locus-tag	class	description
HG537_0A00150	ENOG4105C54	Major Facilitator superfamily
HG537_0A00160	ENOG4105ENN	converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity)
HG537_0A00240	ENOG4105BZ5	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity)
HG537_0A00300	ENOG4108JJA	ABC, transporter
HG537_0A00400	ENOG4108JJ7	ABC transporter
HG537_0A00410	ENOG4105CBA	glutamine phosphoribosylpyrophosphate amidotransferase
HG537_0A00480	ENOG4107EEK	Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity)
HG537_0A00530	ENOG4105C3P	Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity)
HG537_0A00570	ENOG4105EUJ	GTP cyclohydrolase i
HG537_0A00580	ENOG4105D9P	serine threonine protein kinase
HG537_0A00610	ENOG4105CKH	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity)
HG537_0A00740	ENOG4105C7Q	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity)
HG537_0A00770	ENOG4105CCY	NADH flavin oxidoreductase, NADH oxidase
HG537_0A00810	ENOG4105C70	Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity)
HG537_0A00890	ENOG4105C9R	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
HG537_0A01010	ENOG4105CMV	Succinyl-CoA synthetase subunit beta
HG537_0A01040	ENOG4105CTQ	phosphohexokinase
HG537_0A01120	ENOG4105CJJ	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity)
HG537_0A01290	ENOG4105EEE	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity)
HG537_0A01360	ENOG4105C1J	atp-dependent rna helicase
HG537_0A01530	ENOG4105F91	Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity)
HG537_0A01580	ENOG4105D1F	ATP-binding protein
HG537_0A01720	ENOG4105E33	succinate dehydrogenase
HG537_0A01750	ENOG4105D8C	Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity)
HG537_0A01760	ENOG4107QVN	Key enzyme in the regulation of glycerol uptake and metabolism (By similarity)
HG537_0A01940	ENOG4105KAP	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity)
HG537_0A02260	ENOG4105C0C	Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity)
HG537_0A02270	ENOG4105CYJ	ribosomal RNA small subunit methyltransferase B
HG537_0A02280	ENOG4105DGU	Histone deacetylase
HG537_0A02290	ENOG4105D9P	serine threonine protein kinase
HG537_0A02330	ENOG4106B21	frataxin-like protein
HG537_0A02450	ENOG4108R5J	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity)
HG537_0A02470	ENOG4105DTD	Dehydrogenase
HG537_0A02490	ENOG4105FE8	tRNA (Guanosine-2'-O-)-methyltransferase
HG537_0A02550	ENOG4105C8K	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity)
HG537_0A02630	ENOG4105C26	Dehydrogenase
HG537_0A02650	ENOG4105DC6	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity)
HG537_0A02670	ENOG4105CPM	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity)
HG537_0A02720	ENOG4108MYC	UTP-glucose-1-phosphate uridylyltransferase
HG537_0A02740	ENOG4105BZ5	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity)
HG537_0A02760	ENOG4108QVN	serine threonine protein kinase
HG537_0A02800	ENOG4105D0U	Arsenite-activated ATPase (ArsA)
HG537_0A03070	ENOG4105C1J	atp-dependent rna helicase
HG537_0A03130	ENOG4108JPX	Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity)
HG537_0A03140	ENOG4107RA9	decarboxylase
HG537_0A03160	ENOG4105C80	Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity)
HG537_0A03310	ENOG4105DC6	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity)
HG537_0A03350	ENOG4105CQ7	ATP-dependent helicase
HG537_0A03460	ENOG4105CGF	Aromatic amino acid aminotransferase
HG537_0A03620	ENOG4105DPM	folylpolyglutamate synthase Dihydrofolate synthase
HG537_0A03670	ENOG4105C7K	acetolactate synthase
HG537_0A03710	ENOG4107QIX	Phosphoglucomutase (EC 5.4.2.2
HG537_0A03720	ENOG4105D9P	serine threonine protein kinase
HG537_0A03780	ENOG4105CR3	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity)
HG537_0A03840	ENOG4105EFU	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin (By similarity)
HG537_0A03850	ENOG4105C2M	dna polymerase I
HG537_0A03890	ENOG4105C9W	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity)
HG537_0A03910	ENOG4105CD9	Involved in the production of pyridoxal phosphate, probably by incorporating ammonia into the pyridine ring (By similarity)
HG537_0A03920	ENOG4108UHX	Involved in the hydrolysis of glutamine to glutamate and ammonia. Channels an ammonia molecule to PdxS (By similarity)
HG537_0A03980	ENOG4105C3H	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity)
HG537_0A03990	ENOG4105C0R	drug resistance transporter emrb qaca subfamily
HG537_0A04000	ENOG4108UVJ	appr-1-p processing domain protein
HG537_0A04010	ENOG4105CGF	Aromatic amino acid aminotransferase
HG537_0A04030	ENOG4105C46	Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity)
HG537_0A04040	ENOG4105DFM	M18 family aminopeptidase
HG537_0A04050	ENOG4105D9P	serine threonine protein kinase
HG537_0A04120	ENOG4105D1H	recombination factor protein RarA
HG537_0A04360	ENOG4108I67	Catalyzes the synthesis of activated sulfate (By similarity)
HG537_0A04480	ENOG4105KF3	Short-chain dehydrogenase reductase Sdr
HG537_0A04540	ENOG4105CUZ	uba thif-type nad fad binding protein
HG537_0A04560	ENOG4105C6K	Malic enzyme
HG537_0A04670	ENOG4105TMB	Formate nitrite transporter
HG537_0A04710	ENOG4105C5T	Phosphoribosyl pyrophosphate synthase
HG537_0A04840	ENOG4107QNK	)-transporter
HG537_0A04870	ENOG4105CUZ	uba thif-type nad fad binding protein
HG537_0A04880	ENOG4105C0C	Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity)
HG537_0A04930	ENOG4105CH8	Succinyl-CoA ligase ADP-forming subunit alpha
HG537_0A05120	ENOG4108IIJ	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
HG537_0A05150	ENOG4105IDI	abc transporter atp-binding protein
HG537_0A05220	ENOG4105KPK	Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation (By similarity)
HG537_0A05230	ENOG4108V3E	phosphoribosylglycinamide formyltransferase
HG537_0A05310	ENOG4105CFD	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
HG537_0A05330	ENOG4105M56	Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity)
HG537_0A05350	ENOG4105D6Z	AFG1 family ATPase
HG537_0A05510	ENOG4105W0E	50S ribosomal protein L33
HG537_0A05620	ENOG4105DDT	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity)
HG537_0A05710	ENOG4109003	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity)
HG537_0A05760	ENOG4107QNK	)-transporter
HG537_0A05880	ENOG4108UHA	Essential for recycling GMP and indirectly, cGMP (By similarity)
HG537_0A06080	ENOG4105CK4	Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity)
HG537_0A06100	ENOG4105MWK	D-amino acid dehydrogenase, small subunit
HG537_0A06150	ENOG4105CGR	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity)
HG537_0A06240	ENOG4105K5Y	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity)
HG537_0A06300	ENOG4105NDF	NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity)
HG537_0A06360	ENOG4105C2Z	ATP-dependent CLP protease ATP-binding subunit
HG537_0A06400	ENOG4105CQP	nitrilase cyanide hydratase and apolipoprotein n-acyltransferase
HG537_0A06440	ENOG4105K9H	YciI-like protein
HG537_0A06540	ENOG4105JD4	ATPase yjob
HG537_0A06610	ENOG4105CY8	phosphoribosylaminoimidazole carboxylase atpase subunit
HG537_0A06620	ENOG4107RA9	decarboxylase
HG537_0A06680	ENOG4105C40	3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity)
HG537_0A06690	ENOG4105C5H	ABC transporter
HG537_0A06710	ENOG4107QHU	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity)
HG537_0A06790	ENOG4105CEP	NADH dehydrogenase
HG537_0A06830	ENOG4105CH7	arginosuccinase
HG537_0A06840	ENOG4105C5S	asparaginyl-tRNA synthetase
HG537_0A06850	ENOG4105C90	Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity)
HG537_0A06900	ENOG4105DF9	Lipoate-protein, ligase
HG537_0A06980	ENOG4105C65	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity)
HG537_0A06990	ENOG4105C4S	Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity)
HG537_0A07090	ENOG4108URH	decarboxylase
HG537_0A07120	ENOG4107QPV	Serine Threonine protein kinase
HG537_0A07150	ENOG4105CHM	Aminotransferase
HG537_0A07210	ENOG4107EXU	Short-chain dehydrogenase reductase Sdr
HG537_0A07230	ENOG4108ZT0	50S ribosomal protein l17
HG537_0A07600	ENOG4105DBV	ornithine carbamoyltransferase
HG537_0A07670	ENOG4105D9P	serine threonine protein kinase
HG537_0A07680	ENOG4105KK9	This protein binds to 23S rRNA in the presence of protein L20 (By similarity)
HG537_0A07730	ENOG4105CPM	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity)
HG537_0A07760	ENOG4105CJ9	Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity)
HG537_0A07840	ENOG4105D9P	serine threonine protein kinase
HG537_0A07890	ENOG4105C1J	atp-dependent rna helicase
HG537_0A07910	ENOG4105C35	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity)
HG537_0A07920	ENOG4105CEJ	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity)
HG537_0A08020	ENOG4105DJV	ribulose-phosphate 3-epimerase
HG537_0A08130	ENOG4105CU6	carbamoyl-phosphate synthetase ammonia chain
HG537_0A08220	ENOG4105BZT	Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity)
HG537_0A08290	ENOG4105D9P	serine threonine protein kinase
HG537_0A08310	ENOG4105CZF	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity)
HG537_0A08530	ENOG4105C4J	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity)
HG537_0A08550	ENOG4108UHY	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity)
HG537_0A08570	ENOG4105DP8	Major facilitator superfamily MFS_1
HG537_0A08590	ENOG4105EM7	Selenocysteine-specific translation elongation factor
HG537_0A08610	ENOG4105D9P	serine threonine protein kinase
HG537_0A08680	ENOG41082AF	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity)
HG537_0A08690	ENOG4105ET3	Reduction of activated sulfate into sulfite (By similarity)
HG537_0A08990	ENOG4105IQJ	Involved in biosynthesis of the thiamine precursor thiazole (By similarity)
HG537_0A09020	ENOG4105CHR	reductase
HG537_0A09030	ENOG4108UW5	maltose o-acetyltransferase
HG537_0A09040	ENOG4105CKI	cobalamin synthesis protein
HG537_0A09090	ENOG4107SET	aldo keto reductase
HG537_0B00150	ENOG4105E2B	Taurine dioxygenase
HG537_0B00180	ENOG4105CCY	NADH flavin oxidoreductase, NADH oxidase
HG537_0B00310	ENOG4105F7M	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit (By similarity)
HG537_0B00460	ENOG4108V1T	peptidylprolyl cis-trans isomerase
HG537_0B00490	ENOG4105K63	Thioredoxin
HG537_0B00590	ENOG4105E0X	reductase
HG537_0B00640	ENOG4105CEK	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity)
HG537_0B00700	ENOG4108IQI	permease
HG537_0B00720	ENOG4105D9P	serine threonine protein kinase
HG537_0B00730	ENOG4105E3B	Multicopper oxidase
HG537_0B00730	ENOG4105E3B	Multicopper oxidase
HG537_0B00860	ENOG4105BZ1	(ABC) transporter
HG537_0B00870	ENOG4105DWV	Homoserine O-trans-acetylase
HG537_0B00940	ENOG4108JQ1	Dehydrogenase
HG537_0B01030	ENOG4108IQI	permease
HG537_0B01040	ENOG4108IQI	permease
HG537_0B01110	ENOG4105BZ5	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity)
HG537_0B01290	ENOG4105CDB	Required for chromosome condensation and partitioning (By similarity)
HG537_0B01330	ENOG4105C8N	cysteinyl-tRNA synthetase
HG537_0B01510	ENOG4108I0Z	Aconitate hydratase
HG537_0B01540	ENOG4108RVA	ribokinase
HG537_0B01570	ENOG4105CH6	catalase
HG537_0B01650	ENOG4105CW6	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
HG537_0B01840	ENOG4105C85	amino acid
HG537_0B01870	ENOG4105CB9	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
HG537_0B01930	ENOG4108JIP	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit (By similarity)
HG537_0B01990	ENOG4105C3T	may be the GTPase, regulating ATP sulfurylase activity (By similarity)
HG537_0B02040	ENOG4105CV1	Transketolase (EC 2.2.1.1)
HG537_0B02050	ENOG4105KJF	protein tyrosine phosphatase
HG537_0B02080	ENOG4105C0D	helicase
HG537_0B02130	ENOG4105CCX	Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity)
HG537_0B02190	ENOG4108YX9	iron--sulfur cluster insertion protein erpA
HG537_0B02280	ENOG4105BZ5	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity)
HG537_0B02400	ENOG4105D9P	serine threonine protein kinase
HG537_0B02490	ENOG4107EER	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity)
HG537_0B02580	ENOG4105C7D	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
HG537_0B02630	ENOG4105CJ9	Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity)
HG537_0B02700	ENOG4108Z04	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
HG537_0B02740	ENOG4105BZ5	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity)
HG537_0B02790	ENOG4105CRK	lysyL-tRNA synthetase
HG537_0B02800	ENOG4108UH2	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity)
HG537_0B02910	ENOG4105C0D	helicase
HG537_0B02920	ENOG4108R5J	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity)
HG537_0B02980	ENOG4105E5M	Multidrug resistance protein D
HG537_0B02990	ENOG4105BZ5	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity)
HG537_0B03010	ENOG4105EQY	Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity)
HG537_0B03030	ENOG4105CYJ	ribosomal RNA small subunit methyltransferase B
HG537_0B03090	ENOG4105CIH	Imidazole acetol-phosphate transaminase
HG537_0B03310	ENOG41077A9	carbonic anhydrase
HG537_0B03340	ENOG4105C0C	Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity)
HG537_0B03430	ENOG4108UNN	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity)
HG537_0B03440	ENOG4105D9P	serine threonine protein kinase
HG537_0B03470	ENOG4105D9P	serine threonine protein kinase
HG537_0B03500	ENOG4105BZ5	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity)
HG537_0B03690	ENOG4108UHY	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity)
HG537_0B03740	ENOG4105EW8	cytosine purines, uracil, thiamine, allantoin permease
HG537_0B03790	ENOG4105C8D	Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity)
HG537_0B03860	ENOG4105CV8	reductase
HG537_0B04050	ENOG4107R5B	glutamine synthetase
HG537_0B04150	ENOG4105D9P	serine threonine protein kinase
HG537_0B04260	ENOG4105CDG	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity)
HG537_0B04290	ENOG4107RQD	Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid (By similarity)
HG537_0B04310	ENOG4105C54	Major Facilitator superfamily
HG537_0B04370	ENOG4105CA1	Removes the N-terminal methionine from nascent proteins (By similarity)
HG537_0B04620	ENOG4106YVY	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) (By similarity)
HG537_0B04630	ENOG4105R2D	cytochrome C
HG537_0B04710	ENOG4107EFR	Flavocytochrome c
HG537_0B04830	ENOG4105C54	Major Facilitator superfamily
HG537_0B04880	ENOG4105D27	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
HG537_0B04880	ENOG4105D27	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
HG537_0B04890	ENOG4105HS1	biotin--protein ligase
HG537_0B04910	ENOG4105CJ9	Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity)
HG537_0B05080	ENOG4105D9P	serine threonine protein kinase
HG537_0B05090	ENOG4105C1J	atp-dependent rna helicase
HG537_0B05100	ENOG4105CB1	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate (By similarity)
HG537_0B05150	ENOG4107TRG	DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair (By similarity)
HG537_0B05350	ENOG4105CQB	FAD linked oxidase domain protein
HG537_0B05390	ENOG4105C7B	Threonine dehydratase
HG537_0B05400	ENOG4105C90	Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity)
HG537_0B05500	ENOG4105DSS	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity)
HG537_0B05570	ENOG4105DNJ	May play a role in the repair of endogenous alkylation damage (By similarity)
HG537_0B05590	ENOG4105D3R	alkyl hydroperoxide reductase
HG537_0B05620	ENOG4105C5T	Phosphoribosyl pyrophosphate synthase
HG537_0B05680	ENOG4105CFG	Acts as a chaperone (By similarity)
HG537_0B05690	ENOG4105C07	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity)
HG537_0B05760	ENOG4105CFG	Acts as a chaperone (By similarity)
HG537_0B05780	ENOG4107XGF	functions in a salvage pathway. Uses pyridoxamine (By similarity)
HG537_0B05820	ENOG4105C0D	helicase
HG537_0B05900	ENOG4105K5M	30s ribosomal protein S16
HG537_0B05980	ENOG4105C1J	atp-dependent rna helicase
HG537_0B05990	ENOG4105DI7	Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity)
HG537_0B06040	ENOG4105DXD	2-methylcitrate dehydratase
HG537_0B06090	ENOG4107RAQ	aminopeptidase
HG537_0B06200	ENOG4105NDF	NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity)
HG537_0B06250	ENOG4105CDB	Required for chromosome condensation and partitioning (By similarity)
HG537_0B06280	ENOG4108IQI	permease
HG537_0B06390	ENOG4107QN2	dihydrolipoyl dehydrogenase
HG537_0B06430	ENOG4105CSS	phenylalanyl-tRNA synthetase (alpha subunit)
HG537_0B06530	ENOG4107T0D	ABC, transporter
HG537_0B06580	ENOG4105C65	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity)
HG537_0B06610	ENOG4108RBP	3'-to-5' exoribonuclease specific for small oligoribonucleotides (By similarity)
HG537_0B06620	ENOG4105D9P	serine threonine protein kinase
HG537_0B06730	ENOG4107QNK	)-transporter
HG537_0B06760	ENOG4105CHR	reductase
HG537_0B06780	ENOG4105CEJ	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity)
HG537_0B06790	ENOG4105E3B	Multicopper oxidase
HG537_0B06800	ENOG4105CPQ	Dehydrogenase
HG537_0B07000	ENOG4107SET	aldo keto reductase
HG537_0B07010	ENOG4108X0B	nad(p)h dehydrogenase (quinone)
HG537_0B07070	ENOG4108MXC	l-carnitine dehydratase bile acid-inducible protein F
HG537_0C00150	ENOG4105C54	Major Facilitator superfamily
HG537_0C00160	ENOG4105ENN	converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity)
HG537_0C00210	ENOG4105D8W	glucose-6-phosphate 1-dehydrogenase
HG537_0C00330	ENOG4105BZ5	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity)
HG537_0C00380	ENOG4107QUY	Guanine deaminase
HG537_0C00440	ENOG4105D1H	recombination factor protein RarA
HG537_0C00460	ENOG4105DDT	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity)
HG537_0C00590	ENOG4105CFG	Acts as a chaperone (By similarity)
HG537_0C00640	ENOG4107EXU	Short-chain dehydrogenase reductase Sdr
HG537_0C00660	ENOG4105DR1	Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity)
HG537_0C00860	ENOG4108UIK	This protein binds directly to 23S ribosomal RNA (By similarity)
HG537_0C00920	ENOG4105CKE	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity)
HG537_0C00940	ENOG4105KAP	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity)
HG537_0C01000	ENOG4107QP8	phosphohexose isomerase
HG537_0C01050	ENOG4105C3H	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity)
HG537_0C01230	ENOG4105C26	Dehydrogenase
HG537_0C01330	ENOG4105C1M	carbamoyl-phosphate synthetase glutamine chain
HG537_0C01430	ENOG4108UMW	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity)
HG537_0C01520	ENOG4105CAV	thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity)
HG537_0C01550	ENOG4105C0D	helicase
HG537_0C01560	ENOG4105EMU	Dehydrogenase
HG537_0C01630	ENOG4108TGR	phosphatase
HG537_0C01750	ENOG4105CM0	Catalyzes the synthesis of GMP from XMP (By similarity)
HG537_0C01760	ENOG4105D9P	serine threonine protein kinase
HG537_0C01770	ENOG4105BZ5	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity)
HG537_0C01820	ENOG4105DKX	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity)
HG537_0C01830	ENOG4105E99	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity)
HG537_0C01900	ENOG4105DKZ	GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity)
HG537_0C01920	ENOG4105C0D	helicase
HG537_0C01930	ENOG4108V06	Glutathione peroxidase
HG537_0C01950	ENOG4105CPY	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity)
HG537_0C01980	ENOG4105C54	Major Facilitator superfamily
HG537_0C02000	ENOG4105CKH	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity)
HG537_0C02050	ENOG4105C1J	atp-dependent rna helicase
HG537_0C02130	ENOG4105C1K	alpha-alpha-trehalose-phosphate synthase
HG537_0C02170	ENOG4105EKT	)-iron permease
HG537_0C02250	ENOG4107TQK	Catalyzes the oxidation of the C8 methyl side group on heme O porphyrin ring into a formyl group (By similarity)
HG537_0C02310	ENOG4107EEK	Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity)
HG537_0C02320	ENOG4105DKW	ABC transporter
HG537_0C02370	ENOG4105CYJ	ribosomal RNA small subunit methyltransferase B
HG537_0C02400	ENOG4105C26	Dehydrogenase
HG537_0C02410	ENOG4105C6P	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity)
HG537_0C02480	ENOG4105CYC	Transferase
HG537_0C02510	ENOG4105DDT	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity)
HG537_0C02560	ENOG4105DGU	Histone deacetylase
HG537_0C02630	ENOG4105C17	glyceraldehyde-3-phosphate dehydrogenase
HG537_0C02640	ENOG4105C5I	Dehydrogenase
HG537_0C02650	ENOG4105C28	cystathionine
HG537_0C02690	ENOG4108PBA	serine threonine protein kinase
HG537_0C02810	ENOG4105CZ5	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity)
HG537_0C02920	ENOG4105G6W	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity)
HG537_0C02980	ENOG4105E0I	Catalyzes the formation of N(4)-acetylcytidine (ac(4)C) at the wobble position of tRNA(Met), by using acetyl-CoA as an acetyl donor and ATP (or GTP) (By similarity)
HG537_0C03100	ENOG4105D86	that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity)
HG537_0C03140	ENOG41082NX	50s ribosomal protein l35
HG537_0C03200	ENOG4107QP3	malate synthase g
HG537_0C03310	ENOG4105C1J	atp-dependent rna helicase
HG537_0C03390	ENOG4105CYQ	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity)
HG537_0C03430	ENOG4105CQ2	DNA polymerase
HG537_0C03560	ENOG4105E66	phosphoriboisomerase A
HG537_0C03600	ENOG4108R70	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity)
HG537_0C03630	ENOG4105DFA	alanine racemase domain protein
HG537_0C03670	ENOG4105C5S	asparaginyl-tRNA synthetase
HG537_0C03760	ENOG4105CFG	Acts as a chaperone (By similarity)
HG537_0C03790	ENOG4105C2Z	ATP-dependent CLP protease ATP-binding subunit
HG537_0C03800	ENOG4108Z4V	iron-sulfur cluster assembly
HG537_0C03810	ENOG4105C2C	drug resistance transporter, Bcr CflA
HG537_0C03870	ENOG41067V7	50S ribosomal protein L36
HG537_0C03930	ENOG4105DDT	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity)
HG537_0C03940	ENOG4105VFU	Rna-binding protein
HG537_0C04000	ENOG4105CKK	Glycosyl transferase, family 2
HG537_0C04020	ENOG4105C5H	ABC transporter
HG537_0C04030	ENOG4105CEV	competence damage-inducible protein
HG537_0C04100	ENOG4105CNG	UPF0061 protein
HG537_0C04120	ENOG4105C66	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity)
HG537_0C04200	ENOG4105CKU	formyltetrahydrofolate synthetase
HG537_0C04450	ENOG4105DQ4	alcohol dehydrogenase
HG537_0C04540	ENOG4105CQI	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity)
HG537_0C04570	ENOG4105DWA	May conjugate Arg from its aminoacyl-tRNA to the N- termini of proteins containing an N-terminal aspartate or glutamate
HG537_0C04580	ENOG4108SWN	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA (By similarity)
HG537_0C04690	ENOG4105CG0	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity)
HG537_0C04890	ENOG4108RWI	nicotinamidase
HG537_0C04940	ENOG4105D52	delta-aminolevulinic acid dehydratase
HG537_0C04970	ENOG4108IQI	permease
HG537_0C04990	ENOG4105VFU	Rna-binding protein
HG537_0C05040	ENOG4108UMS	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase (By similarity)
HG537_0C05150	ENOG4108UZ0	Binds to the 23S rRNA (By similarity)
HG537_0C05210	ENOG4105CAQ	asparagine synthetase
HG537_0C05220	ENOG4105CHH	sulfate transporter
HG537_0C05370	ENOG4105C3H	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity)
HG537_0C05480	ENOG4108JIQ	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit (By similarity)
HG537_0C05500	ENOG4105CQ7	ATP-dependent helicase
HG537_0C05540	ENOG4105EKE	dihydroorotase
HG537_0C05560	ENOG4107TH8	cina domain protein
HG537_0C05580	ENOG4105VNB	Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity)
HG537_0C05600	ENOG4105C22	threonyL-tRNA synthetase
HG537_0C05650	ENOG4105DMF	Dehydrogenase
HG537_0C05670	ENOG4105CHR	reductase
HG537_0C05730	ENOG4105CP4	Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity)
HG537_0C05780	ENOG4105C8Y	Acetylornithine aminotransferase
HG537_0C05830	ENOG4107QUV	Domain protein
HG537_0C06170	ENOG4105C28	cystathionine
HG537_0C06330	ENOG4105ET1	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity)
HG537_0C06370	ENOG4105CFH	Aspartokinase
HG537_0C06470	ENOG4105D9P	serine threonine protein kinase
HG537_0C06480	ENOG4105ETX	regulatoR
HG537_0C06510	ENOG4105MK2	5-formyltetrahydrofolate cyclo-ligase
HG537_0C06520	ENOG4105CM2	brancheD-chain amino acid aminotransferase
HG537_0C06540	ENOG4107SET	aldo keto reductase
HG537_0C06550	ENOG4108X0B	nad(p)h dehydrogenase (quinone)
HG537_0D00140	ENOG4105CCY	NADH flavin oxidoreductase, NADH oxidase
HG537_0D00150	ENOG4105D6J	arsenicaL-resistance protein
HG537_0D00160	ENOG4107R5I	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine (By similarity)
HG537_0D00170	ENOG4107QNK	)-transporter
HG537_0D00180	ENOG4107QF7	multi-drug
HG537_0D00210	ENOG4105C9X	ppx gppa phosphatase
HG537_0D00260	ENOG4105KPK	Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation (By similarity)
HG537_0D00270	ENOG4107RF4	Phosphodiesterase
HG537_0D00310	ENOG4105CX6	glutaminyL-tRNA synthetase
HG537_0D00430	ENOG4105CXB	phosphoribosylaminoimidazole synthetase
HG537_0D00550	ENOG4105C3E	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine (By similarity)
HG537_0D00590	ENOG4107QXP	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity)
HG537_0D00660	ENOG4105C5H	ABC transporter
HG537_0D00760	ENOG4105CB3	Required for the thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32) (By similarity)
HG537_0D00870	ENOG4106PT6	cdpdiacylglycerol-serine O-phosphatidyltransferase
HG537_0D00890	ENOG4107SQD	Transcriptional regulator, GntR family
HG537_0D00900	ENOG4107QQN	Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity)
HG537_0D00930	ENOG4105C2X	Arabinose 5-phosphate isomerase
HG537_0D00970	ENOG4107QNK	)-transporter
HG537_0D01040	ENOG4105C80	Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity)
HG537_0D01160	ENOG4105CQ7	ATP-dependent helicase
HG537_0D01170	ENOG4107QNK	)-transporter
HG537_0D01180	ENOG4105C5V	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity)
HG537_0D01280	ENOG4108KBA	Acts as a chaperone (By similarity)
HG537_0D01320	ENOG4108ZGC	gaf domain protein
HG537_0D01420	ENOG4108UGX	Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity)
HG537_0D01510	ENOG4108PBA	serine threonine protein kinase
HG537_0D01630	ENOG4105CHR	reductase
HG537_0D01710	ENOG4105D2N	Aldolase
HG537_0D01760	ENOG4105C1H	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity)
HG537_0D01920	ENOG4105D9P	serine threonine protein kinase
HG537_0D01980	ENOG4105C3G	gtp-binding protein
HG537_0D02110	ENOG4105CIM	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity)
HG537_0D02210	ENOG4108UKJ	Cdp-alcohol phosphatidyltransferase
HG537_0D02240	ENOG4105CA4	amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity)
HG537_0D02270	ENOG4108QVN	serine threonine protein kinase
HG537_0D02480	ENOG4105VFU	Rna-binding protein
HG537_0D02530	ENOG4105D9P	serine threonine protein kinase
HG537_0D02570	ENOG4105C66	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity)
HG537_0D02600	ENOG4107RFD	Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity)
HG537_0D02620	ENOG4105C4R	Atp-dependent dna helicase
HG537_0D02640	ENOG4105D1H	recombination factor protein RarA
HG537_0D02680	ENOG4105D86	that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity)
HG537_0D02930	ENOG41090KN	UPF0303 protein
HG537_0D03130	ENOG4105NDF	NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity)
HG537_0D03190	ENOG4107TK4	histidinol-phosphate phosphatase
HG537_0D03200	ENOG4105CCJ	Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity)
HG537_0D03210	ENOG4105C1J	atp-dependent rna helicase
HG537_0D03240	ENOG4105D9P	serine threonine protein kinase
HG537_0D03270	ENOG4105C5T	Phosphoribosyl pyrophosphate synthase
HG537_0D03290	ENOG4108JU5	Magnesium and cobalt efflux protein
HG537_0D03300	ENOG4105CSF	NADPH-dependent glycerol-3-phosphate dehydrogenase
HG537_0D03310	ENOG4105CDH	Citrulline--aspartate ligase
HG537_0D03320	ENOG4107RPC	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity)
HG537_0D03350	ENOG4105C8V	SAICAR synthetase
HG537_0D03360	ENOG4105D9P	serine threonine protein kinase
HG537_0D03370	ENOG4105D9P	serine threonine protein kinase
HG537_0D03400	ENOG4105DWF	phosphomethylpyrimidine kinase
HG537_0D03440	ENOG4107WDG	serine threonine protein kinase
HG537_0D03510	ENOG4105F0N	pyrophosphate phospho-hydrolase
HG537_0D03520	ENOG4108ZGB	N-(5'-phosphoribosyl)anthranilate isomerase
HG537_0D03600	ENOG4105C26	Dehydrogenase
HG537_0D03640	ENOG4105CR3	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity)
HG537_0D03660	ENOG4105E53	ec 3.2.1.28
HG537_0D03740	ENOG4105KNM	Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity)
HG537_0D03770	ENOG4105C3H	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity)
HG537_0D03780	ENOG4105IDI	abc transporter atp-binding protein
HG537_0D03790	ENOG4105EW8	cytosine purines, uracil, thiamine, allantoin permease
HG537_0D03810	ENOG4105CE7	Amidase, hydantoinase carbamoylase family
HG537_0D03840	ENOG4105C3G	gtp-binding protein
HG537_0D03890	ENOG4108QVN	serine threonine protein kinase
HG537_0D03900	ENOG4105KNE	Phosphatidate cytidylyltransferase
HG537_0D03960	ENOG4108S7T	Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP) (By similarity)
HG537_0D04000	ENOG4105J80	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity)
HG537_0D04020	ENOG4105CEY	Amp-dependent synthetase and ligase
HG537_0D04060	ENOG4105CJ9	Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity)
HG537_0D04070	ENOG4105DBI	uridine monophosphokinase
HG537_0D04100	ENOG4105CGR	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity)
HG537_0D04120	ENOG4105EE6	Alcohol dehydrogenase zinc-binding domain protein
HG537_0D04200	ENOG4105CS1	NAD(P)H quinone oxidoreductase
HG537_0D04260	ENOG4105E99	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity)
HG537_0D04290	ENOG4108UKI	Enoyl-CoA hydratase
HG537_0D04310	ENOG4105D9P	serine threonine protein kinase
HG537_0D04330	ENOG4105CRK	lysyL-tRNA synthetase
HG537_0D04350	ENOG4105F7M	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit (By similarity)
HG537_0D04360	ENOG4108Z10	Involved in the binding of tRNA to the ribosomes (By similarity)
HG537_0D04410	ENOG4105DBS	Key enzyme in heme biosynthesis. Catalyzes the oxidative decarboxylation of propionic acid side chains of rings A and B of coproporphyrinogen III (By similarity)
HG537_0D04450	ENOG4105CP7	Triose-phosphate isomerase
HG537_0D04510	ENOG4105CFZ	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity)
HG537_0D04590	ENOG4105C3P	Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity)
HG537_0D04620	ENOG4105DHM	ATPase which is responsible for recognizing, binding, unfolding and translocation of pupylated proteins into the bacterial 20S proteasome core particle. May be essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C-termini of the proteasomal ATPase may function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis (By similarity)
HG537_0D04780	ENOG4108Z1W	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity)
HG537_0D04800	ENOG4105C6T	cysteine synthase
HG537_0D04870	ENOG4105C8Y	Acetylornithine aminotransferase
HG537_0D04900	ENOG4105CDY	transcriptional regulatory protein
HG537_0D04970	ENOG4108YXY	alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HG537_0D05030	ENOG4105CQ7	ATP-dependent helicase
HG537_0D05060	ENOG4108IQE	Amp-dependent synthetase and ligase
HG537_0D05080	ENOG4105C3H	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity)
HG537_0D05100	ENOG4108RA9	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity)
HG537_0D05110	ENOG4108Z1K	This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity)
HG537_0D05190	ENOG4108R6K	riboflavin synthase, subunit alpha
HG537_0D05230	ENOG4107EER	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity)
HG537_0D05440	ENOG4105C0D	helicase
HG537_0D05450	ENOG410870F	Cyclic nucleotide-binding protein
HG537_0D05480	ENOG4105D9P	serine threonine protein kinase
HG537_0D05570	ENOG4105BZ5	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity)
HG537_0D05620	ENOG4105BZU	Histidine kinase
HG537_0D05730	ENOG4105E21	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity)
HG537_0D05790	ENOG4105KME	endoribonuclease L-psp
HG537_0D05820	ENOG4105C0Q	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity)
HG537_0D05830	ENOG4105EVE	HAD-superfamily hydrolase subfamily IA variant 3
HG537_0D05900	ENOG4105CAS	nag kinase
HG537_0D05950	ENOG4105BZH	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity)
HG537_0D06000	ENOG4105C26	Dehydrogenase
HG537_0D06070	ENOG4107RAQ	aminopeptidase
HG537_0D06120	ENOG4108JQ1	Dehydrogenase
HG537_0D06150	ENOG4107QYT	Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor (By similarity)
HG537_0D06190	ENOG4105C22	threonyL-tRNA synthetase
HG537_0D06240	ENOG4105CQB	FAD linked oxidase domain protein
HG537_0D06250	ENOG4107Z60	histidine triad (HIT) protein
HG537_0D06280	ENOG4105CJS	Phosphopantothenoylcysteine decarboxylase
HG537_0D06500	ENOG4105CC8	Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity)
HG537_0D06510	ENOG410904N	short-chain dehydrogenase reductase
HG537_0D06550	ENOG4105DMF	Dehydrogenase
HG537_0E00180	ENOG4105E78	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity)
HG537_0E00200	ENOG4105CVP	deoxyribo-dipyrimidine photolyase
HG537_0E00290	ENOG4105DGU	Histone deacetylase
HG537_0E00300	ENOG4105C3H	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity)
HG537_0E00380	ENOG4105C8Y	Acetylornithine aminotransferase
HG537_0E00420	ENOG4107XM9	(LipO)protein
HG537_0E00440	ENOG4105C0D	helicase
HG537_0E00480	ENOG4105WHM	Necessary for normal cell division and for the maintenance of normal septation (By similarity)
HG537_0E00500	ENOG4105K77	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity)
HG537_0E00520	ENOG4107QI1	Mate efflux family protein
HG537_0E00570	ENOG4105C75	arginyL-tRNA synthetase
HG537_0E00580	ENOG4105C54	Major Facilitator superfamily
HG537_0E00590	ENOG4105C54	Major Facilitator superfamily
HG537_0E00600	ENOG4105C54	Major Facilitator superfamily
HG537_0E00610	ENOG4107QNK	)-transporter
HG537_0E00760	ENOG4105C3M	thioredoxin reductase
HG537_0E00780	ENOG4107QYG	anthranilate phosphoribosyltransferase
HG537_0E00860	ENOG4105D06	uba thif-type nad fad binding protein
HG537_0E00880	ENOG4105C28	cystathionine
HG537_0E00890	ENOG4105DFM	M18 family aminopeptidase
HG537_0E00910	ENOG4105D27	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
HG537_0E00990	ENOG4105CV8	reductase
HG537_0E01040	ENOG4105CW3	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity)
HG537_0E01090	ENOG4105D3R	alkyl hydroperoxide reductase
HG537_0E01100	ENOG4105C6M	Alpha-keto-beta-hydroxylacyl reductoisomerase
HG537_0E01160	ENOG4105NDF	NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity)
HG537_0E01230	ENOG4105D9P	serine threonine protein kinase
HG537_0E01270	ENOG4108ETH	Formylglycinamide ribotide synthetase
HG537_0E01380	ENOG4105CFG	Acts as a chaperone (By similarity)
HG537_0E01550	ENOG4105M2Z	protein tyrosine serine phosphatase
HG537_0E01580	ENOG4105C8T	Leucyl-tRNA synthetase
HG537_0E01590	ENOG4105C3X	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity)
HG537_0E01680	ENOG4107VK2	coenzyme PQQ biosynthesis protein PqqF
HG537_0E01840	ENOG4105CQR	helicase
HG537_0E01920	ENOG4105CEH	Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity)
HG537_0E02010	ENOG4105C5T	Phosphoribosyl pyrophosphate synthase
HG537_0E02030	ENOG4105CJF	Malonyl coA-acyl carrier protein transacylase
HG537_0E02050	ENOG4105CU5	Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity)
HG537_0E02130	ENOG4107QMP	dna polymerase iii subunits gamma and tau
HG537_0E02150	ENOG4105D0T	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity)
HG537_0E02350	ENOG4105C80	Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity)
HG537_0E02360	ENOG4105HFZ	Membrane
HG537_0E02380	ENOG41080KG	One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity)
HG537_0E02400	ENOG4108PBA	serine threonine protein kinase
HG537_0E02580	ENOG4107QNK	)-transporter
HG537_0E02640	ENOG4105CCW	damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity)
HG537_0E02650	ENOG4105D9P	serine threonine protein kinase
HG537_0E02970	ENOG4105DDZ	Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity)
HG537_0E03050	ENOG4105CFG	Acts as a chaperone (By similarity)
HG537_0E03300	ENOG4105CVK	Glutamate decarboxylase
HG537_0E03320	ENOG4105C26	Dehydrogenase
HG537_0E03330	ENOG4105C40	3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity)
HG537_0E03390	ENOG4105CB9	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
HG537_0E03400	ENOG4108I5C	dEAD DEAH box helicase
HG537_0E03430	ENOG4105D9P	serine threonine protein kinase
HG537_0E03480	ENOG4107EER	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity)
HG537_0E03570	ENOG4105C56	H( )-stimulated, divalent metal cation uptake system (By similarity)
HG537_0E03630	ENOG4107QMU	Mate efflux family protein
HG537_0E03640	ENOG4107QUV	Domain protein
HG537_0E03650	ENOG4105D9P	serine threonine protein kinase
HG537_0E03660	ENOG4105JAB	phenazine biosynthesis protein, phzf family
HG537_0E03670	ENOG4105C5Z	peptidase
HG537_0E03700	ENOG4105D5I	Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity)
HG537_0E03710	ENOG4105C1V	Peptidase, M16
HG537_0E03820	ENOG4107RPC	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity)
HG537_0E03830	ENOG4105DR1	Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity)
HG537_0E03880	ENOG4105C3H	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity)
HG537_0E03930	ENOG4108PPE	Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity)
HG537_0E04000	ENOG4105CFG	Acts as a chaperone (By similarity)
HG537_0E04010	ENOG4108Z6B	deaminase
HG537_0E04050	ENOG4107Z6I	Thiamine biosynthesis protein
HG537_0E04110	ENOG4105BZU	Histidine kinase
HG537_0E04360	ENOG4105C1J	atp-dependent rna helicase
HG537_0E04400	ENOG4107RHB	Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S- adenosylmethionine. Has broad substrate specificity with 6- aminopurine nucleosides as preferred substrates (By similarity)
HG537_0E04520	ENOG4105C31	Tryptophanyl-tRNA synthetase
HG537_0E04640	ENOG4105E05	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity)
HG537_0E04650	ENOG4105C9R	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
HG537_0E04670	ENOG41079KZ	Major Facilitator Superfamily
HG537_0E04680	ENOG4105CKH	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity)
HG537_0E04700	ENOG4105DJ4	phosphatidylserine decarboxylase
HG537_0E04740	ENOG4105EI2	Pseudouridine synthase
HG537_0E04820	ENOG4105CJ9	Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity)
HG537_0E04830	ENOG4105D9P	serine threonine protein kinase
HG537_0E04880	ENOG4105C62	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity)
HG537_0E04900	ENOG4105C17	glyceraldehyde-3-phosphate dehydrogenase
HG537_0E04910	ENOG4107RIQ	Sulfate adenylate transferase
HG537_0E04990	ENOG4105ED0	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity)
HG537_0E05090	ENOG4107UUG	Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity)
HG537_0E05100	ENOG4105CKU	formyltetrahydrofolate synthetase
HG537_0E05110	ENOG4105C29	acyl-CoA thioesterase
HG537_0E05160	ENOG4105C3W	Catalyzes the oxidative ring opening of 3- hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate (By similarity)
HG537_0E05180	ENOG4105TPV	
HG537_0E05190	ENOG4105EAC	phosphoserine phosphatase
HG537_0E05200	ENOG4105C3M	thioredoxin reductase
HG537_0E05240	ENOG4105C9R	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
HG537_0E05360	ENOG4105KBC	Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity)
HG537_0E05370	ENOG4105D9P	serine threonine protein kinase
HG537_0E05380	ENOG4105D9P	serine threonine protein kinase
HG537_0E05390	ENOG4105E09	nadh pyrophosphatase
HG537_0E05460	ENOG4105D9P	serine threonine protein kinase
HG537_0E05470	ENOG4105C1J	atp-dependent rna helicase
HG537_0E05550	ENOG4108UV6	Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity)
HG537_0E05620	ENOG4105F7M	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit (By similarity)
HG537_0E05660	ENOG4105C6P	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity)
HG537_0E05730	ENOG4108I0Z	Aconitate hydratase
HG537_0E05740	ENOG4107EXU	Short-chain dehydrogenase reductase Sdr
HG537_0E05750	ENOG4105BZ1	(ABC) transporter
HG537_0E05760	ENOG4108IQK	o-acetylhomoserine
HG537_0E05800	ENOG4105C3H	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity)
HG537_0E05830	ENOG4105CSP	Major Facilitator Superfamily
HG537_0E05860	ENOG4107QNK	)-transporter
HG537_0E05900	ENOG4108JPX	Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity)
HG537_0E05930	ENOG4108IQI	permease
HG537_0E05940	ENOG4105CV8	reductase
HG537_0E05980	ENOG4105ENN	converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity)
HG537_0E05990	ENOG4105C54	Major Facilitator superfamily
HG537_0F00110	ENOG4105DFH	Transport of potassium into the cell (By similarity)
HG537_0F00120	ENOG4107QNK	)-transporter
HG537_0F00170	ENOG4105C28	cystathionine
HG537_0F00290	ENOG4105D86	that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity)
HG537_0F00300	ENOG4107Q25	Serine Threonine protein kinase
HG537_0F00400	ENOG4105C4G	Synthesis of 3-octaprenyl-4-hydroxybenzoate (By similarity)
HG537_0F00420	ENOG4105K63	Thioredoxin
HG537_0F00460	ENOG4105C1J	atp-dependent rna helicase
HG537_0F00470	ENOG4105K7S	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity)
HG537_0F00490	ENOG4108UKE	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity)
HG537_0F00600	ENOG4105D9P	serine threonine protein kinase
HG537_0F00610	ENOG4108HMN	Caspase domain
HG537_0F00670	ENOG4107XGF	functions in a salvage pathway. Uses pyridoxamine (By similarity)
HG537_0F00790	ENOG4105D98	threonine synthase
HG537_0F00960	ENOG4105DBI	uridine monophosphokinase
HG537_0F00970	ENOG4105CQ7	ATP-dependent helicase
HG537_0F01150	ENOG4108ZIT	Ferredoxin, 2FE-2S
HG537_0F01220	ENOG4105KDC	50s ribosomal protein l28
HG537_0F01250	ENOG4105C9U	ATP-dependent DNA helicase RecQ
HG537_0F01260	ENOG4105CBI	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HG537_0F01280	ENOG4105K87	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal
HG537_0F01360	ENOG4105CJX	Molecular chaperone. Has ATPase activity (By similarity)
HG537_0F01420	ENOG4105DKX	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity)
HG537_0F01460	ENOG41082V8	Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity)
HG537_0F01550	ENOG4105D9P	serine threonine protein kinase
HG537_0F01610	ENOG4105F1R	Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity)
HG537_0F01630	ENOG4105C3H	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity)
HG537_0F01730	ENOG4105BZ5	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity)
HG537_0F01770	ENOG4105CQ2	DNA polymerase
HG537_0F01800	ENOG4105KHC	sulfurtransferase
HG537_0F01870	ENOG4105CBZ	Short-chain dehydrogenase reductase Sdr
HG537_0F01880	ENOG4105C8T	Leucyl-tRNA synthetase
HG537_0F01990	ENOG4106NZV	Responsible for synthesis of pseudouridine from uracil- 13 in transfer RNAs (By similarity)
HG537_0F02010	ENOG4105DPM	folylpolyglutamate synthase Dihydrofolate synthase
HG537_0F02020	ENOG4105D9P	serine threonine protein kinase
HG537_0F02090	ENOG4105C53	Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity)
HG537_0F02160	ENOG4105D9P	serine threonine protein kinase
HG537_0F02170	ENOG4105K90	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
HG537_0F02180	ENOG4105D9P	serine threonine protein kinase
HG537_0F02230	ENOG4107XTC	May be involved in the formation or repair of Fe-S clusters present in iron-sulfur proteins
HG537_0F02290	ENOG4105FT1	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I (By similarity)
HG537_0F02330	ENOG4105C77	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity)
HG537_0F02450	ENOG4107RH7	Nicotinate phosphoribosyltransferase
HG537_0F02560	ENOG4105BZH	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity)
HG537_0F02570	ENOG4105C1J	atp-dependent rna helicase
HG537_0F02590	ENOG4105ECC	imidazole-glycerol-phosphate dehydratase
HG537_0F02610	ENOG4108ZEY	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP) (By similarity)
HG537_0F02650	ENOG4105C0G	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity)
HG537_0F02820	ENOG4105CFG	Acts as a chaperone (By similarity)
HG537_0F02880	ENOG4105C9M	aspartyl-trna synthetase
HG537_0F02890	ENOG4105CCG	Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity)
HG537_0F02950	ENOG4105DA0	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity)
HG537_0F03020	ENOG4105C9R	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
HG537_0F03050	ENOG4105DC8	reductase
HG537_0F03140	ENOG4105C59	p-type ATPase
HG537_0F03170	ENOG4105C31	Tryptophanyl-tRNA synthetase
HG537_0F03380	ENOG4105CV8	reductase
HG537_0F03450	ENOG4105C3H	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity)
HG537_0F03580	ENOG4105D1F	ATP-binding protein
HG537_0F03670	ENOG4105VFU	Rna-binding protein
HG537_0F03690	ENOG4105EIP	mannose-6-phosphate isomerase
HG537_0F03770	ENOG4108JA2	transcriptioN-repair coupling factor
HG537_0F03810	ENOG4105BZ5	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity)
HG537_0F03890	ENOG4105IDI	abc transporter atp-binding protein
HG537_0F04030	ENOG4108CAF	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway (By similarity)
HG537_0F04140	ENOG4105CDB	Required for chromosome condensation and partitioning (By similarity)
HG537_0F04180	ENOG4105C28	cystathionine
HG537_0F04250	ENOG4105CSM	endonuclease III
HG537_0F04440	ENOG4105C2S	Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity)
HG537_0F04570	ENOG4105CIM	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity)
HG537_0F04640	ENOG4105D27	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
HG537_0F04650	ENOG4107QHU	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity)
HG537_0F04660	ENOG4105C9R	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
HG537_0F04690	ENOG4105CQ3	Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity)
HG537_0F04700	ENOG4105CA9	Pyruvate kinase
HG537_0F04710	ENOG4105C85	amino acid
HG537_0F04830	ENOG4105DWH	electron transfer flavoprotein-ubiquinone oxidoreductase
HG537_0F04910	ENOG4105KE9	The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity)
HG537_0F05010	ENOG4108IQF	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity)
HG537_0F05100	ENOG4105C26	Dehydrogenase
HG537_0F05150	ENOG4105D82	Glutamate dehydrogenase
HG537_0G00120	ENOG4105C5H	ABC transporter
HG537_0G00160	ENOG4105DJB	Major Facilitator Superfamily
HG537_0G00210	ENOG4108IEC	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction (By similarity)
HG537_0G00240	ENOG4108ZPD	The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity)
HG537_0G00260	ENOG4105C54	Major Facilitator superfamily
HG537_0G00310	ENOG4105F99	Hydroxymethylglutaryl-CoA synthase
HG537_0G00480	ENOG4108ZBM	Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity)
HG537_0G00500	ENOG4105ECY	inositol monophosphatase
HG537_0G00520	ENOG4108KZ5	Catalyzes the deacetylation of 1D-myo-inositol 2- acetamido-2-deoxy-alpha-D-glucopyranoside (GlcNAc-Ins) in the mycothiol biosynthesis pathway (By similarity)
HG537_0G00560	ENOG4107QSU	Phosphoglucomutase phosphomannomutase alpha beta alpha domain
HG537_0G00690	ENOG4107QP2	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity)
HG537_0G00830	ENOG4105C1K	alpha-alpha-trehalose-phosphate synthase
HG537_0G00950	ENOG4105CVK	Glutamate decarboxylase
HG537_0G01050	ENOG4105PGM	cation diffusion facilitator family transporter
HG537_0G01200	ENOG4105IDI	abc transporter atp-binding protein
HG537_0G01240	ENOG4105D9P	serine threonine protein kinase
HG537_0G01250	ENOG4105CHR	reductase
HG537_0G01360	ENOG4105G6Z	alkaline phosphatase
HG537_0G01460	ENOG4105VFU	Rna-binding protein
HG537_0G01490	ENOG4105C07	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity)
HG537_0G01620	ENOG4105SYT	Methylenetetrahydrofolate reductase
HG537_0G01670	ENOG4105C1J	atp-dependent rna helicase
HG537_0G01680	ENOG4105C3P	Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity)
HG537_0G01740	ENOG4105CW6	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
HG537_0G01790	ENOG4105D6W	Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity)
HG537_0G01800	ENOG4105CQI	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity)
HG537_0G01820	ENOG4107EEK	Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity)
HG537_0G01870	ENOG4107YD0	Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity)
HG537_0G01890	ENOG4107QNK	)-transporter
HG537_0G01940	ENOG4105CC8	Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity)
HG537_0G02080	ENOG4105C6V	Glycerol-3-phosphate dehydrogenase
HG537_0G02110	ENOG4105DJ1	Phosphoenolpyruvate Carboxylase
HG537_0G02160	ENOG4105DDZ	Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity)
HG537_0G02200	ENOG4105BZU	Histidine kinase
HG537_0G02230	ENOG4108IAA	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity)
HG537_0G02340	ENOG4105CHR	reductase
HG537_0G02380	ENOG4105CQ7	ATP-dependent helicase
HG537_0G02430	ENOG4105C0V	Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity)
HG537_0G02500	ENOG4105IES	Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity)
HG537_0G02540	ENOG4105CHF	Glutathione S-transferase
HG537_0G02550	ENOG4105DJ5	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity)
HG537_0G02570	ENOG4105EEE	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity)
HG537_0G02590	ENOG4105D9P	serine threonine protein kinase
HG537_0G02680	ENOG4105CJS	Phosphopantothenoylcysteine decarboxylase
HG537_0G02810	ENOG4105VPI	YqaE family transport protein
HG537_0G02860	ENOG4108RW0	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity)
HG537_0G02960	ENOG4105M2J	Glutaredoxin
HG537_0G03000	ENOG4105CC8	Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity)
HG537_0G03010	ENOG4105D86	that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity)
HG537_0G03090	ENOG4105C0D	helicase
HG537_0G03100	ENOG4108JJB	ABC transporter
HG537_0G03310	ENOG4105DHW	Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins
HG537_0G03330	ENOG4107U9B	transcriptional regulator
HG537_0G03490	ENOG4105CQ7	ATP-dependent helicase
HG537_0G03520	ENOG4108RA9	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity)
HG537_0G03580	ENOG4105CHN	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity)
HG537_0G03600	ENOG4105SYT	Methylenetetrahydrofolate reductase
HG537_0G03620	ENOG4105CEY	Amp-dependent synthetase and ligase
HG537_0G03790	ENOG4105VFU	Rna-binding protein
HG537_0G03830	ENOG4105C0D	helicase
HG537_0G03840	ENOG4105CTM	Glycoside hydrolase family 5
HG537_0G03870	ENOG4105CFB	Gamma-glutamyltranspeptidase (EC 2.3.2.2)
HG537_0G03880	ENOG4105CGV	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity)
HG537_0G03970	ENOG4105C4S	Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity)
HG537_0G03990	ENOG4107QM1	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity)
HG537_0G04070	ENOG4105C8K	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity)
HG537_0G04100	ENOG4105CY0	Metallo-Beta-Lactamase
HG537_0G04160	ENOG4105CFX	Catalyzes the ferrous insertion into protoporphyrin IX (By similarity)
HG537_0G04310	ENOG4105CX6	glutaminyL-tRNA synthetase
HG537_0G04350	ENOG4105CJ9	Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity)
HG537_0G04600	ENOG4105EUB	pirin domain protein
HG537_0G04700	ENOG4107QR7	peptidase S8 and S53, subtilisin, kexin, sedolisin
HG537_0G04710	ENOG4105C9Q	fumarate hydratase class II
HG537_0G04730	ENOG4107QJF	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity)
HG537_0G04790	ENOG4105BZ1	(ABC) transporter
HG537_0G04830	ENOG4105D1X	Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity)
HG537_0G04850	ENOG4108IQI	permease
HG537_0G04870	ENOG4108HKT	sucrose-6-phosphate hydrolase
HG537_0G04890	ENOG4105C0A	alcohol dehydrogenase
HG537_0G04910	ENOG4105CFB	Gamma-glutamyltranspeptidase (EC 2.3.2.2)
HG537_0G04960	ENOG4108W0I	acetyltransferase
HG537_0G05020	ENOG4105CIR	epoxide hydrolase
HG537_0G05030	ENOG4105CCY	NADH flavin oxidoreductase, NADH oxidase
HG537_0H00150	ENOG4108X0B	nad(p)h dehydrogenase (quinone)
HG537_0H00160	ENOG4107SET	aldo keto reductase
HG537_0H00190	ENOG4105CK4	Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity)
HG537_0H00230	ENOG4107RY0	Catalyzes the conversion of dihydroorotate to orotate (By similarity)
HG537_0H00260	ENOG4105CHU	acetyl-coa acetyltransferase
HG537_0H00360	ENOG4105CJ9	Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity)
HG537_0H00400	ENOG4105CKY	Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively (By similarity)
HG537_0H00430	ENOG4105C73	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity)
HG537_0H00500	ENOG4108BDP	Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity)
HG537_0H00550	ENOG4105C1J	atp-dependent rna helicase
HG537_0H00610	ENOG4105NDF	NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity)
HG537_0H00660	ENOG4105KG3	cytidine deaminase
HG537_0H00910	ENOG4108IQF	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity)
HG537_0H01040	ENOG4105CCX	Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity)
HG537_0H01090	ENOG4105KME	endoribonuclease L-psp
HG537_0H01160	ENOG4108IQI	permease
HG537_0H01200	ENOG4107QK3	aspartate-semialdehyde dehydrogenase (EC 1.2.1.11
HG537_0H01280	ENOG4105C7S	Dehydrogenase
HG537_0H01520	ENOG4105BZ1	(ABC) transporter
HG537_0H01530	ENOG4108DT4	serine threonine protein kinase
HG537_0H01720	ENOG4108JNI	Alpha beta hydrolase
HG537_0H01760	ENOG4105D9P	serine threonine protein kinase
HG537_0H01810	ENOG4105BZT	Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity)
HG537_0H01870	ENOG4105C64	Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity)
HG537_0H01910	ENOG4105BZ5	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity)
HG537_0H01960	ENOG4105CDB	Required for chromosome condensation and partitioning (By similarity)
HG537_0H02080	ENOG4108JYK	Dehydrogenase
HG537_0H02220	ENOG4105BZU	Histidine kinase
HG537_0H02440	ENOG4105D3C	The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity)
HG537_0H02480	ENOG4105C35	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity)
HG537_0H02570	ENOG4105CNK	Required, probably indirectly, for the hydroxylation of 2-octaprenylphenol to 2-octaprenyl-6-hydroxy-phenol, the fourth step in ubiquinone biosynthesis (By similarity)
HG537_0H02650	ENOG4105D9P	serine threonine protein kinase
HG537_0H02660	ENOG4105C5H	ABC transporter
HG537_0H02690	ENOG4105CHW	UPF0052 protein
HG537_0H02730	ENOG4105K46	50S ribosomal protein l27
HG537_0H02750	ENOG4105VFU	Rna-binding protein
HG537_0H02810	ENOG4105C0C	Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity)
HG537_0H02850	ENOG4105BZ5	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity)
HG537_0H02860	ENOG4105D0T	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity)
HG537_0H02980	ENOG4105CS1	NAD(P)H quinone oxidoreductase
HG537_0H03050	ENOG4106HK8	GPR1 FUN34 yaaH family protein
HG537_0H03090	ENOG4105IDI	abc transporter atp-binding protein
HG537_0H03100	ENOG4105BZA	Phosphoglycerate kinase
HG537_0H03170	ENOG4105C9C	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity)
HG537_0H03260	ENOG4105CHR	reductase
HG537_0H03320	ENOG4105C5S	asparaginyl-tRNA synthetase
HG537_0H03330	ENOG4105CFN	oxalyl-CoA decarboxylase
HG537_0H03410	ENOG4105C0D	helicase
HG537_0H03430	ENOG4108R5F	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity)
HG537_0H03530	ENOG4105EK0	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity)
HG537_0H03550	ENOG4108IIJ	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
HG537_0H03560	ENOG4105C2W	permease
HG537_0H03820	ENOG4105D9P	serine threonine protein kinase
HG537_0H03840	ENOG4107WDG	serine threonine protein kinase
HG537_0H03860	ENOG4105C1I	TRANSCRIPTIONAl REGULATOR GntR family
HG537_0H03920	ENOG4108QVN	serine threonine protein kinase
HG537_0H03960	ENOG4105C4S	Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity)
HG537_0H04030	ENOG4105FBJ	fumarylacetoacetate (faa) hydrolase
HG537_0H04040	ENOG4108UK2	deaminase
HG537_0H04050	ENOG4105DJ4	phosphatidylserine decarboxylase
HG537_0H04080	ENOG4105VFU	Rna-binding protein
HG537_0H04190	ENOG4108ZMD	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity)
HG537_0H04280	ENOG4108PPE	Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity)
HG537_0H04320	ENOG4105D1H	recombination factor protein RarA
HG537_0H04410	ENOG4105DDZ	Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity)
HG537_0H04430	ENOG4105BZ1	(ABC) transporter
HG537_0H04440	ENOG4105D06	uba thif-type nad fad binding protein
HG537_0H04480	ENOG4105DDQ	anthranilate synthase
HG537_0H04520	ENOG4105D9H	Catalyzes the attachment of glycine to tRNA(Gly) (By similarity)
HG537_0H04570	ENOG4105CQB	FAD linked oxidase domain protein
HG537_0H04580	ENOG4107QK5	Homocysteine s-methyltransferase
HG537_0H04590	ENOG4105C28	cystathionine
HG537_0H04610	ENOG4105CJJ	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity)
HG537_0H04620	ENOG4107QWG	2-Nitropropane dioxygenase