proton antiporter activity
TMO_c0592	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
TMO_c0600	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
TMO_c0603	COG0300	oxidoreductase activity
TMO_c0603	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
TMO_c0603	COG1028	Short-chain dehydrogenase reductase Sdr
TMO_c0603	COG3321	synthase
TMO_c0603	COG0318	PFAM AMP-dependent synthetase and ligase
TMO_c0607	COG1028	Short-chain dehydrogenase reductase Sdr
TMO_c0607	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
TMO_c0607	COG0318	PFAM AMP-dependent synthetase and ligase
TMO_c0607	COG0300	oxidoreductase activity
TMO_c0607	COG3321	synthase
TMO_c0608	COG1028	Short-chain dehydrogenase reductase Sdr
TMO_c0608	COG4221	oxidoreductase activity
TMO_c0608	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
TMO_c0608	COG3321	synthase
TMO_c0619	COG2807	transmembrane transport
TMO_c0620	COG2186	Transcriptional regulator
TMO_c0622	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
TMO_c0623	COG1845	cytochrome c oxidase, subunit III
TMO_c0624	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
TMO_c0625	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
TMO_c0631	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
TMO_c0633	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
TMO_c0635	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
TMO_c0636	COG0366	Alpha amylase catalytic
TMO_c0639	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
TMO_c0641	COG1024	Enoyl-CoA hydratase
TMO_c0643	COG0277	FAD linked oxidase domain protein
TMO_c0645	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
TMO_c0649	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
TMO_c0655	COG1028	Short-chain dehydrogenase reductase Sdr
TMO_c0660	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
TMO_c0661	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
TMO_c0664	COG3620	sequence-specific DNA binding
TMO_c0665	COG1104	cysteine desulfurase activity
TMO_c0666	COG1104	cysteine desulfurase activity
TMO_c0667	COG1959	2 iron, 2 sulfur cluster binding
TMO_c0668	COG1045	serine acetyltransferase
TMO_c0669	COG2945	thiolester hydrolase activity
TMO_c0670	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
TMO_c0676	COG0789	Transcriptional regulator
TMO_c0678	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
TMO_c0680	COG2353	YceI-like domain
TMO_c0685	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
TMO_c0686	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
TMO_c0687	COG2833	Protein of unknown function (DUF455)
TMO_c0694	COG1012	belongs to the aldehyde dehydrogenase family
TMO_c0694	COG2030	dehydratase
TMO_c0695	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
TMO_c0697	COG2197	response regulator
TMO_c0698	COG3916	Acyl-homoserine-lactone synthase
TMO_c0703	COG0860	N-Acetylmuramoyl-L-alanine amidase
TMO_c0704	COG1530	ribonuclease E activity
TMO_c0705	COG0436	Aminotransferase
TMO_c0709	COG0546	phosphoglycolate phosphatase activity
TMO_c0717	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
TMO_c0720	COG0840	transmembrane signaling receptor activity
TMO_c0726	COG0667	Aldo Keto reductase
TMO_c0731	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
TMO_c0732	COG0511	ligase activity, forming carbon-carbon bonds
TMO_c0733	COG0439	Biotin carboxylase
TMO_c0735	COG3106	COG3106 Predicted ATPase
TMO_c0737	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
TMO_c0741	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
TMO_c0751	COG0559	Belongs to the binding-protein-dependent transport system permease family
TMO_c0753	COG2814	Major facilitator Superfamily
TMO_c0754	COG0583	DNA-binding transcription factor activity
TMO_c0758	COG1690	Belongs to the RtcB family
TMO_c0759	COG4650	regulator
TMO_c0760	COG1959	2 iron, 2 sulfur cluster binding
TMO_c0766	COG1022	Amp-dependent synthetase and ligase
TMO_c0770	COG0559	Belongs to the binding-protein-dependent transport system permease family
TMO_c0773	COG1960	acyl-CoA dehydrogenase activity
TMO_c0777	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
TMO_c0782	COG1960	acyl-CoA dehydrogenase activity
TMO_c0783	COG1250	3-hydroxyacyl-CoA dehydrogenase
TMO_c0783	COG1024	Enoyl-CoA hydratase
TMO_c0784	COG0183	Belongs to the thiolase family
TMO_c0786	COG0318	PFAM AMP-dependent synthetase and ligase
TMO_c0792	COG1703	isobutyryl-CoA mutase activity
TMO_c0793	COG0574	Belongs to the PEP-utilizing enzyme family
TMO_c0793	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
TMO_c0796	COG0752	glycyl-tRNA synthetase alpha subunit
TMO_c0799	COG2890	protein-(glutamine-N5) methyltransferase activity
TMO_c0801	COG0142	geranyltranstransferase activity
TMO_c0802	COG2202	Pas domain
TMO_c0802	COG2205	protein histidine kinase activity
TMO_c0806	COG0318	PFAM AMP-dependent synthetase and ligase
TMO_c0807	COG1960	acyl-CoA dehydrogenase activity
TMO_c0808	COG1024	Enoyl-CoA hydratase
TMO_c0813	COG1309	transcriptional regulator
TMO_c0819	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
TMO_c0822	COG0493	'glutamate synthase
TMO_c0824	COG0439	Biotin carboxylase
TMO_c0827	COG1881	PFAM PEBP family protein
TMO_c0830	COG1280	lysine exporter protein (LysE YggA)
TMO_c0836	COG4771	TonB-dependent receptor
TMO_c0837	COG4178	(ABC) transporter
TMO_c0838	COG0667	Aldo Keto reductase
TMO_c0842	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
TMO_c0843	COG0778	Nitroreductase
TMO_c0845	COG2205	protein histidine kinase activity
TMO_c0845	COG2202	Pas domain
TMO_c0848	COG1573	uracil-dna glycosylase
TMO_c0849	COG3284	Transcriptional regulator
TMO_c0850	COG3199	ATP-NAD kinase
TMO_c0851	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
TMO_c0852	COG0022	dehydrogenase e1 component
TMO_c0853	COG0596	Alpha beta hydrolase
TMO_c0853	COG0508	dehydrogenase complex catalyzes the overall conversion of
TMO_c0856	COG2850	peptidyl-arginine hydroxylation
TMO_c0866	COG4774	siderophore transport
TMO_c0867	COG1309	transcriptional regulator
TMO_c0869	COG1024	Enoyl-CoA hydratase
TMO_c0870	COG0183	Belongs to the thiolase family
TMO_c0871	COG2130	NADP-dependent
TMO_c0872	COG2202	Pas domain
TMO_c0872	COG2205	protein histidine kinase activity
TMO_c0876	COG0179	Fumarylacetoacetate (FAA) hydrolase
TMO_c0877	COG4943	cyclic-guanylate-specific phosphodiesterase activity
TMO_c0879	COG1396	sequence-specific DNA binding
TMO_c0880	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
TMO_c0881	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
TMO_c0882	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
TMO_c0884	COG5001	Diguanylate cyclase
TMO_c0884	COG3300	MHYT domain
TMO_c0885	COG1956	GAF domain-containing protein
TMO_c0887	COG0583	DNA-binding transcription factor activity
TMO_c0888	COG2814	Major facilitator Superfamily
TMO_c0889	COG1846	Transcriptional regulator
TMO_c0891	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
TMO_c0892	COG0022	dehydrogenase e1 component
TMO_c0903	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
TMO_c0907	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
TMO_c0910	COG2860	membrane
TMO_c0913	COG1028	Short-chain dehydrogenase reductase Sdr
TMO_c0914	COG1028	Short-chain dehydrogenase reductase Sdr
TMO_c0915	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
TMO_c0917	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
TMO_c0919	COG2217	Heavy metal translocating P-type atpase
TMO_c0921	COG0348	domain, Protein
TMO_c0922	COG2010	Cytochrome c
TMO_c0924	COG3278	Belongs to the heme-copper respiratory oxidase family
TMO_c0928	COG0410	ABC transporter
TMO_c0931	COG0559	Belongs to the binding-protein-dependent transport system permease family
TMO_c0934	COG2119	membrane
TMO_c0936	COG0189	ligase activity
TMO_c0938	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
TMO_c0941	COG0318	PFAM AMP-dependent synthetase and ligase
TMO_d0007	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
TMO_d0008	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
TMO_d0009	COG0154	amidase activity
TMO_d0010	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
TMO_d0017	COG2011	ABC-type metal ion transport system permease component
TMO_d0018	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
TMO_d0019	COG0602	queuosine metabolic process
TMO_d0021	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
TMO_d0024	COG1309	transcriptional regulator
TMO_d0027	COG1349	DNA-binding transcription factor activity
TMO_d0029	COG3842	ATPase activity
TMO_d0035	COG1349	DNA-binding transcription factor activity
TMO_d0038	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
TMO_d0042	COG1396	sequence-specific DNA binding
TMO_d0043	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
TMO_d0044	COG0765	amino acid transport
TMO_d0045	COG1126	abc transporter atp-binding protein
TMO_d0046	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
TMO_d0048	COG1120	ATPase activity
TMO_d0053	COG4774	siderophore transport
TMO_d0059	COG0330	HflC and HflK could
TMO_d0060	COG0330	HflC and HflK could
TMO_d0064	COG0667	Aldo Keto reductase
TMO_d0065	COG0560	Phosphoserine phosphatase
TMO_d0066	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
TMO_d0067	COG0028	Belongs to the TPP enzyme family
TMO_d0068	COG0440	acetolactate synthase activity
TMO_d0069	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
TMO_d0070	COG1295	ribonuclease BN