locus-tag	class	description
HG537_0A00150	COG2814	Major facilitator Superfamily
HG537_0A00160	COG2017	converts alpha-aldose to the beta-anomer
HG537_0A00400	COG5265	(ABC) transporter
HG537_0A00480	COG0156	8-amino-7-oxononanoate synthase activity
HG537_0A00530	COG0154	amidase activity
HG537_0A00570	COG0302	gtp cyclohydrolase
HG537_0A00580	COG0515	serine threonine protein kinase
HG537_0A00610	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HG537_0A00610	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HG537_0A00740	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
HG537_0A00770	COG1902	pentaerythritol trinitrate reductase activity
HG537_0A00810	COG0148	phosphopyruvate hydratase activity
HG537_0A00890	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
HG537_0A01010	COG0045	succinate-CoA ligase (ADP-forming) activity
HG537_0A01040	COG0205	6-phosphofructokinase activity
HG537_0A01120	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HG537_0A01120	COG1017	nitric oxide dioxygenase activity
HG537_0A01290	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
HG537_0A01360	COG0513	Belongs to the DEAD box helicase family
HG537_0A01530	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
HG537_0A01580	COG0489	protein tyrosine kinase activity
HG537_0A01750	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
HG537_0A01760	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
HG537_0A01940	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
HG537_0A02260	COG0473	3-isopropylmalate dehydrogenase activity
HG537_0A02270	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
HG537_0A02270	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HG537_0A02290	COG0515	serine threonine protein kinase
HG537_0A02290	COG2815	serine threonine protein kinase
HG537_0A02330	COG1965	Belongs to the frataxin family
HG537_0A02410	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HG537_0A02410	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HG537_0A02420	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
HG537_0A02450	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
HG537_0A02470	COG1028	Short-chain dehydrogenase reductase Sdr
HG537_0A02490	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HG537_0A02500	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
HG537_0A02550	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
HG537_0A02630	COG1012	belongs to the aldehyde dehydrogenase family
HG537_0A02650	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
HG537_0A02670	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
HG537_0A02720	COG4284	Utp--glucose-1-phosphate uridylyltransferase
HG537_0A02740	COG0484	heat shock protein binding
HG537_0A02760	COG0515	serine threonine protein kinase
HG537_0A02800	COG0003	Pfam Anion-transporting ATPase
HG537_0A03020	COG0412	Dienelactone hydrolase
HG537_0A03070	COG0513	Belongs to the DEAD box helicase family
HG537_0A03130	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HG537_0A03140	COG3961	Belongs to the TPP enzyme family
HG537_0A03160	COG0039	L-malate dehydrogenase activity
HG537_0A03310	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
HG537_0A03350	COG1643	Atp-dependent helicase
HG537_0A03370	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HG537_0A03620	COG0285	dihydrofolate synthase activity
HG537_0A03670	COG0028	Belongs to the TPP enzyme family
HG537_0A03710	COG0033	Phosphoglucomutase
HG537_0A03720	COG0515	serine threonine protein kinase
HG537_0A03720	COG2815	serine threonine protein kinase
HG537_0A03780	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
HG537_0A03840	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
HG537_0A03850	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HG537_0A03850	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HG537_0A03890	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
HG537_0A03910	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
HG537_0A03920	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
HG537_0A03980	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HG537_0A03990	COG0477	Major facilitator Superfamily
HG537_0A04000	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
HG537_0A04010	COG1448	Aminotransferase
HG537_0A04030	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HG537_0A04040	COG1362	aminopeptidase activity
HG537_0A04050	COG2815	serine threonine protein kinase
HG537_0A04050	COG0515	serine threonine protein kinase
HG537_0A04120	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
HG537_0A04360	COG0529	Catalyzes the synthesis of activated sulfate
HG537_0A04480	COG1028	Short-chain dehydrogenase reductase Sdr
HG537_0A04540	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
HG537_0A04560	COG0281	malic enzyme
HG537_0A04670	COG2116	formate transmembrane transporter activity
HG537_0A04710	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HG537_0A04820	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HG537_0A04840	COG2814	Major facilitator Superfamily
HG537_0A04870	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
HG537_0A04880	COG0473	3-isopropylmalate dehydrogenase activity
HG537_0A04930	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
HG537_0A05010	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HG537_0A05120	COG0085	RNA polymerase activity
HG537_0A05150	COG1716	ATPase activity
HG537_0A05150	COG0842	Transport permease protein
HG537_0A05150	COG1131	(ABC) transporter
HG537_0A05220	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
HG537_0A05230	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
HG537_0A05310	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
HG537_0A05330	COG1394	ATPase activity, coupled to movement of substances
HG537_0A05350	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
HG537_0A05510	COG0267	Belongs to the bacterial ribosomal protein bL33 family
HG537_0A05620	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
HG537_0A05710	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HG537_0A05740	COG0386	Belongs to the glutathione peroxidase family
HG537_0A05760	COG2814	Major facilitator Superfamily
HG537_0A05850	COG0450	alkyl hydroperoxide reductase
HG537_0A05880	COG0194	GDP metabolic process
HG537_0A05890	COG0025	NhaP-type Na H and K H
HG537_0A06080	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
HG537_0A06090	COG0515	serine threonine protein kinase
HG537_0A06100	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HG537_0A06150	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
HG537_0A06240	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
HG537_0A06360	COG0542	response to heat
HG537_0A06440	COG2350	Protein conserved in bacteria
HG537_0A06540	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HG537_0A06610	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
HG537_0A06620	COG3961	Belongs to the TPP enzyme family
HG537_0A06680	COG0557	exoribonuclease II activity
HG537_0A06690	COG0488	(ABC) transporter
HG537_0A06710	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
HG537_0A06790	COG1252	NADH dehydrogenase
HG537_0A06830	COG0165	Argininosuccinate lyase
HG537_0A06840	COG0017	Asparaginyl-tRNA synthetase
HG537_0A06850	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
HG537_0A06900	COG0095	Lipoate-protein ligase
HG537_0A06980	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
HG537_0A06990	COG0481	GTPase activity
HG537_0A07120	COG0515	serine threonine protein kinase
HG537_0A07150	COG0436	Aminotransferase
HG537_0A07230	COG0203	ribosomal protein L17
HG537_0A07410	COG0484	heat shock protein binding
HG537_0A07600	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
HG537_0A07660	COG0475	glutathione-regulated potassium exporter activity
HG537_0A07680	COG0261	This protein binds to 23S rRNA in the presence of protein L20
HG537_0A07680	COG3743	rRNA binding
HG537_0A07730	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
HG537_0A07760	COG0459	protein refolding
HG537_0A07840	COG2815	serine threonine protein kinase
HG537_0A07840	COG0515	serine threonine protein kinase
HG537_0A07890	COG0513	Belongs to the DEAD box helicase family
HG537_0A07910	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
HG537_0A07920	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HG537_0A08020	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HG537_0A08080	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HG537_0A08120	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HG537_0A08130	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
HG537_0A08220	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HG537_0A08290	COG2815	serine threonine protein kinase
HG537_0A08290	COG0515	serine threonine protein kinase
HG537_0A08310	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
HG537_0A08450	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HG537_0A08520	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HG537_0A08530	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
HG537_0A08550	COG0049	tRNA binding
HG537_0A08680	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
HG537_0A08690	COG0175	sulfate reduction
HG537_0A08870	COG0463	Glycosyl transferase, family 2
HG537_0A08990	COG1635	Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur
HG537_0A09020	COG1028	Short-chain dehydrogenase reductase Sdr
HG537_0A09030	COG0110	maltose O-acetyltransferase activity
HG537_0A09040	COG0523	cobalamin synthesis protein
HG537_0A09070	COG3961	Belongs to the TPP enzyme family
HG537_0A09080	COG0039	L-malate dehydrogenase activity
HG537_0A09090	COG0667	Aldo Keto reductase
HG537_0B00150	COG2175	clavaminate synthase activity
HG537_0B00180	COG1902	pentaerythritol trinitrate reductase activity
HG537_0B00310	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
HG537_0B00460	COG0545	Peptidyl-prolyl cis-trans isomerase
HG537_0B00490	COG3118	belongs to the thioredoxin family
HG537_0B00590	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HG537_0B00700	COG0833	amino acid
HG537_0B00720	COG0515	serine threonine protein kinase
HG537_0B00720	COG2815	serine threonine protein kinase
HG537_0B00730	COG2132	Multicopper oxidase
HG537_0B00730	COG2132	Multicopper oxidase
HG537_0B00860	COG1132	(ABC) transporter
HG537_0B00870	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HG537_0B00880	COG1819	glycosyl
HG537_0B00940	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HG537_0B01030	COG0833	amino acid
HG537_0B01040	COG0833	amino acid
HG537_0B01110	COG0484	heat shock protein binding
HG537_0B01200	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
HG537_0B01220	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HG537_0B01230	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
HG537_0B01290	COG1196	nuclear chromosome segregation
HG537_0B01330	COG0215	cysteine-tRNA ligase activity
HG537_0B01540	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HG537_0B01570	COG0753	catalase activity
HG537_0B01840	COG1113	amino acid transport
HG537_0B01870	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
HG537_0B01930	COG1156	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit
HG537_0B01990	COG2895	sulfate adenylyltransferase (ATP) activity
HG537_0B02040	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
HG537_0B02050	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HG537_0B02080	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HG537_0B02190	COG0316	Belongs to the HesB IscA family
HG537_0B02280	COG0484	heat shock protein binding
HG537_0B02490	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
HG537_0B02490	COG2124	cytochrome p450
HG537_0B02580	COG0187	DNA topoisomerase II activity
HG537_0B02630	COG0459	protein refolding
HG537_0B02700	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
HG537_0B02740	COG0484	heat shock protein binding
HG537_0B02790	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
HG537_0B02800	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
HG537_0B02810	COG0508	dehydrogenase complex catalyzes the overall conversion of
HG537_0B02910	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HG537_0B02920	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
HG537_0B02980	COG2814	Major facilitator Superfamily
HG537_0B02990	COG0484	heat shock protein binding
HG537_0B03010	COG2890	protein-(glutamine-N5) methyltransferase activity
HG537_0B03030	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
HG537_0B03030	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
HG537_0B03090	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HG537_0B03310	COG0288	reversible hydration of carbon dioxide
HG537_0B03340	COG0473	3-isopropylmalate dehydrogenase activity
HG537_0B03400	COG0142	geranyltranstransferase activity
HG537_0B03430	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
HG537_0B03440	COG0515	serine threonine protein kinase
HG537_0B03470	COG2815	serine threonine protein kinase
HG537_0B03470	COG0515	serine threonine protein kinase
HG537_0B03500	COG0484	heat shock protein binding
HG537_0B03740	COG1953	Uracil, thiamine, allantoin
HG537_0B03790	COG0504	CTP synthase activity
HG537_0B03860	COG0656	L-ascorbic acid biosynthetic process
HG537_0B04150	COG2815	serine threonine protein kinase
HG537_0B04150	COG0515	serine threonine protein kinase
HG537_0B04260	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
HG537_0B04290	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HG537_0B04310	COG2814	Major facilitator Superfamily
HG537_0B04370	COG0024	Methionine aminopeptidase
HG537_0B04620	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
HG537_0B04630	COG3474	cytochrome
HG537_0B04650	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
HG537_0B04710	COG1053	succinate dehydrogenase
HG537_0B04830	COG2814	Major facilitator Superfamily
HG537_0B04870	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HG537_0B04880	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
HG537_0B04880	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
HG537_0B04890	COG4285	Biotin-protein ligase, N terminal
HG537_0B04900	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HG537_0B04910	COG0459	protein refolding
HG537_0B05080	COG0515	serine threonine protein kinase
HG537_0B05080	COG2815	serine threonine protein kinase
HG537_0B05100	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
HG537_0B05150	COG1793	dna ligase
HG537_0B05320	COG0067	glutamate synthase
HG537_0B05320	COG0070	glutamate synthase
HG537_0B05320	COG0069	glutamate synthase activity
HG537_0B05350	COG0277	FAD linked oxidase domain protein
HG537_0B05400	COG0442	prolyl-tRNA aminoacylation
HG537_0B05500	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
HG537_0B05570	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
HG537_0B05590	COG0450	alkyl hydroperoxide reductase
HG537_0B05620	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HG537_0B05680	COG0443	Heat shock 70 kDa protein
HG537_0B05690	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
HG537_0B05760	COG0443	Heat shock 70 kDa protein
HG537_0B05780	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
HG537_0B05820	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HG537_0B05900	COG0228	four-way junction DNA binding
HG537_0B05980	COG0513	Belongs to the DEAD box helicase family
HG537_0B05990	COG0101	tRNA pseudouridine synthase activity
HG537_0B06090	COG0006	proline dipeptidase activity
HG537_0B06200	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
HG537_0B06250	COG1196	nuclear chromosome segregation
HG537_0B06280	COG0833	amino acid
HG537_0B06340	COG0484	heat shock protein binding
HG537_0B06390	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HG537_0B06430	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
HG537_0B06580	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
HG537_0B06610	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
HG537_0B06720	COG5277	cytoskeleton organization
HG537_0B06730	COG2814	Major facilitator Superfamily
HG537_0B06760	COG1028	Short-chain dehydrogenase reductase Sdr
HG537_0B06780	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HG537_0B06790	COG2132	Multicopper oxidase
HG537_0B06800	COG1063	alcohol dehydrogenase
HG537_0B07000	COG0667	Aldo Keto reductase
HG537_0B07010	COG2249	NAD(P)H dehydrogenase (quinone) activity
HG537_0B07070	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HG537_0C00150	COG2814	Major facilitator Superfamily
HG537_0C00160	COG2017	converts alpha-aldose to the beta-anomer
HG537_0C00210	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
HG537_0C00330	COG0484	heat shock protein binding
HG537_0C00380	COG0402	S-adenosylhomocysteine deaminase activity
HG537_0C00410	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
HG537_0C00440	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
HG537_0C00460	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
HG537_0C00590	COG0443	Heat shock 70 kDa protein
HG537_0C00660	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
HG537_0C00660	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
HG537_0C00860	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
HG537_0C00920	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
HG537_0C01000	COG0166	Belongs to the GPI family
HG537_0C01050	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HG537_0C01230	COG1012	belongs to the aldehyde dehydrogenase family
HG537_0C01330	COG0505	Belongs to the CarA family
HG537_0C01430	COG0328	RNA-DNA hybrid ribonuclease activity
HG537_0C01520	COG0539	negative regulation of cytoplasmic translation
HG537_0C01550	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HG537_0C01560	COG4221	oxidoreductase activity
HG537_0C01630	COG0406	alpha-ribazole phosphatase activity
HG537_0C01750	COG0518	GMP synthase (glutamine-hydrolyzing) activity
HG537_0C01750	COG0519	Catalyzes the synthesis of GMP from XMP
HG537_0C01770	COG0484	heat shock protein binding
HG537_0C01820	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
HG537_0C01830	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HG537_0C01900	COG1160	GTP binding
HG537_0C01920	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HG537_0C01930	COG0386	Belongs to the glutathione peroxidase family
HG537_0C01950	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HG537_0C01980	COG2814	Major facilitator Superfamily
HG537_0C02000	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HG537_0C02000	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HG537_0C02050	COG0513	Belongs to the DEAD box helicase family
HG537_0C02130	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
HG537_0C02170	COG0672	)-iron permease
HG537_0C02250	COG1612	heme a metabolic process
HG537_0C02310	COG0156	8-amino-7-oxononanoate synthase activity
HG537_0C02320	COG1119	ATPase activity
HG537_0C02370	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
HG537_0C02370	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
HG537_0C02400	COG1012	belongs to the aldehyde dehydrogenase family
HG537_0C02410	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
HG537_0C02470	COG0515	serine threonine protein kinase
HG537_0C02480	COG0427	acetyl-CoA hydrolase
HG537_0C02510	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
HG537_0C02560	COG0123	including yeast histone deacetylase and acetoin utilization protein
HG537_0C02630	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HG537_0C02650	COG0626	cystathionine gamma-synthase activity
HG537_0C02800	COG5277	cytoskeleton organization
HG537_0C02810	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
HG537_0C02920	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
HG537_0C02980	COG1444	tRNA N-acetyltransferase activity
HG537_0C03100	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
HG537_0C03140	COG0291	Belongs to the bacterial ribosomal protein bL35 family
HG537_0C03200	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
HG537_0C03310	COG0513	Belongs to the DEAD box helicase family
HG537_0C03430	COG0417	DNA replication proofreading
HG537_0C03560	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
HG537_0C03600	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
HG537_0C03630	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
HG537_0C03670	COG0017	Asparaginyl-tRNA synthetase
HG537_0C03760	COG0443	Heat shock 70 kDa protein
HG537_0C03790	COG0542	response to heat
HG537_0C03800	COG0316	Belongs to the HesB IscA family
HG537_0C03810	COG2814	Major facilitator Superfamily
HG537_0C03930	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
HG537_0C03940	COG0724	RNA recognition motif
HG537_0C04020	COG0488	(ABC) transporter
HG537_0C04030	COG1058	Belongs to the CinA family
HG537_0C04030	COG1546	Belongs to the CinA family
HG537_0C04100	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
HG537_0C04120	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HG537_0C04120	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HG537_0C04200	COG2759	Belongs to the formate--tetrahydrofolate ligase family
HG537_0C04340	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HG537_0C04430	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
HG537_0C04450	COG1064	alcohol dehydrogenase
HG537_0C04540	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
HG537_0C04570	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
HG537_0C04580	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
HG537_0C04690	COG0133	tryptophan synthase activity
HG537_0C04890	COG1335	isochorismatase
HG537_0C04970	COG0833	amino acid
HG537_0C04990	COG0724	RNA recognition motif
HG537_0C05040	COG1859	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase
HG537_0C05080	COG2814	Major facilitator Superfamily
HG537_0C05150	COG0200	Binds to the 23S rRNA
HG537_0C05210	COG0367	asparagine synthase
HG537_0C05220	COG0659	secondary active sulfate transmembrane transporter activity
HG537_0C05370	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HG537_0C05440	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HG537_0C05480	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
HG537_0C05540	COG0418	dihydroorotase activity
HG537_0C05560	COG1546	Belongs to the CinA family
HG537_0C05560	COG1058	Belongs to the CinA family
HG537_0C05600	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
HG537_0C05650	COG1304	FMN binding
HG537_0C05780	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HG537_0C05830	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HG537_0C06170	COG0626	cystathionine gamma-synthase activity
HG537_0C06330	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HG537_0C06370	COG0460	homoserine dehydrogenase
HG537_0C06370	COG0527	aspartate kinase activity
HG537_0C06470	COG2815	serine threonine protein kinase
HG537_0C06470	COG0515	serine threonine protein kinase
HG537_0C06480	COG0745	RESPONSE REGULATOR receiver
HG537_0C06510	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
HG537_0C06520	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HG537_0C06540	COG0667	Aldo Keto reductase
HG537_0C06550	COG2249	NAD(P)H dehydrogenase (quinone) activity
HG537_0D00140	COG1902	pentaerythritol trinitrate reductase activity
HG537_0D00150	COG0798	PFAM Bile acid sodium symporter
HG537_0D00160	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
HG537_0D00170	COG2814	Major facilitator Superfamily
HG537_0D00210	COG0248	Ppx GppA phosphatase
HG537_0D00260	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
HG537_0D00310	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HG537_0D00370	COG0157	Belongs to the NadC ModD family
HG537_0D00430	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
HG537_0D00520	COG0484	heat shock protein binding
HG537_0D00550	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
HG537_0D00660	COG0488	(ABC) transporter
HG537_0D00760	COG0037	tRNA processing
HG537_0D00870	COG1183	phosphatidylcholine synthase activity
HG537_0D00890	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HG537_0D00900	COG0058	SHG alpha-glucan phosphorylase activity
HG537_0D00930	COG0517	IMP dehydrogenase activity
HG537_0D00930	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
HG537_0D00970	COG2814	Major facilitator Superfamily
HG537_0D01040	COG0039	L-malate dehydrogenase activity
HG537_0D01160	COG1643	Atp-dependent helicase
HG537_0D01170	COG0477	Major facilitator Superfamily
HG537_0D01170	COG2814	Major facilitator Superfamily
HG537_0D01180	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
HG537_0D01280	COG0443	Heat shock 70 kDa protein
HG537_0D01320	COG1956	GAF domain-containing protein
HG537_0D01420	COG0105	UTP biosynthetic process
HG537_0D01630	COG1028	Short-chain dehydrogenase reductase Sdr
HG537_0D01710	COG0191	fructose-bisphosphate aldolase activity
HG537_0D01760	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
HG537_0D01820	COG1231	oxidoreductase activity
HG537_0D01980	COG0012	GTP binding
HG537_0D02110	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
HG537_0D02210	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HG537_0D02240	COG0525	valine-tRNA ligase activity
HG537_0D02270	COG0515	serine threonine protein kinase
HG537_0D02410	COG0515	serine threonine protein kinase
HG537_0D02480	COG0724	RNA recognition motif
HG537_0D02570	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HG537_0D02570	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HG537_0D02600	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HG537_0D02640	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
HG537_0D02640	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
HG537_0D02680	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
HG537_0D03130	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
HG537_0D03190	COG0483	inositol monophosphate 1-phosphatase activity
HG537_0D03200	COG0482	sulfurtransferase activity
HG537_0D03210	COG0513	Belongs to the DEAD box helicase family
HG537_0D03270	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HG537_0D03290	COG4535	Mg2 and Co2 transporter CorC
HG537_0D03300	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
HG537_0D03310	COG0137	argininosuccinate synthase activity
HG537_0D03320	COG0588	phosphoglycerate mutase activity
HG537_0D03350	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
HG537_0D03360	COG0515	serine threonine protein kinase
HG537_0D03360	COG2815	serine threonine protein kinase
HG537_0D03370	COG0515	serine threonine protein kinase
HG537_0D03370	COG2815	serine threonine protein kinase
HG537_0D03400	COG0351	phosphomethylpyrimidine kinase
HG537_0D03400	COG0352	thiamine-phosphate diphosphorylase activity
HG537_0D03400	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
HG537_0D03420	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HG537_0D03440	COG3266	domain, Protein
HG537_0D03440	COG0515	serine threonine protein kinase
HG537_0D03510	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
HG537_0D03520	COG0135	phosphoribosylanthranilate isomerase activity
HG537_0D03600	COG1012	belongs to the aldehyde dehydrogenase family
HG537_0D03630	COG0142	geranyltranstransferase activity
HG537_0D03640	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
HG537_0D03740	COG0355	proton-transporting ATP synthase activity, rotational mechanism
HG537_0D03770	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HG537_0D03780	COG0842	Transport permease protein
HG537_0D03780	COG1716	ATPase activity
HG537_0D03780	COG1131	(ABC) transporter
HG537_0D03790	COG1953	Uracil, thiamine, allantoin
HG537_0D03830	COG1999	signal sequence binding
HG537_0D03890	COG0515	serine threonine protein kinase
HG537_0D03900	COG0575	Belongs to the CDS family
HG537_0D03920	COG0088	Forms part of the polypeptide exit tunnel
HG537_0D03960	COG0259	pyridoxamine-phosphate oxidase activity
HG537_0D04000	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
HG537_0D04020	COG0318	PFAM AMP-dependent synthetase and ligase
HG537_0D04050	COG0404	The glycine cleavage system catalyzes the degradation of glycine
HG537_0D04060	COG0459	protein refolding
HG537_0D04070	COG0572	uridine kinase
HG537_0D04100	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
HG537_0D04200	COG0655	NAD(P)H dehydrogenase (quinone) activity
HG537_0D04260	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HG537_0D04290	COG1024	Enoyl-CoA hydratase
HG537_0D04310	COG2815	serine threonine protein kinase
HG537_0D04310	COG0515	serine threonine protein kinase
HG537_0D04330	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
HG537_0D04340	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
HG537_0D04350	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
HG537_0D04360	COG0051	transcription antitermination factor activity, RNA binding
HG537_0D04410	COG0408	coproporphyrinogen oxidase activity
HG537_0D04450	COG0149	triose-phosphate isomerase activity
HG537_0D04510	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
HG537_0D04590	COG0154	amidase activity
HG537_0D04620	COG1222	aaa ATPase
HG537_0D04780	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
HG537_0D04870	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HG537_0D04900	COG0217	transcriptional regulatory protein
HG537_0D04970	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HG537_0D05030	COG1643	Atp-dependent helicase
HG537_0D05060	COG1022	Amp-dependent synthetase and ligase
HG537_0D05080	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HG537_0D05110	COG0756	dUTP diphosphatase activity
HG537_0D05190	COG0307	riboflavin synthase, alpha
HG537_0D05230	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
HG537_0D05240	COG1196	nuclear chromosome segregation
HG537_0D05440	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HG537_0D05450	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HG537_0D05450	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HG537_0D05480	COG2815	serine threonine protein kinase
HG537_0D05480	COG0515	serine threonine protein kinase
HG537_0D05550	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HG537_0D05570	COG0484	heat shock protein binding
HG537_0D05620	COG2205	protein histidine kinase activity
HG537_0D05730	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
HG537_0D05750	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
HG537_0D05790	COG0251	oxidation-reduction process
HG537_0D05820	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HG537_0D05830	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HG537_0D05860	COG2224	Isocitrate lyase
HG537_0D05900	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
HG537_0D05950	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HG537_0D05950	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
HG537_0D06000	COG1012	belongs to the aldehyde dehydrogenase family
HG537_0D06070	COG0006	proline dipeptidase activity
HG537_0D06120	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HG537_0D06150	COG0167	dihydroorotate dehydrogenase activity
HG537_0D06190	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
HG537_0D06240	COG0277	FAD linked oxidase domain protein
HG537_0D06250	COG0537	adenosine 5'-monophosphoramidase activity
HG537_0D06280	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
HG537_0D06390	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
HG537_0D06450	COG0666	response to abiotic stimulus
HG537_0D06500	COG0563	adenylate kinase activity
HG537_0D06510	COG1028	Short-chain dehydrogenase reductase Sdr
HG537_0E00180	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
HG537_0E00180	COG4106	trans-aconitate 2-methyltransferase activity
HG537_0E00200	COG0415	Belongs to the DNA photolyase family
HG537_0E00290	COG0123	including yeast histone deacetylase and acetoin utilization protein
HG537_0E00300	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HG537_0E00380	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HG537_0E00420	COG1073	alpha beta
HG537_0E00440	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HG537_0E00480	COG0218	Necessary for normal cell division and for the maintenance of normal septation
HG537_0E00500	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
HG537_0E00510	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HG537_0E00570	COG0018	arginyl-trna synthetase
HG537_0E00580	COG2814	Major facilitator Superfamily
HG537_0E00590	COG2814	Major facilitator Superfamily
HG537_0E00600	COG2814	Major facilitator Superfamily
HG537_0E00610	COG0477	Major facilitator Superfamily
HG537_0E00610	COG2814	Major facilitator Superfamily
HG537_0E00740	COG0656	L-ascorbic acid biosynthetic process
HG537_0E00860	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HG537_0E00880	COG0626	cystathionine gamma-synthase activity
HG537_0E00890	COG1362	aminopeptidase activity
HG537_0E00910	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
HG537_0E00990	COG0656	L-ascorbic acid biosynthetic process
HG537_0E01040	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HG537_0E01090	COG0450	alkyl hydroperoxide reductase
HG537_0E01100	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
HG537_0E01230	COG0515	serine threonine protein kinase
HG537_0E01230	COG2815	serine threonine protein kinase
HG537_0E01270	COG0047	phosphoribosylformylglycinamidine synthase activity
HG537_0E01270	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HG537_0E01380	COG0443	Heat shock 70 kDa protein
HG537_0E01530	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
HG537_0E01550	COG2365	Tyrosine phosphatase family
HG537_0E01580	COG0495	leucyl-tRNA aminoacylation
HG537_0E01590	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
HG537_0E01770	COG0538	isocitrate dehydrogenase activity
HG537_0E01820	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HG537_0E01840	COG4581	dead DEAH box helicase
HG537_0E01920	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HG537_0E02010	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HG537_0E02030	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
HG537_0E02050	COG0019	diaminopimelate decarboxylase activity
HG537_0E02090	COG4178	(ABC) transporter
HG537_0E02130	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
HG537_0E02150	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
HG537_0E02350	COG0039	L-malate dehydrogenase activity
HG537_0E02360	COG0670	Belongs to the BI1 family
HG537_0E02380	COG0089	rRNA binding
HG537_0E02580	COG2814	Major facilitator Superfamily
HG537_0E02640	COG0556	nucleotide-excision repair
HG537_0E02650	COG0515	serine threonine protein kinase
HG537_0E02650	COG2815	serine threonine protein kinase
HG537_0E02900	COG1657	PFAM Prenyltransferase squalene oxidase
HG537_0E02970	COG2226	methyltransferase
HG537_0E03050	COG0443	Heat shock 70 kDa protein
HG537_0E03060	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
HG537_0E03230	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
HG537_0E03320	COG1012	belongs to the aldehyde dehydrogenase family
HG537_0E03330	COG0557	exoribonuclease II activity
HG537_0E03400	COG1111	helicase
HG537_0E03400	COG1205	dead DEAH box helicase
HG537_0E03480	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
HG537_0E03570	COG1914	H( )-stimulated, divalent metal cation uptake system
HG537_0E03630	COG0534	Mate efflux family protein
HG537_0E03640	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HG537_0E03670	COG1506	peptidase
HG537_0E03670	COG0823	Involved in the tonB-independent uptake of proteins
HG537_0E03700	COG0083	homoserine kinase activity
HG537_0E03710	COG0612	Peptidase, M16
HG537_0E03820	COG0588	phosphoglycerate mutase activity
HG537_0E03830	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
HG537_0E03860	COG1053	succinate dehydrogenase
HG537_0E03880	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HG537_0E03930	COG0459	protein refolding
HG537_0E04000	COG0443	Heat shock 70 kDa protein
HG537_0E04050	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HG537_0E04360	COG0513	Belongs to the DEAD box helicase family
HG537_0E04520	COG0180	Tryptophanyl-tRNA synthetase
HG537_0E04640	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HG537_0E04650	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
HG537_0E04670	COG0477	Major facilitator Superfamily
HG537_0E04680	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HG537_0E04700	COG0688	phosphatidylethanolamine metabolic process
HG537_0E04740	COG0564	pseudouridine synthase activity
HG537_0E04820	COG0459	protein refolding
HG537_0E04830	COG0515	serine threonine protein kinase
HG537_0E04880	COG1185	polyribonucleotide nucleotidyltransferase activity
HG537_0E04910	COG2046	Belongs to the sulfate adenylyltransferase family
HG537_0E04910	COG0529	Catalyzes the synthesis of activated sulfate
HG537_0E04920	COG0508	dehydrogenase complex catalyzes the overall conversion of
HG537_0E05090	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HG537_0E05100	COG2759	Belongs to the formate--tetrahydrofolate ligase family
HG537_0E05110	COG1946	Acyl-CoA thioesterase
HG537_0E05150	COG0235	Class ii aldolase
HG537_0E05160	COG0662	Cupin 2, conserved barrel domain protein
HG537_0E05190	COG0560	Phosphoserine phosphatase
HG537_0E05200	COG0492	ferredoxin-NADP+ reductase activity
HG537_0E05200	COG3118	belongs to the thioredoxin family
HG537_0E05230	COG3961	Belongs to the TPP enzyme family
HG537_0E05240	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
HG537_0E05360	COG0222	ribosome binding
HG537_0E05370	COG2815	serine threonine protein kinase
HG537_0E05370	COG0515	serine threonine protein kinase
HG537_0E05390	COG2816	NAD+ diphosphatase activity
HG537_0E05460	COG0515	serine threonine protein kinase
HG537_0E05460	COG2815	serine threonine protein kinase
HG537_0E05470	COG0513	Belongs to the DEAD box helicase family
HG537_0E05550	COG0352	thiamine-phosphate diphosphorylase activity
HG537_0E05660	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
HG537_0E05730	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
HG537_0E05750	COG1132	(ABC) transporter
HG537_0E05760	COG2873	o-acetylhomoserine
HG537_0E05800	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HG537_0E05830	COG2271	Major facilitator Superfamily
HG537_0E05860	COG2814	Major facilitator Superfamily
HG537_0E05900	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HG537_0E05930	COG0833	amino acid
HG537_0E05940	COG0656	L-ascorbic acid biosynthetic process
HG537_0E05980	COG2017	converts alpha-aldose to the beta-anomer
HG537_0E05990	COG2814	Major facilitator Superfamily
HG537_0F00170	COG0626	cystathionine gamma-synthase activity
HG537_0F00290	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
HG537_0F00300	COG0515	serine threonine protein kinase
HG537_0F00400	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
HG537_0F00420	COG3118	belongs to the thioredoxin family
HG537_0F00470	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
HG537_0F00490	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
HG537_0F00570	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HG537_0F00570	COG0512	Glutamine amidotransferase of anthranilate synthase
HG537_0F00600	COG0515	serine threonine protein kinase
HG537_0F00600	COG2815	serine threonine protein kinase
HG537_0F00610	COG4249	Peptidase C14 caspase catalytic subunit p20
HG537_0F00610	COG2319	Wd-40 repeat
HG537_0F00650	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HG537_0F00670	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
HG537_0F00910	COG4770	biotin carboxylase activity
HG537_0F00960	COG0572	uridine kinase
HG537_0F01150	COG0633	Ferredoxin
HG537_0F01220	COG0227	Belongs to the bacterial ribosomal protein bL28 family
HG537_0F01250	COG0514	ATP-dependent DNA helicase (RecQ)
HG537_0F01260	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HG537_0F01260	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HG537_0F01280	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
HG537_0F01360	COG0326	Molecular chaperone. Has ATPase activity
HG537_0F01410	COG0515	serine threonine protein kinase
HG537_0F01420	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
HG537_0F01460	COG0736	holo-[acyl-carrier-protein] synthase activity
HG537_0F01550	COG0515	serine threonine protein kinase
HG537_0F01610	COG0109	protoheme IX farnesyltransferase activity
HG537_0F01630	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HG537_0F01730	COG0484	heat shock protein binding
HG537_0F01770	COG0417	DNA replication proofreading
HG537_0F01800	COG2897	thiosulfate sulfurtransferase activity
HG537_0F01870	COG1028	Short-chain dehydrogenase reductase Sdr
HG537_0F01880	COG0495	leucyl-tRNA aminoacylation
HG537_0F01990	COG0585	pseudouridine synthase activity
HG537_0F02010	COG0285	dihydrofolate synthase activity
HG537_0F02020	COG0515	serine threonine protein kinase
HG537_0F02020	COG2815	serine threonine protein kinase
HG537_0F02090	COG3842	ATPase activity
HG537_0F02160	COG2815	serine threonine protein kinase
HG537_0F02160	COG0515	serine threonine protein kinase
HG537_0F02170	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
HG537_0F02180	COG2815	serine threonine protein kinase
HG537_0F02180	COG0515	serine threonine protein kinase
HG537_0F02230	COG0822	iron-sulfur transferase activity
HG537_0F02290	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
HG537_0F02330	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HG537_0F02450	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
HG537_0F02560	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HG537_0F02560	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
HG537_0F02570	COG0513	Belongs to the DEAD box helicase family
HG537_0F02600	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HG537_0F02610	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
HG537_0F02640	COG0123	including yeast histone deacetylase and acetoin utilization protein
HG537_0F02650	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
HG537_0F02820	COG0443	Heat shock 70 kDa protein
HG537_0F02880	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
HG537_0F02890	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
HG537_0F03020	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
HG537_0F03050	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HG537_0F03140	COG2217	Heavy metal translocating P-type atpase
HG537_0F03170	COG0180	Tryptophanyl-tRNA synthetase
HG537_0F03380	COG0656	L-ascorbic acid biosynthetic process
HG537_0F03450	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HG537_0F03580	COG0489	protein tyrosine kinase activity
HG537_0F03670	COG0724	RNA recognition motif
HG537_0F03770	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
HG537_0F03810	COG0484	heat shock protein binding
HG537_0F03890	COG0842	Transport permease protein
HG537_0F03890	COG1131	(ABC) transporter
HG537_0F03890	COG1716	ATPase activity
HG537_0F04030	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
HG537_0F04140	COG1196	nuclear chromosome segregation
HG537_0F04150	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HG537_0F04180	COG0626	cystathionine gamma-synthase activity
HG537_0F04250	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
HG537_0F04350	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HG537_0F04440	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
HG537_0F04570	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
HG537_0F04640	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
HG537_0F04650	COG3266	domain, Protein
HG537_0F04650	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
HG537_0F04660	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
HG537_0F04690	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HG537_0F04700	COG0469	pyruvate kinase activity
HG537_0F04710	COG1113	amino acid transport
HG537_0F04910	COG0509	glycine decarboxylation via glycine cleavage system
HG537_0F05100	COG1012	belongs to the aldehyde dehydrogenase family
HG537_0F05130	COG1063	alcohol dehydrogenase
HG537_0F05140	COG1063	alcohol dehydrogenase
HG537_0F05150	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HG537_0F05160	COG4221	oxidoreductase activity
HG537_0G00120	COG0488	(ABC) transporter
HG537_0G00160	COG2271	Major facilitator Superfamily
HG537_0G00210	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
HG537_0G00220	COG1252	NADH dehydrogenase
HG537_0G00260	COG0477	Major facilitator Superfamily
HG537_0G00310	COG3425	synthase
HG537_0G00480	COG0571	ribonuclease III activity
HG537_0G00500	COG0483	inositol monophosphate 1-phosphatase activity
HG537_0G00520	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
HG537_0G00560	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HG537_0G00690	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
HG537_0G00830	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
HG537_0G00950	COG0076	glutamate decarboxylase activity
HG537_0G01050	COG1230	cation diffusion facilitator family transporter
HG537_0G01180	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
HG537_0G01200	COG1716	ATPase activity
HG537_0G01200	COG1131	(ABC) transporter
HG537_0G01200	COG0842	Transport permease protein
HG537_0G01240	COG2815	serine threonine protein kinase
HG537_0G01240	COG0515	serine threonine protein kinase
HG537_0G01360	COG1785	Belongs to the alkaline phosphatase family
HG537_0G01460	COG0724	RNA recognition motif
HG537_0G01470	COG0515	serine threonine protein kinase
HG537_0G01490	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
HG537_0G01570	COG0183	Belongs to the thiolase family
HG537_0G01620	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
HG537_0G01670	COG0513	Belongs to the DEAD box helicase family
HG537_0G01680	COG0154	amidase activity
HG537_0G01740	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
HG537_0G01790	COG0181	hydroxymethylbilane synthase activity
HG537_0G01800	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
HG537_0G01820	COG0156	8-amino-7-oxononanoate synthase activity
HG537_0G01870	COG0220	tRNA (guanine-N7-)-methyltransferase activity
HG537_0G01890	COG2814	Major facilitator Superfamily
HG537_0G01940	COG0563	adenylate kinase activity
HG537_0G02080	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
HG537_0G02110	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
HG537_0G02160	COG2226	methyltransferase
HG537_0G02200	COG0784	Response regulator, receiver
HG537_0G02200	COG5002	protein histidine kinase activity
HG537_0G02200	COG2205	protein histidine kinase activity
HG537_0G02230	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
HG537_0G02340	COG1028	Short-chain dehydrogenase reductase Sdr
HG537_0G02380	COG1643	Atp-dependent helicase
HG537_0G02430	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
HG537_0G02500	COG1234	tRNA 3'-trailer cleavage
HG537_0G02540	COG0435	Glutathione S-transferase
HG537_0G02550	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
HG537_0G02550	COG2857	Cytochrome c1
HG537_0G02570	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
HG537_0G02680	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
HG537_0G02810	COG0401	homolog of Blt101
HG537_0G02860	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HG537_0G02880	COG2119	membrane
HG537_0G02900	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HG537_0G02910	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HG537_0G02960	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
HG537_0G03000	COG0563	adenylate kinase activity
HG537_0G03010	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
HG537_0G03030	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
HG537_0G03030	COG0617	tRNA 3'-terminal CCA addition
HG537_0G03030	COG0517	IMP dehydrogenase activity
HG537_0G03090	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HG537_0G03100	COG1129	ABC transporter
HG537_0G03230	COG2351	hydroxyisourate hydrolase activity
HG537_0G03310	COG0706	membrane insertase activity
HG537_0G03330	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HG537_0G03490	COG1643	Atp-dependent helicase
HG537_0G03520	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
HG537_0G03580	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
HG537_0G03600	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
HG537_0G03630	COG0508	dehydrogenase complex catalyzes the overall conversion of
HG537_0G03630	COG0022	dehydrogenase e1 component
HG537_0G03790	COG0724	RNA recognition motif
HG537_0G03830	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HG537_0G03840	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
HG537_0G03870	COG0405	Gamma-glutamyltransferase
HG537_0G03880	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
HG537_0G03970	COG0481	GTPase activity
HG537_0G04070	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
HG537_0G04100	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
HG537_0G04160	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
HG537_0G04310	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HG537_0G04350	COG0459	protein refolding
HG537_0G04500	COG1357	PFAM Pentapeptide repeats (8 copies)
HG537_0G04500	COG0515	serine threonine protein kinase
HG537_0G04600	COG1741	Belongs to the pirin family
HG537_0G04710	COG0114	fumarate hydratase activity
HG537_0G04730	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HG537_0G04790	COG1132	(ABC) transporter
HG537_0G04830	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
HG537_0G04850	COG0833	amino acid
HG537_0G04870	COG1621	beta-fructofuranosidase activity
HG537_0G04890	COG1454	alcohol dehydrogenase
HG537_0G04910	COG0405	Gamma-glutamyltransferase
HG537_0G04960	COG0456	acetyltransferase
HG537_0G05020	COG0596	Alpha beta hydrolase
HG537_0G05030	COG1902	pentaerythritol trinitrate reductase activity
HG537_0H00150	COG2249	NAD(P)H dehydrogenase (quinone) activity
HG537_0H00160	COG0667	Aldo Keto reductase
HG537_0H00190	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
HG537_0H00230	COG0167	dihydroorotate dehydrogenase activity
HG537_0H00260	COG0183	Belongs to the thiolase family
HG537_0H00360	COG0459	protein refolding
HG537_0H00400	COG3844	kynureninase activity
HG537_0H00430	COG0551	DNA topoisomerase type I activity
HG537_0H00430	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HG537_0H00500	COG0321	lipoyl(octanoyl) transferase activity
HG537_0H00550	COG0513	Belongs to the DEAD box helicase family
HG537_0H00610	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
HG537_0H00650	COG0024	Methionine aminopeptidase
HG537_0H00660	COG0295	cytidine deaminase activity
HG537_0H00810	COG0612	Peptidase, M16
HG537_0H01040	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
HG537_0H01160	COG0833	amino acid
HG537_0H01280	COG0508	dehydrogenase complex catalyzes the overall conversion of
HG537_0H01520	COG1132	(ABC) transporter
HG537_0H01530	COG0515	serine threonine protein kinase
HG537_0H01530	COG2815	serine threonine protein kinase
HG537_0H01720	COG2267	carboxylic ester hydrolase activity
HG537_0H01760	COG2815	serine threonine protein kinase
HG537_0H01760	COG0515	serine threonine protein kinase
HG537_0H01810	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HG537_0H01830	COG2814	Major facilitator Superfamily
HG537_0H01870	COG0081	regulation of translation
HG537_0H01910	COG0484	heat shock protein binding
HG537_0H01960	COG1196	nuclear chromosome segregation
HG537_0H02080	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
HG537_0H02220	COG0004	ammonium transporteR
HG537_0H02400	COG3346	SURF1 family
HG537_0H02440	COG0596	Alpha beta hydrolase
HG537_0H02480	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
HG537_0H02570	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
HG537_0H02640	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HG537_0H02650	COG2815	serine threonine protein kinase
HG537_0H02650	COG0515	serine threonine protein kinase
HG537_0H02660	COG0488	(ABC) transporter
HG537_0H02690	COG0391	Required for morphogenesis under gluconeogenic growth conditions
HG537_0H02710	COG0538	isocitrate dehydrogenase activity
HG537_0H02720	COG0440	acetolactate synthase activity
HG537_0H02730	COG0211	Belongs to the bacterial ribosomal protein bL27 family
HG537_0H02750	COG0724	RNA recognition motif
HG537_0H02800	COG1104	cysteine desulfurase activity
HG537_0H02810	COG0473	3-isopropylmalate dehydrogenase activity
HG537_0H02850	COG0484	heat shock protein binding
HG537_0H02860	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
HG537_0H02980	COG0655	NAD(P)H dehydrogenase (quinone) activity
HG537_0H03050	COG1584	GPR1 FUN34 yaaH family protein
HG537_0H03090	COG0842	Transport permease protein
HG537_0H03090	COG1131	(ABC) transporter
HG537_0H03090	COG1716	ATPase activity
HG537_0H03100	COG0126	phosphoglycerate kinase activity
HG537_0H03170	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
HG537_0H03260	COG1028	Short-chain dehydrogenase reductase Sdr
HG537_0H03320	COG0017	Asparaginyl-tRNA synthetase
HG537_0H03330	COG0028	Belongs to the TPP enzyme family
HG537_0H03380	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HG537_0H03410	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HG537_0H03530	COG0009	L-threonylcarbamoyladenylate synthase
HG537_0H03550	COG0085	RNA polymerase activity
HG537_0H03560	COG2233	PERMEase
HG537_0H03820	COG2815	serine threonine protein kinase
HG537_0H03820	COG0515	serine threonine protein kinase
HG537_0H03840	COG3266	domain, Protein
HG537_0H03840	COG0515	serine threonine protein kinase
HG537_0H03860	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HG537_0H03920	COG0515	serine threonine protein kinase
HG537_0H03960	COG0481	GTPase activity
HG537_0H04030	COG0179	Fumarylacetoacetate (FAA) hydrolase
HG537_0H04040	COG2131	deaminase
HG537_0H04050	COG0688	phosphatidylethanolamine metabolic process
HG537_0H04080	COG0724	RNA recognition motif
HG537_0H04190	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
HG537_0H04280	COG0459	protein refolding
HG537_0H04320	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
HG537_0H04410	COG2226	methyltransferase
HG537_0H04430	COG1132	(ABC) transporter
HG537_0H04440	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HG537_0H04480	COG0512	Glutamine amidotransferase of anthranilate synthase
HG537_0H04480	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HG537_0H04520	COG0423	glycine-tRNA ligase activity
HG537_0H04570	COG0277	FAD linked oxidase domain protein
HG537_0H04580	COG2040	homocysteine
HG537_0H04590	COG0626	cystathionine gamma-synthase activity
HG537_0H04600	COG2808	Putative FMN-binding domain
HG537_0H04610	COG1017	nitric oxide dioxygenase activity
HG537_0H04610	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress