locus-tag	class	description
Tola_0001	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
Tola_0002	COG0592	DNA-directed DNA polymerase activity
Tola_0004	COG0187	DNA topoisomerase II activity
Tola_0005	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
Tola_0007	COG3977	Valine--pyruvate aminotransferase
Tola_0008	COG0751	glycine-tRNA ligase activity
Tola_0009	COG0752	glycyl-tRNA synthetase alpha subunit
Tola_0010	COG2818	Glycosylase
Tola_0012	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
Tola_0015	COG4208	sulfate ABC transporter
Tola_0016	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
Tola_0017	COG0583	DNA-binding transcription factor activity
Tola_0018	COG0425	Belongs to the sulfur carrier protein TusA family
Tola_0019	COG1653	transport
Tola_0020	COG2205	protein histidine kinase activity
Tola_0021	COG0745	RESPONSE REGULATOR receiver
Tola_0022	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
Tola_0024	COG2801	Transposase and inactivated derivatives
Tola_0027	COG0438	transferase activity, transferring glycosyl groups
Tola_0028	COG0463	Glycosyl transferase, family 2
Tola_0029	COG0859	PFAM glycosyl transferase family 9
Tola_0030	COG0859	PFAM glycosyl transferase family 9
Tola_0031	COG3307	-O-antigen
Tola_0032	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
Tola_0039	COG3833	ABC-type maltose transport systems, permease component
Tola_0042	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
Tola_0043	COG1640	4-alpha-glucanotransferase
Tola_0044	COG0058	SHG alpha-glucan phosphorylase activity
Tola_0045	COG2909	trisaccharide binding
Tola_0046	COG1940	carbohydrate kinase activity
Tola_0047	COG0745	RESPONSE REGULATOR receiver
Tola_0049	COG0191	fructose-bisphosphate aldolase activity
Tola_0051	COG1070	Carbohydrate kinase
Tola_0052	COG1879	ABC-type sugar transport system periplasmic component
Tola_0053	COG1172	Belongs to the binding-protein-dependent transport system permease family
Tola_0054	COG1129	ABC transporter
Tola_0057	COG1376	ErfK ybiS ycfS ynhG family protein
Tola_0058	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
Tola_0059	COG1074	ATP-dependent DNA helicase activity
Tola_0060	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
Tola_0062	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
Tola_0064	COG0513	Belongs to the DEAD box helicase family
Tola_0065	COG0513	Belongs to the DEAD box helicase family
Tola_0066	COG1349	DNA-binding transcription factor activity
Tola_0067	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
Tola_0068	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
Tola_0071	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
Tola_0072	COG3501	Rhs element vgr protein
Tola_0077	COG0523	cobalamin synthesis protein
Tola_0079	COG0589	response to stress
Tola_0081	COG2249	NAD(P)H dehydrogenase (quinone) activity
Tola_0082	COG1770	oligopeptidase
Tola_0084	COG0655	NAD(P)H dehydrogenase (quinone) activity
Tola_0087	COG1842	Phage shock protein A
Tola_0088	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
Tola_0091	COG2095	MarC family integral membrane protein
Tola_0092	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
Tola_0094	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
Tola_0095	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
Tola_0097	COG0165	Argininosuccinate lyase
Tola_0098	COG0051	transcription antitermination factor activity, RNA binding
Tola_0099	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
Tola_0100	COG0088	Forms part of the polypeptide exit tunnel
Tola_0101	COG0089	rRNA binding
Tola_0102	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
Tola_0103	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
Tola_0104	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
Tola_0105	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
Tola_0106	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
Tola_0107	COG0255	Belongs to the universal ribosomal protein uL29 family
Tola_0108	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
Tola_0109	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
Tola_0110	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
Tola_0111	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
Tola_0112	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
Tola_0113	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
Tola_0114	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
Tola_0115	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
Tola_0116	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
Tola_0117	COG1841	ribosomal large subunit assembly
Tola_0118	COG0200	Binds to the 23S rRNA
Tola_0119	COG0201	protein transport
Tola_0120	COG0257	Belongs to the bacterial ribosomal protein bL36 family
Tola_0121	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
Tola_0122	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
Tola_0123	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
Tola_0124	COG0202	RNA polymerase activity
Tola_0125	COG0203	ribosomal protein L17
Tola_0128	COG0626	cystathionine gamma-synthase activity
Tola_0129	COG0460	homoserine dehydrogenase
Tola_0129	COG0527	aspartate kinase activity
Tola_0130	COG1254	Belongs to the acylphosphatase family
Tola_0131	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
Tola_0132	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
Tola_0135	COG3642	lipopolysaccharide core region biosynthetic process
Tola_0136	COG1519	Transferase
Tola_0137	COG0683	leucine binding
Tola_0138	COG0559	Belongs to the binding-protein-dependent transport system permease family
Tola_0142	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
Tola_0144	COG3161	chorismate lyase activity
Tola_0145	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
Tola_0146	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
Tola_0147	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
Tola_0149	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
Tola_0150	COG0569	domain protein
Tola_0151	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
Tola_0151	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
Tola_0152	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
Tola_0153	COG0242	peptide deformylase activity
Tola_0154	COG1652	LysM domain
Tola_0155	COG0758	DNA mediated transformation
Tola_0156	COG2922	Belongs to the Smg family
Tola_0157	COG0551	DNA topoisomerase type I activity
Tola_0158	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
Tola_0159	COG0009	L-threonylcarbamoyladenylate synthase
Tola_0160	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
Tola_0161	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
Tola_0162	COG1262	PFAM Formylglycine-generating sulfatase enzyme
Tola_0164	COG0366	Alpha amylase catalytic
Tola_0165	COG1263	PTS System
Tola_0165	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
Tola_0166	COG1609	Transcriptional regulator
Tola_0167	COG2731	YhcH YjgK YiaL family protein
Tola_0169	COG2873	o-acetylhomoserine
Tola_0170	COG0477	Major facilitator Superfamily
Tola_0171	COG0765	amino acid transport
Tola_0173	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
Tola_0174	COG0646	methionine synthase
Tola_0174	COG1410	methionine synthase
Tola_0175	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
Tola_0177	COG0561	phosphatase activity
Tola_0178	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
Tola_0179	COG1758	RNA polymerase activity
Tola_0181	COG0267	Belongs to the bacterial ribosomal protein bL33 family
Tola_0182	COG0227	Belongs to the bacterial ribosomal protein bL28 family
Tola_0183	COG2003	Belongs to the UPF0758 family
Tola_0184	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
Tola_0185	COG0756	dUTP diphosphatase activity
Tola_0186	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
Tola_0187	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
Tola_0188	COG1561	YicC-like family, N-terminal region
Tola_0189	COG1301	dicarboxylic acid transport
Tola_0190	COG0745	RESPONSE REGULATOR receiver
Tola_0190	COG3706	GGDEF domain
Tola_0191	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
Tola_0192	COG3123	guanosine phosphorylase activity
Tola_0208	COG0515	serine threonine protein kinase
Tola_0208	COG2815	serine threonine protein kinase
Tola_0209	COG3501	Rhs element vgr protein
Tola_0210	COG2918	glutathione biosynthetic process
Tola_0211	COG0625	glutathione transferase activity
Tola_0212	COG3493	citrate carrier protein
Tola_0214	COG3290	protein histidine kinase activity
Tola_0215	COG4565	transcriptional regulatory protein
Tola_0217	COG0351	phosphomethylpyrimidine kinase
Tola_0218	COG0352	thiamine-phosphate diphosphorylase activity
Tola_0219	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
Tola_0221	COG1940	carbohydrate kinase activity
Tola_0221	COG1846	Transcriptional regulator
Tola_0223	COG1063	alcohol dehydrogenase
Tola_0224	COG1028	Short-chain dehydrogenase reductase Sdr
Tola_0225	COG2610	gluconate transmembrane transporter activity
Tola_0226	COG1609	Transcriptional regulator
Tola_0227	COG3265	gluconokinase activity
Tola_0228	COG0129	dihydroxy-acid dehydratase activity
Tola_0229	COG0800	Aldolase
Tola_0231	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
Tola_0232	COG1181	Belongs to the D-alanine--D-alanine ligase family
Tola_0234	COG0697	spore germination
Tola_0235	COG1011	Hydrolase
Tola_0236	COG0583	DNA-binding transcription factor activity
Tola_0237	COG2814	Major facilitator Superfamily
Tola_0238	COG1490	D-aminoacyl-tRNA deacylase activity
Tola_0241	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
Tola_0242	COG3730	PTS system glucitol sorbitol-specific
Tola_0245	COG1028	Short-chain dehydrogenase reductase Sdr
Tola_0247	COG1349	DNA-binding transcription factor activity
Tola_0248	COG1846	Transcriptional regulator
Tola_0249	COG1464	Belongs to the NlpA lipoprotein family
Tola_0250	COG2011	ABC-type metal ion transport system permease component
Tola_0251	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
Tola_0253	COG1077	Cell shape determining protein MreB Mrl
Tola_0254	COG1792	Involved in formation and maintenance of cell shape
Tola_0255	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
Tola_0257	COG1530	ribonuclease E activity
Tola_0258	COG3164	Protein of unknown function
Tola_0259	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
Tola_0260	COG0312	modulator of DNA gyrase
Tola_0261	COG3028	Belongs to the UPF0307 family
Tola_0262	COG0312	modulator of DNA gyrase
Tola_0263	COG2926	Belongs to the UPF0265 family
Tola_0268	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
Tola_0269	COG2166	iron-sulfur cluster assembly
Tola_0271	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
Tola_0272	COG0463	Glycosyl transferase, family 2
Tola_0274	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
Tola_0277	COG3008	intermembrane lipid transfer
Tola_0277	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
Tola_0278	COG2995	paraquat-inducible protein a
Tola_0279	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
Tola_0280	COG0583	DNA-binding transcription factor activity
Tola_0281	COG0166	Belongs to the GPI family
Tola_0282	COG0745	RESPONSE REGULATOR receiver
Tola_0282	COG3706	GGDEF domain
Tola_0283	COG2213	PTS system mannitol-specific
Tola_0283	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
Tola_0284	COG0246	Mannitol dehydrogenase
Tola_0285	COG3722	fumarate hydratase activity
Tola_0286	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
Tola_0286	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
Tola_0286	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
Tola_0287	COG1105	Belongs to the carbohydrate kinase PfkB family
Tola_0288	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
Tola_0288	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
Tola_0289	COG1609	Transcriptional regulator
Tola_0291	COG0534	Mate efflux family protein
Tola_0292	COG1538	Outer membrane efflux protein
Tola_0294	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
Tola_0295	COG0697	spore germination
Tola_0296	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
Tola_0299	COG2771	luxR family
Tola_0300	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
Tola_0301	COG1349	DNA-binding transcription factor activity
Tola_0302	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
Tola_0308	COG1342	Belongs to the UPF0251 family
Tola_0309	COG0257	Belongs to the bacterial ribosomal protein bL36 family
Tola_0310	COG0730	response to heat
Tola_0311	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
Tola_0312	COG0735	belongs to the Fur family
Tola_0315	COG0450	alkyl hydroperoxide reductase
Tola_0325	COG0783	Belongs to the Dps family
Tola_0326	COG0561	phosphatase activity
Tola_0327	COG1968	undecaprenyl-diphosphatase activity
Tola_0331	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
Tola_0332	COG3165	ubiquinone biosynthetic process from chorismate
Tola_0333	COG2226	methyltransferase
Tola_0335	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
Tola_0336	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
Tola_0336	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
Tola_0337	COG0218	Necessary for normal cell division and for the maintenance of normal septation
Tola_0341	COG3501	Rhs element vgr protein
Tola_0344	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
Tola_0347	COG0501	Belongs to the peptidase M48B family
Tola_0348	COG1704	LemA family
Tola_0349	COG0210	DNA helicase
Tola_0350	COG3158	transport of potassium into the cell
Tola_0352	COG1538	Outer membrane efflux protein
Tola_0353	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
Tola_0354	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
Tola_0355	COG1309	transcriptional regulator
Tola_0358	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
Tola_0360	COG3156	type II secretion system protein K
Tola_0361	COG4795	General secretion pathway protein
Tola_0362	COG2165	general secretion pathway protein
Tola_0364	COG2165	general secretion pathway protein
Tola_0365	COG1459	type II secretion system
Tola_0366	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
Tola_0367	COG1450	Type ii and iii secretion system protein
Tola_0370	COG3031	protein transport across the cell outer membrane
Tola_0371	COG0494	nUDIX hydrolase
Tola_0377	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
Tola_0379	COG1166	arginine decarboxylase activity
Tola_0380	COG0471	metal ion transport
Tola_0381	COG0602	queuosine metabolic process
Tola_0382	COG3338	carbonate dehydratase activity
Tola_0383	COG1560	Kdo2-lipid A biosynthetic process
Tola_0384	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
Tola_0384	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
Tola_0385	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
Tola_0386	COG1275	C4-dicarboxylate transporter malic acid transport protein
Tola_0387	COG1538	Outer membrane efflux protein
Tola_0388	COG0842	Transport permease protein
Tola_0389	COG1131	(ABC) transporter
Tola_0390	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
Tola_0392	COG0494	nUDIX hydrolase
Tola_0393	COG3151	Protein conserved in bacteria
Tola_0394	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
Tola_0395	COG3150	esterase
Tola_0396	COG0187	DNA topoisomerase II activity
Tola_0398	COG0659	secondary active sulfate transmembrane transporter activity
Tola_0400	COG3630	sodium ion export across plasma membrane
Tola_0402	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
Tola_0404	COG0697	spore germination
Tola_0406	COG0247	lactate metabolic process
Tola_0407	COG1105	Belongs to the carbohydrate kinase PfkB family
Tola_0411	COG2271	Major facilitator Superfamily
Tola_0413	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
Tola_0414	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
Tola_0415	COG0179	Fumarylacetoacetate (FAA) hydrolase
Tola_0416	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
Tola_0418	COG1328	CTP reductase activity
Tola_0419	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
Tola_0420	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
Tola_0421	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
Tola_0422	COG0625	glutathione transferase activity
Tola_0423	COG2969	positive regulation of protein catabolic process
Tola_0424	COG2823	Periplasmic or secreted lipoprotein
Tola_0425	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
Tola_0426	COG0792	nuclease activity
Tola_0427	COG3107	peptidoglycan biosynthetic process
Tola_0428	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
Tola_0431	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
Tola_0433	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
Tola_0434	COG1169	isochorismate synthase
Tola_0435	COG1575	Belongs to the MenA family. Type 1 subfamily
Tola_0436	COG1280	lysine exporter protein (LysE YggA)
Tola_0437	COG3078	GTPase activator activity
Tola_0439	COG1609	Transcriptional regulator
Tola_0440	COG1349	DNA-binding transcription factor activity
Tola_0441	COG0635	Involved in the biosynthesis of porphyrin-containing compound
Tola_0442	COG1760	l-serine dehydratase
Tola_0443	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
Tola_0443	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
Tola_0443	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
Tola_0444	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
Tola_0446	COG2207	Transcriptional regulator
Tola_0447	COG3133	Outer membrane lipoprotein
Tola_0448	COG1940	carbohydrate kinase activity
Tola_0449	COG1447	Phosphotransferase system cellobiose-specific component IIA
Tola_0450	COG2723	6-phospho-beta-galactosidase activity
Tola_0451	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
Tola_0451	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
Tola_0452	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
Tola_0453	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
Tola_0454	COG1609	Transcriptional regulator
Tola_0456	COG2204	response regulator
Tola_0457	COG3852	Histidine kinase
Tola_0459	COG0174	glutamine synthetase
Tola_0461	COG1295	ribonuclease BN
Tola_0464	COG0204	Acyl-transferase
Tola_0465	COG0586	Pfam SNARE associated Golgi protein
Tola_0466	COG2814	Major facilitator Superfamily
Tola_0469	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
Tola_0470	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
Tola_0471	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
Tola_0474	COG1595	DNA-templated transcription, initiation
Tola_0475	COG3806	Anti-sigma factor
Tola_0477	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
Tola_0480	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
Tola_0481	COG0254	rRNA binding
Tola_0482	COG0281	malic enzyme
Tola_0483	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
Tola_0484	COG1494	fructose-1,6-bisphosphatase
Tola_0487	COG0070	glutamate synthase
Tola_0487	COG0067	glutamate synthase
Tola_0487	COG0069	glutamate synthase activity
Tola_0488	COG0583	DNA-binding transcription factor activity
Tola_0489	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
Tola_0490	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
Tola_0491	COG1611	Belongs to the LOG family
Tola_0493	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
Tola_0493	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
Tola_0498	COG0564	pseudouridine synthase activity
Tola_0500	COG2116	formate transmembrane transporter activity
Tola_0501	COG2146	nitrite reductase [NAD(P)H] activity
Tola_0502	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
Tola_0503	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
Tola_0504	COG1151	hydroxylamine reductase activity
Tola_0505	COG4942	peptidase
Tola_0506	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
Tola_0507	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
Tola_0508	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
Tola_0509	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
Tola_0510	COG0316	Belongs to the HesB IscA family
Tola_0510	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
Tola_0512	COG0004	ammonium transporteR
Tola_0513	COG0596	Alpha beta hydrolase
Tola_0514	COG2183	response to ionizing radiation
Tola_0515	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
Tola_0516	COG2001	Belongs to the MraZ family
Tola_0517	COG0275	rRNA processing
Tola_0518	COG3116	cell division
Tola_0519	COG0768	penicillin binding
Tola_0520	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
Tola_0521	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
Tola_0522	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
Tola_0524	COG0772	Belongs to the SEDS family
Tola_0525	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
Tola_0526	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
Tola_0527	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
Tola_0528	COG0849	cell division
Tola_0529	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
Tola_0530	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
Tola_0532	COG0653	protein targeting
Tola_0533	COG0494	nUDIX hydrolase
Tola_0534	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
Tola_0536	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
Tola_0537	COG1459	type II secretion system
Tola_0538	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
Tola_0540	COG0151	Belongs to the GarS family
Tola_0541	COG0138	bifunctional purine biosynthesis protein purh
Tola_0544	COG2026	Addiction module toxin, RelE StbE family
Tola_0547	COG0488	(ABC) transporter
Tola_0549	COG0795	lipopolysaccharide-transporting ATPase activity
Tola_0550	COG0795	lipopolysaccharide-transporting ATPase activity
Tola_0551	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
Tola_0552	COG2927	DNA polymerase III (CHI subunit)
Tola_0554	COG0583	DNA-binding transcription factor activity
Tola_0555	COG3038	cytochrome b561
Tola_0557	COG2353	YceI-like domain
Tola_0558	COG1741	Belongs to the pirin family
Tola_0559	COG2195	Cleaves the N-terminal amino acid of tripeptides
Tola_0560	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
Tola_0562	COG4948	Mandelate Racemase Muconate Lactonizing
Tola_0564	COG1115	amino acid carrier protein
Tola_0565	COG0450	alkyl hydroperoxide reductase
Tola_0567	COG1278	Cold shock
Tola_0568	COG1418	mRNA catabolic process
Tola_0569	COG1869	D-ribose catabolic process
Tola_0570	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
Tola_0571	COG1869	D-ribose catabolic process
Tola_0573	COG1172	Belongs to the binding-protein-dependent transport system permease family
Tola_0574	COG1879	ABC-type sugar transport system periplasmic component
Tola_0575	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
Tola_0576	COG1609	Transcriptional regulator
Tola_0577	COG1397	ADP-ribosylglycohydrolase
Tola_0579	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
Tola_0580	COG0316	Belongs to the HesB IscA family
Tola_0582	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
Tola_0587	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
Tola_0587	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
Tola_0588	COG2608	mercury ion transmembrane transporter activity
Tola_0589	COG2217	Heavy metal translocating P-type atpase
Tola_0592	COG0842	Transport permease protein
Tola_0593	COG1129	ABC transporter
Tola_0593	COG0842	Transport permease protein
Tola_0594	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
Tola_0597	COG0277	FAD linked oxidase domain protein
Tola_0597	COG0247	lactate metabolic process
Tola_0598	COG2050	protein possibly involved in aromatic compounds catabolism
Tola_0600	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
Tola_0600	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
Tola_0601	COG0259	pyridoxamine-phosphate oxidase activity
Tola_0602	COG1196	nuclear chromosome segregation
Tola_0602	COG3264	Mechanosensitive ion channel
Tola_0603	COG0469	pyruvate kinase activity
Tola_0611	COG0028	Belongs to the TPP enzyme family
Tola_0614	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
Tola_0615	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
Tola_0616	COG1242	4 iron, 4 sulfur cluster binding
Tola_0617	COG2198	Histidine kinase
Tola_0617	COG0784	Response regulator, receiver
Tola_0617	COG5002	protein histidine kinase activity
Tola_0618	COG0232	Belongs to the dGTPase family. Type 2 subfamily
Tola_0620	COG0745	RESPONSE REGULATOR receiver
Tola_0622	COG0083	homoserine kinase activity
Tola_0623	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
Tola_0624	COG2190	(PTS) system
Tola_0625	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
Tola_0626	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
Tola_0627	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
Tola_0628	COG2989	Protein conserved in bacteria
Tola_0630	COG3115	cell septum assembly
Tola_0631	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
Tola_0633	COG0791	NLP P60 protein
Tola_0638	COG0788	formyltetrahydrofolate deformylase activity
Tola_0642	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
Tola_0647	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
Tola_0648	COG0366	Alpha amylase catalytic
Tola_0650	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
Tola_0658	COG3383	formate dehydrogenase (NAD+) activity
Tola_0663	COG2161	toxin-antitoxin pair type II binding
Tola_0667	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
Tola_0668	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
Tola_0669	COG1178	ABC-type Fe3 transport system permease component
Tola_0670	COG4143	(ABC) transporter
Tola_0673	COG4178	(ABC) transporter
Tola_0674	COG4604	ABC transporter, ATP-binding protein
Tola_0675	COG4605	iron ion homeostasis
Tola_0676	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
Tola_0677	COG4607	ABC-type enterochelin transport system periplasmic component
Tola_0679	COG0066	3-isopropylmalate dehydratase activity
Tola_0680	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
Tola_0681	COG0473	3-isopropylmalate dehydrogenase activity
Tola_0682	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
Tola_0683	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
Tola_0684	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
Tola_0687	COG4807	Protein conserved in bacteria
Tola_0688	COG2824	Alkylphosphonate utilization operon protein PhnA
Tola_0689	COG2501	S4 domain
Tola_0690	COG4628	conserved protein (DUF2132)
Tola_0699	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
Tola_0703	COG2801	Transposase and inactivated derivatives
Tola_0711	COG0697	spore germination
Tola_0722	COG0776	regulation of translation
Tola_0736	COG0640	Transcriptional regulator
Tola_0738	COG4373	Mu-like prophage FluMu protein gp28
Tola_0739	COG4383	Mu-like prophage protein gp29
Tola_0743	COG4388	Caudovirus prohead serine protease
Tola_0744	COG4397	Mu-like prophage major head subunit gpT
Tola_0749	COG3941	tape measure
Tola_0759	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
Tola_0761	COG0537	adenosine 5'-monophosphoramidase activity
Tola_0764	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
Tola_0766	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
Tola_0769	COG1286	toxin biosynthetic process
Tola_0770	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
Tola_0773	COG0783	Belongs to the Dps family
Tola_0775	COG1609	Transcriptional regulator
Tola_0776	COG0800	Aldolase
Tola_0778	COG3265	gluconokinase activity
Tola_0779	COG2610	gluconate transmembrane transporter activity
Tola_0781	COG1253	flavin adenine dinucleotide binding
Tola_0786	COG0500	methyltransferase
Tola_0787	COG4106	trans-aconitate 2-methyltransferase activity
Tola_0788	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
Tola_0789	COG0583	DNA-binding transcription factor activity
Tola_0791	COG1643	Atp-dependent helicase
Tola_0792	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
Tola_0794	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
Tola_0795	COG1666	GTP binding
Tola_0796	COG2814	Major facilitator Superfamily
Tola_0799	COG2813	Specifically methylates the guanine in position
Tola_0801	COG0271	Belongs to the BolA IbaG family
Tola_0803	COG4989	oxidoreductase activity
Tola_0804	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
Tola_0805	COG2195	Cleaves the N-terminal amino acid of tripeptides
Tola_0807	COG0737	Belongs to the 5'-nucleotidase family
Tola_0808	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
Tola_0811	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
Tola_0816	COG1131	(ABC) transporter
Tola_0817	COG0842	Transport permease protein
Tola_0818	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
Tola_0819	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
Tola_0820	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
Tola_0821	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
Tola_0822	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
Tola_0823	COG2890	protein-(glutamine-N5) methyltransferase activity
Tola_0824	COG2912	Transglutaminase-like superfamily
Tola_0827	COG0442	prolyl-tRNA aminoacylation
Tola_0828	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
Tola_0830	COG1720	tRNA m6t6A37 methyltransferase activity
Tola_0832	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
Tola_0833	COG4988	ABC transporter
Tola_0836	COG1263	PTS System
Tola_0836	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
Tola_0838	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
Tola_0838	COG1263	PTS System
Tola_0839	COG0354	folic acid binding
Tola_0840	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
Tola_0842	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
Tola_0843	COG1595	DNA-templated transcription, initiation
Tola_0847	COG0481	GTPase activity
Tola_0848	COG0681	Belongs to the peptidase S26 family
Tola_0849	COG0571	ribonuclease III activity
Tola_0851	COG1381	Involved in DNA repair and RecF pathway recombination
Tola_0854	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
Tola_0855	COG0488	(ABC) transporter
Tola_0856	COG1047	Peptidyl-prolyl cis-trans
Tola_0857	COG0735	belongs to the Fur family
Tola_0858	COG0716	FMN binding
Tola_0860	COG0596	Alpha beta hydrolase
Tola_0861	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
Tola_0863	COG4172	Belongs to the ABC transporter superfamily
Tola_0865	COG4171	peptide transport system, permease
Tola_0866	COG4168	peptide transport system, permease
Tola_0868	COG3106	COG3106 Predicted ATPase
Tola_0869	COG3768	UPF0283 membrane protein
Tola_0870	COG2205	protein histidine kinase activity
Tola_0871	COG0745	RESPONSE REGULATOR receiver
Tola_0872	COG2755	lipolytic protein G-D-S-L family
Tola_0873	COG4181	ATPase activity
Tola_0874	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
Tola_0875	COG1090	epimerase
Tola_0877	COG0280	phosphate acetyltransferase
Tola_0877	COG0857	belongs to the CobB CobQ family
Tola_0879	COG3092	negative regulation of chromosome organization
Tola_0880	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
Tola_0881	COG1882	Formate acetyltransferase
Tola_0882	COG2116	formate transmembrane transporter activity
Tola_0883	COG1944	ATP diphosphatase activity
Tola_0884	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
Tola_0885	COG0820	rRNA (adenine-C2-)-methyltransferase activity
Tola_0887	COG1426	Protein conserved in bacteria
Tola_0889	COG0124	histidyl-tRNA synthetase
Tola_0890	COG2976	Protein conserved in bacteria
Tola_0891	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
Tola_0892	COG1160	GTP binding
Tola_0895	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
Tola_0900	COG4215	(ABC) transporter
Tola_0901	COG4160	amino acid transport
Tola_0903	COG0708	Exodeoxyribonuclease III
Tola_0904	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
Tola_0907	COG0300	oxidoreductase activity
Tola_0908	COG0741	lytic transglycosylase activity
Tola_0908	COG1388	LysM domain
Tola_0909	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
Tola_0910	COG2226	methyltransferase
Tola_0911	COG0328	RNA-DNA hybrid ribonuclease activity
Tola_0912	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
Tola_0913	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
Tola_0914	COG0121	glutamine amidotransferase
Tola_0915	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
Tola_0916	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
Tola_0917	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
Tola_0919	COG4783	chaperone-mediated protein folding
Tola_0920	COG0628	permease
Tola_0921	COG3118	belongs to the thioredoxin family
Tola_0922	COG2091	lysine biosynthetic process via aminoadipic acid
Tola_0923	COG3083	sulfuric ester hydrolase activity
Tola_0925	COG3081	Nucleoid-associated protein
Tola_0926	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
Tola_0929	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
Tola_0930	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
Tola_0933	COG2204	response regulator
Tola_0934	COG1210	Utp--glucose-1-phosphate uridylyltransferase
Tola_0935	COG1555	photosystem II stabilization
Tola_0936	COG1218	3'(2'),5'-bisphosphate nucleotidase
Tola_0937	COG2350	Protein conserved in bacteria
Tola_0938	COG2917	probably involved in intracellular septation
Tola_0939	COG0159	tryptophan synthase activity
Tola_0940	COG0133	tryptophan synthase activity
Tola_0941	COG0135	phosphoribosylanthranilate isomerase activity
Tola_0941	COG0134	indole-3-glycerol-phosphate synthase activity
Tola_0942	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
Tola_0943	COG0512	Glutamine amidotransferase of anthranilate synthase
Tola_0943	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
Tola_0944	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
Tola_0946	COG0009	L-threonylcarbamoyladenylate synthase
Tola_0948	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
Tola_0949	COG1956	GAF domain-containing protein
Tola_0953	COG1988	membrane-bound metal-dependent
Tola_0956	COG2204	response regulator
Tola_0957	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
Tola_0958	COG1194	a g-specific adenine glycosylase
Tola_0959	COG0220	tRNA (guanine-N7-)-methyltransferase activity
Tola_0960	COG0635	Involved in the biosynthesis of porphyrin-containing compound
Tola_0961	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
Tola_0962	COG1872	DUF167
Tola_0963	COG0762	integral membrane protein
Tola_0964	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
Tola_0965	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
Tola_0968	COG3022	response to hydroperoxide
Tola_0969	COG0513	Belongs to the DEAD box helicase family
Tola_0970	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
Tola_0971	COG0716	FMN binding
Tola_0972	COG4974	Belongs to the 'phage' integrase family
Tola_0974	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
Tola_0976	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
Tola_0977	COG0488	(ABC) transporter
Tola_0978	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
Tola_0980	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
Tola_0986	COG2723	6-phospho-beta-galactosidase activity
Tola_0987	COG0583	DNA-binding transcription factor activity
Tola_0988	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
Tola_0990	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
Tola_0991	COG4136	ATPase activity
Tola_0992	COG4135	transport system, permease component
Tola_0993	COG4134	Bacterial extracellular solute-binding protein
Tola_0994	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
Tola_0995	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
Tola_0996	COG0604	alcohol dehydrogenase
Tola_0997	COG1309	transcriptional regulator
Tola_0999	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
Tola_0999	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
Tola_1001	COG0671	phosphoesterase, PA-phosphatase related
Tola_1005	COG0701	Predicted permease
Tola_1007	COG0798	PFAM Bile acid sodium symporter
Tola_1008	COG2832	Protein of unknown function (DUF454)
Tola_1011	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
Tola_1014	COG0395	ABC-type sugar transport system, permease component
Tola_1015	COG1621	beta-fructofuranosidase activity
Tola_1017	COG1609	Transcriptional regulator
Tola_1019	COG0469	pyruvate kinase activity
Tola_1020	COG1737	Transcriptional regulator
Tola_1021	COG0837	glucose binding
Tola_1023	COG0501	Belongs to the peptidase M48B family
Tola_1024	COG0545	Peptidyl-prolyl cis-trans isomerase
Tola_1025	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
Tola_1026	COG0505	Belongs to the CarA family
Tola_1027	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
Tola_1028	COG5006	permease, DMT superfamily
Tola_1031	COG1538	Outer membrane efflux protein
Tola_1032	COG1566	PFAM secretion protein HlyD family protein
Tola_1033	COG2814	Major facilitator Superfamily
Tola_1034	COG0235	Class ii aldolase
Tola_1036	COG1263	PTS System
Tola_1036	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
Tola_1040	COG3254	rhamnose metabolic process
Tola_1042	COG4806	L-rhamnose isomerase
Tola_1043	COG1070	Carbohydrate kinase
Tola_1045	COG1454	alcohol dehydrogenase
Tola_1047	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
Tola_1048	COG2719	SpoVR family
Tola_1049	COG2718	Belongs to the UPF0229 family
Tola_1050	COG2766	serine protein kinase
Tola_1052	COG0058	SHG alpha-glucan phosphorylase activity
Tola_1053	COG0307	riboflavin synthase, alpha
Tola_1054	COG0513	Belongs to the DEAD box helicase family
Tola_1060	COG2801	Transposase and inactivated derivatives
Tola_1065	COG1011	Hydrolase
Tola_1068	COG3040	lipid binding
Tola_1071	COG1199	ATP-dependent helicase activity
Tola_1073	COG3065	identical protein binding
Tola_1074	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
Tola_1076	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
Tola_1080	COG1366	Belongs to the anti-sigma-factor antagonist family
Tola_1081	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
Tola_1082	COG0544	peptidyl-prolyl cis-trans isomerase activity
Tola_1083	COG0740	serine-type endopeptidase activity
Tola_1084	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
Tola_1085	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
Tola_1086	COG0776	regulation of translation
Tola_1087	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
Tola_1088	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
Tola_1089	COG0793	Belongs to the peptidase S41A family
Tola_1090	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
Tola_1091	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
Tola_1092	COG0017	Asparaginyl-tRNA synthetase
Tola_1094	COG1486	melibiose metabolic process
Tola_1095	COG0583	DNA-binding transcription factor activity
Tola_1097	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
Tola_1098	COG0156	8-amino-7-oxononanoate synthase activity
Tola_1100	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
Tola_1101	COG0501	Belongs to the peptidase M48B family
Tola_1102	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
Tola_1103	COG0729	surface antigen
Tola_1107	COG1012	belongs to the aldehyde dehydrogenase family
Tola_1109	COG1177	transmembrane transport
Tola_1110	COG1176	ABC-type spermidine putrescine transport system, permease component I
Tola_1112	COG3842	ATPase activity
Tola_1113	COG3272	Protein of unknown function (DUF1722)
Tola_1114	COG0415	Belongs to the DNA photolyase family
Tola_1115	COG0556	nucleotide-excision repair
Tola_1116	COG0302	gtp cyclohydrolase
Tola_1117	COG2925	Exonuclease
Tola_1119	COG2391	methyltransferase activity
Tola_1120	COG3013	Belongs to the UPF0304 family
Tola_1122	COG0463	Glycosyl transferase, family 2
Tola_1125	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
Tola_1126	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
Tola_1129	COG1876	peptidase activity
Tola_1130	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
Tola_1131	COG1393	Belongs to the ArsC family
Tola_1137	COG1979	alcohol dehydrogenase
Tola_1142	COG2003	Belongs to the UPF0758 family
Tola_1156	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
Tola_1157	COG0732	type I restriction modification DNA specificity domain
Tola_1166	COG1160	GTP binding
Tola_1167	COG0218	Necessary for normal cell division and for the maintenance of normal septation
Tola_1170	COG4983	Phage plasmid primase, P4 family domain protein
Tola_1173	COG0582	viral genome integration into host DNA
Tola_1174	COG1414	Transcriptional regulator
Tola_1175	COG4948	Mandelate Racemase Muconate Lactonizing
Tola_1176	COG2271	Major facilitator Superfamily
Tola_1178	COG1454	alcohol dehydrogenase
Tola_1181	COG4804	nuclease activity
Tola_1185	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
Tola_1187	COG0210	DNA helicase
Tola_1191	COG3706	GGDEF domain
Tola_1192	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
Tola_1193	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
Tola_1194	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
Tola_1195	COG2205	protein histidine kinase activity
Tola_1196	COG0745	RESPONSE REGULATOR receiver
Tola_1203	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
Tola_1204	COG1342	Belongs to the UPF0251 family
Tola_1205	COG0735	belongs to the Fur family
Tola_1210	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
Tola_1214	COG0861	Integral membrane protein TerC family
Tola_1217	COG2920	part of a sulfur-relay system
Tola_1218	COG1289	transmembrane transporter activity
Tola_1220	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
Tola_1221	COG0732	type I restriction modification DNA specificity domain
Tola_1223	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
Tola_1227	COG0564	pseudouridine synthase activity
Tola_1228	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
Tola_1229	COG4597	amino acid ABC transporter
Tola_1230	COG0765	amino acid transport
Tola_1231	COG1126	abc transporter atp-binding protein
Tola_1232	COG0366	Alpha amylase catalytic
Tola_1233	COG0366	Alpha amylase catalytic
Tola_1234	COG3842	ATPase activity
Tola_1237	COG1653	transport
Tola_1238	COG0583	DNA-binding transcription factor activity
Tola_1239	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
Tola_1239	COG1263	PTS System
Tola_1241	COG1028	Short-chain dehydrogenase reductase Sdr
Tola_1245	COG4591	ABC-type transport system involved in lipoprotein release permease component
Tola_1246	COG0577	efflux transmembrane transporter activity
Tola_1246	COG1136	(ABC) transporter
Tola_1247	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
Tola_1248	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
Tola_1249	COG1678	Uncharacterized ACR, COG1678
Tola_1250	COG0189	ligase activity
Tola_1251	COG1385	rRNA (uridine-N3-)-methyltransferase activity
Tola_1254	COG3091	SprT-like family
Tola_1255	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
Tola_1256	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
Tola_1257	COG0126	phosphoglycerate kinase activity
Tola_1258	COG0191	fructose-bisphosphate aldolase activity
Tola_1259	COG1132	(ABC) transporter
Tola_1260	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
Tola_1268	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
Tola_1271	COG0306	phosphate transporter
Tola_1273	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
Tola_1274	COG1368	sulfuric ester hydrolase activity
Tola_1276	COG1643	Atp-dependent helicase
Tola_1278	COG1278	Cold shock
Tola_1279	COG1132	(ABC) transporter
Tola_1280	COG1132	(ABC) transporter
Tola_1281	COG3770	Murein endopeptidase that cleaves the D-alanyl-meso-2,6- diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus
Tola_1283	COG1970	mechanosensitive ion channel activity
Tola_1286	COG0469	pyruvate kinase activity
Tola_1288	COG1253	flavin adenine dinucleotide binding
Tola_1296	COG1280	lysine exporter protein (LysE YggA)
Tola_1298	COG1280	lysine exporter protein (LysE YggA)
Tola_1300	COG0564	pseudouridine synthase activity
Tola_1303	COG0697	spore germination
Tola_1307	COG2897	thiosulfate sulfurtransferase activity
Tola_1313	COG2996	Protein conserved in bacteria
Tola_1315	COG4681	YaeQ
Tola_1316	COG0673	inositol 2-dehydrogenase activity
Tola_1318	COG0574	Belongs to the PEP-utilizing enzyme family
Tola_1318	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
Tola_1320	COG1017	nitric oxide dioxygenase activity
Tola_1320	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
Tola_1322	COG1322	Protein conserved in bacteria
Tola_1327	COG2272	Belongs to the type-B carboxylesterase lipase family
Tola_1328	COG2272	Belongs to the type-B carboxylesterase lipase family
Tola_1329	COG0667	Aldo Keto reductase
Tola_1333	COG0656	L-ascorbic acid biosynthetic process
Tola_1337	COG0395	ABC-type sugar transport system, permease component
Tola_1342	COG0531	amino acid
Tola_1345	COG4702	Belongs to the UPF0303 family
Tola_1347	COG3706	GGDEF domain
Tola_1348	COG0628	permease
Tola_1351	COG1127	ABC transporter
Tola_1352	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
Tola_1353	COG1136	(ABC) transporter
Tola_1355	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
Tola_1358	COG1518	maintenance of DNA repeat elements
Tola_1359	COG1203	CRISPR-associated helicase, Cas3
Tola_1365	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
Tola_1366	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
Tola_1368	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
Tola_1369	COG1966	Carbon starvation protein
Tola_1370	COG3279	Response regulator of the LytR AlgR family
Tola_1371	COG3275	phosphorelay sensor kinase activity
Tola_1376	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
Tola_1377	COG1605	Chorismate mutase
Tola_1377	COG0287	Prephenate dehydrogenase
Tola_1379	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
Tola_1381	COG0583	DNA-binding transcription factor activity
Tola_1382	COG0616	signal peptide processing
Tola_1383	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
Tola_1385	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
Tola_1386	COG2204	response regulator
Tola_1389	COG0513	Belongs to the DEAD box helicase family
Tola_1390	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
Tola_1391	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
Tola_1392	COG0534	Mate efflux family protein
Tola_1397	COG1187	pseudouridine synthase activity
Tola_1398	COG1739	Uncharacterized protein family UPF0029
Tola_1407	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
Tola_1411	COG3420	alginic acid biosynthetic process
Tola_1414	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
Tola_1414	COG0662	Cupin 2, conserved barrel domain protein
Tola_1418	COG0116	Belongs to the methyltransferase superfamily
Tola_1418	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
Tola_1421	COG3130	regulation of translation
Tola_1422	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
Tola_1423	COG1067	ATP-dependent peptidase activity
Tola_1429	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
Tola_1434	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
Tola_1435	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
Tola_1438	COG0583	DNA-binding transcription factor activity
Tola_1439	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
Tola_1440	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
Tola_1442	COG0346	lactoylglutathione lyase activity
Tola_1443	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
Tola_1445	COG4659	FMN binding
Tola_1446	COG4658	electron transport chain
Tola_1447	COG4656	Part of a membrane complex involved in electron transport
Tola_1448	COG2878	Part of a membrane complex involved in electron transport
Tola_1449	COG4657	Part of a membrane complex involved in electron transport
Tola_1452	COG1451	nucleotide metabolic process
Tola_1453	COG4628	conserved protein (DUF2132)
Tola_1454	COG0730	response to heat
Tola_1456	COG3593	DNA synthesis involved in DNA repair
Tola_1457	COG0205	6-phosphofructokinase activity
Tola_1459	COG1434	Gram-negative-bacterium-type cell wall biogenesis
Tola_1460	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
Tola_1462	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
Tola_1465	COG5433	transposase activity
Tola_1467	COG1448	Aminotransferase
Tola_1472	COG0210	DNA helicase
Tola_1473	COG2223	nitrite transmembrane transporter activity
Tola_1474	COG2862	Uncharacterized protein family, UPF0114
Tola_1476	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
Tola_1479	COG1994	Peptidase M50
Tola_1482	COG2723	6-phospho-beta-galactosidase activity
Tola_1484	COG0137	argininosuccinate synthase activity
Tola_1485	COG1120	ATPase activity
Tola_1486	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
Tola_1489	COG4615	Cyclic peptide transporter
Tola_1491	COG0583	DNA-binding transcription factor activity
Tola_1492	COG1979	alcohol dehydrogenase
Tola_1493	COG0589	response to stress
Tola_1494	COG0659	secondary active sulfate transmembrane transporter activity
Tola_1495	COG1902	pentaerythritol trinitrate reductase activity
Tola_1496	COG0583	DNA-binding transcription factor activity
Tola_1497	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
Tola_1500	COG2272	Belongs to the type-B carboxylesterase lipase family
Tola_1502	COG0667	Aldo Keto reductase
Tola_1507	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
Tola_1513	COG0579	oxidoreductase
Tola_1516	COG2951	lytic endotransglycosylase activity
Tola_1519	COG0667	Aldo Keto reductase
Tola_1522	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
Tola_1524	COG1448	Aminotransferase
Tola_1525	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
Tola_1527	COG1349	DNA-binding transcription factor activity
Tola_1528	COG0717	Belongs to the dCTP deaminase family
Tola_1529	COG0572	uridine kinase
Tola_1530	COG0489	protein tyrosine kinase activity
Tola_1531	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
Tola_1531	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
Tola_1533	COG2850	peptidyl-arginine hydroxylation
Tola_1535	COG0531	amino acid
Tola_1536	COG4303	Ethanolamine ammonia lyase large subunit
Tola_1538	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
Tola_1539	COG1584	GPR1 FUN34 yaaH family protein
Tola_1540	COG1252	NADH dehydrogenase
Tola_1541	COG3150	esterase
Tola_1542	COG1472	Belongs to the glycosyl hydrolase 3 family
Tola_1543	COG0077	Prephenate dehydratase
Tola_1543	COG1605	Chorismate mutase
Tola_1545	COG0167	dihydroorotate dehydrogenase activity
Tola_1546	COG0308	aminopeptidase N
Tola_1547	COG2197	response regulator
Tola_1548	COG0322	excinuclease ABC activity
Tola_1551	COG2916	Histone family protein nucleoid-structuring protein H-NS
Tola_1553	COG0284	orotidine-5'-phosphate decarboxylase activity
Tola_1554	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
Tola_1556	COG0776	regulation of translation
Tola_1557	COG0539	negative regulation of cytoplasmic translation
Tola_1558	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
Tola_1559	COG2983	Belongs to the UPF0260 family
Tola_1560	COG3100	YcgL domain-containing protein
Tola_1561	COG0850	regulation of cytokinetic process
Tola_1562	COG2894	cell division
Tola_1563	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
Tola_1564	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
Tola_1565	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
Tola_1566	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
Tola_1567	COG0285	dihydrofolate synthase activity
Tola_1568	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
Tola_1569	COG0101	tRNA pseudouridine synthase activity
Tola_1571	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
Tola_1572	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
Tola_1574	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
Tola_1574	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
Tola_1575	COG0598	Magnesium transport protein CorA
Tola_1577	COG0114	fumarate hydratase activity
Tola_1578	COG4598	ABC transporter
Tola_1579	COG4160	amino acid transport
Tola_1580	COG4215	(ABC) transporter
Tola_1582	COG1051	belongs to the nudix hydrolase family
Tola_1583	COG3036	rescue of stalled ribosome
Tola_1589	COG0556	nucleotide-excision repair
Tola_1590	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
Tola_1592	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
Tola_1606	COG4584	PFAM Integrase catalytic
Tola_1607	COG1484	DNA-dependent DNA replication
Tola_1609	COG0210	DNA helicase
Tola_1610	COG1196	nuclear chromosome segregation
Tola_1615	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
Tola_1616	COG0830	nickel cation binding
Tola_1618	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
Tola_1619	COG0804	urea catabolic process
Tola_1620	COG0832	Belongs to the urease beta subunit family
Tola_1621	COG0831	urea catabolic process
Tola_1622	COG0829	nickel cation binding
Tola_1623	COG0410	ABC transporter
Tola_1624	COG0411	ABC transporter
Tola_1626	COG0559	Belongs to the binding-protein-dependent transport system permease family
Tola_1628	COG2198	Histidine kinase
Tola_1628	COG5002	protein histidine kinase activity
Tola_1628	COG0784	Response regulator, receiver
Tola_1629	COG0745	RESPONSE REGULATOR receiver
Tola_1630	COG1522	sequence-specific DNA binding
Tola_1632	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
Tola_1633	COG4215	(ABC) transporter
Tola_1637	COG0589	response to stress
Tola_1642	COG0435	Glutathione S-transferase
Tola_1647	COG1942	4-Oxalocrotonate Tautomerase
Tola_1649	COG2272	Belongs to the type-B carboxylesterase lipase family
Tola_1652	COG1349	DNA-binding transcription factor activity
Tola_1654	COG1522	sequence-specific DNA binding
Tola_1655	COG1280	lysine exporter protein (LysE YggA)
Tola_1657	COG0157	Belongs to the NadC ModD family
Tola_1661	COG1342	Belongs to the UPF0251 family
Tola_1662	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
Tola_1665	COG1492	cobalamin metabolic process
Tola_1675	COG2875	Belongs to the precorrin methyltransferase family
Tola_1677	COG2241	protein methyltransferase activity
Tola_1678	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
Tola_1684	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
Tola_1691	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
Tola_1692	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
Tola_1693	COG4869	propanediol catabolic process
Tola_1695	COG4576	ethanolamine utilization protein EutN carboxysome structural protein Ccml
Tola_1699	COG4656	Part of a membrane complex involved in electron transport
Tola_1701	COG4810	utilization protein
Tola_1703	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
Tola_1704	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
Tola_1704	COG1648	precorrin-2 dehydrogenase activity
Tola_1707	COG3940	Belongs to the glycosyl hydrolase 43 family
Tola_1708	COG1609	Transcriptional regulator
Tola_1710	COG0395	ABC-type sugar transport system, permease component
Tola_1712	COG3842	ATPase activity
Tola_1717	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
Tola_1718	COG0714	Associated with various cellular activities
Tola_1724	COG0776	regulation of translation
Tola_1725	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
Tola_1725	COG0072	phenylalanine-tRNA ligase activity
Tola_1726	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
Tola_1727	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
Tola_1728	COG0291	Belongs to the bacterial ribosomal protein bL35 family
Tola_1730	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
Tola_1731	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
Tola_1732	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
Tola_1733	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
Tola_1735	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
Tola_1736	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
Tola_1737	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
Tola_1738	COG0131	Imidazoleglycerol-phosphate dehydratase
Tola_1738	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
Tola_1739	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
Tola_1740	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
Tola_1741	COG0107	imidazoleglycerol-phosphate synthase activity
Tola_1743	COG0745	RESPONSE REGULATOR receiver
Tola_1743	COG3706	GGDEF domain
Tola_1744	COG1846	Transcriptional regulator
Tola_1746	COG1566	PFAM secretion protein HlyD family protein
Tola_1747	COG2814	Major facilitator Superfamily
Tola_1750	COG0039	L-malate dehydrogenase activity
Tola_1755	COG0314	molybdopterin synthase activity
Tola_1756	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
Tola_1757	COG0315	cyclic pyranopterin monophosphate synthase activity
Tola_1758	COG0521	Mo-molybdopterin cofactor biosynthetic process
Tola_1759	COG0746	molybdenum cofactor guanylyltransferase activity
Tola_1760	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
Tola_1764	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
Tola_1764	COG2146	nitrite reductase [NAD(P)H] activity
Tola_1766	COG2223	nitrite transmembrane transporter activity
Tola_1767	COG0583	DNA-binding transcription factor activity
Tola_1769	COG1902	pentaerythritol trinitrate reductase activity
Tola_1769	COG0446	pyridine nucleotide-disulphide oxidoreductase
Tola_1770	COG1116	anion transmembrane transporter activity
Tola_1771	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
Tola_1772	COG1116	anion transmembrane transporter activity
Tola_1772	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
Tola_1774	COG1648	precorrin-2 dehydrogenase activity
Tola_1774	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
Tola_1775	COG0243	molybdopterin cofactor binding
Tola_1776	COG1573	uracil-dna glycosylase
Tola_1779	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
Tola_1780	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
Tola_1782	COG2814	Major facilitator Superfamily
Tola_1784	COG1349	DNA-binding transcription factor activity
Tola_1786	COG0667	Aldo Keto reductase
Tola_1789	COG0583	DNA-binding transcription factor activity
Tola_1790	COG1979	alcohol dehydrogenase
Tola_1792	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
Tola_1794	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
Tola_1795	COG0129	dihydroxy-acid dehydratase activity
Tola_1796	COG0800	Aldolase
Tola_1799	COG1609	Transcriptional regulator
Tola_1805	COG3180	Ammonia monooxygenase
Tola_1806	COG0443	Heat shock 70 kDa protein
Tola_1808	COG1028	Short-chain dehydrogenase reductase Sdr
Tola_1815	COG0778	Nitroreductase
Tola_1818	COG4737	Cytotoxic translational repressor of toxin-antitoxin stability system
Tola_1819	COG2944	sequence-specific DNA binding
Tola_1820	COG1238	metal cluster binding
Tola_1826	COG2226	methyltransferase
Tola_1829	COG1869	D-ribose catabolic process
Tola_1831	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
Tola_1832	COG3958	Transketolase
Tola_1833	COG3959	Transketolase, thiamine diphosphate binding domain
Tola_1834	COG1172	Belongs to the binding-protein-dependent transport system permease family
Tola_1835	COG1129	ABC transporter
Tola_1838	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
Tola_1840	COG3604	Transcriptional regulator
Tola_1841	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
Tola_1842	COG1017	nitric oxide dioxygenase activity
Tola_1842	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
Tola_1843	COG0745	RESPONSE REGULATOR receiver
Tola_1843	COG3706	GGDEF domain
Tola_1844	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
Tola_1846	COG0583	DNA-binding transcription factor activity
Tola_1847	COG0439	Biotin carboxylase
Tola_1848	COG0511	ligase activity, forming carbon-carbon bonds
Tola_1848	COG5016	pyruvate
Tola_1849	COG2194	sulfuric ester hydrolase activity
Tola_1853	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
Tola_1857	COG1914	H( )-stimulated, divalent metal cation uptake system
Tola_1858	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
Tola_1859	COG1984	allophanate hydrolase subunit 2
Tola_1860	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
Tola_1863	COG1126	abc transporter atp-binding protein
Tola_1870	COG3550	peptidyl-serine autophosphorylation
Tola_1873	COG1349	DNA-binding transcription factor activity
Tola_1875	COG1028	Short-chain dehydrogenase reductase Sdr
Tola_1878	COG3730	PTS system glucitol sorbitol-specific
Tola_1887	COG0517	IMP dehydrogenase activity
Tola_1887	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
Tola_1888	COG0673	inositol 2-dehydrogenase activity
Tola_1889	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
Tola_1890	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
Tola_1891	COG0574	Belongs to the PEP-utilizing enzyme family
Tola_1891	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
Tola_1892	COG0371	Dehydrogenase
Tola_1893	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
Tola_1895	COG2207	Transcriptional regulator
Tola_1896	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
Tola_1897	COG2207	Transcriptional regulator
Tola_1898	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
Tola_1899	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
Tola_1899	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
Tola_1899	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
Tola_1901	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
Tola_1903	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
Tola_1904	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
Tola_1905	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
Tola_1907	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
Tola_1907	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
Tola_1907	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
Tola_1915	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
Tola_1916	COG0642	Histidine kinase
Tola_1917	COG0745	RESPONSE REGULATOR receiver
Tola_1918	COG0215	cysteine-tRNA ligase activity
Tola_1919	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
Tola_1920	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
Tola_1924	COG2815	serine threonine protein kinase
Tola_1924	COG0515	serine threonine protein kinase
Tola_1928	COG1979	alcohol dehydrogenase
Tola_1932	COG2207	Transcriptional regulator
Tola_1936	COG3550	peptidyl-serine autophosphorylation
Tola_1940	COG1737	Transcriptional regulator
Tola_1941	COG1172	Belongs to the binding-protein-dependent transport system permease family
Tola_1946	COG2211	Major facilitator Superfamily
Tola_1949	COG1028	Short-chain dehydrogenase reductase Sdr
Tola_1951	COG0318	PFAM AMP-dependent synthetase and ligase
Tola_1953	COG3300	MHYT domain
Tola_1953	COG5001	Diguanylate cyclase
Tola_1955	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
Tola_1960	COG2186	Transcriptional regulator
Tola_1961	COG3842	ATPase activity
Tola_1963	COG1176	ABC-type spermidine putrescine transport system, permease component I
Tola_1964	COG0573	inorganic phosphate transmembrane transporter activity
Tola_1968	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
Tola_1969	COG0805	protein transport
Tola_1970	COG1940	carbohydrate kinase activity
Tola_1971	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
Tola_1972	COG1172	Belongs to the binding-protein-dependent transport system permease family
Tola_1973	COG1129	ABC transporter
Tola_1974	COG1879	ABC-type sugar transport system periplasmic component
Tola_1975	COG1737	Transcriptional regulator
Tola_1976	COG2190	(PTS) system
Tola_1976	COG1263	PTS System
Tola_1976	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
Tola_1978	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
Tola_1979	COG0698	ribose 5-phosphate isomerase
Tola_1982	COG0765	amino acid transport
Tola_1983	COG0765	amino acid transport
Tola_1991	COG0667	Aldo Keto reductase
Tola_1993	COG2814	Major facilitator Superfamily
Tola_1995	COG0493	'glutamate synthase
Tola_1996	COG1013	pyruvate-flavodoxin oxidoreductase activity
Tola_1996	COG0674	pyruvate-flavodoxin oxidoreductase activity
Tola_1996	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
Tola_1996	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
Tola_2001	COG0667	Aldo Keto reductase
Tola_2002	COG1733	regulation of RNA biosynthetic process
Tola_2003	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
Tola_2004	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
Tola_2005	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
Tola_2007	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
Tola_2008	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
Tola_2009	COG0583	DNA-binding transcription factor activity
Tola_2011	COG2853	Lipoprotein
Tola_2012	COG0105	UTP biosynthetic process
Tola_2013	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
Tola_2015	COG0443	Heat shock 70 kDa protein
Tola_2019	COG1104	cysteine desulfurase activity
Tola_2020	COG1959	2 iron, 2 sulfur cluster binding
Tola_2026	COG2897	thiosulfate sulfurtransferase activity
Tola_2027	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
Tola_2028	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
Tola_2029	COG1862	Preprotein translocase
Tola_2030	COG0343	queuine tRNA-ribosyltransferase activity
Tola_2031	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
Tola_2033	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
Tola_2034	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
Tola_2039	COG1088	dTDP-glucose 4,6-dehydratase activity
Tola_2046	COG3754	Rhamnan synthesis protein F
Tola_2049	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
Tola_2052	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
Tola_2053	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
Tola_2055	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
Tola_2056	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
Tola_2059	COG0704	Plays a role in the regulation of phosphate uptake
Tola_2060	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
Tola_2061	COG0581	inorganic phosphate transmembrane transporter activity
Tola_2062	COG0573	inorganic phosphate transmembrane transporter activity
Tola_2063	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
Tola_2064	COG0248	Ppx GppA phosphatase
Tola_2065	COG0590	tRNA wobble adenosine to inosine editing
Tola_2067	COG5002	protein histidine kinase activity
Tola_2070	COG0420	3'-5' exonuclease activity
Tola_2072	COG2974	May be involved in recombination
Tola_2074	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
Tola_2075	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
Tola_2076	COG0483	inositol monophosphate 1-phosphatase activity
Tola_2077	COG3135	benzoate transporter
Tola_2078	COG1396	sequence-specific DNA binding
Tola_2079	COG3300	MHYT domain
Tola_2079	COG5001	Diguanylate cyclase
Tola_2080	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
Tola_2081	COG2814	Major facilitator Superfamily
Tola_2082	COG0109	protoheme IX farnesyltransferase activity
Tola_2083	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
Tola_2084	COG1845	cytochrome c oxidase, subunit III
Tola_2085	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
Tola_2086	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
Tola_2088	COG1253	flavin adenine dinucleotide binding
Tola_2089	COG2119	membrane
Tola_2091	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
Tola_2091	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
Tola_2091	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
Tola_2093	COG1355	regulation of microtubule-based process
Tola_2094	COG2078	PFAM AMMECR1 domain protein
Tola_2094	COG3885	ferrous iron binding
Tola_2095	COG0825	malonyl-CoA metabolic process
Tola_2098	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
Tola_2099	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
Tola_2100	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
Tola_2101	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
Tola_2104	COG0750	zinc metalloprotease
Tola_2105	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
Tola_2106	COG0575	Belongs to the CDS family
Tola_2107	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
Tola_2108	COG0233	cytoplasmic translational termination
Tola_2109	COG0528	UMP kinase activity
Tola_2110	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
Tola_2111	COG0052	Belongs to the universal ribosomal protein uS2 family
Tola_2113	COG0024	Methionine aminopeptidase
Tola_2114	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
Tola_2115	COG2171	N-acyltransferase activity
Tola_2118	COG0747	negative chemotaxis
Tola_2119	COG0601	transmembrane transport
Tola_2120	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
Tola_2121	COG4172	Belongs to the ABC transporter superfamily
Tola_2122	COG0667	Aldo Keto reductase
Tola_2123	COG2169	Transcriptional regulator
Tola_2124	COG1486	melibiose metabolic process
Tola_2128	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
Tola_2129	COG1546	Belongs to the CinA family
Tola_2129	COG1058	Belongs to the CinA family
Tola_2132	COG0545	Peptidyl-prolyl cis-trans isomerase
Tola_2133	COG2900	Belongs to the SlyX family
Tola_2134	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
Tola_2135	COG1263	PTS System
Tola_2135	COG2190	(PTS) system
Tola_2135	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
Tola_2136	COG0363	glucosamine-6-phosphate deaminase activity
Tola_2137	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
Tola_2138	COG1940	carbohydrate kinase activity
Tola_2138	COG1846	Transcriptional regulator
Tola_2140	COG0583	DNA-binding transcription factor activity
Tola_2141	COG1609	Transcriptional regulator
Tola_2142	COG1621	beta-fructofuranosidase activity
Tola_2143	COG0622	Phosphoesterase
Tola_2145	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
Tola_2147	COG0417	DNA replication proofreading
Tola_2149	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
Tola_2150	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
Tola_2150	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
Tola_2151	COG0527	aspartate kinase activity
Tola_2153	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
Tola_2156	COG1172	Belongs to the binding-protein-dependent transport system permease family
Tola_2157	COG1129	ABC transporter
Tola_2158	COG1879	ABC-type sugar transport system periplasmic component
Tola_2160	COG1069	ribulokinase activity
Tola_2162	COG2160	L-arabinose isomerase activity
Tola_2163	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
Tola_2165	COG0569	domain protein
Tola_2165	COG2985	domain, Protein
Tola_2167	COG3313	Fe-S protein
Tola_2169	COG2814	Major facilitator Superfamily
Tola_2171	COG0519	Catalyzes the synthesis of GMP from XMP
Tola_2171	COG0518	GMP synthase (glutamine-hydrolyzing) activity
Tola_2172	COG0517	IMP dehydrogenase activity
Tola_2172	COG0516	GMP reductase activity
Tola_2173	COG1570	exodeoxyribonuclease VII activity
Tola_2174	COG1607	acyl-coa hydrolase
Tola_2175	COG2095	MarC family integral membrane protein
Tola_2176	COG1012	belongs to the aldehyde dehydrogenase family
Tola_2176	COG1454	alcohol dehydrogenase
Tola_2178	COG0861	Integral membrane protein TerC family
Tola_2179	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
Tola_2180	COG2890	protein-(glutamine-N5) methyltransferase activity
Tola_2181	COG2840	Smr protein MutS2
Tola_2183	COG2062	phosphohistidine phosphatase, SixA
Tola_2185	COG0084	hydrolase, TatD family'
Tola_2187	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
Tola_2188	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
Tola_2190	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
Tola_2191	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
Tola_2192	COG1028	Short-chain dehydrogenase reductase Sdr
Tola_2195	COG0416	fatty acid biosynthetic process
Tola_2196	COG0333	Belongs to the bacterial ribosomal protein bL32 family
Tola_2197	COG1399	metal-binding, possibly nucleic acid-binding protein
Tola_2199	COG0546	phosphoglycolate phosphatase activity
Tola_2200	COG0564	pseudouridine synthase activity
Tola_2201	COG1530	ribonuclease E activity
Tola_2202	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
Tola_2203	COG0589	response to stress
Tola_2204	COG0037	tRNA processing
Tola_2207	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
Tola_2208	COG0367	asparagine synthase
Tola_2209	COG1380	Effector of murein hydrolase LrgA
Tola_2210	COG1346	cytolysis
Tola_2212	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
Tola_2213	COG0563	adenylate kinase activity
Tola_2214	COG0326	Molecular chaperone. Has ATPase activity
Tola_2215	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
Tola_2216	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
Tola_2217	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
Tola_2218	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
Tola_2224	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
Tola_2227	COG0045	succinate-CoA ligase (ADP-forming) activity
Tola_2228	COG0508	dehydrogenase complex catalyzes the overall conversion of
Tola_2229	COG0567	Dehydrogenase, E1 component
Tola_2230	COG0372	Belongs to the citrate synthase family
Tola_2231	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
Tola_2232	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
Tola_2233	COG2835	tetraacyldisaccharide 4'-kinase activity
Tola_2234	COG1663	tetraacyldisaccharide 4'-kinase activity
Tola_2236	COG2333	competence protein COMEC
Tola_2236	COG0658	competence protein
Tola_2237	COG0586	Pfam SNARE associated Golgi protein
Tola_2238	COG4591	ABC-type transport system involved in lipoprotein release permease component
Tola_2239	COG1136	(ABC) transporter
Tola_2240	COG4591	ABC-type transport system involved in lipoprotein release permease component
Tola_2241	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
Tola_2242	COG1185	polyribonucleotide nucleotidyltransferase activity
Tola_2243	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
Tola_2244	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
Tola_2245	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
Tola_2246	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
Tola_2246	COG3064	Membrane
Tola_2247	COG0195	Participates in both transcription termination and antitermination
Tola_2248	COG0779	Required for maturation of 30S ribosomal subunits
Tola_2249	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
Tola_2250	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
Tola_2251	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
Tola_2252	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
Tola_2253	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
Tola_2254	COG1534	Rna-binding protein
Tola_2255	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
Tola_2256	COG0484	heat shock protein binding
Tola_2257	COG0443	Heat shock 70 kDa protein
Tola_2258	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
Tola_2259	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
Tola_2260	COG0497	DNA recombination
Tola_2261	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
Tola_2262	COG2914	Belongs to the UPF0125 (RnfH) family
Tola_2263	COG2867	negative regulation of translational initiation
Tola_2264	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
Tola_2265	COG0582	viral genome integration into host DNA
Tola_2273	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
Tola_2276	COG4983	Phage plasmid primase, P4 family domain protein
Tola_2277	COG3311	Transcriptional regulator
Tola_2280	COG5377	YqaJ viral recombinase family
Tola_2294	COG0590	tRNA wobble adenosine to inosine editing
Tola_2296	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
Tola_2297	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
Tola_2302	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
Tola_2303	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
Tola_2304	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
Tola_2305	COG0193	aminoacyl-tRNA hydrolase activity
Tola_2306	COG0012	GTP binding
Tola_2308	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
Tola_2309	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
Tola_2310	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
Tola_2311	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
Tola_2312	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
Tola_2313	COG1674	ftsk spoiiie
Tola_2313	COG0531	amino acid
Tola_2315	COG0686	Belongs to the AlaDH PNT family
Tola_2316	COG0492	ferredoxin-NADP+ reductase activity
Tola_2317	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
Tola_2318	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
Tola_2319	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
Tola_2320	COG0542	response to heat
Tola_2321	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
Tola_2322	COG1278	Cold shock
Tola_2323	COG0538	isocitrate dehydrogenase activity
Tola_2325	COG0482	sulfurtransferase activity
Tola_2326	COG2915	High frequency lysogenization protein hflD homolog
Tola_2327	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
Tola_2329	COG2205	protein histidine kinase activity
Tola_2330	COG4657	Part of a membrane complex involved in electron transport
Tola_2331	COG2878	Part of a membrane complex involved in electron transport
Tola_2334	COG4659	FMN binding
Tola_2339	COG0531	amino acid
Tola_2340	COG1408	metallophosphoesterase
Tola_2341	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
Tola_2347	COG0798	PFAM Bile acid sodium symporter
Tola_2349	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
Tola_2350	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
Tola_2353	COG0175	sulfate reduction
Tola_2354	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
Tola_2355	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
Tola_2357	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
Tola_2358	COG5001	Diguanylate cyclase
Tola_2362	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
Tola_2363	COG0564	pseudouridine synthase activity
Tola_2364	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
Tola_2365	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
Tola_2367	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
Tola_2368	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
Tola_2369	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
Tola_2370	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
Tola_2372	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
Tola_2374	COG3610	response to peptide
Tola_2375	COG2966	Psort location CytoplasmicMembrane, score
Tola_2376	COG1289	transmembrane transporter activity
Tola_2377	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
Tola_2378	COG0211	Belongs to the bacterial ribosomal protein bL27 family
Tola_2379	COG0261	This protein binds to 23S rRNA in the presence of protein L20
Tola_2380	COG0142	geranyltranstransferase activity
Tola_2381	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
Tola_2382	COG0330	HflC and HflK could
Tola_2383	COG0330	HflC and HflK could
Tola_2384	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
Tola_2385	COG1923	regulation of RNA biosynthetic process
Tola_2386	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
Tola_2387	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
Tola_2389	COG0802	atpase or kinase
Tola_2390	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
Tola_2390	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
Tola_2393	COG0330	HflC and HflK could
Tola_2396	COG1192	Involved in chromosome partitioning
Tola_2403	COG0629	single-stranded DNA binding
Tola_2404	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
Tola_2446	COG2003	Belongs to the UPF0758 family
Tola_2458	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
Tola_2459	COG2235	arginine
Tola_2460	COG1288	antiporter activity
Tola_2465	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
Tola_2466	COG0842	Transport permease protein
Tola_2466	COG1129	ABC transporter
Tola_2467	COG0842	Transport permease protein
Tola_2469	COG1028	Short-chain dehydrogenase reductase Sdr
Tola_2473	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
Tola_2474	COG0786	glutamate:sodium symporter activity
Tola_2475	COG3243	poly(R)-hydroxyalkanoic acid synthase
Tola_2476	COG0589	response to stress
Tola_2481	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
Tola_2482	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
Tola_2483	COG0583	DNA-binding transcription factor activity
Tola_2484	COG1396	sequence-specific DNA binding
Tola_2486	COG0582	viral genome integration into host DNA
Tola_2487	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
Tola_2488	COG1162	GTPase activity
Tola_2489	COG0688	phosphatidylethanolamine metabolic process
Tola_2490	COG1053	succinate dehydrogenase
Tola_2491	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
Tola_2492	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
Tola_2493	COG3080	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
Tola_2494	COG0516	GMP reductase activity
Tola_2496	COG0602	queuosine metabolic process
Tola_2497	COG0359	binds to the 23S rRNA
Tola_2498	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
Tola_2499	COG0360	Binds together with S18 to 16S ribosomal RNA
Tola_2500	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
Tola_2501	COG1482	cell wall glycoprotein biosynthetic process
Tola_2502	COG0301	tRNA thio-modification
Tola_2502	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
Tola_2503	COG1722	exodeoxyribonuclease VII activity
Tola_2504	COG0142	geranyltranstransferase activity
Tola_2505	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
Tola_2508	COG0679	Auxin Efflux Carrier
Tola_2510	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
Tola_2519	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
Tola_2520	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
Tola_2521	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
Tola_2522	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
Tola_2525	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
Tola_2525	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
Tola_2526	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
Tola_2527	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
Tola_2528	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
Tola_2529	COG0511	ligase activity, forming carbon-carbon bonds
Tola_2530	COG0439	Biotin carboxylase
Tola_2532	COG2264	protein methyltransferase activity
Tola_2533	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
Tola_2534	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
Tola_2535	COG2194	sulfuric ester hydrolase activity
Tola_2536	COG1119	ATPase activity
Tola_2539	COG0163	prenyltransferase activity
Tola_2540	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
Tola_2541	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
Tola_2543	COG0529	Catalyzes the synthesis of activated sulfate
Tola_2544	COG2895	sulfate adenylyltransferase (ATP) activity
Tola_2545	COG0175	sulfate reduction
Tola_2546	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
Tola_2546	COG1648	precorrin-2 dehydrogenase activity
Tola_2547	COG0330	HflC and HflK could
Tola_2548	COG1585	Membrane protein implicated in regulation of membrane protease activity
Tola_2549	COG0039	L-malate dehydrogenase activity
Tola_2550	COG1438	arginine binding
Tola_2551	COG3290	protein histidine kinase activity
Tola_2552	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
Tola_2552	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
Tola_2554	COG1053	succinate dehydrogenase
Tola_2556	COG4565	transcriptional regulatory protein
Tola_2557	COG3842	ATPase activity
Tola_2559	COG1840	ABC-type Fe3 transport system, periplasmic component
Tola_2560	COG0347	Belongs to the P(II) protein family
Tola_2561	COG3112	Uncharacterised protein family (UPF0231)
Tola_2562	COG1049	propionate catabolic process, 2-methylcitrate cycle
Tola_2564	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
Tola_2566	COG0446	pyridine nucleotide-disulphide oxidoreductase
Tola_2572	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
Tola_2573	COG2084	Dehydrogenase
Tola_2574	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
Tola_2575	COG0508	dehydrogenase complex catalyzes the overall conversion of
Tola_2576	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
Tola_2577	COG2186	Transcriptional regulator
Tola_2578	COG3835	regulator
Tola_2579	COG1929	Belongs to the glycerate kinase type-1 family
Tola_2580	COG2084	Dehydrogenase
Tola_2581	COG3836	Belongs to the HpcH HpaI aldolase family
Tola_2582	COG4948	Mandelate Racemase Muconate Lactonizing
Tola_2583	COG4948	Mandelate Racemase Muconate Lactonizing
Tola_2584	COG2271	Major facilitator Superfamily
Tola_2585	COG2721	sulfolactate sulfo-lyase activity
Tola_2586	COG3023	N-Acetylmuramoyl-L-alanine amidase
Tola_2588	COG0561	phosphatase activity
Tola_2589	COG1115	amino acid carrier protein
Tola_2590	COG0776	regulation of translation
Tola_2592	COG0739	heme binding
Tola_2593	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
Tola_2594	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
Tola_2595	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
Tola_2596	COG0560	Phosphoserine phosphatase
Tola_2597	COG0813	purine-nucleoside phosphorylase activity
Tola_2598	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
Tola_2599	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
Tola_2600	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
Tola_2601	COG0084	hydrolase, TatD family'
Tola_2606	COG0557	exoribonuclease II activity
Tola_2611	COG0180	Tryptophanyl-tRNA synthetase
Tola_2612	COG0546	phosphoglycolate phosphatase activity
Tola_2613	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
Tola_2614	COG0338	D12 class N6 adenine-specific DNA methyltransferase
Tola_2616	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
Tola_2617	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
Tola_2618	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
Tola_2619	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
Tola_2622	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
Tola_2628	COG2813	Specifically methylates the guanine in position
Tola_2629	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
Tola_2630	COG0297	glycogen (starch) synthase activity
Tola_2632	COG2017	converts alpha-aldose to the beta-anomer
Tola_2633	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
Tola_2634	COG1085	galactose-1-phosphate uridylyltransferase
Tola_2635	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
Tola_2636	COG1609	Transcriptional regulator
Tola_2638	COG1129	ABC transporter
Tola_2640	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
Tola_2641	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
Tola_2642	COG0649	NAD binding
Tola_2642	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
Tola_2643	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
Tola_2644	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
Tola_2645	COG1034	ATP synthesis coupled electron transport
Tola_2646	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
Tola_2647	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
Tola_2648	COG0839	Belongs to the complex I subunit 6 family
Tola_2649	COG0713	ATP synthesis coupled electron transport
Tola_2650	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
Tola_2651	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
Tola_2652	COG1007	ATP synthesis coupled electron transport
Tola_2653	COG2188	Transcriptional regulator
Tola_2654	COG1979	alcohol dehydrogenase
Tola_2655	COG1486	melibiose metabolic process
Tola_2656	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
Tola_2656	COG1263	PTS System
Tola_2657	COG0248	Ppx GppA phosphatase
Tola_2658	COG0513	Belongs to the DEAD box helicase family
Tola_2659	COG3118	belongs to the thioredoxin family
Tola_2660	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
Tola_2663	COG3409	Peptidoglycan-binding domain 1 protein
Tola_2663	COG3267	Type II secretory pathway component ExeA
Tola_2664	COG0617	tRNA 3'-terminal CCA addition
Tola_2666	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
Tola_2667	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
Tola_2668	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
Tola_2669	COG0828	Belongs to the bacterial ribosomal protein bS21 family
Tola_2671	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
Tola_2679	COG3561	AntA/AntB antirepressor
Tola_2682	COG0582	viral genome integration into host DNA
Tola_2683	COG4584	PFAM Integrase catalytic
Tola_2684	COG1484	DNA-dependent DNA replication
Tola_2687	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
Tola_2688	COG2027	D-alanyl-D-alanine carboxypeptidase
Tola_2689	COG0436	Aminotransferase
Tola_2690	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
Tola_2691	COG0778	Nitroreductase
Tola_2692	COG0616	signal peptide processing
Tola_2693	COG0252	asparaginase activity
Tola_2696	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
Tola_2697	COG1640	4-alpha-glucanotransferase
Tola_2698	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
Tola_2699	COG0676	glucose-6-phosphate 1-epimerase activity
Tola_2700	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
Tola_2702	COG2885	chlorophyll binding
Tola_2703	COG0823	Involved in the tonB-independent uptake of proteins
Tola_2704	COG3064	Membrane
Tola_2706	COG0811	peptide transport
Tola_2707	COG0824	Thioesterase
Tola_2708	COG4890	Cyd operon protein YbgT
Tola_2709	COG1294	oxidase, subunit
Tola_2711	COG2255	four-way junction helicase activity
Tola_2712	COG0632	four-way junction helicase activity
Tola_2713	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
Tola_2714	COG0217	transcriptional regulatory protein
Tola_2715	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
Tola_2717	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
Tola_2718	COG1702	phosphate starvation-inducible protein PhoH
Tola_2719	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
Tola_2720	COG4535	Mg2 and Co2 transporter CorC
Tola_2721	COG0815	Transfers the fatty acyl group on membrane lipoproteins
Tola_2722	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
Tola_2724	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
Tola_2726	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
Tola_2727	COG0305	Participates in initiation and elongation during chromosome replication
Tola_2728	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
Tola_2729	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
Tola_2730	COG2137	regulation of response to DNA damage stimulus
Tola_2731	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
Tola_2732	COG1546	Belongs to the CinA family
Tola_2733	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
Tola_2735	COG4942	peptidase
Tola_2735	COG1388	LysM domain
Tola_2736	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
Tola_2737	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
Tola_2738	COG0585	pseudouridine synthase activity
Tola_2740	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
Tola_2741	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
Tola_2742	COG0148	phosphopyruvate hydratase activity
Tola_2743	COG0504	CTP synthase activity
Tola_2744	COG3956	TIGRFAM MazG family protein
Tola_2745	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
Tola_2746	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
Tola_2750	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
Tola_2751	COG3089	Belongs to the UPF0270 family
Tola_2753	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
Tola_2754	COG0512	Glutamine amidotransferase of anthranilate synthase
Tola_2755	COG3012	SEC-C Motif Domain Protein
Tola_2756	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
Tola_2758	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
Tola_2759	COG3074	FtsZ-dependent cytokinesis
Tola_2761	COG1045	serine acetyltransferase
Tola_2762	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
Tola_2763	COG1177	transmembrane transport
Tola_2764	COG1176	ABC-type spermidine putrescine transport system, permease component I
Tola_2765	COG3842	ATPase activity
Tola_2766	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
Tola_2767	COG3045	CreA protein
Tola_2769	COG0542	response to heat
Tola_2771	COG0564	pseudouridine synthase activity
Tola_2772	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
Tola_2773	COG1803	Methylglyoxal synthase
Tola_2775	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
Tola_2776	COG0049	tRNA binding
Tola_2777	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
Tola_2780	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
Tola_2781	COG0251	oxidation-reduction process
Tola_2782	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
Tola_2783	COG0085	RNA polymerase activity
Tola_2784	COG0222	ribosome binding
Tola_2785	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
Tola_2786	COG0081	regulation of translation
Tola_2787	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
Tola_2788	COG0250	Participates in transcription elongation, termination and antitermination
Tola_2789	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
Tola_2791	COG1072	(Pantothenic acid kinase))
Tola_2794	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
Tola_2795	COG4137	Cytochrome C assembly protein
Tola_2796	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
Tola_2797	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
Tola_2798	COG0739	heme binding
Tola_2801	COG0714	Associated with various cellular activities
Tola_2802	COG2425	protein containing a von Willebrand factor type A (vWA) domain
Tola_2803	COG0540	Belongs to the ATCase OTCase family
Tola_2804	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
Tola_2805	COG2814	Major facilitator Superfamily
Tola_2806	COG4651	solute:proton antiporter activity
Tola_2806	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
Tola_2807	COG3133	Outer membrane lipoprotein
Tola_2809	COG1671	Belongs to the UPF0178 family
Tola_2810	COG0826	peptidase U32
Tola_2811	COG5002	protein histidine kinase activity
Tola_2811	COG3447	MASE1 domain protein
Tola_2811	COG5001	Diguanylate cyclase
Tola_2813	COG0459	protein refolding
Tola_2814	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
Tola_2816	COG1324	tolerance protein
Tola_2819	COG0733	neurotransmitter:sodium symporter activity
Tola_2821	COG1686	Belongs to the peptidase S11 family
Tola_2823	COG0495	leucyl-tRNA aminoacylation
Tola_2825	COG1466	dna polymerase III delta subunit
Tola_2826	COG0799	negative regulation of ribosome biogenesis
Tola_2827	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
Tola_2828	COG0768	penicillin binding
Tola_2829	COG0772	Belongs to the SEDS family
Tola_2830	COG2951	lytic endotransglycosylase activity
Tola_2831	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
Tola_2832	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
Tola_2833	COG1686	Belongs to the peptidase S11 family
Tola_2834	COG2921	Belongs to the UPF0250 family
Tola_2835	COG0321	lipoyl(octanoyl) transferase activity
Tola_2836	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
Tola_2837	COG2949	membrane
Tola_2839	COG5001	Diguanylate cyclase
Tola_2839	COG3300	MHYT domain
Tola_2851	COG2026	Addiction module toxin, RelE StbE family
Tola_2855	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
Tola_2871	COG3384	dioxygenase
Tola_2876	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
Tola_2877	COG0583	DNA-binding transcription factor activity
Tola_2879	COG3647	Membrane
Tola_2883	COG0246	Mannitol dehydrogenase
Tola_2884	COG1312	Catalyzes the dehydration of D-mannonate
Tola_2885	COG2271	Major facilitator Superfamily
Tola_2887	COG2186	Transcriptional regulator
Tola_2896	COG3250	beta-galactosidase activity
Tola_2897	COG0583	DNA-binding transcription factor activity
Tola_2899	COG0439	Biotin carboxylase
Tola_2902	COG3842	ATPase activity
Tola_2905	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
Tola_2907	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
Tola_2908	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
Tola_2909	COG1115	amino acid carrier protein
Tola_2911	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
Tola_2912	COG0735	belongs to the Fur family
Tola_2913	COG1121	(ABC) transporter
Tola_2915	COG0803	Belongs to the bacterial solute-binding protein 9 family
Tola_2917	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
Tola_2918	COG1854	S-ribosylhomocysteine lyase activity
Tola_2921	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
Tola_2922	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
Tola_2924	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
Tola_2925	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
Tola_2926	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
Tola_2927	COG5007	Belongs to the BolA IbaG family
Tola_2929	COG2854	intermembrane phospholipid transfer
Tola_2930	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
Tola_2931	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
Tola_2932	COG1127	ABC transporter
Tola_2933	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
Tola_2933	COG0517	IMP dehydrogenase activity
Tola_2934	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
Tola_2936	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
Tola_2937	COG1137	ATPase activity
Tola_2938	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
Tola_2940	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
Tola_2941	COG1660	Displays ATPase and GTPase activities
Tola_2942	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
Tola_2943	COG0583	DNA-binding transcription factor activity
Tola_2945	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
Tola_2951	COG4968	Prepilin-type N-terminal cleavage methylation domain
Tola_2952	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
Tola_2953	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
Tola_2954	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
Tola_2955	COG0196	riboflavin kinase activity
Tola_2956	COG0728	peptidoglycan biosynthetic process
Tola_2957	COG0268	Binds directly to 16S ribosomal RNA
Tola_2958	COG0640	Transcriptional regulator
Tola_2959	COG0583	DNA-binding transcription factor activity
Tola_2960	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
Tola_2961	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
Tola_2963	COG0494	nUDIX hydrolase
Tola_2964	COG3066	DNA modification
Tola_2966	COG0335	large ribosomal subunit rRNA binding
Tola_2967	COG0336	Belongs to the RNA methyltransferase TrmD family
Tola_2968	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
Tola_2969	COG0228	four-way junction DNA binding
Tola_2970	COG0724	RNA recognition motif
Tola_2972	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
Tola_2973	COG3084	Protein conserved in bacteria
Tola_2975	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
Tola_2977	COG2960	long-chain fatty acid transporting porin activity
Tola_2978	COG0514	ATP-dependent DNA helicase (RecQ)
Tola_2980	COG2962	Rard protein
Tola_2982	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
Tola_2983	COG1447	Phosphotransferase system cellobiose-specific component IIA
Tola_2984	COG2723	6-phospho-beta-galactosidase activity
Tola_2986	COG1609	Transcriptional regulator
Tola_2987	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
Tola_2988	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
Tola_2991	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
Tola_2993	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
Tola_2994	COG1805	sodium ion transport
Tola_2995	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
Tola_2996	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
Tola_2997	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
Tola_2998	COG2871	sodium ion transport
Tola_3000	COG0742	ribosomal rna small subunit methyltransferase
Tola_3002	COG0006	proline dipeptidase activity
Tola_3003	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
Tola_3005	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
Tola_3006	COG1027	Aspartate ammonia-lyase
Tola_3007	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
Tola_3009	COG0288	reversible hydration of carbon dioxide
Tola_3011	COG2177	Part of the ABC transporter FtsEX involved in
Tola_3012	COG2884	Cell division ATP-binding protein ftsE
Tola_3013	COG0552	protein localization to endoplasmic reticulum
Tola_3014	COG0742	ribosomal rna small subunit methyltransferase
Tola_3016	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
Tola_3017	COG2205	protein histidine kinase activity
Tola_3018	COG0745	RESPONSE REGULATOR receiver
Tola_3020	COG1444	tRNA N-acetyltransferase activity
Tola_3021	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
Tola_3022	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
Tola_3024	COG2271	Major facilitator Superfamily
Tola_3026	COG0246	Mannitol dehydrogenase
Tola_3027	COG2721	sulfolactate sulfo-lyase activity
Tola_3035	COG2856	Zn peptidase
Tola_3038	COG0730	response to heat
Tola_3041	COG0006	proline dipeptidase activity
Tola_3044	COG2731	YhcH YjgK YiaL family protein
Tola_3046	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
Tola_3047	COG0800	Aldolase
Tola_3048	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
Tola_3049	COG1028	Short-chain dehydrogenase reductase Sdr
Tola_3051	COG0204	Acyl-transferase
Tola_3052	COG0714	Associated with various cellular activities
Tola_3057	COG1785	Belongs to the alkaline phosphatase family
Tola_3059	COG0606	chelatase, subunit chli
Tola_3060	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
Tola_3063	COG3623	hexulose-6-phosphate isomerase
Tola_3064	COG0561	phosphatase activity
Tola_3067	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
Tola_3069	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
Tola_3070	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
Tola_3083	COG2390	Transcriptional regulator
Tola_3084	COG0246	Mannitol dehydrogenase
Tola_3085	COG1070	Carbohydrate kinase
Tola_3087	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
Tola_3089	COG4067	protein conserved in archaea
Tola_3089	COG0189	ligase activity
Tola_3091	COG3978	acetolactate synthase activity
Tola_3092	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
Tola_3093	COG0129	dihydroxy-acid dehydratase activity
Tola_3098	COG0583	DNA-binding transcription factor activity
Tola_3099	COG0477	Major facilitator Superfamily
Tola_3100	COG1609	Transcriptional regulator
Tola_3101	COG2723	6-phospho-beta-galactosidase activity
Tola_3102	COG1447	Phosphotransferase system cellobiose-specific component IIA
Tola_3103	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
Tola_3104	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
Tola_3105	COG2723	6-phospho-beta-galactosidase activity
Tola_3106	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
Tola_3106	COG2190	(PTS) system
Tola_3106	COG1263	PTS System
Tola_3107	COG2272	Belongs to the type-B carboxylesterase lipase family
Tola_3109	COG2193	ferroxidase activity
Tola_3113	COG1061	Type III restriction enzyme res subunit
Tola_3114	COG1396	sequence-specific DNA binding
Tola_3115	COG3550	peptidyl-serine autophosphorylation
Tola_3116	COG1797	cobyrinic acid a,c-diamide synthase activity
Tola_3117	COG1492	cobalamin metabolic process
Tola_3118	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
Tola_3119	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
Tola_3121	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
Tola_3122	COG0019	diaminopimelate decarboxylase activity
Tola_3123	COG1965	Belongs to the frataxin family
Tola_3126	COG3072	Adenylate cyclase
Tola_3127	COG0181	hydroxymethylbilane synthase activity
Tola_3128	COG1587	Uroporphyrinogen-III synthase
Tola_3129	COG2959	enzyme of heme biosynthesis
Tola_3130	COG3071	HemY protein
Tola_3131	COG0004	ammonium transporteR
Tola_3132	COG0355	proton-transporting ATP synthase activity, rotational mechanism
Tola_3133	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
Tola_3134	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
Tola_3135	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
Tola_3136	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
Tola_3137	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
Tola_3139	COG0356	it plays a direct role in the translocation of protons across the membrane
Tola_3141	COG1475	DNA binding
Tola_3142	COG1192	Involved in chromosome partitioning
Tola_3143	COG0357	Ribosomal RNA small subunit methyltransferase G
Tola_3144	COG0445	tRNA wobble uridine modification
Tola_3146	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
Tola_3147	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
Tola_3150	COG0628	permease
Tola_3151	COG0583	DNA-binding transcription factor activity
Tola_3153	COG3530	Putative quorum-sensing-regulated virulence factor
Tola_3155	COG1902	pentaerythritol trinitrate reductase activity
Tola_3156	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
Tola_3157	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
Tola_3158	COG0698	ribose 5-phosphate isomerase
Tola_3160	COG3395	kinase activity
Tola_3162	COG0149	triose-phosphate isomerase activity
Tola_3163	COG2390	Transcriptional regulator
Tola_3166	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
Tola_3167	COG0706	membrane insertase activity
Tola_3168	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
Tola_3169	COG0594	ribonuclease P activity
Tola_3170	COG0230	Belongs to the bacterial ribosomal protein bL34 family
Tola_3171	COG0204	Acyl-transferase
Tola_3171	COG0318	PFAM AMP-dependent synthetase and ligase