locus-tag class description FO059_00005 ENOG4105CI4 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) FO059_00010 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) FO059_00015 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) FO059_00020 ENOG4105K7N UPF0232 protein FO059_00025 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) FO059_00035 ENOG4105DXM phenylacetic acid degradation protein FO059_00040 ENOG4105E5G Alpha beta hydrolase fold FO059_00050 ENOG4107QZF nitrite reductase NADPH large subunit FO059_00055 ENOG4107QZF nitrite reductase NADPH large subunit FO059_00060 ENOG4108IFG nitrite reductase, (NAD(P)H) FO059_00065 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) FO059_00070 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) FO059_00130 ENOG41090TI Catalyzes the excretion of spermidine (By similarity) FO059_00135 ENOG410814C multidrug resistance protein FO059_00165 ENOG4105CSH Transporter FO059_00170 ENOG4105CH6 catalase FO059_00205 ENOG4105CJP fad dependent oxidoreductase FO059_00225 ENOG4108RZE Tetr family transcriptional regulator FO059_00280 ENOG4105CT3 Monooxygenase FO059_00285 ENOG4105DDW LysR family Transcriptional regulator FO059_00290 ENOG4108JIJ Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second (By similarity) FO059_00315 ENOG4105C3W Catalyzes the oxidative ring opening of 3- hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate (By similarity) FO059_00325 ENOG4105CSH Transporter FO059_00330 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) FO059_00340 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component FO059_00345 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component FO059_00350 ENOG4105D7T ABC transporter FO059_00360 ENOG410839S Toxic component of a toxin-antitoxin (TA) module (By similarity) FO059_00375 ENOG4105CPQ Dehydrogenase FO059_00390 ENOG4107HP6 Transcriptional regulator FO059_00395 ENOG4105IKQ hydratase FO059_00400 ENOG4105DIV Catalyzes the conversion of acetaldehyde to acetyl-CoA, using NAD( ) and coenzyme A. Is the final enzyme in the meta- cleavage pathway for the degradation of aromatic compounds (By similarity) FO059_00405 ENOG4105DF3 Catalyzes the retro-aldol cleavage of 4-hydroxy-2- oxopentanoate to pyruvate and acetaldehyde. Is involved in the meta-cleavage pathway for the degradation of aromatic compounds (By similarity) FO059_00415 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) FO059_00425 ENOG4108R3E Dna-3-methyladenine glycosylase i FO059_00430 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) FO059_00465 ENOG4105M2E Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity) FO059_00495 ENOG4105XBB septation inhibitor protein FO059_00510 ENOG4105D9P serine threonine protein kinase FO059_00515 ENOG4107TPY serine threonine protein kinase FO059_00520 ENOG4105CJN penicillin-binding protein FO059_00535 ENOG4105HZM Fha domain containing protein FO059_00540 ENOG4105TV9 FHA Domain-Containing protein FO059_00575 ENOG4105C57 major facilitator superfamily FO059_00590 ENOG4108MHR Repressor involved in choline regulation of the bet genes (By similarity) FO059_00595 ENOG4105EBR Carboxylesterase FO059_00615 ENOG4105E39 Enoyl-CoA hydratase FO059_00630 ENOG4105C0R drug resistance transporter emrb qaca subfamily FO059_00640 ENOG4108RM3 Phosphatase with a broad specificity. Its primary physiological function is to dephosphorylate 3'-phosphoadenosine 5'-phosphate (PAP) and 3'-phosphoadenosine 5'-phosphosulfate (PAPS). Thus, plays a role in mycobacterial sulfur metabolism, since it can serve as a key regulator of the sulfate assimilation pathway by controlling the pools of PAP and PAPS in the cell. To a lesser extent, is also able to hydrolyze inositol 1-phosphate (I- 1-P), fructose 1,6-bisphosphate (FBP) (to fructose 6-phosphate (F- 6-P)) and AMP in vitro, but this might has no significance in vivo FO059_00645 ENOG4105C11 sulfate adenylyltransferase), subunit 2 FO059_00655 ENOG41069M3 Transcriptional regulator FO059_00660 ENOG4108RK3 acyl-Coa dehydrogenase FO059_00665 ENOG4105X7H acyl-CoA dehydrogenase FO059_00670 ENOG4105D2B acyl-CoA dehydrogenase FO059_00675 ENOG4105F2C Acetyl-CoA acetyltransferase FO059_00680 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase FO059_00715 ENOG4105CEY Amp-dependent synthetase and ligase FO059_00720 ENOG4107QX3 carboxylase FO059_00725 ENOG4107RGH Aldehyde dehydrogenase FO059_00760 ENOG4107QRH Arylsulfatase (Ec 3.1.6.1) FO059_00770 ENOG4105CSH Transporter FO059_00790 ENOG4105CAY ferredoxin--nadp reductase FO059_00810 ENOG4105FBW Monooxygenase FO059_00820 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) FO059_00830 ENOG4105DXM phenylacetic acid degradation protein FO059_00835 ENOG4105E39 Enoyl-CoA hydratase FO059_00860 ENOG4105E2B Taurine dioxygenase FO059_00895 ENOG4105JQZ Methyltransferase FO059_00910 ENOG4105J1Z Arabinosyltransferase FO059_00920 ENOG4105D4F Synthesizes selenophosphate from selenide and ATP (By similarity) FO059_00930 ENOG4105C1Y Converts seryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis (By similarity) FO059_00935 ENOG4105EM7 Selenocysteine-specific translation elongation factor FO059_00940 ENOG4106NMR serine protease FO059_00950 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein FO059_00955 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) FO059_00960 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) FO059_00965 ENOG4105EYF MMPL domain protein FO059_00985 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) FO059_01000 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) FO059_01010 ENOG4105C26 Dehydrogenase FO059_01020 ENOG4105C85 amino acid FO059_01060 ENOG4105F44 Two component transcriptional regulator, winged helix family FO059_01065 ENOG4106F60 Histidine kinase FO059_01070 ENOG4108UQS dipeptidase FO059_01075 ENOG4105CPF Cell wall formation (By similarity) FO059_01090 ENOG4105CFN oxalyl-CoA decarboxylase FO059_01095 ENOG4105EWK phytoene FO059_01130 ENOG4105DTD Dehydrogenase FO059_01160 ENOG4105C1G acyl-Coa dehydrogenase FO059_01165 ENOG4105ETE Transcriptional regulator (LacI family FO059_01170 ENOG4105CBP Major Facilitator FO059_01185 ENOG4105EYF MMPL domain protein FO059_01190 ENOG4105VPX protein, conserved in bacteria FO059_01250 ENOG4107RDP Dehydrogenase FO059_01275 ENOG4105CDA abc transporter atp-binding protein FO059_01280 ENOG4105DRP amino acid AbC transporter FO059_01290 ENOG4106ZX3 phosphonate ABC transporter, periplasmic phosphonate-binding protein FO059_01295 ENOG4105D5T phosphonate abc transporter FO059_01300 ENOG4105S7S phosphonate abc transporter FO059_01310 ENOG4108KAZ Involved in phosphonate degradation (By similarity) FO059_01315 ENOG4105CPQ Dehydrogenase FO059_01335 ENOG4105H37 Glyoxalase Bleomycin resistance protein (Dioxygenase FO059_01370 ENOG4105KF3 Short-chain dehydrogenase reductase Sdr FO059_01390 ENOG4105C1G acyl-Coa dehydrogenase FO059_01410 ENOG4105CPC Aldo Keto reductase FO059_01420 ENOG41076PI Short-chain dehydrogenase reductase Sdr FO059_01425 ENOG41076PI Short-chain dehydrogenase reductase Sdr FO059_01435 ENOG4105CHR reductase FO059_01470 ENOG4107QJZ Glycosyl transferase, family 2 FO059_01520 ENOG4108BAS reductase FO059_01535 ENOG4105DAB fumarate reductase succinate dehydrogenase flavoprotein domain protein FO059_01550 ENOG4105CVJ phosphoglycerate mutase FO059_01555 ENOG4105CI2 imidazolone-5-propionate hydrolase FO059_01560 ENOG4107S2E monooxygenase FO059_01605 ENOG4105KT7 mgtC SapB transporter FO059_01635 ENOG4105D8X mechanosensitive ion channel FO059_01665 ENOG4105ECB domain protein FO059_01665 ENOG4105ECB domain protein FO059_01670 ENOG4105CVK Glutamate decarboxylase FO059_01690 ENOG4105D7W serine acetyltransferase FO059_01695 ENOG4105CAY ferredoxin--nadp reductase FO059_01700 ENOG4105CBC glutamate synthase FO059_01715 ENOG410848D S4 domain protein YaaA FO059_01725 ENOG4108QIU Dehydrogenase FO059_01730 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase FO059_01745 ENOG4108YYX Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome. Modulates RNA-binding and helicase activities of the degradosome (By similarity) FO059_01755 ENOG4105EXU Membrane FO059_01765 ENOG4105V1F Fermentation respiration switch protein FO059_01775 ENOG4105FF5 Membrane FO059_01815 ENOG4107TXC Transcriptional regulator FO059_01830 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) FO059_01870 ENOG4105CT3 Monooxygenase FO059_01895 ENOG4108HW8 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) FO059_01905 ENOG4105D17 glycoside hydrolase, family 3 domain protein FO059_01910 ENOG41079Y2 Catalyzes the coenzyme F420-dependent oxidation of glucose 6-phosphate (G6P) to 6-phosphogluconolactone FO059_01915 ENOG41061CK Antibiotic biosynthesis monooxygenase FO059_01920 ENOG4105VFE sira family FO059_01945 ENOG4108KGH TRANSCRIPTIONal FO059_01970 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein FO059_01975 ENOG4105CQC Prephenate dehydratase FO059_02020 ENOG4105F9F transposase FO059_02030 ENOG4105F9F transposase FO059_02040 ENOG4105F9F transposase FO059_02050 ENOG4105C4R Atp-dependent dna helicase FO059_02090 ENOG4105CGR Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) FO059_02115 ENOG4107B57 rieske 2fe-2S domain-containing protein FO059_02125 ENOG410667J hydrolase FO059_02130 ENOG4105JFG SpoIID LytB domain protein FO059_02140 ENOG410602S Transferase FO059_02150 ENOG4106YN8 Prenyltransferase FO059_02155 ENOG4107ISF Involved in the biosynthesis of the arabinogalactan (AG) region of the mycolylarabinogalactan-peptidoglycan (mAGP) complex, an essential component the mycobacterial cell wall. Catalyzes the transfer of arabinofuranosyl (Araf) residues residue from the sugar donor beta-D-arabinofuranosyl-1-monophosphoryldecaprenol (DPA) to the arabinan domain to form terminal beta-(1- 2)-linked Araf residues, which marks the end point for AG arabinan biosynthesis before decoration with mycolic acids FO059_02165 ENOG4107YB1 Trehalose corynomycolyl transferase FO059_02180 ENOG4107RCI amp-dependent synthetase and ligase FO059_02190 ENOG4105D8K carboxyl transferase FO059_02205 ENOG4105J1Z Arabinosyltransferase FO059_02210 ENOG4108K7T Involved in the biosynthesis of the arabinogalactan (AG) region of the mycolylarabinogalactan-peptidoglycan (mAGP) complex, an essential component the mycobacterial cell wall. Catalyzes the addition of the first key arabinofuranosyl (Araf) residue from the sugar donor beta-D-arabinofuranosyl-1-monophosphoryldecaprenol (DPA) on the C-5 of a 6-linked galactofuranosyl (Galf) of the galactan domain, thus 'priming' the galactan for further elaboration by other arabinofuranosyltransferases FO059_02215 ENOG4108RG3 short-chain dehydrogenase reductase FO059_02220 ENOG4105IQ5 FAD linked oxidase domain protein FO059_02230 ENOG410602S Transferase FO059_02240 ENOG4105C26 Dehydrogenase FO059_02255 ENOG4108MKI Glycosyl transferase, family 2 FO059_02270 ENOG4108VC7 Protein of unknown function (DUF2587) FO059_02295 ENOG4105E5G Alpha beta hydrolase fold FO059_02300 ENOG4105CGH 5'-nucleotidase FO059_02305 ENOG4105CIH Imidazole acetol-phosphate transaminase FO059_02335 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) FO059_02340 ENOG4105EVN Prephenate dehydrogenase FO059_02350 ENOG4108Z6B deaminase FO059_02360 ENOG4108HMN Caspase domain FO059_02370 ENOG4105VPX protein, conserved in bacteria FO059_02375 ENOG4105C6U Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity) FO059_02385 ENOG4106F3G Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5- dihydroxy-2-cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon (By similarity) FO059_02410 ENOG4105XT2 Transcriptional regulator FO059_02425 ENOG4105E6M Sulphatase-modifying factor protein FO059_02435 ENOG4107QRH Arylsulfatase (Ec 3.1.6.1) FO059_02455 ENOG4105C1J atp-dependent rna helicase FO059_02465 ENOG4107QRH Arylsulfatase (Ec 3.1.6.1) FO059_02475 ENOG4105CHR reductase FO059_02495 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase FO059_02510 ENOG4105F3K May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) FO059_02520 ENOG4105CAA catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) FO059_02525 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) FO059_02530 ENOG4107QXN Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) FO059_02535 ENOG4105CH6 catalase FO059_02540 ENOG4105CVG Homoserine O-transsuccinylase FO059_02545 ENOG4105FG0 Nitroreductase FO059_02550 ENOG4105CFH Aspartokinase FO059_02570 ENOG4105EUB pirin domain protein FO059_02575 ENOG4105WKW Pfam:DUF1458 FO059_02580 ENOG41083YR Protein CrcB homolog FO059_02585 ENOG41083TI Protein CrcB homolog FO059_02605 ENOG4105DIN metallophosphoesterase FO059_02615 ENOG4108JQC penicillin-binding protein 1A FO059_02645 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) FO059_02665 ENOG4107QXG alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen FO059_02670 ENOG4105P8F nudix hydrolase FO059_02690 ENOG4105DRC Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) FO059_02745 ENOG4108I5C dEAD DEAH box helicase FO059_02760 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) FO059_02770 ENOG4105F8J Adenylate Guanylate cyclase FO059_02780 ENOG4107QRG dna polymerase iii FO059_02810 ENOG4108URP Dtdp-4-dehydrorhamnose 3,5-epimerase FO059_02815 ENOG4107QPT Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) FO059_02830 ENOG4105DA5 (ABC) transporter FO059_02840 ENOG4105CHU acetyl-coa acetyltransferase FO059_02855 ENOG4108RYC glycosyltransferase FO059_02890 ENOG4105C0R drug resistance transporter emrb qaca subfamily FO059_02900 ENOG4107RVU D-Ala-D-Ala carboxypeptidase 3 (S13) family FO059_02910 ENOG4107RD1 Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) FO059_02925 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) FO059_02930 ENOG4105EUJ GTP cyclohydrolase i FO059_02965 ENOG4108IAA Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity) FO059_02970 ENOG4108Z2X Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine (By similarity) FO059_02975 ENOG4105CGM Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis (By similarity) FO059_02985 ENOG4105CRK lysyL-tRNA synthetase FO059_03005 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit FO059_03010 ENOG4108Z9K Osmotically inducible protein FO059_03030 ENOG4108V9Q carbonic anhydrase FO059_03040 ENOG4105E59 Participates in a DNA-damage check-point. DisA forms globular foci that rapidly scan along the chromosomes searching for lesions (By similarity) FO059_03050 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) FO059_03060 ENOG4108VJ1 Transcriptional regulator (CarD family FO059_03065 ENOG4108UH8 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity) FO059_03070 ENOG4105C8N cysteinyl-tRNA synthetase FO059_03075 ENOG4105C2N RNA methyltransferase TrmH family group 3 FO059_03080 ENOG4105C1G acyl-Coa dehydrogenase FO059_03090 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase FO059_03095 ENOG4108RH7 phosphoglycerate mutase FO059_03105 ENOG4107QIV Cytochrome c biogenesis protein FO059_03115 ENOG4105CRE cytochrome C FO059_03145 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit FO059_03235 ENOG4107TCW O-succinylbenzoate synthase FO059_03250 ENOG4105C4A Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity) FO059_03260 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) FO059_03265 ENOG4105P52 geranylgeranyl reductase FO059_03285 ENOG4105C94 Transporter FO059_03290 ENOG4108VPT UPF0234 protein FO059_03315 ENOG410900P UPF0336 protein FO059_03320 ENOG4108F01 MaoC domain protein FO059_03330 ENOG410683Z Preprotein translocase SecE subunit FO059_03340 ENOG4108UIK This protein binds directly to 23S ribosomal RNA (By similarity) FO059_03345 ENOG4105C64 Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity) FO059_03350 ENOG4108VZM 50s ribosomal protein L10 FO059_03355 ENOG41082SK Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity) FO059_03415 ENOG4108IIJ DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) FO059_03420 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) FO059_03425 ENOG4105M4E phosphohistidine phosphatase, SixA FO059_03435 ENOG4105C0R drug resistance transporter emrb qaca subfamily FO059_03460 ENOG4105CHU acetyl-coa acetyltransferase FO059_03470 ENOG410900P UPF0336 protein FO059_03475 ENOG4105KF3 Short-chain dehydrogenase reductase Sdr FO059_03480 ENOG4105D2B acyl-CoA dehydrogenase FO059_03500 ENOG4105D3Z quinone oxidoreductase, yhdh yhfp family FO059_03535 ENOG4107QX3 carboxylase FO059_03560 ENOG4105CEY Amp-dependent synthetase and ligase FO059_03580 ENOG4108UKE Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity) FO059_03585 ENOG4108UHY One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity) FO059_03590 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) FO059_03595 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) FO059_03620 ENOG4105VBF alkaline shock protein FO059_03625 ENOG410846T CoA-transferase family III FO059_03640 ENOG4108IUE nitrate reductase beta subunit FO059_03660 ENOG4105MKU Transcriptional regulator FO059_03670 ENOG4105C1G acyl-Coa dehydrogenase FO059_03690 ENOG4105EC0 Required for nucleoid occlusion (NO) phenomenon, which prevents Z-ring formation and cell division over the nucleoid. Acts as a DNA-associated cell division inhibitor that binds simultaneously chromosomal DNA and FtsZ, and disrupts the assembly of FtsZ polymers. SlmA-DNA-binding sequences (SBS) are dispersed on non-Ter regions of the chromosome, preventing FtsZ polymerization at these regions (By similarity) FO059_03695 ENOG4105CGU Enoyl-CoA hydratase FO059_03765 ENOG4105EEE One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) FO059_03770 ENOG4106U5A One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) FO059_03775 ENOG4105KZR One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity) FO059_03780 ENOG4105CFD One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity FO059_03785 ENOG4105K7S Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity) FO059_03790 ENOG4105KAP The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity) FO059_03800 ENOG4108R70 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity) FO059_03805 ENOG41082SA 50s ribosomal protein l29 FO059_03810 ENOG4105K87 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal FO059_03820 ENOG4105KAR One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity) FO059_03825 ENOG4105CW6 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits FO059_03830 ENOG41082QR Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) FO059_03835 ENOG4108UJY One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity) FO059_03840 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) FO059_03845 ENOG4105K4C This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity) FO059_03850 ENOG4108RA9 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) FO059_03855 ENOG410849U 50S ribosomal protein L30 FO059_03860 ENOG4108UZ0 Binds to the 23S rRNA (By similarity) FO059_03870 ENOG4105CC8 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) FO059_03880 ENOG4108YYA Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity) FO059_03890 ENOG4105K9U however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) FO059_03895 ENOG41067V7 50S ribosomal protein L36 FO059_03900 ENOG4108Z04 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits FO059_03905 ENOG4108UHH Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) FO059_03910 ENOG4105G6W One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) FO059_03915 ENOG4105CTF DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) FO059_03920 ENOG4108ZT0 50S ribosomal protein l17 FO059_03925 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) FO059_03935 ENOG4108UM5 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity) FO059_03940 ENOG4108UJD 30S ribosomal protein S9 FO059_03945 ENOG4107QJF Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) FO059_03970 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) FO059_03990 ENOG4108URP Dtdp-4-dehydrorhamnose 3,5-epimerase FO059_04005 ENOG4105EJZ Glucose-1-phosphate cytidylyltransferase FO059_04015 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase FO059_04030 ENOG4107QPH glycogen) synthase FO059_04035 ENOG4105CPK Glycosyl transferase (Group 1 FO059_04060 ENOG4105C6Y Udp-glucose 6-dehydrogenase FO059_04065 ENOG4107QRS glycosyltransferase group 2 family protein FO059_04080 ENOG41064MX Tetr family transcriptional regulator FO059_04090 ENOG4108KGH TRANSCRIPTIONal FO059_04095 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) FO059_04110 ENOG41080E2 ribosomal-protein-alanine acetyltransferase FO059_04115 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) FO059_04130 ENOG4105K5Y Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity) FO059_04135 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) FO059_04140 ENOG4105KIU Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA (By similarity) FO059_04165 ENOG4108VT4 FO059_04175 ENOG4107QVP Dehydrogenase FO059_04210 ENOG4105DRC Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) FO059_04245 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) FO059_04265 ENOG4105WH1 Two component transcriptional regulator luxr family FO059_04270 ENOG4107PMW Arabinan endo-1,5-alpha-L-arabinosidase FO059_04275 ENOG4105D9P serine threonine protein kinase FO059_04280 ENOG410832A alpha/beta hydrolase fold FO059_04345 ENOG4108KPJ rna polymerase sigma factor FO059_04350 ENOG4105VDM plasmid maintenance system antidote protein, xre family FO059_04360 ENOG4107ZN8 Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) FO059_04385 ENOG4105C0B DNA polymerase III (alpha subunit) FO059_04410 ENOG4107RR1 TRANSCRIPTIONal FO059_04420 ENOG4105RHA ABC transporter, permease FO059_04425 ENOG4108IUX (ABC) transporter FO059_04445 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) FO059_04455 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) FO059_04470 ENOG4108IQK o-acetylhomoserine FO059_04485 ENOG4105F27 Major Facilitator FO059_04490 ENOG4105CGK Exodeoxyribonuclease III FO059_04505 ENOG4105C2X Arabinose 5-phosphate isomerase FO059_04510 ENOG4105C31 Tryptophanyl-tRNA synthetase FO059_04515 ENOG4107H3J ribonuclease FO059_04520 ENOG4105CQB FAD linked oxidase domain protein FO059_04560 ENOG4107QM5 aconitate hydratase FO059_04565 ENOG4105E33 succinate dehydrogenase FO059_04570 ENOG4105C00 Succinate dehydrogenase (Flavoprotein subunit) FO059_04595 ENOG4108CCU Ribonucleotide-diphosphate reductase subunit beta FO059_04600 ENOG4105EKD Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity) FO059_04615 ENOG4105CZ5 Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity) FO059_04635 ENOG4107RM1 amidohydrolase FO059_04655 ENOG4107QVN Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) FO059_04690 ENOG4108JIK carboxylase FO059_04715 ENOG4107WR6 Maf-like protein FO059_04725 ENOG4105D8K carboxyl transferase FO059_04730 ENOG4105HJX Biotin- acetyl-CoA-carboxylase ligase FO059_04755 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit FO059_04780 ENOG4105CQB FAD linked oxidase domain protein FO059_04800 ENOG4107TB5 TRANSCRIPTIONal FO059_04830 ENOG41088YA Catalyzes the GTP-dependent successive addition of two or more gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form coenzyme F420-0-glutamyl-glutamate (F420-2) or polyglutamated F420 derivatives (By similarity) FO059_04850 ENOG4107QKV phosphomannomutase FO059_04855 ENOG4105W49 UPF0434 protein FO059_04865 ENOG4105EIP mannose-6-phosphate isomerase FO059_04875 ENOG4105C3E May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine (By similarity) FO059_04885 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FO059_04890 ENOG4105BZU Histidine kinase FO059_04895 ENOG4108MKR lipoprotein lpqb FO059_04905 ENOG4108S7Q sigma 54 modulation protein ribosomal protein S30ea FO059_04910 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving FO059_04970 ENOG4105DYW oxidoreductase FO059_05015 ENOG4105E39 Enoyl-CoA hydratase FO059_05030 ENOG4105CEI nitrite reductase FO059_05050 ENOG4108KC2 acyl-Coa dehydrogenase FO059_05055 ENOG4105X7H acyl-CoA dehydrogenase FO059_05065 ENOG4105CY3 ABC transporter, permease FO059_05115 ENOG4105C1K alpha-alpha-trehalose-phosphate synthase FO059_05140 ENOG4108UQY Iron-storage protein FO059_05155 ENOG4107ZUX Histidine triad (HIT) protein FO059_05160 ENOG4105C12 Phosphoribosylglycinamide synthetase FO059_05165 ENOG4105CHM Aminotransferase FO059_05175 ENOG4105C83 adenylosuccinate lyase FO059_05180 ENOG4105C8V SAICAR synthetase FO059_05195 ENOG4105F4R Transcriptional regulator mode FO059_05200 ENOG4108V06 Glutathione peroxidase FO059_05210 ENOG410839H phosphoribosylformylglycinamidine synthase FO059_05215 ENOG4105D21 Phosphoribosylformylglycinamidine synthase I FO059_05230 ENOG4105DFM M18 family aminopeptidase FO059_05235 ENOG4108JIU phosphoribosylformylglycinamidine synthase ii FO059_05260 ENOG4105CXB phosphoribosylaminoimidazole synthetase FO059_05270 ENOG4106XY2 Folate-binding protein involved in regulating the level of ATP-DnaA and in the modification of some tRNAs. It is probably a key factor in regulatory networks that act via tRNA modification, such as initiation of chromosomal replication (By similarity) FO059_05275 ENOG4107Z5F Aminotransferase class IV FO059_05280 ENOG41064MX Tetr family transcriptional regulator FO059_05285 ENOG4108SVG May play a role in the intracellular transport of hydrophobic ligands FO059_05290 ENOG4105PKJ carbohydrate binding FO059_05295 ENOG4105KHC sulfurtransferase FO059_05315 ENOG4107NHD transcriptional regulator FO059_05320 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) FO059_05325 ENOG4107QJG Part of the ABC transporter complex PstSACB involved in phosphate import (By similarity) FO059_05340 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) FO059_05345 ENOG4105CSU acyl-Coa dehydrogenase FO059_05375 ENOG4105J5T Amp-dependent synthetase and ligase FO059_05430 ENOG4105C0R drug resistance transporter emrb qaca subfamily FO059_05445 ENOG4105CEY Amp-dependent synthetase and ligase FO059_05450 ENOG4107QX3 carboxylase FO059_05460 ENOG4105C1G acyl-Coa dehydrogenase FO059_05465 ENOG4105DJG MaoC domain protein dehydratase FO059_05485 ENOG4105CH2 amidohydrolase FO059_05490 ENOG41090TK Short-chain dehydrogenase reductase Sdr FO059_05495 ENOG4105CHR reductase FO059_05505 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) FO059_05545 ENOG4108SGK Tetr family transcriptional regulator FO059_05565 ENOG4105J5T Amp-dependent synthetase and ligase FO059_05570 ENOG4105CEY Amp-dependent synthetase and ligase FO059_05580 ENOG4105J5T Amp-dependent synthetase and ligase FO059_05590 ENOG4107ZQV short-chain dehydrogenase reductase FO059_05610 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) FO059_05620 ENOG4105C26 Dehydrogenase FO059_05625 ENOG4105C1G acyl-Coa dehydrogenase FO059_05680 ENOG41067TZ transcriptional regulator, MarR family FO059_05690 ENOG4105CZ6 Can catalyze the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine (By similarity) FO059_05700 ENOG4107QYE Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) FO059_05715 ENOG4105CR4 methylisocitrate lyase FO059_05725 ENOG4105CFF transcriptional regulator FO059_05745 ENOG4105C0A alcohol dehydrogenase FO059_05780 ENOG4105WH1 Two component transcriptional regulator luxr family FO059_05805 ENOG4105XDV FO059_05820 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase FO059_05840 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase FO059_05850 ENOG4106BQ7 Glycosyl Transferase FO059_05855 ENOG4107RR1 TRANSCRIPTIONal FO059_05860 ENOG4105C26 Dehydrogenase FO059_05880 ENOG4108ZX5 transcriptional regulator FO059_05885 ENOG4105C1G acyl-Coa dehydrogenase FO059_05900 ENOG4105CHU acetyl-coa acetyltransferase FO059_05905 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase FO059_05965 ENOG4105F95 Monooxygenase FO059_05975 ENOG4105CFI type iii restriction protein res subunit FO059_05995 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) FO059_06015 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) FO059_06035 ENOG4105VEQ Cold shock protein FO059_06045 ENOG4108N0W Major Facilitator superfamily FO059_06065 ENOG4105C7N Xanthine uracil vitamin C permease FO059_06080 ENOG4105C1G acyl-Coa dehydrogenase FO059_06090 ENOG4107R8H Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity) FO059_06105 ENOG41081K0 peptidylprolyl cis-trans isomerase FO059_06110 ENOG4105DRC Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) FO059_06130 ENOG4105C26 Dehydrogenase FO059_06135 ENOG4105C94 Transporter FO059_06140 ENOG4105DGI Alkaline phosphatase FO059_06165 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) FO059_06185 ENOG4105C52 Atpase, p-type (Transporting), had superfamily, subfamily ic FO059_06200 ENOG4105DW0 Catalyzes the ADP transfer to D-glycero-D-manno-heptose 1-phosphate, yielding ADP-D,D-heptose (By similarity) FO059_06210 ENOG4105EBR Carboxylesterase FO059_06230 ENOG4105D7N magnesium and cobalt transport protein CorA FO059_06270 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase FO059_06280 ENOG4107YXZ hydrolase, family 25 FO059_06295 ENOG4105C0V Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity) FO059_06305 ENOG4107QP8 phosphohexose isomerase FO059_06335 ENOG4105DR5 peptidase FO059_06340 ENOG4105CMV Succinyl-CoA synthetase subunit beta FO059_06380 ENOG4107KWJ von Willebrand factor, type A FO059_06390 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) FO059_06395 ENOG4105EN6 Membrane FO059_06400 ENOG4105ETX regulatoR FO059_06405 ENOG41062D9 Histidine kinase FO059_06415 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) FO059_06435 ENOG41080UU 5-formyltetrahydrofolate cyclo-ligase FO059_06440 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase FO059_06450 ENOG4105D9U N-acetyltransferase FO059_06495 ENOG4107SEV 1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate dehydrogenase FO059_06530 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family FO059_06555 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) FO059_06560 ENOG4105F8V Hydrolase, tatD family FO059_06570 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) FO059_06575 ENOG4105CTR Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity) FO059_06580 ENOG4105C5H ABC transporter FO059_06585 ENOG4105E39 Enoyl-CoA hydratase FO059_06595 ENOG4105C8A Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP (By similarity) FO059_06600 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) FO059_06605 ENOG4107XT7 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity) FO059_06615 ENOG4105K89 arsenate reductase FO059_06625 ENOG4105E46 N-alpha,N-alpha,N-alpha-trimethyl-L-histidine metabolic process FO059_06630 ENOG4108V75 Glutamine amidotransferase FO059_06635 ENOG41067HS methyltransferase FO059_06660 ENOG4105FDP GntR family transcriptional regulator FO059_06665 ENOG4105DKW ABC transporter FO059_06685 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) FO059_06690 ENOG4105KPY Small multidrug resistance protein FO059_06705 ENOG4107RNA Nickel ABC transporter, periplasmic nickel-binding protein FO059_06710 ENOG4105DEF Extracellular solute-binding protein, family 5 FO059_06730 ENOG4105CBG Sulfatase FO059_06735 ENOG4105E6M Sulphatase-modifying factor protein FO059_06740 ENOG4105XEA Tetr family transcriptional regulator FO059_06755 ENOG41082JN Transcriptional regulator FO059_06765 ENOG4105DXN mazG family FO059_06785 ENOG4105E2B Taurine dioxygenase FO059_06795 ENOG4105C70 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) FO059_06825 ENOG4108RAV Conserved protein FO059_06835 ENOG4105CHU acetyl-coa acetyltransferase FO059_06845 ENOG4108ZXC Two component transcriptional regulator, luxr family FO059_06870 ENOG4107RN6 Monooxygenase FO059_06880 ENOG4105CIG ABC transporter FO059_06885 ENOG4105DIM ABC transporter FO059_06905 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) FO059_06990 ENOG4105BZK Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair (By similarity) FO059_07010 ENOG4107YD5 Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) FO059_07020 ENOG4105T1M mycothiol conjugate amidase mca FO059_07030 ENOG4105C7Z Conserved Protein FO059_07035 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) FO059_07065 ENOG4105CS9 pantothenic acid kinase FO059_07075 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) FO059_07090 ENOG4105C0D helicase FO059_07095 ENOG4108IAB Phoh family FO059_07115 ENOG4108RM3 Phosphatase with a broad specificity. Its primary physiological function is to dephosphorylate 3'-phosphoadenosine 5'-phosphate (PAP) and 3'-phosphoadenosine 5'-phosphosulfate (PAPS). Thus, plays a role in mycobacterial sulfur metabolism, since it can serve as a key regulator of the sulfate assimilation pathway by controlling the pools of PAP and PAPS in the cell. To a lesser extent, is also able to hydrolyze inositol 1-phosphate (I- 1-P), fructose 1,6-bisphosphate (FBP) (to fructose 6-phosphate (F- 6-P)) and AMP in vitro, but this might has no significance in vivo FO059_07175 ENOG4105DVS Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) FO059_07185 ENOG4105C48 Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity) FO059_07205 ENOG4105EYH Exonuclease FO059_07210 ENOG4105C02 permease FO059_07220 ENOG4105C3G gtp-binding protein FO059_07260 ENOG4105H3G oxidoreductase FO059_07270 ENOG41082YX Transcriptional regulator, arsr family FO059_07275 ENOG41080E2 ribosomal-protein-alanine acetyltransferase FO059_07285 ENOG4105W1Y Transcriptional regulator FO059_07290 ENOG41080ET plasmid maintenance system killer protein FO059_07295 ENOG4105VDM plasmid maintenance system antidote protein, xre family FO059_07350 ENOG4105DXI Major Facilitator superfamily FO059_07360 ENOG4105K5X acetyltransferase FO059_07375 ENOG4105PTV Nudix Hydrolase FO059_07395 ENOG4105F9F transposase FO059_07400 ENOG4105F9F transposase FO059_07415 ENOG4105IDI abc transporter atp-binding protein FO059_07420 ENOG4105CSV Glutaminase FO059_07435 ENOG4105ES3 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) FO059_07445 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) FO059_07455 ENOG4108IEH NADH dehydrogenase subunit g FO059_07460 ENOG4105CMZ NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone (By similarity) FO059_07465 ENOG4105P3U NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) FO059_07470 ENOG4105DF2 NADH dehydrogenase subunit j FO059_07475 ENOG4105M5H NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) FO059_07490 ENOG4105CNR NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) FO059_07520 ENOG4107GFK fumarate FO059_07565 ENOG410842T Pterin carbinolamine dehydratase FO059_07580 ENOG4108UCS ABC, transporter FO059_07585 ENOG4105CI3 gtp-binding protein typa FO059_07590 ENOG4107USK Extracellular solute-binding protein, family 5 FO059_07595 ENOG4108KZ5 Catalyzes the deacetylation of 1D-myo-inositol 2- acetamido-2-deoxy-alpha-D-glucopyranoside (GlcNAc-Ins) in the mycothiol biosynthesis pathway (By similarity) FO059_07605 ENOG4105DKF Catalyzes the radical-mediated transfer of the hydroxybenzyl group from 4-hydroxyphenylpyruvate (HPP) to 5-amino- 6-ribitylamino-2,4(1H,3H)-pyrimidinedione to form 7,8-didemethyl- 8-hydroxy-5-deazariboflavin (FO) (By similarity) FO059_07610 ENOG4108Z4U Ferredoxin FO059_07630 ENOG4105CEY Amp-dependent synthetase and ligase FO059_07635 ENOG410905P Pyridoxamine 5-phosphate FO059_07655 ENOG4105C85 amino acid FO059_07665 ENOG4107R4C succinyl-diaminopimelate desuccinylase FO059_07680 ENOG4105EEI dihydropteroate synthase FO059_07685 ENOG4105C3Q Glycosyl transferase, family 2 FO059_07705 ENOG4107ZBN O-methyltransferase FO059_07715 ENOG4106684 FO059_07725 ENOG4105UTW Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation (By similarity) FO059_07745 ENOG4105CJW magnesium transporter FO059_07765 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) FO059_07775 ENOG4105DB7 PHP domain protein FO059_07805 ENOG4107RN6 Monooxygenase FO059_07810 ENOG4108MHR Repressor involved in choline regulation of the bet genes (By similarity) FO059_07815 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 FO059_07820 ENOG4105BZ1 (ABC) transporter FO059_07875 ENOG4105CC9 acyl-Coa dehydrogenase FO059_07880 ENOG4105C1G acyl-Coa dehydrogenase FO059_07895 ENOG4105EBR Carboxylesterase FO059_07900 ENOG4108WKN secreted protein FO059_07930 ENOG4108IIE The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) FO059_07935 ENOG4108IIE The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) FO059_07940 ENOG4105C15 The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) FO059_07945 ENOG4105C0R drug resistance transporter emrb qaca subfamily FO059_07955 ENOG4107RN0 branched-chain alpha-keto acid dehydrogenase subunit E2 FO059_07960 ENOG4105CPP Dehydrogenase, E1 component FO059_07985 ENOG4105C0D helicase FO059_07995 ENOG4108151 Beta-lactamase domain protein FO059_08010 ENOG4105C75 arginyL-tRNA synthetase FO059_08015 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) FO059_08020 ENOG4105D6E homoserine dehydrogenase FO059_08025 ENOG4107R5I Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine (By similarity) FO059_08030 ENOG4105D5I Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity) FO059_08035 ENOG4105CEY Amp-dependent synthetase and ligase FO059_08045 ENOG4105VFB Binds the 23S rRNA (By similarity) FO059_08050 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) FO059_08055 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) FO059_08075 ENOG4107UH5 it plays a direct role in the translocation of protons across the membrane (By similarity) FO059_08080 ENOG4105ZA1 atp synthase FO059_08085 ENOG4107Z0K Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0) (By similarity) FO059_08090 ENOG4108SBS F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) FO059_08095 ENOG4105CDG Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity) FO059_08100 ENOG4105J80 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity) FO059_08105 ENOG4105C4J Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) FO059_08110 ENOG410825K Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) FO059_08125 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) FO059_08150 ENOG4105DSU hydrolase FO059_08160 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) FO059_08180 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) FO059_08200 ENOG4108KVX Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves (By similarity) FO059_08205 ENOG4105K8I Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity) FO059_08210 ENOG4105FE9 pseudouridine synthase FO059_08215 ENOG4105CAT Cytidine monophosphate kinase FO059_08220 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) FO059_08235 ENOG4105P8F nudix hydrolase FO059_08240 ENOG4107R37 Glutamate dehydrogenase FO059_08270 ENOG4108UW8 fha domain-containing protein FO059_08290 ENOG4105CBI The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor FO059_08300 ENOG4107UAX integral membrane protein FO059_08315 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) FO059_08335 ENOG4105CEP NADH dehydrogenase FO059_08380 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein FO059_08385 ENOG4105E2B Taurine dioxygenase FO059_08415 ENOG4105CEY Amp-dependent synthetase and ligase FO059_08455 ENOG4105C26 Dehydrogenase FO059_08465 ENOG4107QRI Phosphoketolase FO059_08470 ENOG4107R7Y intracellular protease Pfpi family FO059_08490 ENOG4105Q70 FO059_08505 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) FO059_08525 ENOG4105CBC glutamate synthase FO059_08530 ENOG4105EQW The exact function is not known. Can catalyze the reduction of a variety of substrates like dimethyl sulfoxide, trimethylamine N-oxide, phenylmethyl sulfoxide and L-methionine sulfoxide. Cannot reduce cyclic N-oxides. Shows no activity as sulfite oxidase (By similarity) FO059_08545 ENOG4105CI2 imidazolone-5-propionate hydrolase FO059_08555 ENOG4105CJW magnesium transporter FO059_08570 ENOG4105DEN Luciferase family FO059_08575 ENOG4108RG3 short-chain dehydrogenase reductase FO059_08615 ENOG41067S4 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) FO059_08630 ENOG4105DVV Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine (By similarity) FO059_08640 ENOG4105KPK Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation (By similarity) FO059_08650 ENOG4105E5F proteasome FO059_08655 ENOG4105DHM ATPase which is responsible for recognizing, binding, unfolding and translocation of pupylated proteins into the bacterial 20S proteasome core particle. May be essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C-termini of the proteasomal ATPase may function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis (By similarity) FO059_08675 ENOG4105E21 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) FO059_08685 ENOG4105C3R Methionine synthase FO059_08695 ENOG4105C8N cysteinyl-tRNA synthetase FO059_08715 ENOG4105CPC Aldo Keto reductase FO059_08730 ENOG4107R4I Periplasmic binding protein FO059_08735 ENOG4105EHG Permease protein FO059_08740 ENOG4108IPX Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system (By similarity) FO059_08765 ENOG4107QYT Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor (By similarity) FO059_08780 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) FO059_08835 ENOG4108UF8 FO059_08840 ENOG4107QME Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) FO059_08845 ENOG4105CSJ Enoyl- acyl-carrier-protein reductase NADH FO059_08850 ENOG4105CHR reductase FO059_08855 ENOG4107QVM von Willebrand factor, type A FO059_08865 ENOG4105C7R Atpase associated with various cellular activities aaa_3 FO059_08870 ENOG4105ZXU NLP P60 protein FO059_08880 ENOG4107QM5 aconitate hydratase FO059_08885 ENOG4108Q5F Tetr family transcriptional regulator FO059_08890 ENOG4105C5H ABC transporter FO059_08895 ENOG4105CHR reductase FO059_08910 ENOG4105VG1 fes assembly suf system protein FO059_08915 ENOG4108UNV SUF system FeS assembly protein, NifU family FO059_08925 ENOG4105C3K feS assembly ATPase SufC FO059_08945 ENOG4107JC6 Membrane FO059_08950 ENOG4105CJ1 ABC, transporter FO059_08965 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein FO059_08970 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) FO059_08980 ENOG4107QQX Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) FO059_09000 ENOG4105MN3 Resolvase FO059_09030 ENOG4105CP7 Triose-phosphate isomerase FO059_09035 ENOG4105BZA Phosphoglycerate kinase FO059_09040 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase FO059_09045 ENOG4105CIE May be required for sporulation (By similarity) FO059_09070 ENOG4108UTT Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) FO059_09075 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) FO059_09100 ENOG4105CAE Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) FO059_09115 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP FO059_09130 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) FO059_09145 ENOG4105SKN orotidine 5''-phosphate decarboxylase FO059_09150 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain FO059_09155 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain FO059_09170 ENOG4105CXT aspartate transcarbamylase FO059_09180 ENOG410803B Involved in the transcription termination process (By similarity) FO059_09185 ENOG4105DRH Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) FO059_09205 ENOG4105D49 3-dehydroquinate synthase FO059_09210 ENOG4105KHV Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) FO059_09225 ENOG4105E2X shikimate dehydrogenase FO059_09235 ENOG41080G3 Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) FO059_09240 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) FO059_09255 ENOG4105C9M aspartyl-trna synthetase FO059_09265 ENOG4105C7K acetolactate synthase FO059_09270 ENOG4105CMT Dihydroxyacetone kinase FO059_09280 ENOG4105J5T Amp-dependent synthetase and ligase FO059_09290 ENOG4107S5Z Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domain of GcvH, an intermediate carrier during protein lipoylation (By similarity) FO059_09315 ENOG4105CJQ hydrolase, family 31 FO059_09340 ENOG4107R95 Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) FO059_09360 ENOG4105CJQ hydrolase, family 31 FO059_09365 ENOG4105C87 Aminotransferase class I and II FO059_09395 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) FO059_09455 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving FO059_09470 ENOG4105CSH Transporter FO059_09485 ENOG4105M2Z protein tyrosine serine phosphatase FO059_09495 ENOG4105CJ1 ABC, transporter FO059_09525 ENOG4105CH2 amidohydrolase FO059_09535 ENOG4105DV0 amidase (EC 3.5.1.4 FO059_09565 ENOG4105CEP NADH dehydrogenase FO059_09570 ENOG41061JJ Peptidase family M23 FO059_09580 ENOG4108XG2 Histidine kinase FO059_09585 ENOG4105WH1 Two component transcriptional regulator luxr family FO059_09635 ENOG4105CEY Amp-dependent synthetase and ligase FO059_09660 ENOG4108V3G Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) FO059_09665 ENOG4108BAS reductase FO059_09670 ENOG4107QUV Domain protein FO059_09680 ENOG4107SCA Formamidase (EC 3.5.1.49) FO059_09685 ENOG4105E39 Enoyl-CoA hydratase FO059_09690 ENOG4105CEY Amp-dependent synthetase and ligase FO059_09720 ENOG4105CUT histidyl-tRNA synthetase FO059_09725 ENOG4107VMB Beta-lactamase domain protein FO059_09735 ENOG4108ZR3 PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity) FO059_09740 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) FO059_09745 ENOG4109003 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity) FO059_09750 ENOG4108NY6 Extracellular solute-binding protein, family 5 FO059_09755 ENOG4107RTU Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) FO059_09765 ENOG4105ZCJ preprotein translocase subunit yajC FO059_09770 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) FO059_09775 ENOG4105KA4 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity) FO059_09780 ENOG4105NHU Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group (By similarity) FO059_09785 ENOG4105CDY transcriptional regulatory protein FO059_09790 ENOG4108UHX Involved in the hydrolysis of glutamine to glutamate and ammonia. Channels an ammonia molecule to PdxS (By similarity) FO059_09795 ENOG4105C29 acyl-CoA thioesterase FO059_09800 ENOG4105CD9 Involved in the production of pyridoxal phosphate, probably by incorporating ammonia into the pyridine ring (By similarity) FO059_09805 ENOG41062IR nudix hydrolase FO059_09810 ENOG4105E2K Glycosyl transferase (Group 1 FO059_09815 ENOG4107YQ3 lipid a biosynthesis lauroyl acyltransferase FO059_09830 ENOG4105C22 threonyL-tRNA synthetase FO059_09880 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) FO059_09890 ENOG4107P0T Selenium-dependent molybdenum hydroxylase system protein, YqeB family FO059_09935 ENOG4108P2G integral membrane protein FO059_09940 ENOG4105E0X reductase FO059_09945 ENOG4107JTW chlorite dismutase FO059_09950 ENOG4105C1Q protoporphyrinogen oxidase FO059_09955 ENOG4105CFZ Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) FO059_09980 ENOG4105C2V Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) FO059_09985 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) FO059_09990 ENOG4105C0X amino acid FO059_09995 ENOG4107VEG TrkA-N domain protein FO059_10025 ENOG4107ZFB This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) FO059_10060 ENOG4107S91 Sodium hydrogen exchanger FO059_10165 ENOG4105C5Q Transcriptional regulator FO059_10200 ENOG4105C2J ABC transporter FO059_10205 ENOG4108RVA ribokinase FO059_10210 ENOG4105CQ7 ATP-dependent helicase FO059_10215 ENOG4108Z11 Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity) FO059_10225 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) FO059_10235 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) FO059_10240 ENOG4105E4Z Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity) FO059_10245 ENOG4107QP3 malate synthase g FO059_10250 ENOG4107258 Transcriptional regulator FO059_10255 ENOG4105DKX Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) FO059_10265 ENOG4105C99 atpase involved in dna repair FO059_10275 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) FO059_10280 ENOG4105CDA abc transporter atp-binding protein FO059_10285 ENOG4107UBR Extracellular solute-binding protein family 3 FO059_10290 ENOG4108Q1T ABC transporter FO059_10295 ENOG4105DRP amino acid AbC transporter FO059_10300 ENOG4105KC9 Modulates RecA activity (By similarity) FO059_10305 ENOG4105C68 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity) FO059_10320 ENOG4107ZYJ bioY protein FO059_10325 ENOG4108JJB ABC transporter FO059_10330 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) FO059_10340 ENOG4105WBV Transcriptional regulator FO059_10345 ENOG4105CEV competence damage-inducible protein FO059_10365 ENOG4107QZI cell division protein FtsK FO059_10370 ENOG4105CN5 Metallo-Beta-Lactamase FO059_10375 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) FO059_10380 ENOG4107SMJ Catalyzes the formation of dTMP and tetrahydrofolate from dUMP and methylenetetrahydrofolate (By similarity) FO059_10400 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) FO059_10405 ENOG4105C1V Peptidase, M16 FO059_10410 ENOG4105C62 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) FO059_10415 ENOG4105K77 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity) FO059_10425 ENOG4107R5H iron (metal) dependent repressor, dtxr family FO059_10430 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) FO059_10445 ENOG4107QI1 Mate efflux family protein FO059_10450 ENOG4105SFS phosphoesterase RecJ domain protein FO059_10455 ENOG4107ZPY Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity) FO059_10460 ENOG4107QHU One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) FO059_10470 ENOG4105CHV Transcription elongation factor NusA FO059_10475 ENOG4107Z1I Required for maturation of 30S ribosomal subunits (By similarity) FO059_10490 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) FO059_10495 ENOG4107XFJ UPF0246 protein FO059_10500 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) FO059_10505 ENOG4105DWT malate dehydrogenase (quinone) FO059_10535 ENOG4105CRD Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity) FO059_10540 ENOG4105CJN penicillin-binding protein FO059_10550 ENOG4105C4E Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) FO059_10560 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) FO059_10565 ENOG41068X0 Protein of unknown function (DUF2631) FO059_10570 ENOG4105C55 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs FO059_10575 ENOG41060H3 Protein of unknown function (DUF1049) FO059_10585 ENOG4108VCV Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity) FO059_10590 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) FO059_10595 ENOG4105CU7 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity) FO059_10600 ENOG4105CE9 30S ribosomal protein S2 FO059_10610 ENOG4108IYT Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) FO059_10620 ENOG4105C0P Mg chelatase subunit ChlI FO059_10625 ENOG41080R2 UPF0102 protein FO059_10635 ENOG4108UH2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) FO059_10640 ENOG4107QYR Signal peptidase i FO059_10645 ENOG4108YY1 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity) FO059_10650 ENOG4105BZM domain protein FO059_10655 ENOG4105D6X Specifically methylates guanosine-37 in various tRNAs (By similarity) FO059_10660 ENOG4107XUM An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity) FO059_10670 ENOG4105K5M 30s ribosomal protein S16 FO059_10700 ENOG4105URP P-aminobenzoate N-oxygenase AurF FO059_10710 ENOG4108375 Acylphosphatase (EC 3.6.1.7) FO059_10730 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein FO059_10735 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) FO059_10745 ENOG4107Z6X Transcriptional regulator FO059_10765 ENOG4105VXP Protein of unknown function DUF86 FO059_10775 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) FO059_10780 ENOG4108ZBM Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity) FO059_10800 ENOG4108ZEF Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity) FO059_10805 ENOG4106H78 methyltransferase FO059_10810 ENOG4108JIJ Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second (By similarity) FO059_10815 ENOG4105CB5 ATP-dependent DNA helicase recG FO059_10820 ENOG4105DP4 dak2 domain fusion protein ylov FO059_10825 ENOG4105VB9 50S ribosomal protein l28 FO059_10830 ENOG4105D5S Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) FO059_10835 ENOG4108Z0R Transferase FO059_10850 ENOG4105CPF Cell wall formation (By similarity) FO059_10855 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase FO059_10860 ENOG4105ME0 Guanylyltransferase that catalyzes the activation of 2- phospho-L-lactate (LP) as (2S)-lactyl-2-diphospho-5'-guanosine (LPPG), via the condensation of LP with GTP. Is involved in the biosynthesis of coenzyme F420, a hydride carrier cofactor (By similarity) FO059_10865 ENOG4105CUU Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) FO059_10880 ENOG4105MQS Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) FO059_10885 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) FO059_10890 ENOG4107HP6 Transcriptional regulator FO059_10905 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) FO059_10910 ENOG4105CEY Amp-dependent synthetase and ligase FO059_10915 ENOG4105FBJ fumarylacetoacetate (faa) hydrolase FO059_10920 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) FO059_10935 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase FO059_10940 ENOG4108ZP8 Acetolactate synthase small subunit FO059_10955 ENOG4105C01 Dihydroxy-acid dehydratase FO059_10960 ENOG4108VGI doxx family FO059_10970 ENOG4105CHT Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) FO059_10985 ENOG4105WH1 Two component transcriptional regulator luxr family FO059_10990 ENOG4108ZGX Histidine kinase FO059_11005 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) FO059_11010 ENOG41081AP Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) FO059_11020 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) FO059_11030 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) FO059_11040 ENOG4105C10 Electron transfer flavoprotein FO059_11050 ENOG4108KQJ Type 11 methyltransferase FO059_11070 ENOG4105EVB acetyltransferase FO059_11100 ENOG4105DKW ABC transporter FO059_11105 ENOG4105C9C Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity) FO059_11125 ENOG4105CHU acetyl-coa acetyltransferase FO059_11150 ENOG4105F8J Adenylate Guanylate cyclase FO059_11160 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) FO059_11165 ENOG4108UVJ appr-1-p processing domain protein FO059_11180 ENOG4107QRT dEAD DEAH box helicase FO059_11205 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) FO059_11210 ENOG4108VX5 3-methyladenine DNA glycosylase FO059_11220 ENOG4105CH7 arginosuccinase FO059_11225 ENOG4105CDH Citrulline--aspartate ligase FO059_11235 ENOG4105DBV ornithine carbamoyltransferase FO059_11240 ENOG4105C8Y Acetylornithine aminotransferase FO059_11245 ENOG4105CAS nag kinase FO059_11250 ENOG4105C5V Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity) FO059_11255 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase FO059_11260 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) FO059_11265 ENOG4105CSS phenylalanyl-tRNA synthetase (alpha subunit) FO059_11275 ENOG4108YZX Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity) FO059_11280 ENOG41084BS 50S ribosomal protein L35 FO059_11295 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) FO059_11310 ENOG4105C5X domain protein FO059_11345 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) FO059_11355 ENOG4108HWB Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) FO059_11360 ENOG4108JEH abc transporter atp-binding protein FO059_11365 ENOG4105E5Q amino acid AbC transporter FO059_11370 ENOG4106PMH Extracellular solute-binding protein family 3 FO059_11385 ENOG4107S7E 1-acyl-sn-glycerol-3-phosphate acyltransferase FO059_11390 ENOG4105C8J )-transporter FO059_11420 ENOG4105CG1 Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity) FO059_11430 ENOG4108D32 Methyltransferase FO059_11435 ENOG4105DAB fumarate reductase succinate dehydrogenase flavoprotein domain protein FO059_11445 ENOG4105C29 acyl-CoA thioesterase FO059_11460 ENOG4107V6M Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity) FO059_11475 ENOG4105DK0 Indole-3-glycerol phosphate synthase FO059_11485 ENOG4105CRQ synthase (Component I) FO059_11500 ENOG4108KPJ rna polymerase sigma factor FO059_11505 ENOG4105MDH Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) FO059_11510 ENOG4108KE4 O-methyltransferase FO059_11520 ENOG4105C0S IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity) FO059_11525 ENOG4108MWI inositol mono-phosphatase FO059_11530 ENOG4105CJV Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase FO059_11540 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) FO059_11545 ENOG4105ECC imidazole-glycerol-phosphate dehydratase FO059_11550 ENOG4105CIH Imidazole acetol-phosphate transaminase FO059_11555 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) FO059_11560 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase FO059_11610 ENOG41066NP positive regulation by symbiont of host immune response FO059_11615 ENOG4105CZF Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity) FO059_11640 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein FO059_11650 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) FO059_11655 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) FO059_11680 ENOG4105C57 major facilitator superfamily FO059_11725 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) FO059_11745 ENOG4105VR5 Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA (By similarity) FO059_11755 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase FO059_11765 ENOG4105ME9 cell division protein FtsQ FO059_11770 ENOG4105DFU Cell wall formation (By similarity) FO059_11775 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) FO059_11785 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) FO059_11790 ENOG4105CPY First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) FO059_11805 ENOG4105CJN penicillin-binding protein FO059_11815 ENOG4105CGJ Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) FO059_11820 ENOG4108V6E Cell division protein mraZ FO059_11865 ENOG41090CE integral membrane protein FO059_11875 ENOG4105KYH transcriptional regulatory protein FO059_11885 ENOG4105C7V phospho-2-dehydro-3-deoxyheptonate aldolase FO059_11910 ENOG4105D0U Arsenite-activated ATPase (ArsA) FO059_11930 ENOG4105JNK Glycosyl transferase (Group 1 FO059_11960 ENOG4108I0Q anthranilate phosphoribosyltransferase FO059_11970 ENOG4105CCU oxidase (Subunit III) FO059_11990 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase FO059_11995 ENOG4108ZRS Part of cytochrome c oxidase, its function is FO059_12000 ENOG4105CV4 Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) (By similarity) FO059_12035 ENOG410813T Joins Ado-cobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin) (By similarity) FO059_12040 ENOG4105CM2 brancheD-chain amino acid aminotransferase FO059_12050 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) FO059_12070 ENOG4108BDP Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity) FO059_12075 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) FO059_12090 ENOG4105C5F glutamine synthetase FO059_12100 ENOG4105E90 ABC transporter FO059_12105 ENOG4108IJ8 ABC transporter FO059_12110 ENOG4105E90 ABC transporter FO059_12115 ENOG4107SI7 Substrate-binding region of abc-type glycine betaine transport system FO059_12125 ENOG4105CE6 Adenylation and deadenylation of glutamate--ammonia ligase (By similarity) FO059_12130 ENOG4105C5F glutamine synthetase FO059_12135 ENOG4105CCG Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity) FO059_12160 ENOG4105CVJ phosphoglycerate mutase FO059_12255 ENOG4105FQP Beta-lactamase FO059_12260 ENOG4105C0R drug resistance transporter emrb qaca subfamily FO059_12555 ENOG4105F9F transposase FO059_12560 ENOG4105D85 methylase FO059_12575 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) FO059_12580 ENOG4105C4Q deoxyguanosinetriphosphate triphosphohydrolase-like protein FO059_12595 ENOG4108UMN azlc family FO059_12600 ENOG4105KMT branched-chain amino acid FO059_12620 ENOG4105D9H Catalyzes the attachment of glycine to tRNA(Gly) (By similarity) FO059_12640 ENOG4105CSV Glutaminase FO059_12650 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) FO059_12655 ENOG4106DBE Involved in DNA repair and RecF pathway recombination (By similarity) FO059_12680 ENOG4107VNR Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) FO059_12695 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) FO059_12700 ENOG4105CI8 Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons (By similarity) FO059_12715 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) FO059_12720 ENOG4105ET3 Reduction of activated sulfate into sulfite (By similarity) FO059_12760 ENOG4105BZP glycoside hydrolase 15-related FO059_12765 ENOG4105EA8 2-Nitropropane dioxygenase FO059_12770 ENOG4105C4S Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) FO059_12775 ENOG4105KQV Binds directly to 16S ribosomal RNA (By similarity) FO059_12805 ENOG4105CVJ phosphoglycerate mutase FO059_12815 ENOG4108Z1W Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) FO059_12825 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit FO059_12830 ENOG4105C2S Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity) FO059_12835 ENOG4105EG6 Saccharopine dehydrogenase FO059_12840 ENOG4105C9U ATP-dependent DNA helicase RecQ FO059_12845 ENOG4108Z24 l-2,4-diaminobutyric acid acetyltransferase FO059_12850 ENOG4108JPW Aminotransferase FO059_12855 ENOG4108Z6K Catalyzes the circularization of gamma-N-acetyl- alpha,gamma-diaminobutyric acid (ADABA) to ectoine (1,4,5,6- tetrahydro-2-methyl-4-pyrimidine carboxylic acid), which is an excellent osmoprotectant (By similarity) FO059_12870 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) FO059_12875 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control FO059_12880 ENOG4105K46 50S ribosomal protein l27 FO059_12885 ENOG410826X This protein binds to 23S rRNA in the presence of protein L20 (By similarity) FO059_12890 ENOG4105C03 ribonuclease FO059_12890 ENOG4105C03 ribonuclease FO059_12895 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) FO059_12905 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase FO059_12910 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) FO059_12935 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) FO059_12955 ENOG41074FZ May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity) FO059_12960 ENOG4107HP6 Transcriptional regulator FO059_12965 ENOG4105CHN ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) FO059_12970 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) FO059_12975 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) FO059_12980 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation FO059_13035 ENOG4105MC2 DSBA oxidoreductase FO059_13040 ENOG4108XW1 Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity (By similarity) FO059_13080 ENOG4105C7I Dehydrogenase FO059_13125 ENOG4105EV8 ectoine hydroxylase FO059_13135 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase FO059_13160 ENOG4108RBP 3'-to-5' exoribonuclease specific for small oligoribonucleotides (By similarity) FO059_13215 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) FO059_13230 ENOG4105WH1 Two component transcriptional regulator luxr family FO059_13245 ENOG4105IBS Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity) FO059_13250 ENOG4108F01 MaoC domain protein FO059_13255 ENOG4105C57 major facilitator superfamily FO059_13325 ENOG4108IYT Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) FO059_13350 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) FO059_13355 ENOG4105ED0 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity) FO059_13385 ENOG4105KEN Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation (By similarity) FO059_13390 ENOG4107RKP Nicotinate phosphoribosyltransferase FO059_13395 ENOG4108RWI nicotinamidase FO059_13415 ENOG4105BZ9 Cytochrome C oxidase, subunit I FO059_13440 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) FO059_13450 ENOG4105G3E Probably involved in ribonucleotide reductase function (By similarity) FO059_13460 ENOG4105E5G Alpha beta hydrolase fold FO059_13475 ENOG4107RA1 nh(3)-dependent nad( ) synthetase FO059_13480 ENOG4105CZN Potassium uptake protein FO059_13485 ENOG4107ZYR domain protein FO059_13490 ENOG4108KB2 LysR family Transcriptional regulator FO059_13510 ENOG4108KPJ rna polymerase sigma factor FO059_13550 ENOG4108UH4 Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity) FO059_13555 ENOG4107RYD Part of the ABC transporter FtsEX involved in cellular division (By similarity) FO059_13560 ENOG4105CAK Cell division ATP-binding protein ftsE FO059_13565 ENOG4105CG1 Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity) FO059_13570 ENOG4107TK4 histidinol-phosphate phosphatase FO059_13580 ENOG41062D9 Histidine kinase FO059_13600 ENOG4105C1G acyl-Coa dehydrogenase FO059_13605 ENOG4105C1G acyl-Coa dehydrogenase FO059_13615 ENOG4105CEY Amp-dependent synthetase and ligase FO059_13635 ENOG4105DJZ UPF0182 protein FO059_13645 ENOG41063PX domain protein FO059_13685 ENOG4107SVH Potassium channel protein FO059_13690 ENOG4105C4R Atp-dependent dna helicase FO059_13700 ENOG4108YIQ Alpha beta hydrolase FO059_13715 ENOG4105JXH GntR family transcriptional regulator FO059_13755 ENOG4105C1J atp-dependent rna helicase FO059_13770 ENOG4108ZM9 phosphoglycerate mutase FO059_13790 ENOG4105CBD Diacylglycerol kinase FO059_13820 ENOG4108Z66 YbaK ebsC protein FO059_13825 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase FO059_13830 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) FO059_13835 ENOG4106A3M Cytochrome p-450 FO059_13840 ENOG4105F2C Acetyl-CoA acetyltransferase FO059_13850 ENOG4105KF3 Short-chain dehydrogenase reductase Sdr FO059_13855 ENOG4105E39 Enoyl-CoA hydratase FO059_13870 ENOG4105EA8 2-Nitropropane dioxygenase FO059_13875 ENOG4106JDR secreted FO059_13880 ENOG4105F2C Acetyl-CoA acetyltransferase FO059_13885 ENOG4108RZE Tetr family transcriptional regulator FO059_13890 ENOG4105CHR reductase FO059_13895 ENOG4105CC9 acyl-Coa dehydrogenase FO059_13900 ENOG4105CEY Amp-dependent synthetase and ligase FO059_13905 ENOG4105CC9 acyl-Coa dehydrogenase FO059_13910 ENOG4105D2B acyl-CoA dehydrogenase FO059_13915 ENOG4105D2B acyl-CoA dehydrogenase FO059_13940 ENOG4105DTQ mandelate racemase muconate lactonizing FO059_13945 ENOG4108QMY dioxygenase FO059_13950 ENOG4107HP6 Transcriptional regulator FO059_13955 ENOG4107RSM transcriptional regulator FO059_13985 ENOG4108JA0 Oxidoreductase, FAD NAD(P)-binding domain protein FO059_13990 ENOG4106NZI LysR family Transcriptional regulator FO059_14000 ENOG4105MXW flavin reductase domain protein, FMN-binding FO059_14005 ENOG4105H37 Glyoxalase Bleomycin resistance protein (Dioxygenase FO059_14010 ENOG4108KC1 acyl-Coa dehydrogenase FO059_14025 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) FO059_14035 ENOG4108M9J MaoC like domain protein FO059_14045 ENOG4105DAB fumarate reductase succinate dehydrogenase flavoprotein domain protein FO059_14065 ENOG410635A Membrane FO059_14095 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) FO059_14130 ENOG410900P UPF0336 protein FO059_14135 ENOG4105X7H acyl-CoA dehydrogenase FO059_14140 ENOG4108RK3 acyl-Coa dehydrogenase FO059_14145 ENOG4105D2B acyl-CoA dehydrogenase FO059_14150 ENOG4108SGK Tetr family transcriptional regulator FO059_14155 ENOG4105BZP glycoside hydrolase 15-related FO059_14160 ENOG4105DSE periplasmic solute binding protein FO059_14165 ENOG4105DIK (ABC) transporter FO059_14170 ENOG4105CC5 ABC transporter FO059_14185 ENOG4105P4J Allophanate hydrolase, subunit 1 FO059_14210 ENOG4105D52 delta-aminolevulinic acid dehydratase FO059_14220 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) FO059_14225 ENOG4105C7E Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity) FO059_14235 ENOG4108RXW HAD-superfamily subfamily IB hydrolase FO059_14270 ENOG41063NU Membrane FO059_14290 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FO059_14300 ENOG4107RPC Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) FO059_14305 ENOG4108YZJ Pfam:DUF2596 FO059_14310 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) FO059_14325 ENOG4107R4N Cell wall formation (By similarity) FO059_14340 ENOG4105FCI Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity) FO059_14375 ENOG4106BRA Membrane FO059_14420 ENOG4108R85 Short chain dehydrogenase FO059_14500 ENOG4107XM9 (LipO)protein FO059_14510 ENOG4105H3G oxidoreductase FO059_14515 ENOG4105CYX Short-chain dehydrogenase reductase Sdr FO059_14540 ENOG4105DRC Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) FO059_14580 ENOG4105K6V RNA polymerase FO059_14595 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase FO059_14600 ENOG4105WH1 Two component transcriptional regulator luxr family FO059_14635 ENOG4105CVP deoxyribo-dipyrimidine photolyase FO059_14640 ENOG4107YB1 Trehalose corynomycolyl transferase FO059_14645 ENOG4105D8T Acyltransferase FO059_14655 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) FO059_14675 ENOG4105D4U had-superfamily hydrolase, subfamily iia FO059_14725 ENOG41071I4 Phosphatidylserine decarboxylase proenzyme FO059_14785 ENOG4105EC2 ftsk spoIIIe FO059_14795 ENOG41090GG peptidase S8 and S53, subtilisin, kexin, sedolisin FO059_14825 ENOG4105D65 subunit l FO059_14830 ENOG4105MKQ Monovalent cation H antiporter subunit C FO059_14835 ENOG4108JPZ Monovalent cation H antiporter subunit D FO059_14855 ENOG4106KXD ATP-dependent carboxylate-amine ligase (By similarity) FO059_14875 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) FO059_14925 ENOG4105CBF Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity) FO059_14930 ENOG4105DWF phosphomethylpyrimidine kinase FO059_14955 ENOG4105CA8 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity) FO059_14975 ENOG4105D74 hydrolase FO059_14990 ENOG4105CT1 (ABC) transporter FO059_14995 ENOG4107Q25 Serine Threonine protein kinase FO059_15005 ENOG4105DYW oxidoreductase FO059_15015 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) FO059_15025 ENOG41079Y2 Catalyzes the coenzyme F420-dependent oxidation of glucose 6-phosphate (G6P) to 6-phosphogluconolactone FO059_15030 ENOG4105CHR reductase FO059_15035 ENOG4105DYW oxidoreductase FO059_15045 ENOG4108YZT Adenosylcobinamide kinase FO059_15055 ENOG4105EHG Permease protein FO059_15060 ENOG4105JKQ Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity) FO059_15085 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F FO059_15090 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase FO059_15105 ENOG4105WQI isochorismatase FO059_15110 ENOG4105E4F Isochorismate synthase FO059_15115 ENOG4105X17 23-dihydro-2,3-dihydroxybenzoate dehydrogenase FO059_15120 ENOG4105E93 esterase FO059_15125 ENOG4105E0A ABC, transporter FO059_15130 ENOG4108IHU transport system permease protein FO059_15135 ENOG4105DQ5 transport system permease protein FO059_15145 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase FO059_15150 ENOG4105WQI isochorismatase FO059_15155 ENOG4105CEY Amp-dependent synthetase and ligase FO059_15160 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis FO059_15170 ENOG4107XZ0 Peptidase M50 FO059_15180 ENOG4105PGM cation diffusion facilitator family transporter FO059_15185 ENOG4105K4H Nlp p60 protein FO059_15220 ENOG4106A3M Cytochrome p-450 FO059_15225 ENOG4105CHR reductase FO059_15230 ENOG4105C26 Dehydrogenase FO059_15260 ENOG4105CEY Amp-dependent synthetase and ligase FO059_15270 ENOG4108SGK Tetr family transcriptional regulator FO059_15275 ENOG4107S2E monooxygenase FO059_15315 ENOG4105DQ5 transport system permease protein FO059_15320 ENOG4105TVJ transport system, permease FO059_15325 ENOG4105E0A ABC, transporter FO059_15350 ENOG4105DQR SNARE associated Golgi FO059_15405 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit FO059_15415 ENOG4105CEY Amp-dependent synthetase and ligase FO059_15450 ENOG4105KNI merR family transcriptional Regulator FO059_15455 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) FO059_15460 ENOG4108093 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ FO059_15465 ENOG4105CFG Acts as a chaperone (By similarity) FO059_15480 ENOG4105DF6 Fe-S oxidoreductase FO059_15485 ENOG4105WH1 Two component transcriptional regulator luxr family FO059_15500 ENOG4105CJ1 ABC, transporter FO059_15515 ENOG4108K81 inner membrane protein YghB FO059_15530 ENOG4105DHP deoxycytidine triphosphate deaminase FO059_15560 ENOG4105CV8 reductase FO059_15575 ENOG4105KRQ Addiction module toxin, Txe YoeB family FO059_15580 ENOG4105VTW prevent-host-death family FO059_15595 ENOG4105CHF Glutathione S-transferase FO059_15600 ENOG41088CC tellurite resistance protein tehB FO059_15605 ENOG4105CSU acyl-Coa dehydrogenase FO059_15610 ENOG4105C2J ABC transporter FO059_15640 ENOG4105URP P-aminobenzoate N-oxygenase AurF FO059_15645 ENOG4105CHU acetyl-coa acetyltransferase FO059_15650 ENOG4105CHR reductase FO059_15665 ENOG4105D17 glycoside hydrolase, family 3 domain protein FO059_15685 ENOG41073B4 coagulation factor 5 8 type domain-containing protein FO059_15725 ENOG4108M6P methyltransferase FO059_15745 ENOG4108UKI Enoyl-CoA hydratase FO059_15750 ENOG4105EUB pirin domain protein FO059_15755 ENOG4105C0M Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle (By similarity) FO059_15760 ENOG4108HGY Proline imino-peptidase FO059_15780 ENOG4105CZ1 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) FO059_15790 ENOG4107R13 MMPL domain protein FO059_15795 ENOG4105F8J Adenylate Guanylate cyclase FO059_15805 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) FO059_15810 ENOG4105DMF Dehydrogenase FO059_15815 ENOG4105K5B UPF0225 protein FO059_15820 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase FO059_15855 ENOG4108YYC ycei family FO059_15865 ENOG4105DUX Transporter FO059_15870 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase FO059_15880 ENOG4107MII Sugar-specific transcriptional regulator TrmB FO059_15890 ENOG4107ZR7 Membrane FO059_15905 ENOG4105C28 cystathionine FO059_15910 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase FO059_15925 ENOG4105C9K Endothelin-converting enzyme 1 FO059_15930 ENOG4105F9E Shikimate 5-dehydrogenase FO059_15970 ENOG4105CQB FAD linked oxidase domain protein FO059_15975 ENOG41080RH Thioredoxin FO059_15980 ENOG4105C01 Dihydroxy-acid dehydratase FO059_15990 ENOG4108QER Adenylate cyclase FO059_16005 ENOG4108UMW Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) FO059_16015 ENOG41080V3 Major Facilitator superfamily FO059_16020 ENOG4108Z67 carbohydrate kinase, thermoresistant glucokinase family FO059_16045 ENOG4107YB1 Trehalose corynomycolyl transferase FO059_16055 ENOG4105C1G acyl-Coa dehydrogenase FO059_16060 ENOG4105CEY Amp-dependent synthetase and ligase FO059_16065 ENOG4105CHR reductase FO059_16070 ENOG4108UKI Enoyl-CoA hydratase FO059_16085 ENOG4105C1G acyl-Coa dehydrogenase FO059_16115 ENOG4108VWQ crispr-associated protein FO059_16125 ENOG4105TZK CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. May be involved in the integration of spacer DNA into the CRISPR cassette (By similarity) FO059_16150 ENOG4108RPX mosc domain containing protein FO059_16155 ENOG4105EXU Membrane FO059_16170 ENOG4105DSF transport protein FO059_16175 ENOG4107QJZ Glycosyl transferase, family 2 FO059_16190 ENOG4105EUZ Beta-lactamase domain protein FO059_16195 ENOG41086KC Transcriptional regulator FO059_16245 ENOG4105C1G acyl-Coa dehydrogenase FO059_16250 ENOG4108Z4U Ferredoxin FO059_16260 ENOG4107WI4 Aldose-1-epimerase FO059_16265 ENOG4105CPC Aldo Keto reductase FO059_16280 ENOG4105C57 major facilitator superfamily FO059_16325 ENOG4105C1B dTDP-glucose 4-6-dehydratase FO059_16335 ENOG4105CSU acyl-Coa dehydrogenase FO059_16340 ENOG4105MXW flavin reductase domain protein, FMN-binding FO059_16355 ENOG41079Y2 Catalyzes the coenzyme F420-dependent oxidation of glucose 6-phosphate (G6P) to 6-phosphogluconolactone FO059_16370 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase FO059_16385 ENOG4105H37 Glyoxalase Bleomycin resistance protein (Dioxygenase FO059_16395 ENOG4107FW0 short-chain dehydrogenase reductase FO059_16400 ENOG4105CV8 reductase FO059_16405 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) FO059_16410 ENOG4106HK8 GPR1 FUN34 yaaH family protein FO059_16425 ENOG4105CEY Amp-dependent synthetase and ligase FO059_16440 ENOG4108JQ7 (ABC) transporter FO059_16475 ENOG4105CEY Amp-dependent synthetase and ligase FO059_16490 ENOG4105CJX Molecular chaperone. Has ATPase activity (By similarity) FO059_16525 ENOG4105EJ2 Transcriptional regulator FO059_16540 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) FO059_16545 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) FO059_16580 ENOG4106A3M Cytochrome p-450 FO059_16600 ENOG41068W2 Cytochrome p-450 FO059_16715 ENOG4105CJ1 ABC, transporter FO059_16725 ENOG4105PP6 Membrane FO059_16730 ENOG4108ZJ4 polysaccharide deacetylase FO059_16740 ENOG4108ZGX Histidine kinase FO059_16745 ENOG4105WH1 Two component transcriptional regulator luxr family FO059_16750 ENOG4105CV2 Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates (By similarity) FO059_16765 ENOG41080V3 Major Facilitator superfamily FO059_16775 ENOG4107QR9 Iron-sulfur cluster binding protein FO059_16780 ENOG41080R8 Conserved Protein FO059_16845 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) FO059_16855 ENOG410901E Membrane FO059_16860 ENOG4105MWK D-amino acid dehydrogenase, small subunit FO059_16870 ENOG4105CEP NADH dehydrogenase FO059_16885 ENOG4105CSH Transporter FO059_16890 ENOG4105C0R drug resistance transporter emrb qaca subfamily FO059_16900 ENOG4105KHC sulfurtransferase FO059_16915 ENOG4108NJC FO059_16925 ENOG4107QWP ABC-2 type transporter FO059_17025 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) FO059_17055 ENOG4105F9F transposase FO059_17060 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein FO059_17075 ENOG4105EBR Carboxylesterase FO059_17090 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase FO059_17110 ENOG4108R85 Short chain dehydrogenase FO059_17115 ENOG4105CSU acyl-Coa dehydrogenase FO059_17135 ENOG4105PAD Hydrolase FO059_17140 ENOG41082VC UPF0145 protein FO059_17150 ENOG4108UZX fmn reductase FO059_17175 ENOG4105BZN citrate synthase FO059_17180 ENOG4105CR4 methylisocitrate lyase FO059_17215 ENOG4107RFD Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) FO059_17220 ENOG4105D82 Glutamate dehydrogenase FO059_17225 ENOG4108JPW Aminotransferase FO059_17230 ENOG4105DRR Transcriptional regulator, GntR family FO059_17240 ENOG4105DV0 amidase (EC 3.5.1.4 FO059_17250 ENOG4105DBE peroxidase FO059_17255 ENOG410650H (LipO)protein FO059_17265 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase FO059_17270 ENOG4105CJN penicillin-binding protein FO059_17280 ENOG4105DDW LysR family Transcriptional regulator FO059_17305 ENOG4105E7Q Cob(II)yrinic acid a,c-diamide reductase FO059_17325 ENOG4107EFR Flavocytochrome c FO059_17340 ENOG4105CR5 Class II aldolase adducin family protein FO059_17370 ENOG4107QQG Dehydrogenase FO059_17375 ENOG4107QJZ Glycosyl transferase, family 2 FO059_17405 ENOG4105CPC Aldo Keto reductase FO059_17435 ENOG4107QPD alcohol dehydrogenase FO059_17445 ENOG4105CC9 acyl-Coa dehydrogenase FO059_17485 ENOG4105F2C Acetyl-CoA acetyltransferase FO059_17490 ENOG4105D2B acyl-CoA dehydrogenase FO059_17495 ENOG4105CEY Amp-dependent synthetase and ligase FO059_17505 ENOG4105X7H acyl-CoA dehydrogenase FO059_17515 ENOG4105J5T Amp-dependent synthetase and ligase FO059_17520 ENOG410900P UPF0336 protein FO059_17545 ENOG4107ZQV short-chain dehydrogenase reductase FO059_17570 ENOG4105EWI Short-chain dehydrogenase reductase Sdr FO059_17580 ENOG41079Y2 Catalyzes the coenzyme F420-dependent oxidation of glucose 6-phosphate (G6P) to 6-phosphogluconolactone FO059_17590 ENOG4105CHR reductase FO059_17620 ENOG4105K9Q Binds to the 23S rRNA (By similarity) FO059_17625 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) FO059_17635 ENOG410829C Binds together with S18 to 16S ribosomal RNA (By similarity) FO059_17665 ENOG4108RU2 n-acetylmuramoyl-l-alanine amidase FO059_17670 ENOG4108ZR3 PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity) FO059_17680 ENOG4105BZ4 penicillin-binding protein FO059_17690 ENOG4105VUN Transcriptional regulator FO059_17695 ENOG4105CZA synthase FO059_17760 ENOG4108K7T Involved in the biosynthesis of the arabinogalactan (AG) region of the mycolylarabinogalactan-peptidoglycan (mAGP) complex, an essential component the mycobacterial cell wall. Catalyzes the addition of the first key arabinofuranosyl (Araf) residue from the sugar donor beta-D-arabinofuranosyl-1-monophosphoryldecaprenol (DPA) on the C-5 of a 6-linked galactofuranosyl (Galf) of the galactan domain, thus 'priming' the galactan for further elaboration by other arabinofuranosyltransferases FO059_17770 ENOG4108EMS branched-chain alpha-keto acid dehydrogenase subunit E2 FO059_17775 ENOG4108T3F Repressor of the marRAB operon which is involved in the activation of both antibiotic resistance and oxidative stress genes FO059_17780 ENOG4105DXB Major Facilitator superfamily FO059_17785 ENOG4105MXW flavin reductase domain protein, FMN-binding FO059_17790 ENOG4105EMU Dehydrogenase FO059_17820 ENOG4105C8T Leucyl-tRNA synthetase FO059_17830 ENOG4105DHU Bile acid FO059_17840 ENOG41081DT UPF0301 protein FO059_17855 ENOG4105D4J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate FO059_17885 ENOG4105C3M thioredoxin reductase FO059_17890 ENOG4105K63 Thioredoxin FO059_17895 ENOG4108E1C hydrolase FO059_17910 ENOG4107QJE Chromosome Partitioning Protein FO059_17915 ENOG4107XUG Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity) FO059_17925 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins FO059_17930 ENOG4105VAS Could be involved in insertion of integral membrane proteins into the membrane (By similarity) FO059_17935 ENOG4105XH8 RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity) FO059_18085 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F FO059_18100 ENOG4105E2B Taurine dioxygenase FO059_18110 ENOG4105E39 Enoyl-CoA hydratase