locus-tag	class	description
HCG51_00005	COG5002	protein histidine kinase activity
HCG51_00005	COG3850	Histidine kinase
HCG51_00010	COG0784	Response regulator, receiver
HCG51_00015	COG4251	negative regulation of phosphorylation
HCG51_00040	COG0484	heat shock protein binding
HCG51_00055	COG1122	ATPase activity
HCG51_00065	COG1930	Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import
HCG51_00070	COG0310	cobalt ion transport
HCG51_00090	COG0587	DNA-directed DNA polymerase activity
HCG51_00095	COG0154	amidase activity
HCG51_00100	COG2945	thiolester hydrolase activity
HCG51_00115	COG0436	Aminotransferase
HCG51_00120	COG0371	Dehydrogenase
HCG51_00135	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
HCG51_00140	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
HCG51_00170	COG4221	oxidoreductase activity
HCG51_00175	COG3903	Transcriptional regulator
HCG51_00175	COG2319	Wd-40 repeat
HCG51_00200	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
HCG51_00240	COG2076	Multidrug Resistance protein
HCG51_00260	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
HCG51_00265	COG2201	protein-glutamate methylesterase activity
HCG51_00280	COG2203	Gaf domain
HCG51_00280	COG0840	transmembrane signaling receptor activity
HCG51_00285	COG2198	Histidine kinase
HCG51_00285	COG0643	Histidine kinase
HCG51_00285	COG0784	Response regulator, receiver
HCG51_00290	COG2203	Gaf domain
HCG51_00290	COG3706	GGDEF domain
HCG51_00290	COG5001	Diguanylate cyclase
HCG51_00290	COG4251	negative regulation of phosphorylation
HCG51_00295	COG1176	ABC-type spermidine putrescine transport system, permease component I
HCG51_00310	COG3842	ATPase activity
HCG51_00315	COG0768	penicillin binding
HCG51_00320	COG0768	penicillin binding
HCG51_00325	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
HCG51_00330	COG0587	DNA-directed DNA polymerase activity
HCG51_00395	COG1131	(ABC) transporter
HCG51_00420	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HCG51_00425	COG1846	Transcriptional regulator
HCG51_00435	COG0515	serine threonine protein kinase
HCG51_00435	COG1357	PFAM Pentapeptide repeats (8 copies)
HCG51_00445	COG1177	transmembrane transport
HCG51_00450	COG0438	transferase activity, transferring glycosyl groups
HCG51_00460	COG2515	1-aminocyclopropane-1-carboxylate deaminase
HCG51_00495	COG0095	Lipoate-protein ligase
HCG51_00505	COG1649	PFAM Uncharacterised BCR, COG1649
HCG51_00510	COG0737	Belongs to the 5'-nucleotidase family
HCG51_00540	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
HCG51_00545	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
HCG51_00545	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
HCG51_00550	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
HCG51_00555	COG2066	Belongs to the glutaminase family
HCG51_00570	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
HCG51_00580	COG0673	inositol 2-dehydrogenase activity
HCG51_00585	COG1881	PFAM PEBP family protein
HCG51_00595	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HCG51_00605	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HCG51_00625	COG4106	trans-aconitate 2-methyltransferase activity
HCG51_00635	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
HCG51_00640	COG0667	Aldo Keto reductase
HCG51_00675	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HCG51_00685	COG0535	radical SAM domain protein
HCG51_00745	COG1446	asparaginase
HCG51_00750	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
HCG51_00760	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HCG51_00805	COG0778	Nitroreductase
HCG51_00815	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HCG51_00845	COG5001	Diguanylate cyclase
HCG51_00850	COG2217	Heavy metal translocating P-type atpase
HCG51_00880	COG0121	glutamine amidotransferase
HCG51_00885	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HCG51_00890	COG1959	2 iron, 2 sulfur cluster binding
HCG51_00935	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HCG51_00950	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HCG51_00965	COG0724	RNA recognition motif
HCG51_00970	COG0828	Belongs to the bacterial ribosomal protein bS21 family
HCG51_00990	COG1252	NADH dehydrogenase
HCG51_00995	COG2205	protein histidine kinase activity
HCG51_01005	COG0277	FAD linked oxidase domain protein
HCG51_01010	COG0247	lactate metabolic process
HCG51_01020	COG2211	Major facilitator Superfamily
HCG51_01025	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
HCG51_01080	COG3266	domain, Protein
HCG51_01080	COG2911	Protein conserved in bacteria
HCG51_01080	COG1361	Conserved repeat domain
HCG51_01090	COG0583	DNA-binding transcription factor activity
HCG51_01200	COG0811	peptide transport
HCG51_01205	COG0848	biopolymer transport protein
HCG51_01210	COG0628	permease
HCG51_01230	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
HCG51_01240	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
HCG51_01260	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
HCG51_01330	COG2197	response regulator
HCG51_01360	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
HCG51_01360	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
HCG51_01360	COG1013	pyruvate-flavodoxin oxidoreductase activity
HCG51_01360	COG0674	pyruvate-flavodoxin oxidoreductase activity
HCG51_01370	COG0339	signal peptide processing
HCG51_01380	COG1309	transcriptional regulator
HCG51_01385	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
HCG51_01390	COG0784	Response regulator, receiver
HCG51_01390	COG2205	protein histidine kinase activity
HCG51_01390	COG5002	protein histidine kinase activity
HCG51_01415	COG0784	Response regulator, receiver
HCG51_01415	COG5002	protein histidine kinase activity
HCG51_01420	COG0731	radical SAM domain protein
HCG51_01450	COG3266	domain, Protein
HCG51_01450	COG0515	serine threonine protein kinase
HCG51_01455	COG0515	serine threonine protein kinase
HCG51_01465	COG5002	protein histidine kinase activity
HCG51_01470	COG0745	RESPONSE REGULATOR receiver
HCG51_01500	COG3386	PFAM SMP-30 Gluconolaconase
HCG51_01510	COG0628	permease
HCG51_01525	COG1028	Short-chain dehydrogenase reductase Sdr
HCG51_01530	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
HCG51_01530	COG3408	Glycogen debranching enzyme
HCG51_01555	COG0501	Belongs to the peptidase M48B family
HCG51_01560	COG0071	Belongs to the small heat shock protein (HSP20) family
HCG51_01570	COG1357	PFAM Pentapeptide repeats (8 copies)
HCG51_01570	COG0515	serine threonine protein kinase
HCG51_01575	COG1357	PFAM Pentapeptide repeats (8 copies)
HCG51_01575	COG0515	serine threonine protein kinase
HCG51_01585	COG1011	Hydrolase
HCG51_01605	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HCG51_01610	COG1175	transmembrane transport
HCG51_01620	COG0745	RESPONSE REGULATOR receiver
HCG51_01625	COG2183	response to ionizing radiation
HCG51_01635	COG1950	PFAM Membrane protein of
HCG51_01655	COG2010	Cytochrome c
HCG51_01665	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HCG51_01670	COG0745	RESPONSE REGULATOR receiver
HCG51_01675	COG0697	spore germination
HCG51_01690	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
HCG51_01700	COG0501	Belongs to the peptidase M48B family
HCG51_01705	COG1704	LemA family
HCG51_01710	COG0778	Nitroreductase
HCG51_01725	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
HCG51_01745	COG2205	protein histidine kinase activity
HCG51_01750	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HCG51_01775	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HCG51_01780	COG0581	inorganic phosphate transmembrane transporter activity
HCG51_01795	COG0640	Transcriptional regulator
HCG51_01835	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
HCG51_01890	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HCG51_01900	COG0515	serine threonine protein kinase
HCG51_01900	COG1357	PFAM Pentapeptide repeats (8 copies)
HCG51_01920	COG2885	chlorophyll binding
HCG51_01925	COG4932	domain protein
HCG51_01935	COG0515	serine threonine protein kinase
HCG51_01935	COG3266	domain, Protein
HCG51_01945	COG0123	including yeast histone deacetylase and acetoin utilization protein
HCG51_01995	COG1063	alcohol dehydrogenase
HCG51_02040	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
HCG51_02055	COG0386	Belongs to the glutathione peroxidase family
HCG51_02065	COG1252	NADH dehydrogenase
HCG51_02075	COG1845	cytochrome c oxidase, subunit III
HCG51_02080	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HCG51_02085	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
HCG51_02105	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
HCG51_02105	COG0678	peroxiredoxin activity
HCG51_02110	COG4251	negative regulation of phosphorylation
HCG51_02115	COG0784	Response regulator, receiver
HCG51_02125	COG2205	protein histidine kinase activity
HCG51_02145	COG1309	transcriptional regulator
HCG51_02160	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HCG51_02225	COG5398	heme oxygenase
HCG51_02230	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HCG51_02250	COG0438	transferase activity, transferring glycosyl groups
HCG51_02255	COG0438	transferase activity, transferring glycosyl groups
HCG51_02260	COG0450	alkyl hydroperoxide reductase
HCG51_02270	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
HCG51_02275	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
HCG51_02330	COG1366	Belongs to the anti-sigma-factor antagonist family
HCG51_02335	COG1366	Belongs to the anti-sigma-factor antagonist family
HCG51_02345	COG0392	lysyltransferase activity
HCG51_02345	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
HCG51_02355	COG2076	Multidrug Resistance protein
HCG51_02360	COG0723	plastoquinol--plastocyanin reductase activity
HCG51_02365	COG1309	transcriptional regulator
HCG51_02370	COG2239	Acts as a magnesium transporter
HCG51_02375	COG2133	pyrroloquinoline quinone binding
HCG51_02390	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HCG51_02395	COG0398	Pfam SNARE associated Golgi protein
HCG51_02405	COG0398	Pfam SNARE associated Golgi protein
HCG51_02430	COG4636	protein conserved in cyanobacteria
HCG51_02455	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
HCG51_02465	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
HCG51_02480	COG0473	3-isopropylmalate dehydrogenase activity
HCG51_02485	COG0668	transmembrane transport
HCG51_02495	COG3335	DDE superfamily endonuclease
HCG51_02520	COG1125	glycine betaine transport
HCG51_02520	COG0517	IMP dehydrogenase activity
HCG51_02560	COG3706	GGDEF domain
HCG51_02560	COG4251	negative regulation of phosphorylation
HCG51_02560	COG5001	Diguanylate cyclase
HCG51_02560	COG2203	Gaf domain
HCG51_02580	COG0784	Response regulator, receiver
HCG51_02600	COG0564	pseudouridine synthase activity
HCG51_02605	COG3118	belongs to the thioredoxin family
HCG51_02610	COG2264	protein methyltransferase activity
HCG51_02615	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HCG51_02620	COG0515	serine threonine protein kinase
HCG51_02620	COG1357	PFAM Pentapeptide repeats (8 copies)
HCG51_02665	COG1487	ribonuclease activity
HCG51_02695	COG0432	Pfam Uncharacterised protein family UPF0047
HCG51_02700	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
HCG51_02715	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
HCG51_02735	COG0582	viral genome integration into host DNA
HCG51_02765	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
HCG51_02770	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
HCG51_02780	COG0318	PFAM AMP-dependent synthetase and ligase
HCG51_02785	COG1289	transmembrane transporter activity
HCG51_02795	COG0748	coenzyme F420 binding
HCG51_02810	COG0668	transmembrane transport
HCG51_02870	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HCG51_02875	COG2226	methyltransferase
HCG51_02910	COG0222	ribosome binding
HCG51_02965	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
HCG51_02970	COG0667	Aldo Keto reductase
HCG51_02975	COG3659	wide pore channel activity
HCG51_02980	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HCG51_03020	COG0778	Nitroreductase
HCG51_03030	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HCG51_03035	COG2175	clavaminate synthase activity
HCG51_03040	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HCG51_03045	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HCG51_03050	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HCG51_03055	COG0431	NADPH-dependent FMN reductase
HCG51_03065	COG0745	RESPONSE REGULATOR receiver
HCG51_03080	COG1324	tolerance protein
HCG51_03095	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
HCG51_03105	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
HCG51_03125	COG0589	response to stress
HCG51_03130	COG2217	Heavy metal translocating P-type atpase
HCG51_03140	COG1262	PFAM Formylglycine-generating sulfatase enzyme
HCG51_03145	COG2217	Heavy metal translocating P-type atpase
HCG51_03150	COG1475	DNA binding
HCG51_03185	COG0288	reversible hydration of carbon dioxide
HCG51_03200	COG2832	Protein of unknown function (DUF454)
HCG51_03210	COG0387	Pfam Sodium calcium exchanger
HCG51_03220	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HCG51_03230	COG2319	Wd-40 repeat
HCG51_03230	COG4249	Peptidase C14 caspase catalytic subunit p20
HCG51_03255	COG2319	Wd-40 repeat
HCG51_03290	COG2319	Wd-40 repeat
HCG51_03290	COG1672	PFAM Archaeal ATPase
HCG51_03300	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HCG51_03315	COG0330	HflC and HflK could
HCG51_03325	COG0730	response to heat
HCG51_03340	COG1181	Belongs to the D-alanine--D-alanine ligase family
HCG51_03355	COG0288	reversible hydration of carbon dioxide
HCG51_03365	COG0667	Aldo Keto reductase
HCG51_03385	COG2954	triphosphatase activity
HCG51_03390	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HCG51_03410	COG1914	H( )-stimulated, divalent metal cation uptake system
HCG51_03430	COG2205	protein histidine kinase activity
HCG51_03430	COG0784	Response regulator, receiver
HCG51_03445	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
HCG51_03450	COG0667	Aldo Keto reductase
HCG51_03465	COG1956	GAF domain-containing protein
HCG51_03485	COG1464	Belongs to the NlpA lipoprotein family
HCG51_03505	COG0625	glutathione transferase activity
HCG51_03515	COG2252	PERMEase
HCG51_03525	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HCG51_03540	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HCG51_03560	COG0412	Dienelactone hydrolase
HCG51_03565	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HCG51_03575	COG0561	phosphatase activity
HCG51_03595	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HCG51_03640	COG2873	o-acetylhomoserine
HCG51_03645	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HCG51_03655	COG2011	ABC-type metal ion transport system permease component
HCG51_03665	COG1464	Belongs to the NlpA lipoprotein family
HCG51_03680	COG1116	anion transmembrane transporter activity
HCG51_03695	COG4221	oxidoreductase activity
HCG51_03700	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HCG51_03705	COG2814	Major facilitator Superfamily
HCG51_03715	COG0346	lactoylglutathione lyase activity
HCG51_03720	COG3453	Protein conserved in bacteria
HCG51_03720	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HCG51_03740	COG4106	trans-aconitate 2-methyltransferase activity
HCG51_03745	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HCG51_03760	COG2226	methyltransferase
HCG51_03770	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
HCG51_03790	COG4106	trans-aconitate 2-methyltransferase activity
HCG51_03820	COG0697	spore germination
HCG51_03825	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HCG51_03830	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HCG51_03840	COG1028	Short-chain dehydrogenase reductase Sdr
HCG51_03860	COG0604	alcohol dehydrogenase
HCG51_03875	COG1247	-acetyltransferase
HCG51_03880	COG2897	thiosulfate sulfurtransferase activity
HCG51_03890	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HCG51_03890	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HCG51_03900	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HCG51_03910	COG2072	flavoprotein involved in K transport
HCG51_03920	COG0667	Aldo Keto reductase
HCG51_03925	COG1132	(ABC) transporter
HCG51_03930	COG4122	O-methyltransferase activity
HCG51_03935	COG0723	plastoquinol--plastocyanin reductase activity
HCG51_03940	COG0625	glutathione transferase activity
HCG51_03970	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HCG51_03975	COG0456	acetyltransferase
HCG51_03980	COG1324	tolerance protein
HCG51_03985	COG2814	Major facilitator Superfamily
HCG51_03990	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HCG51_03995	COG2175	clavaminate synthase activity
HCG51_04000	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HCG51_04010	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HCG51_04015	COG0601	transmembrane transport
HCG51_04025	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HCG51_04055	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HCG51_04065	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
HCG51_04070	COG0459	protein refolding
HCG51_04095	COG1262	PFAM Formylglycine-generating sulfatase enzyme
HCG51_04110	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HCG51_04115	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HCG51_04125	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HCG51_04135	COG0573	inorganic phosphate transmembrane transporter activity
HCG51_04140	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
HCG51_04145	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
HCG51_04170	COG3659	wide pore channel activity
HCG51_04175	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
HCG51_04180	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
HCG51_04185	COG3639	organic phosphonate transmembrane transporter activity
HCG51_04200	COG3624	Phosphonate C-P lyase system protein PhnG
HCG51_04205	COG3625	alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity
HCG51_04215	COG3626	phosphonate metabolism
HCG51_04220	COG3454	Phosphonate metabolism
HCG51_04230	COG3627	carbon phosphorus lyase activity
HCG51_04235	COG4107	phosphonate C-P lyase system protein PhnK
HCG51_04240	COG4778	phosphonate C-P lyase system protein PhnL
HCG51_04245	COG3454	Phosphonate metabolism
HCG51_04250	COG0318	PFAM AMP-dependent synthetase and ligase
HCG51_04265	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
HCG51_04315	COG0784	Response regulator, receiver
HCG51_04315	COG2205	protein histidine kinase activity
HCG51_04320	COG1943	Transposase
HCG51_04340	COG5002	protein histidine kinase activity
HCG51_04355	COG0318	PFAM AMP-dependent synthetase and ligase
HCG51_04370	COG4221	oxidoreductase activity
HCG51_04370	COG3321	synthase
HCG51_04370	COG0300	oxidoreductase activity
HCG51_04370	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HCG51_04375	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
HCG51_04405	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
HCG51_04410	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HCG51_04425	COG2988	succinylglutamate desuccinylase activity
HCG51_04430	COG0583	DNA-binding transcription factor activity
HCG51_04460	COG2319	Wd-40 repeat
HCG51_04460	COG4249	Peptidase C14 caspase catalytic subunit p20
HCG51_04465	COG2252	PERMEase
HCG51_04470	COG1404	Belongs to the peptidase S8 family
HCG51_04505	COG0071	Belongs to the small heat shock protein (HSP20) family
HCG51_04535	COG4566	intracellular signal transduction
HCG51_04540	COG2205	protein histidine kinase activity
HCG51_04550	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HCG51_04575	COG2815	serine threonine protein kinase
HCG51_04575	COG0515	serine threonine protein kinase
HCG51_04595	COG0840	transmembrane signaling receptor activity
HCG51_04595	COG2203	Gaf domain
HCG51_04600	COG0784	Response regulator, receiver
HCG51_04635	COG0515	serine threonine protein kinase
HCG51_04640	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HCG51_04645	COG1121	(ABC) transporter
HCG51_04680	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HCG51_04690	COG3320	Male sterility
HCG51_04690	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HCG51_04695	COG2070	2-Nitropropane dioxygenase
HCG51_04695	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
HCG51_04700	COG4221	oxidoreductase activity
HCG51_04700	COG3321	synthase
HCG51_04700	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HCG51_04700	COG0300	oxidoreductase activity
HCG51_04710	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HCG51_04710	COG1028	Short-chain dehydrogenase reductase Sdr
HCG51_04710	COG3321	synthase
HCG51_04710	COG4221	oxidoreductase activity
HCG51_04715	COG3321	synthase
HCG51_04715	COG0604	alcohol dehydrogenase
HCG51_04750	COG1475	DNA binding
HCG51_04760	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HCG51_04775	COG1215	transferase activity, transferring glycosyl groups
HCG51_04805	COG0300	oxidoreductase activity
HCG51_04815	COG0815	Transfers the fatty acyl group on membrane lipoproteins
HCG51_04820	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HCG51_04835	COG0745	RESPONSE REGULATOR receiver
HCG51_04845	COG0110	maltose O-acetyltransferase activity
HCG51_04865	COG3903	Transcriptional regulator
HCG51_04865	COG3629	intracellular signal transduction
HCG51_04885	COG0038	chloride channel
HCG51_04895	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HCG51_04910	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HCG51_04940	COG0671	phosphoesterase, PA-phosphatase related
HCG51_04945	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
HCG51_04950	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
HCG51_04950	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
HCG51_04960	COG1252	NADH dehydrogenase
HCG51_04965	COG1543	Belongs to the glycosyl hydrolase 57 family
HCG51_04970	COG1162	GTPase activity
HCG51_04980	COG0484	heat shock protein binding
HCG51_04985	COG0443	Heat shock 70 kDa protein
HCG51_04990	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
HCG51_04995	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HCG51_05005	COG1459	type II secretion system
HCG51_05020	COG1480	7TM receptor with intracellular HD hydrolase
HCG51_05035	COG3394	polysaccharide catabolic process
HCG51_05040	COG2815	serine threonine protein kinase
HCG51_05040	COG0515	serine threonine protein kinase
HCG51_05105	COG0151	Belongs to the GarS family
HCG51_05110	COG5002	protein histidine kinase activity
HCG51_05120	COG2346	COG2346, Truncated hemoglobins
HCG51_05170	COG1361	Conserved repeat domain
HCG51_05180	COG1859	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase
HCG51_05190	COG0604	alcohol dehydrogenase
HCG51_05195	COG0412	Dienelactone hydrolase
HCG51_05240	COG0539	negative regulation of cytoplasmic translation
HCG51_05305	COG0747	negative chemotaxis
HCG51_05335	COG2205	protein histidine kinase activity
HCG51_05335	COG0784	Response regulator, receiver
HCG51_05345	COG2884	Cell division ATP-binding protein ftsE
HCG51_05355	COG2197	response regulator
HCG51_05375	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HCG51_05375	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
HCG51_05385	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
HCG51_05400	COG1316	TRANSCRIPTIONal
HCG51_05410	COG0628	permease
HCG51_05425	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HCG51_05465	COG3237	CsbD-like
HCG51_05475	COG0556	nucleotide-excision repair
HCG51_05530	COG3585	molybdate ion transport
HCG51_05545	COG0316	Belongs to the HesB IscA family
HCG51_05550	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HCG51_05560	COG5420	small protein containing a coiled-coil domain
HCG51_05575	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
HCG51_05660	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
HCG51_05670	COG0582	viral genome integration into host DNA
HCG51_05695	COG4191	Histidine kinase
HCG51_05715	COG0412	Dienelactone hydrolase
HCG51_05735	COG1733	regulation of RNA biosynthetic process
HCG51_05740	COG1902	pentaerythritol trinitrate reductase activity
HCG51_05765	COG1028	Short-chain dehydrogenase reductase Sdr
HCG51_05795	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
HCG51_05795	COG0822	iron-sulfur transferase activity
HCG51_05795	COG2906	2 iron, 2 sulfur cluster binding
HCG51_05810	COG0583	DNA-binding transcription factor activity
HCG51_05835	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
HCG51_05840	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
HCG51_05845	COG3781	membrane
HCG51_05850	COG3781	membrane
HCG51_05865	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
HCG51_05890	COG4636	protein conserved in cyanobacteria
HCG51_05915	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
HCG51_05945	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
HCG51_05990	COG1487	ribonuclease activity
HCG51_06015	COG1045	serine acetyltransferase
HCG51_06030	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HCG51_06035	COG5554	nitrogen fixation
HCG51_06040	COG5554	nitrogen fixation
HCG51_06065	COG0442	prolyl-tRNA aminoacylation
HCG51_06075	COG0640	Transcriptional regulator
HCG51_06080	COG0511	ligase activity, forming carbon-carbon bonds
HCG51_06085	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
HCG51_06090	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HCG51_06100	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
HCG51_06105	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HCG51_06110	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
HCG51_06115	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HCG51_06120	COG0812	UDP-N-acetylmuramate dehydrogenase activity
HCG51_06125	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
HCG51_06130	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HCG51_06135	COG0745	RESPONSE REGULATOR receiver
HCG51_06140	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
HCG51_06155	COG2198	Histidine kinase
HCG51_06155	COG0784	Response regulator, receiver
HCG51_06155	COG2205	protein histidine kinase activity
HCG51_06175	COG1596	polysaccharide export
HCG51_06180	COG3206	protein involved in exopolysaccharide biosynthesis
HCG51_06180	COG0489	protein tyrosine kinase activity
HCG51_06195	COG0745	RESPONSE REGULATOR receiver
HCG51_06200	COG5002	protein histidine kinase activity
HCG51_06350	COG2226	methyltransferase
HCG51_06360	COG2909	trisaccharide binding
HCG51_06385	COG5000	phosphorelay sensor kinase activity
HCG51_06385	COG5002	protein histidine kinase activity
HCG51_06390	COG0745	RESPONSE REGULATOR receiver
HCG51_06420	COG3386	PFAM SMP-30 Gluconolaconase
HCG51_06425	COG4178	(ABC) transporter
HCG51_06480	COG3335	DDE superfamily endonuclease
HCG51_06550	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
HCG51_06555	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HCG51_06560	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
HCG51_06565	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HCG51_06570	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HCG51_06575	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HCG51_06590	COG1702	phosphate starvation-inducible protein PhoH
HCG51_06595	COG0828	Belongs to the bacterial ribosomal protein bS21 family
HCG51_06605	COG0228	four-way junction DNA binding
HCG51_06610	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
HCG51_06620	COG0006	proline dipeptidase activity
HCG51_06630	COG0784	Response regulator, receiver
HCG51_06630	COG5002	protein histidine kinase activity
HCG51_06635	COG0384	phenazine biosynthesis protein PhzF
HCG51_06655	COG0612	Peptidase, M16
HCG51_06660	COG0612	Peptidase, M16
HCG51_06710	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HCG51_06730	COG2274	protein secretion by the type I secretion system
HCG51_06745	COG0540	Belongs to the ATCase OTCase family
HCG51_06750	COG2239	Acts as a magnesium transporter
HCG51_06780	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
HCG51_06790	COG0515	serine threonine protein kinase
HCG51_06790	COG1357	PFAM Pentapeptide repeats (8 copies)
HCG51_06800	COG2119	membrane
HCG51_06815	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
HCG51_06815	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
HCG51_06820	COG0515	serine threonine protein kinase
HCG51_06820	COG2815	serine threonine protein kinase
HCG51_06880	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HCG51_06890	COG2003	Belongs to the UPF0758 family
HCG51_06895	COG0066	3-isopropylmalate dehydratase activity
HCG51_06900	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
HCG51_06915	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
HCG51_06920	COG0408	coproporphyrinogen oxidase activity
HCG51_06960	COG0438	transferase activity, transferring glycosyl groups
HCG51_06960	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
HCG51_06965	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HCG51_06975	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HCG51_06980	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
HCG51_07000	COG1132	(ABC) transporter
HCG51_07010	COG2226	methyltransferase
HCG51_07015	COG0438	transferase activity, transferring glycosyl groups
HCG51_07025	COG1216	Glycosyl transferase, family 2
HCG51_07035	COG0435	Glutathione S-transferase
HCG51_07060	COG2203	Gaf domain
HCG51_07060	COG5001	Diguanylate cyclase
HCG51_07060	COG5001	Diguanylate cyclase
HCG51_07060	COG3706	GGDEF domain
HCG51_07060	COG4251	negative regulation of phosphorylation
HCG51_07060	COG3706	GGDEF domain
HCG51_07060	COG4251	negative regulation of phosphorylation
HCG51_07060	COG2203	Gaf domain
HCG51_07085	COG4191	Histidine kinase
HCG51_07110	COG0515	serine threonine protein kinase
HCG51_07115	COG0702	epimerase
HCG51_07120	COG0432	Pfam Uncharacterised protein family UPF0047
HCG51_07140	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
HCG51_07215	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
HCG51_07225	COG1254	Belongs to the acylphosphatase family
HCG51_07235	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
HCG51_07240	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HCG51_07245	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HCG51_07245	COG0189	ligase activity
HCG51_07255	COG4242	Belongs to the peptidase S51 family
HCG51_07265	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
HCG51_07275	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
HCG51_07280	COG1695	Transcriptional regulator
HCG51_07335	COG3670	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
HCG51_07345	COG0406	alpha-ribazole phosphatase activity
HCG51_07365	COG0564	pseudouridine synthase activity
HCG51_07390	COG0697	spore germination
HCG51_07410	COG2010	Cytochrome c
HCG51_07445	COG2205	protein histidine kinase activity
HCG51_07445	COG2202	Pas domain
HCG51_07480	COG3744	PilT protein domain protein
HCG51_07505	COG0006	proline dipeptidase activity
HCG51_07520	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HCG51_07520	COG0512	Glutamine amidotransferase of anthranilate synthase
HCG51_07525	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
HCG51_07530	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
HCG51_07545	COG1657	PFAM Prenyltransferase squalene oxidase
HCG51_07555	COG1215	transferase activity, transferring glycosyl groups
HCG51_07565	COG0745	RESPONSE REGULATOR receiver
HCG51_07570	COG2226	methyltransferase
HCG51_07610	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HCG51_07675	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
HCG51_07690	COG4783	chaperone-mediated protein folding
HCG51_07695	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
HCG51_07705	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
HCG51_07705	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HCG51_07710	COG3437	response regulator, receiver
HCG51_07715	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
HCG51_07720	COG2319	Wd-40 repeat
HCG51_07725	COG1446	asparaginase
HCG51_07740	COG0167	dihydroorotate dehydrogenase activity
HCG51_07770	COG2304	oxidoreductase activity
HCG51_07780	COG0784	Response regulator, receiver
HCG51_07780	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HCG51_07780	COG2205	protein histidine kinase activity
HCG51_07780	COG2198	Histidine kinase
HCG51_07785	COG0477	Major facilitator Superfamily
HCG51_07790	COG1357	PFAM Pentapeptide repeats (8 copies)
HCG51_07790	COG0515	serine threonine protein kinase
HCG51_07800	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HCG51_07810	COG0514	ATP-dependent DNA helicase (RecQ)
HCG51_07815	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
HCG51_07820	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
HCG51_07825	COG1234	tRNA 3'-trailer cleavage
HCG51_07830	COG0196	riboflavin kinase activity
HCG51_07835	COG0714	Associated with various cellular activities
HCG51_07855	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
HCG51_07910	COG5001	Diguanylate cyclase
HCG51_07910	COG2203	Gaf domain
HCG51_07910	COG3706	GGDEF domain
HCG51_07910	COG4251	negative regulation of phosphorylation
HCG51_07915	COG0531	amino acid
HCG51_07950	COG1012	belongs to the aldehyde dehydrogenase family
HCG51_07970	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
HCG51_07975	COG0501	Belongs to the peptidase M48B family
HCG51_08030	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HCG51_08035	COG4279	zinc finger
HCG51_08065	COG0628	permease
HCG51_08095	COG2205	protein histidine kinase activity
HCG51_08095	COG0784	Response regulator, receiver
HCG51_08105	COG2119	membrane
HCG51_08110	COG4581	dead DEAH box helicase
HCG51_08115	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HCG51_08120	COG1799	cell septum assembly
HCG51_08125	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
HCG51_08135	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HCG51_08140	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
HCG51_08145	COG1160	GTP binding
HCG51_08160	COG1192	Involved in chromosome partitioning
HCG51_08180	COG3237	CsbD-like
HCG51_08190	COG0784	Response regulator, receiver
HCG51_08190	COG2205	protein histidine kinase activity
HCG51_08195	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
HCG51_08210	COG3236	hydrolase activity, hydrolyzing N-glycosyl compounds
HCG51_08225	COG1573	uracil-dna glycosylase
HCG51_08240	COG4999	Histidine kinase
HCG51_08240	COG3437	response regulator, receiver
HCG51_08240	COG3850	Histidine kinase
HCG51_08240	COG2205	protein histidine kinase activity
HCG51_08270	COG0157	Belongs to the NadC ModD family
HCG51_08275	COG0598	Magnesium transport protein CorA
HCG51_08285	COG1012	belongs to the aldehyde dehydrogenase family
HCG51_08285	COG1454	alcohol dehydrogenase
HCG51_08290	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
HCG51_08295	COG1882	Formate acetyltransferase
HCG51_08305	COG0714	Associated with various cellular activities
HCG51_08315	COG1305	Transglutaminase-like
HCG51_08350	COG1216	Glycosyl transferase, family 2
HCG51_08360	COG4636	protein conserved in cyanobacteria
HCG51_08365	COG0140	phosphoribosyl-ATP diphosphatase activity
HCG51_08365	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
HCG51_08375	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
HCG51_08385	COG1215	transferase activity, transferring glycosyl groups
HCG51_08395	COG0745	RESPONSE REGULATOR receiver
HCG51_08410	COG1845	cytochrome c oxidase, subunit III
HCG51_08420	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
HCG51_08440	COG1012	belongs to the aldehyde dehydrogenase family
HCG51_08450	COG0314	molybdopterin synthase activity
HCG51_08480	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
HCG51_08510	COG1672	PFAM Archaeal ATPase
HCG51_08510	COG2319	Wd-40 repeat
HCG51_08515	COG1752	Esterase of the alpha-beta hydrolase superfamily
HCG51_08525	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
HCG51_08555	COG0314	molybdopterin synthase activity
HCG51_08570	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
HCG51_08580	COG2723	6-phospho-beta-galactosidase activity
HCG51_08590	COG4783	chaperone-mediated protein folding
HCG51_08600	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HCG51_08600	COG0426	domain, Protein
HCG51_08630	COG1426	Protein conserved in bacteria
HCG51_08635	COG2856	Zn peptidase
HCG51_08665	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HCG51_08760	COG0202	RNA polymerase activity
HCG51_08770	COG0418	dihydroorotase activity
HCG51_08785	COG1192	Involved in chromosome partitioning
HCG51_08790	COG2205	protein histidine kinase activity
HCG51_08795	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HCG51_08935	COG1234	tRNA 3'-trailer cleavage
HCG51_08955	COG0745	RESPONSE REGULATOR receiver
HCG51_08960	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
HCG51_08965	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
HCG51_08975	COG1704	LemA family
HCG51_08980	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
HCG51_09015	COG0515	serine threonine protein kinase
HCG51_09050	COG0539	negative regulation of cytoplasmic translation
HCG51_09055	COG0412	Dienelactone hydrolase
HCG51_09060	COG2188	Transcriptional regulator
HCG51_09080	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HCG51_09090	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
HCG51_09095	COG0740	serine-type endopeptidase activity
HCG51_09100	COG0544	peptidyl-prolyl cis-trans isomerase activity
HCG51_09105	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HCG51_09110	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HCG51_09115	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
HCG51_09120	COG0464	growth
HCG51_09145	COG0333	Belongs to the bacterial ribosomal protein bL32 family
HCG51_09150	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
HCG51_09155	COG1012	belongs to the aldehyde dehydrogenase family
HCG51_09185	COG0804	urea catabolic process
HCG51_09195	COG0832	Belongs to the urease beta subunit family
HCG51_09200	COG0831	urea catabolic process
HCG51_09205	COG0829	nickel cation binding
HCG51_09225	COG0459	protein refolding
HCG51_09230	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
HCG51_09240	COG3292	Two component regulator propeller
HCG51_09240	COG2205	protein histidine kinase activity
HCG51_09240	COG0745	RESPONSE REGULATOR receiver
HCG51_09245	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
HCG51_09250	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
HCG51_09255	COG2205	protein histidine kinase activity
HCG51_09260	COG0745	RESPONSE REGULATOR receiver
HCG51_09265	COG2203	Gaf domain
HCG51_09265	COG0840	transmembrane signaling receptor activity
HCG51_09275	COG1357	PFAM Pentapeptide repeats (8 copies)
HCG51_09275	COG0515	serine threonine protein kinase
HCG51_09280	COG1940	carbohydrate kinase activity
HCG51_09295	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
HCG51_09315	COG1262	PFAM Formylglycine-generating sulfatase enzyme
HCG51_09335	COG3591	Belongs to the peptidase S1B family
HCG51_09335	COG1864	DNA RNA non-specific endonuclease
HCG51_09340	COG1994	Peptidase M50
HCG51_09340	COG0517	IMP dehydrogenase activity
HCG51_09370	COG0305	Participates in initiation and elongation during chromosome replication
HCG51_09370	COG1372	Participates in initiation and elongation during chromosome replication
HCG51_09375	COG0359	binds to the 23S rRNA
HCG51_09385	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HCG51_09405	COG1132	(ABC) transporter
HCG51_09445	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
HCG51_09475	COG1515	deoxyribonuclease V activity
HCG51_09485	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
HCG51_09515	COG4106	trans-aconitate 2-methyltransferase activity
HCG51_09530	COG1160	GTP binding
HCG51_09540	COG1304	FMN binding
HCG51_09545	COG0616	signal peptide processing
HCG51_09590	COG2070	2-Nitropropane dioxygenase
HCG51_09615	COG3956	TIGRFAM MazG family protein
HCG51_09620	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HCG51_09625	COG1012	belongs to the aldehyde dehydrogenase family
HCG51_09675	COG0230	Belongs to the bacterial ribosomal protein bL34 family
HCG51_09680	COG0594	ribonuclease P activity
HCG51_09690	COG0706	membrane insertase activity
HCG51_09705	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HCG51_09720	COG5001	Diguanylate cyclase
HCG51_09720	COG1716	ATPase activity
HCG51_09725	COG2912	Transglutaminase-like superfamily
HCG51_09730	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
HCG51_09735	COG0355	proton-transporting ATP synthase activity, rotational mechanism
HCG51_09750	COG2203	Gaf domain
HCG51_09750	COG5001	Diguanylate cyclase
HCG51_09750	COG3706	GGDEF domain
HCG51_09750	COG4251	negative regulation of phosphorylation
HCG51_09755	COG3236	hydrolase activity, hydrolyzing N-glycosyl compounds
HCG51_09765	COG0318	PFAM AMP-dependent synthetase and ligase
HCG51_09780	COG2166	iron-sulfur cluster assembly
HCG51_09815	COG0523	cobalamin synthesis protein
HCG51_09830	COG1201	RNA secondary structure unwinding
HCG51_09835	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HCG51_09840	COG0581	inorganic phosphate transmembrane transporter activity
HCG51_09845	COG0573	inorganic phosphate transmembrane transporter activity
HCG51_09860	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
HCG51_09870	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HCG51_09885	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HCG51_09890	COG0601	transmembrane transport
HCG51_09930	COG0129	dihydroxy-acid dehydratase activity
HCG51_09935	COG1063	alcohol dehydrogenase
HCG51_09985	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
HCG51_09985	COG0352	thiamine-phosphate diphosphorylase activity
HCG51_09985	COG0351	phosphomethylpyrimidine kinase
HCG51_09995	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
HCG51_10000	COG0713	ATP synthesis coupled electron transport
HCG51_10005	COG0839	Belongs to the complex I subunit 6 family
HCG51_10010	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HCG51_10015	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
HCG51_10030	COG0372	Belongs to the citrate synthase family
HCG51_10035	COG2062	phosphohistidine phosphatase, SixA
HCG51_10055	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HCG51_10065	COG0784	Response regulator, receiver
HCG51_10080	COG2203	Gaf domain
HCG51_10080	COG0840	transmembrane signaling receptor activity
HCG51_10085	COG0784	Response regulator, receiver
HCG51_10085	COG0643	Histidine kinase
HCG51_10085	COG2198	Histidine kinase
HCG51_10095	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HCG51_10120	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
HCG51_10135	COG1696	Membrane protein involved in D-alanine export
HCG51_10155	COG2274	protein secretion by the type I secretion system
HCG51_10210	COG4585	Histidine kinase
HCG51_10220	COG2197	response regulator
HCG51_10230	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
HCG51_10235	COG0751	glycine-tRNA ligase activity
HCG51_10265	COG1404	Belongs to the peptidase S8 family
HCG51_10310	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
HCG51_10320	COG0671	phosphoesterase, PA-phosphatase related
HCG51_10365	COG3842	ATPase activity
HCG51_10400	COG0535	radical SAM domain protein
HCG51_10430	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HCG51_10485	COG3540	Alkaline phosphatase
HCG51_10510	COG0640	Transcriptional regulator
HCG51_10515	COG0798	PFAM Bile acid sodium symporter
HCG51_10520	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HCG51_10530	COG0431	NADPH-dependent FMN reductase
HCG51_10550	COG1959	2 iron, 2 sulfur cluster binding
HCG51_10685	COG4178	(ABC) transporter
HCG51_10695	COG3621	Patatin-like phospholipase
HCG51_10715	COG4178	(ABC) transporter
HCG51_10740	COG0318	PFAM AMP-dependent synthetase and ligase
HCG51_10745	COG2319	Wd-40 repeat
HCG51_10745	COG1672	PFAM Archaeal ATPase
HCG51_10770	COG0668	transmembrane transport
HCG51_10830	COG0529	Catalyzes the synthesis of activated sulfate
HCG51_10835	COG1682	transport, permease protein
HCG51_10915	COG1216	Glycosyl transferase, family 2
HCG51_10955	COG2814	Major facilitator Superfamily
HCG51_11000	COG0625	glutathione transferase activity
HCG51_11050	COG4191	Histidine kinase
HCG51_11055	COG3540	Alkaline phosphatase
HCG51_11250	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
HCG51_11255	COG0776	regulation of translation
HCG51_11280	COG1518	maintenance of DNA repeat elements
HCG51_11280	COG1468	defense response to virus
HCG51_11310	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
HCG51_11425	COG0305	Participates in initiation and elongation during chromosome replication
HCG51_11425	COG0305	Participates in initiation and elongation during chromosome replication
HCG51_11425	COG1372	Participates in initiation and elongation during chromosome replication
HCG51_11425	COG1372	Participates in initiation and elongation during chromosome replication
HCG51_11465	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HCG51_11545	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HCG51_11550	COG1121	(ABC) transporter
HCG51_11555	COG3443	Belongs to the bacterial solute-binding protein 9 family
HCG51_11555	COG0803	Belongs to the bacterial solute-binding protein 9 family
HCG51_11560	COG3659	wide pore channel activity
HCG51_11565	COG2205	protein histidine kinase activity
HCG51_11565	COG0784	Response regulator, receiver
HCG51_11585	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
HCG51_11595	COG3903	Transcriptional regulator
HCG51_11595	COG2319	Wd-40 repeat
HCG51_11600	COG1357	PFAM Pentapeptide repeats (8 copies)
HCG51_11600	COG0515	serine threonine protein kinase
HCG51_11625	COG0300	oxidoreductase activity
HCG51_11630	COG0440	acetolactate synthase activity
HCG51_11645	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
HCG51_11655	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
HCG51_11675	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
HCG51_11690	COG0067	glutamate synthase
HCG51_11690	COG0069	glutamate synthase activity
HCG51_11690	COG0070	glutamate synthase
HCG51_11700	COG0662	Cupin 2, conserved barrel domain protein
HCG51_11700	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
HCG51_11705	COG0316	Belongs to the HesB IscA family
HCG51_11710	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
HCG51_11715	COG0049	tRNA binding
HCG51_11720	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HCG51_11725	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
HCG51_11730	COG0051	transcription antitermination factor activity, RNA binding
HCG51_11735	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
HCG51_11740	COG0077	Prephenate dehydratase
HCG51_11750	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
HCG51_11755	COG1530	ribonuclease E activity
HCG51_11760	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HCG51_11775	COG0436	Aminotransferase
HCG51_11785	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
HCG51_11795	COG3335	DDE superfamily endonuclease
HCG51_11830	COG3437	response regulator, receiver
HCG51_11830	COG2770	Histidine kinase
HCG51_11855	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HCG51_11860	COG0745	RESPONSE REGULATOR receiver
HCG51_11870	COG3903	Transcriptional regulator
HCG51_11870	COG2319	Wd-40 repeat
HCG51_11895	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HCG51_11895	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HCG51_11910	COG1077	Cell shape determining protein MreB Mrl
HCG51_11915	COG0629	single-stranded DNA binding
HCG51_11930	COG0475	glutathione-regulated potassium exporter activity
HCG51_11940	COG0860	N-Acetylmuramoyl-L-alanine amidase
HCG51_11950	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
HCG51_11960	COG0142	geranyltranstransferase activity
HCG51_11980	COG1305	Transglutaminase-like
HCG51_11985	COG2052	Domain of unknown function (DUF370)
HCG51_11990	COG0194	GDP metabolic process
HCG51_12010	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
HCG51_12015	COG2267	carboxylic ester hydrolase activity
HCG51_12025	COG0454	-acetyltransferase
HCG51_12040	COG2890	protein-(glutamine-N5) methyltransferase activity
HCG51_12050	COG4999	Histidine kinase
HCG51_12050	COG3437	response regulator, receiver
HCG51_12050	COG3850	Histidine kinase
HCG51_12050	COG2205	protein histidine kinase activity
HCG51_12055	COG0454	-acetyltransferase
HCG51_12070	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HCG51_12075	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HCG51_12080	COG0022	dehydrogenase e1 component
HCG51_12080	COG0508	dehydrogenase complex catalyzes the overall conversion of
HCG51_12090	COG0113	porphobilinogen synthase activity
HCG51_12100	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
HCG51_12125	COG0745	RESPONSE REGULATOR receiver
HCG51_12130	COG5002	protein histidine kinase activity
HCG51_12135	COG0438	transferase activity, transferring glycosyl groups
HCG51_12190	COG0438	transferase activity, transferring glycosyl groups
HCG51_12225	COG0217	transcriptional regulatory protein
HCG51_12235	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HCG51_12240	COG2205	protein histidine kinase activity
HCG51_12240	COG0784	Response regulator, receiver
HCG51_12250	COG0741	lytic transglycosylase activity
HCG51_12255	COG0805	protein transport
HCG51_12260	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HCG51_12265	COG3001	Fructosamine kinase
HCG51_12270	COG0612	Peptidase, M16
HCG51_12305	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
HCG51_12320	COG0589	response to stress
HCG51_12325	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
HCG51_12330	COG0268	Binds directly to 16S ribosomal RNA
HCG51_12335	COG0084	hydrolase, TatD family'
HCG51_12340	COG0085	RNA polymerase activity
HCG51_12345	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
HCG51_12350	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
HCG51_12365	COG1361	Conserved repeat domain
HCG51_12370	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HCG51_12380	COG0596	Alpha beta hydrolase
HCG51_12400	COG4251	negative regulation of phosphorylation
HCG51_12410	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HCG51_12415	COG2202	Pas domain
HCG51_12415	COG2205	protein histidine kinase activity
HCG51_12425	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
HCG51_12435	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HCG51_12440	COG3654	unkown
HCG51_12465	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HCG51_12485	COG0017	Asparaginyl-tRNA synthetase
HCG51_12495	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
HCG51_12510	COG3903	Transcriptional regulator
HCG51_12510	COG2319	Wd-40 repeat
HCG51_12515	COG0589	response to stress
HCG51_12520	COG0126	phosphoglycerate kinase activity
HCG51_12550	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
HCG51_12555	COG0572	uridine kinase
HCG51_12560	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
HCG51_12595	COG2197	response regulator
HCG51_12600	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HCG51_12610	COG0840	transmembrane signaling receptor activity
HCG51_12610	COG2203	Gaf domain
HCG51_12630	COG2831	hemolysin activation secretion protein
HCG51_12675	COG5002	protein histidine kinase activity
HCG51_12690	COG0390	transport system, permease component
HCG51_12715	COG0824	Thioesterase
HCG51_12745	COG0501	Belongs to the peptidase M48B family
HCG51_12755	COG0656	L-ascorbic acid biosynthetic process
HCG51_12795	COG1836	PFAM Integral membrane protein DUF92
HCG51_12805	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
HCG51_12820	COG1385	rRNA (uridine-N3-)-methyltransferase activity
HCG51_12825	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HCG51_12865	COG0724	RNA recognition motif
HCG51_12880	COG0671	phosphoesterase, PA-phosphatase related
HCG51_12885	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
HCG51_12885	COG0456	acetyltransferase
HCG51_12900	COG3958	Transketolase
HCG51_12930	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HCG51_12935	COG0406	alpha-ribazole phosphatase activity
HCG51_12945	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HCG51_12955	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
HCG51_12970	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
HCG51_13010	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HCG51_13015	COG0288	reversible hydration of carbon dioxide
HCG51_13020	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HCG51_13065	COG1619	proteins homologs of microcin C7 resistance protein MccF
HCG51_13070	COG4310	Domain of unknown function (DUF2172)
HCG51_13075	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
HCG51_13090	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
HCG51_13110	COG0495	leucyl-tRNA aminoacylation
HCG51_13125	COG1595	DNA-templated transcription, initiation
HCG51_13135	COG1376	ErfK ybiS ycfS ynhG family protein
HCG51_13155	COG1136	(ABC) transporter
HCG51_13155	COG0577	efflux transmembrane transporter activity
HCG51_13185	COG1606	tRNA processing
HCG51_13195	COG4999	Histidine kinase
HCG51_13195	COG3850	Histidine kinase
HCG51_13195	COG2205	protein histidine kinase activity
HCG51_13195	COG3437	response regulator, receiver
HCG51_13210	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
HCG51_13215	COG0745	RESPONSE REGULATOR receiver
HCG51_13220	COG2815	serine threonine protein kinase
HCG51_13220	COG0515	serine threonine protein kinase
HCG51_13230	COG2205	protein histidine kinase activity
HCG51_13230	COG0784	Response regulator, receiver
HCG51_13230	COG2198	Histidine kinase
HCG51_13245	COG1007	ATP synthesis coupled electron transport
HCG51_13255	COG0395	ABC-type sugar transport system, permease component
HCG51_13265	COG2010	Cytochrome c
HCG51_13270	COG2010	Cytochrome c
HCG51_13275	COG3794	PFAM blue (type 1) copper domain protein
HCG51_13280	COG0297	glycogen (starch) synthase activity
HCG51_13290	COG1357	PFAM Pentapeptide repeats (8 copies)
HCG51_13290	COG0515	serine threonine protein kinase
HCG51_13300	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HCG51_13305	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HCG51_13335	COG0456	acetyltransferase
HCG51_13340	COG1063	alcohol dehydrogenase
HCG51_13345	COG0306	phosphate transporter
HCG51_13350	COG0697	spore germination
HCG51_13360	COG0784	Response regulator, receiver
HCG51_13360	COG2205	protein histidine kinase activity
HCG51_13370	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
HCG51_13375	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
HCG51_13380	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
HCG51_13400	COG1295	ribonuclease BN
HCG51_13425	COG4251	negative regulation of phosphorylation
HCG51_13425	COG3706	GGDEF domain
HCG51_13425	COG5001	Diguanylate cyclase
HCG51_13425	COG2203	Gaf domain
HCG51_13430	COG2205	protein histidine kinase activity
HCG51_13455	COG3240	lipase activity
HCG51_13485	COG1361	Conserved repeat domain
HCG51_13505	COG3266	domain, Protein
HCG51_13505	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
HCG51_13520	COG0195	Participates in both transcription termination and antitermination
HCG51_13525	COG0779	Required for maturation of 30S ribosomal subunits
HCG51_13570	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
HCG51_13600	COG0517	IMP dehydrogenase activity
HCG51_13600	COG0516	GMP reductase activity
HCG51_13605	COG0494	nUDIX hydrolase
HCG51_13615	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HCG51_13620	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
HCG51_13625	COG0783	Belongs to the Dps family
HCG51_13650	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
HCG51_13690	COG0251	oxidation-reduction process
HCG51_13700	COG1640	4-alpha-glucanotransferase
HCG51_13705	COG1426	Protein conserved in bacteria
HCG51_13710	COG1187	pseudouridine synthase activity
HCG51_13720	COG0575	Belongs to the CDS family
HCG51_13730	COG3266	domain, Protein
HCG51_13730	COG0515	serine threonine protein kinase
HCG51_13745	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HCG51_13750	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HCG51_13750	COG0189	ligase activity
HCG51_13755	COG4242	Belongs to the peptidase S51 family
HCG51_13765	COG0336	Belongs to the RNA methyltransferase TrmD family
HCG51_13770	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
HCG51_13775	COG4166	transmembrane transport
HCG51_13780	COG1691	(AIR) carboxylase
HCG51_13790	COG0165	Argininosuccinate lyase
HCG51_13810	COG0025	NhaP-type Na H and K H
HCG51_13825	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
HCG51_13830	COG0426	domain, Protein
HCG51_13830	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HCG51_13835	COG0426	domain, Protein
HCG51_13835	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HCG51_13840	COG0724	RNA recognition motif
HCG51_13860	COG1215	transferase activity, transferring glycosyl groups
HCG51_13865	COG0335	large ribosomal subunit rRNA binding
HCG51_13875	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HCG51_13880	COG0250	Participates in transcription elongation, termination and antitermination
HCG51_13885	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
HCG51_13890	COG0081	regulation of translation
HCG51_13895	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
HCG51_13900	COG0222	ribosome binding
HCG51_13910	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HCG51_13915	COG0431	NADPH-dependent FMN reductase
HCG51_13930	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
HCG51_13940	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HCG51_13945	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
HCG51_13950	COG0321	lipoyl(octanoyl) transferase activity
HCG51_13970	COG1126	abc transporter atp-binding protein
HCG51_13980	COG2319	Wd-40 repeat
HCG51_13980	COG3903	Transcriptional regulator
HCG51_13985	COG0515	serine threonine protein kinase
HCG51_13985	COG2815	serine threonine protein kinase
HCG51_14015	COG1846	Transcriptional regulator
HCG51_14030	COG0612	Peptidase, M16
HCG51_14035	COG4636	protein conserved in cyanobacteria
HCG51_14055	COG1505	serine-type exopeptidase activity
HCG51_14060	COG0643	Histidine kinase
HCG51_14060	COG2198	Histidine kinase
HCG51_14060	COG0784	Response regulator, receiver
HCG51_14095	COG0037	tRNA processing
HCG51_14110	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
HCG51_14115	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
HCG51_14120	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
HCG51_14160	COG0438	transferase activity, transferring glycosyl groups
HCG51_14170	COG1181	Belongs to the D-alanine--D-alanine ligase family
HCG51_14180	COG0583	DNA-binding transcription factor activity
HCG51_14195	COG1028	Short-chain dehydrogenase reductase Sdr
HCG51_14200	COG1773	rubredoxin
HCG51_14215	COG1649	PFAM Uncharacterised BCR, COG1649
HCG51_14220	COG2815	serine threonine protein kinase
HCG51_14220	COG0515	serine threonine protein kinase
HCG51_14225	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
HCG51_14240	COG0792	nuclease activity
HCG51_14250	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
HCG51_14290	COG0569	domain protein
HCG51_14300	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HCG51_14305	COG2226	methyltransferase
HCG51_14310	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
HCG51_14330	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
HCG51_14335	COG0237	dephospho-CoA kinase activity
HCG51_14350	COG0312	modulator of DNA gyrase
HCG51_14370	COG0484	heat shock protein binding
HCG51_14375	COG0740	serine-type endopeptidase activity
HCG51_14380	COG0740	serine-type endopeptidase activity
HCG51_14385	COG2304	oxidoreductase activity
HCG51_14390	COG2304	oxidoreductase activity
HCG51_14395	COG0346	lactoylglutathione lyase activity
HCG51_14405	COG4956	integral membrane protein (PIN domain superfamily)
HCG51_14410	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HCG51_14440	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
HCG51_14470	COG0489	protein tyrosine kinase activity
HCG51_14495	COG0438	transferase activity, transferring glycosyl groups
HCG51_14500	COG0438	transferase activity, transferring glycosyl groups
HCG51_14510	COG1215	transferase activity, transferring glycosyl groups
HCG51_14515	COG1442	glycosyl transferase family 8
HCG51_14520	COG0463	Glycosyl transferase, family 2
HCG51_14530	COG2244	polysaccharide biosynthetic process
HCG51_14535	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
HCG51_14555	COG0501	Belongs to the peptidase M48B family
HCG51_14560	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
HCG51_14570	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HCG51_14585	COG3033	Beta-eliminating lyase
HCG51_14605	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HCG51_14615	COG5002	protein histidine kinase activity
HCG51_14645	COG1943	Transposase
HCG51_14650	COG2161	toxin-antitoxin pair type II binding
HCG51_14660	COG4249	Peptidase C14 caspase catalytic subunit p20
HCG51_14660	COG2319	Wd-40 repeat
HCG51_14675	COG0436	Aminotransferase
HCG51_14680	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
HCG51_14685	COG2124	cytochrome p450
HCG51_14710	COG3852	Histidine kinase
HCG51_14720	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HCG51_14730	COG1982	Orn Lys Arg decarboxylase major
HCG51_14735	COG0644	oxidoreductase
HCG51_14745	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
HCG51_14750	COG1555	photosystem II stabilization
HCG51_14755	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
HCG51_14775	COG0515	serine threonine protein kinase
HCG51_14785	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
HCG51_14810	COG4243	Vitamin k epoxide reductase
HCG51_14815	COG0434	BtpA family
HCG51_14820	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HCG51_14825	COG0513	Belongs to the DEAD box helicase family
HCG51_14835	COG0443	Heat shock 70 kDa protein
HCG51_14840	COG4689	acetoacetate decarboxylase
HCG51_14845	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HCG51_14850	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
HCG51_14870	COG0768	penicillin binding
HCG51_14875	COG0802	atpase or kinase
HCG51_14880	COG0391	Required for morphogenesis under gluconeogenic growth conditions
HCG51_14885	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
HCG51_14890	COG0646	methionine synthase
HCG51_14890	COG1410	methionine synthase
HCG51_14905	COG0528	UMP kinase activity
HCG51_14910	COG0233	cytoplasmic translational termination
HCG51_14925	COG0398	Pfam SNARE associated Golgi protein
HCG51_14930	COG0463	Glycosyl transferase, family 2
HCG51_14960	COG0411	ABC transporter
HCG51_14985	COG0837	glucose binding
HCG51_15000	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HCG51_15005	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HCG51_15010	COG3118	belongs to the thioredoxin family
HCG51_15020	COG0583	DNA-binding transcription factor activity
HCG51_15025	COG0515	serine threonine protein kinase
HCG51_15035	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
HCG51_15040	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HCG51_15050	COG0561	phosphatase activity
HCG51_15060	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HCG51_15060	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HCG51_15085	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HCG51_15090	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HCG51_15115	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
HCG51_15130	COG0745	RESPONSE REGULATOR receiver
HCG51_15135	COG5002	protein histidine kinase activity
HCG51_15140	COG0704	Plays a role in the regulation of phosphate uptake
HCG51_15145	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HCG51_15150	COG3659	wide pore channel activity
HCG51_15165	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
HCG51_15165	COG1215	transferase activity, transferring glycosyl groups
HCG51_15175	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
HCG51_15205	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HCG51_15210	COG2226	methyltransferase
HCG51_15215	COG1690	Belongs to the RtcB family
HCG51_15220	COG2201	protein-glutamate methylesterase activity
HCG51_15225	COG0385	Bile acid
HCG51_15230	COG0667	Aldo Keto reductase
HCG51_15245	COG1899	peptidyl-lysine modification to peptidyl-hypusine
HCG51_15250	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HCG51_15270	COG2124	cytochrome p450
HCG51_15285	COG0586	Pfam SNARE associated Golgi protein
HCG51_15310	COG5592	hemerythrin HHE cation binding domain
HCG51_15325	COG1473	amidohydrolase
HCG51_15340	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
HCG51_15355	COG1028	Short-chain dehydrogenase reductase Sdr
HCG51_15365	COG1247	-acetyltransferase
HCG51_15380	COG2205	protein histidine kinase activity
HCG51_15400	COG1132	(ABC) transporter
HCG51_15435	COG2501	S4 domain
HCG51_15450	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HCG51_15455	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
HCG51_15470	COG5002	protein histidine kinase activity
HCG51_15480	COG1442	glycosyl transferase family 8
HCG51_15480	COG1216	Glycosyl transferase, family 2
HCG51_15485	COG1216	Glycosyl transferase, family 2
HCG51_15485	COG1442	glycosyl transferase family 8
HCG51_15520	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HCG51_15525	COG5002	protein histidine kinase activity
HCG51_15525	COG2198	Histidine kinase
HCG51_15525	COG0784	Response regulator, receiver
HCG51_15550	COG0489	protein tyrosine kinase activity
HCG51_15615	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HCG51_15635	COG0438	transferase activity, transferring glycosyl groups
HCG51_15650	COG0463	Glycosyl transferase, family 2
HCG51_15660	COG0297	glycogen (starch) synthase activity
HCG51_15660	COG0438	transferase activity, transferring glycosyl groups
HCG51_15670	COG0438	transferase activity, transferring glycosyl groups
HCG51_15695	COG0110	maltose O-acetyltransferase activity
HCG51_15710	COG0463	Glycosyl transferase, family 2
HCG51_15720	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HCG51_15730	COG4294	response to UV
HCG51_15735	COG0443	Heat shock 70 kDa protein
HCG51_15750	COG2162	N-hydroxyarylamine O-acetyltransferase activity
HCG51_15770	COG1819	glycosyl
HCG51_15815	COG0667	Aldo Keto reductase
HCG51_15825	COG2337	Toxic component of a toxin-antitoxin (TA) module
HCG51_15880	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
HCG51_15910	COG0583	DNA-binding transcription factor activity
HCG51_15925	COG4451	ribulose bisphosphate carboxylase, small
HCG51_15925	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
HCG51_15930	COG4576	ethanolamine utilization protein EutN carboxysome structural protein Ccml
HCG51_15935	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
HCG51_15940	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
HCG51_15945	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HCG51_15950	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HCG51_15960	COG1013	pyruvate-flavodoxin oxidoreductase activity
HCG51_15960	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
HCG51_15960	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
HCG51_15960	COG0674	pyruvate-flavodoxin oxidoreductase activity
HCG51_15990	COG2319	Wd-40 repeat
HCG51_15990	COG3903	Transcriptional regulator
HCG51_15995	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
HCG51_16010	COG4232	protein-disulfide reductase activity
HCG51_16015	COG1333	cytochrome c biogenesis protein
HCG51_16020	COG0300	oxidoreductase activity
HCG51_16070	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
HCG51_16075	COG4251	negative regulation of phosphorylation
HCG51_16085	COG2205	protein histidine kinase activity
HCG51_16090	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
HCG51_16105	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
HCG51_16110	COG0745	RESPONSE REGULATOR receiver
HCG51_16130	COG0134	indole-3-glycerol-phosphate synthase activity
HCG51_16135	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HCG51_16160	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HCG51_16175	COG0483	inositol monophosphate 1-phosphatase activity
HCG51_16180	COG0484	heat shock protein binding
HCG51_16185	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
HCG51_16190	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HCG51_16200	COG0288	reversible hydration of carbon dioxide
HCG51_16210	COG2267	carboxylic ester hydrolase activity
HCG51_16225	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HCG51_16240	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HCG51_16240	COG2205	protein histidine kinase activity
HCG51_16260	COG0562	UDP-galactopyranose mutase
HCG51_16285	COG3781	membrane
HCG51_16290	COG2234	aminopeptidase activity
HCG51_16295	COG0443	Heat shock 70 kDa protein
HCG51_16300	COG0484	heat shock protein binding
HCG51_16310	COG1598	PFAM Uncharacterised protein family UPF0150
HCG51_16335	COG0436	Aminotransferase
HCG51_16395	COG0745	RESPONSE REGULATOR receiver
HCG51_16405	COG2205	protein histidine kinase activity
HCG51_16405	COG5002	protein histidine kinase activity
HCG51_16405	COG0784	Response regulator, receiver
HCG51_16420	COG0284	orotidine-5'-phosphate decarboxylase activity
HCG51_16420	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
HCG51_16425	COG0628	permease
HCG51_16460	COG1053	succinate dehydrogenase
HCG51_16470	COG1635	Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur
HCG51_16495	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HCG51_16515	COG0542	response to heat
HCG51_16530	COG0515	serine threonine protein kinase
HCG51_16530	COG3266	domain, Protein
HCG51_16535	COG0515	serine threonine protein kinase
HCG51_16545	COG0616	signal peptide processing
HCG51_16555	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
HCG51_16570	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
HCG51_16575	COG1132	(ABC) transporter
HCG51_16600	COG0784	Response regulator, receiver
HCG51_16605	COG4251	negative regulation of phosphorylation
HCG51_16625	COG0072	phenylalanine-tRNA ligase activity
HCG51_16625	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HCG51_16650	COG2226	methyltransferase
HCG51_16675	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
HCG51_16705	COG3920	Histidine kinase
HCG51_16710	COG5002	protein histidine kinase activity
HCG51_16715	COG0788	formyltetrahydrofolate deformylase activity
HCG51_16735	COG1131	(ABC) transporter
HCG51_16795	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
HCG51_16810	COG0784	Response regulator, receiver
HCG51_16810	COG5002	protein histidine kinase activity
HCG51_16820	COG0297	glycogen (starch) synthase activity
HCG51_16825	COG0181	hydroxymethylbilane synthase activity
HCG51_16860	COG2319	Wd-40 repeat
HCG51_16860	COG1672	PFAM Archaeal ATPase
HCG51_16870	COG1803	Methylglyoxal synthase
HCG51_16870	COG1597	lipid kinase activity
HCG51_16885	COG0515	serine threonine protein kinase
HCG51_16885	COG2815	serine threonine protein kinase
HCG51_16890	COG0475	glutathione-regulated potassium exporter activity
HCG51_16930	COG5002	protein histidine kinase activity
HCG51_16940	COG1672	PFAM Archaeal ATPase
HCG51_16940	COG2319	Wd-40 repeat
HCG51_16955	COG0515	serine threonine protein kinase
HCG51_16955	COG1357	PFAM Pentapeptide repeats (8 copies)
HCG51_17005	COG0402	S-adenosylhomocysteine deaminase activity
HCG51_17010	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
HCG51_17015	COG0271	Belongs to the BolA IbaG family
HCG51_17025	COG1404	Belongs to the peptidase S8 family
HCG51_17025	COG4935	Belongs to the peptidase S8 family
HCG51_17035	COG0590	tRNA wobble adenosine to inosine editing
HCG51_17050	COG1420	regulation of RNA biosynthetic process
HCG51_17070	COG4221	oxidoreductase activity
HCG51_17080	COG0702	epimerase
HCG51_17095	COG0666	response to abiotic stimulus
HCG51_17105	COG1950	PFAM Membrane protein of
HCG51_17120	COG1797	cobyrinic acid a,c-diamide synthase activity
HCG51_17130	COG1615	UPF0182 protein
HCG51_17140	COG0052	Belongs to the universal ribosomal protein uS2 family
HCG51_17145	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
HCG51_17160	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
HCG51_17165	COG0842	Transport permease protein
HCG51_17180	COG0842	Transport permease protein
HCG51_17180	COG1129	ABC transporter
HCG51_17185	COG1131	(ABC) transporter
HCG51_17195	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HCG51_17205	COG2205	protein histidine kinase activity
HCG51_17205	COG0784	Response regulator, receiver
HCG51_17215	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
HCG51_17240	COG0012	GTP binding
HCG51_17250	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
HCG51_17270	COG0724	RNA recognition motif
HCG51_17275	COG0724	RNA recognition motif
HCG51_17285	COG3540	Alkaline phosphatase
HCG51_17300	COG3631	Ketosteroid isomerase-related protein
HCG51_17305	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
HCG51_17310	COG0546	phosphoglycolate phosphatase activity
HCG51_17325	COG1136	(ABC) transporter
HCG51_17340	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HCG51_17345	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
HCG51_17365	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HCG51_17370	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HCG51_17405	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HCG51_17410	COG2197	response regulator
HCG51_17420	COG0154	amidase activity
HCG51_17440	COG0741	lytic transglycosylase activity
HCG51_17440	COG0739	heme binding
HCG51_17440	COG1196	nuclear chromosome segregation
HCG51_17465	COG3659	wide pore channel activity
HCG51_17470	COG0725	ABC transporter, periplasmic molybdate-binding protein
HCG51_17505	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
HCG51_17510	COG0725	ABC transporter, periplasmic molybdate-binding protein
HCG51_17530	COG2366	antibiotic biosynthetic process
HCG51_17560	COG0758	DNA mediated transformation
HCG51_17560	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HCG51_17610	COG2843	Capsule synthesis protein
HCG51_17615	COG0724	RNA recognition motif
HCG51_17630	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HCG51_17630	COG1754	DNA topoisomerase type I activity
HCG51_17635	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
HCG51_17645	COG1480	7TM receptor with intracellular HD hydrolase
HCG51_17665	COG4399	Belongs to the UPF0754 family
HCG51_17670	COG2226	methyltransferase
HCG51_17675	COG2204	response regulator
HCG51_17685	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HCG51_17690	COG0581	inorganic phosphate transmembrane transporter activity
HCG51_17695	COG0573	inorganic phosphate transmembrane transporter activity
HCG51_17700	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
HCG51_17705	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HCG51_17720	COG0484	heat shock protein binding
HCG51_17725	COG0745	RESPONSE REGULATOR receiver
HCG51_17735	COG2814	Major facilitator Superfamily
HCG51_17745	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
HCG51_17755	COG0275	rRNA processing
HCG51_17825	COG3240	lipase activity
HCG51_17835	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
HCG51_17860	COG0460	homoserine dehydrogenase
HCG51_17865	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
HCG51_17875	COG0572	uridine kinase
HCG51_17880	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
HCG51_17885	COG2205	protein histidine kinase activity
HCG51_17885	COG0784	Response regulator, receiver
HCG51_17895	COG2329	Antibiotic biosynthesis monooxygenase
HCG51_17900	COG0288	reversible hydration of carbon dioxide
HCG51_17935	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HCG51_17945	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HCG51_17950	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
HCG51_17955	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
HCG51_17960	COG3977	Valine--pyruvate aminotransferase
HCG51_17965	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
HCG51_18000	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HCG51_18000	COG2022	thiamine diphosphate biosynthetic process
HCG51_18065	COG0438	transferase activity, transferring glycosyl groups
HCG51_18085	COG1216	Glycosyl transferase, family 2
HCG51_18090	COG0297	glycogen (starch) synthase activity
HCG51_18095	COG1132	(ABC) transporter
HCG51_18100	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HCG51_18105	COG0489	protein tyrosine kinase activity
HCG51_18130	COG1216	Glycosyl transferase, family 2
HCG51_18135	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HCG51_18140	COG0579	oxidoreductase
HCG51_18160	COG4245	von Willebrand factor, type A
HCG51_18175	COG3631	Ketosteroid isomerase-related protein
HCG51_18180	COG0784	Response regulator, receiver
HCG51_18180	COG2205	protein histidine kinase activity
HCG51_18180	COG5002	protein histidine kinase activity
HCG51_18215	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
HCG51_18225	COG0312	modulator of DNA gyrase
HCG51_18235	COG0215	cysteine-tRNA ligase activity
HCG51_18240	COG0523	cobalamin synthesis protein
HCG51_18245	COG1490	D-aminoacyl-tRNA deacylase activity
HCG51_18255	COG0521	Mo-molybdopterin cofactor biosynthetic process
HCG51_18260	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HCG51_18280	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
HCG51_18290	COG0039	L-malate dehydrogenase activity
HCG51_18320	COG3409	Peptidoglycan-binding domain 1 protein
HCG51_18320	COG3429	Glucose-6-phosphate dehydrogenase subunit
HCG51_18325	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
HCG51_18330	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HCG51_18335	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
HCG51_18340	COG0724	RNA recognition motif
HCG51_18360	COG0259	pyridoxamine-phosphate oxidase activity
HCG51_18365	COG1045	serine acetyltransferase
HCG51_18375	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
HCG51_18385	COG1494	fructose-1,6-bisphosphatase
HCG51_18390	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
HCG51_18400	COG4636	protein conserved in cyanobacteria
HCG51_18410	COG0640	Transcriptional regulator
HCG51_18440	COG0166	Belongs to the GPI family
HCG51_18455	COG0515	serine threonine protein kinase
HCG51_18455	COG3266	domain, Protein
HCG51_18460	COG0515	serine threonine protein kinase
HCG51_18460	COG3266	domain, Protein
HCG51_18470	COG0515	serine threonine protein kinase
HCG51_18470	COG3266	domain, Protein
HCG51_18475	COG0842	Transport permease protein
HCG51_18475	COG1131	(ABC) transporter
HCG51_18475	COG1716	ATPase activity
HCG51_18640	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
HCG51_18655	COG0515	serine threonine protein kinase
HCG51_18655	COG3266	domain, Protein
HCG51_18660	COG1902	pentaerythritol trinitrate reductase activity
HCG51_18670	COG0667	Aldo Keto reductase
HCG51_18675	COG2205	protein histidine kinase activity
HCG51_18695	COG0438	transferase activity, transferring glycosyl groups
HCG51_18710	COG0438	transferase activity, transferring glycosyl groups
HCG51_18715	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HCG51_18720	COG4249	Peptidase C14 caspase catalytic subunit p20
HCG51_18720	COG2319	Wd-40 repeat
HCG51_18750	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
HCG51_18760	COG0515	serine threonine protein kinase
HCG51_18760	COG1357	PFAM Pentapeptide repeats (8 copies)
HCG51_18765	COG1357	PFAM Pentapeptide repeats (8 copies)
HCG51_18765	COG0515	serine threonine protein kinase
HCG51_18770	COG2319	Wd-40 repeat
HCG51_18780	COG1357	PFAM Pentapeptide repeats (8 copies)
HCG51_18780	COG0515	serine threonine protein kinase
HCG51_18795	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HCG51_18805	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
HCG51_18835	COG5002	protein histidine kinase activity
HCG51_18835	COG0784	Response regulator, receiver
HCG51_18835	COG2205	protein histidine kinase activity
HCG51_18840	COG0673	inositol 2-dehydrogenase activity
HCG51_18845	COG0571	ribonuclease III activity
HCG51_18860	COG0598	Magnesium transport protein CorA
HCG51_18870	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
HCG51_18875	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HCG51_18880	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
HCG51_18890	COG0572	uridine kinase
HCG51_18905	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
HCG51_18910	COG0308	aminopeptidase N
HCG51_18920	COG2226	methyltransferase
HCG51_18935	COG0484	heat shock protein binding
HCG51_18940	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HCG51_18945	COG1959	2 iron, 2 sulfur cluster binding
HCG51_18950	COG3659	wide pore channel activity
HCG51_18955	COG2154	pterin-4-alpha-carbinolamine dehydratase
HCG51_18970	COG1122	ATPase activity
HCG51_18975	COG3688	RNA-binding protein containing a PIN domain
HCG51_18990	COG1357	PFAM Pentapeptide repeats (8 copies)
HCG51_18990	COG0515	serine threonine protein kinase
HCG51_18995	COG0697	spore germination
HCG51_19005	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
HCG51_19020	COG4771	TonB-dependent receptor
HCG51_19030	COG0784	Response regulator, receiver
HCG51_19035	COG0745	RESPONSE REGULATOR receiver
HCG51_19035	COG2205	protein histidine kinase activity
HCG51_19035	COG4191	Histidine kinase
HCG51_19050	COG2010	Cytochrome c
HCG51_19060	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HCG51_19065	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
HCG51_19080	COG3437	response regulator, receiver
HCG51_19080	COG4999	Histidine kinase
HCG51_19080	COG2205	protein histidine kinase activity
HCG51_19080	COG3850	Histidine kinase
HCG51_19090	COG0481	GTPase activity
HCG51_19105	COG1104	cysteine desulfurase activity
HCG51_19115	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HCG51_19175	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
HCG51_19190	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
HCG51_19190	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
HCG51_19195	COG0667	Aldo Keto reductase
HCG51_19200	COG4178	(ABC) transporter
HCG51_19210	COG0482	sulfurtransferase activity
HCG51_19225	COG3937	granule-associated protein
HCG51_19230	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
HCG51_19235	COG0631	protein serine/threonine phosphatase activity
HCG51_19245	COG0515	serine threonine protein kinase
HCG51_19265	COG0395	ABC-type sugar transport system, permease component
HCG51_19270	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
HCG51_19275	COG5322	oxidoreductase activity
HCG51_19280	COG0825	malonyl-CoA metabolic process
HCG51_19285	COG0300	oxidoreductase activity
HCG51_19290	COG0302	gtp cyclohydrolase
HCG51_19295	COG0135	phosphoribosylanthranilate isomerase activity
HCG51_19305	COG0517	IMP dehydrogenase activity
HCG51_19305	COG1994	Peptidase M50
HCG51_19315	COG4636	protein conserved in cyanobacteria
HCG51_19320	COG0517	IMP dehydrogenase activity
HCG51_19320	COG0617	tRNA 3'-terminal CCA addition
HCG51_19320	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
HCG51_19330	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
HCG51_19345	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
HCG51_19350	COG3239	Fatty acid desaturase
HCG51_19355	COG3239	Fatty acid desaturase
HCG51_19360	COG3239	Fatty acid desaturase
HCG51_19370	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
HCG51_19375	COG1035	Coenzyme F420 hydrogenase/dehydrogenase, beta subunit C terminus
HCG51_19380	COG0484	heat shock protein binding
HCG51_19400	COG3335	DDE superfamily endonuclease
HCG51_19405	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
HCG51_19405	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HCG51_19420	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
HCG51_19425	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
HCG51_19440	COG0133	tryptophan synthase activity
HCG51_19445	COG0023	Translation Initiation Factor
HCG51_19450	COG0401	homolog of Blt101
HCG51_19485	COG0430	RNA-3'-phosphate cyclase activity
HCG51_19490	COG0514	ATP-dependent DNA helicase (RecQ)
HCG51_19505	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
HCG51_19535	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
HCG51_19540	COG0291	Belongs to the bacterial ribosomal protein bL35 family
HCG51_19580	COG0784	Response regulator, receiver
HCG51_19585	COG3850	Histidine kinase
HCG51_19585	COG3437	response regulator, receiver
HCG51_19585	COG2205	protein histidine kinase activity
HCG51_19585	COG4999	Histidine kinase
HCG51_19590	COG2205	protein histidine kinase activity
HCG51_19595	COG0784	Response regulator, receiver
HCG51_19600	COG4251	negative regulation of phosphorylation
HCG51_19605	COG2197	response regulator
HCG51_19615	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HCG51_19620	COG2815	serine threonine protein kinase
HCG51_19620	COG0515	serine threonine protein kinase
HCG51_19640	COG0107	imidazoleglycerol-phosphate synthase activity
HCG51_19645	COG2255	four-way junction helicase activity
HCG51_19660	COG3848	Pyruvate phosphate dikinase
HCG51_19660	COG0574	Belongs to the PEP-utilizing enzyme family
HCG51_19675	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
HCG51_19680	COG1070	Carbohydrate kinase
HCG51_19705	COG1666	GTP binding
HCG51_19715	COG0857	belongs to the CobB CobQ family
HCG51_19725	COG1215	transferase activity, transferring glycosyl groups
HCG51_19730	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
HCG51_19745	COG1733	regulation of RNA biosynthetic process
HCG51_19755	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
HCG51_19790	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HCG51_19815	COG3861	electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity
HCG51_19835	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
HCG51_19845	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HCG51_19860	COG2203	Gaf domain
HCG51_19860	COG5001	Diguanylate cyclase
HCG51_19860	COG4251	negative regulation of phosphorylation
HCG51_19860	COG3706	GGDEF domain
HCG51_19875	COG0277	FAD linked oxidase domain protein
HCG51_19890	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
HCG51_19895	COG1372	Participates in initiation and elongation during chromosome replication
HCG51_19895	COG0187	DNA topoisomerase II activity
HCG51_19900	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HCG51_19905	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
HCG51_19910	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HCG51_19915	COG0784	Response regulator, receiver
HCG51_19950	COG2084	Dehydrogenase
HCG51_19970	COG2203	Gaf domain
HCG51_19975	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
HCG51_19990	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HCG51_20005	COG0596	Alpha beta hydrolase
HCG51_20010	COG1937	Protein conserved in bacteria
HCG51_20015	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HCG51_20025	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HCG51_20030	COG0577	efflux transmembrane transporter activity
HCG51_20030	COG1136	(ABC) transporter
HCG51_20035	COG1136	(ABC) transporter
HCG51_20045	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HCG51_20050	COG0577	efflux transmembrane transporter activity
HCG51_20050	COG1136	(ABC) transporter
HCG51_20075	COG0300	oxidoreductase activity
HCG51_20085	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
HCG51_20090	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HCG51_20090	COG0426	domain, Protein
HCG51_20100	COG0426	domain, Protein
HCG51_20100	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HCG51_20115	COG0649	NAD binding
HCG51_20130	COG0515	serine threonine protein kinase
HCG51_20135	COG0538	isocitrate dehydrogenase activity
HCG51_20160	COG0357	Ribosomal RNA small subunit methyltransferase G
HCG51_20165	COG1122	ATPase activity
HCG51_20215	COG1132	(ABC) transporter
HCG51_20225	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HCG51_20240	COG2234	aminopeptidase activity
HCG51_20250	COG3185	4-Hydroxyphenylpyruvate dioxygenase
HCG51_20260	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HCG51_20315	COG2169	Transcriptional regulator
HCG51_20315	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HCG51_20320	COG3621	Patatin-like phospholipase
HCG51_20345	COG1598	PFAM Uncharacterised protein family UPF0150
HCG51_20350	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
HCG51_20355	COG1253	flavin adenine dinucleotide binding
HCG51_20365	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
HCG51_20415	COG5002	protein histidine kinase activity
HCG51_20420	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
HCG51_20425	COG2201	protein-glutamate methylesterase activity
HCG51_20435	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
HCG51_20450	COG3659	wide pore channel activity
HCG51_20455	COG3659	wide pore channel activity
HCG51_20460	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
HCG51_20470	COG0129	dihydroxy-acid dehydratase activity
HCG51_20475	COG0583	DNA-binding transcription factor activity
HCG51_20485	COG2203	Gaf domain
HCG51_20485	COG5001	Diguanylate cyclase
HCG51_20485	COG4251	negative regulation of phosphorylation
HCG51_20485	COG3706	GGDEF domain
HCG51_20490	COG5002	protein histidine kinase activity
HCG51_20495	COG0784	Response regulator, receiver
HCG51_20500	COG4251	negative regulation of phosphorylation
HCG51_20515	COG0574	Belongs to the PEP-utilizing enzyme family
HCG51_20515	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HCG51_20525	COG1388	LysM domain
HCG51_20525	COG3942	CHAP domain
HCG51_20550	COG2326	polyphosphate kinase activity
HCG51_20565	COG0328	RNA-DNA hybrid ribonuclease activity
HCG51_20585	COG0211	Belongs to the bacterial ribosomal protein bL27 family
HCG51_20590	COG0261	This protein binds to 23S rRNA in the presence of protein L20
HCG51_20655	COG1215	transferase activity, transferring glycosyl groups
HCG51_20660	COG0793	Belongs to the peptidase S41A family
HCG51_20695	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
HCG51_20695	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
HCG51_20705	COG0456	acetyltransferase
HCG51_20730	COG2177	Part of the ABC transporter FtsEX involved in
HCG51_20745	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
HCG51_20755	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
HCG51_20760	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
HCG51_20765	COG0750	zinc metalloprotease
HCG51_20770	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
HCG51_20795	COG2205	protein histidine kinase activity
HCG51_20800	COG1361	Conserved repeat domain
HCG51_20820	COG0419	ATPase involved in DNA repair
HCG51_20835	COG0668	transmembrane transport
HCG51_20860	COG2321	neutral zinc metallopeptidase
HCG51_20870	COG0159	tryptophan synthase activity
HCG51_20905	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
HCG51_20910	COG0009	L-threonylcarbamoyladenylate synthase
HCG51_20920	COG0667	Aldo Keto reductase
HCG51_20925	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HCG51_20935	COG0438	transferase activity, transferring glycosyl groups
HCG51_20940	COG0010	Belongs to the arginase family
HCG51_20975	COG0793	Belongs to the peptidase S41A family
HCG51_20985	COG5002	protein histidine kinase activity
HCG51_20995	COG1022	Amp-dependent synthetase and ligase
HCG51_21040	COG2124	cytochrome p450
HCG51_21055	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
HCG51_21060	COG0003	Pfam Anion-transporting ATPase
HCG51_21090	COG0438	transferase activity, transferring glycosyl groups
HCG51_21100	COG4636	protein conserved in cyanobacteria
HCG51_21105	COG0469	pyruvate kinase activity
HCG51_21120	COG1598	PFAM Uncharacterised protein family UPF0150
HCG51_21145	COG0497	DNA recombination
HCG51_21160	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
HCG51_21215	COG1429	ligase activity, forming nitrogen-metal bonds
HCG51_21235	COG4451	ribulose bisphosphate carboxylase, small
HCG51_21245	COG1850	ribulose-bisphosphate carboxylase activity
HCG51_21255	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
HCG51_21275	COG0542	response to heat
HCG51_21300	COG1773	rubredoxin
HCG51_21305	COG2081	HI0933 family
HCG51_21310	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HCG51_21320	COG0297	glycogen (starch) synthase activity
HCG51_21325	COG3307	-O-antigen
HCG51_21330	COG0438	transferase activity, transferring glycosyl groups
HCG51_21330	COG0297	glycogen (starch) synthase activity
HCG51_21335	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
HCG51_21345	COG3507	Belongs to the glycosyl hydrolase 43 family
HCG51_21345	COG2382	esterase
HCG51_21345	COG3693	PFAM glycoside hydrolase, family 10
HCG51_21350	COG0489	protein tyrosine kinase activity
HCG51_21355	COG1361	Conserved repeat domain
HCG51_21360	COG0110	maltose O-acetyltransferase activity
HCG51_21365	COG5002	protein histidine kinase activity
HCG51_21365	COG3447	MASE1 domain protein
HCG51_21365	COG5001	Diguanylate cyclase
HCG51_21370	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
HCG51_21375	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
HCG51_21385	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
HCG51_21405	COG2814	Major facilitator Superfamily
HCG51_21410	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HCG51_21420	COG0589	response to stress
HCG51_21440	COG1028	Short-chain dehydrogenase reductase Sdr
HCG51_21450	COG1361	Conserved repeat domain
HCG51_21470	COG4948	Mandelate Racemase Muconate Lactonizing
HCG51_21510	COG1193	negative regulation of DNA recombination
HCG51_21515	COG0516	GMP reductase activity
HCG51_21520	COG3118	belongs to the thioredoxin family
HCG51_21545	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HCG51_21550	COG0204	Acyl-transferase
HCG51_21575	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
HCG51_21580	COG0416	fatty acid biosynthetic process
HCG51_21585	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HCG51_21590	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
HCG51_21600	COG0628	permease
HCG51_21615	COG1575	Belongs to the MenA family. Type 1 subfamily
HCG51_21625	COG0318	PFAM AMP-dependent synthetase and ligase
HCG51_21630	COG0824	Thioesterase
HCG51_21675	COG0811	peptide transport
HCG51_21680	COG0848	biopolymer transport protein
HCG51_21705	COG0408	coproporphyrinogen oxidase activity
HCG51_21715	COG0489	protein tyrosine kinase activity
HCG51_21720	COG0772	Belongs to the SEDS family
HCG51_21735	COG0589	response to stress
HCG51_21735	COG0475	glutathione-regulated potassium exporter activity
HCG51_21740	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HCG51_21745	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
HCG51_21760	COG1834	amidinotransferase
HCG51_21785	COG0504	CTP synthase activity
HCG51_21795	COG1940	carbohydrate kinase activity
HCG51_21805	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HCG51_21810	COG0492	ferredoxin-NADP+ reductase activity
HCG51_21820	COG4968	Prepilin-type N-terminal cleavage methylation domain
HCG51_21840	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
HCG51_21865	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HCG51_21865	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
HCG51_21870	COG0028	Belongs to the TPP enzyme family
HCG51_21870	COG4032	Thiamine pyrophosphate enzyme, N-terminal TPP binding domain
HCG51_21895	COG0515	serine threonine protein kinase
HCG51_21895	COG1357	PFAM Pentapeptide repeats (8 copies)
HCG51_21905	COG5002	protein histidine kinase activity
HCG51_21910	COG1187	pseudouridine synthase activity
HCG51_21915	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
HCG51_21925	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
HCG51_21945	COG1253	flavin adenine dinucleotide binding
HCG51_21950	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
HCG51_21955	COG0673	inositol 2-dehydrogenase activity
HCG51_21960	COG0586	Pfam SNARE associated Golgi protein
HCG51_21975	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HCG51_21980	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
HCG51_21995	COG0351	phosphomethylpyrimidine kinase
HCG51_22025	COG0584	glycerophosphoryl diester phosphodiesterase
HCG51_22030	COG0667	Aldo Keto reductase
HCG51_22035	COG1309	transcriptional regulator
HCG51_22050	COG1252	NADH dehydrogenase
HCG51_22060	COG0745	RESPONSE REGULATOR receiver
HCG51_22070	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HCG51_22075	COG0814	amino acid
HCG51_22080	COG2205	protein histidine kinase activity
HCG51_22080	COG0784	Response regulator, receiver
HCG51_22085	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HCG51_22090	COG0681	Belongs to the peptidase S26 family
HCG51_22100	COG1063	alcohol dehydrogenase
HCG51_22115	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
HCG51_22120	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
HCG51_22130	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
HCG51_22130	COG3266	domain, Protein
HCG51_22135	COG0123	including yeast histone deacetylase and acetoin utilization protein
HCG51_22145	COG0668	transmembrane transport
HCG51_22160	COG0683	leucine binding
HCG51_22165	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
HCG51_22185	COG0259	pyridoxamine-phosphate oxidase activity
HCG51_22190	COG0628	permease
HCG51_22200	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
HCG51_22205	COG1166	arginine decarboxylase activity
HCG51_22210	COG0105	UTP biosynthetic process
HCG51_22215	COG0861	Integral membrane protein TerC family
HCG51_22220	COG2267	carboxylic ester hydrolase activity
HCG51_22235	COG1672	PFAM Archaeal ATPase
HCG51_22235	COG2319	Wd-40 repeat
HCG51_22250	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HCG51_22255	COG3150	esterase
HCG51_22260	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HCG51_22295	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
HCG51_22300	COG2319	Wd-40 repeat
HCG51_22300	COG3903	Transcriptional regulator
HCG51_22315	COG0163	prenyltransferase activity
HCG51_22320	COG0557	exoribonuclease II activity
HCG51_22330	COG0740	serine-type endopeptidase activity
HCG51_22355	COG1331	Highly conserved protein containing a thioredoxin domain
HCG51_22360	COG0746	molybdenum cofactor guanylyltransferase activity
HCG51_22370	COG0672	)-iron permease
HCG51_22400	COG2132	Multicopper oxidase
HCG51_22405	COG0310	cobalt ion transport
HCG51_22415	COG1122	ATPase activity
HCG51_22435	COG2319	Wd-40 repeat
HCG51_22440	COG0574	Belongs to the PEP-utilizing enzyme family
HCG51_22440	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HCG51_22445	COG1285	pathogenesis
HCG51_22455	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
HCG51_22460	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
HCG51_22475	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HCG51_22510	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HCG51_22515	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
HCG51_22535	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
HCG51_22545	COG2131	deaminase
HCG51_22555	COG3613	nucleoside 2-deoxyribosyltransferase
HCG51_22565	COG0563	adenylate kinase activity
HCG51_22570	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
HCG51_22575	COG0363	glucosamine-6-phosphate deaminase activity
HCG51_22580	COG1716	ATPase activity
HCG51_22595	COG0222	ribosome binding
HCG51_22645	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HCG51_22660	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HCG51_22685	COG0784	Response regulator, receiver
HCG51_22685	COG2198	Histidine kinase
HCG51_22685	COG5002	protein histidine kinase activity
HCG51_22705	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
HCG51_22720	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
HCG51_22725	COG2226	methyltransferase
HCG51_22740	COG1546	Belongs to the CinA family
HCG51_22740	COG1058	Belongs to the CinA family
HCG51_22745	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HCG51_22750	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
HCG51_22765	COG0179	Fumarylacetoacetate (FAA) hydrolase
HCG51_22770	COG0360	Binds together with S18 to 16S ribosomal RNA
HCG51_22785	COG0586	Pfam SNARE associated Golgi protein
HCG51_22790	COG0137	argininosuccinate synthase activity
HCG51_22810	COG0612	Peptidase, M16
HCG51_22820	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
HCG51_22825	COG1357	PFAM Pentapeptide repeats (8 copies)
HCG51_22835	COG0678	peroxiredoxin activity
HCG51_22840	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HCG51_22850	COG3540	Alkaline phosphatase
HCG51_22865	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HCG51_22875	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
HCG51_22900	COG2197	response regulator
HCG51_22915	COG3854	ATPases associated with a variety of cellular activities
HCG51_22940	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HCG51_22960	COG0004	ammonium transporteR
HCG51_22965	COG1742	UPF0060 membrane protein
HCG51_22970	COG0004	ammonium transporteR
HCG51_22975	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
HCG51_22990	COG0589	response to stress
HCG51_22990	COG0475	glutathione-regulated potassium exporter activity
HCG51_22995	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HCG51_23005	COG2363	Small membrane protein
HCG51_23030	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
HCG51_23035	COG2894	cell division
HCG51_23040	COG0850	regulation of cytokinetic process
HCG51_23055	COG0515	serine threonine protein kinase
HCG51_23055	COG3266	domain, Protein
HCG51_23100	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HCG51_23105	COG3670	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
HCG51_23110	COG2211	Major facilitator Superfamily
HCG51_23120	COG0028	Belongs to the TPP enzyme family
HCG51_23145	COG1028	Short-chain dehydrogenase reductase Sdr
HCG51_23155	COG1028	Short-chain dehydrogenase reductase Sdr
HCG51_23170	COG4221	oxidoreductase activity
HCG51_23185	COG5000	phosphorelay sensor kinase activity
HCG51_23190	COG3852	Histidine kinase
HCG51_23195	COG3659	wide pore channel activity
HCG51_23230	COG0822	iron-sulfur transferase activity
HCG51_23255	COG3548	integral membrane protein
HCG51_23265	COG1366	Belongs to the anti-sigma-factor antagonist family
HCG51_23285	COG2208	phosphoserine phosphatase activity
HCG51_23285	COG2770	Histidine kinase
HCG51_23315	COG0243	molybdopterin cofactor binding
HCG51_23320	COG2223	nitrite transmembrane transporter activity
HCG51_23325	COG1116	anion transmembrane transporter activity
HCG51_23330	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HCG51_23330	COG1116	anion transmembrane transporter activity
HCG51_23335	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HCG51_23340	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HCG51_23390	COG3335	DDE superfamily endonuclease
HCG51_23405	COG1214	PFAM Peptidase M22, glycoprotease
HCG51_23415	COG0617	tRNA 3'-terminal CCA addition
HCG51_23425	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
HCG51_23430	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HCG51_23440	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HCG51_23450	COG0515	serine threonine protein kinase
HCG51_23455	COG0515	serine threonine protein kinase
HCG51_23470	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HCG51_23495	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HCG51_23510	COG2814	Major facilitator Superfamily
HCG51_23520	COG0525	valine-tRNA ligase activity
HCG51_23530	COG0435	Glutathione S-transferase
HCG51_23540	COG2197	response regulator
HCG51_23545	COG3842	ATPase activity
HCG51_23565	COG0629	single-stranded DNA binding
HCG51_23570	COG4172	Belongs to the ABC transporter superfamily
HCG51_23585	COG0752	glycyl-tRNA synthetase alpha subunit
HCG51_23620	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
HCG51_23625	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
HCG51_23630	COG0475	glutathione-regulated potassium exporter activity
HCG51_23630	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HCG51_23640	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
HCG51_23645	COG3852	Histidine kinase
HCG51_23650	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
HCG51_23675	COG4251	negative regulation of phosphorylation
HCG51_23675	COG2203	Gaf domain
HCG51_23675	COG3706	GGDEF domain
HCG51_23675	COG5001	Diguanylate cyclase
HCG51_23680	COG2205	protein histidine kinase activity
HCG51_23690	COG1131	(ABC) transporter
HCG51_23705	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HCG51_23715	COG1492	cobalamin metabolic process
HCG51_23730	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
HCG51_23755	COG0316	Belongs to the HesB IscA family
HCG51_23770	COG1090	epimerase
HCG51_23785	COG2217	Heavy metal translocating P-type atpase
HCG51_23860	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
HCG51_23865	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
HCG51_23885	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
HCG51_23890	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
HCG51_23895	COG0170	dolichyl monophosphate biosynthetic process
HCG51_23910	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HCG51_23910	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HCG51_23915	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
HCG51_23920	COG0148	phosphopyruvate hydratase activity
HCG51_23935	COG4802	Ferredoxin thioredoxin reductase catalytic beta chain
HCG51_23945	COG0285	dihydrofolate synthase activity
HCG51_23970	COG0612	Peptidase, M16
HCG51_23980	COG0024	Methionine aminopeptidase
HCG51_23990	COG0450	alkyl hydroperoxide reductase
HCG51_24005	COG0484	heat shock protein binding
HCG51_24015	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
HCG51_24030	COG1404	Belongs to the peptidase S8 family
HCG51_24040	COG0542	response to heat
HCG51_24055	COG0515	serine threonine protein kinase
HCG51_24060	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HCG51_24070	COG1185	polyribonucleotide nucleotidyltransferase activity
HCG51_24090	COG4372	Transposase
HCG51_24095	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HCG51_24100	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
HCG51_24105	COG0131	Imidazoleglycerol-phosphate dehydratase
HCG51_24110	COG1131	(ABC) transporter
HCG51_24115	COG1596	polysaccharide export
HCG51_24125	COG0330	HflC and HflK could
HCG51_24130	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
HCG51_24135	COG0149	triose-phosphate isomerase activity
HCG51_24140	COG1160	GTP binding
HCG51_24160	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
HCG51_24185	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HCG51_24190	COG5398	heme oxygenase
HCG51_24225	COG0693	protein deglycase activity
HCG51_24255	COG3546	catalase activity
HCG51_24275	COG1136	(ABC) transporter
HCG51_24275	COG0577	efflux transmembrane transporter activity
HCG51_24300	COG1032	radical SAM domain protein
HCG51_24310	COG0312	modulator of DNA gyrase
HCG51_24315	COG0312	modulator of DNA gyrase
HCG51_24340	COG1695	Transcriptional regulator
HCG51_24355	COG2203	Gaf domain
HCG51_24355	COG0840	transmembrane signaling receptor activity
HCG51_24360	COG5002	protein histidine kinase activity
HCG51_24400	COG0121	glutamine amidotransferase
HCG51_24420	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
HCG51_24425	COG1104	cysteine desulfurase activity
HCG51_24470	COG1085	galactose-1-phosphate uridylyltransferase
HCG51_24505	COG0798	PFAM Bile acid sodium symporter
HCG51_24510	COG0346	lactoylglutathione lyase activity
HCG51_24515	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HCG51_24520	COG1872	DUF167
HCG51_24525	COG0625	glutathione transferase activity
HCG51_24530	COG2135	peptidase activity
HCG51_24535	COG0457	Tetratricopeptide repeat
HCG51_24540	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HCG51_24545	COG0435	Glutathione S-transferase
HCG51_24565	COG1215	transferase activity, transferring glycosyl groups
HCG51_24580	COG0220	tRNA (guanine-N7-)-methyltransferase activity
HCG51_24580	COG1519	Transferase
HCG51_24595	COG3206	protein involved in exopolysaccharide biosynthesis
HCG51_24595	COG0489	protein tyrosine kinase activity
HCG51_24600	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HCG51_24610	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HCG51_24625	COG1027	Aspartate ammonia-lyase
HCG51_24630	COG2006	4fe-4S ferredoxin, iron-sulfur binding domain protein
HCG51_24645	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
HCG51_24650	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
HCG51_24660	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HCG51_24665	COG0583	DNA-binding transcription factor activity
HCG51_24675	COG0723	plastoquinol--plastocyanin reductase activity
HCG51_24685	COG3210	domain, Protein
HCG51_24690	COG1461	Dihydroxyacetone kinase
HCG51_24735	COG0322	excinuclease ABC activity
HCG51_24740	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HCG51_24745	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HCG51_24750	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HCG51_24755	COG1773	rubredoxin
HCG51_24760	COG4447	cellulose binding
HCG51_24820	COG4249	Peptidase C14 caspase catalytic subunit p20
HCG51_24820	COG2319	Wd-40 repeat
HCG51_24840	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
HCG51_24845	COG0189	ligase activity
HCG51_24850	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
HCG51_24860	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
HCG51_24870	COG0793	Belongs to the peptidase S41A family
HCG51_24875	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
HCG51_24895	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HCG51_24910	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
HCG51_24935	COG2197	response regulator
HCG51_24940	COG0170	dolichyl monophosphate biosynthetic process
HCG51_24950	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HCG51_24955	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HCG51_24960	COG0776	regulation of translation
HCG51_24965	COG1357	PFAM Pentapeptide repeats (8 copies)
HCG51_24970	COG0404	The glycine cleavage system catalyzes the degradation of glycine
HCG51_24975	COG0509	glycine decarboxylation via glycine cleavage system
HCG51_24980	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HCG51_24980	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HCG51_24985	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HCG51_25045	COG2095	MarC family integral membrane protein
HCG51_25075	COG0784	Response regulator, receiver
HCG51_25075	COG2205	protein histidine kinase activity
HCG51_25085	COG0577	efflux transmembrane transporter activity
HCG51_25085	COG1136	(ABC) transporter
HCG51_25100	COG1309	transcriptional regulator
HCG51_25105	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
HCG51_25125	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HCG51_25140	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
HCG51_25150	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HCG51_25155	COG4572	Cation transport regulator
HCG51_25160	COG2814	Major facilitator Superfamily
HCG51_25180	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
HCG51_25185	COG1233	COG1233 Phytoene dehydrogenase and related
HCG51_25190	COG3266	domain, Protein
HCG51_25190	COG0515	serine threonine protein kinase
HCG51_25225	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HCG51_25225	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
HCG51_25235	COG5002	protein histidine kinase activity
HCG51_25235	COG2198	Histidine kinase
HCG51_25235	COG0784	Response regulator, receiver
HCG51_25265	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
HCG51_25270	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
HCG51_25310	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
HCG51_25320	COG0693	protein deglycase activity
HCG51_25325	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
HCG51_25355	COG1215	transferase activity, transferring glycosyl groups
HCG51_25400	COG2046	Belongs to the sulfate adenylyltransferase family
HCG51_25465	COG0508	dehydrogenase complex catalyzes the overall conversion of
HCG51_25505	COG0659	secondary active sulfate transmembrane transporter activity
HCG51_25550	COG0175	sulfate reduction
HCG51_25560	COG0004	ammonium transporteR
HCG51_25565	COG0515	serine threonine protein kinase
HCG51_25580	COG0003	Pfam Anion-transporting ATPase
HCG51_25585	COG4251	negative regulation of phosphorylation
HCG51_25585	COG2203	Gaf domain
HCG51_25585	COG3706	GGDEF domain
HCG51_25585	COG4251	negative regulation of phosphorylation
HCG51_25585	COG5001	Diguanylate cyclase
HCG51_25585	COG5001	Diguanylate cyclase
HCG51_25585	COG2203	Gaf domain
HCG51_25585	COG3706	GGDEF domain
HCG51_25590	COG0592	DNA-directed DNA polymerase activity
HCG51_25595	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
HCG51_25610	COG0701	Predicted permease
HCG51_25615	COG3852	Histidine kinase
HCG51_25630	COG1028	Short-chain dehydrogenase reductase Sdr
HCG51_25665	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
HCG51_25670	COG2885	chlorophyll binding
HCG51_25675	COG2885	chlorophyll binding
HCG51_25685	COG2066	Belongs to the glutaminase family
HCG51_25705	COG0515	serine threonine protein kinase
HCG51_25705	COG2815	serine threonine protein kinase
HCG51_25710	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HCG51_25720	COG1151	hydroxylamine reductase activity
HCG51_25725	COG1034	ATP synthesis coupled electron transport
HCG51_25730	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HCG51_25735	COG3259	Nickel-dependent hydrogenase
HCG51_25745	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HCG51_25745	COG0045	succinate-CoA ligase (ADP-forming) activity
HCG51_25745	COG1042	CoA-binding domain protein
HCG51_25755	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HCG51_25760	COG2124	cytochrome p450
HCG51_25765	COG0515	serine threonine protein kinase
HCG51_25765	COG2815	serine threonine protein kinase
HCG51_25775	COG1489	DNA binding
HCG51_25810	COG0484	heat shock protein binding
HCG51_25820	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
HCG51_25825	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
HCG51_25830	COG0019	diaminopimelate decarboxylase activity
HCG51_25835	COG0456	acetyltransferase
HCG51_25840	COG0542	response to heat
HCG51_25860	COG0681	Belongs to the peptidase S26 family
HCG51_25885	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HCG51_25890	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
HCG51_25895	COG0284	orotidine-5'-phosphate decarboxylase activity
HCG51_25905	COG2815	serine threonine protein kinase
HCG51_25905	COG0515	serine threonine protein kinase
HCG51_25910	COG1028	Short-chain dehydrogenase reductase Sdr
HCG51_25920	COG1132	(ABC) transporter
HCG51_25925	COG1132	(ABC) transporter
HCG51_25935	COG4279	zinc finger
HCG51_25950	COG0346	lactoylglutathione lyase activity
HCG51_25955	COG0542	response to heat
HCG51_25960	COG1357	PFAM Pentapeptide repeats (8 copies)
HCG51_25960	COG0515	serine threonine protein kinase
HCG51_25980	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
HCG51_25990	COG0393	Putative heavy-metal-binding
HCG51_26035	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HCG51_26040	COG3266	domain, Protein
HCG51_26040	COG0515	serine threonine protein kinase
HCG51_26045	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
HCG51_26050	COG1473	amidohydrolase
HCG51_26060	COG2376	Dihydroxyacetone kinase
HCG51_26075	COG0625	glutathione transferase activity
HCG51_26085	COG0242	peptide deformylase activity
HCG51_26090	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HCG51_26095	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
HCG51_26115	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HCG51_26130	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HCG51_26130	COG2022	thiamine diphosphate biosynthetic process
HCG51_26140	COG1570	exodeoxyribonuclease VII activity
HCG51_26145	COG1722	exodeoxyribonuclease VII activity
HCG51_26165	COG1562	ergosterol biosynthetic process
HCG51_26170	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
HCG51_26170	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HCG51_26185	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
HCG51_26220	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
HCG51_26235	COG0438	transferase activity, transferring glycosyl groups
HCG51_26240	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HCG51_26260	COG0300	oxidoreductase activity
HCG51_26280	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
HCG51_26315	COG1028	Short-chain dehydrogenase reductase Sdr
HCG51_26345	COG1040	competence protein
HCG51_26355	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
HCG51_26375	COG0343	queuine tRNA-ribosyltransferase activity
HCG51_26395	COG0589	response to stress
HCG51_26405	COG2205	protein histidine kinase activity
HCG51_26405	COG2202	Pas domain
HCG51_26410	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
HCG51_26410	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HCG51_26425	COG0596	Alpha beta hydrolase
HCG51_26435	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HCG51_26440	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
HCG51_26450	COG0505	Belongs to the CarA family
HCG51_26460	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HCG51_26490	COG0189	ligase activity
HCG51_26490	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HCG51_26500	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
HCG51_26510	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
HCG51_26525	COG0047	phosphoribosylformylglycinamidine synthase activity
HCG51_26530	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HCG51_26535	COG0735	belongs to the Fur family
HCG51_26545	COG0330	HflC and HflK could
HCG51_26590	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
HCG51_26595	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
HCG51_26610	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
HCG51_26625	COG2226	methyltransferase
HCG51_26660	COG0784	Response regulator, receiver
HCG51_26660	COG5002	protein histidine kinase activity
HCG51_26670	COG0745	RESPONSE REGULATOR receiver
HCG51_26675	COG0643	Histidine kinase
HCG51_26675	COG2198	Histidine kinase
HCG51_26675	COG0784	Response regulator, receiver
HCG51_26700	COG2201	protein-glutamate methylesterase activity
HCG51_26740	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
HCG51_26745	COG3659	wide pore channel activity
HCG51_26755	COG0525	valine-tRNA ligase activity
HCG51_26765	COG2814	Major facilitator Superfamily
HCG51_26770	COG2971	BadF BadG BcrA BcrD
HCG51_26795	COG1619	proteins homologs of microcin C7 resistance protein MccF
HCG51_26800	COG0424	maF-like protein
HCG51_26820	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
HCG51_26840	COG2264	protein methyltransferase activity
HCG51_26855	COG0463	Glycosyl transferase, family 2
HCG51_26865	COG2814	Major facilitator Superfamily
HCG51_26875	COG0315	cyclic pyranopterin monophosphate synthase activity
HCG51_26915	COG2226	methyltransferase
HCG51_26950	COG1429	ligase activity, forming nitrogen-metal bonds
HCG51_27030	COG1028	Short-chain dehydrogenase reductase Sdr
HCG51_27035	COG2264	protein methyltransferase activity
HCG51_27040	COG0531	amino acid
HCG51_27045	COG5002	protein histidine kinase activity
HCG51_27060	COG0726	polysaccharide deacetylase
HCG51_27075	COG0235	Class ii aldolase
HCG51_27080	COG4359	Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene)
HCG51_27085	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
HCG51_27100	COG3507	Belongs to the glycosyl hydrolase 43 family
HCG51_27110	COG0205	6-phosphofructokinase activity
HCG51_27140	COG2815	serine threonine protein kinase
HCG51_27140	COG0515	serine threonine protein kinase
HCG51_27145	COG0515	serine threonine protein kinase
HCG51_27145	COG2815	serine threonine protein kinase
HCG51_27165	COG0156	8-amino-7-oxononanoate synthase activity
HCG51_27170	COG0632	four-way junction helicase activity
HCG51_27175	COG0561	phosphatase activity
HCG51_27180	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HCG51_27195	COG3228	Belongs to the MtfA family
HCG51_27200	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
HCG51_27260	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
HCG51_27280	COG0513	Belongs to the DEAD box helicase family
HCG51_27285	COG1032	radical SAM domain protein
HCG51_27335	COG1598	PFAM Uncharacterised protein family UPF0150
HCG51_27350	COG2373	Large extracellular alpha-helical protein
HCG51_27355	COG4953	penicillin-binding protein 1C
HCG51_27375	COG0300	oxidoreductase activity
HCG51_27410	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
HCG51_27415	COG1408	metallophosphoesterase
HCG51_27420	COG1408	metallophosphoesterase
HCG51_27435	COG0730	response to heat
HCG51_27450	COG0445	tRNA wobble uridine modification
HCG51_27470	COG0515	serine threonine protein kinase
HCG51_27470	COG1357	PFAM Pentapeptide repeats (8 copies)
HCG51_27480	COG2149	membrane
HCG51_27495	COG0784	Response regulator, receiver
HCG51_27500	COG4251	negative regulation of phosphorylation
HCG51_27545	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
HCG51_27560	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
HCG51_27580	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
HCG51_27605	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HCG51_27620	COG5002	protein histidine kinase activity
HCG51_27625	COG2201	protein-glutamate methylesterase activity
HCG51_27630	COG0784	Response regulator, receiver
HCG51_27630	COG0643	Histidine kinase
HCG51_27630	COG2198	Histidine kinase
HCG51_27630	COG0643	Histidine kinase
HCG51_27630	COG0784	Response regulator, receiver
HCG51_27630	COG2198	Histidine kinase
HCG51_27640	COG0840	transmembrane signaling receptor activity
HCG51_27665	COG1252	NADH dehydrogenase
HCG51_27685	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
HCG51_27705	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HCG51_27710	COG0395	ABC-type sugar transport system, permease component
HCG51_27720	COG0303	'Molybdopterin
HCG51_27730	COG0267	Belongs to the bacterial ribosomal protein bL33 family
HCG51_27735	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
HCG51_27740	COG0557	exoribonuclease II activity
HCG51_27795	COG1672	PFAM Archaeal ATPase
HCG51_27795	COG2319	Wd-40 repeat
HCG51_27830	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HCG51_27850	COG4585	Histidine kinase
HCG51_27855	COG2197	response regulator
HCG51_27870	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HCG51_27890	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
HCG51_27890	COG2273	Hydrolase Family 16
HCG51_27895	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HCG51_27910	COG0363	glucosamine-6-phosphate deaminase activity
HCG51_27935	COG0492	ferredoxin-NADP+ reductase activity
HCG51_27940	COG0300	oxidoreductase activity
HCG51_27950	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HCG51_27955	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HCG51_27965	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HCG51_27995	COG0220	tRNA (guanine-N7-)-methyltransferase activity
HCG51_28000	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
HCG51_28025	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
HCG51_28030	COG0518	GMP synthase (glutamine-hydrolyzing) activity
HCG51_28030	COG0519	Catalyzes the synthesis of GMP from XMP
HCG51_28035	COG1230	cation diffusion facilitator family transporter
HCG51_28050	COG0436	Aminotransferase
HCG51_28055	COG0463	Glycosyl transferase, family 2
HCG51_28055	COG0457	Tetratricopeptide repeat
HCG51_28080	COG0745	RESPONSE REGULATOR receiver
HCG51_28095	COG0606	chelatase, subunit chli
HCG51_28100	COG0537	adenosine 5'-monophosphoramidase activity
HCG51_28105	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
HCG51_28110	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
HCG51_28115	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HCG51_28120	COG0735	belongs to the Fur family
HCG51_28135	COG2205	protein histidine kinase activity
HCG51_28135	COG2202	Pas domain
HCG51_28140	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
HCG51_28145	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
HCG51_28160	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HCG51_28170	COG2261	transglycosylase associated protein
HCG51_28175	COG3237	CsbD-like
HCG51_28190	COG4572	Cation transport regulator
HCG51_28195	COG0783	Belongs to the Dps family
HCG51_28220	COG0784	Response regulator, receiver
HCG51_28220	COG2205	protein histidine kinase activity
HCG51_28220	COG5002	protein histidine kinase activity
HCG51_28255	COG0653	protein targeting
HCG51_28285	COG3852	Histidine kinase
HCG51_28290	COG0820	rRNA (adenine-C2-)-methyltransferase activity
HCG51_28300	COG0322	excinuclease ABC activity
HCG51_28310	COG0436	Aminotransferase
HCG51_28315	COG3118	belongs to the thioredoxin family
HCG51_28320	COG1842	Phage shock protein A
HCG51_28325	COG1842	Phage shock protein A
HCG51_28390	COG0124	histidyl-tRNA synthetase
HCG51_28400	COG0251	oxidation-reduction process
HCG51_28410	COG3246	L-lysine catabolic process to acetate
HCG51_28430	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HCG51_28480	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HCG51_28495	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HCG51_28500	COG1960	acyl-CoA dehydrogenase activity
HCG51_28505	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
HCG51_28510	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
HCG51_28525	COG4251	negative regulation of phosphorylation
HCG51_28530	COG3437	response regulator, receiver
HCG51_28530	COG2205	protein histidine kinase activity
HCG51_28530	COG3850	Histidine kinase
HCG51_28530	COG4999	Histidine kinase
HCG51_28535	COG2815	serine threonine protein kinase
HCG51_28535	COG0515	serine threonine protein kinase
HCG51_28555	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
HCG51_28565	COG0018	arginyl-trna synthetase
HCG51_28585	COG0438	transferase activity, transferring glycosyl groups
HCG51_28615	COG3852	Histidine kinase
HCG51_28625	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
HCG51_28665	COG3344	reverse transcriptase
HCG51_28670	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
HCG51_28740	COG1262	PFAM Formylglycine-generating sulfatase enzyme
HCG51_28740	COG0515	serine threonine protein kinase
HCG51_28760	COG2205	protein histidine kinase activity
HCG51_28760	COG0784	Response regulator, receiver
HCG51_28770	COG3000	fatty acid hydroxylase
HCG51_28770	COG0300	oxidoreductase activity
HCG51_28785	COG0714	Associated with various cellular activities
HCG51_28790	COG3552	Protein containing von Willebrand factor type A (VWA) domain
HCG51_28810	COG2261	transglycosylase associated protein
HCG51_28815	COG3546	catalase activity
HCG51_28870	COG4636	protein conserved in cyanobacteria
HCG51_28890	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
HCG51_28895	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
HCG51_28900	COG0742	ribosomal rna small subunit methyltransferase
HCG51_28910	COG2010	Cytochrome c
HCG51_28930	COG1132	(ABC) transporter
HCG51_28945	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HCG51_28950	COG0719	Fe-S assembly protein
HCG51_28955	COG0396	ATPase activity
HCG51_28960	COG0719	Fe-S assembly protein
HCG51_28980	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HCG51_28990	COG2197	response regulator
HCG51_29005	COG0439	Biotin carboxylase
HCG51_29010	COG0762	integral membrane protein
HCG51_29020	COG0515	serine threonine protein kinase
HCG51_29060	COG0227	Belongs to the bacterial ribosomal protein bL28 family
HCG51_29090	COG0463	Glycosyl transferase, family 2
HCG51_29095	COG1216	Glycosyl transferase, family 2
HCG51_29100	COG0463	Glycosyl transferase, family 2
HCG51_29100	COG1216	Glycosyl transferase, family 2
HCG51_29270	COG3621	Patatin-like phospholipase
HCG51_29285	COG2197	response regulator
HCG51_29295	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HCG51_29295	COG2205	protein histidine kinase activity
HCG51_29300	COG0828	Belongs to the bacterial ribosomal protein bS21 family
HCG51_29305	COG0193	aminoacyl-tRNA hydrolase activity
HCG51_29310	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HCG51_29335	COG0514	ATP-dependent DNA helicase (RecQ)
HCG51_29345	COG2208	phosphoserine phosphatase activity
HCG51_29350	COG0552	protein localization to endoplasmic reticulum
HCG51_29355	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HCG51_29375	COG0714	Associated with various cellular activities
HCG51_29400	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
HCG51_29480	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HCG51_29485	COG0174	glutamine synthetase
HCG51_29500	COG1252	NADH dehydrogenase
HCG51_29510	COG1957	nucleoside hydrolase
HCG51_29520	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HCG51_29545	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HCG51_29550	COG0110	maltose O-acetyltransferase activity
HCG51_29595	COG4231	catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates
HCG51_29640	COG1262	PFAM Formylglycine-generating sulfatase enzyme
HCG51_29640	COG0515	serine threonine protein kinase
HCG51_29655	COG0515	serine threonine protein kinase
HCG51_29655	COG1262	PFAM Formylglycine-generating sulfatase enzyme
HCG51_29665	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HCG51_29690	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HCG51_29700	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HCG51_29730	COG0210	DNA helicase
HCG51_29735	COG4251	negative regulation of phosphorylation
HCG51_29735	COG3706	GGDEF domain
HCG51_29735	COG2203	Gaf domain
HCG51_29735	COG5001	Diguanylate cyclase
HCG51_29755	COG0723	plastoquinol--plastocyanin reductase activity
HCG51_29765	COG0673	inositol 2-dehydrogenase activity
HCG51_29830	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HCG51_29835	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
HCG51_29845	COG0110	maltose O-acetyltransferase activity
HCG51_29860	COG0463	Glycosyl transferase, family 2
HCG51_29865	COG0438	transferase activity, transferring glycosyl groups
HCG51_29880	COG0438	transferase activity, transferring glycosyl groups
HCG51_29885	COG0367	asparagine synthase
HCG51_29890	COG0297	glycogen (starch) synthase activity
HCG51_29910	COG0438	transferase activity, transferring glycosyl groups
HCG51_29920	COG0297	glycogen (starch) synthase activity
HCG51_29930	COG0438	transferase activity, transferring glycosyl groups
HCG51_29935	COG1215	transferase activity, transferring glycosyl groups
HCG51_29940	COG0438	transferase activity, transferring glycosyl groups
HCG51_29960	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HCG51_29965	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HCG51_29985	COG0673	inositol 2-dehydrogenase activity
HCG51_30030	COG0489	protein tyrosine kinase activity
HCG51_30070	COG1672	PFAM Archaeal ATPase
HCG51_30070	COG2319	Wd-40 repeat
HCG51_30120	COG3788	relative of glutathione S-transferase, MAPEG superfamily
HCG51_30145	COG0848	biopolymer transport protein
HCG51_30150	COG0811	peptide transport
HCG51_30185	COG5002	protein histidine kinase activity
HCG51_30250	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HCG51_30320	COG0728	peptidoglycan biosynthetic process
HCG51_30330	COG1357	PFAM Pentapeptide repeats (8 copies)
HCG51_30335	COG1316	TRANSCRIPTIONal
HCG51_30345	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
HCG51_30360	COG2326	polyphosphate kinase activity
HCG51_30365	COG0574	Belongs to the PEP-utilizing enzyme family
HCG51_30365	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HCG51_30370	COG0589	response to stress
HCG51_30375	COG0469	pyruvate kinase activity
HCG51_30425	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
HCG51_30430	COG0088	Forms part of the polypeptide exit tunnel
HCG51_30435	COG0089	rRNA binding
HCG51_30440	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
HCG51_30445	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
HCG51_30450	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
HCG51_30455	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
HCG51_30465	COG0255	Belongs to the universal ribosomal protein uL29 family
HCG51_30470	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
HCG51_30475	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
HCG51_30480	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
HCG51_30485	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
HCG51_30490	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
HCG51_30495	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
HCG51_30500	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
HCG51_30505	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
HCG51_30510	COG0200	Binds to the 23S rRNA
HCG51_30515	COG0201	protein transport
HCG51_30520	COG0563	adenylate kinase activity
HCG51_30525	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
HCG51_30530	COG0257	Belongs to the bacterial ribosomal protein bL36 family
HCG51_30535	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
HCG51_30540	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
HCG51_30545	COG0202	RNA polymerase activity
HCG51_30550	COG0203	ribosomal protein L17
HCG51_30555	COG0101	tRNA pseudouridine synthase activity
HCG51_30565	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
HCG51_30570	COG0254	rRNA binding
HCG51_30575	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
HCG51_30590	COG0488	(ABC) transporter
HCG51_30595	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
HCG51_30625	COG0438	transferase activity, transferring glycosyl groups
HCG51_30635	COG1381	Involved in DNA repair and RecF pathway recombination
HCG51_30640	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
HCG51_30675	COG0799	negative regulation of ribosome biogenesis
HCG51_30680	COG0297	glycogen (starch) synthase activity
HCG51_30685	COG1126	abc transporter atp-binding protein
HCG51_30690	COG0765	amino acid transport
HCG51_30695	COG4597	amino acid ABC transporter
HCG51_30700	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HCG51_30715	COG0602	queuosine metabolic process
HCG51_30755	COG1049	propionate catabolic process, 2-methylcitrate cycle
HCG51_30760	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HCG51_30770	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HCG51_30785	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
HCG51_30845	COG0438	transferase activity, transferring glycosyl groups
HCG51_30855	COG1215	transferase activity, transferring glycosyl groups
HCG51_30865	COG0438	transferase activity, transferring glycosyl groups
HCG51_30875	COG1192	Involved in chromosome partitioning
HCG51_30880	COG1192	Involved in chromosome partitioning
HCG51_30885	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
HCG51_30895	COG0180	Tryptophanyl-tRNA synthetase
HCG51_30945	COG1968	undecaprenyl-diphosphatase activity
HCG51_30965	COG5001	Diguanylate cyclase
HCG51_30985	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
HCG51_30985	COG0662	Cupin 2, conserved barrel domain protein
HCG51_30990	COG1032	radical SAM domain protein
HCG51_31010	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
HCG51_31030	COG1215	transferase activity, transferring glycosyl groups
HCG51_31050	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
HCG51_31065	COG1301	dicarboxylic acid transport
HCG51_31070	COG0587	DNA-directed DNA polymerase activity
HCG51_31090	COG1028	Short-chain dehydrogenase reductase Sdr
HCG51_31105	COG0640	Transcriptional regulator
HCG51_31110	COG3118	belongs to the thioredoxin family
HCG51_31125	COG0625	glutathione transferase activity
HCG51_31150	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
HCG51_31155	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
HCG51_31160	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HCG51_31165	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
HCG51_31175	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HCG51_31180	COG0356	it plays a direct role in the translocation of protons across the membrane
HCG51_31195	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HCG51_31220	COG0297	glycogen (starch) synthase activity
HCG51_31250	COG0772	Belongs to the SEDS family
HCG51_31315	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
HCG51_31335	COG0459	protein refolding
HCG51_31350	COG1028	Short-chain dehydrogenase reductase Sdr
HCG51_31365	COG1012	belongs to the aldehyde dehydrogenase family
HCG51_31390	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HCG51_31400	COG0415	Belongs to the DNA photolyase family
HCG51_31410	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
HCG51_31415	COG0830	nickel cation binding
HCG51_31420	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
HCG51_31425	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
HCG51_31445	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
HCG51_31450	COG3536	Protein conserved in bacteria
HCG51_31460	COG0138	bifunctional purine biosynthesis protein purh
HCG51_31510	COG4249	Peptidase C14 caspase catalytic subunit p20
HCG51_31510	COG2319	Wd-40 repeat
HCG51_31535	COG2319	Wd-40 repeat
HCG51_31535	COG5635	Nacht domain
HCG51_31535	COG2319	Wd-40 repeat
HCG51_31535	COG5635	Nacht domain
HCG51_31545	COG1672	PFAM Archaeal ATPase
HCG51_31545	COG2319	Wd-40 repeat
HCG51_31575	COG0739	heme binding
HCG51_31585	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
HCG51_31595	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
HCG51_31605	COG1285	pathogenesis
HCG51_31650	COG0475	glutathione-regulated potassium exporter activity
HCG51_31655	COG0475	glutathione-regulated potassium exporter activity
HCG51_31685	COG2217	Heavy metal translocating P-type atpase
HCG51_31750	COG1116	anion transmembrane transporter activity
HCG51_31755	COG1116	anion transmembrane transporter activity
HCG51_31755	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HCG51_31760	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HCG51_31765	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HCG51_31795	COG0515	serine threonine protein kinase
HCG51_31795	COG3266	domain, Protein
HCG51_31805	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
HCG51_31840	COG0438	transferase activity, transferring glycosyl groups
HCG51_31845	COG2045	Belongs to the ComB family
HCG51_31890	COG2091	lysine biosynthetic process via aminoadipic acid
HCG51_31900	COG0429	hydrolase of the alpha beta-hydrolase fold
HCG51_31905	COG0745	RESPONSE REGULATOR receiver
HCG51_31910	COG0793	Belongs to the peptidase S41A family
HCG51_31915	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
HCG51_31920	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
HCG51_31930	COG0438	transferase activity, transferring glycosyl groups
HCG51_31940	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
HCG51_31945	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
HCG51_31950	COG1959	2 iron, 2 sulfur cluster binding
HCG51_31960	COG0038	chloride channel
HCG51_31970	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
HCG51_32005	COG0745	RESPONSE REGULATOR receiver
HCG51_32010	COG5002	protein histidine kinase activity
HCG51_32010	COG2205	protein histidine kinase activity
HCG51_32010	COG0784	Response regulator, receiver
HCG51_32060	COG0375	protein maturation
HCG51_32065	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
HCG51_32090	COG4106	trans-aconitate 2-methyltransferase activity
HCG51_32120	COG2885	chlorophyll binding
HCG51_32210	COG2202	Pas domain
HCG51_32210	COG2205	protein histidine kinase activity
HCG51_32270	COG1012	belongs to the aldehyde dehydrogenase family
HCG51_32290	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HCG51_32305	COG2217	Heavy metal translocating P-type atpase
HCG51_32315	COG2223	nitrite transmembrane transporter activity
HCG51_32335	COG0405	Gamma-glutamyltransferase
HCG51_32350	COG0667	Aldo Keto reductase
HCG51_32360	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HCG51_32365	COG1216	Glycosyl transferase, family 2
HCG51_32365	COG1442	glycosyl transferase family 8
HCG51_32370	COG2124	cytochrome p450
HCG51_32375	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
HCG51_32450	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
HCG51_32455	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HCG51_32460	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HCG51_32465	COG2048	Heterodisulfide reductase, subunit B
HCG51_32480	COG1528	Iron-storage protein
HCG51_32490	COG5002	protein histidine kinase activity
HCG51_32490	COG5001	Diguanylate cyclase
HCG51_32490	COG3447	MASE1 domain protein
HCG51_32495	COG5002	protein histidine kinase activity
HCG51_32525	COG0352	thiamine-phosphate diphosphorylase activity
HCG51_32530	COG4974	Belongs to the 'phage' integrase family
HCG51_32535	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
HCG51_32540	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
HCG51_32545	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
HCG51_32550	COG4208	sulfate ABC transporter
HCG51_32560	COG2385	sporulation resulting in formation of a cellular spore
HCG51_32595	COG2205	protein histidine kinase activity
HCG51_32595	COG4999	Histidine kinase
HCG51_32595	COG3850	Histidine kinase
HCG51_32595	COG3437	response regulator, receiver
HCG51_32605	COG4251	negative regulation of phosphorylation
HCG51_32605	COG2203	Gaf domain
HCG51_32605	COG5001	Diguanylate cyclase
HCG51_32605	COG3706	GGDEF domain
HCG51_32620	COG0828	Belongs to the bacterial ribosomal protein bS21 family
HCG51_32625	COG0724	RNA recognition motif
HCG51_32630	COG1830	Aldolase
HCG51_32635	COG4249	Peptidase C14 caspase catalytic subunit p20
HCG51_32635	COG2319	Wd-40 repeat
HCG51_32660	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
HCG51_32665	COG5398	heme oxygenase
HCG51_32670	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HCG51_32675	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
HCG51_32690	COG1028	Short-chain dehydrogenase reductase Sdr
HCG51_32695	COG1904	glucuronate isomerase
HCG51_32705	COG3265	gluconokinase activity
HCG51_32725	COG0358	DNA primase activity
HCG51_32775	COG1120	ATPase activity
HCG51_32780	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HCG51_32790	COG3659	wide pore channel activity
HCG51_32795	COG1172	Belongs to the binding-protein-dependent transport system permease family
HCG51_32800	COG1129	ABC transporter
HCG51_32805	COG1879	ABC-type sugar transport system periplasmic component
HCG51_32810	COG1879	ABC-type sugar transport system periplasmic component
HCG51_32870	COG0584	glycerophosphoryl diester phosphodiesterase
HCG51_32895	COG3708	Transcriptional regulator
HCG51_32895	COG2207	Transcriptional regulator
HCG51_32900	COG0667	Aldo Keto reductase
HCG51_32905	COG0783	Belongs to the Dps family
HCG51_32910	COG1741	Belongs to the pirin family
HCG51_32940	COG0109	protoheme IX farnesyltransferase activity
HCG51_32960	COG5002	protein histidine kinase activity
HCG51_32990	COG1116	anion transmembrane transporter activity
HCG51_32995	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HCG51_32995	COG1116	anion transmembrane transporter activity
HCG51_33000	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HCG51_33015	COG0571	ribonuclease III activity
HCG51_33035	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
HCG51_33035	COG1240	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
HCG51_33045	COG0670	Belongs to the BI1 family
HCG51_33055	COG0318	PFAM AMP-dependent synthetase and ligase
HCG51_33060	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
HCG51_33075	COG0515	serine threonine protein kinase
HCG51_33080	COG1196	nuclear chromosome segregation
HCG51_33120	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HCG51_33125	COG2274	protein secretion by the type I secretion system
HCG51_33135	COG2340	Cysteine-rich secretory protein family
HCG51_33180	COG0515	serine threonine protein kinase
HCG51_33180	COG3266	domain, Protein
HCG51_33200	COG0745	RESPONSE REGULATOR receiver
HCG51_33215	COG0783	Belongs to the Dps family
HCG51_33225	COG2385	sporulation resulting in formation of a cellular spore
HCG51_33235	COG0673	inositol 2-dehydrogenase activity
HCG51_33240	COG0024	Methionine aminopeptidase
HCG51_33280	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HCG51_33315	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HCG51_33320	COG1959	2 iron, 2 sulfur cluster binding
HCG51_33325	COG1045	serine acetyltransferase
HCG51_33335	COG0745	RESPONSE REGULATOR receiver
HCG51_33350	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
HCG51_33355	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HCG51_33360	COG0556	nucleotide-excision repair
HCG51_33375	COG1361	Conserved repeat domain
HCG51_33380	COG4636	protein conserved in cyanobacteria
HCG51_33420	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HCG51_33420	COG2205	protein histidine kinase activity
HCG51_33430	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HCG51_33435	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
HCG51_33440	COG0045	succinate-CoA ligase (ADP-forming) activity
HCG51_33475	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
HCG51_33500	COG0456	acetyltransferase
HCG51_33515	COG2223	nitrite transmembrane transporter activity
HCG51_33530	COG0419	ATPase involved in DNA repair
HCG51_33535	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HCG51_33545	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HCG51_33565	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
HCG51_33575	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
HCG51_33580	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
HCG51_33630	COG1131	(ABC) transporter
HCG51_33645	COG2261	transglycosylase associated protein
HCG51_33655	COG5592	hemerythrin HHE cation binding domain
HCG51_33665	COG0826	peptidase U32
HCG51_33675	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
HCG51_33680	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
HCG51_33685	COG2205	protein histidine kinase activity
HCG51_33685	COG0784	Response regulator, receiver
HCG51_33685	COG5002	protein histidine kinase activity
HCG51_33715	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
HCG51_33735	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
HCG51_33750	COG0488	(ABC) transporter
HCG51_33770	COG1132	(ABC) transporter
HCG51_33785	COG2124	cytochrome p450
HCG51_33790	COG1192	Involved in chromosome partitioning
HCG51_33810	COG0745	RESPONSE REGULATOR receiver
HCG51_33815	COG5002	protein histidine kinase activity
HCG51_33820	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
HCG51_33825	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
HCG51_33835	COG2198	Histidine kinase
HCG51_33835	COG0784	Response regulator, receiver
HCG51_33835	COG5002	protein histidine kinase activity
HCG51_33845	COG0109	protoheme IX farnesyltransferase activity
HCG51_33855	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
HCG51_33860	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HCG51_33865	COG1845	cytochrome c oxidase, subunit III
HCG51_33870	COG0515	serine threonine protein kinase
HCG51_33870	COG3266	domain, Protein
HCG51_33945	COG1752	Esterase of the alpha-beta hydrolase superfamily
HCG51_33975	COG0484	heat shock protein binding
HCG51_33990	COG1475	DNA binding
HCG51_33995	COG1192	Involved in chromosome partitioning
HCG51_34250	COG0415	Belongs to the DNA photolyase family
HCG51_34295	COG1741	Belongs to the pirin family
HCG51_34300	COG0667	Aldo Keto reductase
HCG51_34305	COG0667	Aldo Keto reductase
HCG51_34335	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HCG51_34425	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HCG51_34485	COG1487	ribonuclease activity
HCG51_34495	COG0582	viral genome integration into host DNA
HCG51_34635	COG5002	protein histidine kinase activity
HCG51_34645	COG2217	Heavy metal translocating P-type atpase
HCG51_34795	COG0582	viral genome integration into host DNA
HCG51_34850	COG1192	Involved in chromosome partitioning
HCG51_34855	COG1475	DNA binding
HCG51_34880	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HCG51_35050	COG1192	Involved in chromosome partitioning
HCG51_35065	COG1672	PFAM Archaeal ATPase
HCG51_35065	COG2319	Wd-40 repeat
HCG51_35075	COG0582	viral genome integration into host DNA
HCG51_35205	COG0860	N-Acetylmuramoyl-L-alanine amidase
HCG51_35210	COG2340	Cysteine-rich secretory protein family
HCG51_35220	COG1192	Involved in chromosome partitioning
HCG51_35295	COG1192	Involved in chromosome partitioning
HCG51_35300	COG1475	DNA binding