locus-tag class description Trebr_0001 ENOG4105CI4 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) Trebr_0002 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) Trebr_0003 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) Trebr_0005 ENOG4105VG0 50S ribosomal protein l34 Trebr_0006 ENOG41084M4 RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity) Trebr_0007 ENOG4105VAS Could be involved in insertion of integral membrane proteins into the membrane (By similarity) Trebr_0008 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins Trebr_0009 ENOG4108Z7S Single-stranded nucleic acid binding R3H domain-containing protein Trebr_0011 ENOG4107XH4 PPIases accelerate the folding of proteins (By similarity) Trebr_0016 ENOG4108ZG0 Ompa motb domain protein Trebr_0017 ENOG4105D2H Uronic isomerase Trebr_0018 ENOG4105CTX dehydratase Trebr_0019 ENOG4107QZW Altronate oxidoreductase Trebr_0020 ENOG410874W AraC family transcriptional regulator Trebr_0022 ENOG4105C50 Binding-protein-dependent transport systems, inner membrane component Trebr_0031 ENOG4105EIB trna rrna methyltransferase Trebr_0034 ENOG4108RE9 Phosphodiesterase Trebr_0035 ENOG4108ZF1 Transcriptional regulator, BadM Rrf2 family Trebr_0036 ENOG4105DY8 decarboxylase Trebr_0044 ENOG4105EQ7 Binding-protein-dependent transport systems, inner membrane component Trebr_0045 ENOG4105DRS transport system, permease Trebr_0048 ENOG4108JEB The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) Trebr_0052 ENOG4105CR5 Class II aldolase adducin family protein Trebr_0053 ENOG4105C5I Dehydrogenase Trebr_0058 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) Trebr_0059 ENOG4105JAB phenazine biosynthesis protein, phzf family Trebr_0062 ENOG4105CZG Phosphotransfer between the C1 and C5 carbon atoms of pentose (By similarity) Trebr_0063 ENOG4108I5U Uridine phosphorylase Trebr_0065 ENOG4105CGH 5'-nucleotidase Trebr_0066 ENOG4105ETE Transcriptional regulator (LacI family Trebr_0067 ENOG4108JQ9 ABC transporter Trebr_0068 ENOG4105UIB (ABC) transporter Trebr_0070 ENOG4105FCI Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity) Trebr_0071 ENOG4107TFB basic membrane Trebr_0072 ENOG4105MN5 HAD-superfamily hydrolase subfamily IA variant 3 Trebr_0078 ENOG4108UYN gCN5-related N-acetyltransferase Trebr_0081 ENOG4108W2W Trebr_0086 ENOG4105DXX methyltransferase Trebr_0087 ENOG4105CJ1 ABC, transporter Trebr_0092 ENOG4105CHZ Catalyzes the dehydration of D-mannonate (By similarity) Trebr_0093 ENOG4105CG6 trap dicarboxylate transporter dctm subunit Trebr_0094 ENOG4105XDZ Tripartite ATP-independent periplasmic transporter Trebr_0095 ENOG4105GQU Trap dicarboxylate transporter, dctp subunit Trebr_0096 ENOG4105CPQ Dehydrogenase Trebr_0097 ENOG4105CPQ Dehydrogenase Trebr_0098 ENOG4107XBN GntR Family Transcriptional Regulator Trebr_0099 ENOG4105CHR reductase Trebr_0102 ENOG4108VYJ response regulator receiver protein Trebr_0103 ENOG4105CMP catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity) Trebr_0104 ENOG4105BZU Histidine kinase Trebr_0105 ENOG4105CBS Chea signal transduction histidine kinase Trebr_0107 ENOG4108V3W Chemotaxis protein, CheW Trebr_0108 ENOG4108Z4W Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis (By similarity) Trebr_0115 ENOG4105J3I Trebr_0116 ENOG4105F8J Adenylate Guanylate cyclase Trebr_0118 ENOG4105CNT hydrolase family 2 Trebr_0119 ENOG4105CNT hydrolase family 2 Trebr_0123 ENOG4105WH1 Two component transcriptional regulator luxr family Trebr_0125 ENOG4105C0A alcohol dehydrogenase Trebr_0127 ENOG4105DET Rhamnulokinase Trebr_0130 ENOG4105NWF RbsD or FucU transport Trebr_0131 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator Trebr_0132 ENOG4105C2J ABC transporter Trebr_0133 ENOG4108HWV )-transporter Trebr_0135 ENOG4105VUF Transcriptional regulator Trebr_0136 ENOG4105C2V Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) Trebr_0140 ENOG4105CEM UPF0597 protein Trebr_0141 ENOG4105DUM transcriptional regulator, lysR family Trebr_0142 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) Trebr_0143 ENOG4105UEI Transcriptional Regulator AraC Family Trebr_0153 ENOG4105C3S Mate efflux family protein Trebr_0163 ENOG4105BZU Histidine kinase Trebr_0165 ENOG4105CK6 Two component transcriptional regulator (Winged helix family Trebr_0167 ENOG4105BZU Histidine kinase Trebr_0168 ENOG4105CK6 Two component transcriptional regulator (Winged helix family Trebr_0169 ENOG4105CVA phosphate Trebr_0170 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) Trebr_0171 ENOG4108IG5 Transcriptional regulator Trebr_0172 ENOG4108UQY Iron-storage protein Trebr_0173 ENOG4105C8U phosphate abc transporter Trebr_0174 ENOG4105E2Z phosphate ABC transporter (Permease Trebr_0179 ENOG4105ECC imidazole-glycerol-phosphate dehydratase Trebr_0180 ENOG4105E21 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) Trebr_0189 ENOG4105C50 Binding-protein-dependent transport systems, inner membrane component Trebr_0191 ENOG4105C71 hydrolase family 65, central catalytic Trebr_0192 ENOG4107URF beta-phospho-glucomutase Trebr_0193 ENOG4105ETE Transcriptional regulator (LacI family Trebr_0194 ENOG4107YTP response regulator receiver protein Trebr_0197 ENOG4108W5M transcriptional regulator Trebr_0203 ENOG4105CV8 reductase Trebr_0209 ENOG4105CPC Aldo Keto reductase Trebr_0215 ENOG4105EC0 Required for nucleoid occlusion (NO) phenomenon, which prevents Z-ring formation and cell division over the nucleoid. Acts as a DNA-associated cell division inhibitor that binds simultaneously chromosomal DNA and FtsZ, and disrupts the assembly of FtsZ polymers. SlmA-DNA-binding sequences (SBS) are dispersed on non-Ter regions of the chromosome, preventing FtsZ polymerization at these regions (By similarity) Trebr_0221 ENOG4107RAN Peptidase, M16 Trebr_0223 ENOG4105BZ1 (ABC) transporter Trebr_0224 ENOG4105C5H ABC transporter Trebr_0227 ENOG4105C8Q Methyl-accepting chemotaxis Trebr_0229 ENOG4107XTC May be involved in the formation or repair of Fe-S clusters present in iron-sulfur proteins Trebr_0230 ENOG4108YZY peptidylprolyl cis-trans isomerase Trebr_0233 ENOG4108K0B C-di-gmp phosphodiesterase Trebr_0235 ENOG4105CIG ABC transporter Trebr_0237 ENOG4105CI1 PTS System Trebr_0238 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) Trebr_0239 ENOG4105KZ7 phosphocarrier protein hpr Trebr_0240 ENOG4105CID antiterminator Trebr_0241 ENOG4105CS2 ec 3.2.1.21 Trebr_0247 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain Trebr_0248 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain Trebr_0251 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) Trebr_0252 ENOG4105BZU Histidine kinase Trebr_0253 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) Trebr_0254 ENOG410841Q phosphoesterase PA-phosphatase related protein Trebr_0258 ENOG4108NVR Methyl-accepting chemotaxis Trebr_0259 ENOG4105C9M aspartyl-trna synthetase Trebr_0261 ENOG4108UI1 Probably functions as a manganese efflux pump (By similarity) Trebr_0262 ENOG4105ETE Transcriptional regulator (LacI family Trebr_0263 ENOG4105MRB Catalyzes the interconversion of beta-pyran and beta- furan forms of D-ribose (By similarity) Trebr_0264 ENOG4105C2J ABC transporter Trebr_0265 ENOG4105CNN ABC, transporter Trebr_0266 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator Trebr_0267 ENOG4108RVA ribokinase Trebr_0268 ENOG4107SDU Methyl-accepting chemotaxis Trebr_0269 ENOG4108V0P LemA family Trebr_0274 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) Trebr_0278 ENOG4105DTI Phosphonopyruvate decarboxylase Trebr_0282 ENOG4105F1A Pyruvate formate-lyase Trebr_0286 ENOG4105D5D udp-galactopyranose mutase Trebr_0288 ENOG4105K64 Glycosyl transferase, family 2 Trebr_0293 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase Trebr_0298 ENOG4108TJN glycosyl transferase group 1 Trebr_0301 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins Trebr_0306 ENOG4105CUU Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) Trebr_0308 ENOG4107MD5 glycoside hydrolase, family Trebr_0309 ENOG4105CHT Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) Trebr_0317 ENOG4105J7I hydrolase Trebr_0319 ENOG4105D1C Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion (By similarity) Trebr_0321 ENOG4105EQD regulatoR Trebr_0322 ENOG4105C2F Histidine kinase Trebr_0324 ENOG4105EQ7 Binding-protein-dependent transport systems, inner membrane component Trebr_0325 ENOG4105DRW binding-protein-dependent transport systems inner membrane Component Trebr_0327 ENOG4105CEY Amp-dependent synthetase and ligase Trebr_0330 ENOG410902H NADH dehydrogenase (Ubiquinone), 24 kDa subunit Trebr_0333 ENOG4107QIZ NADH dehydrogenase Trebr_0334 ENOG4107QHI -hydrogenase Trebr_0335 ENOG4105C8Q Methyl-accepting chemotaxis Trebr_0336 ENOG41069P5 Protein slyX homolog Trebr_0337 ENOG4105K95 (LipO)protein Trebr_0338 ENOG4105C2J ABC transporter Trebr_0342 ENOG4105CK6 Two component transcriptional regulator (Winged helix family Trebr_0343 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) Trebr_0344 ENOG4105GTN ParB Domain Protein Nuclease Trebr_0346 ENOG4105D64 Mechanosensitive ion channel Trebr_0347 ENOG4105CSM endonuclease III Trebr_0348 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP Trebr_0350 ENOG4107RY0 Catalyzes the conversion of dihydroorotate to orotate (By similarity) Trebr_0352 ENOG4105EZY Pyrroloquinoline quinone biosynthesis protein E Trebr_0356 ENOG4105CEC DNA methylase N-4 N-6 Trebr_0357 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) Trebr_0358 ENOG4105C7J ABC transporter, permease Trebr_0364 ENOG4105CFI type iii restriction protein res subunit Trebr_0365 ENOG4105T73 Trebr_0369 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) Trebr_0370 ENOG4107QYD Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) Trebr_0371 ENOG4105C1B dTDP-glucose 4-6-dehydratase Trebr_0373 ENOG4108URP Dtdp-4-dehydrorhamnose 3,5-epimerase Trebr_0375 ENOG4105FA0 parb-like partition protein Trebr_0376 ENOG4107QJE Chromosome Partitioning Protein Trebr_0384 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase Trebr_0386 ENOG4105CH6 catalase Trebr_0387 ENOG4107QN2 dihydrolipoyl dehydrogenase Trebr_0389 ENOG4105M78 Catalyzes, although with low efficiency, the sulfur transfer reaction from thiosulfate to cyanide (By similarity) Trebr_0390 ENOG4107UH8 sugar kinase Trebr_0393 ENOG4105HF9 Inherit from COG: pyridine nucleotide-disulfide oxidoreductase Trebr_0395 ENOG4105BZU Histidine kinase Trebr_0396 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase Trebr_0397 ENOG4108HMR Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) Trebr_0400 ENOG4105BZU Histidine kinase Trebr_0401 ENOG4105C12 Phosphoribosylglycinamide synthetase Trebr_0414 ENOG4105C3S Mate efflux family protein Trebr_0415 ENOG4107RWR Sodium hydrogen exchanger Trebr_0416 ENOG4105UQX Mate efflux family protein Trebr_0417 ENOG4105CAG UPF0210 protein Trebr_0418 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) Trebr_0421 ENOG4105ETE Transcriptional regulator (LacI family Trebr_0422 ENOG4105EPJ extracellular solute-binding protein family 1 Trebr_0423 ENOG4105S9S Binding-protein-dependent transport systems, inner membrane component Trebr_0424 ENOG4105EB1 binding-protein-dependent transport systems inner membrane Component Trebr_0427 ENOG4105EG2 ABC transporter, permease Trebr_0438 ENOG4108RYC glycosyltransferase Trebr_0439 ENOG4105CTC Lipopolysaccharide biosynthesis protein-like protein Trebr_0443 ENOG4105C4A Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity) Trebr_0444 ENOG4105CMR udp-glucose 4-epimerase Trebr_0449 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) Trebr_0451 ENOG4105C0P Mg chelatase subunit ChlI Trebr_0452 ENOG4105ETE Transcriptional regulator (LacI family Trebr_0453 ENOG4105DB7 PHP domain protein Trebr_0454 ENOG410870F Cyclic nucleotide-binding protein Trebr_0455 ENOG41063TF transcriptional regulator (AraC Trebr_0457 ENOG4105C8Q Methyl-accepting chemotaxis Trebr_0459 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase Trebr_0460 ENOG4105C3N Participates in control of cell volume in low-osmolarity conditions (By similarity) Trebr_0461 ENOG4105C5H ABC transporter Trebr_0463 ENOG4106KR7 LysR family Transcriptional regulator Trebr_0464 ENOG4107AYK membrAne Trebr_0466 ENOG4105DIQ Transcriptional regulator Trebr_0468 ENOG4105C50 Binding-protein-dependent transport systems, inner membrane component Trebr_0471 ENOG4105BZ1 (ABC) transporter Trebr_0473 ENOG4105DKW ABC transporter Trebr_0474 ENOG4105VRS hydrolase family 18 Trebr_0477 ENOG4105CGK Exodeoxyribonuclease III Trebr_0478 ENOG4105C70 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) Trebr_0483 ENOG4107R2U Catalyzes the formation of dTMP and tetrahydrofolate from dUMP and methylenetetrahydrofolate (By similarity) Trebr_0486 ENOG4105CY0 Metallo-Beta-Lactamase Trebr_0487 ENOG4105CTQ phosphohexokinase Trebr_0489 ENOG4105CD3 dihydroorotase Trebr_0494 ENOG4105UQX Mate efflux family protein Trebr_0498 ENOG4105MQ3 flagellar protein FliS Trebr_0499 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) Trebr_0501 ENOG4105VUC UPF0237 protein Trebr_0502 ENOG4105C4Q deoxyguanosinetriphosphate triphosphohydrolase-like protein Trebr_0505 ENOG4105C8Q Methyl-accepting chemotaxis Trebr_0508 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit Trebr_0512 ENOG4105VAW lrga family Trebr_0514 ENOG4107SDU Methyl-accepting chemotaxis Trebr_0520 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) Trebr_0525 ENOG4105C4R Atp-dependent dna helicase Trebr_0526 ENOG4105CBM Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 (By similarity) Trebr_0529 ENOG4105CPN adenine deaminase Trebr_0537 ENOG4108HWW ABC transporter Trebr_0539 ENOG4105DFW ABC transporter Trebr_0540 ENOG4105DFW ABC transporter Trebr_0541 ENOG4105EQD regulatoR Trebr_0541 ENOG4105EQD regulatoR Trebr_0542 ENOG4105C2F Histidine kinase Trebr_0544 ENOG41086D8 Transcriptional regulator Trebr_0547 ENOG4108V7D UPF0397 protein Trebr_0549 ENOG4105DC1 bifunctional purine biosynthesis protein purh Trebr_0550 ENOG4105CPY First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) Trebr_0551 ENOG4105I76 (LipO)protein Trebr_0552 ENOG4105C5H ABC transporter Trebr_0554 ENOG4105CMR udp-glucose 4-epimerase Trebr_0555 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) Trebr_0559 ENOG4105CFP Peptidase U32 Trebr_0560 ENOG4108SP1 single-stranded DNA-binding protein Trebr_0563 ENOG4105E2M Manganese-dependent inorganic pyrophosphatase Trebr_0565 ENOG4107SBB 4-alpha-glucanotransferase (EC 2.4.1.25) Trebr_0566 ENOG4105C34 Pseudouridine synthase Trebr_0567 ENOG4107QIV Cytochrome c biogenesis protein Trebr_0570 ENOG4108SSC basic membrane Trebr_0572 ENOG4108TWB ABC transporter (Permease Trebr_0573 ENOG4108ZV0 ABC transporter, permease Trebr_0575 ENOG4105C8Q Methyl-accepting chemotaxis Trebr_0576 ENOG4105DK7 lysyl-tRNA synthetase Trebr_0577 ENOG4105C1J atp-dependent rna helicase Trebr_0588 ENOG4107RE5 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) Trebr_0589 ENOG4105EKD Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity) Trebr_0590 ENOG4105DPN Oligoendopeptidase f Trebr_0591 ENOG4105C9U ATP-dependent DNA helicase RecQ Trebr_0592 ENOG4107QKZ Ompa motb domain protein Trebr_0594 ENOG4105BZU Histidine kinase Trebr_0595 ENOG4107RUE extracellular solute-binding protein family 1 Trebr_0596 ENOG4105D38 putrescine abc transporter Trebr_0597 ENOG4105F38 ABC transporter, permease Trebr_0598 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) Trebr_0600 ENOG4105KMT branched-chain amino acid Trebr_0601 ENOG4108UMN azlc family Trebr_0602 ENOG4105CG3 alpha amylase, catalytic region Trebr_0604 ENOG4105DXN mazG family Trebr_0605 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) Trebr_0606 ENOG4108S10 Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) Trebr_0608 ENOG41062BZ domain protein Trebr_0611 ENOG4106W1H Trebr_0614 ENOG4105CDA abc transporter atp-binding protein Trebr_0615 ENOG4105EAD ABC transporter Trebr_0616 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) Trebr_0618 ENOG4105D9Q decarboxylase (Beta subunit) Trebr_0623 ENOG4105D1H recombination factor protein RarA Trebr_0626 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) Trebr_0627 ENOG4105DZA Converts GTP to 7,8-dihydroneopterin triphosphate (By similarity) Trebr_0629 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) Trebr_0633 ENOG4108D32 Methyltransferase Trebr_0634 ENOG4108UM5 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity) Trebr_0635 ENOG4108UJD 30S ribosomal protein S9 Trebr_0636 ENOG410691R Modulates RecA activity (By similarity) Trebr_0637 ENOG4108KXV response regulator Trebr_0640 ENOG4107SGM protein serine threonine phosphatase Trebr_0641 ENOG4105D07 Signal peptide peptidase, SppA Trebr_0644 ENOG4105HCZ Trebr_0646 ENOG4105W4W Transcriptional regulator Trebr_0647 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) Trebr_0648 ENOG4107QK3 aspartate-semialdehyde dehydrogenase (EC 1.2.1.11 Trebr_0652 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) Trebr_0655 ENOG4105CXB phosphoribosylaminoimidazole synthetase Trebr_0656 ENOG4108V3E phosphoribosylglycinamide formyltransferase Trebr_0657 ENOG4105C6Z Gluconate Trebr_0659 ENOG4105G63 Type III effector Hrp-dependent Trebr_0660 ENOG4105E98 transcriptional regulator DeoR family Trebr_0663 ENOG4107QW8 radical SAM domain protein Trebr_0665 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family Trebr_0666 ENOG4105CZV ABC transporter Trebr_0668 ENOG4105CIH Imidazole acetol-phosphate transaminase Trebr_0670 ENOG4105DZS Phenylacetate-CoA ligase Trebr_0674 ENOG4105EYU Glutamine amido-transferase Trebr_0675 ENOG4105CBC glutamate synthase Trebr_0679 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) Trebr_0680 ENOG4107R2I The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation Trebr_0684 ENOG4105CG3 alpha amylase, catalytic region Trebr_0685 ENOG4108IUM Glycogen debranching enzyme Trebr_0686 ENOG4107FKK extracellular solute-binding protein family 1 Trebr_0688 ENOG4105EG2 ABC transporter, permease Trebr_0689 ENOG4105CG3 alpha amylase, catalytic region Trebr_0693 ENOG4105CAQ asparagine synthetase Trebr_0694 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) Trebr_0695 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase Trebr_0696 ENOG4105CHR reductase Trebr_0697 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) Trebr_0703 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) Trebr_0704 ENOG4108UTW Plays a role in the regulation of phosphate uptake Trebr_0706 ENOG4105D5T phosphonate abc transporter Trebr_0710 ENOG4105CNW domain protein Trebr_0712 ENOG4108HRK Histidine kinase Trebr_0713 ENOG4108UYB regulatoR Trebr_0714 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit Trebr_0716 ENOG4105CG6 trap dicarboxylate transporter dctm subunit Trebr_0717 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit Trebr_0718 ENOG4105E4Y Endoribonuclease that initiates mRNA decay (By similarity) Trebr_0719 ENOG4105BZU Histidine kinase Trebr_0720 ENOG4105CMP catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity) Trebr_0723 ENOG4105EAH synthase Trebr_0724 ENOG4105F7M Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit (By similarity) Trebr_0725 ENOG4105E4C Lytic transglycosylase catalytic Trebr_0726 ENOG4108IMY Transcriptional regulator Trebr_0727 ENOG41090QR Trebr_0728 ENOG4105C7K acetolactate synthase Trebr_0729 ENOG4105CC8 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) Trebr_0736 ENOG4105CPF Cell wall formation (By similarity) Trebr_0739 ENOG4105D9U N-acetyltransferase Trebr_0746 ENOG4108RT7 Glycosyl transferase, family 2 Trebr_0751 ENOG4105C0S IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity) Trebr_0752 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) Trebr_0753 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) Trebr_0754 ENOG4108UMW Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) Trebr_0755 ENOG4108HW3 (ABC) transporter Trebr_0756 ENOG4105DZ1 carboxypeptidase Trebr_0757 ENOG4105C01 Dihydroxy-acid dehydratase Trebr_0758 ENOG4105C7K acetolactate synthase Trebr_0759 ENOG4107QSS Involved in the synthesis of meso-diaminopimelate (m-DAP or DL-DAP), required for both lysine and peptidoglycan biosynthesis. Catalyzes the direct conversion of tetrahydrodipicolinate to LL-diaminopimelate, a reaction that requires three enzymes in E.coli (By similarity) Trebr_0762 ENOG4105CBS Chea signal transduction histidine kinase Trebr_0763 ENOG4105YFD chemotaxis, protein Trebr_0765 ENOG4107Z9R response regulator Trebr_0767 ENOG4105DRH Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) Trebr_0768 ENOG4105CAP With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P (By similarity) Trebr_0769 ENOG4105CB3 Required for the thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32) (By similarity) Trebr_0771 ENOG4105BZU Histidine kinase Trebr_0772 ENOG4105C3G gtp-binding protein Trebr_0778 ENOG4108ZBE Binds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F). Phosphorylates SpoIIAA on a serine residue. This phosphorylation may enable SpoIIAA to act as an anti-anti-sigma factor that counteracts SpoIIAB and thus releases sigma F from inhibition (By similarity) Trebr_0780 ENOG4105CPI Metal Dependent Phosphohydrolase Trebr_0782 ENOG4105D9H Catalyzes the attachment of glycine to tRNA(Gly) (By similarity) Trebr_0784 ENOG41084P6 50S ribosomal protein l28 Trebr_0785 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) Trebr_0787 ENOG4105DAP Nicotinate phosphoribosyltransferase Trebr_0788 ENOG4105CYX Short-chain dehydrogenase reductase Sdr Trebr_0789 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) Trebr_0790 ENOG4107Z25 Basic membrane protein Trebr_0791 ENOG4105M7K Involved in the transcription termination process (By similarity) Trebr_0793 ENOG4105K5Y Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity) Trebr_0794 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) Trebr_0795 ENOG4105CB5 ATP-dependent DNA helicase recG Trebr_0796 ENOG41067XK integral membrane protein Trebr_0797 ENOG4105C0B DNA polymerase III (alpha subunit) Trebr_0798 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) Trebr_0799 ENOG4108UMI ABC transporter, permease Trebr_0800 ENOG4105D01 (LipO)protein Trebr_0802 ENOG4105BZU Histidine kinase Trebr_0808 ENOG4105EJZ Glucose-1-phosphate cytidylyltransferase Trebr_0809 ENOG4105FAW cDP-glucose 4,6-dehydratase Trebr_0810 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase Trebr_0811 ENOG4105C7K acetolactate synthase Trebr_0812 ENOG4105DF3 Catalyzes the retro-aldol cleavage of 4-hydroxy-2- oxopentanoate to pyruvate and acetaldehyde. Is involved in the meta-cleavage pathway for the degradation of aromatic compounds (By similarity) Trebr_0813 ENOG4105D49 3-dehydroquinate synthase Trebr_0814 ENOG4105C1B dTDP-glucose 4-6-dehydratase Trebr_0816 ENOG4107YYJ Glycosyl transferase, family 2 Trebr_0819 ENOG4105CTC Lipopolysaccharide biosynthesis protein-like protein Trebr_0824 ENOG4105C22 threonyL-tRNA synthetase Trebr_0829 ENOG4105VIE preprotein translocase, subunit YajC Trebr_0830 ENOG4107QN8 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) Trebr_0831 ENOG4107XHD Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) Trebr_0832 ENOG4105C48 Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity) Trebr_0833 ENOG4108UIN ybak prolyl-trna synthetase associated region Trebr_0834 ENOG4105BZA Phosphoglycerate kinase Trebr_0836 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) Trebr_0839 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) Trebr_0840 ENOG4109003 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity) Trebr_0842 ENOG4108JPM phospho-2-dehydro-3-deoxyheptonate aldolase Trebr_0843 ENOG41075H3 AraC family transcriptional regulator Trebr_0845 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) Trebr_0847 ENOG4105BZ8 glutamate synthase Trebr_0848 ENOG4105HP8 regulator of competence-specific genes Trebr_0852 ENOG4107SVV electron transport complex, RnfABCDGE type, B subunit Trebr_0853 ENOG4105DGN Electron transport complex Trebr_0854 ENOG4105DZB Electron transport complex Trebr_0856 ENOG4105D6A Electron transport complex Trebr_0857 ENOG4107QTR Required for nitrogen fixation. May be part of a membrane complex functioning as an intermediate in the electron transport to nitrogenase (By similarity) Trebr_0860 ENOG4105BZU Histidine kinase Trebr_0861 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase Trebr_0862 ENOG4105C8Q Methyl-accepting chemotaxis Trebr_0865 ENOG4107QKZ Ompa motb domain protein Trebr_0866 ENOG41068JE domain protein Trebr_0870 ENOG4105VCQ rubredoxin Trebr_0871 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) Trebr_0872 ENOG4105C19 ABC transporter Trebr_0873 ENOG4107KET secretion protein, HlyD family Trebr_0875 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) Trebr_0878 ENOG4108IUZ ABC transporter Trebr_0879 ENOG4105W3S hemerythrin-like, metal-binding protein Trebr_0881 ENOG4105DNX Dna topoisomerase iv (Subunit b) Trebr_0882 ENOG4105DF5 DNA topoisomerase IV, subunit A Trebr_0884 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein Trebr_0886 ENOG4105C5S asparaginyl-tRNA synthetase Trebr_0888 ENOG4108R96 Methyltransferase, YaeB family Trebr_0894 ENOG4106TD9 Diguanylate cyclase Trebr_0897 ENOG4107XII Glycosyl Hydrolase Family 88 Trebr_0898 ENOG4105C75 arginyL-tRNA synthetase Trebr_0900 ENOG4105EC8 Methyl-accepting chemotaxis Trebr_0902 ENOG4105K5M 30s ribosomal protein S16 Trebr_0903 ENOG4105VB6 UPF0109 protein Trebr_0904 ENOG41082N4 An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity) Trebr_0905 ENOG4105D6X Specifically methylates guanosine-37 in various tRNAs (By similarity) Trebr_0906 ENOG4108YY1 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity) Trebr_0910 ENOG41082I4 UPF0102 protein Trebr_0918 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) Trebr_0919 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase Trebr_0924 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) Trebr_0928 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) Trebr_0931 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) Trebr_0934 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase Trebr_0935 ENOG41082MQ UPF0178 protein Trebr_0936 ENOG4106BMT Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division (By similarity) Trebr_0937 ENOG4106BH8 Trebr_0938 ENOG4108YZX Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity) Trebr_0939 ENOG41084MZ 50S ribosomal protein L35 Trebr_0940 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) Trebr_0942 ENOG4105D2N Aldolase Trebr_0946 ENOG4107YM1 mraZ protein Trebr_0947 ENOG4105CGJ Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) Trebr_0949 ENOG4107EES Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity) Trebr_0950 ENOG4105CNI cell division protein FtsW Trebr_0951 ENOG4105K7E Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly (By similarity) Trebr_0952 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) Trebr_0953 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) Trebr_0954 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) Trebr_0956 ENOG4105C79 DNA protecting protein DprA Trebr_0957 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) Trebr_0958 ENOG4108I7H Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) Trebr_0959 ENOG4108R5P Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery (By similarity) Trebr_0960 ENOG4105C4N this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis (By similarity) Trebr_0961 ENOG4105Q75 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) Trebr_0962 ENOG4108ZC9 flagellar basal-body rod protein flgc Trebr_0963 ENOG41069WH flagellar hook-basal body complex Trebr_0964 ENOG4107U2N Flagellar M-ring protein Trebr_0965 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) Trebr_0966 ENOG4105W2B Flagellar assembly protein Trebr_0967 ENOG4108JIR Flagellum-specific ATP synthase Trebr_0969 ENOG4105C22 threonyL-tRNA synthetase Trebr_0971 ENOG4105D8I Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS (By similarity) Trebr_0972 ENOG4108IQE Amp-dependent synthetase and ligase Trebr_0977 ENOG41076UM multiple antibiotic resistance (MarC)-related protein Trebr_0979 ENOG4105EAB amino acid AbC transporter Trebr_0980 ENOG4105E5Q amino acid AbC transporter Trebr_0981 ENOG4105CDA abc transporter atp-binding protein Trebr_0983 ENOG4105CTJ Metal Dependent Phosphohydrolase Trebr_0984 ENOG41082QW Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) Trebr_0985 ENOG4105C37 (CBS) domain Trebr_0991 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) Trebr_0993 ENOG4105D60 lipoprotein releasing system transmembrane protein Trebr_0994 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) Trebr_0997 ENOG41066A3 ATP guanido phosphotransferase Trebr_0998 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit Trebr_1003 ENOG4105EB3 Histidine kinase Trebr_1007 ENOG4105D5G Transposase Trebr_1010 ENOG4105EWC Purine nucleoside phosphorylase Trebr_1011 ENOG4108KB1 transcriptional regulator, arac family Trebr_1013 ENOG4107RVV histidinol phosphate phosphatase, hisj family Trebr_1024 ENOG4105D8K carboxyl transferase Trebr_1028 ENOG4105EPW hflc protein Trebr_1029 ENOG4107RIZ hflk protein Trebr_1030 ENOG4105U5Y Transcriptional regulator Trebr_1034 ENOG4107TXC Transcriptional regulator Trebr_1039 ENOG4105CIR epoxide hydrolase Trebr_1040 ENOG4108MTT Glutamate-rich protein grpB Trebr_1044 ENOG4108V4B ThiJ pfpI Trebr_1045 ENOG4105D29 Helix-turn-helix type 11 domain protein Trebr_1047 ENOG4105E4P ATPase (AAA Trebr_1048 ENOG4108D32 Methyltransferase Trebr_1049 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase Trebr_1054 ENOG4105CK7 Sodium proline symporter Trebr_1055 ENOG4108Y51 tRNA-binding protein Trebr_1058 ENOG4105EFU Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin (By similarity) Trebr_1069 ENOG4105D5G Transposase Trebr_1074 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) Trebr_1075 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) Trebr_1077 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) Trebr_1078 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase Trebr_1079 ENOG4105C5V Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity) Trebr_1080 ENOG4105CAS nag kinase Trebr_1081 ENOG4105C8Y Acetylornithine aminotransferase Trebr_1083 ENOG4105EMA Periplasmic binding protein LacI transcriptional regulator Trebr_1084 ENOG4105C2J ABC transporter Trebr_1085 ENOG4107R2W ABC transporter, permease Trebr_1086 ENOG4108UHU Aldolase Trebr_1087 ENOG4105YVS arsR family transcriptional regulator Trebr_1088 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) Trebr_1089 ENOG4106DBE Involved in DNA repair and RecF pathway recombination (By similarity) Trebr_1090 ENOG4105DR4 Methyltransferase Trebr_1091 ENOG4105DKX Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) Trebr_1094 ENOG4105F8V Hydrolase, tatD family Trebr_1096 ENOG4105C3F Signal peptidase i Trebr_1098 ENOG4105FAV ABC, transporter Trebr_1101 ENOG4107I15 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) Trebr_1102 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) Trebr_1103 ENOG4105CHT Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) Trebr_1107 ENOG4105BZU Histidine kinase Trebr_1108 ENOG4105C8Q Methyl-accepting chemotaxis Trebr_1112 ENOG4107RJF diphosphate--fructose-6-phosphate 1-phosphotransferase (EC 2.7.1.90) Trebr_1113 ENOG4105KRS Proteinase inhibitor Trebr_1115 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) Trebr_1117 ENOG4108H5C Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity) Trebr_1124 ENOG4105EPI acetyltransferase, (GNAT) family Trebr_1130 ENOG4105D5G Transposase Trebr_1136 ENOG4105MB2 Trebr_1138 ENOG4105VS8 Flagellar biosynthetic protein fliq Trebr_1139 ENOG4105D19 Role in flagellar biosynthesis (By similarity) Trebr_1140 ENOG4105D00 flagellar biosynthetic protein flhB Trebr_1141 ENOG4105D7B Flagellar biosynthesis protein flha Trebr_1142 ENOG4105FZW flagellar biosynthesis regulator FlhF Trebr_1145 ENOG4105DN4 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) Trebr_1151 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) Trebr_1154 ENOG4105BZU Histidine kinase Trebr_1155 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family Trebr_1156 ENOG410834F Transcriptional regulator Trebr_1159 ENOG4105DCI Phosphohydrolase Trebr_1160 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) Trebr_1161 ENOG41068UM RNA Polymerase Trebr_1162 ENOG4105DKX Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) Trebr_1163 ENOG4105C2V Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) Trebr_1164 ENOG4105EEI dihydropteroate synthase Trebr_1165 ENOG4105C8B TIGR00159 family Trebr_1167 ENOG41083V3 Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity) Trebr_1168 ENOG4108CER Uncharacterized protein conserved in bacteria (DUF2225) Trebr_1169 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) Trebr_1170 ENOG4105C25 Primosomal protein n' Trebr_1171 ENOG4108UN4 phage SPO1 DNA polymerase-related protein Trebr_1174 ENOG4105MAX Superoxide reductase Trebr_1175 ENOG4105DSF transport protein Trebr_1176 ENOG4105CGR Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) Trebr_1177 ENOG4105MPN Membrane Trebr_1178 ENOG4105C8Q Methyl-accepting chemotaxis Trebr_1179 ENOG4105DFU Cell wall formation (By similarity) Trebr_1182 ENOG4105ENN converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity) Trebr_1183 ENOG4108RY1 ATP synthase, subunit E Trebr_1185 ENOG4107RVI Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit (By similarity) Trebr_1186 ENOG4107RQX Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit Trebr_1187 ENOG4108WBK V-type ATP synthase subunit D Trebr_1188 ENOG4107U1W v-type ATP synthase subunit I Trebr_1190 ENOG4105C4E Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) Trebr_1193 ENOG4105D3Q Sugar transferase Trebr_1197 ENOG4108Z11 Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity) Trebr_1199 ENOG4108JJB ABC transporter Trebr_1200 ENOG4105VKD bioY protein Trebr_1201 ENOG4107R05 Transfers the fatty acyl group on membrane lipoproteins (By similarity) Trebr_1202 ENOG41080VC Galactokinase (EC 2.7.1.6) Trebr_1203 ENOG4105CV2 Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates (By similarity) Trebr_1206 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) Trebr_1208 ENOG41090Q2 Trebr_1210 ENOG4107W7Y Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) Trebr_1211 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) Trebr_1213 ENOG4105DR5 peptidase Trebr_1220 ENOG4108Z29 Flavodoxin Trebr_1222 ENOG4105DSM The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex, which has 2 components the iron protein and the molybdenum-iron protein (By similarity) Trebr_1225 ENOG4105S10 periplasmic binding protein Trebr_1226 ENOG4105EHG Permease protein Trebr_1227 ENOG4105E0A ABC, transporter Trebr_1228 ENOG4105EQD regulatoR Trebr_1229 ENOG4105C2F Histidine kinase Trebr_1231 ENOG4105C2J ABC transporter Trebr_1232 ENOG4105CNN ABC, transporter Trebr_1236 ENOG4105C3M thioredoxin reductase Trebr_1240 ENOG41064MX Tetr family transcriptional regulator Trebr_1243 ENOG4107QYE Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) Trebr_1244 ENOG4105SYT Methylenetetrahydrofolate reductase Trebr_1247 ENOG4105DSE periplasmic solute binding protein Trebr_1249 ENOG4105CC5 ABC transporter Trebr_1252 ENOG4108Z1K This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) Trebr_1255 ENOG4105C6U Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity) Trebr_1257 ENOG4105YFD chemotaxis, protein Trebr_1259 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) Trebr_1260 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) Trebr_1262 ENOG4107TFB basic membrane Trebr_1263 ENOG4108JQ9 ABC transporter Trebr_1264 ENOG4105UIB (ABC) transporter Trebr_1268 ENOG4105FQP Beta-lactamase Trebr_1275 ENOG4105UQX Mate efflux family protein Trebr_1276 ENOG4105E2R ROK family Trebr_1277 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein Trebr_1278 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) Trebr_1279 ENOG4105CDH Citrulline--aspartate ligase Trebr_1281 ENOG4108JPM phospho-2-dehydro-3-deoxyheptonate aldolase Trebr_1283 ENOG4105D8G Major Facilitator superfamily Trebr_1284 ENOG4108UQV Membrane Trebr_1286 ENOG4105C1J atp-dependent rna helicase Trebr_1287 ENOG4105C5H ABC transporter Trebr_1288 ENOG4105C8Q Methyl-accepting chemotaxis Trebr_1290 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) Trebr_1291 ENOG4108IUW ABC transporter Trebr_1299 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) Trebr_1300 ENOG4105DFA alanine racemase domain protein Trebr_1304 ENOG4107QKW extracellular solute-binding protein family 1 Trebr_1305 ENOG4107RCV ABC transporter, permease Trebr_1306 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) Trebr_1307 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase Trebr_1308 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving Trebr_1312 ENOG4105M6F mutator MutT protein Trebr_1315 ENOG4105GVR general secretion pathway protein D Trebr_1316 ENOG4107QHF type ii secretion system protein e Trebr_1317 ENOG4105D7Q type ii secretion system Trebr_1330 ENOG4105D5G Transposase Trebr_1335 ENOG4105D5G Transposase Trebr_1341 ENOG4105CUT histidyl-tRNA synthetase Trebr_1342 ENOG4105CGM Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis (By similarity) Trebr_1343 ENOG4105C7N Xanthine uracil vitamin C permease Trebr_1345 ENOG4105D98 threonine synthase Trebr_1347 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) Trebr_1353 ENOG4108JA2 transcriptioN-repair coupling factor Trebr_1354 ENOG4105EJU HAD-superfamily hydrolase subfamily IA variant 3 Trebr_1355 ENOG4105CNI cell division protein FtsW Trebr_1356 ENOG4105CJN penicillin-binding protein Trebr_1359 ENOG4105DFF Rod shape-determining protein mreb Trebr_1362 ENOG4107QVY Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) Trebr_1363 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) Trebr_1366 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) Trebr_1368 ENOG4105CXW Synthesizes alpha-1,4-glucan chains using ADP-glucose (By similarity) Trebr_1373 ENOG4105D4J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate Trebr_1374 ENOG4105C31 Tryptophanyl-tRNA synthetase Trebr_1376 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) Trebr_1388 ENOG4105DJ0 Poly(A) Polymerase Trebr_1390 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) Trebr_1391 ENOG4105ZFX Trebr_1393 ENOG4105C55 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs Trebr_1395 ENOG4105C5I Dehydrogenase Trebr_1397 ENOG4105MQS Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) Trebr_1398 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) Trebr_1399 ENOG4105E0X reductase Trebr_1400 ENOG41067QW Transcriptional regulator Trebr_1401 ENOG4108HRN Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) Trebr_1403 ENOG4105CQ7 ATP-dependent helicase Trebr_1404 ENOG4107ZYR domain protein Trebr_1407 ENOG4105C3F Signal peptidase i Trebr_1408 ENOG4105CHR reductase Trebr_1413 ENOG4108ZBM Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity) Trebr_1414 ENOG41084E5 Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) Trebr_1415 ENOG41085YX 50S ribosomal protein L32 Trebr_1416 ENOG4108ZEF Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity) Trebr_1418 ENOG4105SXG Trebr_1419 ENOG4108Z03 MAF-like protein Trebr_1420 ENOG4105CE9 30S ribosomal protein S2 Trebr_1421 ENOG4105CU7 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity) Trebr_1422 ENOG4108VCV Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity) Trebr_1423 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) Trebr_1425 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) Trebr_1426 ENOG4105DZP Membrane-associated zinc metalloprotease Trebr_1428 ENOG4105CDU Replicative dna helicase Trebr_1429 ENOG4105K9Q Binds to the 23S rRNA (By similarity) Trebr_1430 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) Trebr_1431 ENOG4105Z8H single-stranded DNA-binding protein Trebr_1432 ENOG41084AY Binds together with S18 to 16S ribosomal RNA (By similarity) Trebr_1433 ENOG4105C8T Leucyl-tRNA synthetase Trebr_1442 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) Trebr_1444 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) Trebr_1449 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) Trebr_1451 ENOG4105BZ1 (ABC) transporter Trebr_1452 ENOG4105BZ1 (ABC) transporter Trebr_1454 ENOG41084YP 30S ribosomal protein S21 Trebr_1456 ENOG4105G3C Type iv pilus assembly Trebr_1460 ENOG4105IJJ transcriptional regulator, crp fnr family Trebr_1461 ENOG4107QWW Cell wall formation (By similarity) Trebr_1462 ENOG4105C8N cysteinyl-tRNA synthetase Trebr_1463 ENOG4105DN4 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) Trebr_1466 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) Trebr_1468 ENOG4105W5Q DNA repair protein (RadC Trebr_1470 ENOG4105CPC Aldo Keto reductase Trebr_1471 ENOG4105D6S protein involved in catabolism of external DNA Trebr_1472 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit Trebr_1476 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) Trebr_1479 ENOG4105KA4 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity) Trebr_1480 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) Trebr_1481 ENOG4105E2N Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity) Trebr_1482 ENOG4105KY8 Rubrerythrin Trebr_1483 ENOG41090R7 Ferric uptake Trebr_1487 ENOG4105F8V Hydrolase, tatD family Trebr_1488 ENOG4105C8Q Methyl-accepting chemotaxis Trebr_1490 ENOG4105F8J Adenylate Guanylate cyclase Trebr_1491 ENOG4105CBS Chea signal transduction histidine kinase Trebr_1492 ENOG4105BZU Histidine kinase Trebr_1493 ENOG4105CMP catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity) Trebr_1496 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) Trebr_1497 ENOG4105CFG Acts as a chaperone (By similarity) Trebr_1498 ENOG4105K90 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ Trebr_1500 ENOG4105CU9 asparagine synthetase A Trebr_1504 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) Trebr_1510 ENOG4105RJI Trebr_1511 ENOG4105CXW Synthesizes alpha-1,4-glucan chains using ADP-glucose (By similarity) Trebr_1512 ENOG4105CHM Aminotransferase Trebr_1514 ENOG4105CJT Mannose-1-phosphate guanylyltransferase Trebr_1516 ENOG4108UH4 Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity) Trebr_1518 ENOG4107UIY sua5 ycio yrdc ywlc family protein Trebr_1520 ENOG410698I Trebr_1522 ENOG4105X4X Protein of unknown function DUF115 Trebr_1523 ENOG41090QV Protein of unknown function DUF115 Trebr_1526 ENOG4107V28 uracil phosphoribosyltransferase Trebr_1528 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) Trebr_1530 ENOG4108Z4J Cytidine monophosphate kinase Trebr_1531 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) Trebr_1534 ENOG4105IDI abc transporter atp-binding protein Trebr_1535 ENOG4105NHU Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group (By similarity) Trebr_1536 ENOG4105CDY transcriptional regulatory protein Trebr_1537 ENOG4105DBV ornithine carbamoyltransferase Trebr_1539 ENOG4105DC7 peptidase M24 Trebr_1542 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) Trebr_1543 ENOG4107RFD Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) Trebr_1546 ENOG41083S7 flagellar protein FlaG Trebr_1550 ENOG4105K8N protein family UPF0079, ATPase Trebr_1551 ENOG41072GX Peptidase M22 Glycoprotease Trebr_1552 ENOG4106AM8 polysaccharide lyase family 8 Trebr_1556 ENOG4106AM8 polysaccharide lyase family 8 Trebr_1558 ENOG4105C50 Binding-protein-dependent transport systems, inner membrane component Trebr_1560 ENOG4105UEI Transcriptional Regulator AraC Family Trebr_1562 ENOG4105CHR reductase Trebr_1563 ENOG4108IYU L-aspartate oxidase Trebr_1569 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) Trebr_1572 ENOG4105DUM transcriptional regulator, lysR family Trebr_1576 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation Trebr_1577 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) Trebr_1578 ENOG4105CHN ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) Trebr_1582 ENOG4105D86 that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity) Trebr_1584 ENOG4105E1Z Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane Trebr_1586 ENOG410805Y Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) Trebr_1588 ENOG4105D49 3-dehydroquinate synthase Trebr_1589 ENOG4105C3J Cysteine desulfurase Trebr_1593 ENOG4108JDX DNA polymerase iii, epsilon subunit Trebr_1595 ENOG41068JE domain protein Trebr_1597 ENOG4105CN7 Flagellar biosynthetic protein FliP Trebr_1599 ENOG4105DD5 Flagellar motor switch protein Trebr_1600 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) Trebr_1601 ENOG41064SM flagellar basal body-associated protein flil Trebr_1602 ENOG4107XSU flagellar motor protein motb Trebr_1603 ENOG4107R0U MotA TolQ exbB proton channel Trebr_1605 ENOG4105BZE flagellar hook protein, FlgE Trebr_1606 ENOG410822I Flagellar hook capping protein Trebr_1608 ENOG4105FF6 Modulates transcription in response to changes in cellular NADH NAD( ) redox state (By similarity) Trebr_1609 ENOG4105DR4 Methyltransferase Trebr_1612 ENOG4108UH2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) Trebr_1616 ENOG4108UK1 Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant (By similarity) Trebr_1619 ENOG4105BZU Histidine kinase Trebr_1620 ENOG4105XJC Two component transcriptional regulator (Winged helix family Trebr_1623 ENOG4105DDQ anthranilate synthase Trebr_1624 ENOG4105DK0 Indole-3-glycerol phosphate synthase Trebr_1625 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) Trebr_1626 ENOG4105F6H The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity) Trebr_1627 ENOG4105E2D ec 3.2.1.52 Trebr_1630 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) Trebr_1632 ENOG4105D3Q Sugar transferase Trebr_1636 ENOG4108YZG isomerase Trebr_1638 ENOG4105CIH Imidazole acetol-phosphate transaminase Trebr_1642 ENOG4108Z4R 3-deoxy-d-manno-octulosonate 8-phosphate phosphatase Trebr_1650 ENOG4107SBE Glycosyl transferase (Group 1 Trebr_1651 ENOG4107QRS glycosyltransferase group 2 family protein Trebr_1661 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) Trebr_1662 ENOG4105C98 muts2 protein Trebr_1663 ENOG4105DM4 PTS System Trebr_1664 ENOG4105KG3 cytidine deaminase Trebr_1667 ENOG4107XTC May be involved in the formation or repair of Fe-S clusters present in iron-sulfur proteins Trebr_1668 ENOG4105C3J Cysteine desulfurase Trebr_1669 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) Trebr_1671 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family Trebr_1672 ENOG4105PNM synthesis protein Trebr_1675 ENOG4105ENE Histidine kinase Trebr_1676 ENOG4105WH1 Two component transcriptional regulator luxr family Trebr_1681 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) Trebr_1683 ENOG4105DP9 ABC transporter Trebr_1686 ENOG4105D9Q decarboxylase (Beta subunit) Trebr_1687 ENOG4107QSA Oxaloacetate decarboxylase Trebr_1689 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) Trebr_1690 ENOG4105CFH Aspartokinase Trebr_1691 ENOG4105C0H protease Trebr_1692 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) Trebr_1693 ENOG4105DVC DnaJ domain protein Trebr_1696 ENOG4106C6A Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) Trebr_1697 ENOG4108JIP Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit (By similarity) Trebr_1698 ENOG4107RVI Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit (By similarity) Trebr_1702 ENOG4107WUB V-type ATPase 116 kDa subunit Trebr_1705 ENOG4107RM2 PTS IIA-like nitrogen-regulatory protein PtsN Trebr_1706 ENOG4106447 Preprotein translocase subunit SecG Trebr_1707 ENOG4105CP7 Triose-phosphate isomerase Trebr_1709 ENOG4105BZU Histidine kinase Trebr_1711 ENOG4105J4Q Transcriptional regulator Trebr_1713 ENOG4105EI2 Pseudouridine synthase Trebr_1715 ENOG4105VFU Rna-binding protein Trebr_1716 ENOG4105F4C Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress (By similarity) Trebr_1719 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family Trebr_1720 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) Trebr_1721 ENOG4105CAT Cytidine monophosphate kinase Trebr_1722 ENOG4105FE9 pseudouridine synthase Trebr_1723 ENOG4105K8I Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity) Trebr_1724 ENOG4108KVX Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves (By similarity) Trebr_1726 ENOG4105C68 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity) Trebr_1730 ENOG4105DJV ribulose-phosphate 3-epimerase Trebr_1733 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) Trebr_1734 ENOG4108JQC penicillin-binding protein 1A Trebr_1735 ENOG4105FA0 parb-like partition protein Trebr_1739 ENOG4106NKH Trebr_1743 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) Trebr_1746 ENOG4108IJ2 phosphate acetyltransferase Trebr_1750 ENOG4105DR5 peptidase Trebr_1755 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase Trebr_1760 ENOG4107QQ4 Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity) Trebr_1762 ENOG4105UQX Mate efflux family protein Trebr_1765 ENOG4105C4S Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) Trebr_1766 ENOG4105C0H protease Trebr_1769 ENOG4107THF Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) Trebr_1770 ENOG4107TVT This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity) Trebr_1772 ENOG4107SJN Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity) Trebr_1776 ENOG4108WF2 Metal Dependent Phosphohydrolase Trebr_1777 ENOG4107X4V Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) Trebr_1778 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control Trebr_1779 ENOG4105K46 50S ribosomal protein l27 Trebr_1781 ENOG4105KK9 This protein binds to 23S rRNA in the presence of protein L20 (By similarity) Trebr_1789 ENOG4105BZ1 (ABC) transporter Trebr_1790 ENOG4105BZ1 (ABC) transporter Trebr_1791 ENOG4105D29 Helix-turn-helix type 11 domain protein Trebr_1794 ENOG4105C8Q Methyl-accepting chemotaxis Trebr_1801 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase Trebr_1804 ENOG4105D5G Transposase Trebr_1807 ENOG4108TMJ glycosyl transferase Trebr_1810 ENOG4105CG5 Glycosyl transferase (Group 1 Trebr_1814 ENOG4105XBY Regulates arginine biosynthesis genes (By similarity) Trebr_1819 ENOG4107QP8 phosphohexose isomerase Trebr_1824 ENOG4105EYH Exonuclease Trebr_1826 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) Trebr_1827 ENOG4105D3G Pseudouridine synthase Trebr_1828 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) Trebr_1832 ENOG4105DVT helicase Trebr_1834 ENOG4107NGC Flagellar filament outer layer protein Trebr_1836 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase Trebr_1837 ENOG4105C12 Phosphoribosylglycinamide synthetase Trebr_1838 ENOG4105CET Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria (By similarity) Trebr_1841 ENOG4105CG3 alpha amylase, catalytic region Trebr_1843 ENOG41067QG Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) Trebr_1844 ENOG4105DC6 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity) Trebr_1851 ENOG4105WN5 stage II sporulation protein Trebr_1853 ENOG4105VM8 Could accelerate the degradation of some genes transcripts potentially through selective RNA binding (By similarity) Trebr_1854 ENOG4105W5T Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum (By similarity) Trebr_1855 ENOG4105DTJ flagellar hook-associated protein Trebr_1858 ENOG4105C59 p-type ATPase Trebr_1859 ENOG4105VPX protein, conserved in bacteria Trebr_1861 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase Trebr_1862 ENOG4108MGY Histidine kinase Trebr_1866 ENOG4106XHX Trebr_1872 ENOG4107QRS glycosyltransferase group 2 family protein Trebr_1875 ENOG4106WTF Glycosyl transferase, family 2 Trebr_1880 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) Trebr_1881 ENOG4105CPF Cell wall formation (By similarity) Trebr_1882 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) Trebr_1884 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis Trebr_1885 ENOG4105CGA flagellar basal-body rod protein FlgG Trebr_1886 ENOG4105CGA flagellar basal-body rod protein FlgG Trebr_1888 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) Trebr_1889 ENOG4105DG6 mannose-6-phosphate isomerase Trebr_1892 ENOG4105D3A purine nucleoside phosphorylase DeoD-type Trebr_1896 ENOG4105CAH Chromate Trebr_1897 ENOG4107QJQ Mate efflux family protein Trebr_1898 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase Trebr_1899 ENOG4105ECA phosphoserine phosphatase homoserine phosphotransferase bifunctional protein Trebr_1900 ENOG4105E2Y ABC, transporter Trebr_1903 ENOG4105JKW Valine--pyruvate aminotransferase Trebr_1905 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase Trebr_1906 ENOG4107RI4 Transfers the fatty acyl group on membrane lipoproteins (By similarity) Trebr_1908 ENOG41086BH Binds directly to 16S ribosomal RNA (By similarity) Trebr_1909 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B Trebr_1911 ENOG4107QPA Cleaves GlcNAc linked beta-1,4 to MurNAc tripeptides (By similarity) Trebr_1912 ENOG4105CG6 trap dicarboxylate transporter dctm subunit Trebr_1913 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit Trebr_1915 ENOG4105HY2 Glycosidase related protein Trebr_1916 ENOG4105DFY n-acylglucosamine 2-epimerase Trebr_1917 ENOG4105CKB glycosidase Trebr_1926 ENOG4105FKQ transcriptional regulator Trebr_1928 ENOG4105CJI Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) Trebr_1932 ENOG4105CT7 inner membrane cred family protein Trebr_1933 ENOG4105HFZ Membrane Trebr_1936 ENOG4105CJN penicillin-binding protein Trebr_1938 ENOG4105DR5 peptidase Trebr_1941 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase Trebr_1945 ENOG4108VJ1 Transcriptional regulator (CarD family Trebr_1946 ENOG4108UH8 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity) Trebr_1950 ENOG4109015 Biopolymer transport protein exbD tolR Trebr_1959 ENOG4105CJR Integral membrane protein (MviN Trebr_1960 ENOG4105DC7 peptidase M24 Trebr_1963 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) Trebr_1964 ENOG4105C1V Peptidase, M16 Trebr_1965 ENOG4105C62 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) Trebr_1966 ENOG4105K77 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity) Trebr_1968 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) Trebr_1969 ENOG41080JB Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity) Trebr_1970 ENOG4107QHU One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) Trebr_1971 ENOG4105CHV Transcription elongation factor NusA Trebr_1972 ENOG410854D Required for maturation of 30S ribosomal subunits (By similarity) Trebr_1978 ENOG4105D5G Transposase Trebr_1986 ENOG4105DZS Phenylacetate-CoA ligase Trebr_1990 ENOG4105D3A purine nucleoside phosphorylase DeoD-type Trebr_1991 ENOG4108Z66 YbaK ebsC protein Trebr_2000 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) Trebr_2011 ENOG4105CHH sulfate transporter Trebr_2015 ENOG4107YAU phenylacetic acid degradation protein Trebr_2017 ENOG4105DRW binding-protein-dependent transport systems inner membrane Component Trebr_2018 ENOG4105S9S Binding-protein-dependent transport systems, inner membrane component Trebr_2022 ENOG4105CKA Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity) Trebr_2023 ENOG4105CE4 GlcNAc 6-P deacetylase Trebr_2024 ENOG4105E2V Glycosyltransferase 36 Trebr_2028 ENOG4108IYU L-aspartate oxidase Trebr_2030 ENOG4107SHJ sulfite reductase subunit b Trebr_2034 ENOG4105CVN desaturase Trebr_2037 ENOG4105C9Q fumarate hydratase class II Trebr_2038 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) Trebr_2040 ENOG41082BM Transcriptional regulator, arsr family Trebr_2044 ENOG4105C8Q Methyl-accepting chemotaxis Trebr_2045 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) Trebr_2061 ENOG4105KME endoribonuclease L-psp Trebr_2062 ENOG4108TFM Kinase, PfkB family Trebr_2063 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) Trebr_2065 ENOG4105CNN ABC, transporter Trebr_2066 ENOG4105C2J ABC transporter Trebr_2067 ENOG4105DFY n-acylglucosamine 2-epimerase Trebr_2069 ENOG4105C59 p-type ATPase Trebr_2072 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) Trebr_2075 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) Trebr_2076 ENOG4105C2M dna polymerase I Trebr_2083 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) Trebr_2087 ENOG4105BZU Histidine kinase Trebr_2090 ENOG4105K9U however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) Trebr_2091 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) Trebr_2098 ENOG4105C7R Atpase associated with various cellular activities aaa_3 Trebr_2102 ENOG4105C0M Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle (By similarity) Trebr_2105 ENOG41082DI 50s ribosomal protein l31 Trebr_2106 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) Trebr_2109 ENOG4105EZ6 Catalyzes the 2'-O-methylation at nucleotide C2498 in 23S rRNA (By similarity) Trebr_2110 ENOG4105CVG Homoserine O-transsuccinylase Trebr_2112 ENOG4105CFP Peptidase U32 Trebr_2113 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) Trebr_2114 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) Trebr_2115 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) Trebr_2117 ENOG4105CCI Myosin-Cross-Reactive Antigen Trebr_2122 ENOG41081GK CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyl-transferase Trebr_2125 ENOG4108YZ4 nudix hydrolase Trebr_2128 ENOG4105VEM Conserved domain protein Trebr_2130 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) Trebr_2131 ENOG4105KZ7 phosphocarrier protein hpr Trebr_2134 ENOG4105C34 Pseudouridine synthase Trebr_2135 ENOG4108JU6 CBS domain protein Trebr_2136 ENOG4108JU6 CBS domain protein Trebr_2138 ENOG4108JIU phosphoribosylformylglycinamidine synthase ii Trebr_2139 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) Trebr_2142 ENOG4108ZB6 transcriptional regulator AsnC family Trebr_2143 ENOG4105CHM Aminotransferase Trebr_2145 ENOG4108JJB ABC transporter Trebr_2147 ENOG4105FEU K -dependent Na -Ca exchanger Trebr_2149 ENOG410624X efflux transporter, rnd family, mfp subunit Trebr_2150 ENOG4105C19 ABC transporter Trebr_2151 ENOG4107RBB ABC transporter, permease Trebr_2152 ENOG4105RKW reductase (By Trebr_2153 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) Trebr_2154 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) Trebr_2155 ENOG4105K63 Thioredoxin Trebr_2160 ENOG4105DZ0 fad dependent oxidoreductase Trebr_2161 ENOG4107QI1 Mate efflux family protein Trebr_2164 ENOG4108ERU trap dicarboxylate transporter subunit DctP Trebr_2166 ENOG4105CG6 trap dicarboxylate transporter dctm subunit Trebr_2169 ENOG4105CJ1 ABC, transporter Trebr_2174 ENOG4105DYN CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. May be involved in the integration of spacer DNA into the CRISPR cassette (By similarity) Trebr_2187 ENOG4105II7 pyrroline-5-carboxylate reductase Trebr_2188 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) Trebr_2191 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) Trebr_2192 ENOG4105CAE Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) Trebr_2194 ENOG4107S6Z Na H antiporter Trebr_2195 ENOG4105C8Q Methyl-accepting chemotaxis Trebr_2196 ENOG4107YNV 3-dehydroquinate dehydratase Trebr_2197 ENOG4105E66 phosphoriboisomerase A Trebr_2199 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) Trebr_2202 ENOG4105CK7 Sodium proline symporter Trebr_2203 ENOG4105BZU Histidine kinase Trebr_2206 ENOG4105C3M thioredoxin reductase Trebr_2212 ENOG4107S21 permease Trebr_2214 ENOG4107SKW Inherit from COG: Alpha beta hydrolase Trebr_2216 ENOG4107QM1 Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity) Trebr_2220 ENOG4105DM4 PTS System Trebr_2225 ENOG4105C30 Nad-dependent epimerase dehydratase Trebr_2227 ENOG4105DMT epimerase dehydratase Trebr_2233 ENOG4105D5G Transposase Trebr_2238 ENOG4107S1W 4-alpha-glucanotransferase Trebr_2240 ENOG4105D98 threonine synthase Trebr_2244 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) Trebr_2249 ENOG4105CYX Short-chain dehydrogenase reductase Sdr Trebr_2250 ENOG4106FVC RNA methyltransferase Trebr_2253 ENOG4105QF0 Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) Trebr_2254 ENOG4105CN1 protease Trebr_2257 ENOG4107WGG Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity) Trebr_2258 ENOG4105CV1 Transketolase (EC 2.2.1.1) Trebr_2259 ENOG4105DTZ bifunctional PTS system fructose-specific transporter subunit IIA HPr protein Trebr_2262 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) Trebr_2263 ENOG4108IV0 ABC, transporter Trebr_2264 ENOG4105C0Z ABC transporter Trebr_2265 ENOG4105CF8 branched-chain amino acid ABC transporter, permease Trebr_2266 ENOG4105C32 Amino acid ABC transporter (Permease) Trebr_2267 ENOG4105CP9 extracellular ligand-binding receptor Trebr_2269 ENOG4108ZT0 50S ribosomal protein l17 Trebr_2270 ENOG4105CTF DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) Trebr_2271 ENOG4105G6W One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) Trebr_2272 ENOG4108UHH Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) Trebr_2273 ENOG4108Z04 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits Trebr_2274 ENOG41067V7 50S ribosomal protein L36 Trebr_2275 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) Trebr_2276 ENOG4108UZ0 Binds to the 23S rRNA (By similarity) Trebr_2277 ENOG41084HK 50S ribosomal protein L30 Trebr_2278 ENOG4108RA9 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) Trebr_2279 ENOG4105K4C This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity) Trebr_2280 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) Trebr_2281 ENOG4108UJY One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity) Trebr_2282 ENOG41082QR Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) Trebr_2283 ENOG4105CW6 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits Trebr_2284 ENOG4105KAR One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity) Trebr_2285 ENOG4108UNN Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity) Trebr_2286 ENOG4105K87 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal Trebr_2287 ENOG41086S0 50s ribosomal protein l29 Trebr_2288 ENOG4108R70 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity) Trebr_2289 ENOG4105CKE Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) Trebr_2290 ENOG41082G4 The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity) Trebr_2291 ENOG4105K7S Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity) Trebr_2292 ENOG4105CFD One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity Trebr_2293 ENOG41080UE One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity) Trebr_2294 ENOG4106U5A One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) Trebr_2295 ENOG4105EEE One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) Trebr_2296 ENOG4108Z10 Involved in the binding of tRNA to the ribosomes (By similarity) Trebr_2297 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) Trebr_2298 ENOG4108UHY One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity) Trebr_2299 ENOG4108UKE Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity) Trebr_2300 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) Trebr_2301 ENOG4108IIJ DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) Trebr_2302 ENOG4105KBC Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity) Trebr_2303 ENOG4108VZM 50s ribosomal protein L10 Trebr_2304 ENOG4105C64 Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity) Trebr_2305 ENOG4108UIK This protein binds directly to 23S ribosomal RNA (By similarity) Trebr_2306 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) Trebr_2308 ENOG41084ED 50S ribosomal protein L33 Trebr_2309 ENOG4105D7W serine acetyltransferase Trebr_2315 ENOG4108Z4U Ferredoxin Trebr_2316 ENOG4105CNU cell division protein FtsK Trebr_2319 ENOG4107RV5 Glycosyl hydrolase family 3 N-terminal domain protein Trebr_2321 ENOG4105D3R alkyl hydroperoxide reductase Trebr_2324 ENOG4105CDJ oxidoreductase FAD NAD(P)-binding domain protein Trebr_2325 ENOG4105BZ8 glutamate synthase Trebr_2326 ENOG4108IQE Amp-dependent synthetase and ligase Trebr_2327 ENOG4105CSS phenylalanyl-tRNA synthetase (alpha subunit) Trebr_2333 ENOG4105F8J Adenylate Guanylate cyclase Trebr_2339 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) Trebr_2340 ENOG4105F8V Hydrolase, tatD family Trebr_2341 ENOG4105DR5 peptidase Trebr_2344 ENOG4105MA4 psp1 domain protein Trebr_2347 ENOG4107QI1 Mate efflux family protein Trebr_2349 ENOG4106AXJ AraC family transcriptional regulator Trebr_2352 ENOG4105DRW binding-protein-dependent transport systems inner membrane Component Trebr_2353 ENOG4105CT8 Phosphorylase Trebr_2354 ENOG4105C4X radical SAM domain protein Trebr_2355 ENOG4105CBG Sulfatase Trebr_2356 ENOG4105C88 aminopeptidase Trebr_2359 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) Trebr_2361 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase Trebr_2362 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) Trebr_2364 ENOG4105F4G Membrane Trebr_2365 ENOG4108ENG carbohydrate kinase, YjeF related protein Trebr_2366 ENOG4106762 Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5- dihydroxy-2,3-pentadione (DPD) (By similarity) Trebr_2367 ENOG4105CRD Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity) Trebr_2369 ENOG4105M6F mutator MutT protein Trebr_2370 ENOG4105D95 Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin (By similarity) Trebr_2371 ENOG4105D78 K07001 NTE family protein Trebr_2372 ENOG4105CGB Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system (By similarity) Trebr_2375 ENOG4108TSD Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) Trebr_2379 ENOG41083HS Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity) Trebr_2381 ENOG4105CFG Acts as a chaperone (By similarity) Trebr_2383 ENOG4108T5G Adenylate Trebr_2384 ENOG4105D0M Protease HtpX homolog Trebr_2386 ENOG4107W2M Sodium hydrogen exchanger Trebr_2389 ENOG4105CE4 GlcNAc 6-P deacetylase Trebr_2391 ENOG4105X0R protein from nitrogen regulatory protein P-II Trebr_2399 ENOG41067SE Tetr family transcriptional regulator Trebr_2410 ENOG4105VVB Trebr_2411 ENOG4105C26 Dehydrogenase Trebr_2413 ENOG4105I03 Flagellin Trebr_2414 ENOG4105F3K May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) Trebr_2415 ENOG4107Z6Q Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity) Trebr_2416 ENOG4105C6E dna polymerase iii Trebr_2418 ENOG4105CQ7 ATP-dependent helicase Trebr_2419 ENOG4105C8Q Methyl-accepting chemotaxis Trebr_2420 ENOG4108UT2 hemolysin iii Trebr_2421 ENOG4105C2N RNA methyltransferase TrmH family group 3 Trebr_2422 ENOG4105K5B UPF0225 protein Trebr_2428 ENOG4105D37 Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA (By similarity) Trebr_2430 ENOG4105CJX Molecular chaperone. Has ATPase activity (By similarity) Trebr_2434 ENOG4105CGH 5'-nucleotidase Trebr_2436 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) Trebr_2438 ENOG4106TCE Trebr_2441 ENOG4107QTH restriction modification system DNA specificity domain Trebr_2458 ENOG4105C0D helicase Trebr_2459 ENOG4105CB5 ATP-dependent DNA helicase recG Trebr_2465 ENOG4105CHI Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB (By similarity) Trebr_2469 ENOG4105CKK Glycosyl transferase, family 2 Trebr_2473 ENOG4105WD1 Membrane Trebr_2475 ENOG4105CJ1 ABC, transporter Trebr_2477 ENOG4105JKQ Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity) Trebr_2478 ENOG4105EHG Permease protein Trebr_2479 ENOG4105E0A ABC, transporter Trebr_2482 ENOG4105EQD regulatoR Trebr_2483 ENOG4105C2F Histidine kinase Trebr_2485 ENOG4105C50 Binding-protein-dependent transport systems, inner membrane component Trebr_2488 ENOG4108MYR Secreted protein Trebr_2492 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) Trebr_2495 ENOG410835P This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) Trebr_2496 ENOG4107XF7 NGG1p interacting factor 3 protein, NIF3 Trebr_2498 ENOG4108HU6 Metal dependent phosphohydrolase Trebr_2501 ENOG4105ZAM anti-sigma-28 factor flgm family protein Trebr_2502 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) Trebr_2509 ENOG4108JQB penicillin-binding protein 1C Trebr_2510 ENOG4105DN3 alpha-2-macroglobulin domain protein Trebr_2511 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) Trebr_2514 ENOG4105EJ7 Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O (By similarity) Trebr_2517 ENOG4107QP2 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) Trebr_2519 ENOG4105CTQ phosphohexokinase Trebr_2523 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) Trebr_2527 ENOG4105HS6 binding-protein-dependent transport systems inner membrane Component Trebr_2528 ENOG4105DRS transport system, permease Trebr_2529 ENOG4105EJU HAD-superfamily hydrolase subfamily IA variant 3 Trebr_2531 ENOG4105EQD regulatoR Trebr_2532 ENOG4105C2F Histidine kinase Trebr_2537 ENOG4105DHT Metal Dependent Phosphohydrolase Trebr_2540 ENOG4105CUZ uba thif-type nad fad binding protein Trebr_2547 ENOG4105DUM transcriptional regulator, lysR family Trebr_2560 ENOG4107TIA phenylalanyl-tRNA synthetase (beta subunit) Trebr_2570 ENOG4108EE5 Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) Trebr_2578 ENOG4105ETE Transcriptional regulator (LacI family Trebr_2581 ENOG4105WPN DNA integration recombination invertion protein Trebr_2582 ENOG4105EX2 Binding-protein-dependent transport systems, inner membrane component Trebr_2583 ENOG4105F0P binding-protein-dependent transport systems inner membrane Component Trebr_2585 ENOG4107QZM n-acetylglutamate synthase Trebr_2586 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) Trebr_2587 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) Trebr_R0022 ENOG4108RAC Rubrerythrin