locus-tag	class	description
HG536_0A00120	ENOG4108JPX	Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity)
HG536_0A00140	ENOG4105C54	Major Facilitator superfamily
HG536_0A00150	ENOG4105ENN	converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity)
HG536_0A00240	ENOG4105BZ5	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity)
HG536_0A00430	ENOG4108JJ7	ABC transporter
HG536_0A00440	ENOG4105CBA	glutamine phosphoribosylpyrophosphate amidotransferase
HG536_0A00510	ENOG4107EEK	Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity)
HG536_0A00560	ENOG4105C3P	Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity)
HG536_0A00600	ENOG4105EUJ	GTP cyclohydrolase i
HG536_0A00610	ENOG4105D9P	serine threonine protein kinase
HG536_0A00640	ENOG4105CKH	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity)
HG536_0A00770	ENOG4105C7Q	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity)
HG536_0A00800	ENOG4105CCY	NADH flavin oxidoreductase, NADH oxidase
HG536_0A00840	ENOG4105C70	Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity)
HG536_0A00920	ENOG4105C9R	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
HG536_0A01040	ENOG4105CMV	Succinyl-CoA synthetase subunit beta
HG536_0A01070	ENOG4105CTQ	phosphohexokinase
HG536_0A01160	ENOG4105CJJ	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity)
HG536_0A01330	ENOG4105EEE	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity)
HG536_0A01400	ENOG4105C1J	atp-dependent rna helicase
HG536_0A01570	ENOG4105F91	Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity)
HG536_0A01620	ENOG4105D1F	ATP-binding protein
HG536_0A01760	ENOG4105E33	succinate dehydrogenase
HG536_0A01790	ENOG4105D8C	Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity)
HG536_0A01800	ENOG4107QVN	Key enzyme in the regulation of glycerol uptake and metabolism (By similarity)
HG536_0A01890	ENOG4105FBN	Acid phosphatase
HG536_0A01980	ENOG4105KAP	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity)
HG536_0A02300	ENOG4105C0C	Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity)
HG536_0A02310	ENOG4105CYJ	ribosomal RNA small subunit methyltransferase B
HG536_0A02320	ENOG4105DGU	Histone deacetylase
HG536_0A02330	ENOG4105D9P	serine threonine protein kinase
HG536_0A02490	ENOG4108R5J	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity)
HG536_0A02530	ENOG4105FE8	tRNA (Guanosine-2'-O-)-methyltransferase
HG536_0A02590	ENOG4105C8K	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity)
HG536_0A02600	ENOG4105D9P	serine threonine protein kinase
HG536_0A02670	ENOG4105C26	Dehydrogenase
HG536_0A02690	ENOG4105DC6	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity)
HG536_0A02710	ENOG4105CPM	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity)
HG536_0A02770	ENOG4108MYC	UTP-glucose-1-phosphate uridylyltransferase
HG536_0A02790	ENOG4105BZ5	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity)
HG536_0A02810	ENOG4108UGD	Serine Threonine protein kinase
HG536_0A02840	ENOG4105D0U	Arsenite-activated ATPase (ArsA)
HG536_0A02860	ENOG4108UJY	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity)
HG536_0A03120	ENOG4105C1J	atp-dependent rna helicase
HG536_0A03190	ENOG4108JPX	Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity)
HG536_0A03200	ENOG4107RA9	decarboxylase
HG536_0A03210	ENOG4105D9P	serine threonine protein kinase
HG536_0A03220	ENOG4105C80	Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity)
HG536_0A03230	ENOG4105DKZ	GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity)
HG536_0A03370	ENOG4105DC6	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity)
HG536_0A03410	ENOG4105CQ7	ATP-dependent helicase
HG536_0A03490	ENOG4105DC1	bifunctional purine biosynthesis protein purh
HG536_0A03510	ENOG4105CGF	Aromatic amino acid aminotransferase
HG536_0A03670	ENOG4105DPM	folylpolyglutamate synthase Dihydrofolate synthase
HG536_0A03700	ENOG4105C26	Dehydrogenase
HG536_0A03720	ENOG4105C7K	acetolactate synthase
HG536_0A03760	ENOG4107QIX	Phosphoglucomutase (EC 5.4.2.2
HG536_0A03830	ENOG4105CR3	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity)
HG536_0A03880	ENOG4107QPV	Serine Threonine protein kinase
HG536_0A03890	ENOG4105EFU	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin (By similarity)
HG536_0A03900	ENOG4105C2M	dna polymerase I
HG536_0A03940	ENOG4105C9W	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity)
HG536_0A03960	ENOG4105CD9	Involved in the production of pyridoxal phosphate, probably by incorporating ammonia into the pyridine ring (By similarity)
HG536_0A03970	ENOG4108UHX	Involved in the hydrolysis of glutamine to glutamate and ammonia. Channels an ammonia molecule to PdxS (By similarity)
HG536_0A04030	ENOG4105C3H	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity)
HG536_0A04040	ENOG4105C0R	drug resistance transporter emrb qaca subfamily
HG536_0A04060	ENOG4105CGF	Aromatic amino acid aminotransferase
HG536_0A04080	ENOG4105C46	Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity)
HG536_0A04090	ENOG4105DFM	M18 family aminopeptidase
HG536_0A04100	ENOG4105D9P	serine threonine protein kinase
HG536_0A04400	ENOG4108I67	Catalyzes the synthesis of activated sulfate (By similarity)
HG536_0A04500	ENOG4105KF3	Short-chain dehydrogenase reductase Sdr
HG536_0A04560	ENOG4105CUZ	uba thif-type nad fad binding protein
HG536_0A04580	ENOG4105C6K	Malic enzyme
HG536_0A04680	ENOG4105TMB	Formate nitrite transporter
HG536_0A04720	ENOG4105C5T	Phosphoribosyl pyrophosphate synthase
HG536_0A04825	ENOG4105IQJ	Involved in biosynthesis of the thiamine precursor thiazole (By similarity)
HG536_0A04870	ENOG4107QNK	)-transporter
HG536_0A04900	ENOG4105CUZ	uba thif-type nad fad binding protein
HG536_0A04910	ENOG4105C0C	Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity)
HG536_0A04920	ENOG4105DIN	metallophosphoesterase
HG536_0A05100	ENOG4105DU0	nucleoside hydrolase
HG536_0A05150	ENOG4108IIJ	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
HG536_0A05180	ENOG4105BZ1	(ABC) transporter
HG536_0A05250	ENOG4105KPK	Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation (By similarity)
HG536_0A05260	ENOG4108V3E	phosphoribosylglycinamide formyltransferase
HG536_0A05340	ENOG4105CFD	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
HG536_0A05360	ENOG4105M56	Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity)
HG536_0A05380	ENOG4105D6Z	AFG1 family ATPase
HG536_0A05550	ENOG4105W0E	50S ribosomal protein L33
HG536_0A05660	ENOG4105DDT	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity)
HG536_0A05740	ENOG4105D5S	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity)
HG536_0A05760	ENOG4109003	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity)
HG536_0A05790	ENOG4108V06	Glutathione peroxidase
HG536_0A05810	ENOG4107QNK	)-transporter
HG536_0A05930	ENOG4108UHA	Essential for recycling GMP and indirectly, cGMP (By similarity)
HG536_0A06130	ENOG4105CK4	Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity)
HG536_0A06140	ENOG4105D9P	serine threonine protein kinase
HG536_0A06150	ENOG4105MWK	D-amino acid dehydrogenase, small subunit
HG536_0A06200	ENOG4105CGR	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity)
HG536_0A06290	ENOG4105K5Y	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity)
HG536_0A06320	ENOG4105C1H	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity)
HG536_0A06350	ENOG4105NDF	NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity)
HG536_0A06410	ENOG4105C2Z	ATP-dependent CLP protease ATP-binding subunit
HG536_0A06550	ENOG4105C31	Tryptophanyl-tRNA synthetase
HG536_0A06580	ENOG4105C59	p-type ATPase
HG536_0A06670	ENOG4105DC8	reductase
HG536_0A06700	ENOG4105C9R	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
HG536_0A06770	ENOG4105DA0	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity)
HG536_0A06820	ENOG4107T8T	UPF0173 metal-dependent hydrolase
HG536_0A06830	ENOG4105CCG	Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity)
HG536_0A06840	ENOG4105C9M	aspartyl-trna synthetase
HG536_0A06890	ENOG4105CFG	Acts as a chaperone (By similarity)
HG536_0A07060	ENOG4105C0G	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity)
HG536_0A07100	ENOG4108ZEY	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP) (By similarity)
HG536_0A07120	ENOG4105ECC	imidazole-glycerol-phosphate dehydratase
HG536_0A07140	ENOG4105C1J	atp-dependent rna helicase
HG536_0A07150	ENOG4105BZH	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity)
HG536_0A07260	ENOG4107RH7	Nicotinate phosphoribosyltransferase
HG536_0A07380	ENOG4105C77	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity)
HG536_0A07480	ENOG4107XTC	May be involved in the formation or repair of Fe-S clusters present in iron-sulfur proteins
HG536_0A07530	ENOG4105D9P	serine threonine protein kinase
HG536_0A07540	ENOG4105K90	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
HG536_0A07550	ENOG4105D9P	serine threonine protein kinase
HG536_0A07620	ENOG4105C53	Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity)
HG536_0A07690	ENOG4105D9P	serine threonine protein kinase
HG536_0A07700	ENOG4105DPM	folylpolyglutamate synthase Dihydrofolate synthase
HG536_0A07720	ENOG4106NZV	Responsible for synthesis of pseudouridine from uracil- 13 in transfer RNAs (By similarity)
HG536_0A07840	ENOG4105C8T	Leucyl-tRNA synthetase
HG536_0A07850	ENOG4105CBZ	Short-chain dehydrogenase reductase Sdr
HG536_0A07890	ENOG4105DC6	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity)
HG536_0A07920	ENOG4105KHC	sulfurtransferase
HG536_0A07950	ENOG4105CQ2	DNA polymerase
HG536_0A07990	ENOG4105BZ5	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity)
HG536_0A08090	ENOG4105C3H	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity)
HG536_0A08110	ENOG4105F1R	Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity)
HG536_0A08170	ENOG4105D9P	serine threonine protein kinase
HG536_0A08260	ENOG4107RX2	synthase
HG536_0A08300	ENOG4105DKX	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity)
HG536_0A08360	ENOG4105CJX	Molecular chaperone. Has ATPase activity (By similarity)
HG536_0A08440	ENOG4105K87	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal
HG536_0A08460	ENOG4105CBI	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HG536_0A08470	ENOG4105C9U	ATP-dependent DNA helicase RecQ
HG536_0A08500	ENOG4105KDC	50s ribosomal protein l28
HG536_0A08590	ENOG4108ZIT	Ferredoxin, 2FE-2S
HG536_0A08770	ENOG4105CQ7	ATP-dependent helicase
HG536_0A08780	ENOG4105DBI	uridine monophosphokinase
HG536_0A08950	ENOG4105D98	threonine synthase
HG536_0A09070	ENOG4107XGF	functions in a salvage pathway. Uses pyridoxamine (By similarity)
HG536_0A09100	ENOG4105CKI	cobalamin synthesis protein
HG536_0A09130	ENOG4108HMN	Caspase domain
HG536_0A09140	ENOG4105D9P	serine threonine protein kinase
HG536_0A09260	ENOG4108UKE	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity)
HG536_0A09280	ENOG4105K7S	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity)
HG536_0A09290	ENOG4105C1J	atp-dependent rna helicase
HG536_0A09330	ENOG4105K63	Thioredoxin
HG536_0A09350	ENOG4105C4G	Synthesis of 3-octaprenyl-4-hydroxybenzoate (By similarity)
HG536_0A09450	ENOG4107Q25	Serine Threonine protein kinase
HG536_0A09460	ENOG4105D86	that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity)
HG536_0A09500	ENOG4105E2X	shikimate dehydrogenase
HG536_0A09580	ENOG4105C28	cystathionine
HG536_0A09630	ENOG4107QNK	)-transporter
HG536_0A09660	ENOG4105E2B	Taurine dioxygenase
HG536_0B00120	ENOG4108MXQ	glutathione-regulated potassium-efflux system ancillary protein KefF
HG536_0B00130	ENOG4107SET	aldo keto reductase
HG536_0B00290	ENOG4105F7M	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit (By similarity)
HG536_0B00480	ENOG4105K63	Thioredoxin
HG536_0B00590	ENOG4105E0X	reductase
HG536_0B00640	ENOG4105CEK	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity)
HG536_0B00700	ENOG4108IQI	permease
HG536_0B00720	ENOG4105D9P	serine threonine protein kinase
HG536_0B00730	ENOG4105E3B	Multicopper oxidase
HG536_0B00730	ENOG4105E3B	Multicopper oxidase
HG536_0B00850	ENOG4105BZ1	(ABC) transporter
HG536_0B00860	ENOG4105DWV	Homoserine O-trans-acetylase
HG536_0B00930	ENOG4108JQ1	Dehydrogenase
HG536_0B01020	ENOG4108IQI	permease
HG536_0B01030	ENOG4108IQI	permease
HG536_0B01280	ENOG4105CDB	Required for chromosome condensation and partitioning (By similarity)
HG536_0B01330	ENOG4105C8N	cysteinyl-tRNA synthetase
HG536_0B01520	ENOG4105CQI	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity)
HG536_0B01560	ENOG4108RVA	ribokinase
HG536_0B01590	ENOG4105CH6	catalase
HG536_0B01680	ENOG4105CW6	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
HG536_0B01870	ENOG4105C85	amino acid
HG536_0B01900	ENOG4105CB9	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
HG536_0B01960	ENOG4108JIP	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit (By similarity)
HG536_0B02020	ENOG4105C3T	may be the GTPase, regulating ATP sulfurylase activity (By similarity)
HG536_0B02060	ENOG4105CV1	Transketolase (EC 2.2.1.1)
HG536_0B02070	ENOG4105KJF	protein tyrosine phosphatase
HG536_0B02100	ENOG4105C0D	helicase
HG536_0B02150	ENOG4105CCX	Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity)
HG536_0B02210	ENOG4108YX9	iron--sulfur cluster insertion protein erpA
HG536_0B02230	ENOG4105C17	glyceraldehyde-3-phosphate dehydrogenase
HG536_0B02290	ENOG4105BZ5	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity)
HG536_0B02410	ENOG4105D9P	serine threonine protein kinase
HG536_0B02500	ENOG4107EER	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity)
HG536_0B02590	ENOG4105C7D	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
HG536_0B02640	ENOG4105CJ9	Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity)
HG536_0B02760	ENOG4105BZ5	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity)
HG536_0B02820	ENOG4108UH2	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity)
HG536_0B02930	ENOG4105C0D	helicase
HG536_0B02940	ENOG4108R5J	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity)
HG536_0B03000	ENOG4105E5M	Multidrug resistance protein D
HG536_0B03010	ENOG4105BZ5	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity)
HG536_0B03030	ENOG4105EQY	Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity)
HG536_0B03050	ENOG4105CYJ	ribosomal RNA small subunit methyltransferase B
HG536_0B03110	ENOG4105CIH	Imidazole acetol-phosphate transaminase
HG536_0B03330	ENOG41077A9	carbonic anhydrase
HG536_0B03360	ENOG4105C0C	Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity)
HG536_0B03450	ENOG4108UNN	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity)
HG536_0B03460	ENOG4105D9P	serine threonine protein kinase
HG536_0B03520	ENOG4105BZ5	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity)
HG536_0B03710	ENOG4108UHY	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity)
HG536_0B03760	ENOG4105EW8	cytosine purines, uracil, thiamine, allantoin permease
HG536_0B03830	ENOG4105C8D	Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity)
HG536_0B03900	ENOG4105CV8	reductase
HG536_0B04100	ENOG4107R5B	glutamine synthetase
HG536_0B04180	ENOG4105D9P	serine threonine protein kinase
HG536_0B04290	ENOG4105CDG	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity)
HG536_0B04320	ENOG4107RQD	Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid (By similarity)
HG536_0B04340	ENOG4105C54	Major Facilitator superfamily
HG536_0B04400	ENOG4105CA1	Removes the N-terminal methionine from nascent proteins (By similarity)
HG536_0B04600	ENOG4105CHT	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity)
HG536_0B04650	ENOG4106YVY	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) (By similarity)
HG536_0B04660	ENOG4105R2D	cytochrome C
HG536_0B04740	ENOG4107EFR	Flavocytochrome c
HG536_0B04860	ENOG4105C54	Major Facilitator superfamily
HG536_0B04910	ENOG4105D27	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
HG536_0B04910	ENOG4105D27	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
HG536_0B04920	ENOG4105HS1	biotin--protein ligase
HG536_0B04930	ENOG4105BZQ	cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase
HG536_0B04940	ENOG4105CJ9	Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity)
HG536_0B05120	ENOG4105D9P	serine threonine protein kinase
HG536_0B05130	ENOG4105C1J	atp-dependent rna helicase
HG536_0B05140	ENOG4105CB1	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate (By similarity)
HG536_0B05190	ENOG4107TRG	DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair (By similarity)
HG536_0B05390	ENOG4105CQB	FAD linked oxidase domain protein
HG536_0B05430	ENOG4105C7B	Threonine dehydratase
HG536_0B05440	ENOG4105C90	Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity)
HG536_0B05540	ENOG4105DSS	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity)
HG536_0B05610	ENOG4105DNJ	May play a role in the repair of endogenous alkylation damage (By similarity)
HG536_0B05630	ENOG4105D3R	alkyl hydroperoxide reductase
HG536_0B05660	ENOG4105C5T	Phosphoribosyl pyrophosphate synthase
HG536_0B05720	ENOG4105CFG	Acts as a chaperone (By similarity)
HG536_0B05730	ENOG4105C07	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity)
HG536_0B05810	ENOG4105CFG	Acts as a chaperone (By similarity)
HG536_0B05830	ENOG4107XGF	functions in a salvage pathway. Uses pyridoxamine (By similarity)
HG536_0B05870	ENOG4105C0D	helicase
HG536_0B05950	ENOG4105K5M	30s ribosomal protein S16
HG536_0B06030	ENOG4105C1J	atp-dependent rna helicase
HG536_0B06040	ENOG4105DI7	Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity)
HG536_0B06090	ENOG4105DXD	2-methylcitrate dehydratase
HG536_0B06140	ENOG4107RAQ	aminopeptidase
HG536_0B06180	ENOG4105C10	Electron transfer flavoprotein
HG536_0B06250	ENOG4105NDF	NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity)
HG536_0B06310	ENOG4105CDB	Required for chromosome condensation and partitioning (By similarity)
HG536_0B06340	ENOG4108IQI	permease
HG536_0B06400	ENOG4105BZ5	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity)
HG536_0B06450	ENOG4107QN2	dihydrolipoyl dehydrogenase
HG536_0B06590	ENOG4107T0D	ABC, transporter
HG536_0B06640	ENOG4105C65	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity)
HG536_0B06670	ENOG4108RBP	3'-to-5' exoribonuclease specific for small oligoribonucleotides (By similarity)
HG536_0B06800	ENOG4107QNK	)-transporter
HG536_0B06850	ENOG4105CEJ	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity)
HG536_0B06860	ENOG4105E3B	Multicopper oxidase
HG536_0B06870	ENOG4105CPQ	Dehydrogenase
HG536_0B07080	ENOG4107SET	aldo keto reductase
HG536_0B07100	ENOG4108MXQ	glutathione-regulated potassium-efflux system ancillary protein KefF
HG536_0C00100	ENOG4105CIR	epoxide hydrolase
HG536_0C00120	ENOG4105CCY	NADH flavin oxidoreductase, NADH oxidase
HG536_0C00180	ENOG4107QMW	pyridine nucleotide-disulfide oxidoreductase
HG536_0C00200	ENOG4107RY0	Catalyzes the conversion of dihydroorotate to orotate (By similarity)
HG536_0C00230	ENOG4105CHU	acetyl-coa acetyltransferase
HG536_0C00380	ENOG4105CKY	Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively (By similarity)
HG536_0C00410	ENOG4105C73	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity)
HG536_0C00480	ENOG4108BDP	Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity)
HG536_0C00510	ENOG4108ZQD	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity)
HG536_0C00530	ENOG4105C1J	atp-dependent rna helicase
HG536_0C00590	ENOG4105NDF	NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity)
HG536_0C00640	ENOG4105KG3	cytidine deaminase
HG536_0C00790	ENOG4105C1V	Peptidase, M16
HG536_0C00890	ENOG4108IQF	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity)
HG536_0C01020	ENOG4105CCX	Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity)
HG536_0C01070	ENOG4105KME	endoribonuclease L-psp
HG536_0C01140	ENOG4108IQI	permease
HG536_0C01190	ENOG4107QK3	aspartate-semialdehyde dehydrogenase (EC 1.2.1.11
HG536_0C01400	ENOG4106CJB	Phospholipase Carboxylesterase
HG536_0C01420	ENOG4105EQY	Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity)
HG536_0C01510	ENOG4105BZ1	(ABC) transporter
HG536_0C01520	ENOG4108DT4	serine threonine protein kinase
HG536_0C01710	ENOG4108JNI	Alpha beta hydrolase
HG536_0C01750	ENOG4105D9P	serine threonine protein kinase
HG536_0C01860	ENOG4105C64	Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity)
HG536_0C01900	ENOG4105BZ5	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity)
HG536_0C01950	ENOG4105CDB	Required for chromosome condensation and partitioning (By similarity)
HG536_0C02220	ENOG4105BZU	Histidine kinase
HG536_0C02440	ENOG4105D3C	The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity)
HG536_0C02480	ENOG4105C35	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity)
HG536_0C02570	ENOG4105CNK	Required, probably indirectly, for the hydroxylation of 2-octaprenylphenol to 2-octaprenyl-6-hydroxy-phenol, the fourth step in ubiquinone biosynthesis (By similarity)
HG536_0C02650	ENOG4105D9P	serine threonine protein kinase
HG536_0C02660	ENOG4105C5H	ABC transporter
HG536_0C02690	ENOG4105CHW	UPF0052 protein
HG536_0C02730	ENOG4105K46	50S ribosomal protein l27
HG536_0C02750	ENOG4105VFU	Rna-binding protein
HG536_0C02810	ENOG4105C0C	Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity)
HG536_0C02850	ENOG4105BZ5	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity)
HG536_0C02860	ENOG4105D0T	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity)
HG536_0C03030	ENOG4106HK8	GPR1 FUN34 yaaH family protein
HG536_0C03060	ENOG4105IDI	abc transporter atp-binding protein
HG536_0C03070	ENOG4105BZA	Phosphoglycerate kinase
HG536_0C03100	ENOG4105J80	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity)
HG536_0C03120	ENOG4105CEY	Amp-dependent synthetase and ligase
HG536_0C03170	ENOG4105DBI	uridine monophosphokinase
HG536_0C03200	ENOG4105CHR	reductase
HG536_0C03210	ENOG4105CGR	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity)
HG536_0C03230	ENOG4105EE6	Alcohol dehydrogenase zinc-binding domain protein
HG536_0C03310	ENOG4105CS1	NAD(P)H quinone oxidoreductase
HG536_0C03370	ENOG4105E99	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity)
HG536_0C03400	ENOG4108UKI	Enoyl-CoA hydratase
HG536_0C03440	ENOG4105CRK	lysyL-tRNA synthetase
HG536_0C03460	ENOG4105F7M	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit (By similarity)
HG536_0C03470	ENOG4108Z10	Involved in the binding of tRNA to the ribosomes (By similarity)
HG536_0C03520	ENOG4105DBS	Key enzyme in heme biosynthesis. Catalyzes the oxidative decarboxylation of propionic acid side chains of rings A and B of coproporphyrinogen III (By similarity)
HG536_0C03560	ENOG4105CP7	Triose-phosphate isomerase
HG536_0C03620	ENOG4105CFZ	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity)
HG536_0C03700	ENOG4105C3P	Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity)
HG536_0C03730	ENOG4105DHM	ATPase which is responsible for recognizing, binding, unfolding and translocation of pupylated proteins into the bacterial 20S proteasome core particle. May be essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C-termini of the proteasomal ATPase may function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis (By similarity)
HG536_0C03890	ENOG4108Z1W	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity)
HG536_0C03910	ENOG4105C6T	cysteine synthase
HG536_0C03980	ENOG4105C8Y	Acetylornithine aminotransferase
HG536_0C04080	ENOG4108YXY	alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HG536_0C04140	ENOG4105CQ7	ATP-dependent helicase
HG536_0C04170	ENOG4108IQE	Amp-dependent synthetase and ligase
HG536_0C04190	ENOG4105C3H	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity)
HG536_0C04210	ENOG4108RA9	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity)
HG536_0C04220	ENOG4108Z1K	This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity)
HG536_0C04300	ENOG4108R6K	riboflavin synthase, subunit alpha
HG536_0C04340	ENOG4107EER	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity)
HG536_0C04530	ENOG4105C0D	helicase
HG536_0C04540	ENOG410870F	Cyclic nucleotide-binding protein
HG536_0C04570	ENOG4105D9P	serine threonine protein kinase
HG536_0C04660	ENOG4105BZ5	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity)
HG536_0C04710	ENOG4105BZU	Histidine kinase
HG536_0C04820	ENOG4105E21	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity)
HG536_0C04880	ENOG4105KME	endoribonuclease L-psp
HG536_0C04910	ENOG4105C0Q	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity)
HG536_0C04920	ENOG4105EVE	HAD-superfamily hydrolase subfamily IA variant 3
HG536_0C05000	ENOG4105CAS	nag kinase
HG536_0C05050	ENOG4105BZH	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity)
HG536_0C05100	ENOG4105C26	Dehydrogenase
HG536_0C05170	ENOG4107RAQ	aminopeptidase
HG536_0C05220	ENOG4105CCY	NADH flavin oxidoreductase, NADH oxidase
HG536_0C05230	ENOG4108JQ1	Dehydrogenase
HG536_0C05260	ENOG4107QYT	Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor (By similarity)
HG536_0C05300	ENOG4105C22	threonyL-tRNA synthetase
HG536_0C05350	ENOG4105CQB	FAD linked oxidase domain protein
HG536_0C05360	ENOG4107YU2	histidine triad (hIT) protein
HG536_0C05370	ENOG4105C3H	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity)
HG536_0C05480	ENOG4108JIQ	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit (By similarity)
HG536_0C05500	ENOG4105CQ7	ATP-dependent helicase
HG536_0C05540	ENOG4105EKE	dihydroorotase
HG536_0C05560	ENOG4107TH8	cina domain protein
HG536_0C05580	ENOG4105VNB	Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity)
HG536_0C05650	ENOG4105DMF	Dehydrogenase
HG536_0C05670	ENOG4105CHR	reductase
HG536_0C05730	ENOG4105CP4	Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity)
HG536_0C05780	ENOG4105C8Y	Acetylornithine aminotransferase
HG536_0C05830	ENOG4107QUV	Domain protein
HG536_0C06180	ENOG4105C28	cystathionine
HG536_0C06330	ENOG4105ET1	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity)
HG536_0C06370	ENOG4105CFH	Aspartokinase
HG536_0C06480	ENOG4105ETX	regulatoR
HG536_0C06510	ENOG4105MK2	5-formyltetrahydrofolate cyclo-ligase
HG536_0C06520	ENOG4105CM2	brancheD-chain amino acid aminotransferase
HG536_0D00120	ENOG4108JPX	Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity)
HG536_0D00140	ENOG4105C54	Major Facilitator superfamily
HG536_0D00150	ENOG4105ENN	converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity)
HG536_0D00210	ENOG4105D8W	glucose-6-phosphate 1-dehydrogenase
HG536_0D00220	ENOG4107QHI	-hydrogenase
HG536_0D00330	ENOG4105BZ5	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity)
HG536_0D00380	ENOG4107QUY	Guanine deaminase
HG536_0D00440	ENOG4105D1H	recombination factor protein RarA
HG536_0D00460	ENOG4105DDT	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity)
HG536_0D00590	ENOG4105CFG	Acts as a chaperone (By similarity)
HG536_0D00640	ENOG4107EXU	Short-chain dehydrogenase reductase Sdr
HG536_0D00660	ENOG4105DR1	Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity)
HG536_0D00750	ENOG4108YYA	Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity)
HG536_0D00850	ENOG4108UIK	This protein binds directly to 23S ribosomal RNA (By similarity)
HG536_0D00910	ENOG4105CKE	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity)
HG536_0D00930	ENOG4105KAP	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity)
HG536_0D00990	ENOG4107QP8	phosphohexose isomerase
HG536_0D01040	ENOG4105C3H	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity)
HG536_0D01220	ENOG4105C26	Dehydrogenase
HG536_0D01230	ENOG4107TTQ	Alpha beta hydrolase fold
HG536_0D01320	ENOG4105C1M	carbamoyl-phosphate synthetase glutamine chain
HG536_0D01420	ENOG4108UMW	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity)
HG536_0D01510	ENOG4105CAV	thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity)
HG536_0D01540	ENOG4105C0D	helicase
HG536_0D01550	ENOG4105EMU	Dehydrogenase
HG536_0D01630	ENOG4108TGR	phosphatase
HG536_0D01750	ENOG4105CM0	Catalyzes the synthesis of GMP from XMP (By similarity)
HG536_0D01760	ENOG4105D9P	serine threonine protein kinase
HG536_0D01770	ENOG4105BZ5	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity)
HG536_0D01820	ENOG4105DKX	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity)
HG536_0D01830	ENOG4105E99	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity)
HG536_0D01890	ENOG4105DKZ	GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity)
HG536_0D01920	ENOG4108V06	Glutathione peroxidase
HG536_0D01940	ENOG4105CPY	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity)
HG536_0D01970	ENOG4105C54	Major Facilitator superfamily
HG536_0D01990	ENOG4105CKH	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity)
HG536_0D02040	ENOG4105C1J	atp-dependent rna helicase
HG536_0D02130	ENOG4105C1K	alpha-alpha-trehalose-phosphate synthase
HG536_0D02170	ENOG4105EKT	)-iron permease
HG536_0D02250	ENOG4107TQK	Catalyzes the oxidation of the C8 methyl side group on heme O porphyrin ring into a formyl group (By similarity)
HG536_0D02310	ENOG4107EEK	Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity)
HG536_0D02320	ENOG4105DKW	ABC transporter
HG536_0D02370	ENOG4105CYJ	ribosomal RNA small subunit methyltransferase B
HG536_0D02400	ENOG4105C26	Dehydrogenase
HG536_0D02410	ENOG4105C6P	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity)
HG536_0D02480	ENOG4105CYC	Transferase
HG536_0D02560	ENOG4105DGU	Histone deacetylase
HG536_0D02630	ENOG4105C17	glyceraldehyde-3-phosphate dehydrogenase
HG536_0D02650	ENOG4105C28	cystathionine
HG536_0D02690	ENOG4108PBA	serine threonine protein kinase
HG536_0D02810	ENOG4105CZ5	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity)
HG536_0D02920	ENOG4105G6W	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity)
HG536_0D02950	ENOG4105CPQ	Dehydrogenase
HG536_0D02980	ENOG4105E0I	Catalyzes the formation of N(4)-acetylcytidine (ac(4)C) at the wobble position of tRNA(Met), by using acetyl-CoA as an acetyl donor and ATP (or GTP) (By similarity)
HG536_0D03090	ENOG4105D86	that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity)
HG536_0D03130	ENOG41082NX	50s ribosomal protein l35
HG536_0D03190	ENOG4107QP3	malate synthase g
HG536_0D03270	ENOG4105C1J	atp-dependent rna helicase
HG536_0D03390	ENOG4105CQ2	DNA polymerase
HG536_0D03520	ENOG4105E66	phosphoriboisomerase A
HG536_0D03560	ENOG4108R70	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity)
HG536_0D03590	ENOG4105DFA	alanine racemase domain protein
HG536_0D03630	ENOG4105C5S	asparaginyl-tRNA synthetase
HG536_0D03650	ENOG4108V5V	Serine Threonine protein kinase
HG536_0D03720	ENOG4105CFG	Acts as a chaperone (By similarity)
HG536_0D03750	ENOG4105C2Z	ATP-dependent CLP protease ATP-binding subunit
HG536_0D03760	ENOG4108Z4V	iron-sulfur cluster assembly
HG536_0D03770	ENOG4105C2C	drug resistance transporter, Bcr CflA
HG536_0D03830	ENOG41067V7	50S ribosomal protein L36
HG536_0D03890	ENOG4105DDT	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity)
HG536_0D03900	ENOG4105VFU	Rna-binding protein
HG536_0D03950	ENOG4105CKK	Glycosyl transferase, family 2
HG536_0D03970	ENOG4105C5H	ABC transporter
HG536_0D03980	ENOG4105CEV	competence damage-inducible protein
HG536_0D04050	ENOG4105CNG	UPF0061 protein
HG536_0D04070	ENOG4105C66	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity)
HG536_0D04150	ENOG4105CKU	formyltetrahydrofolate synthetase
HG536_0D04380	ENOG4105DQ4	alcohol dehydrogenase
HG536_0D04470	ENOG4105CQI	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity)
HG536_0D04500	ENOG4105DWA	May conjugate Arg from its aminoacyl-tRNA to the N- termini of proteins containing an N-terminal aspartate or glutamate
HG536_0D04510	ENOG4108SWN	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA (By similarity)
HG536_0D04590	ENOG4105CAE	Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity)
HG536_0D04620	ENOG4105CG0	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity)
HG536_0D04820	ENOG4108RWI	nicotinamidase
HG536_0D04870	ENOG4105D52	delta-aminolevulinic acid dehydratase
HG536_0D04900	ENOG4108IQI	permease
HG536_0D04920	ENOG4105VFU	Rna-binding protein
HG536_0D04970	ENOG4108UMS	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase (By similarity)
HG536_0D05010	ENOG4107QNK	)-transporter
HG536_0D05080	ENOG4108UZ0	Binds to the 23S rRNA (By similarity)
HG536_0D05130	ENOG4107SQD	Transcriptional regulator, GntR family
HG536_0D05140	ENOG4107QQN	Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity)
HG536_0D05170	ENOG4105C2X	Arabinose 5-phosphate isomerase
HG536_0D05210	ENOG4107QNK	)-transporter
HG536_0D05400	ENOG4105CHH	sulfate transporter
HG536_0D05410	ENOG4105CAQ	asparagine synthetase
HG536_0D05430	ENOG4106PT6	cdpdiacylglycerol-serine O-phosphatidyltransferase
HG536_0D05540	ENOG4105D3U	Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity)
HG536_0D05640	ENOG4105C5H	ABC transporter
HG536_0D05750	ENOG4105C3E	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine (By similarity)
HG536_0D05780	ENOG4105BZ5	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity)
HG536_0D05870	ENOG4105CXB	phosphoribosylaminoimidazole synthetase
HG536_0D05990	ENOG4105CX6	glutaminyL-tRNA synthetase
HG536_0D06030	ENOG4107RF4	Phosphodiesterase
HG536_0D06090	ENOG4105C9X	ppx gppa phosphatase
HG536_0D06120	ENOG4107QF7	multi-drug
HG536_0D06130	ENOG4107QNK	)-transporter
HG536_0D06140	ENOG4107R5I	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine (By similarity)
HG536_0D06150	ENOG4105D6J	arsenicaL-resistance protein
HG536_0D06160	ENOG4105CCY	NADH flavin oxidoreductase, NADH oxidase
HG536_0D06170	ENOG4107SET	aldo keto reductase
HG536_0D06180	ENOG4105CHR	reductase
HG536_0D06190	ENOG4105CPC	Aldo Keto reductase
HG536_0D06230	ENOG4108MXQ	glutathione-regulated potassium-efflux system ancillary protein KefF
HG536_0E00110	ENOG4107SET	aldo keto reductase
HG536_0E00120	ENOG4105DMF	Dehydrogenase
HG536_0E00170	ENOG4105E78	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity)
HG536_0E00190	ENOG4105CVP	deoxyribo-dipyrimidine photolyase
HG536_0E00270	ENOG4108UTT	Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity)
HG536_0E00280	ENOG4105DGU	Histone deacetylase
HG536_0E00290	ENOG4105C3H	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity)
HG536_0E00370	ENOG4105C8Y	Acetylornithine aminotransferase
HG536_0E00410	ENOG4107XM9	(LipO)protein
HG536_0E00430	ENOG4105C0D	helicase
HG536_0E00470	ENOG4105WHM	Necessary for normal cell division and for the maintenance of normal septation (By similarity)
HG536_0E00490	ENOG4105K77	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity)
HG536_0E00510	ENOG4107QI1	Mate efflux family protein
HG536_0E00550	ENOG4105C75	arginyL-tRNA synthetase
HG536_0E00560	ENOG4105C54	Major Facilitator superfamily
HG536_0E00570	ENOG4105C54	Major Facilitator superfamily
HG536_0E00580	ENOG4107QNK	)-transporter
HG536_0E00770	ENOG4105C3M	thioredoxin reductase
HG536_0E00790	ENOG4107QYG	anthranilate phosphoribosyltransferase
HG536_0E00890	ENOG4105C28	cystathionine
HG536_0E00900	ENOG4105DFM	M18 family aminopeptidase
HG536_0E00920	ENOG4105D27	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
HG536_0E01000	ENOG4105CV8	reductase
HG536_0E01050	ENOG4105CW3	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity)
HG536_0E01070	ENOG4105D3R	alkyl hydroperoxide reductase
HG536_0E01080	ENOG4105C6M	Alpha-keto-beta-hydroxylacyl reductoisomerase
HG536_0E01140	ENOG4105NDF	NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity)
HG536_0E01210	ENOG4105D9P	serine threonine protein kinase
HG536_0E01250	ENOG4108ETH	Formylglycinamide ribotide synthetase
HG536_0E01360	ENOG4105CFG	Acts as a chaperone (By similarity)
HG536_0E01530	ENOG4105M2Z	protein tyrosine serine phosphatase
HG536_0E01560	ENOG4105C8T	Leucyl-tRNA synthetase
HG536_0E01570	ENOG4105C3X	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity)
HG536_0E01660	ENOG4107VK2	coenzyme PQQ biosynthesis protein PqqF
HG536_0E01820	ENOG4105CQR	helicase
HG536_0E01900	ENOG4105CEH	Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity)
HG536_0E01990	ENOG4105C5T	Phosphoribosyl pyrophosphate synthase
HG536_0E02010	ENOG4105CJF	Malonyl coA-acyl carrier protein transacylase
HG536_0E02030	ENOG4105CU5	Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity)
HG536_0E02110	ENOG4105D1H	recombination factor protein RarA
HG536_0E02130	ENOG4105D0T	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity)
HG536_0E02340	ENOG4105C80	Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity)
HG536_0E02350	ENOG4105HFZ	Membrane
HG536_0E02360	ENOG41080KG	One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity)
HG536_0E02380	ENOG4108PBA	serine threonine protein kinase
HG536_0E02560	ENOG4107QNK	)-transporter
HG536_0E02620	ENOG4105CCW	damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity)
HG536_0E02630	ENOG4105D9P	serine threonine protein kinase
HG536_0E02960	ENOG4105DDZ	Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity)
HG536_0E03040	ENOG4105CFG	Acts as a chaperone (By similarity)
HG536_0E03300	ENOG4105C26	Dehydrogenase
HG536_0E03310	ENOG4105C40	3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity)
HG536_0E03370	ENOG4105CB9	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
HG536_0E03380	ENOG4108I5C	dEAD DEAH box helicase
HG536_0E03410	ENOG4108PBA	serine threonine protein kinase
HG536_0E03460	ENOG4107EER	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity)
HG536_0E03550	ENOG4105C56	H( )-stimulated, divalent metal cation uptake system (By similarity)
HG536_0E03610	ENOG4107QMU	Mate efflux family protein
HG536_0E03620	ENOG4107QUV	Domain protein
HG536_0E03630	ENOG4105D9P	serine threonine protein kinase
HG536_0E03640	ENOG4105JAB	phenazine biosynthesis protein, phzf family
HG536_0E03650	ENOG4105C5Z	peptidase
HG536_0E03680	ENOG4105D5I	Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity)
HG536_0E03690	ENOG4105C1V	Peptidase, M16
HG536_0E03800	ENOG4107RPC	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity)
HG536_0E03810	ENOG4105DR1	Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity)
HG536_0E03860	ENOG4105C3H	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity)
HG536_0E03910	ENOG4108PPE	Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity)
HG536_0E03980	ENOG4105CFG	Acts as a chaperone (By similarity)
HG536_0E03990	ENOG4108Z6B	deaminase
HG536_0E04030	ENOG4107Z6I	Thiamine biosynthesis protein
HG536_0E04090	ENOG4105BZU	Histidine kinase
HG536_0E04310	ENOG4105C1J	atp-dependent rna helicase
HG536_0E04350	ENOG4107RHB	Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S- adenosylmethionine. Has broad substrate specificity with 6- aminopurine nucleosides as preferred substrates (By similarity)
HG536_0E04470	ENOG4105C31	Tryptophanyl-tRNA synthetase
HG536_0E04590	ENOG4105E05	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity)
HG536_0E04600	ENOG4105C9R	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
HG536_0E04620	ENOG41079KZ	Major Facilitator Superfamily
HG536_0E04630	ENOG4105CKH	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity)
HG536_0E04650	ENOG4105DJ4	phosphatidylserine decarboxylase
HG536_0E04690	ENOG4105C34	Pseudouridine synthase
HG536_0E04770	ENOG4105CJ9	Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity)
HG536_0E04830	ENOG4105C62	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity)
HG536_0E04850	ENOG4105C17	glyceraldehyde-3-phosphate dehydrogenase
HG536_0E04860	ENOG4107RIQ	Sulfate adenylate transferase
HG536_0E04940	ENOG4105ED0	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity)
HG536_0E05040	ENOG4107UUG	Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity)
HG536_0E05050	ENOG4105CKU	formyltetrahydrofolate synthetase
HG536_0E05110	ENOG4105C3W	Catalyzes the oxidative ring opening of 3- hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate (By similarity)
HG536_0E05130	ENOG4105TPV	
HG536_0E05140	ENOG4105EAC	phosphoserine phosphatase
HG536_0E05150	ENOG4105C3M	thioredoxin reductase
HG536_0E05190	ENOG4105C9R	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
HG536_0E05310	ENOG4105KBC	Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity)
HG536_0E05320	ENOG4108QVN	serine threonine protein kinase
HG536_0E05330	ENOG4105D9P	serine threonine protein kinase
HG536_0E05410	ENOG4105D9P	serine threonine protein kinase
HG536_0E05420	ENOG4105C1J	atp-dependent rna helicase
HG536_0E05500	ENOG4108UV6	Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity)
HG536_0E05570	ENOG4105F7M	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit (By similarity)
HG536_0E05610	ENOG4105C6P	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity)
HG536_0E05680	ENOG4108I0Z	Aconitate hydratase
HG536_0E05690	ENOG4107EXU	Short-chain dehydrogenase reductase Sdr
HG536_0E05700	ENOG4105BZ1	(ABC) transporter
HG536_0E05710	ENOG4108IQK	o-acetylhomoserine
HG536_0E05750	ENOG4105C3H	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity)
HG536_0E05780	ENOG4105CSP	Major Facilitator Superfamily
HG536_0E05810	ENOG4107QNK	)-transporter
HG536_0E05850	ENOG4108JPX	Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity)
HG536_0E05880	ENOG4108IQI	permease
HG536_0E05900	ENOG4105CV8	reductase
HG536_0E05940	ENOG4105CHR	reductase
HG536_0E05950	ENOG4105D8C	Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity)
HG536_0E05960	ENOG4107SET	aldo keto reductase
HG536_0E05970	ENOG4105CPC	Aldo Keto reductase
HG536_0F00100	ENOG4105CQI	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity)
HG536_0F00120	ENOG4107SET	aldo keto reductase
HG536_0F00170	ENOG4105CKI	cobalamin synthesis protein
HG536_0F00180	ENOG4108UW5	maltose o-acetyltransferase
HG536_0F00190	ENOG4105CHR	reductase
HG536_0F00230	ENOG4105IQJ	Involved in biosynthesis of the thiamine precursor thiazole (By similarity)
HG536_0F00350	ENOG4105CKK	Glycosyl transferase, family 2
HG536_0F00530	ENOG4105ET3	Reduction of activated sulfate into sulfite (By similarity)
HG536_0F00540	ENOG41082AF	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity)
HG536_0F00610	ENOG4105D9P	serine threonine protein kinase
HG536_0F00630	ENOG4105EM7	Selenocysteine-specific translation elongation factor
HG536_0F00670	ENOG4108UHY	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity)
HG536_0F00690	ENOG4105C4J	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity)
HG536_0F00810	ENOG4105VPI	YqaE family transport protein
HG536_0F00900	ENOG4105CZF	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity)
HG536_0F01080	ENOG4105CU6	carbamoyl-phosphate synthetase ammonia chain
HG536_0F01190	ENOG4105DJV	ribulose-phosphate 3-epimerase
HG536_0F01290	ENOG4105CEJ	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity)
HG536_0F01300	ENOG4105C35	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity)
HG536_0F01370	ENOG4105D9P	serine threonine protein kinase
HG536_0F01450	ENOG4105CJ9	Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity)
HG536_0F01480	ENOG4105CPM	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity)
HG536_0F01530	ENOG4105KK9	This protein binds to 23S rRNA in the presence of protein L20 (By similarity)
HG536_0F01540	ENOG4105D9P	serine threonine protein kinase
HG536_0F01560	ENOG4105C4R	Atp-dependent dna helicase
HG536_0F01610	ENOG4105DBV	ornithine carbamoyltransferase
HG536_0F01710	ENOG4105C4S	Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity)
HG536_0F01760	ENOG4105CDB	Required for chromosome condensation and partitioning (By similarity)
HG536_0F01960	ENOG4108ZT0	50S ribosomal protein l17
HG536_0F01980	ENOG4107EXU	Short-chain dehydrogenase reductase Sdr
HG536_0F02040	ENOG4105CHM	Aminotransferase
HG536_0F02070	ENOG4107QPV	Serine Threonine protein kinase
HG536_0F02100	ENOG4108URH	decarboxylase
HG536_0F02210	ENOG4105C65	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity)
HG536_0F02290	ENOG4105DF9	Lipoate-protein, ligase
HG536_0F02340	ENOG4105C90	Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity)
HG536_0F02360	ENOG4105CH7	arginosuccinase
HG536_0F02400	ENOG4105CEP	NADH dehydrogenase
HG536_0F02480	ENOG4107QHU	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity)
HG536_0F02500	ENOG4105C5H	ABC transporter
HG536_0F02510	ENOG4105C40	3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity)
HG536_0F02590	ENOG4107RA9	decarboxylase
HG536_0F02600	ENOG4105CY8	phosphoribosylaminoimidazole carboxylase atpase subunit
HG536_0F02670	ENOG4105JD4	ATPase yjob
HG536_0F02740	ENOG410662T	chitinase
HG536_0F02770	ENOG4105K9H	YciI-like protein
HG536_0F02810	ENOG4105CQP	nitrilase cyanide hydratase and apolipoprotein n-acyltransferase
HG536_0F02920	ENOG4105CV8	reductase
HG536_0F02990	ENOG4105C3H	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity)
HG536_0F03100	ENOG4105D1F	ATP-binding protein
HG536_0F03190	ENOG4105VFU	Rna-binding protein
HG536_0F03210	ENOG4105EIP	mannose-6-phosphate isomerase
HG536_0F03300	ENOG4108JA2	transcriptioN-repair coupling factor
HG536_0F03340	ENOG4105BZ5	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity)
HG536_0F03420	ENOG4105IDI	abc transporter atp-binding protein
HG536_0F03540	ENOG4108CAF	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway (By similarity)
HG536_0F03650	ENOG4105C3X	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity)
HG536_0F03690	ENOG4105C28	cystathionine
HG536_0F03720	ENOG4105K7S	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity)
HG536_0F03960	ENOG4105C2S	Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity)
HG536_0F04120	ENOG4105CIM	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity)
HG536_0F04190	ENOG4105D27	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
HG536_0F04200	ENOG4107QHU	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity)
HG536_0F04210	ENOG4105C9R	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
HG536_0F04240	ENOG4105CQ3	Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity)
HG536_0F04250	ENOG4105CA9	Pyruvate kinase
HG536_0F04260	ENOG4105C85	amino acid
HG536_0F04370	ENOG4105DWH	electron transfer flavoprotein-ubiquinone oxidoreductase
HG536_0F04450	ENOG4105KE9	The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity)
HG536_0F04460	ENOG4105CCY	NADH flavin oxidoreductase, NADH oxidase
HG536_0F04580	ENOG4108IQF	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity)
HG536_0F04670	ENOG4105C26	Dehydrogenase
HG536_0F04710	ENOG4105CPQ	Dehydrogenase
HG536_0F04720	ENOG4105D82	Glutamate dehydrogenase
HG536_0G00110	ENOG4107SET	aldo keto reductase
HG536_0G00120	ENOG4105DMF	Dehydrogenase
HG536_0G00170	ENOG4105CC8	Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity)
HG536_0G00390	ENOG4105CJS	Phosphopantothenoylcysteine decarboxylase
HG536_0G00440	ENOG4105C80	Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity)
HG536_0G00560	ENOG4105CQ7	ATP-dependent helicase
HG536_0G00570	ENOG4107QNK	)-transporter
HG536_0G00580	ENOG4105C5V	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity)
HG536_0G00680	ENOG4105CFG	Acts as a chaperone (By similarity)
HG536_0G00720	ENOG4108ZGC	gaf domain protein
HG536_0G00800	ENOG4108UGX	Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity)
HG536_0G00890	ENOG4108PBA	serine threonine protein kinase
HG536_0G01010	ENOG4105CHR	reductase
HG536_0G01100	ENOG4105D2N	Aldolase
HG536_0G01150	ENOG4105C1H	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity)
HG536_0G01310	ENOG4105D9P	serine threonine protein kinase
HG536_0G01370	ENOG4105C3G	gtp-binding protein
HG536_0G01500	ENOG4105CIM	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity)
HG536_0G01600	ENOG4108UKJ	Cdp-alcohol phosphatidyltransferase
HG536_0G01630	ENOG4105CA4	amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity)
HG536_0G01660	ENOG4108QVN	serine threonine protein kinase
HG536_0G01880	ENOG4105VFU	Rna-binding protein
HG536_0G01930	ENOG4105D9P	serine threonine protein kinase
HG536_0G01970	ENOG4105C66	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity)
HG536_0G02000	ENOG4108HWB	Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity)
HG536_0G02020	ENOG4105C4R	Atp-dependent dna helicase
HG536_0G02040	ENOG4105D1H	recombination factor protein RarA
HG536_0G02080	ENOG4105D86	that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity)
HG536_0G02090	ENOG4105CV8	reductase
HG536_0G02150	ENOG4105D1W	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity)
HG536_0G02340	ENOG41090KN	UPF0303 protein
HG536_0G02540	ENOG4105NDF	NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity)
HG536_0G02600	ENOG4107TK4	histidinol-phosphate phosphatase
HG536_0G02610	ENOG4105CCJ	Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity)
HG536_0G02620	ENOG4105C1J	atp-dependent rna helicase
HG536_0G02650	ENOG4105D9P	serine threonine protein kinase
HG536_0G02680	ENOG4105C5T	Phosphoribosyl pyrophosphate synthase
HG536_0G02710	ENOG4105CSF	NADPH-dependent glycerol-3-phosphate dehydrogenase
HG536_0G02720	ENOG4105CDH	Citrulline--aspartate ligase
HG536_0G02730	ENOG4107RPC	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity)
HG536_0G02750	ENOG4105DWF	phosphomethylpyrimidine kinase
HG536_0G02780	ENOG4105D9P	serine threonine protein kinase
HG536_0G02790	ENOG4105D9P	serine threonine protein kinase
HG536_0G02800	ENOG4105C8V	SAICAR synthetase
HG536_0G02940	ENOG4105F0N	pyrophosphate phospho-hydrolase
HG536_0G02950	ENOG4108ZGB	N-(5'-phosphoribosyl)anthranilate isomerase
HG536_0G03020	ENOG4105C26	Dehydrogenase
HG536_0G03060	ENOG4105CR3	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity)
HG536_0G03080	ENOG4105E53	ec 3.2.1.28
HG536_0G03160	ENOG4105KNM	Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity)
HG536_0G03190	ENOG4105C3H	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity)
HG536_0G03200	ENOG4105IDI	abc transporter atp-binding protein
HG536_0G03210	ENOG4105EW8	cytosine purines, uracil, thiamine, allantoin permease
HG536_0G03230	ENOG4105CE7	Amidase, hydantoinase carbamoylase family
HG536_0G03260	ENOG4105C3G	gtp-binding protein
HG536_0G03290	ENOG4105D9P	serine threonine protein kinase
HG536_0G03300	ENOG4105KNE	Phosphatidate cytidylyltransferase
HG536_0G03360	ENOG4108S7T	Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP) (By similarity)
HG536_0G03460	ENOG4105C9C	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity)
HG536_0G03550	ENOG4105CHR	reductase
HG536_0G03620	ENOG4105CFN	oxalyl-CoA decarboxylase
HG536_0G03670	ENOG4107XH4	PPIases accelerate the folding of proteins (By similarity)
HG536_0G03700	ENOG4105C0D	helicase
HG536_0G03720	ENOG4108R5F	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity)
HG536_0G03820	ENOG4105EK0	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity)
HG536_0G03840	ENOG4108IIJ	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
HG536_0G03850	ENOG4105C2W	permease
HG536_0G03950	ENOG4105C1J	atp-dependent rna helicase
HG536_0G04110	ENOG4105D9P	serine threonine protein kinase
HG536_0G04130	ENOG4107WDG	serine threonine protein kinase
HG536_0G04140	ENOG4105C1I	TRANSCRIPTIONAl REGULATOR GntR family
HG536_0G04200	ENOG4108QVN	serine threonine protein kinase
HG536_0G04240	ENOG4105C4S	Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity)
HG536_0G04310	ENOG4105FBJ	fumarylacetoacetate (faa) hydrolase
HG536_0G04320	ENOG4108UK2	deaminase
HG536_0G04330	ENOG4105DJ4	phosphatidylserine decarboxylase
HG536_0G04360	ENOG4105VFU	Rna-binding protein
HG536_0G04470	ENOG4108ZMD	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity)
HG536_0G04560	ENOG4108PPE	Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity)
HG536_0G04610	ENOG4105D1H	recombination factor protein RarA
HG536_0G04640	ENOG4108V82	Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity)
HG536_0G04700	ENOG4105DDZ	Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity)
HG536_0G04720	ENOG4105BZ1	(ABC) transporter
HG536_0G04730	ENOG4105D06	uba thif-type nad fad binding protein
HG536_0G04770	ENOG4105DDQ	anthranilate synthase
HG536_0G04810	ENOG4105D9H	Catalyzes the attachment of glycine to tRNA(Gly) (By similarity)
HG536_0G04870	ENOG4105CQB	FAD linked oxidase domain protein
HG536_0G04880	ENOG4107QK5	Homocysteine s-methyltransferase
HG536_0G04890	ENOG4105C28	cystathionine
HG536_0G04910	ENOG4105CJJ	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity)
HG536_0G04920	ENOG4107QWG	2-Nitropropane dioxygenase
HG536_0G04930	ENOG4107SET	aldo keto reductase
HG536_0G04980	ENOG4105CIR	epoxide hydrolase
HG536_0H00130	ENOG4105C5H	ABC transporter
HG536_0H00140	ENOG4105D8C	Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity)
HG536_0H00170	ENOG4105DJB	Major Facilitator Superfamily
HG536_0H00220	ENOG4108IEC	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction (By similarity)
HG536_0H00250	ENOG4108ZPD	The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity)
HG536_0H00270	ENOG4105C54	Major Facilitator superfamily
HG536_0H00310	ENOG4107SC0	ferredoxin--NADP reductase
HG536_0H00330	ENOG4105F99	Hydroxymethylglutaryl-CoA synthase
HG536_0H00500	ENOG4108ZBM	Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity)
HG536_0H00520	ENOG4105ECY	inositol monophosphatase
HG536_0H00540	ENOG4108KZ5	Catalyzes the deacetylation of 1D-myo-inositol 2- acetamido-2-deoxy-alpha-D-glucopyranoside (GlcNAc-Ins) in the mycothiol biosynthesis pathway (By similarity)
HG536_0H00580	ENOG4107QSU	Phosphoglucomutase phosphomannomutase alpha beta alpha domain
HG536_0H00720	ENOG4107QP2	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity)
HG536_0H00860	ENOG4105C1K	alpha-alpha-trehalose-phosphate synthase
HG536_0H00980	ENOG4105CVK	Glutamate decarboxylase
HG536_0H01090	ENOG4105PGM	cation diffusion facilitator family transporter
HG536_0H01240	ENOG4105IDI	abc transporter atp-binding protein
HG536_0H01280	ENOG4105D9P	serine threonine protein kinase
HG536_0H01290	ENOG4105UBK	short-chain dehydrogenase reductase
HG536_0H01400	ENOG4105G6Z	alkaline phosphatase
HG536_0H01500	ENOG4105VFU	Rna-binding protein
HG536_0H01530	ENOG4105C07	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity)
HG536_0H01620	ENOG4108Z67	carbohydrate kinase, thermoresistant glucokinase family
HG536_0H01660	ENOG4105SYT	Methylenetetrahydrofolate reductase
HG536_0H01710	ENOG4105C1J	atp-dependent rna helicase
HG536_0H01720	ENOG4105C3P	Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity)
HG536_0H01780	ENOG4105CW6	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
HG536_0H01830	ENOG4105D6W	Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity)
HG536_0H01840	ENOG4105CQI	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity)
HG536_0H01860	ENOG4107EEK	Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity)
HG536_0H01910	ENOG4107YD0	Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity)
HG536_0H01930	ENOG4107QNK	)-transporter
HG536_0H01980	ENOG4105CC8	Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity)
HG536_0H02120	ENOG4105C6V	Glycerol-3-phosphate dehydrogenase
HG536_0H02150	ENOG4105DJ1	Phosphoenolpyruvate Carboxylase
HG536_0H02240	ENOG4105BZU	Histidine kinase
HG536_0H02270	ENOG4107QQT	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity)
HG536_0H02380	ENOG4105CHR	reductase
HG536_0H02420	ENOG4105CQ7	ATP-dependent helicase
HG536_0H02470	ENOG4105C0V	Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity)
HG536_0H02540	ENOG4105IES	Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity)
HG536_0H02580	ENOG4105CHF	Glutathione S-transferase
HG536_0H02590	ENOG4105DJ5	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity)
HG536_0H02610	ENOG4105EEE	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity)
HG536_0H02630	ENOG4105D9P	serine threonine protein kinase
HG536_0H02700	ENOG4105CJS	Phosphopantothenoylcysteine decarboxylase
HG536_0H02740	ENOG4105CB8	Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity)
HG536_0H02830	ENOG4105VPI	YqaE family transport protein
HG536_0H02880	ENOG4108RW0	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity)
HG536_0H02960	ENOG410626R	Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity)
HG536_0H02970	ENOG4105M2J	Glutaredoxin
HG536_0H03020	ENOG4105D86	that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity)
HG536_0H03090	ENOG4105C0D	helicase
HG536_0H03100	ENOG4108JJB	ABC transporter
HG536_0H03300	ENOG4105DHW	Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins
HG536_0H03320	ENOG4107U9B	transcriptional regulator
HG536_0H03490	ENOG4105CQ7	ATP-dependent helicase
HG536_0H03520	ENOG4108RA9	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity)
HG536_0H03580	ENOG4105CHN	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity)
HG536_0H03600	ENOG4105SYT	Methylenetetrahydrofolate reductase
HG536_0H03620	ENOG4105CEY	Amp-dependent synthetase and ligase
HG536_0H03770	ENOG4105CB8	Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity)
HG536_0H03780	ENOG4105VFU	Rna-binding protein
HG536_0H03820	ENOG4105C0D	helicase
HG536_0H03830	ENOG4105CTM	Glycoside hydrolase family 5
HG536_0H03860	ENOG4105CFB	Gamma-glutamyltranspeptidase (EC 2.3.2.2)
HG536_0H03870	ENOG4105CGV	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity)
HG536_0H03950	ENOG4105C4S	Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity)
HG536_0H03970	ENOG4107QM1	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity)
HG536_0H04050	ENOG4105C8K	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity)
HG536_0H04080	ENOG4105CY0	Metallo-Beta-Lactamase
HG536_0H04090	ENOG4105C1J	atp-dependent rna helicase
HG536_0H04140	ENOG4105CFX	Catalyzes the ferrous insertion into protoporphyrin IX (By similarity)
HG536_0H04290	ENOG4105CX6	glutaminyL-tRNA synthetase
HG536_0H04330	ENOG4105CJ9	Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity)
HG536_0H04480	ENOG4105D9P	serine threonine protein kinase
HG536_0H04560	ENOG4105EUB	pirin domain protein
HG536_0H04660	ENOG4107QR7	peptidase S8 and S53, subtilisin, kexin, sedolisin
HG536_0H04670	ENOG4105C9Q	fumarate hydratase class II
HG536_0H04690	ENOG4107QJF	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity)
HG536_0H04750	ENOG4105BZ1	(ABC) transporter
HG536_0H04790	ENOG4105D1X	Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity)
HG536_0H04820	ENOG4108IQI	permease
HG536_0H04850	ENOG4108HKT	sucrose-6-phosphate hydrolase
HG536_0H04870	ENOG4105C0A	alcohol dehydrogenase
HG536_0H04890	ENOG4105CFB	Gamma-glutamyltranspeptidase (EC 2.3.2.2)
HG536_0H04930	ENOG4105CCY	NADH flavin oxidoreductase, NADH oxidase