locus-tag	class	description
Tola_0001	ENOG4105CI4	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity)
Tola_0002	ENOG4105CZ8	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity)
Tola_0003	ENOG4105C3X	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity)
Tola_0004	ENOG4105C7D	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
Tola_0005	ENOG4107XW0	Spermidine putrescine ABC transporter periplasmic spermidine putrescine-binding protein
Tola_0006	ENOG4105BZU	Histidine kinase
Tola_0007	ENOG4105JKW	Valine--pyruvate aminotransferase
Tola_0008	ENOG4105C38	Glycyl-tRNA synthetase beta subunit
Tola_0009	ENOG4107QIB	glycyl-tRNA synthetase, alpha subunit
Tola_0010	ENOG4108R3E	Dna-3-methyladenine glycosylase i
Tola_0012	ENOG4105DE7	Sulfate ABC transporter periplasmic sulfate-binding protein
Tola_0014	ENOG4108I5D	sulfate abc transporter
Tola_0015	ENOG4105ECW	sulfate abc transporter
Tola_0016	ENOG4108IJ6	ABC transporter
Tola_0017	ENOG4107R11	Transcriptional regulator
Tola_0018	ENOG41082K8	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Interacts with IscS and stimulates its activity. Then, accepts a sulfur from IscS and transfers it in turn to TusD (By similarity)
Tola_0019	ENOG4108JP0	extracellular solute-binding protein family 1
Tola_0020	ENOG4105E0F	Histidine kinase
Tola_0021	ENOG4105DPZ	Two component transcriptional regulator (Winged helix family
Tola_0022	ENOG4108RR8	protoporphyrinogen oxidase
Tola_0024	ENOG4105DQ6	Transposase
Tola_0027	ENOG4105E2K	Glycosyl transferase (Group 1
Tola_0028	ENOG4106WTF	Glycosyl transferase, family 2
Tola_0029	ENOG4105DKP	glycosyl transferase, family 9
Tola_0030	ENOG4105XA0	heptosyltransferase ii
Tola_0031	ENOG4105PF3	O-Antigen polymerase
Tola_0032	ENOG4105CUI	Catalyzes the interconversion between ADP-D-glycero- beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose (By similarity)
Tola_0034	ENOG4107W52	maltose operon periplasmic protein
Tola_0037	ENOG4107FKK	extracellular solute-binding protein family 1
Tola_0038	ENOG4105D56	permease protein
Tola_0039	ENOG4105EG2	ABC transporter, permease
Tola_0042	ENOG4105E8R	UPF0173 metal-dependent hydrolase
Tola_0043	ENOG4107RTM	4-alpha-glucanotransferase (EC 2.4.1.25)
Tola_0044	ENOG4107QQN	Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity)
Tola_0045	ENOG41061ZR	Transcriptional regulator
Tola_0046	ENOG4105DKQ	ROK family
Tola_0047	ENOG4105DPZ	Two component transcriptional regulator (Winged helix family
Tola_0049	ENOG4105D2N	Aldolase
Tola_0051	ENOG4105CMG	Carbohydrate kinase
Tola_0052	ENOG4105E9V	Periplasmic binding protein LacI transcriptional regulator
Tola_0053	ENOG4105CNN	ABC, transporter
Tola_0054	ENOG4105C2J	ABC transporter
Tola_0057	ENOG4107N1Q	ErfK YbiS YcfS YnhG family protein
Tola_0058	ENOG4105DSY	exodeoxyribonuclease V, gamma
Tola_0059	ENOG4107QKA	exodeoxyribonuclease V beta
Tola_0060	ENOG4107QYX	exodeoxyribonuclease v alpha
Tola_0061	ENOG4105SYT	Methylenetetrahydrofolate reductase
Tola_0062	ENOG4105C1I	TRANSCRIPTIONAl REGULATOR GntR family
Tola_0064	ENOG4105C1J	atp-dependent rna helicase
Tola_0065	ENOG4105C1J	atp-dependent rna helicase
Tola_0066	ENOG4105E98	transcriptional regulator DeoR family
Tola_0067	ENOG4105C6V	Glycerol-3-phosphate dehydrogenase
Tola_0068	ENOG4108JQ0	Key enzyme in the regulation of glycerol uptake and metabolism (By similarity)
Tola_0071	ENOG4107VXZ	Hydrolase
Tola_0072	ENOG4105CS6	Rhs element vgr protein
Tola_0077	ENOG4105CKI	cobalamin synthesis protein
Tola_0079	ENOG4108M6U	Universal stress protein A
Tola_0081	ENOG4108K2R	Glutathione-regulated potassium-efflux system ancillary protein
Tola_0082	ENOG4105CUG	Oligopeptidase b
Tola_0084	ENOG4105CS1	NAD(P)H quinone oxidoreductase
Tola_0087	ENOG41087YS	Phage shock protein A
Tola_0088	ENOG4105E51	psp operon transcriptional activator
Tola_0089	ENOG4105VVZ	metal-binding protein
Tola_0090	ENOG41061N2	exported protein
Tola_0091	ENOG41076UM	multiple antibiotic resistance (MarC)-related protein
Tola_0092	ENOG4105CCA	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle (By similarity)
Tola_0094	ENOG4105C0N	N-acetylglutamate semialdehyde dehydrogenase
Tola_0095	ENOG4105CAS	nag kinase
Tola_0097	ENOG4105CH7	arginosuccinase
Tola_0098	ENOG4108Z10	Involved in the binding of tRNA to the ribosomes (By similarity)
Tola_0099	ENOG4105EEE	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity)
Tola_0100	ENOG4106U5A	One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity)
Tola_0101	ENOG41080KG	One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity)
Tola_0102	ENOG4105CFD	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
Tola_0103	ENOG4105K7S	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity)
Tola_0104	ENOG4105KAP	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity)
Tola_0105	ENOG4105CKE	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity)
Tola_0106	ENOG4108R70	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity)
Tola_0107	ENOG41083MP	50s ribosomal protein l29
Tola_0108	ENOG4105K87	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal
Tola_0109	ENOG4108UNN	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity)
Tola_0110	ENOG4105KAR	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity)
Tola_0111	ENOG4105CW6	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
Tola_0112	ENOG4105VBI	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity)
Tola_0113	ENOG4108UJY	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity)
Tola_0114	ENOG4108R5J	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity)
Tola_0115	ENOG4105K4C	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity)
Tola_0116	ENOG4108RA9	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity)
Tola_0117	ENOG4105VPB	50S ribosomal protein L30
Tola_0118	ENOG4108UZ0	Binds to the 23S rRNA (By similarity)
Tola_0119	ENOG4105CGG	The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity)
Tola_0120	ENOG41067V7	50S ribosomal protein L36
Tola_0121	ENOG4108Z04	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
Tola_0122	ENOG4108UHH	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity)
Tola_0123	ENOG4105G6W	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity)
Tola_0124	ENOG4105CTF	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
Tola_0125	ENOG4108ZT0	50S ribosomal protein l17
Tola_0127	ENOG4105GGQ	This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis (By similarity)
Tola_0128	ENOG4105C28	cystathionine
Tola_0129	ENOG4105CFH	Aspartokinase
Tola_0130	ENOG4105VSY	K01512 acylphosphatase EC 3.6.1.7
Tola_0131	ENOG4105ERD	Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity)
Tola_0132	ENOG4108ZEF	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity)
Tola_0136	ENOG4105D8A	3-Deoxy-D-manno-octulosonic-acid transferase
Tola_0137	ENOG4105CP9	extracellular ligand-binding receptor
Tola_0138	ENOG4105C32	Amino acid ABC transporter (Permease)
Tola_0139	ENOG4105CF8	branched-chain amino acid ABC transporter, permease
Tola_0140	ENOG4105C0Z	ABC transporter
Tola_0141	ENOG4108IV0	ABC, transporter
Tola_0142	ENOG4105M78	Catalyzes, although with low efficiency, the sulfur transfer reaction from thiosulfate to cyanide (By similarity)
Tola_0144	ENOG4105VEI	Removes the pyruvyl group from chorismate, with concomitant aromatization of the ring, to provide 4- hydroxybenzoate (4HB) for the ubiquinone pathway (By similarity)
Tola_0145	ENOG4105C4G	Synthesis of 3-octaprenyl-4-hydroxybenzoate (By similarity)
Tola_0146	ENOG4105DS7	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity)
Tola_0147	ENOG4108UIQ	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity)
Tola_0148	ENOG4105KPV	Transcriptional regulator
Tola_0149	ENOG4105D37	Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA (By similarity)
Tola_0150	ENOG4105C1A	potassium transporter peripheral membrane
Tola_0151	ENOG4105CYJ	ribosomal RNA small subunit methyltransferase B
Tola_0152	ENOG4105CAE	Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity)
Tola_0153	ENOG4108Z02	Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity)
Tola_0154	ENOG4108WZM	domain protein
Tola_0155	ENOG4105C79	DNA protecting protein DprA
Tola_0156	ENOG4108RPN	Protein smg homolog
Tola_0157	ENOG4108WI1	Dna topoisomerase
Tola_0158	ENOG4108UM6	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity)
Tola_0159	ENOG4105EK0	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity)
Tola_0160	ENOG4105E2X	shikimate dehydrogenase
Tola_0161	ENOG4108Z0R	Transferase
Tola_0162	ENOG4105E46	N-alpha,N-alpha,N-alpha-trimethyl-L-histidine metabolic process
Tola_0164	ENOG4105CG3	alpha amylase, catalytic region
Tola_0165	ENOG4105C5Y	PTS System
Tola_0166	ENOG4105D4X	repressor
Tola_0167	ENOG4108R66	Conserved Protein
Tola_0169	ENOG4108IQK	o-acetylhomoserine
Tola_0170	ENOG4105C0R	drug resistance transporter emrb qaca subfamily
Tola_0171	ENOG4105DRP	amino acid AbC transporter
Tola_0172	ENOG4105EAB	amino acid AbC transporter
Tola_0174	ENOG4105C3R	Methionine synthase
Tola_0175	ENOG4105KQ5	peptidylprolyl cis-trans isomerase
Tola_0177	ENOG4105DQF	Hydrolase
Tola_0178	ENOG4105CWR	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity)
Tola_0179	ENOG4105VFG	Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity)
Tola_0181	ENOG4105W0E	50S ribosomal protein L33
Tola_0182	ENOG4105KDC	50s ribosomal protein l28
Tola_0183	ENOG4105W5Q	DNA repair protein (RadC
Tola_0184	ENOG4105CJS	Phosphopantothenoylcysteine decarboxylase
Tola_0185	ENOG4108Z1K	This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity)
Tola_0186	ENOG4107QP2	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity)
Tola_0187	ENOG4105ED0	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity)
Tola_0188	ENOG4105DSJ	YicC domain protein
Tola_0189	ENOG4105CK2	sodium dicarboxylate symporter
Tola_0190	ENOG4105BZU	Histidine kinase
Tola_0191	ENOG4108Z66	YbaK ebsC protein
Tola_0192	ENOG4105NBK	UPF0345 protein
Tola_0199	ENOG4105C2Z	ATP-dependent CLP protease ATP-binding subunit
Tola_0200	ENOG4108JUA	Transcriptional regulator
Tola_0208	ENOG4105D9P	serine threonine protein kinase
Tola_0209	ENOG4105CS6	Rhs element vgr protein
Tola_0210	ENOG4105D9M	gamma-glutamylcysteine synthetase
Tola_0211	ENOG4105CYM	Glutathione S-transferase
Tola_0214	ENOG4105CEQ	signal transduction histidine kinase regulating citrate malate metabolism
Tola_0215	ENOG4108MRH	transcriptional regulatory protein
Tola_0216	ENOG4105BZU	Histidine kinase
Tola_0217	ENOG4105DWF	phosphomethylpyrimidine kinase
Tola_0218	ENOG4108UV6	Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity)
Tola_0219	ENOG4105C4U	4-methyl-5-beta-hydroxyethylthiazole kinase
Tola_0221	ENOG4105E2R	ROK family
Tola_0223	ENOG4105CPQ	Dehydrogenase
Tola_0224	ENOG4105CHR	reductase
Tola_0225	ENOG4105C6Z	Gluconate
Tola_0226	ENOG4105K2J	Transcriptional regulator
Tola_0227	ENOG4108Z67	carbohydrate kinase, thermoresistant glucokinase family
Tola_0228	ENOG4105C01	Dihydroxy-acid dehydratase
Tola_0229	ENOG4108UHU	Aldolase
Tola_0231	ENOG4105C5U	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity)
Tola_0232	ENOG4105CPF	Cell wall formation (By similarity)
Tola_0234	ENOG4106UX7	integral membrane protein
Tola_0235	ENOG4105DFC	had-superfamily hydrolase, subfamily ia, variant
Tola_0236	ENOG4105SKE	transcriptional Regulator LysR family
Tola_0237	ENOG4105E5M	Multidrug resistance protein D
Tola_0238	ENOG4108YYA	Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity)
Tola_0241	ENOG4105CB5	ATP-dependent DNA helicase recG
Tola_0242	ENOG410787A	Pts system, glucitol sorbitol-specific
Tola_0243	ENOG4105DZY	Pts system, glucitol sorbitol-specific
Tola_0244	ENOG4105VI0	Pts system, glucitol sorbitol-specific
Tola_0245	ENOG4107QMF	Sorbitol-6-phosphate dehydrogenase
Tola_0247	ENOG410804X	Transcriptional regulator
Tola_0248	ENOG4105K56	Transcriptional regulator
Tola_0249	ENOG4105D01	(LipO)protein
Tola_0250	ENOG4108UMI	ABC transporter, permease
Tola_0251	ENOG4108JEI	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity)
Tola_0253	ENOG4105DFF	Rod shape-determining protein mreb
Tola_0254	ENOG4105N3I	Involved in formation and maintenance of cell shape (By similarity)
Tola_0255	ENOG4105VQ7	Rod shape-determining protein MreD
Tola_0257	ENOG4105C03	ribonuclease
Tola_0258	ENOG4105QD6	exported protein
Tola_0260	ENOG4105D1U	peptidase U62 modulator of DNA gyrase
Tola_0261	ENOG4105N42	UPF0307 protein
Tola_0262	ENOG4105CMS	peptidase U62, modulator of DNA gyrase
Tola_0263	ENOG41090HJ	UPF0265 protein
Tola_0265	ENOG4105C4R	Atp-dependent dna helicase
Tola_0268	ENOG4105C9B	Cysteine desulfurase
Tola_0269	ENOG4105P9C	Participates in cysteine desulfuration mediated by SufS. Cysteine desulfuration mobilizes sulfur from L-cysteine to yield L-alanine and constitutes an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules. Functions as a sulfur acceptor for SufS, by mediating the direct transfer of the sulfur atom from the S-sulfanylcysteine of SufS, an intermediate product of cysteine desulfuration process (By similarity)
Tola_0271	ENOG4105CUZ	uba thif-type nad fad binding protein
Tola_0272	ENOG4105CKK	Glycosyl transferase, family 2
Tola_0274	ENOG4105SA9	Catalyzes the transfer of the L-Ara4N moiety of the glycolipid undecaprenyl phosphate-alpha-L-Ara4N to lipid A. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides (By similarity)
Tola_0277	ENOG4105DY2	Paraquat-inducible protein b
Tola_0278	ENOG4105F1S	paraquat-inducible protein a
Tola_0279	ENOG4105C6M	Alpha-keto-beta-hydroxylacyl reductoisomerase
Tola_0280	ENOG4105EMY	transcriptional regulator
Tola_0281	ENOG4107QP8	phosphohexose isomerase
Tola_0282	ENOG4105BZU	Histidine kinase
Tola_0283	ENOG4105CTS	PTS system mannitol-specific
Tola_0284	ENOG4107SQ3	mannitol-1-phosphate 5-dehydrogenase
Tola_0285	ENOG4105E61	Mannitol repressor protein
Tola_0286	ENOG4105DM4	PTS System
Tola_0287	ENOG4105DE4	1-phosphofructokinase
Tola_0288	ENOG4105DTZ	bifunctional PTS system fructose-specific transporter subunit IIA HPr protein
Tola_0289	ENOG4107B7Y	DNA-binding transcriptional regulator FruR
Tola_0291	ENOG4105UQX	Mate efflux family protein
Tola_0292	ENOG4105ENJ	RND efflux system, outer membrane lipoprotein
Tola_0294	ENOG4105DJY	efflux transporter, rnd family, mfp subunit
Tola_0295	ENOG4108594	Permease of the drug metabolite transporter
Tola_0296	ENOG4105CGB	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system (By similarity)
Tola_0297	ENOG4105E0C	molybdate abc transporter
Tola_0298	ENOG4105F4R	Transcriptional regulator mode
Tola_0299	ENOG4105VJY	transcriptional regulator
Tola_0300	ENOG4105CAJ	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity)
Tola_0301	ENOG410804X	Transcriptional regulator
Tola_0302	ENOG4105C46	Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity)
Tola_0308	ENOG4105VYW	UPF0251 protein
Tola_0311	ENOG410635M	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein (By similarity)
Tola_0312	ENOG41090R7	Ferric uptake
Tola_0315	ENOG4105D3R	alkyl hydroperoxide reductase
Tola_0324	ENOG4105HMI	Membrane
Tola_0326	ENOG4108K4B	hydrolase
Tola_0327	ENOG4105DWR	Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity)
Tola_0330	ENOG4105D52	delta-aminolevulinic acid dehydratase
Tola_0331	ENOG4105CNK	Required, probably indirectly, for the hydroxylation of 2-octaprenylphenol to 2-octaprenyl-6-hydroxy-phenol, the fourth step in ubiquinone biosynthesis (By similarity)
Tola_0332	ENOG4105JC1	sterol-binding domain protein
Tola_0333	ENOG4105DDZ	Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity)
Tola_0335	ENOG4105EX9	Membrane
Tola_0336	ENOG4105C2M	dna polymerase I
Tola_0337	ENOG4105WHM	Necessary for normal cell division and for the maintenance of normal septation (By similarity)
Tola_0342	ENOG4108WC9	type VI secretion system effector, hcp1 family
Tola_0344	ENOG4107QV7	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system) (By similarity)
Tola_0347	ENOG4105D0M	Protease HtpX homolog
Tola_0348	ENOG4108V0P	LemA family
Tola_0349	ENOG4105C4R	Atp-dependent dna helicase
Tola_0350	ENOG4105DFH	Transport of potassium into the cell (By similarity)
Tola_0352	ENOG4105ENJ	RND efflux system, outer membrane lipoprotein
Tola_0353	ENOG4105BZS	acriflavin resistance protein
Tola_0354	ENOG4105C1P	efflux transporter, rnd family, mfp subunit
Tola_0355	ENOG4105XEA	Tetr family transcriptional regulator
Tola_0356	ENOG4105BZU	Histidine kinase
Tola_0357	ENOG4105PIC	general secretion pathway protein N
Tola_0364	ENOG4108VAU	general secretion pathway protein G
Tola_0365	ENOG4105D7Q	type ii secretion system
Tola_0366	ENOG4107QHF	type ii secretion system protein e
Tola_0371	ENOG4107RK2	ADP-ribose diphosphatase NudE
Tola_0374	ENOG4105CXD	Specific inhibitor of chromosomal initiation of replication in vitro. Binds the three 13-mers in the origin (oriC) to block initiation of replication (By similarity)
Tola_0377	ENOG4107R9T	Catalyzes the formation of 5-methyl-uridine at position 54 (m5U54) in all tRNAs (By similarity)
Tola_0378	ENOG4105CHI	Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB (By similarity)
Tola_0379	ENOG4105DP5	Catalyzes the biosynthesis of agmatine from arginine (By similarity)
Tola_0380	ENOG4105C8P	)-transporter
Tola_0381	ENOG4108RDD	Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine (By similarity)
Tola_0382	ENOG4108UHE	carbonic anhydrase
Tola_0383	ENOG4105D1S	lipid A biosynthesis
Tola_0384	ENOG4105DW0	Catalyzes the ADP transfer to D-glycero-D-manno-heptose 1-phosphate, yielding ADP-D,D-heptose (By similarity)
Tola_0385	ENOG4105E3J	oxidoreductase
Tola_0386	ENOG4108NKP	c4-dicarboxylate transporter malic acid transport protein
Tola_0387	ENOG4105DFG	type I secretion outer membrane protein
Tola_0388	ENOG4107QWP	ABC-2 type transporter
Tola_0389	ENOG4105CJ1	ABC, transporter
Tola_0390	ENOG4105D0S	secretion protein (HlyD
Tola_0392	ENOG41087AY	ADP-Ribose pyrophosphatase
Tola_0393	ENOG4108SX3	cytoplasmic protein
Tola_0394	ENOG41070EG	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes (By similarity)
Tola_0395	ENOG4105IPS	esterase
Tola_0396	ENOG4105C7D	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
Tola_0398	ENOG4105CHH	sulfate transporter
Tola_0400	ENOG4106AFN	Lyase and sodium transporter (By similarity)
Tola_0401	ENOG4107QSA	Oxaloacetate decarboxylase
Tola_0402	ENOG4105D9Q	decarboxylase (Beta subunit)
Tola_0404	ENOG4108KTG	Membrane protein, drug metabolite transporter
Tola_0406	ENOG4105CHG	glycolate oxidase (iron-sulfur subunit)
Tola_0407	ENOG4105DE4	1-phosphofructokinase
Tola_0411	ENOG4105DJB	Major Facilitator Superfamily
Tola_0412	ENOG4105EJC	lysr family transcriptional regulator
Tola_0413	ENOG4106DSS	Tartrate dehydratase subunit alpha
Tola_0414	ENOG4107GFK	fumarate
Tola_0415	ENOG4105ERH	Fumarylacetoacetate hydrolase
Tola_0416	ENOG4105DJ1	Phosphoenolpyruvate Carboxylase
Tola_0418	ENOG4105CJD	(Anaerobic) ribonucleoside-triphosphate reductase
Tola_0419	ENOG4105DJ1	Phosphoenolpyruvate Carboxylase
Tola_0420	ENOG4105F4C	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress (By similarity)
Tola_0421	ENOG4105VEJ	Heat shock protein
Tola_0422	ENOG4107MKT	Stringent starvation protein a
Tola_0423	ENOG4105KB2	stringent starvation protein b
Tola_0424	ENOG4105W4M	Transport-associated protein
Tola_0425	ENOG4105F55	Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate (By similarity)
Tola_0426	ENOG41082RQ	UPF0102 protein
Tola_0427	ENOG4105E1C	Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1A (PBP1a) (By similarity)
Tola_0428	ENOG4105CU0	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity)
Tola_0429	ENOG4105CEY	Amp-dependent synthetase and ligase
Tola_0430	ENOG4105DNI	Converts SHCHC to OSB (By similarity)
Tola_0431	ENOG4108IPT	Naphthoate synthase
Tola_0432	ENOG4107J5P	Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro (By similarity)
Tola_0433	ENOG4105C4A	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity)
Tola_0434	ENOG4105E4F	Isochorismate synthase
Tola_0435	ENOG4105EIS	1,4-dihydroxy-2-naphthoate octaprenyltransferase
Tola_0436	ENOG410829K	Lysine exporter protein (Lyse ygga)
Tola_0437	ENOG4105ZR3	A GTPase-activating protein (GAP) that modifies Der EngA GTPase function. May play a role in ribosome biogenesis (By similarity)
Tola_0440	ENOG4105E98	transcriptional regulator DeoR family
Tola_0441	ENOG4105D4P	Coproporphyrinogen iii oxidase
Tola_0442	ENOG4105EJQ	L-serine dehydratase
Tola_0443	ENOG4105DM4	PTS System
Tola_0444	ENOG4108YRF	PTS System
Tola_0445	ENOG4105BZ3	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity)
Tola_0446	ENOG4106R3P	AraC family transcriptional regulator
Tola_0447	ENOG4108XTF	Outer Membrane Lipoprotein
Tola_0448	ENOG4105DKQ	ROK family
Tola_0449	ENOG4105VCP	PTS System
Tola_0450	ENOG4105CS2	ec 3.2.1.21
Tola_0451	ENOG4105CK1	PTS System
Tola_0452	ENOG4105VZJ	PTS System
Tola_0453	ENOG4105CK1	PTS System
Tola_0454	ENOG4105DDV	Transcriptional regulator (LacI family
Tola_0456	ENOG4105C1W	two component, sigma54 specific, transcriptional regulator, Fis family
Tola_0457	ENOG4105CUX	Signal transduction histidine kinase
Tola_0459	ENOG4105C5F	glutamine synthetase
Tola_0461	ENOG4107S2Z	UPF0761 membrane protein
Tola_0463	ENOG4105C24	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
Tola_0464	ENOG4107S7E	1-acyl-sn-glycerol-3-phosphate acyltransferase
Tola_0465	ENOG4105DQR	SNARE associated Golgi
Tola_0466	ENOG4105D8G	Major Facilitator superfamily
Tola_0469	ENOG4105C4N	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis (By similarity)
Tola_0470	ENOG4108R5P	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery (By similarity)
Tola_0471	ENOG41063M6	Cell Division Protein
Tola_0472	ENOG4105C75	arginyL-tRNA synthetase
Tola_0474	ENOG4105K6V	RNA polymerase
Tola_0475	ENOG4108NIX	Factor ChrR
Tola_0479	ENOG4105BZU	Histidine kinase
Tola_0480	ENOG4105C25	Primosomal protein n'
Tola_0481	ENOG4105VFB	Binds the 23S rRNA (By similarity)
Tola_0482	ENOG4105C6K	Malic enzyme
Tola_0483	ENOG4107QE9	Inherit from COG: Membrane
Tola_0484	ENOG4105CBT	Fructose-1,6-bisphosphatase
Tola_0485	ENOG4105U59	-acetyltransferase
Tola_0488	ENOG4105ETT	transcriptional Regulator, LysR family
Tola_0489	ENOG4105EZ6	Catalyzes the 2'-O-methylation at nucleotide C2498 in 23S rRNA (By similarity)
Tola_0490	ENOG4105CIQ	May have a role in processing of nucleic acids. It is probably not an exonuclease
Tola_0491	ENOG4105EWT	decarboxylase family
Tola_0493	ENOG4107R1K	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) (By similarity)
Tola_0494	ENOG4108T6E	Interacts with the SecY protein in vivo. May bind preferentially to an uncomplexed state of SecY, thus functioning either as a chelating agent for excess SecY in the cell or as a regulatory factor that negatively controls the translocase function (By similarity)
Tola_0498	ENOG4105DR9	pseudouridine synthase
Tola_0500	ENOG4107V9H	nitrite transporter
Tola_0501	ENOG4105WZK	nitrite reductase NADPH small subunit
Tola_0502	ENOG4107QZF	nitrite reductase NADPH large subunit
Tola_0503	ENOG4105CJJ	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity)
Tola_0504	ENOG4105EJ7	Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O (By similarity)
Tola_0505	ENOG41063SB	peptidase
Tola_0506	ENOG4105CJI	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity)
Tola_0507	ENOG4107YZP	Rhodanese domain protein
Tola_0508	ENOG4105IX2	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA (By similarity)
Tola_0509	ENOG4105CSF	NADPH-dependent glycerol-3-phosphate dehydrogenase
Tola_0510	ENOG4107RUK	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins (By similarity)
Tola_0512	ENOG4105BZU	Histidine kinase
Tola_0513	ENOG4105D3C	The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity)
Tola_0514	ENOG4105BZM	domain protein
Tola_0515	ENOG4108RRZ	Transcription elongation factor GreB
Tola_0516	ENOG4108V6E	Cell division protein mraZ
Tola_0517	ENOG4105CGJ	Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity)
Tola_0518	ENOG41063Y6	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic (By similarity)
Tola_0519	ENOG4105CJN	penicillin-binding protein
Tola_0520	ENOG4107EEN	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity)
Tola_0521	ENOG4108EQQ	Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein (By similarity)
Tola_0522	ENOG4105CPY	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity)
Tola_0524	ENOG4105CNI	cell division protein FtsW
Tola_0525	ENOG4105DVQ	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity)
Tola_0526	ENOG4105DFU	Cell wall formation (By similarity)
Tola_0527	ENOG4105K7E	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly (By similarity)
Tola_0528	ENOG4105CIT	This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity)
Tola_0529	ENOG4105CDK	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity)
Tola_0530	ENOG4105C7C	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity)
Tola_0532	ENOG4105CI6	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving
Tola_0533	ENOG4105M6F	mutator MutT protein
Tola_0534	ENOG41067SF	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase (By similarity)
Tola_0536	ENOG4105EHH	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue (By similarity)
Tola_0537	ENOG4105D7Q	type ii secretion system
Tola_0538	ENOG4107QHF	type ii secretion system protein e
Tola_0540	ENOG4105C12	Phosphoribosylglycinamide synthetase
Tola_0541	ENOG4105DC1	bifunctional purine biosynthesis protein purh
Tola_0544	ENOG4105K4U	addiction module toxin, RelE StbE family
Tola_0545	ENOG4105EW9	transcriptional regulator AsnC family
Tola_0547	ENOG4105C5H	ABC transporter
Tola_0549	ENOG4108K5H	permease YjgP YjgQ family protein
Tola_0550	ENOG4108M8S	permease YjgP YjgQ family protein
Tola_0551	ENOG4105BZ6	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity)
Tola_0552	ENOG4105MYG	DNA polymerase iii, chi subunit
Tola_0554	ENOG4105HEI	LysR family (Transcriptional regulator
Tola_0555	ENOG4105DS1	cytochrome b561
Tola_0557	ENOG4108YYC	ycei family
Tola_0559	ENOG4105CIN	aminoacyl-histidine dipeptidase
Tola_0560	ENOG4105CJ4	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity)
Tola_0562	ENOG4107S8C	mandelate racemase muconate lactonizing
Tola_0563	ENOG4105F0I	Aminotransferase
Tola_0564	ENOG4105BZG	amino acid carrier protein
Tola_0565	ENOG4105D3R	alkyl hydroperoxide reductase
Tola_0566	ENOG4108JU3	Alkyl hydroperoxide reductase
Tola_0567	ENOG4105VEQ	Cold shock protein
Tola_0568	ENOG4105EST	Metal Dependent Phosphohydrolase
Tola_0569	ENOG4105MRB	Catalyzes the interconversion of beta-pyran and beta- furan forms of D-ribose (By similarity)
Tola_0570	ENOG4108RVA	ribokinase
Tola_0571	ENOG4105MRB	Catalyzes the interconversion of beta-pyran and beta- furan forms of D-ribose (By similarity)
Tola_0573	ENOG4105CNN	ABC, transporter
Tola_0574	ENOG4105E9V	Periplasmic binding protein LacI transcriptional regulator
Tola_0575	ENOG4108RVA	ribokinase
Tola_0576	ENOG4105ETE	Transcriptional regulator (LacI family
Tola_0577	ENOG41065RQ	ADP-ribosylation crystallin J1
Tola_0579	ENOG4105CDM	Glutamate-1-semialdehyde aminotransferase
Tola_0580	ENOG4108YX9	iron--sulfur cluster insertion protein erpA
Tola_0582	ENOG4105ED7	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling (By similarity)
Tola_0583	ENOG4105DA0	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity)
Tola_0586	ENOG4107RH7	Nicotinate phosphoribosyltransferase
Tola_0587	ENOG4105C4K	Nad synthetase
Tola_0589	ENOG4105C59	p-type ATPase
Tola_0590	ENOG4108Z6Z	Transcriptional regulator
Tola_0592	ENOG4105CMI	transporter
Tola_0593	ENOG4105CJ1	ABC, transporter
Tola_0594	ENOG4105D0S	secretion protein (HlyD
Tola_0597	ENOG4105CQB	FAD linked oxidase domain protein
Tola_0598	ENOG4105KA0	thioesterase Superfamily protein
Tola_0601	ENOG4108S7T	Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP) (By similarity)
Tola_0602	ENOG4105EGS	Mechanosensitive ion channel
Tola_0603	ENOG4105CA9	Pyruvate kinase
Tola_0606	ENOG4105PS4	nifq family
Tola_0607	ENOG4108NIW	Leucine export protein LeuE
Tola_0608	ENOG4105CWM	branched-chain amino acid transport system II carrier protein
Tola_0611	ENOG4105C7K	acetolactate synthase
Tola_0612	ENOG4108ZP8	Acetolactate synthase small subunit
Tola_0613	ENOG4105EN6	Membrane
Tola_0614	ENOG4105JKQ	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity)
Tola_0615	ENOG4105DUF	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity)
Tola_0616	ENOG4105N5T	Radical SAM Protein
Tola_0617	ENOG4105BZU	Histidine kinase
Tola_0618	ENOG4105C4Q	deoxyguanosinetriphosphate triphosphohydrolase-like protein
Tola_0620	ENOG41065U4	response regulator
Tola_0622	ENOG4105D5I	Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity)
Tola_0623	ENOG4105D98	threonine synthase
Tola_0624	ENOG4105C5Y	PTS System
Tola_0625	ENOG4105BZ3	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity)
Tola_0626	ENOG4105KZ7	phosphocarrier protein hpr
Tola_0627	ENOG4105C6T	cysteine synthase
Tola_0628	ENOG4105DIT	ErfK YbiS YcfS YnhG family protein
Tola_0630	ENOG4107NPY	receptor for the septal ring structure, may anchor it to the inner-membrane (By similarity)
Tola_0631	ENOG4105C77	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity)
Tola_0632	ENOG4108ETH	Formylglycinamide ribotide synthetase
Tola_0633	ENOG4108QBX	(LipO)protein
Tola_0638	ENOG4105CIY	formyltetrahydrofolate deformylase
Tola_0642	ENOG4105JPG	D-isomer specific 2-hydroxyacid dehydrogenase
Tola_0647	ENOG4108V1J	Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity)
Tola_0648	ENOG4107T9C	Alpha amylase catalytic region
Tola_0650	ENOG4105DSM	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex, which has 2 components the iron protein and the molybdenum-iron protein (By similarity)
Tola_0663	ENOG4105UG9	Antitoxin of the YafO-YafN toxin-antitoxin system
Tola_0667	ENOG4108IAB	Phoh family
Tola_0668	ENOG4107T0D	ABC, transporter
Tola_0669	ENOG4106SMU	thiamine transporter membrane protein
Tola_0670	ENOG4105DP9	ABC transporter
Tola_0673	ENOG4105CQ0	ABC transporter
Tola_0674	ENOG4108IPW	abc transporter atp-binding protein
Tola_0675	ENOG4105CM4	permease protein
Tola_0676	ENOG4105DHS	permease protein
Tola_0679	ENOG4105MQS	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity)
Tola_0680	ENOG4105CQI	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity)
Tola_0681	ENOG4105C0C	Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity)
Tola_0682	ENOG4105CYQ	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity)
Tola_0683	ENOG4105CNG	UPF0061 protein
Tola_0684	ENOG4107T8T	UPF0173 metal-dependent hydrolase
Tola_0687	ENOG4108W15	Protein of unknown function (DUF1456)
Tola_0688	ENOG4108Z8G	Alkylphosphonate utilization operon protein PhnA
Tola_0689	ENOG4105WQ3	Rna-binding protein
Tola_0690	ENOG4105VYA	Uncharacterized conserved protein (DUF2132)
Tola_0699	ENOG4105DTA	methyltransferase
Tola_0705	ENOG4107RRE	RNA-directed DNA polymerase
Tola_0711	ENOG4105EMK	carboxylate amino acid amine transporter
Tola_0722	ENOG4105K70	DNA-binding protein
Tola_0737	ENOG4108Z6H	mu-like prophage Flumu protein gp27
Tola_0738	ENOG4105CF2	Mu-like prophage FluMu protein GP28
Tola_0739	ENOG4105QIB	mu-like prophage Flumu protein gp29
Tola_0743	ENOG4108TVE	i protein
Tola_0744	ENOG4105EFV	Major head subunit
Tola_0749	ENOG4108NYK	Tape measure protein
Tola_0759	ENOG4105CD3	dihydroorotase
Tola_0761	ENOG4105K59	histidine triad (HIT) protein
Tola_0764	ENOG41080QH	sigma 54 modulation protein ribosomal protein S30EA
Tola_0765	ENOG4107SC1	transglycosylase
Tola_0766	ENOG4108535	NAD dependent epimerase/dehydratase family
Tola_0769	ENOG4105E96	Colicin v production protein
Tola_0770	ENOG4105CBA	glutamine phosphoribosylpyrophosphate amidotransferase
Tola_0771	ENOG41086N6	Is required to sustain N(2)-dependent growth in the presence of low levels of carbon monoxide (CO). Probably acts by protecting the N(2) fixation ability of the nitrogenase complex, which is inactivated in the presence of CO (By similarity)
Tola_0775	ENOG4105DIQ	Transcriptional regulator
Tola_0776	ENOG4108UHU	Aldolase
Tola_0777	ENOG4105C01	Dihydroxy-acid dehydratase
Tola_0778	ENOG4108Z67	carbohydrate kinase, thermoresistant glucokinase family
Tola_0779	ENOG4105C6Z	Gluconate
Tola_0781	ENOG4105EE5	Membrane protein terC
Tola_0786	ENOG4105PFA	Catalyzes the conversion of 5-hydroxyuridine (ho5U) to 5-methoxyuridine (mo5U) at position 34 in tRNA (By similarity)
Tola_0787	ENOG4105DA6	Catalyzes the conversion of 5-methoxyuridine (mo5U) to uridine-5-oxyacetic acid (cmo5U) at position 34 in tRNA. May also participate in the methylation of uridine-5-oxyacetic acid (cmo5U) to uridine-5-oxyacetic acid methyl ester (mcmo5U) (By similarity)
Tola_0788	ENOG4105EAK	ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family
Tola_0789	ENOG4105DUM	transcriptional regulator, lysR family
Tola_0790	ENOG4108K3A	Glutathione S-transferase
Tola_0791	ENOG4105CQ7	ATP-dependent helicase
Tola_0792	ENOG4105BZ4	penicillin-binding protein
Tola_0793	ENOG4107S0N	DJ-1 family
Tola_0794	ENOG4108JZF	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity)
Tola_0795	ENOG4108VPT	UPF0234 protein
Tola_0796	ENOG4105EYM	Major Facilitator superfamily
Tola_0797	ENOG4108R5K	PPIases accelerate the folding of proteins (By similarity)
Tola_0799	ENOG4105D8J	Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle (By similarity)
Tola_0801	ENOG4105M85	Bola protein
Tola_0803	ENOG4107RGM	aldo keto reductase
Tola_0804	ENOG4105CQ3	Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity)
Tola_0805	ENOG4105CIN	aminoacyl-histidine dipeptidase
Tola_0807	ENOG4105CGH	5'-nucleotidase
Tola_0808	ENOG4105DYA	Acts on guanine, xanthine and to a lesser extent hypoxanthine (By similarity)
Tola_0809	ENOG4105V1F	Fermentation respiration switch protein
Tola_0811	ENOG4105C2S	Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity)
Tola_0812	ENOG4108UGV	hypoxanthine phosphoribosyltransferase
Tola_0813	ENOG4105WBN	Transcriptional regulator (LacI family
Tola_0816	ENOG4105DA5	(ABC) transporter
Tola_0817	ENOG4105E3A	(ABC) transporter
Tola_0818	ENOG4105C5T	Phosphoribosyl pyrophosphate synthase
Tola_0819	ENOG4105CTR	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity)
Tola_0820	ENOG4105C1U	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein (By similarity)
Tola_0821	ENOG4105C7E	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity)
Tola_0822	ENOG4105C8K	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity)
Tola_0823	ENOG4105EQY	Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity)
Tola_0824	ENOG41063JG	Transcriptional regulator
Tola_0827	ENOG4105C90	Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity)
Tola_0828	ENOG4107SSZ	Phosphatase
Tola_0830	ENOG4108R96	Methyltransferase, YaeB family
Tola_0832	ENOG4108JJ8	(ABC) transporter
Tola_0833	ENOG4108JJ9	ABC, transporter
Tola_0836	ENOG4105CI1	PTS System
Tola_0838	ENOG4105CI1	PTS System
Tola_0839	ENOG4106XY2	Folate-binding protein involved in regulating the level of ATP-DnaA and in the modification of some tRNAs. It is probably a key factor in regulatory networks that act via tRNA modification, such as initiation of chromosomal replication (By similarity)
Tola_0840	ENOG4105Y75	tpr repeat protein
Tola_0842	ENOG4108IYU	L-aspartate oxidase
Tola_0843	ENOG4105EMN	RNA polymerase sigma factor
Tola_0847	ENOG4105C4S	Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity)
Tola_0848	ENOG4105C3F	Signal peptidase i
Tola_0849	ENOG4108ZBM	Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity)
Tola_0851	ENOG41071DT	Involved in DNA repair and RecF pathway recombination (By similarity)
Tola_0854	ENOG4105D6S	protein involved in catabolism of external DNA
Tola_0855	ENOG4105C5H	ABC transporter
Tola_0856	ENOG4108YZY	peptidylprolyl cis-trans isomerase
Tola_0857	ENOG41090R7	Ferric uptake
Tola_0858	ENOG4105MHQ	Low-potential electron donor to a number of redox enzymes (By similarity)
Tola_0859	ENOG4105NNH	LexA regulated protein
Tola_0860	ENOG4105EV9	Alpha Beta Hydrolase
Tola_0861	ENOG4107CDU	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated (By similarity)
Tola_0863	ENOG4108JQ2	peptide transport system atp-binding protein
Tola_0864	ENOG4108JQ3	Peptide ABC transporter ATP-binding protein
Tola_0865	ENOG4108EU3	peptide transport system, permease
Tola_0866	ENOG4108I5W	peptide transport system, permease protein
Tola_0867	ENOG4108J59	Extracellular solute-binding protein, family 5
Tola_0868	ENOG4105CM6	amino acid regulated cytosolic protein
Tola_0869	ENOG4106K28	UPF0283 membrane protein
Tola_0870	ENOG4105E0F	Histidine kinase
Tola_0871	ENOG4105E3W	Two component transcriptional regulator (Winged helix family
Tola_0872	ENOG4108UJV	acyl-CoA thioesterase i
Tola_0873	ENOG4108I0Y	(ABC) transporter
Tola_0874	ENOG4105CV6	ABC transporter, permease
Tola_0877	ENOG4105C6K	Malic enzyme
Tola_0878	ENOG4105C6H	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity)
Tola_0879	ENOG4105PQ6	UPF0208 membrane protein
Tola_0880	ENOG4105F1A	Pyruvate formate-lyase
Tola_0881	ENOG4105C6N	Formate acetyltransferase
Tola_0882	ENOG4105TMB	Formate nitrite transporter
Tola_0883	ENOG4105DDY	UPF0142 protein ycaO
Tola_0884	ENOG4105CM3	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity)
Tola_0885	ENOG4105C55	Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs
Tola_0887	ENOG4105HSZ	Cytoskeletal protein that is involved in cell-shape control through regulation of the length of the long axis (By similarity)
Tola_0889	ENOG4105CUT	histidyl-tRNA synthetase
Tola_0890	ENOG4105N21	Membrane
Tola_0891	ENOG4105CNE	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity)
Tola_0892	ENOG4105DKZ	GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity)
Tola_0894	ENOG4108VKA	Acts as a radical domain for damaged PFL and possibly other radical proteins (By similarity)
Tola_0895	ENOG4105D5S	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity)
Tola_0898	ENOG4108JEH	abc transporter atp-binding protein
Tola_0899	ENOG4105E89	ABC transporter
Tola_0900	ENOG4105DSP	amino acid AbC transporter
Tola_0901	ENOG4106YG3	ABC transporter
Tola_0903	ENOG4105CGK	Exodeoxyribonuclease III
Tola_0904	ENOG4105CTD	carboxy-peptidase
Tola_0907	ENOG4105E1F	short-chain dehydrogenase reductase
Tola_0908	ENOG4105E9H	Lytic Murein transglycosylase
Tola_0909	ENOG4108RW0	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity)
Tola_0910	ENOG4105D1A	Methyltransferase
Tola_0911	ENOG4108UMW	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity)
Tola_0912	ENOG4108JDX	DNA polymerase iii, epsilon subunit
Tola_0913	ENOG4105F55	Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate (By similarity)
Tola_0914	ENOG4105E7A	Glutamine amidotransferase
Tola_0915	ENOG4108V3E	phosphoribosylglycinamide formyltransferase
Tola_0916	ENOG4105CXB	phosphoribosylaminoimidazole synthetase
Tola_0917	ENOG4105CZ5	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity)
Tola_0919	ENOG4105ERG	peptidase m48, ste24p
Tola_0920	ENOG4105C02	permease
Tola_0921	ENOG4107QR8	Thioredoxin
Tola_0923	ENOG4105E68	Sulfatase
Tola_0924	ENOG4105YDX	UPF0352 protein
Tola_0925	ENOG4106V8H	Nucleoid-associated protein
Tola_0926	ENOG4105MK2	5-formyltetrahydrofolate cyclo-ligase
Tola_0929	ENOG4105D0A	hydroxylase
Tola_0930	ENOG4105EAK	ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family
Tola_0933	ENOG4105C1W	two component, sigma54 specific, transcriptional regulator, Fis family
Tola_0934	ENOG4105C3Y	UTP-glucose-1-phosphate uridylyltransferase
Tola_0935	ENOG41083P1	competence protein ComEA helix-hairpin-helix repeat protein
Tola_0936	ENOG4108RNI	3'(2')5'-bisphosphate nucleotidase
Tola_0937	ENOG4105K9H	YciI-like protein
Tola_0938	ENOG4107835	probably involved in intracellular septation (By similarity)
Tola_0939	ENOG4105F6H	The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity)
Tola_0940	ENOG4105CG0	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity)
Tola_0941	ENOG4105DK0	Indole-3-glycerol phosphate synthase
Tola_0942	ENOG4107QYG	anthranilate phosphoribosyltransferase
Tola_0943	ENOG4108EFP	Anthranilate synthase component II
Tola_0944	ENOG4105CRQ	synthase (Component I)
Tola_0945	ENOG4105DB7	PHP domain protein
Tola_0946	ENOG4107RTD	sua5 ycio yrdc ywlc family protein
Tola_0947	ENOG4105FE9	pseudouridine synthase
Tola_0948	ENOG4105FD2	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity)
Tola_0949	ENOG4108ZGC	gaf domain protein
Tola_0953	ENOG4107K5X	Membrane-bound metal-dependent hydrolase
Tola_0956	ENOG4105C1W	two component, sigma54 specific, transcriptional regulator, Fis family
Tola_0957	ENOG4105KMG	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes (By similarity)
Tola_0958	ENOG4105CEN	a g-specific adenine glycosylase
Tola_0959	ENOG4105CZ1	Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity)
Tola_0960	ENOG4105CSA	Coproporphyrinogen iii oxidase
Tola_0961	ENOG4108V82	Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity)
Tola_0962	ENOG4105VZ9	UPF0235 protein
Tola_0963	ENOG4108VIA	integral membrane protein
Tola_0964	ENOG4105II7	pyrroline-5-carboxylate reductase
Tola_0965	ENOG4105DFA	alanine racemase domain protein
Tola_0966	ENOG4105CZX	twitching motility protein
Tola_0967	ENOG4105CZX	twitching motility protein
Tola_0968	ENOG4105D1Q	UPF0246 protein
Tola_0969	ENOG4105C1J	atp-dependent rna helicase
Tola_0970	ENOG4107S47	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC) (By similarity)
Tola_0971	ENOG41071R3	Low-potential electron donor to a number of redox enzymes (By similarity)
Tola_0972	ENOG4105C13	Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity)
Tola_0974	ENOG4105C2R	Single-stranded-DNA-specific exonuclease (RecJ)
Tola_0976	ENOG4105CRK	lysyL-tRNA synthetase
Tola_0977	ENOG4105C5H	ABC transporter
Tola_0978	ENOG4105CBM	Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 (By similarity)
Tola_0980	ENOG4108SQ9	flavin reductase domain protein, FMN-binding
Tola_0986	ENOG4105CS2	ec 3.2.1.21
Tola_0987	ENOG4105W8I	Transcriptional regulator
Tola_0988	ENOG4105DUK	Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity)
Tola_0990	ENOG4108T9J	Cdp-alcohol phosphatidyltransferase
Tola_0991	ENOG4108VGW	abc transporter atp-binding protein
Tola_0992	ENOG4105CXZ	ABC transporter, permease
Tola_0993	ENOG4105VNH	ABC transporter solute-binding protein
Tola_0995	ENOG4105C1X	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity (By similarity)
Tola_0996	ENOG4105D3Z	quinone oxidoreductase, yhdh yhfp family
Tola_0997	ENOG4108WUH	Transcriptional regulator, TetR family
Tola_0999	ENOG4105E0X	reductase
Tola_1001	ENOG410841Q	phosphoesterase PA-phosphatase related protein
Tola_1005	ENOG4107S21	permease
Tola_1007	ENOG4105D6J	arsenicaL-resistance protein
Tola_1008	ENOG4105WD1	Membrane
Tola_1011	ENOG4105D7K	pfkb domain protein
Tola_1013	ENOG4105EQ7	Binding-protein-dependent transport systems, inner membrane component
Tola_1014	ENOG4105DRS	transport system, permease
Tola_1015	ENOG4108HKT	sucrose-6-phosphate hydrolase
Tola_1017	ENOG4105ETE	Transcriptional regulator (LacI family
Tola_1019	ENOG4105CA9	Pyruvate kinase
Tola_1020	ENOG4106KNT	transcriptional regulator
Tola_1021	ENOG4105CHC	glucokinase (EC 2.7.1.2)
Tola_1023	ENOG4105D0M	Protease HtpX homolog
Tola_1024	ENOG4108V1T	peptidylprolyl cis-trans isomerase
Tola_1025	ENOG4105DUK	Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity)
Tola_1026	ENOG4105C1M	carbamoyl-phosphate synthetase glutamine chain
Tola_1027	ENOG4105CU6	carbamoyl-phosphate synthetase ammonia chain
Tola_1028	ENOG4107AQZ	Membrane
Tola_1030	ENOG41062JF	Transcriptional regulator
Tola_1032	ENOG4105CW7	secretion protein, HlyD family
Tola_1033	ENOG4105C0R	drug resistance transporter emrb qaca subfamily
Tola_1034	ENOG4105C9J	Catalyzes the reversible cleavage of L-rhamnulose-1- phosphate to dihydroxyacetone phosphate (DHAP) and L-lactaldehyde (By similarity)
Tola_1036	ENOG4105CI1	PTS System
Tola_1040	ENOG4105M10	Involved in the anomeric conversion of L-rhamnose (By similarity)
Tola_1041	ENOG4107YRA	Uptake of L-rhamnose across the boundary membrane with the concomitant transport of protons into the cell (symport system) (By similarity)
Tola_1042	ENOG4105DKG	l-rhamnose isomerase
Tola_1043	ENOG4105DET	Rhamnulokinase
Tola_1045	ENOG4105C0A	alcohol dehydrogenase
Tola_1047	ENOG4105C6P	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity)
Tola_1048	ENOG4105ED1	spovr family
Tola_1049	ENOG4106AKX	UPF0229 protein
Tola_1050	ENOG4105CYN	Serine protein kinase
Tola_1053	ENOG4108R6K	riboflavin synthase, subunit alpha
Tola_1054	ENOG4105C1J	atp-dependent rna helicase
Tola_1065	ENOG4105PAD	Hydrolase
Tola_1068	ENOG4105QNF	Outer membrane lipoprotein
Tola_1071	ENOG4105DVT	helicase
Tola_1072	ENOG41072GX	Peptidase M22 Glycoprotease
Tola_1073	ENOG4105Y4Z	Outer Membrane Lipoprotein
Tola_1074	ENOG4105CBF	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity)
Tola_1076	ENOG4105D06	uba thif-type nad fad binding protein
Tola_1079	ENOG4105D41	biosynthesis protein thiH
Tola_1080	ENOG41084GC	stage II sporulation protein
Tola_1081	ENOG4108VKV	Monofunctional biosynthetic peptidoglycan transglycosylase
Tola_1082	ENOG4105DEA	Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation
Tola_1083	ENOG4105CCQ	Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity)
Tola_1084	ENOG4105CHN	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity)
Tola_1085	ENOG4105C6P	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity)
Tola_1086	ENOG4105K70	DNA-binding protein
Tola_1087	ENOG4105EIN	peptidylprolyl cis-trans isomerase
Tola_1088	ENOG41073DY	may be a structural element that influences the osmotic activation of ProP at a post-translational level (By similarity)
Tola_1089	ENOG4105CN1	protease
Tola_1090	ENOG4108HH9	Catalyzes two reactions the first one is the production of beta-formyl glycinamide ribonucleotide (GAR) from formate, ATP and beta GAR
Tola_1091	ENOG4105K85	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity)
Tola_1092	ENOG4105C5S	asparaginyl-tRNA synthetase
Tola_1094	ENOG4105F8D	glycoside hydrolase family 4
Tola_1095	ENOG4105W8I	Transcriptional regulator
Tola_1096	ENOG4108JPX	Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity)
Tola_1097	ENOG4105CZF	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity)
Tola_1098	ENOG4107EEK	Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity)
Tola_1100	ENOG4105E78	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity)
Tola_1101	ENOG4105D0M	Protease HtpX homolog
Tola_1102	ENOG4105C66	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity)
Tola_1103	ENOG4105CFU	surface antigen
Tola_1106	ENOG4108JPW	Aminotransferase
Tola_1107	ENOG4105C26	Dehydrogenase
Tola_1108	ENOG4105EVZ	LysR family transcriptional regulator
Tola_1109	ENOG4105D38	putrescine abc transporter
Tola_1110	ENOG4105F38	ABC transporter, permease
Tola_1112	ENOG4105C53	Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity)
Tola_1113	ENOG4107SEY	Conserved Protein
Tola_1114	ENOG4105CVP	deoxyribo-dipyrimidine photolyase
Tola_1115	ENOG4105CCW	damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity)
Tola_1116	ENOG4105EUJ	GTP cyclohydrolase i
Tola_1117	ENOG4105CJB	Exodeoxyribonuclease I
Tola_1119	ENOG4105KFG	YeeE YedE family protein
Tola_1120	ENOG4105XWI	UPF0304 protein
Tola_1125	ENOG4108YXY	alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
Tola_1126	ENOG4105CDP	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity)
Tola_1130	ENOG4105C9Y	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity)
Tola_1131	ENOG4105KUZ	arsenate reductase
Tola_1132	ENOG4105RKX	Protein of unknown function (DUF2498)
Tola_1133	ENOG4105UYK	outer membrane protein a
Tola_1136	ENOG4107R11	Transcriptional regulator
Tola_1137	ENOG4108I6A	alcohol dehydrogenase
Tola_1142	ENOG4108YGG	dna repair protein
Tola_1156	ENOG4105CVR	type I restriction-modification system
Tola_1157	ENOG4107XZC	Restriction modification system DNA (Specificity
Tola_1166	ENOG4105DKZ	GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity)
Tola_1167	ENOG4105WHM	Necessary for normal cell division and for the maintenance of normal septation (By similarity)
Tola_1170	ENOG4108P8R	
Tola_1173	ENOG41067CV	Integrase
Tola_1174	ENOG4107258	Transcriptional regulator
Tola_1175	ENOG4105CXK	mandelate racemase muconate lactonizing
Tola_1176	ENOG4105CSP	Major Facilitator Superfamily
Tola_1177	ENOG4105CNV	Aldolase
Tola_1178	ENOG4105C0A	alcohol dehydrogenase
Tola_1181	ENOG4105DFS	Conserved Protein
Tola_1185	ENOG4105DZR	Type I site-specific deoxyribonuclease
Tola_1187	ENOG41088T4	Helicase IV
Tola_1190	ENOG4107R3N	Filamentation induced by cAMP protein fic
Tola_1191	ENOG4106TD9	Diguanylate cyclase
Tola_1192	ENOG4105D9K	One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity)
Tola_1193	ENOG4105C8X	One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity)
Tola_1194	ENOG4108R80	One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions. The C subunit may be involved in assembly of the KDP complex (By similarity)
Tola_1195	ENOG4105C08	Histidine kinase
Tola_1196	ENOG4105EEX	Two component transcriptional regulator (Winged helix family
Tola_1199	ENOG4105F4R	Transcriptional regulator mode
Tola_1200	ENOG4108S6J	ABC transporter, periplasmic molybdate-binding protein
Tola_1202	ENOG4108JUA	Transcriptional regulator
Tola_1203	ENOG410635M	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein (By similarity)
Tola_1204	ENOG4105VYW	UPF0251 protein
Tola_1205	ENOG41090R7	Ferric uptake
Tola_1209	ENOG4107QN2	dihydrolipoyl dehydrogenase
Tola_1210	ENOG4105CGB	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system (By similarity)
Tola_1212	ENOG4107XWS	modD protein
Tola_1214	ENOG4105DU1	integral membrane protein, terc
Tola_1217	ENOG4108Z0T	Part of a sulfur-relay system (By similarity)
Tola_1218	ENOG4105EM2	membrane
Tola_1220	ENOG4105CVR	type I restriction-modification system
Tola_1221	ENOG4105EKX	Restriction modification system DNA (Specificity
Tola_1223	ENOG4105DZR	Type I site-specific deoxyribonuclease
Tola_1227	ENOG4108W1A	pseudouridine synthase
Tola_1229	ENOG4105EZ7	amino acid ABC transporter
Tola_1230	ENOG4105DRP	amino acid AbC transporter
Tola_1231	ENOG4105CDA	abc transporter atp-binding protein
Tola_1233	ENOG4105CG3	alpha amylase, catalytic region
Tola_1234	ENOG4108IJ9	(ABC) transporter
Tola_1237	ENOG4107T3P	ABC, transporter
Tola_1238	ENOG4107RSM	transcriptional regulator
Tola_1241	ENOG41061TZ	Short-chain dehydrogenase reductase Sdr
Tola_1245	ENOG4105D60	lipoprotein releasing system transmembrane protein
Tola_1246	ENOG4107R39	(ABC) transporter
Tola_1247	ENOG4107QWK	SAICAR synthetase
Tola_1248	ENOG4107Y66	Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity)
Tola_1249	ENOG4108UJU	UPF0301 protein
Tola_1250	ENOG4105D7Z	glutathione synthase
Tola_1251	ENOG4105QF0	Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity)
Tola_1254	ENOG4105GPY	SprT protein
Tola_1255	ENOG4105CPH	Catalyzes the formation of S-adenosylmethionine from methionine and ATP
Tola_1256	ENOG4105CV1	Transketolase (EC 2.2.1.1)
Tola_1257	ENOG4105BZA	Phosphoglycerate kinase
Tola_1258	ENOG4105D2N	Aldolase
Tola_1259	ENOG4105BZ1	(ABC) transporter
Tola_1268	ENOG4107T1C	Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate (By similarity)
Tola_1271	ENOG4105CJ3	phosphate transporter
Tola_1273	ENOG4105PTV	Nudix Hydrolase
Tola_1274	ENOG4105E0M	Sulfatase
Tola_1275	ENOG4105BZU	Histidine kinase
Tola_1276	ENOG4105CQ7	ATP-dependent helicase
Tola_1278	ENOG4105VEQ	Cold shock protein
Tola_1279	ENOG4105BZ1	(ABC) transporter
Tola_1280	ENOG4105BZ1	(ABC) transporter
Tola_1281	ENOG4105HPZ	Involved in the removal of murein from the sacculus. May also facilitate integration of nascent murein strands into the sacculus by cleaving the peptide bonds between neighboring strands in mature murein (By similarity)
Tola_1283	ENOG4105M2E	Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity)
Tola_1288	ENOG4105C37	(CBS) domain
Tola_1292	ENOG4108YZN	class I peptide chain release factor
Tola_1296	ENOG410829K	Lysine exporter protein (Lyse ygga)
Tola_1300	ENOG4105D3G	Pseudouridine synthase
Tola_1303	ENOG4105DXC	membrane
Tola_1307	ENOG4105KHC	sulfurtransferase
Tola_1313	ENOG4105QNR	S1 RNA binding domain protein
Tola_1314	ENOG4105BZU	Histidine kinase
Tola_1315	ENOG4108VWS	Yaeq family
Tola_1316	ENOG4105EE0	oxidoreductase
Tola_1318	ENOG4108HRN	Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity)
Tola_1320	ENOG4105CJJ	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity)
Tola_1321	ENOG4105BZU	Histidine kinase
Tola_1322	ENOG4105CGY	Dna recombination protein
Tola_1325	ENOG4105EQ2	LysR family Transcriptional regulator
Tola_1327	ENOG4105EBR	Carboxylesterase
Tola_1328	ENOG4105EBR	Carboxylesterase
Tola_1329	ENOG4105CPC	Aldo Keto reductase
Tola_1330	ENOG4105ENX	hydrolase
Tola_1334	ENOG41066F8	ROK family
Tola_1337	ENOG4105DRS	transport system, permease
Tola_1339	ENOG4107QW3	Sucrose phosphorylase
Tola_1342	ENOG4105CUB	amino acid
Tola_1345	ENOG41090KN	UPF0303 protein
Tola_1347	ENOG4105BZU	Histidine kinase
Tola_1348	ENOG4105IPI	Membrane
Tola_1351	ENOG4105DHJ	ABC, transporter
Tola_1353	ENOG4105CQU	Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity)
Tola_1355	ENOG4107X8C	Efflux transporter RND family MFP subunit
Tola_1358	ENOG4107SV5	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. May be involved in the integration of spacer DNA into the CRISPR cassette (By similarity)
Tola_1359	ENOG4107IIZ	CRISPR-associated helicase, Cas3
Tola_1360	ENOG4105ENG	CRISPR-associated protein, Csy1 family
Tola_1361	ENOG4105DZX	CRISPR-associated protein, Csy2 family
Tola_1362	ENOG4105M6W	Crispr-associated protein, Csy3 family
Tola_1363	ENOG4108Y1S	CRISPR-associated protein, Csy4 family
Tola_1364	ENOG4107QM1	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity)
Tola_1365	ENOG4105CMY	5-enolpyruvylshikimate-3-phosphate synthase
Tola_1366	ENOG4108JQ1	Dehydrogenase
Tola_1368	ENOG4105C6H	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity)
Tola_1370	ENOG4108NEV	two component transcriptional regulator, LytTR family
Tola_1371	ENOG4108HRK	Histidine kinase
Tola_1372	ENOG4105DIH	basic membrane
Tola_1373	ENOG4108JQ9	ABC transporter
Tola_1374	ENOG4105UIB	(ABC) transporter
Tola_1376	ENOG4105E99	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity)
Tola_1379	ENOG4105C87	Aminotransferase class I and II
Tola_1381	ENOG4105C5Q	Transcriptional regulator
Tola_1382	ENOG4105ERU	peptidase
Tola_1383	ENOG4105C73	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity)
Tola_1385	ENOG4105CRQ	synthase (Component I)
Tola_1386	ENOG4105C1W	two component, sigma54 specific, transcriptional regulator, Fis family
Tola_1388	ENOG4105BZU	Histidine kinase
Tola_1389	ENOG4105C1J	atp-dependent rna helicase
Tola_1390	ENOG4105E99	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity)
Tola_1391	ENOG4107UW8	HAD-superfamily hydrolase subfamily IA variant 3
Tola_1392	ENOG4107QI1	Mate efflux family protein
Tola_1393	ENOG4105W1I	UPF0253 protein
Tola_1394	ENOG4105FGM	Fructosamine kinase
Tola_1395	ENOG4105CZX	twitching motility protein
Tola_1397	ENOG4105I08	Pseudouridine synthase
Tola_1398	ENOG4108ZK7	protein family UPF0029, Impact, N-terminal protein
Tola_1400	ENOG4105JQN	Transcriptional regulator
Tola_1407	ENOG4105C6Y	Udp-glucose 6-dehydrogenase
Tola_1408	ENOG4105KZJ	alginate biosynthesis protein Alg8
Tola_1409	ENOG4108UIA	Alginate biosynthesis protein Alg44
Tola_1411	ENOG4108C0K	Bifunctional protein that converts poly(beta-D- mannuronate) to alpha-L-guluronate and that is also part of a periplasmic protein complex that serves as a scaffold that leads the newly formed alginate polymer through the periplasmic space to the outer membrane secretin AlgE
Tola_1414	ENOG4105CJT	Mannose-1-phosphate guanylyltransferase
Tola_1416	ENOG4105EIP	mannose-6-phosphate isomerase
Tola_1418	ENOG4105C4H	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity)
Tola_1419	ENOG4105C5H	ABC transporter
Tola_1421	ENOG4105WFT	During stationary phase, converts 70S ribosomes to an inactive dimeric form (100S ribosomes) (By similarity)
Tola_1422	ENOG4108RKI	Necessary for the introduction of cis unsaturation into fatty acids. Catalyzes the dehydration of (3R)-3-hydroxydecanoyl- ACP to E-(2)-decenoyl-ACP and then its isomerization to Z-(3)- decenoyl-ACP. Can catalyze the dehydratase reaction for beta- hydroxyacyl-ACPs with saturated chain lengths up to 16 0, being most active on intermediate chain length (By similarity)
Tola_1423	ENOG4105DAN	ATP-dependent protease
Tola_1425	ENOG4106IUH	DTW domain containing protein
Tola_1428	ENOG4105E05	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity)
Tola_1429	ENOG4105BZH	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity)
Tola_1430	ENOG4108VXP	Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity)
Tola_1432	ENOG4105C24	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
Tola_1434	ENOG4105CY8	phosphoribosylaminoimidazole carboxylase atpase subunit
Tola_1435	ENOG4108UM6	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity)
Tola_1438	ENOG41063Z6	transcriptional regulator, lysR family
Tola_1439	ENOG4105FBT	Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs (By similarity)
Tola_1440	ENOG4105DH5	Responsible for the end-turnover of tRNA specifically removes the terminal AMP residue from uncharged tRNA (tRNA-C-C-A). Also appears to be involved in tRNA biosynthesis (By similarity)
Tola_1442	ENOG4108UYE	Lactoylglutathione lyase
Tola_1443	ENOG4105CSM	endonuclease III
Tola_1445	ENOG4108UQQ	Electron transport complex
Tola_1446	ENOG4105D6A	Electron transport complex
Tola_1447	ENOG4107QTR	Required for nitrogen fixation. May be part of a membrane complex functioning as an intermediate in the electron transport to nitrogenase (By similarity)
Tola_1448	ENOG4108R3D	Electron transport complex
Tola_1449	ENOG4105DGN	Electron transport complex
Tola_1452	ENOG4108VKG	metal-dependent hydrolase
Tola_1453	ENOG4105VYA	Uncharacterized conserved protein (DUF2132)
Tola_1454	ENOG4105EJ9	Membrane
Tola_1456	ENOG4105CPB	ATP-dependent endonuclease of the OLD family
Tola_1457	ENOG4105CTQ	phosphohexokinase
Tola_1459	ENOG4107S90	membrAne
Tola_1460	ENOG4106371	Methyltransferase
Tola_1461	ENOG4105GHU	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity (By similarity)
Tola_1462	ENOG4105DAH	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF (By similarity)
Tola_1463	ENOG4105DUC	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division (By similarity)
Tola_1465	ENOG410600T	transposase
Tola_1467	ENOG4105CGF	Aromatic amino acid aminotransferase
Tola_1470	ENOG4105UIB	(ABC) transporter
Tola_1471	ENOG4108JQ9	ABC transporter
Tola_1472	ENOG41088T4	Helicase IV
Tola_1473	ENOG4105EU0	Major facilitator Superfamily
Tola_1474	ENOG4108TEB	UPF0114 protein
Tola_1476	ENOG4105FQ6	thiopurine methyltransferase
Tola_1479	ENOG4108Z4T	Peptidase M50
Tola_1482	ENOG4105CS2	ec 3.2.1.21
Tola_1483	ENOG4105W3H	MtN3 and saliva related transmembrane protein
Tola_1484	ENOG4105CDH	Citrulline--aspartate ligase
Tola_1485	ENOG4105E0A	ABC, transporter
Tola_1486	ENOG4105J76	Periplasmic binding protein
Tola_1487	ENOG4105S6R	Iron-hydroxamate transporter permease subunit
Tola_1489	ENOG4105IBP	Cyclic peptide transporter
Tola_1491	ENOG4106P55	Transcriptional regulator
Tola_1492	ENOG4108I6A	alcohol dehydrogenase
Tola_1494	ENOG4105CHH	sulfate transporter
Tola_1495	ENOG4105CCY	NADH flavin oxidoreductase, NADH oxidase
Tola_1497	ENOG4107R5I	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine (By similarity)
Tola_1498	ENOG4105EQ2	LysR family Transcriptional regulator
Tola_1500	ENOG4105EBR	Carboxylesterase
Tola_1501	ENOG4105EQ2	LysR family Transcriptional regulator
Tola_1502	ENOG4107SET	aldo keto reductase
Tola_1506	ENOG4107QHI	-hydrogenase
Tola_1513	ENOG4105DWT	malate dehydrogenase (quinone)
Tola_1516	ENOG4105CVE	Lytic murein transglycosylase
Tola_1519	ENOG4105CPC	Aldo Keto reductase
Tola_1522	ENOG4105DHT	Metal Dependent Phosphohydrolase
Tola_1524	ENOG4105CGF	Aromatic amino acid aminotransferase
Tola_1525	ENOG4107U5X	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity)
Tola_1527	ENOG4105N2W	Transcriptional regulator
Tola_1528	ENOG4105DHP	deoxycytidine triphosphate deaminase
Tola_1529	ENOG4105DBI	uridine monophosphokinase
Tola_1530	ENOG4105D1F	ATP-binding protein
Tola_1531	ENOG4105CKH	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity)
Tola_1533	ENOG4105EZE	Cupin 4 family protein
Tola_1535	ENOG4105CUB	amino acid
Tola_1536	ENOG4105CPD	ethanolamine ammonia-lyase
Tola_1538	ENOG4105C5I	Dehydrogenase
Tola_1539	ENOG4106HK8	GPR1 FUN34 yaaH family protein
Tola_1540	ENOG4105CEP	NADH dehydrogenase
Tola_1542	ENOG4107QPA	Cleaves GlcNAc linked beta-1,4 to MurNAc tripeptides (By similarity)
Tola_1543	ENOG4105CQC	Prephenate dehydratase
Tola_1545	ENOG4107QYT	Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor (By similarity)
Tola_1546	ENOG4105CD8	aminopeptidase N
Tola_1547	ENOG4105WH1	Two component transcriptional regulator luxr family
Tola_1548	ENOG4105CII	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity)
Tola_1553	ENOG4106EG9	Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) (By similarity)
Tola_1554	ENOG4105CFV	Tetratricopeptide repeat protein
Tola_1556	ENOG41080YA	This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity)
Tola_1557	ENOG4105CAV	thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity)
Tola_1558	ENOG4105CAT	Cytidine monophosphate kinase
Tola_1559	ENOG4108ZZ3	UPF0260 protein
Tola_1560	ENOG4105VNG	YcgL domain-containing protein
Tola_1561	ENOG4105K7U	Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization (By similarity)
Tola_1562	ENOG4107QMS	site-determining protein
Tola_1563	ENOG4105VJP	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell (By similarity)
Tola_1564	ENOG4105ZIE	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides (By similarity)
Tola_1565	ENOG4107QNR	UPF0135 protein
Tola_1566	ENOG4108S3P	Sporulation domain protein
Tola_1567	ENOG4105DPM	folylpolyglutamate synthase Dihydrofolate synthase
Tola_1568	ENOG4107QTG	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA (By similarity)
Tola_1569	ENOG4105DI7	Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity)
Tola_1571	ENOG4105CM3	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity)
Tola_1572	ENOG4105CJ0	Catalyzes the oxidation of erythronate-4-phosphate to 3- hydroxy-2-oxo-4-phosphonooxybutanoate (By similarity)
Tola_1574	ENOG4105CWG	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34 (By similarity)
Tola_1575	ENOG4107QUT	magnesium and cobalt transport protein CorA
Tola_1577	ENOG4105C9Q	fumarate hydratase class II
Tola_1578	ENOG4108JEH	abc transporter atp-binding protein
Tola_1579	ENOG4106YG3	ABC transporter
Tola_1580	ENOG4105DSP	amino acid AbC transporter
Tola_1581	ENOG4105E89	ABC transporter
Tola_1582	ENOG4105EJF	Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity)
Tola_1583	ENOG4105VCN	Rescues the ribosomes stalled at the 3' end of non-stop mRNAs. May induce hydrolysis of the ribosome-bound peptidyl-tRNA. This activity is crucial when the stalled ribosome can not be rescued by the SsrA(tmRNA)-SmpB quality control system
Tola_1589	ENOG4105CCW	damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity)
Tola_1592	ENOG4105C3X	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity)
Tola_1606	ENOG4105D70	Integrase catalytic subunit
Tola_1607	ENOG4105F5W	AtP-binding protein
Tola_1609	ENOG4105C4R	Atp-dependent dna helicase
Tola_1610	ENOG4105CDB	Required for chromosome condensation and partitioning (By similarity)
Tola_1615	ENOG4105E8T	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG (By similarity)
Tola_1616	ENOG4108YH3	Required for maturation of urease via the functional incorporation of the urease nickel metallocenter (By similarity)
Tola_1618	ENOG4105MMR	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly (By similarity)
Tola_1619	ENOG4105CQM	Urea amidohydrolase subunit alpha
Tola_1620	ENOG4105KI2	Urea amidohydrolase subunit beta
Tola_1621	ENOG4108YZ9	Urea amidohydrolase subunit gamma
Tola_1622	ENOG4108M9X	Required for maturation of urease via the functional incorporation of the urease nickel metallocenter (By similarity)
Tola_1623	ENOG4108IV0	ABC, transporter
Tola_1624	ENOG4105C0Z	ABC transporter
Tola_1626	ENOG4105C32	Amino acid ABC transporter (Permease)
Tola_1628	ENOG4105BZU	Histidine kinase
Tola_1629	ENOG4105DPZ	Two component transcriptional regulator (Winged helix family
Tola_1631	ENOG4108JEH	abc transporter atp-binding protein
Tola_1632	ENOG4106TNF	Periplasmic binding protein
Tola_1633	ENOG4105DSP	amino acid AbC transporter
Tola_1635	ENOG4105C28	cystathionine
Tola_1636	ENOG4108594	Permease of the drug metabolite transporter
Tola_1637	ENOG4105Q9Y	Universal stress protein
Tola_1642	ENOG4105CHF	Glutathione S-transferase
Tola_1649	ENOG4105EBR	Carboxylesterase
Tola_1654	ENOG4105F7P	transcriptional regulator AsnC family
Tola_1655	ENOG410829K	Lysine exporter protein (Lyse ygga)
Tola_1657	ENOG4105D18	nicotinate-nucleotide pyrophosphorylase
Tola_1661	ENOG4105VYW	UPF0251 protein
Tola_1662	ENOG4105CUP	Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB) (By similarity)
Tola_1663	ENOG4108UHF	Joins Ado-cobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin) (By similarity)
Tola_1664	ENOG4108YZT	Adenosylcobinamide kinase
Tola_1665	ENOG4105CAA	catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity)
Tola_1667	ENOG4108V4M	Cobalt abc transporter
Tola_1668	ENOG4105W4R	Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import (By similarity)
Tola_1669	ENOG4105CFT	Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import (By similarity)
Tola_1670	ENOG4105DVK	Precorrin-2 c20-methyltransferase
Tola_1671	ENOG4107PPM	cobalt chelatase
Tola_1672	ENOG4105QUC	reductase
Tola_1673	ENOG4105E4R	Precorrin-3B C17-methyltransferase
Tola_1674	ENOG4108P62	biosynthesis protein (CbiG)
Tola_1675	ENOG4105CIA	precorrin-4 C(11)-methyltransferase
Tola_1676	ENOG4107XSI	cobalt-precorrin-6y C15-methyltransferase
Tola_1677	ENOG4108DR9	Cobalt-precorrin-6Y C(5)-methyltransferase
Tola_1678	ENOG4105EE8	May catalyze the methylation of C-1 in cobalt-precorrin- 5 and the subsequent extrusion of acetic acid from the resulting intermediate to form cobalt-precorrin-6A (By similarity)
Tola_1679	ENOG41081F0	Precorrin-8x methylmutase
Tola_1680	ENOG4105DH2	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group (By similarity)
Tola_1681	ENOG4105C0Y	Responsible for the amidation of carboxylic groups at position A and C of either cobyrinic acid or hydrogenobrynic acid. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity)
Tola_1682	ENOG4107XVH	Transcriptional regulator
Tola_1683	ENOG4105D8C	Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity)
Tola_1684	ENOG4105KNY	Microcompartments protein
Tola_1685	ENOG4105EHR	propanediol utilization protein pduB
Tola_1686	ENOG4105DMB	glycerol dehydratase
Tola_1687	ENOG4105YCI	dehydratase medium subunit
Tola_1688	ENOG4108ZFT	Dehydratase small subunit
Tola_1689	ENOG41084PW	diol glycerol dehydratase reactivating factor large subunit
Tola_1691	ENOG4105KNY	Microcompartments protein
Tola_1692	ENOG4105S3V	Carbon dioxide concentrating mechanism protein
Tola_1693	ENOG4108VPX	Involved in 1,2-propanediol (1,2-PD) degradation by catalyzing the conversion of propanoyl-CoA to propanoyl-phosphate (By similarity)
Tola_1697	ENOG4108EKI	Dehydrogenase
Tola_1699	ENOG4107QTR	Required for nitrogen fixation. May be part of a membrane complex functioning as an intermediate in the electron transport to nitrogenase (By similarity)
Tola_1701	ENOG4105M3W	utilization protein
Tola_1702	ENOG4105KTW	ethanolamine utilization protein
Tola_1703	ENOG4105C6H	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity)
Tola_1704	ENOG4105CB8	Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity)
Tola_1705	ENOG4107QZB	decarboxylase
Tola_1706	ENOG4105JZC	GHMP kinase
Tola_1707	ENOG4105CUK	Alpha-N-arabinofuranosidase (EC 3.2.1.55)
Tola_1708	ENOG4105ETE	Transcriptional regulator (LacI family
Tola_1710	ENOG4105F66	Binding-protein-dependent transport systems inner membrane component
Tola_1711	ENOG4105EQ7	Binding-protein-dependent transport systems, inner membrane component
Tola_1712	ENOG4105C53	Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity)
Tola_1714	ENOG4107QK4	glycoside hydrolase, family 3 domain protein
Tola_1717	ENOG410635M	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein (By similarity)
Tola_1718	ENOG4105C7R	Atpase associated with various cellular activities aaa_3
Tola_1724	ENOG4108ZUF	This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity)
Tola_1725	ENOG4105C6A	phenylalanyl-tRNA synthetase (beta subunit)
Tola_1726	ENOG4105CSS	phenylalanyl-tRNA synthetase (alpha subunit)
Tola_1727	ENOG4108YZX	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity)
Tola_1728	ENOG41082NX	50s ribosomal protein l35
Tola_1730	ENOG4105C22	threonyL-tRNA synthetase
Tola_1731	ENOG4105KW6	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity)
Tola_1732	ENOG41080IJ	Diacylglycerol kinase
Tola_1733	ENOG41080WI	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system (By similarity)
Tola_1735	ENOG4105E21	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity)
Tola_1736	ENOG4105CEK	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity)
Tola_1737	ENOG4105CIH	Imidazole acetol-phosphate transaminase
Tola_1739	ENOG4108UJE	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity)
Tola_1740	ENOG4105CJV	Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase
Tola_1741	ENOG4105C0S	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity)
Tola_1742	ENOG4105K8F	Phosphoribosyl-amp cyclohydrolase
Tola_1743	ENOG4105BZU	Histidine kinase
Tola_1744	ENOG4108T3F	Repressor of the marRAB operon which is involved in the activation of both antibiotic resistance and oxidative stress genes
Tola_1746	ENOG4105CW7	secretion protein, HlyD family
Tola_1747	ENOG4105C0R	drug resistance transporter emrb qaca subfamily
Tola_1750	ENOG4105C80	Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity)
Tola_1755	ENOG4108ZAF	Molybdopterin
Tola_1756	ENOG4105M00	molybdopterin converting factor, subunit 1
Tola_1757	ENOG4108YXW	Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity)
Tola_1758	ENOG4108RIR	Molybdenum cofactor biosynthesis protein
Tola_1759	ENOG41085AN	Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity)
Tola_1760	ENOG4105CM1	Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity)
Tola_1761	ENOG4105D06	uba thif-type nad fad binding protein
Tola_1762	ENOG4105CVM	Molybdenum cofactor synthesis domain protein
Tola_1764	ENOG4107QZF	nitrite reductase NADPH large subunit
Tola_1766	ENOG4107R3J	Transporter
Tola_1767	ENOG4105EJC	lysr family transcriptional regulator
Tola_1769	ENOG4105CCY	NADH flavin oxidoreductase, NADH oxidase
Tola_1770	ENOG4105D7T	ABC transporter
Tola_1774	ENOG4105CB8	Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity)
Tola_1776	ENOG4108RG0	uracil-dna glycosylase
Tola_1780	ENOG4105C5I	Dehydrogenase
Tola_1782	ENOG4107RGD	Major Facilitator superfamily
Tola_1784	ENOG4105MVE	transcriptional regulator
Tola_1786	ENOG4105CPC	Aldo Keto reductase
Tola_1789	ENOG4105EJC	lysr family transcriptional regulator
Tola_1790	ENOG4107QW4	alcohol dehydrogenase
Tola_1792	ENOG4105D7K	pfkb domain protein
Tola_1794	ENOG4105C5I	Dehydrogenase
Tola_1795	ENOG4105C01	Dihydroxy-acid dehydratase
Tola_1796	ENOG4108UHU	Aldolase
Tola_1799	ENOG4108M60	Transcriptional regulator
Tola_1802	ENOG4105WQ5	TonB family
Tola_1803	ENOG41061EV	selenium-binding protein YdfZ
Tola_1805	ENOG4108KK1	membrane protein AbrB duplication
Tola_1806	ENOG4105R8A	Heat shock protein
Tola_1808	ENOG410904N	short-chain dehydrogenase reductase
Tola_1815	ENOG4108DBC	nitroreductase
Tola_1818	ENOG4105W2W	Cytotoxic translational repressor of toxin-antitoxin stability system
Tola_1819	ENOG4105W08	virulence gene repressor rsal
Tola_1820	ENOG4105W39	Membrane
Tola_1823	ENOG4105DP0	ferredoxin-NADP reductase
Tola_1824	ENOG4108EQM	faD-dependent pyridine nucleotide-disulfide oxidoreductase
Tola_1826	ENOG410626R	Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity)
Tola_1827	ENOG4105DKT	Transcriptional regulator
Tola_1829	ENOG4105MRB	Catalyzes the interconversion of beta-pyran and beta- furan forms of D-ribose (By similarity)
Tola_1831	ENOG4107QVN	Key enzyme in the regulation of glycerol uptake and metabolism (By similarity)
Tola_1832	ENOG4108IUS	Transketolase
Tola_1833	ENOG4108HHA	Transketolase
Tola_1834	ENOG4105CNN	ABC, transporter
Tola_1835	ENOG4105C2J	ABC transporter
Tola_1838	ENOG4105CW3	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity)
Tola_1839	ENOG4105CV1	Transketolase (EC 2.2.1.1)
Tola_1840	ENOG4108JUA	Transcriptional regulator
Tola_1841	ENOG4105FJH	Di-iron-containing protein involved in the repair of iron-sulfur clusters damaged by oxidative and nitrosative stress conditions (By similarity)
Tola_1842	ENOG4105CJJ	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity)
Tola_1843	ENOG4105BZU	Histidine kinase
Tola_1844	ENOG4105C52	Atpase, p-type (Transporting), had superfamily, subfamily ic
Tola_1846	ENOG4105DUM	transcriptional regulator, lysR family
Tola_1847	ENOG4105CER	acetyl-CoA carboxylase biotin carboxylase
Tola_1848	ENOG4107QSA	Oxaloacetate decarboxylase
Tola_1849	ENOG4105DIJ	Phosphoethanolamine transferase
Tola_1853	ENOG4105C87	Aminotransferase class I and II
Tola_1855	ENOG4107RTG	Major Facilitator superfamily
Tola_1857	ENOG4105C5A	transporter
Tola_1858	ENOG4105E7W	lamb ycsf family protein
Tola_1859	ENOG4107R7A	Allophanate hydrolase subunit 2
Tola_1860	ENOG4105P4J	Allophanate hydrolase, subunit 1
Tola_1863	ENOG4105CDA	abc transporter atp-binding protein
Tola_1868	ENOG4105E7U	AraC family transcriptional regulator
Tola_1873	ENOG410804X	Transcriptional regulator
Tola_1875	ENOG4107QMF	Sorbitol-6-phosphate dehydrogenase
Tola_1876	ENOG4105VI0	Pts system, glucitol sorbitol-specific
Tola_1877	ENOG4105DZY	Pts system, glucitol sorbitol-specific
Tola_1878	ENOG410787A	Pts system, glucitol sorbitol-specific
Tola_1885	ENOG4107XVH	Transcriptional regulator
Tola_1887	ENOG4105C2X	Arabinose 5-phosphate isomerase
Tola_1888	ENOG4105EE0	oxidoreductase
Tola_1889	ENOG4105CF9	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation (By similarity)
Tola_1890	ENOG4105CZI	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
Tola_1891	ENOG4108HRN	Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity)
Tola_1892	ENOG4105DCT	glycerol dehydrogenase
Tola_1893	ENOG4107T9Z	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity)
Tola_1894	ENOG4105D8C	Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity)
Tola_1895	ENOG4106R3P	AraC family transcriptional regulator
Tola_1896	ENOG4105C6H	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity)
Tola_1897	ENOG4106R3P	AraC family transcriptional regulator
Tola_1898	ENOG4108XCZ	PTS System
Tola_1899	ENOG4105DM4	PTS System
Tola_1901	ENOG4108AHH	pyruvate formate lyase II activase
Tola_1902	ENOG4105C6N	Formate acetyltransferase
Tola_1903	ENOG4108YRF	PTS System
Tola_1904	ENOG4105DM4	PTS System
Tola_1905	ENOG4105DM4	PTS System
Tola_1907	ENOG4105BZ3	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity)
Tola_1915	ENOG4105CN0	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity)
Tola_1918	ENOG4105C8N	cysteinyl-tRNA synthetase
Tola_1919	ENOG4108R5K	PPIases accelerate the folding of proteins (By similarity)
Tola_1920	ENOG4105F10	Catalyzes the hydrolysis of the pyrophosphate bond of UDP-2,3-diacylglucosamine to yield 2,3-diacylglucosamine 1- phosphate (lipid X) and UMP (By similarity)
Tola_1924	ENOG4105D9P	serine threonine protein kinase
Tola_1928	ENOG4107QW4	alcohol dehydrogenase
Tola_1930	ENOG4105ENX	hydrolase
Tola_1932	ENOG4105CF7	AraC family transcriptional regulator
Tola_1934	ENOG4107A4G	HTH_XRE
Tola_1936	ENOG4108KSB	HipA-like N-terminal domain
Tola_1940	ENOG4106KNT	transcriptional regulator
Tola_1941	ENOG4105CNN	ABC, transporter
Tola_1942	ENOG4105C2J	ABC transporter
Tola_1946	ENOG4105CT4	transporter
Tola_1949	ENOG4105CBZ	Short-chain dehydrogenase reductase Sdr
Tola_1951	ENOG4105CEY	Amp-dependent synthetase and ligase
Tola_1953	ENOG4105BZU	Histidine kinase
Tola_1955	ENOG4105C5R	Aminotransferase
Tola_1957	ENOG4105CFB	Gamma-glutamyltranspeptidase (EC 2.3.2.2)
Tola_1960	ENOG4105C6F	GntR Family Transcriptional Regulator
Tola_1961	ENOG4105C53	Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity)
Tola_1963	ENOG4105F38	ABC transporter, permease
Tola_1964	ENOG4105C8U	phosphate abc transporter
Tola_1967	ENOG4105WKS	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity)
Tola_1968	ENOG4105X8U	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation (By similarity)
Tola_1969	ENOG4105DCX	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity)
Tola_1970	ENOG4107TFG	D-allose kinase
Tola_1971	ENOG4105UP7	3-epimerase
Tola_1972	ENOG4105CNN	ABC, transporter
Tola_1973	ENOG4105C2J	ABC transporter
Tola_1974	ENOG4105E9V	Periplasmic binding protein LacI transcriptional regulator
Tola_1975	ENOG4105NYY	transcriptional regulator, RpiR
Tola_1978	ENOG4105DJV	ribulose-phosphate 3-epimerase
Tola_1979	ENOG4108YZG	isomerase
Tola_1982	ENOG4105DRP	amino acid AbC transporter
Tola_1983	ENOG4105E5Q	amino acid AbC transporter
Tola_1990	ENOG4105EQ2	LysR family Transcriptional regulator
Tola_1991	ENOG4105CPC	Aldo Keto reductase
Tola_1993	ENOG4105EQ0	Major Facilitator superfamily
Tola_1994	ENOG4105EQ2	LysR family Transcriptional regulator
Tola_1995	ENOG4105BZ8	glutamate synthase
Tola_1998	ENOG4105BZU	Histidine kinase
Tola_2001	ENOG4105CPC	Aldo Keto reductase
Tola_2003	ENOG4105C0Q	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity)
Tola_2004	ENOG4105DR4	Methyltransferase
Tola_2005	ENOG4105CUP	Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB) (By similarity)
Tola_2007	ENOG41068B1	Cob-I-yrinic acid a,c-diamide adenosyltransferase
Tola_2008	ENOG4105C5X	domain protein
Tola_2009	ENOG4105F04	LysR family Transcriptional regulator
Tola_2011	ENOG410903C	(LipO)protein
Tola_2012	ENOG4108UGX	Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity)
Tola_2013	ENOG4105BZ6	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity)
Tola_2014	ENOG4108ZIT	Ferredoxin, 2FE-2S
Tola_2015	ENOG4105C9I	Chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Has a low intrinsic ATPase activity which is markedly stimulated by HscB
Tola_2017	ENOG4108Z4V	iron-sulfur cluster assembly
Tola_2018	ENOG4107XTC	May be involved in the formation or repair of Fe-S clusters present in iron-sulfur proteins
Tola_2019	ENOG4105C3J	Cysteine desulfurase
Tola_2020	ENOG4108ZF1	Transcriptional regulator, BadM Rrf2 family
Tola_2022	ENOG4105XPQ	lipid carrier protein
Tola_2023	ENOG4105CFP	Peptidase U32
Tola_2024	ENOG4106RZ4	Peptidase U32
Tola_2026	ENOG4105KHC	sulfurtransferase
Tola_2027	ENOG4107RAB	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity)
Tola_2028	ENOG4107QN8	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity)
Tola_2029	ENOG4105VIE	preprotein translocase, subunit YajC
Tola_2030	ENOG4105C6U	Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity)
Tola_2031	ENOG4105E2N	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity)
Tola_2033	ENOG4105E66	phosphoriboisomerase A
Tola_2034	ENOG4105ESV	Glycosyl transferase, family 4
Tola_2039	ENOG4105C1B	dTDP-glucose 4-6-dehydratase
Tola_2040	ENOG4108URP	Dtdp-4-dehydrorhamnose 3,5-epimerase
Tola_2044	ENOG4105D3Q	Sugar transferase
Tola_2045	ENOG4108KBE	Glycosyl transferase, family 2
Tola_2046	ENOG4105CTC	Lipopolysaccharide biosynthesis protein-like protein
Tola_2049	ENOG4107QKV	phosphomannomutase
Tola_2050	ENOG4105CJT	Mannose-1-phosphate guanylyltransferase
Tola_2051	ENOG4105FGF	GDP-mannose mannosyl hydrolase
Tola_2052	ENOG4105C30	Nad-dependent epimerase dehydratase
Tola_2053	ENOG4105C0K	Gdp-mannose 4,6-dehydratase
Tola_2056	ENOG4105CMR	udp-glucose 4-epimerase
Tola_2059	ENOG4108UTW	Plays a role in the regulation of phosphate uptake
Tola_2060	ENOG4105BZY	Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity)
Tola_2061	ENOG4105E2Z	phosphate ABC transporter (Permease
Tola_2062	ENOG4105C8U	phosphate abc transporter
Tola_2063	ENOG4105CUU	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity)
Tola_2064	ENOG4105C9X	ppx gppa phosphatase
Tola_2065	ENOG4108Z6B	deaminase
Tola_2067	ENOG4105BZU	Histidine kinase
Tola_2068	ENOG4105CK6	Two component transcriptional regulator (Winged helix family
Tola_2069	ENOG4105EYH	Exonuclease
Tola_2070	ENOG4107RH8	nuclease SbcCD subunit D
Tola_2072	ENOG4105DH7	May be involved in recombination (By similarity)
Tola_2073	ENOG4105CFP	Peptidase U32
Tola_2074	ENOG4105K5D	4fe-4S ferredoxin iroN-sulfur binding
Tola_2075	ENOG41090BQ	Glutaredoxin
Tola_2077	ENOG4105DKK	Benzoate
Tola_2078	ENOG4108JCI	Transcriptional regulator
Tola_2079	ENOG4105BZU	Histidine kinase
Tola_2080	ENOG4105F9E	Shikimate 5-dehydrogenase
Tola_2081	ENOG4107RDB	Major Facilitator
Tola_2082	ENOG4105F1R	Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity)
Tola_2083	ENOG41090KH	cytochrome o ubiquinol oxidase (subunit iv)
Tola_2084	ENOG4105CCU	oxidase (Subunit III)
Tola_2085	ENOG4105BZ9	Cytochrome C oxidase, subunit I
Tola_2086	ENOG4105E2S	oxidase) subunit II
Tola_2087	ENOG4105DW3	Response regulator receiver modulated metal dependent phosphohydrolase
Tola_2091	ENOG4105DM4	PTS System
Tola_2093	ENOG41074MP	UPF0103 Mediator of ErbB2-driven cell motility-containing protein
Tola_2094	ENOG4105NBF	ammecr1 domain protein
Tola_2095	ENOG4107QM9	Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (By similarity)
Tola_2096	ENOG4105C0B	DNA polymerase III (alpha subunit)
Tola_2097	ENOG4108UH2	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity)
Tola_2098	ENOG4105D0V	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity)
Tola_2099	ENOG4105DAF	Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity)
Tola_2100	ENOG4108YXN	Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity)
Tola_2101	ENOG4105D7M	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity)
Tola_2102	ENOG4108RFI	Molecular chaperone that interacts specifically with outer membrane proteins, thus maintaining the solubility of early folding intermediates during passage through the periplasm (By similarity)
Tola_2103	ENOG4105E1Z	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
Tola_2104	ENOG4105DZP	Membrane-associated zinc metalloprotease
Tola_2105	ENOG4105CEA	Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity)
Tola_2106	ENOG4105KNE	Phosphatidate cytidylyltransferase
Tola_2107	ENOG4105CR3	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity)
Tola_2108	ENOG4108VCV	Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity)
Tola_2109	ENOG4105C41	Catalyzes the reversible phosphorylation of UMP to UDP (By similarity)
Tola_2110	ENOG4105CU7	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity)
Tola_2111	ENOG4105CE9	30S ribosomal protein S2
Tola_2113	ENOG4105CA1	Removes the N-terminal methionine from nascent proteins (By similarity)
Tola_2114	ENOG4105E1P	Modifies, by uridylylation or deuridylylation the PII (GlnB) regulatory protein (By similarity)
Tola_2115	ENOG4105DMJ	Catalyzes the transfer of an acetyl group from acetyl- CoA to tetrahydrodipicolinate (By similarity)
Tola_2120	ENOG4105C2T	Binding-protein-dependent transport systems, inner membrane component
Tola_2121	ENOG4108JQ5	ABC transporter
Tola_2122	ENOG4105CPC	Aldo Keto reductase
Tola_2123	ENOG4108K2B	transcriptional regulator
Tola_2124	ENOG4105F8D	glycoside hydrolase family 4
Tola_2127	ENOG4105C3R	Methionine synthase
Tola_2128	ENOG4105CVG	Homoserine O-transsuccinylase
Tola_2129	ENOG4108I62	cina-like protein
Tola_2132	ENOG4108V1T	peptidylprolyl cis-trans isomerase
Tola_2133	ENOG4105VRX	Protein slyX homolog
Tola_2134	ENOG4105CX6	glutaminyL-tRNA synthetase
Tola_2135	ENOG4105CI1	PTS System
Tola_2136	ENOG4105CKA	Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity)
Tola_2137	ENOG4105CE4	GlcNAc 6-P deacetylase
Tola_2138	ENOG4105E2R	ROK family
Tola_2140	ENOG4105CVI	Transcriptional regulator
Tola_2141	ENOG4105ETE	Transcriptional regulator (LacI family
Tola_2142	ENOG4108HKT	sucrose-6-phosphate hydrolase
Tola_2143	ENOG4108RE9	Phosphodiesterase
Tola_2145	ENOG4105CE1	Ferrous iron transport protein b
Tola_2147	ENOG4105CQ2	DNA polymerase
Tola_2149	ENOG4107YBY	Hydrolase
Tola_2150	ENOG4107QZM	n-acetylglutamate synthase
Tola_2151	ENOG4105CFH	Aspartokinase
Tola_2153	ENOG4108UMN	azlc family
Tola_2154	ENOG4108Z7F	N-acetyltransferase
Tola_2156	ENOG4105CNN	ABC, transporter
Tola_2157	ENOG4105C2J	ABC transporter
Tola_2158	ENOG4105DMK	Periplasmic binding protein LacI transcriptional regulator
Tola_2160	ENOG4105EF1	ribulokinase
Tola_2162	ENOG4105CAC	Catalyzes the conversion of L-arabinose to L-ribulose (By similarity)
Tola_2163	ENOG4105CW3	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity)
Tola_2164	ENOG4105CV1	Transketolase (EC 2.2.1.1)
Tola_2165	ENOG4105D0C	transport protein
Tola_2167	ENOG4105XZD	Fe-S protein
Tola_2169	ENOG4105C2C	drug resistance transporter, Bcr CflA
Tola_2171	ENOG4105CM0	Catalyzes the synthesis of GMP from XMP (By similarity)
Tola_2172	ENOG4105CP4	Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity)
Tola_2173	ENOG4105DVS	Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity)
Tola_2174	ENOG4105NAU	thioesterase Superfamily protein
Tola_2175	ENOG4105EZI	multiple antibiotic resistance (MarC)-related protein
Tola_2176	ENOG4108EKI	Dehydrogenase
Tola_2177	ENOG4108DBC	nitroreductase
Tola_2178	ENOG4105EE5	Membrane protein terC
Tola_2179	ENOG4105D10	5-enolpyruvylshikimate-3-phosphate phospholyase
Tola_2180	ENOG4105C76	Specifically methylates the 50S ribosomal protein L3 on a specific glutamine residue (By similarity)
Tola_2181	ENOG4108DG9	Smr protein MutS2
Tola_2182	ENOG41061GZ	Protein of unknown function (DUF1107)
Tola_2183	ENOG4108BY2	phosphohistidine phosphatase
Tola_2184	ENOG4107QXK	peptidase
Tola_2185	ENOG4105F8V	Hydrolase, tatD family
Tola_2186	ENOG4107QRG	dna polymerase iii
Tola_2187	ENOG4108ZMD	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity)
Tola_2188	ENOG4105HHA	aminodeoxychorismate lyase
Tola_2190	ENOG4105C0Q	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity)
Tola_2191	ENOG4105VNB	Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity)
Tola_2192	ENOG4105CHR	reductase
Tola_2193	ENOG4105CJF	Malonyl coA-acyl carrier protein transacylase
Tola_2194	ENOG4105CCZ	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity)
Tola_2195	ENOG4105C6B	Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA (By similarity)
Tola_2196	ENOG4105VGS	50s ribosomal protein l32
Tola_2197	ENOG4105FCQ	metal-binding, possibly nucleic acid-binding protein
Tola_2198	ENOG4108UHJ	MAF-like protein
Tola_2199	ENOG4108VXP	Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity)
Tola_2200	ENOG4105EI2	Pseudouridine synthase
Tola_2201	ENOG4105C03	ribonuclease
Tola_2202	ENOG4105DS0	Transcriptional regulator, Crp Fnr family
Tola_2203	ENOG4105Q9Y	Universal stress protein
Tola_2204	ENOG4105CB3	Required for the thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32) (By similarity)
Tola_2207	ENOG4105EKD	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity)
Tola_2208	ENOG4105CAQ	asparagine synthetase
Tola_2210	ENOG41067MG	lrgb family
Tola_2212	ENOG4105CFX	Catalyzes the ferrous insertion into protoporphyrin IX (By similarity)
Tola_2213	ENOG4105CC8	Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity)
Tola_2214	ENOG4105CJX	Molecular chaperone. Has ATPase activity (By similarity)
Tola_2215	ENOG4105F3K	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity)
Tola_2216	ENOG4105KDX	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity)
Tola_2217	ENOG4107QMP	dna polymerase iii subunits gamma and tau
Tola_2218	ENOG4109003	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity)
Tola_2221	ENOG4107QQ4	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity)
Tola_2224	ENOG4105M2J	Glutaredoxin
Tola_2225	ENOG4105CK4	Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity)
Tola_2226	ENOG4105CH8	Succinyl-CoA ligase ADP-forming subunit alpha
Tola_2227	ENOG4105CMV	Succinyl-CoA synthetase subunit beta
Tola_2228	ENOG4105C7S	Dehydrogenase
Tola_2229	ENOG4105C7P	2-oxoglutarate dehydrogenase, E1
Tola_2230	ENOG4105BZN	citrate synthase
Tola_2231	ENOG4105CZI	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
Tola_2232	ENOG4105CET	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria (By similarity)
Tola_2233	ENOG4105W49	UPF0434 protein
Tola_2234	ENOG4105CHD	Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) (By similarity)
Tola_2236	ENOG4108EQH	DNA internalization-related competence protein ComEC Rec2
Tola_2237	ENOG4108VD1	dedA family
Tola_2238	ENOG4105D60	lipoprotein releasing system transmembrane protein
Tola_2239	ENOG4105CQU	Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity)
Tola_2240	ENOG4105D60	lipoprotein releasing system transmembrane protein
Tola_2241	ENOG4108JA2	transcriptioN-repair coupling factor
Tola_2242	ENOG4105C62	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity)
Tola_2243	ENOG4105K77	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity)
Tola_2244	ENOG4105D0T	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity)
Tola_2245	ENOG4105KG7	Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity)
Tola_2246	ENOG4107QHU	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity)
Tola_2247	ENOG4105CHV	Transcription elongation factor NusA
Tola_2248	ENOG4105K7D	Required for maturation of 30S ribosomal subunits (By similarity)
Tola_2250	ENOG4107QJF	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity)
Tola_2251	ENOG4105EEI	dihydropteroate synthase
Tola_2252	ENOG4105C3H	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity)
Tola_2253	ENOG4105F7M	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit (By similarity)
Tola_2254	ENOG4105HBR	Rna-binding protein
Tola_2255	ENOG4108UKH	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity)
Tola_2256	ENOG4105BZ5	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity)
Tola_2257	ENOG4105CFG	Acts as a chaperone (By similarity)
Tola_2258	ENOG4105K90	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
Tola_2259	ENOG4105F91	Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity)
Tola_2260	ENOG4105C4F	May be involved in recombinational repair of damaged DNA (By similarity)
Tola_2261	ENOG4105YRI	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity)
Tola_2262	ENOG4105VDB	UPF0125 protein
Tola_2263	ENOG4108Z1B	Cyclase dehydrase
Tola_2264	ENOG4108UH4	Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity)
Tola_2265	ENOG4105DFP	Integrase
Tola_2271	ENOG4107R3N	Filamentation induced by cAMP protein fic
Tola_2273	ENOG4105CVR	type I restriction-modification system
Tola_2275	ENOG4105H5P	transposase
Tola_2276	ENOG4108P8R	
Tola_2277	ENOG410679B	prophage CP4-57 regulatory protein alpA
Tola_2280	ENOG4108NF7	phage-type endonuclease
Tola_2294	ENOG4107Y2X	deaminase
Tola_2296	ENOG4108V7X	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
Tola_2297	ENOG4106F3G	Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5- dihydroxy-2-cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon (By similarity)
Tola_2298	ENOG4105BZS	acriflavin resistance protein
Tola_2300	ENOG4105DJ0	Poly(A) Polymerase
Tola_2301	ENOG4105K8U	2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
Tola_2302	ENOG4105CCG	Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity)
Tola_2303	ENOG4107R03	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity)
Tola_2304	ENOG4108Z2X	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine (By similarity)
Tola_2305	ENOG4108ZPD	The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity)
Tola_2306	ENOG4105C3G	gtp-binding protein
Tola_2307	ENOG4105C6N	Formate acetyltransferase
Tola_2308	ENOG4105F1A	Pyruvate formate-lyase
Tola_2309	ENOG4107T9Z	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity)
Tola_2310	ENOG4105CGR	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity)
Tola_2311	ENOG4105D1H	recombination factor protein RarA
Tola_2312	ENOG4107Y7W	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane) (By similarity)
Tola_2313	ENOG4105CNU	cell division protein FtsK
Tola_2314	ENOG4105EW9	transcriptional regulator AsnC family
Tola_2315	ENOG4105DCF	alanine dehydrogenase
Tola_2316	ENOG4105C3M	thioredoxin reductase
Tola_2317	ENOG4108R4Z	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine (By similarity)
Tola_2318	ENOG4105DWA	May conjugate Arg from its aminoacyl-tRNA to the N- termini of proteins containing an N-terminal aspartate or glutamate
Tola_2320	ENOG4105C2Z	ATP-dependent CLP protease ATP-binding subunit
Tola_2321	ENOG4105KAE	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation (By similarity)
Tola_2322	ENOG4105VEQ	Cold shock protein
Tola_2323	ENOG4108HMX	isocitrate dehydrogenase (NADP)
Tola_2325	ENOG4105CCJ	Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity)
Tola_2326	ENOG41075W9	High frequency lysogenization protein HflD homolog
Tola_2327	ENOG4107QTF	adenylosuccinate lyase
Tola_2329	ENOG4105DS4	PAS PAC sensor Signal transduction histidine kinase
Tola_2330	ENOG4105DGN	Electron transport complex
Tola_2331	ENOG4108R3D	Electron transport complex
Tola_2332	ENOG4107QTR	Required for nitrogen fixation. May be part of a membrane complex functioning as an intermediate in the electron transport to nitrogenase (By similarity)
Tola_2333	ENOG4105D6A	Electron transport complex
Tola_2334	ENOG4108UQQ	Electron transport complex
Tola_2335	ENOG4108E8M	Required for nitrogen fixation. May be part of a membrane complex functioning as an intermediate in the electron transport to nitrogenase (By similarity)
Tola_2336	ENOG4105VDB	UPF0125 protein
Tola_2339	ENOG4105DVH	amino acid
Tola_2342	ENOG4105XV5	nifz family
Tola_2345	ENOG4105C85	amino acid
Tola_2347	ENOG4105D6J	arsenicaL-resistance protein
Tola_2349	ENOG4105C17	glyceraldehyde-3-phosphate dehydrogenase
Tola_2350	ENOG4105EVE	HAD-superfamily hydrolase subfamily IA variant 3
Tola_2353	ENOG4105ET3	Reduction of activated sulfate into sulfite (By similarity)
Tola_2354	ENOG4105ET1	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity)
Tola_2355	ENOG4107EER	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity)
Tola_2357	ENOG4105C20	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity)
Tola_2358	ENOG4105BZU	Histidine kinase
Tola_2362	ENOG4105BZK	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair (By similarity)
Tola_2363	ENOG4105D3G	Pseudouridine synthase
Tola_2364	ENOG41066UG	Regulatory DnaK co-chaperone. Direct interaction between DnaK and DjlA is needed for the induction of the wcaABCDE operon, involved in the synthesis of a colanic acid polysaccharide capsule, possibly through activation of the RcsB RcsC phosphotransfer signaling pathway. The colanic acid capsule may help the bacterium survive conditions outside the host (By similarity)
Tola_2365	ENOG4108S0S	Nucleotidyl transferase
Tola_2366	ENOG4105EHM	Aminoglycoside phosphotransferase
Tola_2367	ENOG4105E7H	involved in the assembly of LPS in the outer leaflet of the outer membrane. Determines N-hexane tolerance and is involved in outer membrane permeability. Essential for envelope biogenesis (By similarity)
Tola_2368	ENOG4105DBD	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation (By similarity)
Tola_2369	ENOG4105CEZ	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) (By similarity)
Tola_2370	ENOG4105D1X	Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity)
Tola_2371	ENOG4105NWN	ApaG protein
Tola_2372	ENOG4105DDT	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity)
Tola_2374	ENOG4107XM3	UPF0442 protein
Tola_2375	ENOG4105DWK	Membrane
Tola_2376	ENOG4105DR8	Membrane
Tola_2377	ENOG4105C9R	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
Tola_2378	ENOG4105K46	50S ribosomal protein l27
Tola_2379	ENOG4105KK9	This protein binds to 23S rRNA in the presence of protein L20 (By similarity)
Tola_2380	ENOG4105EAH	synthase
Tola_2381	ENOG4105C91	Plays an important role in the de novo pathway of purine nucleotide biosynthesis
Tola_2382	ENOG4105EPW	hflc protein
Tola_2383	ENOG4107QJR	hflk protein
Tola_2384	ENOG4105C1N	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity)
Tola_2385	ENOG4105KW8	RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity)
Tola_2386	ENOG4105DKX	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity)
Tola_2387	ENOG4105DC6	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity)
Tola_2388	ENOG4105C5C	n-acetylmuramoyl-l-alanine amidase
Tola_2389	ENOG4105K8N	protein family UPF0079, ATPase
Tola_2390	ENOG4105DR1	Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity)
Tola_2393	ENOG4107QJR	hflk protein
Tola_2396	ENOG4107QJE	Chromosome Partitioning Protein
Tola_2403	ENOG4107YH6	single-stranded DNA-binding protein
Tola_2404	ENOG4105C73	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity)
Tola_2446	ENOG4105W5Q	DNA repair protein (RadC
Tola_2453	ENOG4108R8Z	these effects are overcome by concomitant expression of antitoxin SohA (PrlF). Massive overexpression is toxic. Unlike most other characterized TA systems degrades rRNA, and co-folding of the proteins is necessary in vitro for inhibition of the RNase activity. It is not known if it has any sequence-specificity. Acts as a transcription factor. The YhaV PrlF complex binds the prlF-yhaV operon, probably negatively regulating its expression
Tola_2457	ENOG4105C5B	carbamate kinase
Tola_2459	ENOG4105CEU	Arginine dihydrolase
Tola_2460	ENOG4105CSX	c4-dicarboxylate anaerobic carrier
Tola_2464	ENOG4105ENJ	RND efflux system, outer membrane lipoprotein
Tola_2465	ENOG4105D0S	secretion protein (HlyD
Tola_2466	ENOG4105CJ1	ABC, transporter
Tola_2467	ENOG4105CMI	transporter
Tola_2469	ENOG4105CHR	reductase
Tola_2473	ENOG4105C6H	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity)
Tola_2474	ENOG4105D6U	Sodium Glutamate Symporter
Tola_2475	ENOG4105D1N	poly(r)-hydroxyalkanoic acid synthase, class
Tola_2476	ENOG41081QV	Universal stress protein
Tola_2479	ENOG4105C5T	Phosphoribosyl pyrophosphate synthase
Tola_2481	ENOG4105CY0	Metallo-Beta-Lactamase
Tola_2482	ENOG4105CMW	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity)
Tola_2483	ENOG4106NZI	LysR family Transcriptional regulator
Tola_2487	ENOG4108RBP	3'-to-5' exoribonuclease specific for small oligoribonucleotides (By similarity)
Tola_2488	ENOG4105E06	May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity)
Tola_2489	ENOG4105DJ4	phosphatidylserine decarboxylase
Tola_2490	ENOG4105C00	Succinate dehydrogenase (Flavoprotein subunit)
Tola_2491	ENOG4105E33	succinate dehydrogenase
Tola_2492	ENOG4108WJH	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane (By similarity)
Tola_2493	ENOG4108VP9	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane (By similarity)
Tola_2494	ENOG4105CP4	Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity)
Tola_2496	ENOG4105EIZ	Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity)
Tola_2497	ENOG4105K9Q	Binds to the 23S rRNA (By similarity)
Tola_2498	ENOG4105VH8	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity)
Tola_2499	ENOG4108ZDX	Binds together with S18 to 16S ribosomal RNA (By similarity)
Tola_2500	ENOG4107QXP	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity)
Tola_2501	ENOG4105EIP	mannose-6-phosphate isomerase
Tola_2502	ENOG4105D8I	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS (By similarity)
Tola_2503	ENOG41067QG	Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity)
Tola_2504	ENOG4105CTB	Polyprenyl synthetase
Tola_2505	ENOG4105C2V	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity)
Tola_2508	ENOG4105RK9	auxin efflux carrier
Tola_2510	ENOG4105C2T	Binding-protein-dependent transport systems, inner membrane component
Tola_2511	ENOG4105CJM	Binding-protein-dependent transport systems, inner membrane component
Tola_2519	ENOG4108ZAI	phosphatidylglycerophosphatase a
Tola_2520	ENOG4105CG2	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity)
Tola_2521	ENOG4107YIM	Involved in the transcription termination process (By similarity)
Tola_2522	ENOG4108UTT	Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity)
Tola_2525	ENOG4105D1W	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity)
Tola_2526	ENOG4108Z11	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity)
Tola_2527	ENOG4105C65	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity)
Tola_2528	ENOG4108Z38	Catalyzes a trans-dehydration via an enolate intermediate (By similarity)
Tola_2529	ENOG4105KM4	Acetyl-CoA carboxylase, biotin carboxyl carrier protein
Tola_2530	ENOG4105CER	acetyl-CoA carboxylase biotin carboxylase
Tola_2532	ENOG4105F59	Methylates ribosomal protein L11 (By similarity)
Tola_2533	ENOG4105CEH	Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity)
Tola_2534	ENOG4105VY0	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters (By similarity)
Tola_2535	ENOG4108I6E	Sulfatase
Tola_2536	ENOG4105DKW	ABC transporter
Tola_2539	ENOG4108UMA	3-octaprenyl-4-hydroxybenzoate carboxy-lyase
Tola_2540	ENOG4105DFU	Cell wall formation (By similarity)
Tola_2541	ENOG4105F0N	pyrophosphate phospho-hydrolase
Tola_2543	ENOG4108I67	Catalyzes the synthesis of activated sulfate (By similarity)
Tola_2544	ENOG4105C3T	may be the GTPase, regulating ATP sulfurylase activity (By similarity)
Tola_2545	ENOG4105C11	sulfate adenylyltransferase), subunit 2
Tola_2546	ENOG4105CB8	Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity)
Tola_2547	ENOG4107QX8	SPFH domain, Band 7 family protein
Tola_2548	ENOG4105G5H	Membrane
Tola_2549	ENOG4105C80	Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity)
Tola_2550	ENOG410682Y	Regulates arginine biosynthesis genes (By similarity)
Tola_2551	ENOG4105CEQ	signal transduction histidine kinase regulating citrate malate metabolism
Tola_2552	ENOG4107GFK	fumarate
Tola_2556	ENOG4108MRH	transcriptional regulatory protein
Tola_2557	ENOG4105C53	Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity)
Tola_2560	ENOG4108YZA	Nitrogen regulatory protein pii
Tola_2561	ENOG4108ZIG	UPF0231 protein
Tola_2562	ENOG4107QIJ	Aconitate hydratase 2
Tola_2564	ENOG4107Z6W	Protein CrcB homolog
Tola_2566	ENOG4107SA8	fad-dependent pyridine nucleotide-disulfide oxidoreductase
Tola_2572	ENOG4107SQD	Transcriptional regulator, GntR family
Tola_2573	ENOG4105CF3	3-Hydroxyisobutyrate dehydrogenase
Tola_2574	ENOG4107QN2	dihydrolipoyl dehydrogenase
Tola_2575	ENOG4107QSN	dihydrolipoamide acetyltransferase
Tola_2576	ENOG4105DAQ	Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity)
Tola_2577	ENOG41073TP	transcriptional regulator
Tola_2578	ENOG4108IXP	Carbohydrate diacid transcriptional activator CdaR
Tola_2579	ENOG4105BZW	Glycerate kinase
Tola_2580	ENOG4105CF3	3-Hydroxyisobutyrate dehydrogenase
Tola_2581	ENOG4105CNV	Aldolase
Tola_2582	ENOG4105EQX	glucarate dehydratase
Tola_2583	ENOG4105EQX	glucarate dehydratase
Tola_2584	ENOG4105DJB	Major Facilitator Superfamily
Tola_2585	ENOG4105CTX	dehydratase
Tola_2586	ENOG4108VBV	N-Acetylmuramoyl-L-alanine amidase
Tola_2587	ENOG4105D18	nicotinate-nucleotide pyrophosphorylase
Tola_2588	ENOG410667J	hydrolase
Tola_2589	ENOG4105BZG	amino acid carrier protein
Tola_2590	ENOG4105K70	DNA-binding protein
Tola_2592	ENOG4105DR5	peptidase
Tola_2593	ENOG4105CFZ	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity)
Tola_2594	ENOG4108ZVW	Anti-RNA polymerase sigma 70 factor
Tola_2595	ENOG4105DNJ	May play a role in the repair of endogenous alkylation damage (By similarity)
Tola_2596	ENOG4105EAC	phosphoserine phosphatase
Tola_2597	ENOG4105D3A	purine nucleoside phosphorylase DeoD-type
Tola_2598	ENOG4105CZG	Phosphotransfer between the C1 and C5 carbon atoms of pentose (By similarity)
Tola_2599	ENOG4105CMW	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity)
Tola_2600	ENOG4105FCI	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity)
Tola_2601	ENOG4105EYA	deoxyribonuclease
Tola_2603	ENOG4105C8A	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP (By similarity)
Tola_2605	ENOG4105C2N	RNA methyltransferase TrmH family group 3
Tola_2606	ENOG4105C40	3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity)
Tola_2611	ENOG4105C31	Tryptophanyl-tRNA synthetase
Tola_2612	ENOG4108VXP	Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity)
Tola_2613	ENOG4105DJV	ribulose-phosphate 3-epimerase
Tola_2614	ENOG4105DFE	Dna adenine methylase
Tola_2616	ENOG4105D49	3-dehydroquinate synthase
Tola_2617	ENOG4105KHV	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity)
Tola_2618	ENOG4105CDP	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity)
Tola_2619	ENOG4107VXZ	Hydrolase
Tola_2620	ENOG4105KW8	RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity)
Tola_2622	ENOG4108JQC	penicillin-binding protein 1A
Tola_2627	ENOG4105E4G	Type IV pilus
Tola_2628	ENOG4105D8J	Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle (By similarity)
Tola_2629	ENOG4107QQ4	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity)
Tola_2630	ENOG4105CXW	Synthesizes alpha-1,4-glucan chains using ADP-glucose (By similarity)
Tola_2631	ENOG4105BZT	Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity)
Tola_2632	ENOG4105ENN	converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity)
Tola_2633	ENOG4105CRD	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity)
Tola_2634	ENOG4105F0Z	galactose-1-phosphate uridylyltransferase
Tola_2635	ENOG4105CMR	udp-glucose 4-epimerase
Tola_2636	ENOG41060NJ	transcriptional regulator
Tola_2637	ENOG4107SDZ	Galactoside transport system permease protein mglC
Tola_2638	ENOG4105C2J	ABC transporter
Tola_2640	ENOG4105KWU	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
Tola_2641	ENOG4105ES3	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
Tola_2642	ENOG4105CQV	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
Tola_2643	ENOG4105GKE	subunit e
Tola_2644	ENOG4107QIZ	NADH dehydrogenase
Tola_2645	ENOG4108IEH	NADH dehydrogenase subunit g
Tola_2646	ENOG4105CMZ	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone (By similarity)
Tola_2647	ENOG4105P3U	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
Tola_2648	ENOG4107UFS	subunit j
Tola_2649	ENOG41080EA	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
Tola_2650	ENOG4105D65	subunit l
Tola_2651	ENOG4105C8S	subunit m
Tola_2652	ENOG4105CNR	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
Tola_2653	ENOG4105FDP	GntR family transcriptional regulator
Tola_2654	ENOG4108I6A	alcohol dehydrogenase
Tola_2655	ENOG4105F8D	glycoside hydrolase family 4
Tola_2656	ENOG4105CI1	PTS System
Tola_2657	ENOG4105C9X	ppx gppa phosphatase
Tola_2658	ENOG4105C1J	atp-dependent rna helicase
Tola_2659	ENOG4105K63	Thioredoxin
Tola_2660	ENOG4105C4P	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity)
Tola_2664	ENOG4105D4J	Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate
Tola_2666	ENOG4107ZVW	dihydroneopterin aldolase
Tola_2667	ENOG4105K7Z	Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity)
Tola_2668	ENOG4105CPM	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity)
Tola_2669	ENOG4105VCC	30S ribosomal protein S21
Tola_2670	ENOG4105C9G	DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity)
Tola_2671	ENOG4105DG1	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity)
Tola_2679	ENOG4105XB7	anti-repressor protein
Tola_2682	ENOG4105DFP	Integrase
Tola_2683	ENOG4105D70	Integrase catalytic subunit
Tola_2684	ENOG4105F5W	AtP-binding protein
Tola_2687	ENOG4105RKW	reductase (By
Tola_2688	ENOG4106HRJ	d-alanyl-d-alanine carboxypeptidase
Tola_2689	ENOG4105CHM	Aminotransferase
Tola_2690	ENOG4105DK2	UPF0207 protein
Tola_2691	ENOG41069NU	Nitroreductase
Tola_2692	ENOG4105D07	Signal peptide peptidase, SppA
Tola_2693	ENOG4105HDK	L-asparaginase
Tola_2694	ENOG4105E0X	reductase
Tola_2696	ENOG4105C9C	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity)
Tola_2697	ENOG4107RTM	4-alpha-glucanotransferase (EC 2.4.1.25)
Tola_2698	ENOG4105C17	glyceraldehyde-3-phosphate dehydrogenase
Tola_2699	ENOG4105DSB	aldose 1-epimerase
Tola_2700	ENOG4105D0I	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity)
Tola_2702	ENOG4105KCK	Peptidoglycan-associated lipoprotein
Tola_2703	ENOG4107R6Y	Involved in the TonB-independent uptake of proteins (By similarity)
Tola_2704	ENOG4108Z82	Cell envelope integrity inner membrane protein TolA
Tola_2705	ENOG4105M8F	Biopolymer transport protein exbD tolR
Tola_2706	ENOG4105E02	MotA TolQ exbB proton channel
Tola_2707	ENOG4107YD3	Thioesterase
Tola_2709	ENOG4105CFY	cytochrome d ubiquinol oxidase, subunit ii
Tola_2710	ENOG4105C4M	(Ubiquinol oxidase) subunit I
Tola_2711	ENOG4105CKJ	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity)
Tola_2712	ENOG4105KA4	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity)
Tola_2713	ENOG4105NHU	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group (By similarity)
Tola_2714	ENOG4105CDY	transcriptional regulatory protein
Tola_2715	ENOG4105C9M	aspartyl-trna synthetase
Tola_2717	ENOG4105CIW	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity)
Tola_2718	ENOG4105C9A	Phoh family
Tola_2719	ENOG4105KGE	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity)
Tola_2720	ENOG4108JU5	Magnesium and cobalt efflux protein
Tola_2721	ENOG4105CE8	Transfers the fatty acyl group on membrane lipoproteins (By similarity)
Tola_2722	ENOG4107URF	beta-phospho-glucomutase
Tola_2724	ENOG4105CEH	Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity)
Tola_2726	ENOG4105CJ4	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity)
Tola_2727	ENOG4105CDU	Replicative dna helicase
Tola_2728	ENOG4105VM8	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding (By similarity)
Tola_2729	ENOG4105CIM	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity)
Tola_2730	ENOG4105Y3E	Modulates RecA activity (By similarity)
Tola_2731	ENOG4105C68	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity)
Tola_2732	ENOG4107TH8	cina domain protein
Tola_2733	ENOG4105D86	that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity)
Tola_2735	ENOG4108K5P	(LipO)protein
Tola_2736	ENOG4105E26	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity)
Tola_2737	ENOG4105CV2	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates (By similarity)
Tola_2738	ENOG4106NZV	Responsible for synthesis of pseudouridine from uracil- 13 in transfer RNAs (By similarity)
Tola_2739	ENOG4108UH8	Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity)
Tola_2740	ENOG4105CE5	Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity)
Tola_2741	ENOG4105XX3	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic (By similarity)
Tola_2742	ENOG4105C70	Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity)
Tola_2743	ENOG4105C8D	Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity)
Tola_2744	ENOG4105DXN	mazG family
Tola_2745	ENOG4105CWR	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity)
Tola_2746	ENOG4105BZT	Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity)
Tola_2747	ENOG4105BZU	Histidine kinase
Tola_2750	ENOG4107SQD	Transcriptional regulator, GntR family
Tola_2751	ENOG4105YP7	UPF0270 protein
Tola_2753	ENOG4105C8Y	Acetylornithine aminotransferase
Tola_2754	ENOG4105DDQ	anthranilate synthase
Tola_2755	ENOG4105K5B	UPF0225 protein
Tola_2756	ENOG4105DDT	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity)
Tola_2758	ENOG4108YYX	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome. Modulates RNA-binding and helicase activities of the degradosome (By similarity)
Tola_2759	ENOG41065UX	Non-essential, abundant cell division factor that is required for proper Z-ring formation. It is recruited early to the divisome by direct interaction with FtsZ, stimulating Z-ring assembly and thereby promoting cell division earlier in the cell cycle. Its recruitment to the Z-ring requires functional FtsA or ZipA (By similarity)
Tola_2761	ENOG4105D7W	serine acetyltransferase
Tola_2762	ENOG41076HS	cation diffusion facilitator family transporter
Tola_2763	ENOG4105D38	putrescine abc transporter
Tola_2764	ENOG4105F38	ABC transporter, permease
Tola_2765	ENOG4105C53	Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity)
Tola_2766	ENOG4107RUE	extracellular solute-binding protein family 1
Tola_2767	ENOG4108RH0	Crea protein
Tola_2769	ENOG4105C2Z	ATP-dependent CLP protease ATP-binding subunit
Tola_2770	ENOG4105DBW	Multi-copper polyphenol oxidoreductase laccase
Tola_2771	ENOG4105C34	Pseudouridine synthase
Tola_2772	ENOG4106SNF	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
Tola_2773	ENOG4108Z5K	methylglyoxal synthase
Tola_2774	ENOG4105CGV	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity)
Tola_2775	ENOG4105CEJ	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity)
Tola_2776	ENOG4108UHY	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity)
Tola_2777	ENOG4108UKE	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity)
Tola_2780	ENOG4108ZAT	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE (By similarity)
Tola_2782	ENOG4105D27	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
Tola_2783	ENOG4107QIH	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
Tola_2784	ENOG4105KBC	Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity)
Tola_2785	ENOG4108VZM	50s ribosomal protein L10
Tola_2786	ENOG4105C64	Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity)
Tola_2787	ENOG4108UIK	This protein binds directly to 23S ribosomal RNA (By similarity)
Tola_2788	ENOG4105E5V	Participates in transcription elongation, termination and antitermination (By similarity)
Tola_2789	ENOG4105PM1	preprotein translocase subunit SecE
Tola_2790	ENOG4105CGV	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity)
Tola_2791	ENOG4105CS9	pantothenic acid kinase
Tola_2792	ENOG4105HJX	Biotin- acetyl-CoA-carboxylase ligase
Tola_2793	ENOG4105D4A	Cell wall formation (By similarity)
Tola_2794	ENOG4105CB9	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
Tola_2795	ENOG4106KVJ	cytochrome C assembly protein
Tola_2796	ENOG4105C15	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity)
Tola_2797	ENOG4108IIE	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity)
Tola_2798	ENOG4105DR5	peptidase
Tola_2799	ENOG4105KEG	ribosomal-protein-alanine acetyltransferase
Tola_2801	ENOG4107R4Q	Functions as an ATPase. May play a role in metal insertion (metal-chelatase) or as a chaperone (By similarity)
Tola_2802	ENOG4105EV2	VWA domain protein interacting with AAA ATPase
Tola_2803	ENOG4105CXT	aspartate transcarbamylase
Tola_2804	ENOG4108R9M	Involved in allosteric regulation of aspartate carbamoyltransferase (By similarity)
Tola_2805	ENOG4105C2C	drug resistance transporter, Bcr CflA
Tola_2806	ENOG4105CKD	glutathione-regulated potassium-efflux system protein
Tola_2807	ENOG4108ZMA	Outer membrane lipoprotein
Tola_2808	ENOG41066DY	Membrane
Tola_2809	ENOG4108UPT	UPF0178 protein
Tola_2810	ENOG4105CFP	Peptidase U32
Tola_2811	ENOG4105BZU	Histidine kinase
Tola_2813	ENOG4105CJ9	Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity)
Tola_2814	ENOG4105K5Y	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity)
Tola_2816	ENOG4105VF7	tolerance protein
Tola_2819	ENOG4105C8J	)-transporter
Tola_2821	ENOG41061WM	D-Alanyl-D-Alanine
Tola_2823	ENOG4105C8T	Leucyl-tRNA synthetase
Tola_2825	ENOG4105DJF	DNA polymerase III, delta' subunit
Tola_2826	ENOG4105KEM	Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation (By similarity)
Tola_2827	ENOG4108UXA	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity)
Tola_2828	ENOG4105CJN	penicillin-binding protein
Tola_2829	ENOG4105CNI	cell division protein FtsW
Tola_2830	ENOG4105CVE	Lytic murein transglycosylase
Tola_2831	ENOG4105K6T	rare lipoprotein A
Tola_2832	ENOG4105K6T	rare lipoprotein A
Tola_2833	ENOG4105DZ1	carboxypeptidase
Tola_2834	ENOG4108Z43	UPF0250 protein
Tola_2835	ENOG4108BDP	Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity)
Tola_2836	ENOG4105C0G	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity)
Tola_2837	ENOG4107GZ4	SanA protein
Tola_2839	ENOG4105BZU	Histidine kinase
Tola_2851	ENOG4105K4U	addiction module toxin, RelE StbE family
Tola_2855	ENOG4107QJF	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity)
Tola_2860	ENOG4105H63	Glycosyl transferase, family 2
Tola_2861	ENOG4105H63	Glycosyl transferase, family 2
Tola_2862	ENOG4107T8Q	Glycosyl transferase (Group 1
Tola_2864	ENOG4108MX3	Polysaccharide Biosynthesis Protein
Tola_2865	ENOG4105ESV	Glycosyl transferase, family 4
Tola_2866	ENOG4105D75	Capsular exopolysaccharide family
Tola_2867	ENOG4105KJF	protein tyrosine phosphatase
Tola_2868	ENOG4105DAY	polysaccharide export protein
Tola_2871	ENOG4105C8E	extradiol ring-cleavage dioxygenase class IIi protein subunit b
Tola_2877	ENOG4105CC0	LysR family Transcriptional regulator
Tola_2879	ENOG4108R5S	membrane
Tola_2882	ENOG4105D2H	Uronic isomerase
Tola_2883	ENOG4105DEI	Mannitol dehydrogenase
Tola_2884	ENOG4105CHZ	Catalyzes the dehydration of D-mannonate (By similarity)
Tola_2885	ENOG4105DPW	Major facilitator superfamily MFS_1
Tola_2887	ENOG4105C6F	GntR Family Transcriptional Regulator
Tola_2890	ENOG4108QNI	outer membrane porin protein
Tola_2891	ENOG4105CT4	transporter
Tola_2895	ENOG4105CT4	transporter
Tola_2896	ENOG4105CNT	hydrolase family 2
Tola_2897	ENOG4107RSM	transcriptional regulator
Tola_2899	ENOG4105CER	acetyl-CoA carboxylase biotin carboxylase
Tola_2902	ENOG4105C53	Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity)
Tola_2905	ENOG4107YBY	Hydrolase
Tola_2907	ENOG410624X	efflux transporter, rnd family, mfp subunit
Tola_2908	ENOG4105BZS	acriflavin resistance protein
Tola_2909	ENOG4105BZG	amino acid carrier protein
Tola_2911	ENOG4105CE6	Adenylation and deadenylation of glutamate--ammonia ligase (By similarity)
Tola_2912	ENOG4105MYN	Zinc uptake regulation protein
Tola_2913	ENOG4105DIK	(ABC) transporter
Tola_2914	ENOG4105CC5	ABC transporter
Tola_2915	ENOG4105DSE	periplasmic solute binding protein
Tola_2916	ENOG4105EUB	pirin domain protein
Tola_2917	ENOG4105KQT	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome (By similarity)
Tola_2918	ENOG4106762	Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5- dihydroxy-2,3-pentadione (DPD) (By similarity)
Tola_2920	ENOG4108YZA	Nitrogen regulatory protein pii
Tola_2921	ENOG4108UJD	30S ribosomal protein S9
Tola_2922	ENOG4108UM5	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity)
Tola_2924	ENOG4105C0H	protease
Tola_2925	ENOG4105C0H	protease
Tola_2926	ENOG4105CDF	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity)
Tola_2927	ENOG4105VFK	BolA family
Tola_2929	ENOG4105E3I	toluene tolerance
Tola_2930	ENOG4107PE3	Mammalian cell entry related domain protein
Tola_2931	ENOG4105CY3	ABC transporter, permease
Tola_2932	ENOG4105DHJ	ABC, transporter
Tola_2933	ENOG4105C2X	Arabinose 5-phosphate isomerase
Tola_2936	ENOG4105WI0	lipopolysaccharide transport periplasmic protein lptA
Tola_2937	ENOG4108IUZ	ABC transporter
Tola_2938	ENOG4105DTW	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity)
Tola_2939	ENOG41080QH	sigma 54 modulation protein ribosomal protein S30EA
Tola_2940	ENOG4107RM2	PTS IIA-like nitrogen-regulatory protein PtsN
Tola_2941	ENOG4105C21	Displays ATPase and GTPase activities (By similarity)
Tola_2942	ENOG41080Z8	PHOSPHOCARRIER protein
Tola_2943	ENOG4105DZ2	Transcriptional regulator
Tola_2945	ENOG4105C3B	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity)
Tola_2951	ENOG4106855	Competence protein
Tola_2952	ENOG4105C48	Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity)
Tola_2953	ENOG4105M02	This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity)
Tola_2954	ENOG4105C07	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity)
Tola_2955	ENOG4105DTN	riboflavin biosynthesis protein ribF
Tola_2956	ENOG4105CJR	Integral membrane protein (MviN
Tola_2957	ENOG4105KQV	Binds directly to 16S ribosomal RNA (By similarity)
Tola_2958	ENOG41080HT	Transcriptional regulator, arsr family
Tola_2959	ENOG41063Z6	transcriptional regulator, lysR family
Tola_2960	ENOG4105DRC	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity)
Tola_2961	ENOG4105C0V	Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity)
Tola_2962	ENOG4108HRM	phosphoenolpyruvate--protein phosphotransferase
Tola_2963	ENOG4105EJF	Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity)
Tola_2964	ENOG4105IRT	Sequence-specific endonuclease that cleaves unmethylated GATC sequences. It is involved in DNA mismatch repair (By similarity)
Tola_2966	ENOG4108YY1	This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity)
Tola_2967	ENOG4105D6X	Specifically methylates guanosine-37 in various tRNAs (By similarity)
Tola_2968	ENOG4108ZR6	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity)
Tola_2969	ENOG4105K5M	30s ribosomal protein S16
Tola_2970	ENOG4105VFU	Rna-binding protein
Tola_2972	ENOG4105E27	serine threonine protein kinase
Tola_2973	ENOG4105PC1	Conserved Protein
Tola_2974	ENOG4105FE1	phytoene synthase
Tola_2975	ENOG4105D3H	Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity)
Tola_2976	ENOG4107QK7	reductase
Tola_2977	ENOG4105W0Z	cytoplasmic protein
Tola_2978	ENOG4105C9U	ATP-dependent DNA helicase RecQ
Tola_2980	ENOG4105FR1	rard protein
Tola_2982	ENOG4105CK1	PTS System
Tola_2983	ENOG4105VCP	PTS System
Tola_2984	ENOG4105CS2	ec 3.2.1.21
Tola_2986	ENOG41060NJ	transcriptional regulator
Tola_2987	ENOG4108IJF	Heavy metal efflux pump, CzcA
Tola_2988	ENOG4105EP1	Efflux transporter rnd family, mfp subunit
Tola_2991	ENOG4105EFU	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin (By similarity)
Tola_2993	ENOG4105DWQ	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity)
Tola_2994	ENOG4108J5C	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity)
Tola_2995	ENOG4106I92	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity)
Tola_2996	ENOG4105F5D	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity)
Tola_2997	ENOG4108IUB	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity)
Tola_2998	ENOG4105D26	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. The first step is catalyzed by NqrF, which accepts electrons from NADH and reduces ubiquinone-1 to ubisemiquinone by a one-electron transfer pathway (By similarity)
Tola_3000	ENOG4105FFN	Specifically methylates the guanosine in position 1516 of 16S rRNA (By similarity)
Tola_3001	ENOG4105DGW	oligopeptidase A
Tola_3002	ENOG4105DC7	peptidase M24
Tola_3003	ENOG4105JIM	Phosphatidylserine synthase
Tola_3005	ENOG4105CK7	Sodium proline symporter
Tola_3006	ENOG4108IJ0	Aspartate ammonia-lyase
Tola_3007	ENOG4105CCX	Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity)
Tola_3009	ENOG41077A9	carbonic anhydrase
Tola_3011	ENOG4105CRP	Part of the ABC transporter FtsEX involved in
Tola_3012	ENOG4105CAK	Cell division ATP-binding protein ftsE
Tola_3013	ENOG4105CCP	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC)
Tola_3014	ENOG4106H78	methyltransferase
Tola_3016	ENOG4108IEC	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction (By similarity)
Tola_3017	ENOG4105E0F	Histidine kinase
Tola_3018	ENOG4105DPZ	Two component transcriptional regulator (Winged helix family
Tola_3020	ENOG4105E0I	Catalyzes the formation of N(4)-acetylcytidine (ac(4)C) at the wobble position of tRNA(Met), by using acetyl-CoA as an acetyl donor and ATP (or GTP) (By similarity)
Tola_3021	ENOG4108ZI0	d,d-heptose 1,7-bisphosphate phosphatase
Tola_3022	ENOG4108Z33	Thiol disulfide Interchange Protein
Tola_3024	ENOG4105DPW	Major facilitator superfamily MFS_1
Tola_3026	ENOG4107QZW	Altronate oxidoreductase
Tola_3027	ENOG4105CTX	dehydratase
Tola_3028	ENOG4105P66	Membrane
Tola_3035	ENOG4105M03	Domain of unknown function (DUF955)
Tola_3038	ENOG4107TSN	permease
Tola_3041	ENOG4107RAQ	aminopeptidase
Tola_3043	ENOG4105CAX	The 2-keto-3-deoxygluconate permease transports the degraded pectin products into the bacterial cell, where they serve as carbon and energy sources. This is a hydrogen coupled transport system (By similarity)
Tola_3044	ENOG4105XEP	YhcH YjgK YiaL family protein
Tola_3046	ENOG4107SS6	2-dehydro-3-deoxygluconokinase
Tola_3047	ENOG4108UHU	Aldolase
Tola_3048	ENOG4105D50	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate (By similarity)
Tola_3049	ENOG4105CHR	reductase
Tola_3050	ENOG4105EP9	oxidoreductase
Tola_3051	ENOG4106HNH	Acyl-transferase
Tola_3052	ENOG4105C7R	Atpase associated with various cellular activities aaa_3
Tola_3054	ENOG4105F8C	transglutaminase domain-containing protein
Tola_3057	ENOG4105G6Z	alkaline phosphatase
Tola_3059	ENOG4105C0P	Mg chelatase subunit ChlI
Tola_3060	ENOG4105IGJ	Zn-dependent Hydrolase of the beta-lactamase fold protein
Tola_3062	ENOG4105DW5	Transcriptional regulator
Tola_3063	ENOG41064BZ	L-xylulose 5-phosphate 3-epimerase
Tola_3064	ENOG4108K4B	hydrolase
Tola_3067	ENOG4108XBJ	The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane (By similarity)
Tola_3068	ENOG4107R0P	L-ribulose-5-phosphate 4-epimerase
Tola_3070	ENOG4105CW3	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity)
Tola_3071	ENOG4105CV1	Transketolase (EC 2.2.1.1)
Tola_3083	ENOG4105DKT	Transcriptional regulator
Tola_3084	ENOG4105DEI	Mannitol dehydrogenase
Tola_3085	ENOG4105CMG	Carbohydrate kinase
Tola_3086	ENOG4105IE8	Alpha-ketoglutarate permease
Tola_3087	ENOG4105CW3	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity)
Tola_3088	ENOG4105CV1	Transketolase (EC 2.2.1.1)
Tola_3089	ENOG4105D9I	Responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6 (By similarity)
Tola_3091	ENOG4105P3Y	Acetolactate synthase 2 regulatory subunit
Tola_3092	ENOG4105CM2	brancheD-chain amino acid aminotransferase
Tola_3093	ENOG4105C01	Dihydroxy-acid dehydratase
Tola_3094	ENOG4105C7B	Threonine dehydratase
Tola_3098	ENOG4105G2Y	Transcriptional regulator
Tola_3099	ENOG4105C0R	drug resistance transporter emrb qaca subfamily
Tola_3100	ENOG4105DDV	Transcriptional regulator (LacI family
Tola_3101	ENOG4105CS2	ec 3.2.1.21
Tola_3102	ENOG4105VCP	PTS System
Tola_3103	ENOG4105CK1	PTS System
Tola_3104	ENOG4105VZJ	PTS System
Tola_3105	ENOG4105CS2	ec 3.2.1.21
Tola_3106	ENOG4105C5Y	PTS System
Tola_3107	ENOG4105EBR	Carboxylesterase
Tola_3110	ENOG4108UQY	Iron-storage protein
Tola_3112	ENOG4105BZU	Histidine kinase
Tola_3113	ENOG4105CFI	type iii restriction protein res subunit
Tola_3114	ENOG41061P8	Persistence to inhibition of murein or DNA biosynthesis regulatory protein
Tola_3115	ENOG4105CAF	HipA N-terminal domain protein
Tola_3116	ENOG4105C0Y	Responsible for the amidation of carboxylic groups at position A and C of either cobyrinic acid or hydrogenobrynic acid. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity)
Tola_3117	ENOG4105CAA	catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity)
Tola_3118	ENOG4105YES	addiction module antidote protein
Tola_3119	ENOG4108IYS	Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity)
Tola_3120	ENOG4105CT0	Protein of unknown function, DUF484
Tola_3121	ENOG4105E4Z	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity)
Tola_3122	ENOG4105CU5	Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity)
Tola_3123	ENOG4105XQ6	frataxin-like protein
Tola_3126	ENOG4107T0K	Adenylate cyclase
Tola_3127	ENOG4105D6W	Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity)
Tola_3128	ENOG41076E6	Uroporphyrinogen-III Synthase
Tola_3129	ENOG4105ECF	c-methyltransferase
Tola_3130	ENOG410601J	HemY protein
Tola_3132	ENOG4105KNM	Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity)
Tola_3133	ENOG4105C4J	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity)
Tola_3134	ENOG4105J80	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity)
Tola_3135	ENOG4105CDG	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity)
Tola_3136	ENOG4107S15	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity)
Tola_3137	ENOG4107Z6K	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity)
Tola_3138	ENOG4105KY6	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity)
Tola_3139	ENOG4105EE4	it plays a direct role in the translocation of protons across the membrane (By similarity)
Tola_3141	ENOG4105FA0	parb-like partition protein
Tola_3142	ENOG4107QJE	Chromosome Partitioning Protein
Tola_3143	ENOG4105D28	Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity)
Tola_3144	ENOG4107RE5	NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity)
Tola_3146	ENOG4105QTB	Flavodoxin
Tola_3147	ENOG4105DRH	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity)
Tola_3150	ENOG4105IPI	Membrane
Tola_3151	ENOG4105CC0	LysR family Transcriptional regulator
Tola_3153	ENOG4105VRT	cytoplasmic protein
Tola_3155	ENOG4105CCY	NADH flavin oxidoreductase, NADH oxidase
Tola_3156	ENOG4105CV1	Transketolase (EC 2.2.1.1)
Tola_3157	ENOG4105CW3	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity)
Tola_3158	ENOG4108YZG	isomerase
Tola_3159	ENOG4105CAX	The 2-keto-3-deoxygluconate permease transports the degraded pectin products into the bacterial cell, where they serve as carbon and energy sources. This is a hydrogen coupled transport system (By similarity)
Tola_3160	ENOG4105G63	Type III effector Hrp-dependent
Tola_3162	ENOG4105CP7	Triose-phosphate isomerase
Tola_3163	ENOG4105DKT	Transcriptional regulator
Tola_3166	ENOG4105C1H	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity)
Tola_3167	ENOG4105DHW	Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins
Tola_3168	ENOG4105VAS	Could be involved in insertion of integral membrane proteins into the membrane (By similarity)
Tola_3169	ENOG4105NVJ	RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity)
Tola_3170	ENOG4105VG0	50S ribosomal protein l34
Tola_3171	ENOG4105CEY	Amp-dependent synthetase and ligase