locus-tag	class	description
HG267_00040	COG2205	protein histidine kinase activity
HG267_00040	COG3437	response regulator, receiver
HG267_00040	COG3850	Histidine kinase
HG267_00040	COG4999	Histidine kinase
HG267_00060	COG0288	reversible hydration of carbon dioxide
HG267_00070	COG0653	protein targeting
HG267_00100	COG3852	Histidine kinase
HG267_00105	COG0820	rRNA (adenine-C2-)-methyltransferase activity
HG267_00125	COG0322	excinuclease ABC activity
HG267_00135	COG0436	Aminotransferase
HG267_00140	COG3118	belongs to the thioredoxin family
HG267_00150	COG1842	Phage shock protein A
HG267_00155	COG1842	Phage shock protein A
HG267_00220	COG0124	histidyl-tRNA synthetase
HG267_00230	COG0251	oxidation-reduction process
HG267_00240	COG3246	L-lysine catabolic process to acetate
HG267_00260	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HG267_00265	COG0515	serine threonine protein kinase
HG267_00265	COG2815	serine threonine protein kinase
HG267_00290	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HG267_00295	COG0667	Aldo Keto reductase
HG267_00335	COG4095	Psort location CytoplasmicMembrane, score
HG267_00340	COG4999	Histidine kinase
HG267_00340	COG3850	Histidine kinase
HG267_00340	COG2205	protein histidine kinase activity
HG267_00340	COG3437	response regulator, receiver
HG267_00345	COG2197	response regulator
HG267_00385	COG0071	Belongs to the small heat shock protein (HSP20) family
HG267_00410	COG0840	transmembrane signaling receptor activity
HG267_00410	COG2203	Gaf domain
HG267_00415	COG0784	Response regulator, receiver
HG267_00455	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HG267_00460	COG1121	(ABC) transporter
HG267_00475	COG0583	DNA-binding transcription factor activity
HG267_00480	COG2988	succinylglutamate desuccinylase activity
HG267_00485	COG3706	GGDEF domain
HG267_00485	COG4251	negative regulation of phosphorylation
HG267_00485	COG5001	Diguanylate cyclase
HG267_00485	COG2203	Gaf domain
HG267_00495	COG3546	catalase activity
HG267_00500	COG2261	transglycosylase associated protein
HG267_00520	COG0457	Tetratricopeptide repeat
HG267_00520	COG0463	Glycosyl transferase, family 2
HG267_00525	COG0436	Aminotransferase
HG267_00540	COG1230	cation diffusion facilitator family transporter
HG267_00545	COG0518	GMP synthase (glutamine-hydrolyzing) activity
HG267_00545	COG0519	Catalyzes the synthesis of GMP from XMP
HG267_00550	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
HG267_00575	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
HG267_00580	COG0220	tRNA (guanine-N7-)-methyltransferase activity
HG267_00585	COG4603	Belongs to the binding-protein-dependent transport system permease family
HG267_00590	COG1079	Belongs to the binding-protein-dependent transport system permease family
HG267_00605	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HG267_00615	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HG267_00620	COG0765	amino acid transport
HG267_00625	COG1126	abc transporter atp-binding protein
HG267_00640	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HG267_00645	COG2319	Wd-40 repeat
HG267_00645	COG5635	Nacht domain
HG267_00695	COG0793	Belongs to the peptidase S41A family
HG267_00700	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
HG267_00705	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
HG267_00715	COG0438	transferase activity, transferring glycosyl groups
HG267_00730	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
HG267_00735	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
HG267_00740	COG1959	2 iron, 2 sulfur cluster binding
HG267_00750	COG0038	chloride channel
HG267_00760	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
HG267_00820	COG0375	protein maturation
HG267_00825	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
HG267_00835	COG2205	protein histidine kinase activity
HG267_00835	COG2198	Histidine kinase
HG267_00835	COG0784	Response regulator, receiver
HG267_00850	COG2205	protein histidine kinase activity
HG267_00850	COG2202	Pas domain
HG267_00990	COG0515	serine threonine protein kinase
HG267_00995	COG0515	serine threonine protein kinase
HG267_00995	COG3266	domain, Protein
HG267_01020	COG3239	Fatty acid desaturase
HG267_01050	COG0659	secondary active sulfate transmembrane transporter activity
HG267_01070	COG0515	serine threonine protein kinase
HG267_01070	COG1357	PFAM Pentapeptide repeats (8 copies)
HG267_01075	COG0737	Belongs to the 5'-nucleotidase family
HG267_01080	COG1649	PFAM Uncharacterised BCR, COG1649
HG267_01105	COG3903	Transcriptional regulator
HG267_01105	COG2319	Wd-40 repeat
HG267_01110	COG4221	oxidoreductase activity
HG267_01140	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
HG267_01145	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
HG267_01200	COG0667	Aldo Keto reductase
HG267_01205	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
HG267_01210	COG4106	trans-aconitate 2-methyltransferase activity
HG267_01240	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
HG267_01250	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HG267_01260	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HG267_01275	COG2217	Heavy metal translocating P-type atpase
HG267_01285	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
HG267_01295	COG0515	serine threonine protein kinase
HG267_01320	COG0659	secondary active sulfate transmembrane transporter activity
HG267_01330	COG0347	Belongs to the P(II) protein family
HG267_01335	COG0475	glutathione-regulated potassium exporter activity
HG267_01345	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HG267_01350	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HG267_01355	COG1116	anion transmembrane transporter activity
HG267_01355	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HG267_01360	COG1116	anion transmembrane transporter activity
HG267_01395	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
HG267_01405	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
HG267_01410	COG3852	Histidine kinase
HG267_01440	COG0438	transferase activity, transferring glycosyl groups
HG267_01490	COG2994	toxin metabolic process
HG267_01500	COG0432	Pfam Uncharacterised protein family UPF0047
HG267_01515	COG3000	fatty acid hydroxylase
HG267_01515	COG0300	oxidoreductase activity
HG267_01520	COG0723	plastoquinol--plastocyanin reductase activity
HG267_01540	COG1461	Dihydroxyacetone kinase
HG267_01550	COG2376	Dihydroxyacetone kinase
HG267_01560	COG0625	glutathione transferase activity
HG267_01570	COG0242	peptide deformylase activity
HG267_01575	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HG267_01580	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
HG267_01605	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HG267_01620	COG2022	thiamine diphosphate biosynthetic process
HG267_01620	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HG267_01635	COG0004	ammonium transporteR
HG267_01640	COG1357	PFAM Pentapeptide repeats (8 copies)
HG267_01640	COG0515	serine threonine protein kinase
HG267_01645	COG2319	Wd-40 repeat
HG267_01645	COG3903	Transcriptional regulator
HG267_01650	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
HG267_01655	COG0004	ammonium transporteR
HG267_01675	COG0003	Pfam Anion-transporting ATPase
HG267_01680	COG4251	negative regulation of phosphorylation
HG267_01680	COG3706	GGDEF domain
HG267_01680	COG2203	Gaf domain
HG267_01680	COG5001	Diguanylate cyclase
HG267_01680	COG4251	negative regulation of phosphorylation
HG267_01680	COG3706	GGDEF domain
HG267_01680	COG2203	Gaf domain
HG267_01680	COG5001	Diguanylate cyclase
HG267_01685	COG0592	DNA-directed DNA polymerase activity
HG267_01690	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
HG267_01705	COG0701	Predicted permease
HG267_01710	COG3852	Histidine kinase
HG267_01725	COG1028	Short-chain dehydrogenase reductase Sdr
HG267_01760	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
HG267_01775	COG2885	chlorophyll binding
HG267_01780	COG2885	chlorophyll binding
HG267_01790	COG2066	Belongs to the glutaminase family
HG267_01815	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HG267_01835	COG4585	Histidine kinase
HG267_01840	COG2197	response regulator
HG267_01850	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HG267_01870	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HG267_01875	COG3629	intracellular signal transduction
HG267_01875	COG3903	Transcriptional regulator
HG267_01910	COG2048	Heterodisulfide reductase, subunit B
HG267_01915	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HG267_01920	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HG267_01925	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
HG267_02000	COG1361	Conserved repeat domain
HG267_02000	COG2911	Protein conserved in bacteria
HG267_02000	COG3266	domain, Protein
HG267_02025	COG0288	reversible hydration of carbon dioxide
HG267_02030	COG5002	protein histidine kinase activity
HG267_02035	COG0745	RESPONSE REGULATOR receiver
HG267_02080	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
HG267_02085	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
HG267_02095	COG0450	alkyl hydroperoxide reductase
HG267_02100	COG0438	transferase activity, transferring glycosyl groups
HG267_02110	COG0438	transferase activity, transferring glycosyl groups
HG267_02130	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HG267_02140	COG5398	heme oxygenase
HG267_02195	COG0625	glutathione transferase activity
HG267_02210	COG3118	belongs to the thioredoxin family
HG267_02215	COG0640	Transcriptional regulator
HG267_02255	COG1028	Short-chain dehydrogenase reductase Sdr
HG267_02260	COG0587	DNA-directed DNA polymerase activity
HG267_02265	COG1301	dicarboxylic acid transport
HG267_02275	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
HG267_02290	COG0463	Glycosyl transferase, family 2
HG267_02310	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
HG267_02320	COG5002	protein histidine kinase activity
HG267_02325	COG1032	radical SAM domain protein
HG267_02335	COG1309	transcriptional regulator
HG267_02345	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
HG267_02350	COG0784	Response regulator, receiver
HG267_02350	COG5002	protein histidine kinase activity
HG267_02350	COG2205	protein histidine kinase activity
HG267_02355	COG1196	nuclear chromosome segregation
HG267_02390	COG1960	acyl-CoA dehydrogenase activity
HG267_02395	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HG267_02400	COG0431	NADPH-dependent FMN reductase
HG267_02405	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
HG267_02410	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
HG267_02420	COG2205	protein histidine kinase activity
HG267_02420	COG3437	response regulator, receiver
HG267_02420	COG3850	Histidine kinase
HG267_02420	COG4999	Histidine kinase
HG267_02430	COG0515	serine threonine protein kinase
HG267_02455	COG3621	Patatin-like phospholipase
HG267_02620	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HG267_02620	COG1116	anion transmembrane transporter activity
HG267_02625	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HG267_02630	COG0515	serine threonine protein kinase
HG267_02630	COG1357	PFAM Pentapeptide repeats (8 copies)
HG267_02660	COG0445	tRNA wobble uridine modification
HG267_02675	COG0730	response to heat
HG267_02695	COG0371	Dehydrogenase
HG267_02700	COG0436	Aminotransferase
HG267_02710	COG2319	Wd-40 repeat
HG267_02710	COG1672	PFAM Archaeal ATPase
HG267_02715	COG0515	serine threonine protein kinase
HG267_02730	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
HG267_02735	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HG267_02745	COG0798	PFAM Bile acid sodium symporter
HG267_02755	COG0346	lactoylglutathione lyase activity
HG267_02760	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HG267_02770	COG1872	DUF167
HG267_02775	COG0625	glutathione transferase activity
HG267_02780	COG2135	peptidase activity
HG267_02785	COG0457	Tetratricopeptide repeat
HG267_02790	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HG267_02795	COG0435	Glutathione S-transferase
HG267_02820	COG1215	transferase activity, transferring glycosyl groups
HG267_02855	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HG267_02865	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HG267_02890	COG1027	Aspartate ammonia-lyase
HG267_02895	COG2006	4fe-4S ferredoxin, iron-sulfur binding domain protein
HG267_02910	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
HG267_02915	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
HG267_02925	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HG267_02930	COG0583	DNA-binding transcription factor activity
HG267_02940	COG3093	addiction module antidote protein HigA
HG267_02955	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HG267_02980	COG1672	PFAM Archaeal ATPase
HG267_02980	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
HG267_03050	COG0714	Associated with various cellular activities
HG267_03075	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
HG267_03085	COG0828	Belongs to the bacterial ribosomal protein bS21 family
HG267_03090	COG0193	aminoacyl-tRNA hydrolase activity
HG267_03095	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HG267_03135	COG2208	phosphoserine phosphatase activity
HG267_03140	COG0552	protein localization to endoplasmic reticulum
HG267_03145	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HG267_03170	COG4968	Prepilin-type N-terminal cleavage methylation domain
HG267_03175	COG1215	transferase activity, transferring glycosyl groups
HG267_03200	COG0227	Belongs to the bacterial ribosomal protein bL28 family
HG267_03215	COG2226	methyltransferase
HG267_03225	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HG267_03240	COG1216	Glycosyl transferase, family 2
HG267_03240	COG0463	Glycosyl transferase, family 2
HG267_03245	COG1215	transferase activity, transferring glycosyl groups
HG267_03275	COG0515	serine threonine protein kinase
HG267_03290	COG0439	Biotin carboxylase
HG267_03320	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HG267_03340	COG0719	Fe-S assembly protein
HG267_03345	COG0396	ATPase activity
HG267_03350	COG0719	Fe-S assembly protein
HG267_03355	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HG267_03370	COG1132	(ABC) transporter
HG267_03385	COG2010	Cytochrome c
HG267_03395	COG0742	ribosomal rna small subunit methyltransferase
HG267_03400	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
HG267_03405	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
HG267_03425	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
HG267_03430	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
HG267_03480	COG0123	including yeast histone deacetylase and acetoin utilization protein
HG267_03490	COG3266	domain, Protein
HG267_03490	COG0515	serine threonine protein kinase
HG267_03500	COG4932	domain protein
HG267_03505	COG2885	chlorophyll binding
HG267_03525	COG1357	PFAM Pentapeptide repeats (8 copies)
HG267_03525	COG0515	serine threonine protein kinase
HG267_03535	COG0300	oxidoreductase activity
HG267_03540	COG3634	alkyl hydroperoxide reductase activity
HG267_03565	COG0363	glucosamine-6-phosphate deaminase activity
HG267_03590	COG1528	Iron-storage protein
HG267_03600	COG3447	MASE1 domain protein
HG267_03600	COG5001	Diguanylate cyclase
HG267_03600	COG5002	protein histidine kinase activity
HG267_03605	COG5002	protein histidine kinase activity
HG267_03640	COG0354	folic acid binding
HG267_03655	COG1131	(ABC) transporter
HG267_03695	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
HG267_03715	COG0095	Lipoate-protein ligase
HG267_03730	COG3657	addiction module killer protein
HG267_03750	COG2226	methyltransferase
HG267_03765	COG2515	1-aminocyclopropane-1-carboxylate deaminase
HG267_03780	COG0438	transferase activity, transferring glycosyl groups
HG267_03785	COG1177	transmembrane transport
HG267_03790	COG1357	PFAM Pentapeptide repeats (8 copies)
HG267_03790	COG0515	serine threonine protein kinase
HG267_03805	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
HG267_03810	COG2201	protein-glutamate methylesterase activity
HG267_03825	COG0840	transmembrane signaling receptor activity
HG267_03825	COG2203	Gaf domain
HG267_03830	COG2198	Histidine kinase
HG267_03830	COG0643	Histidine kinase
HG267_03830	COG0784	Response regulator, receiver
HG267_03845	COG5001	Diguanylate cyclase
HG267_03845	COG4251	negative regulation of phosphorylation
HG267_03845	COG3706	GGDEF domain
HG267_03845	COG2203	Gaf domain
HG267_03850	COG1176	ABC-type spermidine putrescine transport system, permease component I
HG267_03865	COG3842	ATPase activity
HG267_03870	COG0768	penicillin binding
HG267_03875	COG0768	penicillin binding
HG267_03895	COG0602	queuosine metabolic process
HG267_03910	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HG267_03920	COG4597	amino acid ABC transporter
HG267_03925	COG0765	amino acid transport
HG267_03930	COG1126	abc transporter atp-binding protein
HG267_03935	COG0297	glycogen (starch) synthase activity
HG267_03940	COG0799	negative regulation of ribosome biogenesis
HG267_03970	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
HG267_03975	COG1381	Involved in DNA repair and RecF pathway recombination
HG267_03985	COG0438	transferase activity, transferring glycosyl groups
HG267_03990	COG0683	leucine binding
HG267_04010	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
HG267_04015	COG0488	(ABC) transporter
HG267_04040	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
HG267_04045	COG0254	rRNA binding
HG267_04050	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
HG267_04060	COG0101	tRNA pseudouridine synthase activity
HG267_04065	COG0203	ribosomal protein L17
HG267_04070	COG0202	RNA polymerase activity
HG267_04075	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
HG267_04080	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
HG267_04085	COG0257	Belongs to the bacterial ribosomal protein bL36 family
HG267_04090	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
HG267_04095	COG0563	adenylate kinase activity
HG267_04100	COG0201	protein transport
HG267_04105	COG0200	Binds to the 23S rRNA
HG267_04110	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
HG267_04115	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
HG267_04120	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
HG267_04125	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
HG267_04130	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
HG267_04135	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
HG267_04140	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
HG267_04145	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
HG267_04150	COG0255	Belongs to the universal ribosomal protein uL29 family
HG267_04160	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
HG267_04165	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
HG267_04170	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
HG267_04175	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
HG267_04180	COG0089	rRNA binding
HG267_04185	COG0088	Forms part of the polypeptide exit tunnel
HG267_04190	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
HG267_04235	COG0784	Response regulator, receiver
HG267_04235	COG2198	Histidine kinase
HG267_04235	COG5002	protein histidine kinase activity
HG267_04265	COG0438	transferase activity, transferring glycosyl groups
HG267_04275	COG1215	transferase activity, transferring glycosyl groups
HG267_04290	COG1196	nuclear chromosome segregation
HG267_04290	COG1674	ftsk spoiiie
HG267_04295	COG1192	Involved in chromosome partitioning
HG267_04300	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
HG267_04315	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
HG267_04330	COG0180	Tryptophanyl-tRNA synthetase
HG267_04355	COG0515	serine threonine protein kinase
HG267_04355	COG2815	serine threonine protein kinase
HG267_04400	COG1968	undecaprenyl-diphosphatase activity
HG267_04415	COG2205	protein histidine kinase activity
HG267_04415	COG2198	Histidine kinase
HG267_04415	COG0784	Response regulator, receiver
HG267_04415	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HG267_04420	COG3300	MHYT domain
HG267_04420	COG5001	Diguanylate cyclase
HG267_04435	COG0662	Cupin 2, conserved barrel domain protein
HG267_04435	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
HG267_04440	COG3659	wide pore channel activity
HG267_04445	COG1172	Belongs to the binding-protein-dependent transport system permease family
HG267_04450	COG1129	ABC transporter
HG267_04455	COG1879	ABC-type sugar transport system periplasmic component
HG267_04460	COG1879	ABC-type sugar transport system periplasmic component
HG267_04470	COG3265	gluconokinase activity
HG267_04475	COG1609	Transcriptional regulator
HG267_04480	COG1904	glucuronate isomerase
HG267_04485	COG1028	Short-chain dehydrogenase reductase Sdr
HG267_04500	COG2205	protein histidine kinase activity
HG267_04560	COG2319	Wd-40 repeat
HG267_04560	COG4249	Peptidase C14 caspase catalytic subunit p20
HG267_04565	COG1830	Aldolase
HG267_04570	COG0724	RNA recognition motif
HG267_04575	COG0828	Belongs to the bacterial ribosomal protein bS21 family
HG267_04605	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
HG267_04610	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
HG267_04615	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HG267_04620	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
HG267_04625	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
HG267_04635	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HG267_04640	COG0356	it plays a direct role in the translocation of protons across the membrane
HG267_04655	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HG267_04760	COG1028	Short-chain dehydrogenase reductase Sdr
HG267_04765	COG2264	protein methyltransferase activity
HG267_04770	COG0531	amino acid
HG267_04775	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HG267_04785	COG2095	MarC family integral membrane protein
HG267_04815	COG5002	protein histidine kinase activity
HG267_04815	COG0784	Response regulator, receiver
HG267_04815	COG2198	Histidine kinase
HG267_04825	COG1136	(ABC) transporter
HG267_04825	COG0577	efflux transmembrane transporter activity
HG267_04840	COG1309	transcriptional regulator
HG267_04860	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
HG267_04875	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HG267_04895	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
HG267_04905	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HG267_04915	COG4572	Cation transport regulator
HG267_04920	COG2814	Major facilitator Superfamily
HG267_04950	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
HG267_04955	COG1233	COG1233 Phytoene dehydrogenase and related
HG267_04965	COG1192	Involved in chromosome partitioning
HG267_04970	COG1408	metallophosphoesterase
HG267_04975	COG1408	metallophosphoesterase
HG267_04985	COG2046	Belongs to the sulfate adenylyltransferase family
HG267_05000	COG1042	CoA-binding domain protein
HG267_05000	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HG267_05000	COG0045	succinate-CoA ligase (ADP-forming) activity
HG267_05010	COG3259	Nickel-dependent hydrogenase
HG267_05015	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HG267_05020	COG1034	ATP synthesis coupled electron transport
HG267_05025	COG1151	hydroxylamine reductase activity
HG267_05035	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HG267_05080	COG0352	thiamine-phosphate diphosphorylase activity
HG267_05085	COG4974	Belongs to the 'phage' integrase family
HG267_05095	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
HG267_05100	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
HG267_05105	COG4208	sulfate ABC transporter
HG267_05115	COG2385	sporulation resulting in formation of a cellular spore
HG267_05125	COG0557	exoribonuclease II activity
HG267_05130	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
HG267_05135	COG0267	Belongs to the bacterial ribosomal protein bL33 family
HG267_05145	COG0303	'Molybdopterin
HG267_05150	COG5002	protein histidine kinase activity
HG267_05155	COG0395	ABC-type sugar transport system, permease component
HG267_05160	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HG267_05175	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HG267_05185	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
HG267_05235	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
HG267_05250	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
HG267_05265	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
HG267_05320	COG2319	Wd-40 repeat
HG267_05320	COG1672	PFAM Archaeal ATPase
HG267_05335	COG0772	Belongs to the SEDS family
HG267_05370	COG0297	glycogen (starch) synthase activity
HG267_05375	COG1429	ligase activity, forming nitrogen-metal bonds
HG267_05385	COG0860	N-Acetylmuramoyl-L-alanine amidase
HG267_05440	COG1489	DNA binding
HG267_05465	COG0235	Class ii aldolase
HG267_05470	COG4359	Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene)
HG267_05475	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
HG267_05490	COG0205	6-phosphofructokinase activity
HG267_05555	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
HG267_05560	COG1132	(ABC) transporter
HG267_05565	COG1132	(ABC) transporter
HG267_05575	COG1028	Short-chain dehydrogenase reductase Sdr
HG267_05580	COG2815	serine threonine protein kinase
HG267_05580	COG0515	serine threonine protein kinase
HG267_05590	COG0284	orotidine-5'-phosphate decarboxylase activity
HG267_05595	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
HG267_05600	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HG267_05625	COG0681	Belongs to the peptidase S26 family
HG267_05640	COG0542	response to heat
HG267_05645	COG0456	acetyltransferase
HG267_05650	COG0019	diaminopimelate decarboxylase activity
HG267_05655	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
HG267_05660	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
HG267_05670	COG0484	heat shock protein binding
HG267_05715	COG0315	cyclic pyranopterin monophosphate synthase activity
HG267_05725	COG2814	Major facilitator Superfamily
HG267_05730	COG0574	Belongs to the PEP-utilizing enzyme family
HG267_05730	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HG267_05740	COG0589	response to stress
HG267_05745	COG0469	pyruvate kinase activity
HG267_05795	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
HG267_05810	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HG267_05820	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HG267_05825	COG1049	propionate catabolic process, 2-methylcitrate cycle
HG267_05830	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
HG267_05835	COG0587	DNA-directed DNA polymerase activity
HG267_05885	COG0175	sulfate reduction
HG267_05900	COG1570	exodeoxyribonuclease VII activity
HG267_05905	COG1722	exodeoxyribonuclease VII activity
HG267_05930	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HG267_05930	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
HG267_05935	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
HG267_05970	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
HG267_05980	COG0438	transferase activity, transferring glycosyl groups
HG267_05985	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HG267_06005	COG0300	oxidoreductase activity
HG267_06025	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
HG267_06035	COG4221	oxidoreductase activity
HG267_06050	COG1028	Short-chain dehydrogenase reductase Sdr
HG267_06075	COG1040	competence protein
HG267_06085	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
HG267_06095	COG0343	queuine tRNA-ribosyltransferase activity
HG267_06120	COG0589	response to stress
HG267_06125	COG0784	Response regulator, receiver
HG267_06125	COG2205	protein histidine kinase activity
HG267_06130	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
HG267_06130	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HG267_06145	COG2267	carboxylic ester hydrolase activity
HG267_06155	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HG267_06160	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
HG267_06170	COG0505	Belongs to the CarA family
HG267_06180	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HG267_06190	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
HG267_06215	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HG267_06215	COG0189	ligase activity
HG267_06225	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
HG267_06235	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
HG267_06250	COG0047	phosphoribosylformylglycinamidine synthase activity
HG267_06255	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HG267_06260	COG0735	belongs to the Fur family
HG267_06270	COG0330	HflC and HflK could
HG267_06315	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
HG267_06320	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
HG267_06335	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
HG267_06370	COG0784	Response regulator, receiver
HG267_06370	COG2205	protein histidine kinase activity
HG267_06380	COG0745	RESPONSE REGULATOR receiver
HG267_06385	COG2198	Histidine kinase
HG267_06385	COG0784	Response regulator, receiver
HG267_06385	COG0643	Histidine kinase
HG267_06405	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HG267_06410	COG2261	transglycosylase associated protein
HG267_06415	COG3237	CsbD-like
HG267_06430	COG4572	Cation transport regulator
HG267_06435	COG0783	Belongs to the Dps family
HG267_06445	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HG267_06465	COG1957	nucleoside hydrolase
HG267_06475	COG1252	NADH dehydrogenase
HG267_06490	COG0174	glutamine synthetase
HG267_06495	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HG267_06515	COG1252	NADH dehydrogenase
HG267_06520	COG2205	protein histidine kinase activity
HG267_06530	COG0277	FAD linked oxidase domain protein
HG267_06535	COG0247	lactate metabolic process
HG267_06550	COG2211	Major facilitator Superfamily
HG267_06555	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
HG267_06610	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
HG267_06640	COG2124	cytochrome p450
HG267_06660	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HG267_06675	COG0667	Aldo Keto reductase
HG267_06690	COG0405	Gamma-glutamyltransferase
HG267_06725	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HG267_06740	COG0739	heme binding
HG267_06795	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
HG267_06835	COG1672	PFAM Archaeal ATPase
HG267_06835	COG2319	Wd-40 repeat
HG267_06840	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
HG267_06845	COG0732	type I restriction modification DNA specificity domain
HG267_06885	COG5635	Nacht domain
HG267_06885	COG2319	Wd-40 repeat
HG267_06885	COG5635	Nacht domain
HG267_06885	COG2319	Wd-40 repeat
HG267_06895	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
HG267_06985	COG1309	transcriptional regulator
HG267_06995	COG2076	Multidrug Resistance protein
HG267_07005	COG0392	lysyltransferase activity
HG267_07005	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
HG267_07015	COG1366	Belongs to the anti-sigma-factor antagonist family
HG267_07020	COG1366	Belongs to the anti-sigma-factor antagonist family
HG267_07035	COG2205	protein histidine kinase activity
HG267_07035	COG2198	Histidine kinase
HG267_07035	COG0784	Response regulator, receiver
HG267_07050	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
HG267_07055	COG0459	protein refolding
HG267_07070	COG1028	Short-chain dehydrogenase reductase Sdr
HG267_07080	COG1012	belongs to the aldehyde dehydrogenase family
HG267_07095	COG2226	methyltransferase
HG267_07100	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
HG267_07100	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HG267_07105	COG3437	response regulator, receiver
HG267_07110	COG2198	Histidine kinase
HG267_07110	COG5002	protein histidine kinase activity
HG267_07110	COG0784	Response regulator, receiver
HG267_07140	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
HG267_07145	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
HG267_07165	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
HG267_07185	COG0424	maF-like protein
HG267_07190	COG1619	proteins homologs of microcin C7 resistance protein MccF
HG267_07210	COG1401	restriction endodeoxyribonuclease activity
HG267_07220	COG2971	BadF BadG BcrA BcrD
HG267_07225	COG2814	Major facilitator Superfamily
HG267_07235	COG0525	valine-tRNA ligase activity
HG267_07245	COG3659	wide pore channel activity
HG267_07250	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
HG267_07290	COG2201	protein-glutamate methylesterase activity
HG267_07310	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HG267_07315	COG2264	protein methyltransferase activity
HG267_07320	COG3118	belongs to the thioredoxin family
HG267_07325	COG0564	pseudouridine synthase activity
HG267_07340	COG0784	Response regulator, receiver
HG267_07360	COG5002	protein histidine kinase activity
HG267_07385	COG0686	Belongs to the AlaDH PNT family
HG267_07400	COG0517	IMP dehydrogenase activity
HG267_07400	COG1125	glycine betaine transport
HG267_07425	COG0668	transmembrane transport
HG267_07435	COG0473	3-isopropylmalate dehydrogenase activity
HG267_07450	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
HG267_07455	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
HG267_07485	COG4636	protein conserved in cyanobacteria
HG267_07510	COG0398	Pfam SNARE associated Golgi protein
HG267_07520	COG0398	Pfam SNARE associated Golgi protein
HG267_07525	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HG267_07590	COG2133	pyrroloquinoline quinone binding
HG267_07615	COG0826	peptidase U32
HG267_07630	COG2261	transglycosylase associated protein
HG267_07640	COG1131	(ABC) transporter
HG267_07650	COG2091	lysine biosynthetic process via aminoadipic acid
HG267_07850	COG2045	Belongs to the ComB family
HG267_07855	COG0438	transferase activity, transferring glycosyl groups
HG267_07860	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
HG267_07925	COG0412	Dienelactone hydrolase
HG267_07930	COG0604	alcohol dehydrogenase
HG267_07945	COG0745	RESPONSE REGULATOR receiver
HG267_07950	COG5002	protein histidine kinase activity
HG267_07960	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
HG267_07985	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HG267_07990	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
HG267_08000	COG0110	maltose O-acetyltransferase activity
HG267_08010	COG0297	glycogen (starch) synthase activity
HG267_08010	COG0438	transferase activity, transferring glycosyl groups
HG267_08020	COG0438	transferase activity, transferring glycosyl groups
HG267_08045	COG0438	transferase activity, transferring glycosyl groups
HG267_08050	COG1215	transferase activity, transferring glycosyl groups
HG267_08060	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HG267_08065	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HG267_08085	COG0673	inositol 2-dehydrogenase activity
HG267_08135	COG0489	protein tyrosine kinase activity
HG267_08170	COG2319	Wd-40 repeat
HG267_08170	COG1672	PFAM Archaeal ATPase
HG267_08200	COG3788	relative of glutathione S-transferase, MAPEG superfamily
HG267_08220	COG0848	biopolymer transport protein
HG267_08225	COG0811	peptide transport
HG267_08270	COG0728	peptidoglycan biosynthetic process
HG267_08275	COG1357	PFAM Pentapeptide repeats (8 copies)
HG267_08280	COG1316	TRANSCRIPTIONal
HG267_08290	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
HG267_08295	COG1129	ABC transporter
HG267_08295	COG0842	Transport permease protein
HG267_08305	COG2326	polyphosphate kinase activity
HG267_08310	COG0463	Glycosyl transferase, family 2
HG267_08325	COG2264	protein methyltransferase activity
HG267_08365	COG2373	Large extracellular alpha-helical protein
HG267_08370	COG4953	penicillin-binding protein 1C
HG267_08455	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
HG267_08470	COG0508	dehydrogenase complex catalyzes the overall conversion of
HG267_08500	COG5002	protein histidine kinase activity
HG267_08505	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HG267_08505	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HG267_08515	COG0509	glycine decarboxylation via glycine cleavage system
HG267_08525	COG0404	The glycine cleavage system catalyzes the degradation of glycine
HG267_08530	COG1357	PFAM Pentapeptide repeats (8 copies)
HG267_08540	COG0776	regulation of translation
HG267_08545	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HG267_08550	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HG267_08560	COG0170	dolichyl monophosphate biosynthetic process
HG267_08565	COG2197	response regulator
HG267_08595	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
HG267_08610	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HG267_08625	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
HG267_08630	COG0793	Belongs to the peptidase S41A family
HG267_08640	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
HG267_08645	COG3751	2OG-Fe(II) oxygenase superfamily
HG267_08655	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
HG267_08660	COG0189	ligase activity
HG267_08665	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
HG267_08680	COG2319	Wd-40 repeat
HG267_08680	COG4249	Peptidase C14 caspase catalytic subunit p20
HG267_08745	COG4447	cellulose binding
HG267_08750	COG1773	rubredoxin
HG267_08755	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HG267_08760	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HG267_08765	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HG267_08825	COG0261	This protein binds to 23S rRNA in the presence of protein L20
HG267_08830	COG0211	Belongs to the bacterial ribosomal protein bL27 family
HG267_08850	COG0328	RNA-DNA hybrid ribonuclease activity
HG267_08895	COG1131	(ABC) transporter
HG267_08915	COG0788	formyltetrahydrofolate deformylase activity
HG267_08920	COG5002	protein histidine kinase activity
HG267_08925	COG4191	Histidine kinase
HG267_08960	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
HG267_08995	COG0484	heat shock protein binding
HG267_09005	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
HG267_09020	COG2205	protein histidine kinase activity
HG267_09025	COG0840	transmembrane signaling receptor activity
HG267_09025	COG2203	Gaf domain
HG267_09040	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
HG267_09055	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HG267_09055	COG0475	glutathione-regulated potassium exporter activity
HG267_09060	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
HG267_09065	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
HG267_09095	COG0752	glycyl-tRNA synthetase alpha subunit
HG267_09105	COG1247	-acetyltransferase
HG267_09115	COG1028	Short-chain dehydrogenase reductase Sdr
HG267_09140	COG1473	amidohydrolase
HG267_09150	COG5592	hemerythrin HHE cation binding domain
HG267_09175	COG0586	Pfam SNARE associated Golgi protein
HG267_09180	COG3932	Exopolysaccharide synthesis, ExoD
HG267_09195	COG2124	cytochrome p450
HG267_09205	COG2208	phosphoserine phosphatase activity
HG267_09205	COG2770	Histidine kinase
HG267_09225	COG1366	Belongs to the anti-sigma-factor antagonist family
HG267_09235	COG3548	integral membrane protein
HG267_09260	COG0822	iron-sulfur transferase activity
HG267_09275	COG3659	wide pore channel activity
HG267_09280	COG3852	Histidine kinase
HG267_09285	COG5000	phosphorelay sensor kinase activity
HG267_09325	COG4221	oxidoreductase activity
HG267_09335	COG1028	Short-chain dehydrogenase reductase Sdr
HG267_09335	COG3321	synthase
HG267_09335	COG0604	alcohol dehydrogenase
HG267_09365	COG0028	Belongs to the TPP enzyme family
HG267_09375	COG2211	Major facilitator Superfamily
HG267_09380	COG3670	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
HG267_09385	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HG267_09400	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HG267_09410	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
HG267_09445	COG3861	electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity
HG267_09470	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HG267_09495	COG2319	Wd-40 repeat
HG267_09495	COG1672	PFAM Archaeal ATPase
HG267_09570	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HG267_09620	COG1006	Multisubunit Na H antiporter MnhC subunit
HG267_09625	COG0651	ATP synthesis coupled electron transport
HG267_09675	COG0222	ribosome binding
HG267_09700	COG1716	ATPase activity
HG267_09705	COG0363	glucosamine-6-phosphate deaminase activity
HG267_09715	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
HG267_09720	COG0563	adenylate kinase activity
HG267_09730	COG0717	Belongs to the dCTP deaminase family
HG267_09735	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
HG267_09740	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
HG267_09760	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
HG267_09765	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HG267_09830	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HG267_09845	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
HG267_09850	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
HG267_09860	COG1285	pathogenesis
HG267_09865	COG0574	Belongs to the PEP-utilizing enzyme family
HG267_09865	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HG267_09905	COG1122	ATPase activity
HG267_09915	COG0310	cobalt ion transport
HG267_09920	COG2132	Multicopper oxidase
HG267_09935	COG0672	)-iron permease
HG267_09945	COG0746	molybdenum cofactor guanylyltransferase activity
HG267_09955	COG1331	Highly conserved protein containing a thioredoxin domain
HG267_09975	COG0740	serine-type endopeptidase activity
HG267_09985	COG0557	exoribonuclease II activity
HG267_09990	COG0163	prenyltransferase activity
HG267_10005	COG2319	Wd-40 repeat
HG267_10005	COG3903	Transcriptional regulator
HG267_10010	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
HG267_10040	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HG267_10045	COG3150	esterase
HG267_10050	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HG267_10065	COG1672	PFAM Archaeal ATPase
HG267_10065	COG2319	Wd-40 repeat
HG267_10085	COG2267	carboxylic ester hydrolase activity
HG267_10095	COG0861	Integral membrane protein TerC family
HG267_10100	COG0105	UTP biosynthetic process
HG267_10105	COG1166	arginine decarboxylase activity
HG267_10110	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
HG267_10120	COG0628	permease
HG267_10125	COG0259	pyridoxamine-phosphate oxidase activity
HG267_10145	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
HG267_10150	COG0683	leucine binding
HG267_10165	COG0668	transmembrane transport
HG267_10180	COG0123	including yeast histone deacetylase and acetoin utilization protein
HG267_10185	COG3266	domain, Protein
HG267_10185	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
HG267_10195	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
HG267_10200	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
HG267_10235	COG0515	serine threonine protein kinase
HG267_10235	COG1357	PFAM Pentapeptide repeats (8 copies)
HG267_10255	COG1846	Transcriptional regulator
HG267_10280	COG0850	regulation of cytokinetic process
HG267_10285	COG2894	cell division
HG267_10290	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
HG267_10315	COG2363	Small membrane protein
HG267_10325	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HG267_10330	COG0589	response to stress
HG267_10330	COG0475	glutathione-regulated potassium exporter activity
HG267_10345	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
HG267_10350	COG0004	ammonium transporteR
HG267_10355	COG1742	UPF0060 membrane protein
HG267_10360	COG0004	ammonium transporteR
HG267_10375	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HG267_10405	COG3854	ATPases associated with a variety of cellular activities
HG267_10420	COG2197	response regulator
HG267_10450	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
HG267_10460	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HG267_10470	COG2197	response regulator
HG267_10480	COG0435	Glutathione S-transferase
HG267_10495	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HG267_10505	COG2814	Major facilitator Superfamily
HG267_10520	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HG267_10605	COG0107	imidazoleglycerol-phosphate synthase activity
HG267_10610	COG2255	four-way junction helicase activity
HG267_10630	COG0574	Belongs to the PEP-utilizing enzyme family
HG267_10630	COG3848	Pyruvate phosphate dikinase
HG267_10655	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
HG267_10660	COG0009	L-threonylcarbamoyladenylate synthase
HG267_10690	COG0438	transferase activity, transferring glycosyl groups
HG267_10695	COG0010	Belongs to the arginase family
HG267_10710	COG0793	Belongs to the peptidase S41A family
HG267_10710	COG3409	Peptidoglycan-binding domain 1 protein
HG267_10715	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HG267_10745	COG0784	Response regulator, receiver
HG267_10745	COG2205	protein histidine kinase activity
HG267_10760	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
HG267_10775	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
HG267_10780	COG2226	methyltransferase
HG267_10790	COG1546	Belongs to the CinA family
HG267_10790	COG1058	Belongs to the CinA family
HG267_10795	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HG267_10800	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
HG267_10815	COG0179	Fumarylacetoacetate (FAA) hydrolase
HG267_10820	COG0360	Binds together with S18 to 16S ribosomal RNA
HG267_10835	COG0586	Pfam SNARE associated Golgi protein
HG267_10840	COG0137	argininosuccinate synthase activity
HG267_10850	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
HG267_10875	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
HG267_10890	COG0616	signal peptide processing
HG267_10935	COG1994	Peptidase M50
HG267_10935	COG0517	IMP dehydrogenase activity
HG267_10945	COG0135	phosphoribosylanthranilate isomerase activity
HG267_10950	COG0302	gtp cyclohydrolase
HG267_10955	COG0300	oxidoreductase activity
HG267_10960	COG0825	malonyl-CoA metabolic process
HG267_10965	COG5322	oxidoreductase activity
HG267_10970	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
HG267_10975	COG0395	ABC-type sugar transport system, permease component
HG267_11000	COG0515	serine threonine protein kinase
HG267_11010	COG0631	protein serine/threonine phosphatase activity
HG267_11015	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
HG267_11020	COG3937	granule-associated protein
HG267_11025	COG0488	(ABC) transporter
HG267_11040	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
HG267_11050	COG1733	regulation of RNA biosynthetic process
HG267_11065	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
HG267_11070	COG1215	transferase activity, transferring glycosyl groups
HG267_11080	COG0857	belongs to the CobB CobQ family
HG267_11090	COG1666	GTP binding
HG267_11125	COG1070	Carbohydrate kinase
HG267_11130	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
HG267_11180	COG0159	tryptophan synthase activity
HG267_11200	COG0784	Response regulator, receiver
HG267_11205	COG3437	response regulator, receiver
HG267_11205	COG4999	Histidine kinase
HG267_11205	COG2205	protein histidine kinase activity
HG267_11205	COG3850	Histidine kinase
HG267_11210	COG2205	protein histidine kinase activity
HG267_11210	COG3437	response regulator, receiver
HG267_11210	COG4999	Histidine kinase
HG267_11210	COG3850	Histidine kinase
HG267_11215	COG0784	Response regulator, receiver
HG267_11220	COG4251	negative regulation of phosphorylation
HG267_11225	COG2197	response regulator
HG267_11235	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HG267_11245	COG0515	serine threonine protein kinase
HG267_11245	COG2815	serine threonine protein kinase
HG267_11255	COG3842	ATPase activity
HG267_11275	COG0629	single-stranded DNA binding
HG267_11280	COG4172	Belongs to the ABC transporter superfamily
HG267_11315	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
HG267_11325	COG1215	transferase activity, transferring glycosyl groups
HG267_11340	COG3659	wide pore channel activity
HG267_11345	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HG267_11350	COG0704	Plays a role in the regulation of phosphate uptake
HG267_11355	COG5002	protein histidine kinase activity
HG267_11360	COG0745	RESPONSE REGULATOR receiver
HG267_11375	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
HG267_11400	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HG267_11405	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HG267_11435	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HG267_11435	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HG267_11440	COG0561	phosphatase activity
HG267_11445	COG0018	arginyl-trna synthetase
HG267_11450	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HG267_11455	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
HG267_11465	COG0515	serine threonine protein kinase
HG267_11470	COG0583	DNA-binding transcription factor activity
HG267_11480	COG3118	belongs to the thioredoxin family
HG267_11485	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HG267_11490	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HG267_11505	COG0515	serine threonine protein kinase
HG267_11505	COG3266	domain, Protein
HG267_11510	COG0681	Belongs to the peptidase S26 family
HG267_11515	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HG267_11530	COG5002	protein histidine kinase activity
HG267_11530	COG0784	Response regulator, receiver
HG267_11535	COG0814	amino acid
HG267_11540	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HG267_11550	COG0745	RESPONSE REGULATOR receiver
HG267_11560	COG1252	NADH dehydrogenase
HG267_11575	COG1309	transcriptional regulator
HG267_11580	COG0584	glycerophosphoryl diester phosphodiesterase
HG267_11610	COG0351	phosphomethylpyrimidine kinase
HG267_11625	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
HG267_11630	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HG267_11645	COG0586	Pfam SNARE associated Golgi protein
HG267_11650	COG0673	inositol 2-dehydrogenase activity
HG267_11655	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
HG267_11660	COG1253	flavin adenine dinucleotide binding
HG267_11680	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
HG267_11690	COG2161	toxin-antitoxin pair type II binding
HG267_11695	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
HG267_11700	COG1187	pseudouridine synthase activity
HG267_11705	COG5002	protein histidine kinase activity
HG267_11715	COG0515	serine threonine protein kinase
HG267_11715	COG1357	PFAM Pentapeptide repeats (8 copies)
HG267_11735	COG0028	Belongs to the TPP enzyme family
HG267_11735	COG4032	Thiamine pyrophosphate enzyme, N-terminal TPP binding domain
HG267_11750	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
HG267_11765	COG4968	Prepilin-type N-terminal cleavage methylation domain
HG267_11775	COG0492	ferredoxin-NADP+ reductase activity
HG267_11780	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HG267_11790	COG1940	carbohydrate kinase activity
HG267_11800	COG0504	CTP synthase activity
HG267_11835	COG1834	amidinotransferase
HG267_11850	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
HG267_11855	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HG267_11860	COG0475	glutathione-regulated potassium exporter activity
HG267_11860	COG0589	response to stress
HG267_11875	COG0772	Belongs to the SEDS family
HG267_11880	COG0489	protein tyrosine kinase activity
HG267_11890	COG0408	coproporphyrinogen oxidase activity
HG267_11915	COG0848	biopolymer transport protein
HG267_11920	COG0811	peptide transport
HG267_11965	COG0824	Thioesterase
HG267_11970	COG0318	PFAM AMP-dependent synthetase and ligase
HG267_11980	COG1575	Belongs to the MenA family. Type 1 subfamily
HG267_11995	COG0628	permease
HG267_12000	COG0318	PFAM AMP-dependent synthetase and ligase
HG267_12000	COG0204	Acyl-transferase
HG267_12005	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
HG267_12010	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HG267_12015	COG0416	fatty acid biosynthetic process
HG267_12020	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
HG267_12050	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HG267_12080	COG3118	belongs to the thioredoxin family
HG267_12085	COG0516	GMP reductase activity
HG267_12090	COG1193	negative regulation of DNA recombination
HG267_12135	COG4948	Mandelate Racemase Muconate Lactonizing
HG267_12165	COG1028	Short-chain dehydrogenase reductase Sdr
HG267_12185	COG0589	response to stress
HG267_12195	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HG267_12200	COG2814	Major facilitator Superfamily
HG267_12220	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
HG267_12230	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
HG267_12240	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
HG267_12245	COG5002	protein histidine kinase activity
HG267_12245	COG5001	Diguanylate cyclase
HG267_12245	COG3447	MASE1 domain protein
HG267_12250	COG0110	maltose O-acetyltransferase activity
HG267_12255	COG1361	Conserved repeat domain
HG267_12265	COG0489	protein tyrosine kinase activity
HG267_12280	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
HG267_12285	COG0297	glycogen (starch) synthase activity
HG267_12285	COG0438	transferase activity, transferring glycosyl groups
HG267_12305	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HG267_12310	COG2081	HI0933 family
HG267_12315	COG1773	rubredoxin
HG267_12340	COG0542	response to heat
HG267_12360	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
HG267_12370	COG1850	ribulose-bisphosphate carboxylase activity
HG267_12380	COG4451	ribulose bisphosphate carboxylase, small
HG267_12410	COG1429	ligase activity, forming nitrogen-metal bonds
HG267_12465	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
HG267_12470	COG0497	DNA recombination
HG267_12475	COG0542	response to heat
HG267_12490	COG0469	pyruvate kinase activity
HG267_12505	COG0438	transferase activity, transferring glycosyl groups
HG267_12530	COG0438	transferase activity, transferring glycosyl groups
HG267_12540	COG2226	methyltransferase
HG267_12565	COG0003	Pfam Anion-transporting ATPase
HG267_12570	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
HG267_12585	COG2124	cytochrome p450
HG267_12605	COG0297	glycogen (starch) synthase activity
HG267_12620	COG1357	PFAM Pentapeptide repeats (8 copies)
HG267_12620	COG0515	serine threonine protein kinase
HG267_12630	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HG267_12635	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HG267_12655	COG2166	iron-sulfur cluster assembly
HG267_12690	COG0523	cobalamin synthesis protein
HG267_12715	COG1132	(ABC) transporter
HG267_12735	COG2205	protein histidine kinase activity
HG267_12740	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
HG267_12740	COG0784	Response regulator, receiver
HG267_12820	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HG267_12845	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
HG267_12850	COG0667	Aldo Keto reductase
HG267_12855	COG3659	wide pore channel activity
HG267_12860	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HG267_12865	COG0778	Nitroreductase
HG267_12870	COG1116	anion transmembrane transporter activity
HG267_12875	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HG267_12880	COG2175	clavaminate synthase activity
HG267_12885	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HG267_12890	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HG267_12905	COG2856	Zn peptidase
HG267_13095	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
HG267_13100	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HG267_13150	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
HG267_13155	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HG267_13250	COG0723	plastoquinol--plastocyanin reductase activity
HG267_13270	COG2226	methyltransferase
HG267_13280	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
HG267_13285	COG1899	peptidyl-lysine modification to peptidyl-hypusine
HG267_13290	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HG267_13320	COG1595	DNA-templated transcription, initiation
HG267_13355	COG3621	Patatin-like phospholipase
HG267_13370	COG3706	GGDEF domain
HG267_13380	COG5001	Diguanylate cyclase
HG267_13380	COG3706	GGDEF domain
HG267_13380	COG4251	negative regulation of phosphorylation
HG267_13380	COG2203	Gaf domain
HG267_13390	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
HG267_13575	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HG267_13690	COG0546	phosphoglycolate phosphatase activity
HG267_13695	COG2226	methyltransferase
HG267_13720	COG0385	Bile acid
HG267_13725	COG0667	Aldo Keto reductase
HG267_13730	COG1899	peptidyl-lysine modification to peptidyl-hypusine
HG267_13760	COG0546	phosphoglycolate phosphatase activity
HG267_13765	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
HG267_13770	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
HG267_13785	COG0346	lactoylglutathione lyase activity
HG267_13790	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
HG267_13815	COG1073	alpha beta
HG267_13820	COG0154	amidase activity
HG267_13825	COG0587	DNA-directed DNA polymerase activity
HG267_13845	COG0310	cobalt ion transport
HG267_13850	COG1930	Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import
HG267_13860	COG1122	ATPase activity
HG267_13880	COG0484	heat shock protein binding
HG267_13900	COG0243	molybdopterin cofactor binding
HG267_13905	COG2223	nitrite transmembrane transporter activity
HG267_13910	COG1116	anion transmembrane transporter activity
HG267_13915	COG1116	anion transmembrane transporter activity
HG267_13915	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HG267_13920	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HG267_13925	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HG267_13985	COG1214	PFAM Peptidase M22, glycoprotease
HG267_13995	COG0617	tRNA 3'-terminal CCA addition
HG267_14005	COG0515	serine threonine protein kinase
HG267_14010	COG0515	serine threonine protein kinase
HG267_14025	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HG267_14035	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HG267_14045	COG4680	protein conserved in bacteria
HG267_14050	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
HG267_14080	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HG267_14085	COG0678	peroxiredoxin activity
HG267_14095	COG1357	PFAM Pentapeptide repeats (8 copies)
HG267_14100	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
HG267_14110	COG0612	Peptidase, M16
HG267_14120	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HG267_14120	COG0072	phenylalanine-tRNA ligase activity
HG267_14145	COG4251	negative regulation of phosphorylation
HG267_14150	COG0784	Response regulator, receiver
HG267_14160	COG0519	Catalyzes the synthesis of GMP from XMP
HG267_14175	COG1132	(ABC) transporter
HG267_14215	COG2321	neutral zinc metallopeptidase
HG267_14230	COG0668	transmembrane transport
HG267_14240	COG0419	ATPase involved in DNA repair
HG267_14250	COG1361	Conserved repeat domain
HG267_14255	COG2205	protein histidine kinase activity
HG267_14290	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
HG267_14295	COG0750	zinc metalloprotease
HG267_14300	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
HG267_14305	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
HG267_14315	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
HG267_14355	COG0456	acetyltransferase
HG267_14360	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
HG267_14360	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
HG267_14395	COG0515	serine threonine protein kinase
HG267_14395	COG1357	PFAM Pentapeptide repeats (8 copies)
HG267_14405	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HG267_14420	COG0793	Belongs to the peptidase S41A family
HG267_14425	COG1215	transferase activity, transferring glycosyl groups
HG267_14490	COG1473	amidohydrolase
HG267_14495	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
HG267_14500	COG0515	serine threonine protein kinase
HG267_14500	COG3266	domain, Protein
HG267_14505	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HG267_14530	COG1217	gtp-binding protein TYPA
HG267_14560	COG0346	lactoylglutathione lyase activity
HG267_14565	COG0542	response to heat
HG267_14570	COG0515	serine threonine protein kinase
HG267_14570	COG1357	PFAM Pentapeptide repeats (8 copies)
HG267_14580	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
HG267_14590	COG0393	Putative heavy-metal-binding
HG267_14610	COG4279	zinc finger
HG267_14625	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HG267_14625	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HG267_14635	COG1185	polyribonucleotide nucleotidyltransferase activity
HG267_14655	COG4372	Transposase
HG267_14660	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HG267_14665	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
HG267_14675	COG0131	Imidazoleglycerol-phosphate dehydratase
HG267_14685	COG1131	(ABC) transporter
HG267_14690	COG1596	polysaccharide export
HG267_14700	COG0330	HflC and HflK could
HG267_14705	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
HG267_14710	COG0149	triose-phosphate isomerase activity
HG267_14720	COG1160	GTP binding
HG267_14740	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
HG267_14765	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HG267_14770	COG5398	heme oxygenase
HG267_14815	COG0628	permease
HG267_14820	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
HG267_14820	COG0284	orotidine-5'-phosphate decarboxylase activity
HG267_14825	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
HG267_14835	COG5002	protein histidine kinase activity
HG267_14835	COG0784	Response regulator, receiver
HG267_14835	COG2205	protein histidine kinase activity
HG267_14845	COG0745	RESPONSE REGULATOR receiver
HG267_14865	COG0436	Aminotransferase
HG267_14890	COG1598	PFAM Uncharacterised protein family UPF0150
HG267_14900	COG0484	heat shock protein binding
HG267_14905	COG0443	Heat shock 70 kDa protein
HG267_14910	COG2234	aminopeptidase activity
HG267_14915	COG3781	membrane
HG267_14940	COG3266	domain, Protein
HG267_14940	COG0515	serine threonine protein kinase
HG267_14950	COG0515	serine threonine protein kinase
HG267_14965	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HG267_14995	COG3903	Transcriptional regulator
HG267_14995	COG2319	Wd-40 repeat
HG267_15010	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
HG267_15035	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
HG267_15040	COG0291	Belongs to the bacterial ribosomal protein bL35 family
HG267_15055	COG0121	glutamine amidotransferase
HG267_15070	COG0312	modulator of DNA gyrase
HG267_15080	COG0312	modulator of DNA gyrase
HG267_15090	COG1032	radical SAM domain protein
HG267_15125	COG5002	protein histidine kinase activity
HG267_15130	COG0840	transmembrane signaling receptor activity
HG267_15130	COG2203	Gaf domain
HG267_15185	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
HG267_15190	COG1104	cysteine desulfurase activity
HG267_15225	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
HG267_15250	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
HG267_15255	COG0066	3-isopropylmalate dehydratase activity
HG267_15260	COG2003	Belongs to the UPF0758 family
HG267_15275	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HG267_15325	COG2815	serine threonine protein kinase
HG267_15325	COG0515	serine threonine protein kinase
HG267_15330	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
HG267_15330	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
HG267_15345	COG2119	membrane
HG267_15355	COG0745	RESPONSE REGULATOR receiver
HG267_15360	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
HG267_15365	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
HG267_15380	COG2815	serine threonine protein kinase
HG267_15380	COG0515	serine threonine protein kinase
HG267_15385	COG3903	Transcriptional regulator
HG267_15385	COG2319	Wd-40 repeat
HG267_15390	COG0765	amino acid transport
HG267_15395	COG1126	abc transporter atp-binding protein
HG267_15415	COG0321	lipoyl(octanoyl) transferase activity
HG267_15420	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
HG267_15425	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HG267_15510	COG0230	Belongs to the bacterial ribosomal protein bL34 family
HG267_15515	COG0594	ribonuclease P activity
HG267_15525	COG0706	membrane insertase activity
HG267_15540	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HG267_15560	COG2912	Transglutaminase-like superfamily
HG267_15565	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
HG267_15570	COG0355	proton-transporting ATP synthase activity, rotational mechanism
HG267_15620	COG1606	tRNA processing
HG267_15635	COG3958	Transketolase
HG267_15650	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
HG267_15650	COG0456	acetyltransferase
HG267_15655	COG0671	phosphoesterase, PA-phosphatase related
HG267_15680	COG0724	RNA recognition motif
HG267_15720	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HG267_15725	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HG267_15730	COG2319	Wd-40 repeat
HG267_15730	COG1672	PFAM Archaeal ATPase
HG267_15745	COG1385	rRNA (uridine-N3-)-methyltransferase activity
HG267_15760	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
HG267_15770	COG1836	PFAM Integral membrane protein DUF92
HG267_15805	COG0656	L-ascorbic acid biosynthetic process
HG267_15815	COG0501	Belongs to the peptidase M48B family
HG267_15845	COG0824	Thioesterase
HG267_15875	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HG267_15925	COG1028	Short-chain dehydrogenase reductase Sdr
HG267_15940	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
HG267_15955	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
HG267_15965	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HG267_15975	COG0406	alpha-ribazole phosphatase activity
HG267_15980	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HG267_15985	COG4999	Histidine kinase
HG267_15985	COG3850	Histidine kinase
HG267_15985	COG2205	protein histidine kinase activity
HG267_15985	COG3437	response regulator, receiver
HG267_16000	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
HG267_16005	COG0745	RESPONSE REGULATOR receiver
HG267_16010	COG2815	serine threonine protein kinase
HG267_16010	COG0515	serine threonine protein kinase
HG267_16015	COG1028	Short-chain dehydrogenase reductase Sdr
HG267_16025	COG2072	flavoprotein involved in K transport
HG267_16045	COG0784	Response regulator, receiver
HG267_16045	COG2198	Histidine kinase
HG267_16045	COG2205	protein histidine kinase activity
HG267_16055	COG1007	ATP synthesis coupled electron transport
HG267_16070	COG0395	ABC-type sugar transport system, permease component
HG267_16085	COG2010	Cytochrome c
HG267_16090	COG2010	Cytochrome c
HG267_16095	COG3794	PFAM blue (type 1) copper domain protein
HG267_16115	COG4636	protein conserved in cyanobacteria
HG267_16120	COG0517	IMP dehydrogenase activity
HG267_16120	COG0617	tRNA 3'-terminal CCA addition
HG267_16120	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
HG267_16130	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
HG267_16145	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
HG267_16150	COG3239	Fatty acid desaturase
HG267_16155	COG3239	Fatty acid desaturase
HG267_16160	COG3239	Fatty acid desaturase
HG267_16170	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
HG267_16175	COG1035	Coenzyme F420 hydrogenase/dehydrogenase, beta subunit C terminus
HG267_16180	COG0484	heat shock protein binding
HG267_16185	COG4232	protein-disulfide reductase activity
HG267_16190	COG1333	cytochrome c biogenesis protein
HG267_16200	COG1022	Amp-dependent synthetase and ligase
HG267_16215	COG0514	ATP-dependent DNA helicase (RecQ)
HG267_16220	COG0430	RNA-3'-phosphate cyclase activity
HG267_16245	COG2852	Protein conserved in bacteria
HG267_16275	COG0401	homolog of Blt101
HG267_16280	COG0023	Translation Initiation Factor
HG267_16285	COG0133	tryptophan synthase activity
HG267_16295	COG0494	nUDIX hydrolase
HG267_16300	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
HG267_16305	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
HG267_16320	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
HG267_16320	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HG267_16340	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
HG267_16345	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
HG267_16345	COG0674	pyruvate-flavodoxin oxidoreductase activity
HG267_16345	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
HG267_16345	COG1013	pyruvate-flavodoxin oxidoreductase activity
HG267_16355	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HG267_16360	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HG267_16365	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
HG267_16370	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
HG267_16375	COG4576	ethanolamine utilization protein EutN carboxysome structural protein Ccml
HG267_16380	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
HG267_16380	COG4451	ribulose bisphosphate carboxylase, small
HG267_16385	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
HG267_16390	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
HG267_16395	COG0583	DNA-binding transcription factor activity
HG267_16415	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
HG267_16440	COG0438	transferase activity, transferring glycosyl groups
HG267_16445	COG2244	polysaccharide biosynthetic process
HG267_16460	COG0438	transferase activity, transferring glycosyl groups
HG267_16465	COG0438	transferase activity, transferring glycosyl groups
HG267_16495	COG2267	carboxylic ester hydrolase activity
HG267_16515	COG0693	protein deglycase activity
HG267_16565	COG1136	(ABC) transporter
HG267_16580	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HG267_16605	COG3850	Histidine kinase
HG267_16605	COG3437	response regulator, receiver
HG267_16605	COG4999	Histidine kinase
HG267_16605	COG2205	protein histidine kinase activity
HG267_16620	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HG267_16620	COG2205	protein histidine kinase activity
HG267_16635	COG0562	UDP-galactopyranose mutase
HG267_16660	COG0450	alkyl hydroperoxide reductase
HG267_16670	COG0024	Methionine aminopeptidase
HG267_16680	COG0612	Peptidase, M16
HG267_16705	COG0285	dihydrofolate synthase activity
HG267_16715	COG4802	Ferredoxin thioredoxin reductase catalytic beta chain
HG267_16735	COG0148	phosphopyruvate hydratase activity
HG267_16740	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
HG267_16745	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HG267_16745	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HG267_16755	COG1262	PFAM Formylglycine-generating sulfatase enzyme
HG267_16805	COG0170	dolichyl monophosphate biosynthetic process
HG267_16810	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
HG267_16815	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
HG267_16835	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
HG267_16840	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
HG267_16850	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
HG267_16925	COG2217	Heavy metal translocating P-type atpase
HG267_16940	COG1090	epimerase
HG267_16955	COG0316	Belongs to the HesB IscA family
HG267_16970	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
HG267_16995	COG1492	cobalamin metabolic process
HG267_17005	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HG267_17025	COG1404	Belongs to the peptidase S8 family
HG267_17035	COG0542	response to heat
HG267_17055	COG0515	serine threonine protein kinase
HG267_17075	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
HG267_17080	COG0408	coproporphyrinogen oxidase activity
HG267_17085	COG5398	heme oxygenase
HG267_17135	COG0438	transferase activity, transferring glycosyl groups
HG267_17140	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HG267_17145	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
HG267_17150	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HG267_17155	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
HG267_17175	COG1132	(ABC) transporter
HG267_17185	COG2226	methyltransferase
HG267_17190	COG0438	transferase activity, transferring glycosyl groups
HG267_17200	COG1216	Glycosyl transferase, family 2
HG267_17210	COG1234	tRNA 3'-trailer cleavage
HG267_17240	COG1357	PFAM Pentapeptide repeats (8 copies)
HG267_17240	COG0515	serine threonine protein kinase
HG267_17250	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
HG267_17285	COG2205	protein histidine kinase activity
HG267_17285	COG0784	Response regulator, receiver
HG267_17290	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
HG267_17295	COG0572	uridine kinase
HG267_17305	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
HG267_17310	COG0460	homoserine dehydrogenase
HG267_17320	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
HG267_17340	COG3842	ATPase activity
HG267_17345	COG0515	serine threonine protein kinase
HG267_17350	COG0538	isocitrate dehydrogenase activity
HG267_17365	COG0515	serine threonine protein kinase
HG267_17365	COG2815	serine threonine protein kinase
HG267_17370	COG0515	serine threonine protein kinase
HG267_17370	COG2815	serine threonine protein kinase
HG267_17375	COG0515	serine threonine protein kinase
HG267_17375	COG2815	serine threonine protein kinase
HG267_17380	COG0515	serine threonine protein kinase
HG267_17380	COG2815	serine threonine protein kinase
HG267_17385	COG2815	serine threonine protein kinase
HG267_17385	COG0515	serine threonine protein kinase
HG267_17400	COG0784	Response regulator, receiver
HG267_17400	COG2205	protein histidine kinase activity
HG267_17400	COG2198	Histidine kinase
HG267_17410	COG2815	serine threonine protein kinase
HG267_17410	COG0515	serine threonine protein kinase
HG267_17425	COG0357	Ribosomal RNA small subunit methyltransferase G
HG267_17430	COG1122	ATPase activity
HG267_17475	COG0300	oxidoreductase activity
HG267_17480	COG4680	protein conserved in bacteria
HG267_17490	COG5002	protein histidine kinase activity
HG267_17495	COG2203	Gaf domain
HG267_17495	COG3706	GGDEF domain
HG267_17495	COG5001	Diguanylate cyclase
HG267_17495	COG4251	negative regulation of phosphorylation
HG267_17500	COG5002	protein histidine kinase activity
HG267_17505	COG0784	Response regulator, receiver
HG267_17510	COG4251	negative regulation of phosphorylation
HG267_17525	COG0574	Belongs to the PEP-utilizing enzyme family
HG267_17525	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HG267_17550	COG2326	polyphosphate kinase activity
HG267_17565	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HG267_17575	COG1131	(ABC) transporter
HG267_17580	COG0842	Transport permease protein
HG267_17580	COG1129	ABC transporter
HG267_17590	COG0842	Transport permease protein
HG267_17595	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
HG267_17605	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
HG267_17610	COG0052	Belongs to the universal ribosomal protein uS2 family
HG267_17640	COG0702	epimerase
HG267_17655	COG0666	response to abiotic stimulus
HG267_17670	COG1950	PFAM Membrane protein of
HG267_17685	COG1797	cobyrinic acid a,c-diamide synthase activity
HG267_17700	COG1615	UPF0182 protein
HG267_17710	COG1420	regulation of RNA biosynthetic process
HG267_17730	COG0590	tRNA wobble adenosine to inosine editing
HG267_17745	COG1404	Belongs to the peptidase S8 family
HG267_17745	COG4935	Belongs to the peptidase S8 family
HG267_17755	COG0271	Belongs to the BolA IbaG family
HG267_17760	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
HG267_17765	COG0402	S-adenosylhomocysteine deaminase activity
HG267_17800	COG3266	domain, Protein
HG267_17800	COG0515	serine threonine protein kinase
HG267_17810	COG1672	PFAM Archaeal ATPase
HG267_17810	COG2319	Wd-40 repeat
HG267_17825	COG5002	protein histidine kinase activity
HG267_17875	COG2197	response regulator
HG267_17880	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HG267_17890	COG2203	Gaf domain
HG267_17890	COG0840	transmembrane signaling receptor activity
HG267_17895	COG3063	Type IV pilus biogenesis stability protein PilW
HG267_17910	COG2831	hemolysin activation secretion protein
HG267_17995	COG4106	trans-aconitate 2-methyltransferase activity
HG267_18010	COG1160	GTP binding
HG267_18020	COG1304	FMN binding
HG267_18025	COG0616	signal peptide processing
HG267_18060	COG2201	protein-glutamate methylesterase activity
HG267_18065	COG1215	transferase activity, transferring glycosyl groups
HG267_18080	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
HG267_18095	COG0446	pyridine nucleotide-disulphide oxidoreductase
HG267_18105	COG0640	Transcriptional regulator
HG267_18115	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HG267_18120	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HG267_18135	COG1845	cytochrome c oxidase, subunit III
HG267_18155	COG0668	transmembrane transport
HG267_18185	COG0745	RESPONSE REGULATOR receiver
HG267_18220	COG1361	Conserved repeat domain
HG267_18245	COG2205	protein histidine kinase activity
HG267_18250	COG0768	penicillin binding
HG267_18255	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HG267_18270	COG0438	transferase activity, transferring glycosyl groups
HG267_18280	COG0438	transferase activity, transferring glycosyl groups
HG267_18370	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
HG267_18380	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
HG267_18470	COG1012	belongs to the aldehyde dehydrogenase family
HG267_18480	COG1216	Glycosyl transferase, family 2
HG267_18500	COG4636	protein conserved in cyanobacteria
HG267_18505	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
HG267_18505	COG0140	phosphoribosyl-ATP diphosphatase activity
HG267_18515	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
HG267_18520	COG0596	Alpha beta hydrolase
HG267_18525	COG1937	Protein conserved in bacteria
HG267_18535	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HG267_18555	COG1136	(ABC) transporter
HG267_18555	COG0577	efflux transmembrane transporter activity
HG267_18560	COG1136	(ABC) transporter
HG267_18575	COG0577	efflux transmembrane transporter activity
HG267_18575	COG1136	(ABC) transporter
HG267_18580	COG0583	DNA-binding transcription factor activity
HG267_18585	COG0129	dihydroxy-acid dehydratase activity
HG267_18595	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
HG267_18600	COG3659	wide pore channel activity
HG267_18620	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
HG267_18625	COG2203	Gaf domain
HG267_18645	COG2084	Dehydrogenase
HG267_18695	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HG267_18700	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
HG267_18705	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HG267_18710	COG0187	DNA topoisomerase II activity
HG267_18710	COG1372	Participates in initiation and elongation during chromosome replication
HG267_18715	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
HG267_18730	COG0277	FAD linked oxidase domain protein
HG267_18750	COG4251	negative regulation of phosphorylation
HG267_18750	COG2203	Gaf domain
HG267_18750	COG3706	GGDEF domain
HG267_18750	COG5001	Diguanylate cyclase
HG267_18775	COG0837	glucose binding
HG267_18825	COG0463	Glycosyl transferase, family 2
HG267_18830	COG0398	Pfam SNARE associated Golgi protein
HG267_18845	COG0233	cytoplasmic translational termination
HG267_18850	COG0528	UMP kinase activity
HG267_18870	COG0646	methionine synthase
HG267_18870	COG1410	methionine synthase
HG267_18875	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
HG267_18880	COG0391	Required for morphogenesis under gluconeogenic growth conditions
HG267_18885	COG0802	atpase or kinase
HG267_18890	COG0768	penicillin binding
HG267_18910	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
HG267_18915	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HG267_18920	COG4689	acetoacetate decarboxylase
HG267_18925	COG0443	Heat shock 70 kDa protein
HG267_18965	COG0513	Belongs to the DEAD box helicase family
HG267_18970	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HG267_18975	COG0434	BtpA family
HG267_18980	COG4243	Vitamin k epoxide reductase
HG267_19000	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
HG267_19010	COG0515	serine threonine protein kinase
HG267_19030	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
HG267_19035	COG1555	photosystem II stabilization
HG267_19040	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
HG267_19050	COG0644	oxidoreductase
HG267_19055	COG1982	Orn Lys Arg decarboxylase major
HG267_19065	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HG267_19070	COG3852	Histidine kinase
HG267_19100	COG2124	cytochrome p450
HG267_19105	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
HG267_19110	COG0436	Aminotransferase
HG267_19125	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HG267_19150	COG1635	Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur
HG267_19180	COG0426	domain, Protein
HG267_19180	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HG267_19195	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HG267_19195	COG0426	domain, Protein
HG267_19210	COG1773	rubredoxin
HG267_19220	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HG267_19225	COG0583	DNA-binding transcription factor activity
HG267_19235	COG1181	Belongs to the D-alanine--D-alanine ligase family
HG267_19245	COG0438	transferase activity, transferring glycosyl groups
HG267_19285	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
HG267_19290	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
HG267_19295	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
HG267_19305	COG0037	tRNA processing
HG267_19340	COG0643	Histidine kinase
HG267_19340	COG2198	Histidine kinase
HG267_19340	COG0643	Histidine kinase
HG267_19340	COG0784	Response regulator, receiver
HG267_19340	COG0784	Response regulator, receiver
HG267_19340	COG2198	Histidine kinase
HG267_19345	COG1505	serine-type exopeptidase activity
HG267_19370	COG0612	Peptidase, M16
HG267_19380	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
HG267_19390	COG1981	membrane
HG267_19400	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HG267_19400	COG2022	thiamine diphosphate biosynthetic process
HG267_19430	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
HG267_19435	COG3977	Valine--pyruvate aminotransferase
HG267_19440	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
HG267_19450	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
HG267_19460	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HG267_19470	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HG267_19495	COG2329	Antibiotic biosynthesis monooxygenase
HG267_19500	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HG267_19515	COG5002	protein histidine kinase activity
HG267_19550	COG1054	Belongs to the UPF0176 family
HG267_19570	COG0572	uridine kinase
HG267_19580	COG4399	Belongs to the UPF0754 family
HG267_19585	COG2226	methyltransferase
HG267_19590	COG2204	response regulator
HG267_19605	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HG267_19610	COG0581	inorganic phosphate transmembrane transporter activity
HG267_19615	COG0573	inorganic phosphate transmembrane transporter activity
HG267_19620	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
HG267_19625	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HG267_19645	COG0745	RESPONSE REGULATOR receiver
HG267_19660	COG2814	Major facilitator Superfamily
HG267_19670	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
HG267_19680	COG0275	rRNA processing
HG267_19740	COG0649	NAD binding
HG267_19755	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
HG267_19760	COG1480	7TM receptor with intracellular HD hydrolase
HG267_19770	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
HG267_19775	COG1754	DNA topoisomerase type I activity
HG267_19775	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HG267_19790	COG0724	RNA recognition motif
HG267_19795	COG2843	Capsule synthesis protein
HG267_19845	COG0758	DNA mediated transformation
HG267_19845	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HG267_19925	COG0725	ABC transporter, periplasmic molybdate-binding protein
HG267_19930	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
HG267_19950	COG0725	ABC transporter, periplasmic molybdate-binding protein
HG267_19955	COG3659	wide pore channel activity
HG267_19965	COG4636	protein conserved in cyanobacteria
HG267_19990	COG0739	heme binding
HG267_19990	COG1196	nuclear chromosome segregation
HG267_19990	COG0741	lytic transglycosylase activity
HG267_20000	COG1496	oxidoreductase activity
HG267_20025	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HG267_20035	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HG267_20085	COG1619	proteins homologs of microcin C7 resistance protein MccF
HG267_20090	COG4310	Domain of unknown function (DUF2172)
HG267_20095	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
HG267_20110	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
HG267_20130	COG0495	leucyl-tRNA aminoacylation
HG267_20145	COG1595	DNA-templated transcription, initiation
HG267_20150	COG1376	ErfK ybiS ycfS ynhG family protein
HG267_20160	COG0739	heme binding
HG267_20170	COG1136	(ABC) transporter
HG267_20170	COG0577	efflux transmembrane transporter activity
HG267_20220	COG0438	transferase activity, transferring glycosyl groups
HG267_20240	COG0463	Glycosyl transferase, family 2
HG267_20240	COG1216	Glycosyl transferase, family 2
HG267_20245	COG1132	(ABC) transporter
HG267_20255	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HG267_20260	COG0489	protein tyrosine kinase activity
HG267_20285	COG1216	Glycosyl transferase, family 2
HG267_20290	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HG267_20300	COG0579	oxidoreductase
HG267_20305	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
HG267_20320	COG4245	von Willebrand factor, type A
HG267_20340	COG3631	Ketosteroid isomerase-related protein
HG267_20350	COG0446	pyridine nucleotide-disulphide oxidoreductase
HG267_20355	COG0166	Belongs to the GPI family
HG267_20380	COG0640	Transcriptional regulator
HG267_20390	COG4636	protein conserved in cyanobacteria
HG267_20400	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
HG267_20405	COG1494	fructose-1,6-bisphosphatase
HG267_20415	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
HG267_20425	COG1045	serine acetyltransferase
HG267_20435	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HG267_20445	COG0724	RNA recognition motif
HG267_20450	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
HG267_20455	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HG267_20460	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
HG267_20465	COG3409	Peptidoglycan-binding domain 1 protein
HG267_20465	COG3429	Glucose-6-phosphate dehydrogenase subunit
HG267_20495	COG0039	L-malate dehydrogenase activity
HG267_20505	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
HG267_20525	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HG267_20530	COG0521	Mo-molybdopterin cofactor biosynthetic process
HG267_20540	COG1490	D-aminoacyl-tRNA deacylase activity
HG267_20545	COG0523	cobalamin synthesis protein
HG267_20550	COG0215	cysteine-tRNA ligase activity
HG267_20575	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
HG267_20625	COG3266	domain, Protein
HG267_20625	COG0515	serine threonine protein kinase
HG267_20650	COG3266	domain, Protein
HG267_20650	COG0515	serine threonine protein kinase
HG267_20665	COG3266	domain, Protein
HG267_20665	COG0515	serine threonine protein kinase
HG267_20670	COG0842	Transport permease protein
HG267_20670	COG1131	(ABC) transporter
HG267_20670	COG1716	ATPase activity
HG267_20675	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
HG267_20685	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
HG267_20695	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
HG267_20705	COG5002	protein histidine kinase activity
HG267_20720	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
HG267_20730	COG0515	serine threonine protein kinase
HG267_20730	COG3266	domain, Protein
HG267_20735	COG1902	pentaerythritol trinitrate reductase activity
HG267_20740	COG0667	Aldo Keto reductase
HG267_20745	COG2205	protein histidine kinase activity
HG267_20770	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
HG267_20785	COG2198	Histidine kinase
HG267_20785	COG2205	protein histidine kinase activity
HG267_20785	COG0784	Response regulator, receiver
HG267_20805	COG2319	Wd-40 repeat
HG267_20805	COG4249	Peptidase C14 caspase catalytic subunit p20
HG267_20810	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HG267_20815	COG0438	transferase activity, transferring glycosyl groups
HG267_20835	COG0438	transferase activity, transferring glycosyl groups
HG267_20855	COG1357	PFAM Pentapeptide repeats (8 copies)
HG267_20855	COG0515	serine threonine protein kinase
HG267_20860	COG1357	PFAM Pentapeptide repeats (8 copies)
HG267_20860	COG0515	serine threonine protein kinase
HG267_20875	COG0515	serine threonine protein kinase
HG267_20875	COG1357	PFAM Pentapeptide repeats (8 copies)
HG267_20880	COG3852	Histidine kinase
HG267_20895	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HG267_20905	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
HG267_20945	COG2205	protein histidine kinase activity
HG267_20945	COG0784	Response regulator, receiver
HG267_20945	COG5002	protein histidine kinase activity
HG267_20955	COG0571	ribonuclease III activity
HG267_20970	COG0598	Magnesium transport protein CorA
HG267_20985	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
HG267_20990	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HG267_20995	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
HG267_21000	COG0572	uridine kinase
HG267_21020	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
HG267_21025	COG0308	aminopeptidase N
HG267_21040	COG1970	mechanosensitive ion channel activity
HG267_21045	COG2226	methyltransferase
HG267_21060	COG0484	heat shock protein binding
HG267_21065	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HG267_21070	COG1959	2 iron, 2 sulfur cluster binding
HG267_21075	COG3659	wide pore channel activity
HG267_21080	COG2154	pterin-4-alpha-carbinolamine dehydratase
HG267_21100	COG1122	ATPase activity
HG267_21105	COG3688	RNA-binding protein containing a PIN domain
HG267_21115	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HG267_21125	COG0515	serine threonine protein kinase
HG267_21125	COG1357	PFAM Pentapeptide repeats (8 copies)
HG267_21150	COG0697	spore germination
HG267_21160	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
HG267_21175	COG4771	TonB-dependent receptor
HG267_21185	COG0784	Response regulator, receiver
HG267_21190	COG2205	protein histidine kinase activity
HG267_21190	COG2202	Pas domain
HG267_21210	COG2010	Cytochrome c
HG267_21220	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HG267_21225	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
HG267_21230	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HG267_21240	COG1803	Methylglyoxal synthase
HG267_21245	COG3437	response regulator, receiver
HG267_21245	COG4999	Histidine kinase
HG267_21245	COG2205	protein histidine kinase activity
HG267_21245	COG3850	Histidine kinase
HG267_21255	COG0481	GTPase activity
HG267_21275	COG1104	cysteine desulfurase activity
HG267_21300	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HG267_21330	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
HG267_21360	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
HG267_21360	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
HG267_21375	COG0482	sulfurtransferase activity
HG267_21385	COG0300	oxidoreductase activity
HG267_21410	COG0525	valine-tRNA ligase activity
HG267_21430	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
HG267_21435	COG4251	negative regulation of phosphorylation
HG267_21445	COG2205	protein histidine kinase activity
HG267_21450	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
HG267_21460	COG0702	epimerase
HG267_21465	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
HG267_21470	COG0745	RESPONSE REGULATOR receiver
HG267_21490	COG0134	indole-3-glycerol-phosphate synthase activity
HG267_21495	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HG267_21520	COG0288	reversible hydration of carbon dioxide
HG267_21535	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HG267_21540	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
HG267_21545	COG0484	heat shock protein binding
HG267_21555	COG0483	inositol monophosphate 1-phosphatase activity
HG267_21565	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HG267_21595	COG0667	Aldo Keto reductase
HG267_21640	COG2162	N-hydroxyarylamine O-acetyltransferase activity
HG267_21655	COG0443	Heat shock 70 kDa protein
HG267_21660	COG4294	response to UV
HG267_21670	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HG267_21680	COG0463	Glycosyl transferase, family 2
HG267_21720	COG0438	transferase activity, transferring glycosyl groups
HG267_21725	COG0110	maltose O-acetyltransferase activity
HG267_21745	COG0367	asparagine synthase
HG267_21750	COG0438	transferase activity, transferring glycosyl groups
HG267_21755	COG0438	transferase activity, transferring glycosyl groups
HG267_21770	COG0275	rRNA processing
HG267_21785	COG1216	Glycosyl transferase, family 2
HG267_21790	COG1216	Glycosyl transferase, family 2
HG267_21820	COG1442	glycosyl transferase family 8
HG267_21840	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HG267_21865	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
HG267_21885	COG0489	protein tyrosine kinase activity
HG267_21915	COG0784	Response regulator, receiver
HG267_21915	COG2198	Histidine kinase
HG267_21915	COG5002	protein histidine kinase activity
HG267_21920	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HG267_21945	COG2244	polysaccharide biosynthetic process
HG267_21955	COG1442	glycosyl transferase family 8
HG267_21955	COG1216	Glycosyl transferase, family 2
HG267_21960	COG1442	glycosyl transferase family 8
HG267_21960	COG1216	Glycosyl transferase, family 2
HG267_21975	COG5002	protein histidine kinase activity
HG267_21995	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HG267_22015	COG2501	S4 domain
HG267_22025	COG1573	uracil-dna glycosylase
HG267_22045	COG3236	hydrolase activity, hydrolyzing N-glycosyl compounds
HG267_22055	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
HG267_22060	COG2205	protein histidine kinase activity
HG267_22060	COG3437	response regulator, receiver
HG267_22060	COG3850	Histidine kinase
HG267_22060	COG4999	Histidine kinase
HG267_22070	COG3237	CsbD-like
HG267_22080	COG3659	wide pore channel activity
HG267_22095	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
HG267_22115	COG2201	protein-glutamate methylesterase activity
HG267_22120	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
HG267_22125	COG5002	protein histidine kinase activity
HG267_22175	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
HG267_22185	COG1253	flavin adenine dinucleotide binding
HG267_22195	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
HG267_22200	COG1598	PFAM Uncharacterised protein family UPF0150
HG267_22215	COG3033	Beta-eliminating lyase
HG267_22230	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HG267_22240	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
HG267_22245	COG0501	Belongs to the peptidase M48B family
HG267_22265	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
HG267_22270	COG2244	polysaccharide biosynthetic process
HG267_22275	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HG267_22280	COG0438	transferase activity, transferring glycosyl groups
HG267_22290	COG1216	Glycosyl transferase, family 2
HG267_22295	COG0463	Glycosyl transferase, family 2
HG267_22300	COG0562	UDP-galactopyranose mutase
HG267_22305	COG1215	transferase activity, transferring glycosyl groups
HG267_22310	COG0500	methyltransferase
HG267_22320	COG0438	transferase activity, transferring glycosyl groups
HG267_22345	COG0489	protein tyrosine kinase activity
HG267_22370	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
HG267_22400	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HG267_22405	COG4956	integral membrane protein (PIN domain superfamily)
HG267_22415	COG0346	lactoylglutathione lyase activity
HG267_22420	COG2304	oxidoreductase activity
HG267_22425	COG2304	oxidoreductase activity
HG267_22430	COG0740	serine-type endopeptidase activity
HG267_22435	COG0740	serine-type endopeptidase activity
HG267_22440	COG0484	heat shock protein binding
HG267_22465	COG0312	modulator of DNA gyrase
HG267_22480	COG0237	dephospho-CoA kinase activity
HG267_22485	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
HG267_22500	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
HG267_22505	COG2226	methyltransferase
HG267_22510	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HG267_22515	COG0569	domain protein
HG267_22560	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
HG267_22570	COG0792	nuclease activity
HG267_22580	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
HG267_22585	COG2815	serine threonine protein kinase
HG267_22585	COG0515	serine threonine protein kinase
HG267_22595	COG4251	negative regulation of phosphorylation
HG267_22595	COG3706	GGDEF domain
HG267_22595	COG2203	Gaf domain
HG267_22595	COG5001	Diguanylate cyclase
HG267_22600	COG1649	PFAM Uncharacterised BCR, COG1649
HG267_22615	COG2897	thiosulfate sulfurtransferase activity
HG267_22640	COG1846	Transcriptional regulator
HG267_22655	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HG267_22675	COG0438	transferase activity, transferring glycosyl groups
HG267_22680	COG5002	protein histidine kinase activity
HG267_22685	COG0745	RESPONSE REGULATOR receiver
HG267_22715	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
HG267_22720	COG0113	porphobilinogen synthase activity
HG267_22735	COG0022	dehydrogenase e1 component
HG267_22735	COG0508	dehydrogenase complex catalyzes the overall conversion of
HG267_22740	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HG267_22745	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HG267_22760	COG0454	-acetyltransferase
HG267_22770	COG0009	L-threonylcarbamoyladenylate synthase
HG267_22775	COG2890	protein-(glutamine-N5) methyltransferase activity
HG267_22790	COG0454	-acetyltransferase
HG267_22800	COG2267	carboxylic ester hydrolase activity
HG267_22805	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
HG267_22825	COG0194	GDP metabolic process
HG267_22830	COG2052	Domain of unknown function (DUF370)
HG267_22835	COG1305	Transglutaminase-like
HG267_22855	COG0142	geranyltranstransferase activity
HG267_22865	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
HG267_22870	COG0860	N-Acetylmuramoyl-L-alanine amidase
HG267_22875	COG0860	N-Acetylmuramoyl-L-alanine amidase
HG267_22880	COG0475	glutathione-regulated potassium exporter activity
HG267_22905	COG1077	Cell shape determining protein MreB Mrl
HG267_22935	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HG267_22935	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HG267_22960	COG3903	Transcriptional regulator
HG267_22960	COG2319	Wd-40 repeat
HG267_22975	COG0745	RESPONSE REGULATOR receiver
HG267_22980	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HG267_23005	COG2770	Histidine kinase
HG267_23005	COG3437	response regulator, receiver
HG267_23030	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
HG267_23040	COG0436	Aminotransferase
HG267_23055	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HG267_23060	COG1530	ribonuclease E activity
HG267_23065	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
HG267_23075	COG0077	Prephenate dehydratase
HG267_23080	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
HG267_23085	COG0051	transcription antitermination factor activity, RNA binding
HG267_23090	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
HG267_23095	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HG267_23100	COG0049	tRNA binding
HG267_23105	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
HG267_23110	COG0316	Belongs to the HesB IscA family
HG267_23120	COG0662	Cupin 2, conserved barrel domain protein
HG267_23120	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
HG267_23130	COG0070	glutamate synthase
HG267_23130	COG0069	glutamate synthase activity
HG267_23130	COG0067	glutamate synthase
HG267_23145	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
HG267_23165	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
HG267_23185	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
HG267_23200	COG0440	acetolactate synthase activity
HG267_23205	COG0300	oxidoreductase activity
HG267_23240	COG2070	2-Nitropropane dioxygenase
HG267_23280	COG3956	TIGRFAM MazG family protein
HG267_23285	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HG267_23290	COG4636	protein conserved in cyanobacteria
HG267_23295	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
HG267_23310	COG0431	NADPH-dependent FMN reductase
HG267_23315	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HG267_23335	COG0222	ribosome binding
HG267_23340	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
HG267_23345	COG0081	regulation of translation
HG267_23350	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
HG267_23355	COG0250	Participates in transcription elongation, termination and antitermination
HG267_23360	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HG267_23370	COG0335	large ribosomal subunit rRNA binding
HG267_23395	COG0724	RNA recognition motif
HG267_23400	COG0426	domain, Protein
HG267_23400	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HG267_23405	COG0426	domain, Protein
HG267_23405	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HG267_23410	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
HG267_23425	COG0025	NhaP-type Na H and K H
HG267_23445	COG0165	Argininosuccinate lyase
HG267_23460	COG1691	(AIR) carboxylase
HG267_23465	COG0747	negative chemotaxis
HG267_23480	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
HG267_23485	COG0336	Belongs to the RNA methyltransferase TrmD family
HG267_23495	COG4242	Belongs to the peptidase S51 family
HG267_23500	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HG267_23500	COG0189	ligase activity
HG267_23505	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HG267_23515	COG0515	serine threonine protein kinase
HG267_23515	COG3266	domain, Protein
HG267_23525	COG0575	Belongs to the CDS family
HG267_23535	COG1187	pseudouridine synthase activity
HG267_23540	COG1426	Protein conserved in bacteria
HG267_23545	COG1640	4-alpha-glucanotransferase
HG267_23555	COG0251	oxidation-reduction process
HG267_23595	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
HG267_23600	COG3639	organic phosphonate transmembrane transporter activity
HG267_23635	COG0783	Belongs to the Dps family
HG267_23640	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
HG267_23645	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HG267_23655	COG0494	nUDIX hydrolase
HG267_23660	COG0516	GMP reductase activity
HG267_23660	COG0517	IMP dehydrogenase activity
HG267_23695	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
HG267_23740	COG0779	Required for maturation of 30S ribosomal subunits
HG267_23745	COG0195	Participates in both transcription termination and antitermination
HG267_23755	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
HG267_23755	COG3266	domain, Protein
HG267_23775	COG1361	Conserved repeat domain
HG267_23805	COG3240	lipase activity
HG267_23825	COG0438	transferase activity, transferring glycosyl groups
HG267_23835	COG2205	protein histidine kinase activity
HG267_23840	COG4251	negative regulation of phosphorylation
HG267_23840	COG3706	GGDEF domain
HG267_23840	COG2203	Gaf domain
HG267_23840	COG5001	Diguanylate cyclase
HG267_23865	COG1295	ribonuclease BN
HG267_23895	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
HG267_23900	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
HG267_23905	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
HG267_23920	COG0697	spore germination
HG267_23925	COG0306	phosphate transporter
HG267_23930	COG1063	alcohol dehydrogenase
HG267_23935	COG0456	acetyltransferase
HG267_23940	COG3311	Transcriptional regulator
HG267_23970	COG3903	Transcriptional regulator
HG267_23970	COG2319	Wd-40 repeat
HG267_23975	COG0515	serine threonine protein kinase
HG267_23975	COG1357	PFAM Pentapeptide repeats (8 copies)
HG267_24010	COG0390	transport system, permease component
HG267_24025	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
HG267_24030	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HG267_24035	COG1132	(ABC) transporter
HG267_24045	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HG267_24060	COG2234	aminopeptidase activity
HG267_24115	COG0217	transcriptional regulatory protein
HG267_24125	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HG267_24130	COG0784	Response regulator, receiver
HG267_24130	COG2205	protein histidine kinase activity
HG267_24140	COG0741	lytic transglycosylase activity
HG267_24150	COG0805	protein transport
HG267_24155	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HG267_24160	COG3001	Fructosamine kinase
HG267_24165	COG0612	Peptidase, M16
HG267_24200	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
HG267_24210	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HG267_24220	COG0589	response to stress
HG267_24225	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
HG267_24230	COG0268	Binds directly to 16S ribosomal RNA
HG267_24235	COG0084	hydrolase, TatD family'
HG267_24240	COG0085	RNA polymerase activity
HG267_24245	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
HG267_24250	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
HG267_24265	COG1361	Conserved repeat domain
HG267_24270	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HG267_24280	COG0596	Alpha beta hydrolase
HG267_24290	COG1649	PFAM Uncharacterised BCR, COG1649
HG267_24300	COG4251	negative regulation of phosphorylation
HG267_24305	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HG267_24310	COG2202	Pas domain
HG267_24310	COG2205	protein histidine kinase activity
HG267_24325	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
HG267_24335	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HG267_24380	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HG267_24400	COG0017	Asparaginyl-tRNA synthetase
HG267_24410	COG3266	domain, Protein
HG267_24410	COG0515	serine threonine protein kinase
HG267_24420	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
HG267_24440	COG0589	response to stress
HG267_24445	COG0126	phosphoglycerate kinase activity
HG267_24495	COG0475	glutathione-regulated potassium exporter activity
HG267_24515	COG1803	Methylglyoxal synthase
HG267_24515	COG1597	lipid kinase activity
HG267_24525	COG1672	PFAM Archaeal ATPase
HG267_24525	COG2319	Wd-40 repeat
HG267_24555	COG0181	hydroxymethylbilane synthase activity
HG267_24560	COG0297	glycogen (starch) synthase activity
HG267_24570	COG5002	protein histidine kinase activity
HG267_24570	COG0784	Response regulator, receiver
HG267_24580	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
HG267_24640	COG2205	protein histidine kinase activity
HG267_24640	COG0784	Response regulator, receiver
HG267_24655	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
HG267_24680	COG0012	GTP binding
HG267_24690	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
HG267_24705	COG3118	belongs to the thioredoxin family
HG267_24710	COG0724	RNA recognition motif
HG267_24720	COG0724	RNA recognition motif
HG267_24735	COG3631	Ketosteroid isomerase-related protein
HG267_24740	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
HG267_24745	COG0546	phosphoglycolate phosphatase activity
HG267_24755	COG3631	Ketosteroid isomerase-related protein
HG267_24760	COG1136	(ABC) transporter
HG267_24780	COG4251	negative regulation of phosphorylation
HG267_24780	COG3706	GGDEF domain
HG267_24780	COG2203	Gaf domain
HG267_24780	COG5001	Diguanylate cyclase
HG267_24780	COG4251	negative regulation of phosphorylation
HG267_24780	COG3706	GGDEF domain
HG267_24780	COG2203	Gaf domain
HG267_24780	COG5001	Diguanylate cyclase
HG267_24785	COG3236	hydrolase activity, hydrolyzing N-glycosyl compounds
HG267_24795	COG0318	PFAM AMP-dependent synthetase and ligase
HG267_24810	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
HG267_24830	COG2205	protein histidine kinase activity
HG267_24830	COG0784	Response regulator, receiver
HG267_24835	COG3659	wide pore channel activity
HG267_24840	COG0803	Belongs to the bacterial solute-binding protein 9 family
HG267_24840	COG3443	Belongs to the bacterial solute-binding protein 9 family
HG267_24845	COG1121	(ABC) transporter
HG267_24850	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HG267_24890	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
HG267_24900	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
HG267_24905	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
HG267_24955	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HG267_24965	COG3629	intracellular signal transduction
HG267_24965	COG3903	Transcriptional regulator
HG267_25075	COG1529	Aldehyde oxidase and xanthine dehydrogenase
HG267_25080	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
HG267_25085	COG2080	2 iron, 2 sulfur cluster binding
HG267_25105	COG1266	CAAX protease self-immunity
HG267_25110	COG1266	CAAX protease self-immunity
HG267_25120	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
HG267_25120	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HG267_25130	COG2197	response regulator
HG267_25135	COG4585	Histidine kinase
HG267_25150	COG2807	transmembrane transport
HG267_25155	COG4771	TonB-dependent receptor
HG267_25180	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HG267_25180	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
HG267_25180	COG3321	synthase
HG267_25195	COG2010	Cytochrome c
HG267_25220	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
HG267_25230	COG1845	cytochrome c oxidase, subunit III
HG267_25250	COG2822	iron ion transport
HG267_25255	COG0672	)-iron permease
HG267_25315	COG0346	lactoylglutathione lyase activity
HG267_25325	COG0667	Aldo Keto reductase
HG267_25380	COG2207	Transcriptional regulator
HG267_25380	COG1917	Cupin 2, conserved barrel domain protein
HG267_25445	COG5285	phytanoyl-CoA dioxygenase
HG267_25495	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HG267_25540	COG0443	Heat shock 70 kDa protein
HG267_25555	COG2197	response regulator
HG267_25660	COG4249	Peptidase C14 caspase catalytic subunit p20
HG267_25660	COG2319	Wd-40 repeat
HG267_25720	COG0778	Nitroreductase
HG267_25740	COG1309	transcriptional regulator
HG267_25755	COG1122	ATPase activity
HG267_25785	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HG267_25790	COG1910	domain protein
HG267_25800	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HG267_25810	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
HG267_25815	COG1294	oxidase, subunit
HG267_25820	COG1271	oxidase subunit
HG267_25835	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
HG267_25845	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
HG267_25850	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
HG267_25860	COG1910	domain protein
HG267_25870	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HG267_25910	COG4249	Peptidase C14 caspase catalytic subunit p20
HG267_25910	COG2319	Wd-40 repeat
HG267_25915	COG2319	Wd-40 repeat
HG267_25915	COG4249	Peptidase C14 caspase catalytic subunit p20
HG267_25920	COG1672	PFAM Archaeal ATPase
HG267_25920	COG2319	Wd-40 repeat
HG267_26025	COG2319	Wd-40 repeat
HG267_26025	COG4249	Peptidase C14 caspase catalytic subunit p20
HG267_26055	COG1672	PFAM Archaeal ATPase
HG267_26055	COG2319	Wd-40 repeat
HG267_26100	COG0643	Histidine kinase
HG267_26100	COG0784	Response regulator, receiver
HG267_26100	COG2198	Histidine kinase
HG267_26105	COG2201	protein-glutamate methylesterase activity
HG267_26110	COG3292	Two component regulator propeller
HG267_26110	COG2205	protein histidine kinase activity
HG267_26110	COG0745	RESPONSE REGULATOR receiver
HG267_26125	COG1819	glycosyl
HG267_26130	COG1819	glycosyl
HG267_26135	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
HG267_26185	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
HG267_26190	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
HG267_26215	COG2815	serine threonine protein kinase
HG267_26215	COG0515	serine threonine protein kinase
HG267_26230	COG1116	anion transmembrane transporter activity
HG267_26240	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HG267_26250	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HG267_26255	COG1464	Belongs to the NlpA lipoprotein family
HG267_26305	COG1132	(ABC) transporter
HG267_26310	COG1132	(ABC) transporter
HG267_26315	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HG267_26330	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HG267_26390	COG2226	methyltransferase
HG267_26425	COG1132	(ABC) transporter
HG267_26430	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
HG267_26440	COG2207	Transcriptional regulator
HG267_26450	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
HG267_26480	COG4774	siderophore transport
HG267_26495	COG1120	ATPase activity
HG267_26500	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HG267_26505	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HG267_26510	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
HG267_26515	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
HG267_26520	COG0751	glycine-tRNA ligase activity
HG267_26530	COG2873	o-acetylhomoserine
HG267_26535	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HG267_26545	COG4221	oxidoreductase activity
HG267_26555	COG2814	Major facilitator Superfamily
HG267_26580	COG0154	amidase activity
HG267_26590	COG2197	response regulator
HG267_26595	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HG267_26620	COG3185	4-Hydroxyphenylpyruvate dioxygenase
HG267_26635	COG0438	transferase activity, transferring glycosyl groups
HG267_26645	COG1063	alcohol dehydrogenase
HG267_26695	COG1201	RNA secondary structure unwinding
HG267_26700	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HG267_26705	COG0581	inorganic phosphate transmembrane transporter activity
HG267_26710	COG0573	inorganic phosphate transmembrane transporter activity
HG267_26715	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
HG267_26725	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
HG267_26735	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HG267_26750	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HG267_26755	COG0601	transmembrane transport
HG267_26765	COG0129	dihydroxy-acid dehydratase activity
HG267_26770	COG1063	alcohol dehydrogenase
HG267_26830	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
HG267_26840	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
HG267_26845	COG0713	ATP synthesis coupled electron transport
HG267_26850	COG0839	Belongs to the complex I subunit 6 family
HG267_26855	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HG267_26860	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
HG267_26875	COG0372	Belongs to the citrate synthase family
HG267_26880	COG2062	phosphohistidine phosphatase, SixA
HG267_26895	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HG267_26905	COG0784	Response regulator, receiver
HG267_26920	COG0840	transmembrane signaling receptor activity
HG267_26920	COG2203	Gaf domain
HG267_26925	COG2198	Histidine kinase
HG267_26925	COG0784	Response regulator, receiver
HG267_26925	COG0643	Histidine kinase
HG267_26935	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HG267_26985	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
HG267_27000	COG1696	Membrane protein involved in D-alanine export
HG267_27020	COG2274	protein secretion by the type I secretion system
HG267_27070	COG4585	Histidine kinase
HG267_27080	COG2197	response regulator
HG267_27085	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HG267_27135	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HG267_27140	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
HG267_27145	COG0330	HflC and HflK could
HG267_27150	COG1515	deoxyribonuclease V activity
HG267_27185	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
HG267_27225	COG1132	(ABC) transporter
HG267_27245	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HG267_27255	COG0359	binds to the 23S rRNA
HG267_27260	COG1372	Participates in initiation and elongation during chromosome replication
HG267_27260	COG0305	Participates in initiation and elongation during chromosome replication
HG267_27290	COG0517	IMP dehydrogenase activity
HG267_27290	COG1994	Peptidase M50
HG267_27310	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
HG267_27325	COG1357	PFAM Pentapeptide repeats (8 copies)
HG267_27325	COG0515	serine threonine protein kinase
HG267_27335	COG0840	transmembrane signaling receptor activity
HG267_27335	COG2203	Gaf domain
HG267_27340	COG0745	RESPONSE REGULATOR receiver
HG267_27350	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
HG267_27355	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
HG267_27365	COG0745	RESPONSE REGULATOR receiver
HG267_27375	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
HG267_27380	COG0459	protein refolding
HG267_27395	COG1192	Involved in chromosome partitioning
HG267_27400	COG0829	nickel cation binding
HG267_27405	COG0831	urea catabolic process
HG267_27410	COG0832	Belongs to the urease beta subunit family
HG267_27420	COG0804	urea catabolic process
HG267_27455	COG1012	belongs to the aldehyde dehydrogenase family
HG267_27460	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
HG267_27465	COG0333	Belongs to the bacterial ribosomal protein bL32 family
HG267_27510	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
HG267_27515	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HG267_27520	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HG267_27525	COG0544	peptidyl-prolyl cis-trans isomerase activity
HG267_27530	COG0740	serine-type endopeptidase activity
HG267_27535	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
HG267_27555	COG2188	Transcriptional regulator
HG267_27560	COG0412	Dienelactone hydrolase
HG267_27565	COG0539	negative regulation of cytoplasmic translation
HG267_27600	COG0515	serine threonine protein kinase
HG267_27600	COG1357	PFAM Pentapeptide repeats (8 copies)
HG267_27635	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
HG267_27650	COG4999	Histidine kinase
HG267_27650	COG3850	Histidine kinase
HG267_27650	COG3437	response regulator, receiver
HG267_27650	COG2205	protein histidine kinase activity
HG267_27675	COG0539	negative regulation of cytoplasmic translation
HG267_27695	COG0747	negative chemotaxis
HG267_27700	COG0601	transmembrane transport
HG267_27725	COG2205	protein histidine kinase activity
HG267_27725	COG0784	Response regulator, receiver
HG267_27730	COG3852	Histidine kinase
HG267_27735	COG2884	Cell division ATP-binding protein ftsE
HG267_27745	COG2197	response regulator
HG267_27760	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HG267_27760	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
HG267_27770	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
HG267_27785	COG1316	TRANSCRIPTIONal
HG267_27795	COG0628	permease
HG267_27810	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HG267_27840	COG3237	CsbD-like
HG267_27850	COG0556	nucleotide-excision repair
HG267_27900	COG3585	molybdate ion transport
HG267_27915	COG0316	Belongs to the HesB IscA family
HG267_27920	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HG267_27930	COG5420	small protein containing a coiled-coil domain
HG267_27945	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
HG267_28040	COG0628	permease
HG267_28060	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
HG267_28070	COG0582	viral genome integration into host DNA
HG267_28080	COG1943	Transposase
HG267_28140	COG0412	Dienelactone hydrolase
HG267_28175	COG1028	Short-chain dehydrogenase reductase Sdr
HG267_28225	COG0582	viral genome integration into host DNA
HG267_28335	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
HG267_28345	COG2906	2 iron, 2 sulfur cluster binding
HG267_28345	COG0822	iron-sulfur transferase activity
HG267_28345	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
HG267_28400	COG0784	Response regulator, receiver
HG267_28400	COG2205	protein histidine kinase activity
HG267_28405	COG0745	RESPONSE REGULATOR receiver
HG267_28410	COG1595	DNA-templated transcription, initiation
HG267_28465	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
HG267_28530	COG0515	serine threonine protein kinase
HG267_28530	COG1357	PFAM Pentapeptide repeats (8 copies)
HG267_28570	COG1045	serine acetyltransferase
HG267_28585	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HG267_28590	COG5554	nitrogen fixation
HG267_28595	COG5554	nitrogen fixation
HG267_28635	COG0442	prolyl-tRNA aminoacylation
HG267_28645	COG0640	Transcriptional regulator
HG267_28650	COG0511	ligase activity, forming carbon-carbon bonds
HG267_28655	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
HG267_28665	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HG267_28675	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
HG267_28680	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HG267_28685	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
HG267_28690	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HG267_28695	COG0812	UDP-N-acetylmuramate dehydrogenase activity
HG267_28700	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
HG267_28705	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HG267_28710	COG0745	RESPONSE REGULATOR receiver
HG267_28715	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
HG267_28730	COG2205	protein histidine kinase activity
HG267_28730	COG0784	Response regulator, receiver
HG267_28730	COG2198	Histidine kinase
HG267_28765	COG1596	polysaccharide export
HG267_28770	COG3206	protein involved in exopolysaccharide biosynthesis
HG267_28770	COG0489	protein tyrosine kinase activity
HG267_28785	COG0745	RESPONSE REGULATOR receiver
HG267_28790	COG5002	protein histidine kinase activity
HG267_28970	COG5000	phosphorelay sensor kinase activity
HG267_28970	COG5002	protein histidine kinase activity
HG267_28980	COG0745	RESPONSE REGULATOR receiver
HG267_29005	COG4178	(ABC) transporter
HG267_29015	COG3845	ABC transporter
HG267_29055	COG0515	serine threonine protein kinase
HG267_29055	COG2815	serine threonine protein kinase
HG267_29125	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
HG267_29130	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HG267_29140	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
HG267_29145	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HG267_29150	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HG267_29155	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HG267_29165	COG1702	phosphate starvation-inducible protein PhoH
HG267_29170	COG0828	Belongs to the bacterial ribosomal protein bS21 family
HG267_29180	COG0228	four-way junction DNA binding
HG267_29185	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
HG267_29195	COG0006	proline dipeptidase activity
HG267_29210	COG5002	protein histidine kinase activity
HG267_29210	COG0784	Response regulator, receiver
HG267_29215	COG0384	phenazine biosynthesis protein PhzF
HG267_29235	COG0612	Peptidase, M16
HG267_29240	COG0612	Peptidase, M16
HG267_29245	COG0540	Belongs to the ATCase OTCase family
HG267_29250	COG2239	Acts as a magnesium transporter
HG267_29270	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
HG267_29280	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
HG267_29285	COG1695	Transcriptional regulator
HG267_29330	COG0445	tRNA wobble uridine modification
HG267_29345	COG3670	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
HG267_29360	COG0406	alpha-ribazole phosphatase activity
HG267_29380	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
HG267_29385	COG0564	pseudouridine synthase activity
HG267_29415	COG0697	spore germination
HG267_29435	COG2010	Cytochrome c
HG267_29480	COG2205	protein histidine kinase activity
HG267_29480	COG2202	Pas domain
HG267_29525	COG3629	intracellular signal transduction
HG267_29525	COG3903	Transcriptional regulator
HG267_29530	COG0006	proline dipeptidase activity
HG267_29545	COG0512	Glutamine amidotransferase of anthranilate synthase
HG267_29545	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HG267_29550	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
HG267_29555	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
HG267_29570	COG1657	PFAM Prenyltransferase squalene oxidase
HG267_29580	COG1215	transferase activity, transferring glycosyl groups
HG267_29590	COG0745	RESPONSE REGULATOR receiver
HG267_29595	COG2226	methyltransferase
HG267_29630	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HG267_29695	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
HG267_29710	COG4783	chaperone-mediated protein folding
HG267_29725	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HG267_29725	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
HG267_29730	COG3437	response regulator, receiver
HG267_29735	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
HG267_29740	COG2319	Wd-40 repeat
HG267_29745	COG1446	asparaginase
HG267_29760	COG0167	dihydroorotate dehydrogenase activity
HG267_29790	COG2304	oxidoreductase activity
HG267_29800	COG0784	Response regulator, receiver
HG267_29800	COG2205	protein histidine kinase activity
HG267_29810	COG0477	Major facilitator Superfamily
HG267_29815	COG1357	PFAM Pentapeptide repeats (8 copies)
HG267_29815	COG0515	serine threonine protein kinase
HG267_29825	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HG267_29845	COG0514	ATP-dependent DNA helicase (RecQ)
HG267_29860	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
HG267_29865	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
HG267_29870	COG1234	tRNA 3'-trailer cleavage
HG267_29875	COG0196	riboflavin kinase activity
HG267_29880	COG0714	Associated with various cellular activities
HG267_29895	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
HG267_29905	COG0312	modulator of DNA gyrase
HG267_29955	COG5001	Diguanylate cyclase
HG267_29955	COG4251	negative regulation of phosphorylation
HG267_29955	COG2203	Gaf domain
HG267_29955	COG5001	Diguanylate cyclase
HG267_29955	COG4251	negative regulation of phosphorylation
HG267_29955	COG3706	GGDEF domain
HG267_29955	COG2203	Gaf domain
HG267_29955	COG3706	GGDEF domain
HG267_29980	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HG267_29985	COG1120	ATPase activity
HG267_29990	COG0531	amino acid
HG267_30015	COG0523	cobalamin synthesis protein
HG267_30020	COG0302	gtp cyclohydrolase
HG267_30050	COG0113	porphobilinogen synthase activity
HG267_30060	COG1012	belongs to the aldehyde dehydrogenase family
HG267_30065	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
HG267_30075	COG0501	Belongs to the peptidase M48B family
HG267_30120	COG0515	serine threonine protein kinase
HG267_30130	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HG267_30135	COG4279	zinc finger
HG267_30170	COG0628	permease
HG267_30220	COG2119	membrane
HG267_30225	COG4581	dead DEAH box helicase
HG267_30235	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HG267_30240	COG1799	cell septum assembly
HG267_30245	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
HG267_30255	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HG267_30260	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
HG267_30265	COG1160	GTP binding
HG267_30315	COG1305	Transglutaminase-like
HG267_30325	COG0714	Associated with various cellular activities
HG267_30350	COG0598	Magnesium transport protein CorA
HG267_30355	COG0435	Glutathione S-transferase
HG267_30365	COG1819	glycosyl
HG267_30405	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
HG267_30425	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
HG267_30440	COG0488	(ABC) transporter
HG267_30460	COG1132	(ABC) transporter
HG267_30480	COG2124	cytochrome p450
HG267_30485	COG1192	Involved in chromosome partitioning
HG267_30505	COG3437	response regulator, receiver
HG267_30510	COG5002	protein histidine kinase activity
HG267_30545	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
HG267_30565	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HG267_30570	COG1233	COG1233 Phytoene dehydrogenase and related
HG267_30575	COG2954	triphosphatase activity
HG267_30615	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HG267_30625	COG0489	protein tyrosine kinase activity
HG267_30630	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HG267_30645	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
HG267_30655	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
HG267_30665	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HG267_30685	COG0438	transferase activity, transferring glycosyl groups
HG267_30715	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
HG267_30720	COG0045	succinate-CoA ligase (ADP-forming) activity
HG267_30860	COG4251	negative regulation of phosphorylation
HG267_30865	COG0784	Response regulator, receiver
HG267_30870	COG5002	protein histidine kinase activity
HG267_30885	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HG267_30890	COG1959	2 iron, 2 sulfur cluster binding
HG267_30895	COG1045	serine acetyltransferase
HG267_30905	COG0745	RESPONSE REGULATOR receiver
HG267_30940	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HG267_30975	COG0024	Methionine aminopeptidase
HG267_30995	COG2385	sporulation resulting in formation of a cellular spore
HG267_31005	COG0783	Belongs to the Dps family
HG267_31025	COG0745	RESPONSE REGULATOR receiver
HG267_31040	COG0515	serine threonine protein kinase
HG267_31040	COG3266	domain, Protein
HG267_31095	COG2340	Cysteine-rich secretory protein family
HG267_31110	COG2274	protein secretion by the type I secretion system
HG267_31115	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HG267_31125	COG5001	Diguanylate cyclase
HG267_31125	COG5001	Diguanylate cyclase
HG267_31125	COG4251	negative regulation of phosphorylation
HG267_31125	COG2203	Gaf domain
HG267_31125	COG3706	GGDEF domain
HG267_31125	COG4251	negative regulation of phosphorylation
HG267_31125	COG2203	Gaf domain
HG267_31125	COG3706	GGDEF domain
HG267_31135	COG0300	oxidoreductase activity
HG267_31155	COG2442	InterPro IPR007367
HG267_31160	COG4804	nuclease activity
HG267_31205	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
HG267_31235	COG0222	ribosome binding
HG267_31315	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HG267_31330	COG2304	oxidoreductase activity
HG267_31345	COG1132	(ABC) transporter
HG267_31350	COG0668	transmembrane transport
HG267_31355	COG1324	tolerance protein
HG267_31360	COG0033	Phosphoglucomutase
HG267_31440	COG1487	ribonuclease activity
HG267_31550	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HG267_31560	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HG267_31560	COG3320	Male sterility
HG267_31565	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
HG267_31565	COG2070	2-Nitropropane dioxygenase
HG267_31570	COG0300	oxidoreductase activity
HG267_31570	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HG267_31570	COG4221	oxidoreductase activity
HG267_31570	COG3321	synthase
HG267_31580	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HG267_31580	COG1028	Short-chain dehydrogenase reductase Sdr
HG267_31580	COG3321	synthase
HG267_31580	COG4221	oxidoreductase activity
HG267_31585	COG0604	alcohol dehydrogenase
HG267_31585	COG3321	synthase
HG267_31615	COG2852	Protein conserved in bacteria
HG267_31620	COG1475	DNA binding
HG267_31630	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HG267_31645	COG0463	Glycosyl transferase, family 2
HG267_31685	COG0815	Transfers the fatty acyl group on membrane lipoproteins
HG267_31695	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HG267_31710	COG0674	pyruvate-flavodoxin oxidoreductase activity
HG267_31710	COG1013	pyruvate-flavodoxin oxidoreductase activity
HG267_31710	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
HG267_31710	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
HG267_31715	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
HG267_31725	COG5398	heme oxygenase
HG267_31730	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HG267_31740	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
HG267_31775	COG0673	inositol 2-dehydrogenase activity
HG267_31785	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HG267_31810	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HG267_31825	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HG267_31855	COG0210	DNA helicase
HG267_31860	COG2203	Gaf domain
HG267_31860	COG5001	Diguanylate cyclase
HG267_31860	COG4251	negative regulation of phosphorylation
HG267_31860	COG3706	GGDEF domain
HG267_31880	COG0723	plastoquinol--plastocyanin reductase activity
HG267_31915	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HG267_31920	COG0110	maltose O-acetyltransferase activity
HG267_31950	COG2197	response regulator
HG267_31955	COG4585	Histidine kinase
HG267_31980	COG4231	catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates
HG267_32030	COG0714	Associated with various cellular activities
HG267_32035	COG3552	Protein containing von Willebrand factor type A (VWA) domain
HG267_32080	COG0745	RESPONSE REGULATOR receiver
HG267_32100	COG0606	chelatase, subunit chli
HG267_32105	COG0537	adenosine 5'-monophosphoramidase activity
HG267_32110	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
HG267_32115	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
HG267_32125	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HG267_32130	COG0735	belongs to the Fur family
HG267_32145	COG2202	Pas domain
HG267_32145	COG2205	protein histidine kinase activity
HG267_32155	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
HG267_32160	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
HG267_32175	COG5002	protein histidine kinase activity
HG267_32220	COG4636	protein conserved in cyanobacteria
HG267_32225	COG1361	Conserved repeat domain
HG267_32240	COG0556	nucleotide-excision repair
HG267_32245	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HG267_32250	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
HG267_32265	COG0515	serine threonine protein kinase
HG267_32265	COG3266	domain, Protein
HG267_32270	COG1845	cytochrome c oxidase, subunit III
HG267_32275	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HG267_32280	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
HG267_32290	COG0109	protoheme IX farnesyltransferase activity
HG267_32300	COG5002	protein histidine kinase activity
HG267_32300	COG2198	Histidine kinase
HG267_32300	COG0784	Response regulator, receiver
HG267_32310	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
HG267_32315	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
HG267_32360	COG0584	glycerophosphoryl diester phosphodiesterase
HG267_32370	COG0429	hydrolase of the alpha beta-hydrolase fold
HG267_32375	COG0745	RESPONSE REGULATOR receiver
HG267_32410	COG0157	Belongs to the NadC ModD family
HG267_32415	COG0426	domain, Protein
HG267_32415	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HG267_32420	COG0426	domain, Protein
HG267_32420	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HG267_32450	COG0778	Nitroreductase
HG267_32455	COG0667	Aldo Keto reductase
HG267_32460	COG2072	flavoprotein involved in K transport
HG267_32470	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HG267_32485	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HG267_32485	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HG267_32490	COG1028	Short-chain dehydrogenase reductase Sdr
HG267_32505	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HG267_32510	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HG267_32515	COG0697	spore germination
HG267_32540	COG4106	trans-aconitate 2-methyltransferase activity
HG267_32565	COG0346	lactoylglutathione lyase activity
HG267_32570	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HG267_32595	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HG267_32620	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HG267_32625	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HG267_32640	COG2226	methyltransferase
HG267_32650	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
HG267_32670	COG0456	acetyltransferase
HG267_32730	COG0432	Pfam Uncharacterised protein family UPF0047
HG267_32750	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
HG267_32780	COG0191	fructose-bisphosphate aldolase activity
HG267_32785	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
HG267_32790	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
HG267_32795	COG1254	Belongs to the acylphosphatase family
HG267_32805	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
HG267_32810	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HG267_32815	COG0189	ligase activity
HG267_32815	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HG267_32825	COG4242	Belongs to the peptidase S51 family
HG267_32845	COG0314	molybdopterin synthase activity
HG267_32860	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
HG267_32875	COG4783	chaperone-mediated protein folding
HG267_32890	COG1262	PFAM Formylglycine-generating sulfatase enzyme
HG267_32895	COG0668	transmembrane transport
HG267_32900	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HG267_32915	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HG267_32920	COG0456	acetyltransferase
HG267_32925	COG1324	tolerance protein
HG267_32930	COG2814	Major facilitator Superfamily
HG267_32935	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HG267_32945	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HG267_32990	COG0459	protein refolding
HG267_33005	COG0546	phosphoglycolate phosphatase activity
HG267_33130	COG4644	lycopene metabolic process
HG267_33155	COG0305	Participates in initiation and elongation during chromosome replication
HG267_33155	COG0305	Participates in initiation and elongation during chromosome replication
HG267_33155	COG1372	Participates in initiation and elongation during chromosome replication
HG267_33155	COG1372	Participates in initiation and elongation during chromosome replication
HG267_33185	COG0514	ATP-dependent DNA helicase (RecQ)
HG267_33250	COG0515	serine threonine protein kinase
HG267_33250	COG1357	PFAM Pentapeptide repeats (8 copies)
HG267_33270	COG0443	Heat shock 70 kDa protein
HG267_33330	COG1361	Conserved repeat domain
HG267_33345	COG1859	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase
HG267_33390	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
HG267_33445	COG1404	Belongs to the peptidase S8 family
HG267_33475	COG1404	Belongs to the peptidase S8 family
HG267_33495	COG0745	RESPONSE REGULATOR receiver
HG267_33500	COG5002	protein histidine kinase activity
HG267_33520	COG0515	serine threonine protein kinase
HG267_33530	COG0515	serine threonine protein kinase
HG267_33545	COG5002	protein histidine kinase activity
HG267_33550	COG0151	Belongs to the GarS family
HG267_33615	COG3394	polysaccharide catabolic process
HG267_33635	COG1480	7TM receptor with intracellular HD hydrolase
HG267_33645	COG0671	phosphoesterase, PA-phosphatase related
HG267_33650	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
HG267_33665	COG1252	NADH dehydrogenase
HG267_33675	COG1543	Belongs to the glycosyl hydrolase 57 family
HG267_33680	COG1162	GTPase activity
HG267_33690	COG0484	heat shock protein binding
HG267_33695	COG0443	Heat shock 70 kDa protein
HG267_33700	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
HG267_33705	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HG267_33715	COG1459	type II secretion system
HG267_33725	COG1748	Saccharopine dehydrogenase
HG267_33750	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HG267_33760	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HG267_33780	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HG267_33790	COG0038	chloride channel
HG267_33810	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
HG267_33840	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
HG267_33850	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
HG267_33870	COG0628	permease
HG267_33880	COG0811	peptide transport
HG267_33920	COG0640	Transcriptional regulator
HG267_33935	COG0581	inorganic phosphate transmembrane transporter activity
HG267_33940	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HG267_33970	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HG267_33975	COG2205	protein histidine kinase activity
HG267_34115	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
HG267_34135	COG0515	serine threonine protein kinase
HG267_34135	COG2815	serine threonine protein kinase
HG267_34155	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
HG267_34170	COG0697	spore germination
HG267_34175	COG0745	RESPONSE REGULATOR receiver
HG267_34190	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HG267_34200	COG2010	Cytochrome c
HG267_34220	COG1950	PFAM Membrane protein of
HG267_34230	COG2183	response to ionizing radiation
HG267_34235	COG0745	RESPONSE REGULATOR receiver
HG267_34245	COG1175	transmembrane transport
HG267_34250	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HG267_34280	COG1357	PFAM Pentapeptide repeats (8 copies)
HG267_34280	COG0515	serine threonine protein kinase
HG267_34295	COG1357	PFAM Pentapeptide repeats (8 copies)
HG267_34295	COG0515	serine threonine protein kinase
HG267_34305	COG0071	Belongs to the small heat shock protein (HSP20) family
HG267_34315	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
HG267_34320	COG0501	Belongs to the peptidase M48B family
HG267_34335	COG1309	transcriptional regulator
HG267_34355	COG2205	protein histidine kinase activity
HG267_34365	COG0784	Response regulator, receiver
HG267_34370	COG4251	negative regulation of phosphorylation
HG267_34385	COG0678	peroxiredoxin activity
HG267_34385	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
HG267_34395	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HG267_34395	COG4191	Histidine kinase
HG267_34415	COG1252	NADH dehydrogenase
HG267_34425	COG0386	Belongs to the glutathione peroxidase family
HG267_34445	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
HG267_34450	COG4191	Histidine kinase
HG267_34490	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HG267_34495	COG0778	Nitroreductase
HG267_34535	COG4191	Histidine kinase
HG267_34560	COG0515	serine threonine protein kinase
HG267_34585	COG4191	Histidine kinase
HG267_34635	COG2217	Heavy metal translocating P-type atpase
HG267_34655	COG0753	catalase activity
HG267_34660	COG1262	PFAM Formylglycine-generating sulfatase enzyme
HG267_34660	COG0515	serine threonine protein kinase
HG267_34665	COG0121	glutamine amidotransferase
HG267_34670	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HG267_34675	COG1959	2 iron, 2 sulfur cluster binding
HG267_34760	COG1231	oxidoreductase activity
HG267_34785	COG1672	PFAM Archaeal ATPase
HG267_34785	COG2319	Wd-40 repeat
HG267_34815	COG5002	protein histidine kinase activity
HG267_34830	COG1943	Transposase
HG267_34835	COG2205	protein histidine kinase activity
HG267_34835	COG0784	Response regulator, receiver
HG267_34850	COG0110	maltose O-acetyltransferase activity
HG267_34865	COG3210	domain, Protein
HG267_34885	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
HG267_34890	COG3228	Belongs to the MtfA family
HG267_34900	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HG267_34905	COG0561	phosphatase activity
HG267_34910	COG0632	four-way junction helicase activity
HG267_34915	COG0156	8-amino-7-oxononanoate synthase activity
HG267_34935	COG2815	serine threonine protein kinase
HG267_34935	COG0515	serine threonine protein kinase
HG267_34945	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
HG267_34990	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HG267_35010	COG0475	glutathione-regulated potassium exporter activity
HG267_35020	COG0475	glutathione-regulated potassium exporter activity
HG267_35055	COG0419	ATPase involved in DNA repair
HG267_35085	COG2223	nitrite transmembrane transporter activity
HG267_35100	COG0456	acetyltransferase
HG267_35125	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
HG267_35145	COG0745	RESPONSE REGULATOR receiver
HG267_35175	COG0138	bifunctional purine biosynthesis protein purh
HG267_35185	COG3536	Protein conserved in bacteria
HG267_35190	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
HG267_35200	COG2205	protein histidine kinase activity
HG267_35200	COG0784	Response regulator, receiver
HG267_35205	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
HG267_35210	COG0830	nickel cation binding
HG267_35215	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
HG267_35220	COG0415	Belongs to the DNA photolyase family
HG267_35280	COG0339	signal peptide processing
HG267_35385	COG0828	Belongs to the bacterial ribosomal protein bS21 family
HG267_35390	COG0724	RNA recognition motif
HG267_35410	COG4106	trans-aconitate 2-methyltransferase activity
HG267_35435	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HG267_35450	COG2207	Transcriptional regulator
HG267_35450	COG3708	Transcriptional regulator
HG267_35455	COG0667	Aldo Keto reductase
HG267_35465	COG0783	Belongs to the Dps family
HG267_35470	COG1741	Belongs to the pirin family
HG267_35505	COG2319	Wd-40 repeat
HG267_35520	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
HG267_35525	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
HG267_35525	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
HG267_35530	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
HG267_35535	COG2066	Belongs to the glutaminase family
HG267_35550	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
HG267_35560	COG2205	protein histidine kinase activity
HG267_35560	COG5002	protein histidine kinase activity
HG267_35560	COG0784	Response regulator, receiver
HG267_35570	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
HG267_35580	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
HG267_35590	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HG267_35590	COG2205	protein histidine kinase activity
HG267_35600	COG2197	response regulator
HG267_35655	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
HG267_35665	COG0018	arginyl-trna synthetase
HG267_35680	COG3210	domain, Protein
HG267_35690	COG3210	domain, Protein
HG267_35755	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HG267_35760	COG0730	response to heat
HG267_35770	COG0330	HflC and HflK could
HG267_35790	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HG267_35795	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
HG267_35800	COG1028	Short-chain dehydrogenase reductase Sdr
HG267_35850	COG0668	transmembrane transport
HG267_35865	COG0748	coenzyme F420 binding
HG267_35875	COG1289	transmembrane transporter activity
HG267_35880	COG0318	PFAM AMP-dependent synthetase and ligase
HG267_35890	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
HG267_35895	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
HG267_35920	COG0582	viral genome integration into host DNA
HG267_35940	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
HG267_35960	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
HG267_36000	COG2217	Heavy metal translocating P-type atpase
HG267_36015	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HG267_36045	COG1012	belongs to the aldehyde dehydrogenase family
HG267_36055	COG0318	PFAM AMP-dependent synthetase and ligase
HG267_36060	COG0318	PFAM AMP-dependent synthetase and ligase
HG267_36080	COG4106	trans-aconitate 2-methyltransferase activity
HG267_36085	COG2223	nitrite transmembrane transporter activity
HG267_36110	COG5002	protein histidine kinase activity
HG267_36135	COG1132	(ABC) transporter
HG267_36140	COG0588	phosphoglycerate mutase activity
HG267_36200	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
HG267_36200	COG2755	lipolytic protein G-D-S-L family
HG267_36215	COG4191	Histidine kinase
HG267_36215	COG2205	protein histidine kinase activity
HG267_36215	COG0745	RESPONSE REGULATOR receiver
HG267_36240	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
HG267_36250	COG1116	anion transmembrane transporter activity
HG267_36255	COG1116	anion transmembrane transporter activity
HG267_36255	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HG267_36260	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HG267_36265	COG3437	response regulator, receiver
HG267_36265	COG3850	Histidine kinase
HG267_36265	COG4999	Histidine kinase
HG267_36265	COG2205	protein histidine kinase activity
HG267_36270	COG0571	ribonuclease III activity
HG267_36300	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
HG267_36300	COG1240	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
HG267_36315	COG0670	Belongs to the BI1 family
HG267_36335	COG0515	serine threonine protein kinase
HG267_36350	COG5002	protein histidine kinase activity
HG267_36350	COG0784	Response regulator, receiver
HG267_36370	COG0731	radical SAM domain protein
HG267_36405	COG1285	pathogenesis
HG267_36415	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
HG267_36425	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
HG267_36440	COG0358	DNA primase activity
HG267_36500	COG1120	ATPase activity
HG267_36510	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HG267_36545	COG0640	Transcriptional regulator
HG267_36580	COG1993	acr, cog1993
HG267_36595	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HG267_36605	COG0745	RESPONSE REGULATOR receiver
HG267_36610	COG5002	protein histidine kinase activity
HG267_36695	COG0398	Pfam SNARE associated Golgi protein
HG267_36700	COG0589	response to stress
HG267_36710	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HG267_36715	COG0745	RESPONSE REGULATOR receiver
HG267_36720	COG5002	protein histidine kinase activity
HG267_36725	COG1475	DNA binding
HG267_36730	COG1192	Involved in chromosome partitioning
HG267_36755	COG1132	(ABC) transporter
HG267_36765	COG0470	DNA polymerase III
HG267_36790	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
HG267_36795	COG0592	DNA-directed DNA polymerase activity
HG267_36880	COG1111	helicase
HG267_36880	COG1205	dead DEAH box helicase
HG267_36885	COG1216	Glycosyl transferase, family 2
HG267_36885	COG1442	glycosyl transferase family 8
HG267_37000	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HG267_37035	COG4474	Belongs to the UPF0398 family
HG267_37115	COG2319	Wd-40 repeat
HG267_37115	COG4249	Peptidase C14 caspase catalytic subunit p20
HG267_37125	COG4249	Peptidase C14 caspase catalytic subunit p20
HG267_37125	COG2319	Wd-40 repeat
HG267_37240	COG0739	heme binding
HG267_37315	COG2197	response regulator
HG267_37425	COG2217	Heavy metal translocating P-type atpase
HG267_37455	COG2226	methyltransferase
HG267_37490	COG5002	protein histidine kinase activity
HG267_37870	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HG267_37970	COG0305	Participates in initiation and elongation during chromosome replication
HG267_37970	COG1372	Participates in initiation and elongation during chromosome replication
HG267_37970	COG0305	Participates in initiation and elongation during chromosome replication
HG267_37970	COG1372	Participates in initiation and elongation during chromosome replication
HG267_38000	COG1475	DNA binding
HG267_38005	COG1192	Involved in chromosome partitioning
HG267_38050	COG0515	serine threonine protein kinase
HG267_38050	COG2815	serine threonine protein kinase
HG267_38150	COG0542	response to heat
HG267_38195	COG4680	protein conserved in bacteria
HG267_38440	COG0582	viral genome integration into host DNA
HG267_38660	COG2274	protein secretion by the type I secretion system
HG267_38685	COG1475	DNA binding
HG267_38695	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HG267_38725	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HG267_38870	COG0604	alcohol dehydrogenase
HG267_38870	COG3321	synthase
HG267_38875	COG3321	synthase
HG267_38875	COG0604	alcohol dehydrogenase
HG267_38890	COG0529	Catalyzes the synthesis of activated sulfate
HG267_38930	COG1819	glycosyl
HG267_38955	COG4974	Belongs to the 'phage' integrase family
HG267_38960	COG3209	COG3209 Rhs family protein
HG267_39200	COG1404	Belongs to the peptidase S8 family
HG267_39270	COG1475	DNA binding
HG267_39390	COG0582	viral genome integration into host DNA
HG267_39440	COG1404	Belongs to the peptidase S8 family
HG267_39515	COG1475	DNA binding
HG267_39690	COG4683	PFAM Phage derived protein Gp49-like (DUF891)
HG267_39785	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
HG267_39845	COG1192	Involved in chromosome partitioning
HG267_39850	COG1475	DNA binding
HG267_39865	COG1475	DNA binding
HG267_40015	COG4974	Belongs to the 'phage' integrase family
HG267_40020	COG2319	Wd-40 repeat
HG267_40020	COG5635	Nacht domain
HG267_40050	COG1475	DNA binding
HG267_40060	COG0724	RNA recognition motif
HG267_40065	COG0828	Belongs to the bacterial ribosomal protein bS21 family
HG267_40085	COG2319	Wd-40 repeat
HG267_40085	COG4249	Peptidase C14 caspase catalytic subunit p20
HG267_40180	COG1487	ribonuclease activity
HG267_40220	COG1475	DNA binding
HG267_40225	COG1192	Involved in chromosome partitioning
HG267_40260	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HG267_40265	COG0071	Belongs to the small heat shock protein (HSP20) family
HG267_40475	COG0582	viral genome integration into host DNA
HG267_40515	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HG267_40525	COG1475	DNA binding
HG267_40565	COG2319	Wd-40 repeat
HG267_40565	COG4249	Peptidase C14 caspase catalytic subunit p20
HG267_40580	COG0828	Belongs to the bacterial ribosomal protein bS21 family
HG267_40585	COG0724	RNA recognition motif
HG267_40640	COG0582	viral genome integration into host DNA
HG267_40785	COG1672	PFAM Archaeal ATPase
HG267_40785	COG2319	Wd-40 repeat
HG267_40805	COG4974	Belongs to the 'phage' integrase family
HG267_40905	COG3629	intracellular signal transduction
HG267_40905	COG3903	Transcriptional regulator
HG267_40915	COG1192	Involved in chromosome partitioning
HG267_40930	COG0582	viral genome integration into host DNA
HG267_41030	COG3591	Belongs to the peptidase S1B family
HG267_41030	COG1864	DNA RNA non-specific endonuclease
HG267_41105	COG0582	viral genome integration into host DNA
HG267_41125	COG1695	Transcriptional regulator
HG267_41205	COG3344	reverse transcriptase
HG267_41355	COG1192	Involved in chromosome partitioning
HG267_41380	COG4974	Belongs to the 'phage' integrase family
HG267_41535	COG4974	Belongs to the 'phage' integrase family