locus-tag	class	description
Trebr_0001	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
Trebr_0002	COG0592	DNA-directed DNA polymerase activity
Trebr_0003	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
Trebr_0006	COG0594	ribonuclease P activity
Trebr_0007	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
Trebr_0008	COG0706	membrane insertase activity
Trebr_0009	COG1847	R3H domain protein
Trebr_0011	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
Trebr_0016	COG2885	chlorophyll binding
Trebr_0017	COG1904	glucuronate isomerase
Trebr_0018	COG2721	sulfolactate sulfo-lyase activity
Trebr_0019	COG0246	Mannitol dehydrogenase
Trebr_0020	COG2207	Transcriptional regulator
Trebr_0020	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
Trebr_0021	COG4209	transmembrane transport
Trebr_0022	COG0395	ABC-type sugar transport system, permease component
Trebr_0023	COG1653	transport
Trebr_0031	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
Trebr_0034	COG0622	Phosphoesterase
Trebr_0035	COG1959	2 iron, 2 sulfur cluster binding
Trebr_0036	COG0076	glutamate decarboxylase activity
Trebr_0042	COG1486	melibiose metabolic process
Trebr_0045	COG0395	ABC-type sugar transport system, permease component
Trebr_0048	COG1350	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
Trebr_0052	COG0235	Class ii aldolase
Trebr_0053	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
Trebr_0058	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
Trebr_0059	COG0384	phenazine biosynthesis protein PhzF
Trebr_0062	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
Trebr_0063	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
Trebr_0065	COG0737	Belongs to the 5'-nucleotidase family
Trebr_0070	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
Trebr_0071	COG1744	ABC transporter substrate-binding protein PnrA-like
Trebr_0072	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
Trebr_0078	COG0454	-acetyltransferase
Trebr_0086	COG2226	methyltransferase
Trebr_0087	COG1131	(ABC) transporter
Trebr_0092	COG1312	Catalyzes the dehydration of D-mannonate
Trebr_0093	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
Trebr_0094	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
Trebr_0095	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
Trebr_0096	COG1063	alcohol dehydrogenase
Trebr_0097	COG1063	alcohol dehydrogenase
Trebr_0098	COG1802	Transcriptional regulator
Trebr_0099	COG1028	Short-chain dehydrogenase reductase Sdr
Trebr_0102	COG0745	RESPONSE REGULATOR receiver
Trebr_0103	COG2201	protein-glutamate methylesterase activity
Trebr_0105	COG0643	Histidine kinase
Trebr_0105	COG2198	Histidine kinase
Trebr_0107	COG0835	chemotaxis
Trebr_0108	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
Trebr_0110	COG0455	bacterial-type flagellum organization
Trebr_0111	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
Trebr_0113	COG0372	Belongs to the citrate synthase family
Trebr_0115	COG4254	PFAM FecR protein
Trebr_0118	COG3250	beta-galactosidase activity
Trebr_0119	COG3250	beta-galactosidase activity
Trebr_0123	COG2197	response regulator
Trebr_0125	COG1454	alcohol dehydrogenase
Trebr_0127	COG1070	Carbohydrate kinase
Trebr_0130	COG4154	Belongs to the RbsD FucU family
Trebr_0131	COG1879	ABC-type sugar transport system periplasmic component
Trebr_0133	COG4211	Belongs to the binding-protein-dependent transport system permease family
Trebr_0135	COG0789	Transcriptional regulator
Trebr_0136	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
Trebr_0140	COG3681	Belongs to the UPF0597 family
Trebr_0143	COG3708	Transcriptional regulator
Trebr_0143	COG2207	Transcriptional regulator
Trebr_0153	COG0534	Mate efflux family protein
Trebr_0157	COG1794	racemase activity, acting on amino acids and derivatives
Trebr_0163	COG5002	protein histidine kinase activity
Trebr_0165	COG0745	RESPONSE REGULATOR receiver
Trebr_0167	COG5002	protein histidine kinase activity
Trebr_0169	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
Trebr_0170	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
Trebr_0171	COG1309	transcriptional regulator
Trebr_0172	COG2193	ferroxidase activity
Trebr_0173	COG0573	inorganic phosphate transmembrane transporter activity
Trebr_0174	COG0581	inorganic phosphate transmembrane transporter activity
Trebr_0180	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
Trebr_0188	COG1175	transmembrane transport
Trebr_0189	COG0395	ABC-type sugar transport system, permease component
Trebr_0191	COG1554	hydrolase, family 65, central catalytic
Trebr_0192	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
Trebr_0194	COG2201	protein-glutamate methylesterase activity
Trebr_0196	COG0004	ammonium transporteR
Trebr_0197	COG0583	DNA-binding transcription factor activity
Trebr_0203	COG0656	L-ascorbic acid biosynthetic process
Trebr_0209	COG0667	Aldo Keto reductase
Trebr_0215	COG1309	transcriptional regulator
Trebr_0221	COG0612	Peptidase, M16
Trebr_0223	COG1132	(ABC) transporter
Trebr_0224	COG0488	(ABC) transporter
Trebr_0227	COG0840	transmembrane signaling receptor activity
Trebr_0230	COG1047	Peptidyl-prolyl cis-trans
Trebr_0233	COG5001	Diguanylate cyclase
Trebr_0235	COG1131	(ABC) transporter
Trebr_0237	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
Trebr_0237	COG1263	PTS System
Trebr_0239	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
Trebr_0240	COG3711	transcriptional antiterminator
Trebr_0241	COG2723	6-phospho-beta-galactosidase activity
Trebr_0247	COG0505	Belongs to the CarA family
Trebr_0248	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
Trebr_0251	COG0039	L-malate dehydrogenase activity
Trebr_0252	COG3706	GGDEF domain
Trebr_0253	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
Trebr_0254	COG0671	phosphoesterase, PA-phosphatase related
Trebr_0256	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
Trebr_0259	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
Trebr_0263	COG1869	D-ribose catabolic process
Trebr_0264	COG1129	ABC transporter
Trebr_0265	COG1172	Belongs to the binding-protein-dependent transport system permease family
Trebr_0266	COG1879	ABC-type sugar transport system periplasmic component
Trebr_0267	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
Trebr_0269	COG1704	LemA family
Trebr_0274	COG0442	prolyl-tRNA aminoacylation
Trebr_0278	COG4032	Thiamine pyrophosphate enzyme, N-terminal TPP binding domain
Trebr_0278	COG0028	Belongs to the TPP enzyme family
Trebr_0282	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
Trebr_0286	COG0562	UDP-galactopyranose mutase
Trebr_0288	COG1216	Glycosyl transferase, family 2
Trebr_0293	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
Trebr_0294	COG0463	Glycosyl transferase, family 2
Trebr_0301	COG0706	membrane insertase activity
Trebr_0306	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
Trebr_0309	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
Trebr_0314	COG1285	pathogenesis
Trebr_0317	COG0561	phosphatase activity
Trebr_0319	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
Trebr_0321	COG4753	response regulator
Trebr_0321	COG2207	Transcriptional regulator
Trebr_0322	COG2972	Histidine kinase
Trebr_0325	COG0395	ABC-type sugar transport system, permease component
Trebr_0327	COG0318	PFAM AMP-dependent synthetase and ligase
Trebr_0328	COG1388	LysM domain
Trebr_0328	COG0791	NLP P60 protein
Trebr_0336	COG2900	Belongs to the SlyX family
Trebr_0337	COG1609	Transcriptional regulator
Trebr_0338	COG1129	ABC transporter
Trebr_0342	COG0745	RESPONSE REGULATOR receiver
Trebr_0343	COG0037	tRNA processing
Trebr_0344	COG1475	DNA binding
Trebr_0345	COG0840	transmembrane signaling receptor activity
Trebr_0346	COG0668	transmembrane transport
Trebr_0347	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
Trebr_0348	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
Trebr_0351	COG0284	orotidine-5'-phosphate decarboxylase activity
Trebr_0352	COG0535	radical SAM domain protein
Trebr_0356	COG2189	Belongs to the N(4) N(6)-methyltransferase family
Trebr_0358	COG4120	Belongs to the binding-protein-dependent transport system permease family
Trebr_0364	COG1061	Type III restriction enzyme res subunit
Trebr_0369	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
Trebr_0370	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
Trebr_0371	COG1088	dTDP-glucose 4,6-dehydratase activity
Trebr_0375	COG1475	DNA binding
Trebr_0376	COG1192	Involved in chromosome partitioning
Trebr_0386	COG0753	catalase activity
Trebr_0387	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
Trebr_0389	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
Trebr_0390	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
Trebr_0393	COG2210	Belongs to the sulfur carrier protein TusA family
Trebr_0395	COG3706	GGDEF domain
Trebr_0396	COG3437	response regulator, receiver
Trebr_0396	COG0784	Response regulator, receiver
Trebr_0397	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
Trebr_0399	COG0004	ammonium transporteR
Trebr_0401	COG0151	Belongs to the GarS family
Trebr_0414	COG0534	Mate efflux family protein
Trebr_0415	COG0475	glutathione-regulated potassium exporter activity
Trebr_0416	COG0534	Mate efflux family protein
Trebr_0417	COG2848	UPF0210 protein
Trebr_0418	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
Trebr_0422	COG1653	transport
Trebr_0423	COG1175	transmembrane transport
Trebr_0424	COG0395	ABC-type sugar transport system, permease component
Trebr_0425	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
Trebr_0427	COG3833	ABC-type maltose transport systems, permease component
Trebr_0438	COG1216	Glycosyl transferase, family 2
Trebr_0439	COG3754	Rhamnan synthesis protein F
Trebr_0443	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
Trebr_0444	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
Trebr_0451	COG0606	chelatase, subunit chli
Trebr_0452	COG1609	Transcriptional regulator
Trebr_0453	COG0613	PHP domain protein
Trebr_0454	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
Trebr_0454	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
Trebr_0457	COG3290	protein histidine kinase activity
Trebr_0457	COG0840	transmembrane signaling receptor activity
Trebr_0459	COG2770	Histidine kinase
Trebr_0459	COG3437	response regulator, receiver
Trebr_0460	COG3263	regulation of cellular component size
Trebr_0461	COG0488	(ABC) transporter
Trebr_0463	COG0583	DNA-binding transcription factor activity
Trebr_0464	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
Trebr_0465	COG1053	succinate dehydrogenase
Trebr_0466	COG1609	Transcriptional regulator
Trebr_0467	COG4209	transmembrane transport
Trebr_0468	COG0395	ABC-type sugar transport system, permease component
Trebr_0471	COG1132	(ABC) transporter
Trebr_0473	COG1119	ATPase activity
Trebr_0474	COG1388	LysM domain
Trebr_0474	COG3858	chitin binding
Trebr_0477	COG0708	Exodeoxyribonuclease III
Trebr_0478	COG0148	phosphopyruvate hydratase activity
Trebr_0483	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
Trebr_0486	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
Trebr_0487	COG0205	6-phosphofructokinase activity
Trebr_0489	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
Trebr_0494	COG0534	Mate efflux family protein
Trebr_0498	COG1516	flagellar protein fliS
Trebr_0499	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
Trebr_0500	COG0534	Mate efflux family protein
Trebr_0502	COG0232	Belongs to the dGTPase family. Type 2 subfamily
Trebr_0505	COG0840	transmembrane signaling receptor activity
Trebr_0508	COG0542	response to heat
Trebr_0512	COG1380	Effector of murein hydrolase LrgA
Trebr_0520	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
Trebr_0523	COG1595	DNA-templated transcription, initiation
Trebr_0525	COG0210	DNA helicase
Trebr_0526	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
Trebr_0529	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
Trebr_0532	COG2197	response regulator
Trebr_0537	COG4214	carbohydrate transport
Trebr_0539	COG4213	ABC transporter substrate-binding protein
Trebr_0540	COG4213	ABC transporter substrate-binding protein
Trebr_0541	COG2207	Transcriptional regulator
Trebr_0541	COG2207	Transcriptional regulator
Trebr_0541	COG4753	response regulator
Trebr_0541	COG4753	response regulator
Trebr_0542	COG2972	Histidine kinase
Trebr_0544	COG3708	Transcriptional regulator
Trebr_0544	COG2207	Transcriptional regulator
Trebr_0547	COG4720	Psort location CytoplasmicMembrane, score
Trebr_0549	COG0138	bifunctional purine biosynthesis protein purh
Trebr_0550	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
Trebr_0552	COG0488	(ABC) transporter
Trebr_0554	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
Trebr_0555	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
Trebr_0560	COG0629	single-stranded DNA binding
Trebr_0563	COG0517	IMP dehydrogenase activity
Trebr_0563	COG1227	inorganic diphosphatase activity
Trebr_0566	COG0564	pseudouridine synthase activity
Trebr_0567	COG0785	Cytochrome C biogenesis protein
Trebr_0570	COG1744	ABC transporter substrate-binding protein PnrA-like
Trebr_0571	COG3845	ABC transporter
Trebr_0572	COG4603	Belongs to the binding-protein-dependent transport system permease family
Trebr_0573	COG1079	Belongs to the binding-protein-dependent transport system permease family
Trebr_0575	COG0840	transmembrane signaling receptor activity
Trebr_0576	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
Trebr_0577	COG0513	Belongs to the DEAD box helicase family
Trebr_0588	COG0445	tRNA wobble uridine modification
Trebr_0589	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
Trebr_0590	COG1164	Oligoendopeptidase f
Trebr_0591	COG0514	ATP-dependent DNA helicase (RecQ)
Trebr_0592	COG2885	chlorophyll binding
Trebr_0595	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
Trebr_0596	COG1177	transmembrane transport
Trebr_0597	COG1176	ABC-type spermidine putrescine transport system, permease component I
Trebr_0598	COG3842	ATPase activity
Trebr_0600	COG1687	branched-chain amino acid
Trebr_0601	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
Trebr_0604	COG3956	TIGRFAM MazG family protein
Trebr_0605	COG0193	aminoacyl-tRNA hydrolase activity
Trebr_0606	COG0740	serine-type endopeptidase activity
Trebr_0608	COG0724	RNA recognition motif
Trebr_0610	COG1283	sodium-dependent phosphate transmembrane transporter activity
Trebr_0614	COG1126	abc transporter atp-binding protein
Trebr_0615	COG0765	amino acid transport
Trebr_0616	COG0525	valine-tRNA ligase activity
Trebr_0618	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
Trebr_0621	COG2203	Gaf domain
Trebr_0621	COG3706	GGDEF domain
Trebr_0621	COG4251	negative regulation of phosphorylation
Trebr_0621	COG5001	Diguanylate cyclase
Trebr_0623	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
Trebr_0626	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
Trebr_0627	COG1469	GTP cyclohydrolase I activity
Trebr_0629	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
Trebr_0633	COG2226	methyltransferase
Trebr_0634	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
Trebr_0635	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
Trebr_0636	COG2137	regulation of response to DNA damage stimulus
Trebr_0637	COG0745	RESPONSE REGULATOR receiver
Trebr_0640	COG2208	phosphoserine phosphatase activity
Trebr_0641	COG0616	signal peptide processing
Trebr_0644	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
Trebr_0646	COG1917	Cupin 2, conserved barrel domain protein
Trebr_0646	COG2207	Transcriptional regulator
Trebr_0647	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
Trebr_0652	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
Trebr_0654	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
Trebr_0655	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
Trebr_0656	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
Trebr_0657	COG2610	gluconate transmembrane transporter activity
Trebr_0659	COG3395	kinase activity
Trebr_0660	COG1349	DNA-binding transcription factor activity
Trebr_0661	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
Trebr_0663	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
Trebr_0665	COG1725	Transcriptional regulator
Trebr_0666	COG1131	(ABC) transporter
Trebr_0668	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
Trebr_0670	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
Trebr_0674	COG0067	glutamate synthase
Trebr_0675	COG0069	glutamate synthase activity
Trebr_0675	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
Trebr_0680	COG1074	ATP-dependent DNA helicase activity
Trebr_0684	COG0366	Alpha amylase catalytic
Trebr_0685	COG1523	belongs to the glycosyl hydrolase 13 family
Trebr_0686	COG2182	Extracellular solute-binding protein
Trebr_0687	COG1175	transmembrane transport
Trebr_0688	COG3833	ABC-type maltose transport systems, permease component
Trebr_0693	COG0367	asparagine synthase
Trebr_0694	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
Trebr_0695	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
Trebr_0697	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
Trebr_0702	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
Trebr_0703	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
Trebr_0704	COG0704	Plays a role in the regulation of phosphate uptake
Trebr_0706	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
Trebr_0708	COG0788	formyltetrahydrofolate deformylase activity
Trebr_0710	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
Trebr_0710	COG0426	domain, Protein
Trebr_0712	COG3275	phosphorelay sensor kinase activity
Trebr_0713	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
Trebr_0714	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
Trebr_0717	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
Trebr_0718	COG1418	mRNA catabolic process
Trebr_0720	COG2201	protein-glutamate methylesterase activity
Trebr_0723	COG0142	geranyltranstransferase activity
Trebr_0724	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
Trebr_0725	COG0741	lytic transglycosylase activity
Trebr_0725	COG0739	heme binding
Trebr_0725	COG1196	nuclear chromosome segregation
Trebr_0726	COG1396	sequence-specific DNA binding
Trebr_0728	COG0028	Belongs to the TPP enzyme family
Trebr_0729	COG0563	adenylate kinase activity
Trebr_0733	COG2244	polysaccharide biosynthetic process
Trebr_0736	COG1181	Belongs to the D-alanine--D-alanine ligase family
Trebr_0739	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
Trebr_0751	COG0107	imidazoleglycerol-phosphate synthase activity
Trebr_0752	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
Trebr_0753	COG0459	protein refolding
Trebr_0754	COG0328	RNA-DNA hybrid ribonuclease activity
Trebr_0755	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
Trebr_0756	COG1686	Belongs to the peptidase S11 family
Trebr_0758	COG0028	Belongs to the TPP enzyme family
Trebr_0759	COG0436	Aminotransferase
Trebr_0762	COG0643	Histidine kinase
Trebr_0762	COG2198	Histidine kinase
Trebr_0763	COG0835	chemotaxis
Trebr_0765	COG2201	protein-glutamate methylesterase activity
Trebr_0767	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
Trebr_0768	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
Trebr_0769	COG0037	tRNA processing
Trebr_0771	COG0745	RESPONSE REGULATOR receiver
Trebr_0771	COG3706	GGDEF domain
Trebr_0772	COG0012	GTP binding
Trebr_0782	COG0423	glycine-tRNA ligase activity
Trebr_0784	COG0227	Belongs to the bacterial ribosomal protein bL28 family
Trebr_0785	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
Trebr_0787	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
Trebr_0788	COG1028	Short-chain dehydrogenase reductase Sdr
Trebr_0789	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
Trebr_0790	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
Trebr_0791	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
Trebr_0793	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
Trebr_0794	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
Trebr_0795	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
Trebr_0796	COG0762	integral membrane protein
Trebr_0797	COG0587	DNA-directed DNA polymerase activity
Trebr_0798	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
Trebr_0799	COG2011	ABC-type metal ion transport system permease component
Trebr_0800	COG1464	Belongs to the NlpA lipoprotein family
Trebr_0802	COG5002	protein histidine kinase activity
Trebr_0808	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
Trebr_0811	COG0028	Belongs to the TPP enzyme family
Trebr_0812	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
Trebr_0814	COG1088	dTDP-glucose 4,6-dehydratase activity
Trebr_0819	COG3754	Rhamnan synthesis protein F
Trebr_0824	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
Trebr_0829	COG1862	Preprotein translocase
Trebr_0830	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
Trebr_0831	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
Trebr_0832	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
Trebr_0833	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
Trebr_0834	COG0126	phosphoglycerate kinase activity
Trebr_0836	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
Trebr_0838	COG1028	Short-chain dehydrogenase reductase Sdr
Trebr_0839	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
Trebr_0840	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
Trebr_0842	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
Trebr_0843	COG2207	Transcriptional regulator
Trebr_0845	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
Trebr_0847	COG0493	'glutamate synthase
Trebr_0848	COG3070	regulator of competence-specific genes
Trebr_0852	COG2878	Part of a membrane complex involved in electron transport
Trebr_0852	COG1245	4Fe-4S binding domain
Trebr_0853	COG4657	Part of a membrane complex involved in electron transport
Trebr_0854	COG4660	Part of a membrane complex involved in electron transport
Trebr_0856	COG4658	electron transport chain
Trebr_0857	COG4656	Part of a membrane complex involved in electron transport
Trebr_0860	COG2199	diguanylate cyclase activity
Trebr_0860	COG2200	EAL domain
Trebr_0860	COG3287	FIST C domain
Trebr_0862	COG0840	transmembrane signaling receptor activity
Trebr_0865	COG2885	chlorophyll binding
Trebr_0870	COG1773	rubredoxin
Trebr_0871	COG0577	efflux transmembrane transporter activity
Trebr_0871	COG1136	(ABC) transporter
Trebr_0872	COG1136	(ABC) transporter
Trebr_0873	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
Trebr_0875	COG0504	CTP synthase activity
Trebr_0878	COG1137	ATPase activity
Trebr_0879	COG2703	oxygen carrier activity
Trebr_0884	COG1739	Uncharacterized protein family UPF0029
Trebr_0886	COG0017	Asparaginyl-tRNA synthetase
Trebr_0888	COG1720	tRNA m6t6A37 methyltransferase activity
Trebr_0890	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
Trebr_0894	COG3706	GGDEF domain
Trebr_0897	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
Trebr_0898	COG0018	arginyl-trna synthetase
Trebr_0900	COG0840	transmembrane signaling receptor activity
Trebr_0900	COG5278	phosphoserine phosphatase activity
Trebr_0902	COG0228	four-way junction DNA binding
Trebr_0903	COG1837	Belongs to the UPF0109 family
Trebr_0904	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
Trebr_0905	COG0336	Belongs to the RNA methyltransferase TrmD family
Trebr_0906	COG0335	large ribosomal subunit rRNA binding
Trebr_0910	COG0792	nuclease activity
Trebr_0918	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
Trebr_0924	COG1136	(ABC) transporter
Trebr_0924	COG0577	efflux transmembrane transporter activity
Trebr_0928	COG1136	(ABC) transporter
Trebr_0931	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
Trebr_0934	COG3437	response regulator, receiver
Trebr_0934	COG2770	Histidine kinase
Trebr_0935	COG1671	Belongs to the UPF0178 family
Trebr_0936	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
Trebr_0938	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
Trebr_0939	COG0291	Belongs to the bacterial ribosomal protein bL35 family
Trebr_0940	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
Trebr_0942	COG0191	fructose-bisphosphate aldolase activity
Trebr_0946	COG2001	Belongs to the MraZ family
Trebr_0947	COG0275	rRNA processing
Trebr_0949	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
Trebr_0950	COG0772	Belongs to the SEDS family
Trebr_0951	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
Trebr_0957	COG0551	DNA topoisomerase type I activity
Trebr_0957	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
Trebr_0958	COG4974	Belongs to the 'phage' integrase family
Trebr_0959	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
Trebr_0960	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
Trebr_0961	COG1815	bacterial-type flagellum-dependent cell motility
Trebr_0963	COG1677	Flagellar hook-basal body complex protein FliE
Trebr_0964	COG1766	The M ring may be actively involved in energy transduction
Trebr_0966	COG1317	bacterial-type flagellum organization
Trebr_0967	COG1157	protein secretion by the type III secretion system
Trebr_0969	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
Trebr_0971	COG0301	tRNA thio-modification
Trebr_0972	COG1022	Amp-dependent synthetase and ligase
Trebr_0977	COG2095	MarC family integral membrane protein
Trebr_0980	COG0765	amino acid transport
Trebr_0983	COG1480	7TM receptor with intracellular HD hydrolase
Trebr_0984	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
Trebr_0991	COG0552	protein localization to endoplasmic reticulum
Trebr_0993	COG4591	ABC-type transport system involved in lipoprotein release permease component
Trebr_0994	COG1136	(ABC) transporter
Trebr_0997	COG3869	Catalyzes the specific phosphorylation of arginine residues in
Trebr_1003	COG2205	protein histidine kinase activity
Trebr_1008	COG1309	transcriptional regulator
Trebr_1010	COG1683	Conserved Protein
Trebr_1013	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
Trebr_1024	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
Trebr_1028	COG0330	HflC and HflK could
Trebr_1029	COG0330	HflC and HflK could
Trebr_1030	COG1309	transcriptional regulator
Trebr_1032	COG1132	(ABC) transporter
Trebr_1034	COG0789	Transcriptional regulator
Trebr_1039	COG0596	Alpha beta hydrolase
Trebr_1044	COG0693	protein deglycase activity
Trebr_1045	COG2378	regulation of single-species biofilm formation
Trebr_1047	COG1373	ATPase (AAA superfamily
Trebr_1048	COG2226	methyltransferase
Trebr_1054	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
Trebr_1055	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
Trebr_1058	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
Trebr_1075	COG0504	CTP synthase activity
Trebr_1077	COG0105	UTP biosynthetic process
Trebr_1078	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
Trebr_1079	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
Trebr_1080	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
Trebr_1081	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
Trebr_1082	COG1609	Transcriptional regulator
Trebr_1083	COG1879	ABC-type sugar transport system periplasmic component
Trebr_1084	COG1129	ABC transporter
Trebr_1085	COG4211	Belongs to the binding-protein-dependent transport system permease family
Trebr_1086	COG0800	Aldolase
Trebr_1087	COG0640	Transcriptional regulator
Trebr_1088	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
Trebr_1088	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
Trebr_1089	COG1381	Involved in DNA repair and RecF pathway recombination
Trebr_1090	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
Trebr_1091	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
Trebr_1094	COG0084	hydrolase, TatD family'
Trebr_1096	COG0681	Belongs to the peptidase S26 family
Trebr_1098	COG1108	ABC-type Mn2 Zn2 transport systems permease components
Trebr_1101	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
Trebr_1102	COG0154	amidase activity
Trebr_1103	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
Trebr_1108	COG0840	transmembrane signaling receptor activity
Trebr_1108	COG3290	protein histidine kinase activity
Trebr_1110	COG1070	Carbohydrate kinase
Trebr_1112	COG0205	6-phosphofructokinase activity
Trebr_1115	COG0556	nucleotide-excision repair
Trebr_1116	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
Trebr_1117	COG0321	lipoyl(octanoyl) transferase activity
Trebr_1117	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
Trebr_1124	COG0456	acetyltransferase
Trebr_1136	COG0823	Involved in the tonB-independent uptake of proteins
Trebr_1138	COG1987	bacterial-type flagellum assembly
Trebr_1139	COG1684	flagellar biosynthetic protein fliR
Trebr_1140	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
Trebr_1141	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
Trebr_1143	COG0455	bacterial-type flagellum organization
Trebr_1145	COG1191	sigma factor activity
Trebr_1151	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
Trebr_1154	COG3852	Histidine kinase
Trebr_1155	COG2204	response regulator
Trebr_1156	COG1846	Transcriptional regulator
Trebr_1159	COG1078	dGTPase activity
Trebr_1160	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
Trebr_1162	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
Trebr_1163	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
Trebr_1164	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
Trebr_1165	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
Trebr_1167	COG0736	holo-[acyl-carrier-protein] synthase activity
Trebr_1169	COG0101	tRNA pseudouridine synthase activity
Trebr_1170	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
Trebr_1171	COG1573	uracil-dna glycosylase
Trebr_1174	COG2033	superoxide reductase activity
Trebr_1176	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
Trebr_1177	COG2968	Membrane
Trebr_1178	COG0840	transmembrane signaling receptor activity
Trebr_1179	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
Trebr_1183	COG1390	Produces ATP from ADP in the presence of a proton gradient across the membrane
Trebr_1185	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
Trebr_1186	COG1156	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit
Trebr_1187	COG1394	ATPase activity, coupled to movement of substances
Trebr_1188	COG1269	ATP hydrolysis coupled proton transport
Trebr_1190	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
Trebr_1197	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
Trebr_1199	COG1122	ATPase activity
Trebr_1200	COG1268	BioY protein
Trebr_1201	COG0815	Transfers the fatty acyl group on membrane lipoproteins
Trebr_1202	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
Trebr_1203	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
Trebr_1206	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
Trebr_1210	COG0220	tRNA (guanine-N7-)-methyltransferase activity
Trebr_1211	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
Trebr_1213	COG0739	heme binding
Trebr_1222	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
Trebr_1227	COG1120	ATPase activity
Trebr_1228	COG4753	response regulator
Trebr_1228	COG2207	Transcriptional regulator
Trebr_1229	COG2972	Histidine kinase
Trebr_1230	COG1129	ABC transporter
Trebr_1231	COG1129	ABC transporter
Trebr_1232	COG1172	Belongs to the binding-protein-dependent transport system permease family
Trebr_1242	COG0583	DNA-binding transcription factor activity
Trebr_1243	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
Trebr_1244	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
Trebr_1247	COG0803	Belongs to the bacterial solute-binding protein 9 family
Trebr_1249	COG1108	ABC-type Mn2 Zn2 transport systems permease components
Trebr_1255	COG0343	queuine tRNA-ribosyltransferase activity
Trebr_1257	COG0835	chemotaxis
Trebr_1259	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
Trebr_1260	COG0497	DNA recombination
Trebr_1262	COG1744	ABC transporter substrate-binding protein PnrA-like
Trebr_1266	COG3842	ATPase activity
Trebr_1267	COG0557	exoribonuclease II activity
Trebr_1268	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
Trebr_1275	COG0534	Mate efflux family protein
Trebr_1276	COG1940	carbohydrate kinase activity
Trebr_1276	COG1846	Transcriptional regulator
Trebr_1277	COG1509	lysine 2,3-aminomutase activity
Trebr_1278	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
Trebr_1279	COG0137	argininosuccinate synthase activity
Trebr_1281	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
Trebr_1283	COG2814	Major facilitator Superfamily
Trebr_1284	COG1811	Na channel or pump
Trebr_1286	COG0513	Belongs to the DEAD box helicase family
Trebr_1287	COG0488	(ABC) transporter
Trebr_1290	COG1234	tRNA 3'-trailer cleavage
Trebr_1291	COG4555	ABC transporter
Trebr_1299	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
Trebr_1300	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
Trebr_1304	COG1840	ABC-type Fe3 transport system, periplasmic component
Trebr_1306	COG3842	ATPase activity
Trebr_1307	COG0285	dihydrofolate synthase activity
Trebr_1308	COG0653	protein targeting
Trebr_1312	COG0494	nUDIX hydrolase
Trebr_1315	COG1450	Type ii and iii secretion system protein
Trebr_1316	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
Trebr_1317	COG1459	type II secretion system
Trebr_1341	COG0124	histidyl-tRNA synthetase
Trebr_1342	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
Trebr_1343	COG2252	PERMEase
Trebr_1345	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
Trebr_1347	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
Trebr_1354	COG1011	Hydrolase
Trebr_1355	COG0772	Belongs to the SEDS family
Trebr_1356	COG0768	penicillin binding
Trebr_1359	COG1077	Cell shape determining protein MreB Mrl
Trebr_1362	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
Trebr_1363	COG0358	DNA primase activity
Trebr_1368	COG0297	glycogen (starch) synthase activity
Trebr_1373	COG0617	tRNA 3'-terminal CCA addition
Trebr_1374	COG0180	Tryptophanyl-tRNA synthetase
Trebr_1376	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
Trebr_1376	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
Trebr_1388	COG0617	tRNA 3'-terminal CCA addition
Trebr_1390	COG0116	Belongs to the methyltransferase superfamily
Trebr_1390	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
Trebr_1393	COG0820	rRNA (adenine-C2-)-methyltransferase activity
Trebr_1395	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
Trebr_1398	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
Trebr_1400	COG3620	sequence-specific DNA binding
Trebr_1401	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
Trebr_1401	COG0574	Belongs to the PEP-utilizing enzyme family
Trebr_1404	COG0569	domain protein
Trebr_1405	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
Trebr_1406	COG0635	Involved in the biosynthesis of porphyrin-containing compound
Trebr_1408	COG1028	Short-chain dehydrogenase reductase Sdr
Trebr_1413	COG0571	ribonuclease III activity
Trebr_1414	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
Trebr_1415	COG0333	Belongs to the bacterial ribosomal protein bL32 family
Trebr_1416	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
Trebr_1418	COG1413	lyase activity
Trebr_1419	COG0424	maF-like protein
Trebr_1420	COG0052	Belongs to the universal ribosomal protein uS2 family
Trebr_1421	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
Trebr_1422	COG0233	cytoplasmic translational termination
Trebr_1423	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
Trebr_1424	COG0575	Belongs to the CDS family
Trebr_1425	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
Trebr_1426	COG0750	zinc metalloprotease
Trebr_1428	COG0305	Participates in initiation and elongation during chromosome replication
Trebr_1429	COG0359	binds to the 23S rRNA
Trebr_1430	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
Trebr_1431	COG0629	single-stranded DNA binding
Trebr_1432	COG0360	Binds together with S18 to 16S ribosomal RNA
Trebr_1433	COG0495	leucyl-tRNA aminoacylation
Trebr_1434	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
Trebr_1442	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
Trebr_1444	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
Trebr_1449	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
Trebr_1451	COG1132	(ABC) transporter
Trebr_1454	COG0828	Belongs to the bacterial ribosomal protein bS21 family
Trebr_1460	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
Trebr_1461	COG0812	UDP-N-acetylmuramate dehydrogenase activity
Trebr_1462	COG0215	cysteine-tRNA ligase activity
Trebr_1466	COG0528	UMP kinase activity
Trebr_1468	COG2003	Belongs to the UPF0758 family
Trebr_1470	COG0667	Aldo Keto reductase
Trebr_1471	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
Trebr_1472	COG0542	response to heat
Trebr_1476	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
Trebr_1479	COG0632	four-way junction helicase activity
Trebr_1480	COG2255	four-way junction helicase activity
Trebr_1481	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
Trebr_1482	COG1592	Rubrerythrin
Trebr_1482	COG1773	rubredoxin
Trebr_1487	COG0084	hydrolase, TatD family'
Trebr_1488	COG0840	transmembrane signaling receptor activity
Trebr_1493	COG2201	protein-glutamate methylesterase activity
Trebr_1496	COG0484	heat shock protein binding
Trebr_1497	COG0443	Heat shock 70 kDa protein
Trebr_1498	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
Trebr_1500	COG2502	aspartate--ammonia ligase
Trebr_1504	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
Trebr_1510	COG3216	Uncharacterized protein conserved in bacteria (DUF2062)
Trebr_1511	COG0297	glycogen (starch) synthase activity
Trebr_1512	COG0436	Aminotransferase
Trebr_1514	COG0662	Cupin 2, conserved barrel domain protein
Trebr_1514	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
Trebr_1515	COG2089	acid synthase
Trebr_1516	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
Trebr_1518	COG0009	L-threonylcarbamoyladenylate synthase
Trebr_1526	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
Trebr_1528	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
Trebr_1530	COG1102	Psort location Cytoplasmic, score
Trebr_1531	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
Trebr_1534	COG1716	ATPase activity
Trebr_1534	COG0842	Transport permease protein
Trebr_1534	COG1131	(ABC) transporter
Trebr_1535	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
Trebr_1536	COG0217	transcriptional regulatory protein
Trebr_1537	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
Trebr_1542	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
Trebr_1543	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
Trebr_1546	COG1334	flagellar protein FlaG
Trebr_1550	COG0802	atpase or kinase
Trebr_1552	COG5492	domain, Protein
Trebr_1556	COG5492	domain, Protein
Trebr_1558	COG0395	ABC-type sugar transport system, permease component
Trebr_1559	COG4209	transmembrane transport
Trebr_1560	COG3708	Transcriptional regulator
Trebr_1560	COG2207	Transcriptional regulator
Trebr_1562	COG1028	Short-chain dehydrogenase reductase Sdr
Trebr_1563	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
Trebr_1566	COG2207	Transcriptional regulator
Trebr_1569	COG1196	nuclear chromosome segregation
Trebr_1576	COG0544	peptidyl-prolyl cis-trans isomerase activity
Trebr_1577	COG0740	serine-type endopeptidase activity
Trebr_1578	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
Trebr_1582	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
Trebr_1584	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
Trebr_1585	COG2911	Protein conserved in bacteria
Trebr_1586	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
Trebr_1588	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
Trebr_1589	COG1104	cysteine desulfurase activity
Trebr_1592	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
Trebr_1593	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
Trebr_1595	COG1388	LysM domain
Trebr_1595	COG3942	CHAP domain
Trebr_1597	COG1338	Plays a role in the flagellum-specific transport system
Trebr_1600	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
Trebr_1601	COG1580	Controls the rotational direction of flagella during chemotaxis
Trebr_1602	COG1360	Flagellar Motor Protein
Trebr_1603	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
Trebr_1606	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
Trebr_1608	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
Trebr_1612	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
Trebr_1616	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
Trebr_1619	COG5002	protein histidine kinase activity
Trebr_1620	COG0745	RESPONSE REGULATOR receiver
Trebr_1623	COG0512	Glutamine amidotransferase of anthranilate synthase
Trebr_1623	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
Trebr_1624	COG0134	indole-3-glycerol-phosphate synthase activity
Trebr_1625	COG0133	tryptophan synthase activity
Trebr_1626	COG0159	tryptophan synthase activity
Trebr_1627	COG3525	Glycosyl hydrolase, family 20, catalytic domain
Trebr_1630	COG0519	Catalyzes the synthesis of GMP from XMP
Trebr_1631	COG1086	Polysaccharide biosynthesis protein
Trebr_1632	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
Trebr_1636	COG0698	ribose 5-phosphate isomerase
Trebr_1638	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
Trebr_1642	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
Trebr_1650	COG0438	transferase activity, transferring glycosyl groups
Trebr_1651	COG1216	Glycosyl transferase, family 2
Trebr_1661	COG1162	GTPase activity
Trebr_1662	COG1193	negative regulation of DNA recombination
Trebr_1663	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
Trebr_1663	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
Trebr_1663	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
Trebr_1664	COG0295	cytidine deaminase activity
Trebr_1668	COG1104	cysteine desulfurase activity
Trebr_1671	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
Trebr_1672	COG2843	Capsule synthesis protein
Trebr_1673	COG1283	sodium-dependent phosphate transmembrane transporter activity
Trebr_1674	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
Trebr_1675	COG4585	Histidine kinase
Trebr_1676	COG2197	response regulator
Trebr_1681	COG3842	ATPase activity
Trebr_1683	COG4143	(ABC) transporter
Trebr_1689	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
Trebr_1690	COG0527	aspartate kinase activity
Trebr_1691	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
Trebr_1692	COG0024	Methionine aminopeptidase
Trebr_1693	COG0484	heat shock protein binding
Trebr_1696	COG1394	ATPase activity, coupled to movement of substances
Trebr_1697	COG1156	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit
Trebr_1698	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
Trebr_1702	COG1269	ATP hydrolysis coupled proton transport
Trebr_1705	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
Trebr_1706	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
Trebr_1707	COG0149	triose-phosphate isomerase activity
Trebr_1709	COG5001	Diguanylate cyclase
Trebr_1709	COG3300	MHYT domain
Trebr_1710	COG1187	pseudouridine synthase activity
Trebr_1711	COG1414	Transcriptional regulator
Trebr_1712	COG0372	Belongs to the citrate synthase family
Trebr_1713	COG0564	pseudouridine synthase activity
Trebr_1715	COG0724	RNA recognition motif
Trebr_1719	COG2204	response regulator
Trebr_1720	COG0539	negative regulation of cytoplasmic translation
Trebr_1721	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
Trebr_1723	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
Trebr_1724	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
Trebr_1726	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
Trebr_1730	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
Trebr_1732	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
Trebr_1732	COG1747	RNA polymerase binding
Trebr_1733	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
Trebr_1734	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
Trebr_1735	COG1475	DNA binding
Trebr_1743	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
Trebr_1746	COG0280	phosphate acetyltransferase
Trebr_1750	COG0739	heme binding
Trebr_1755	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
Trebr_1756	COG1086	Polysaccharide biosynthesis protein
Trebr_1760	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
Trebr_1762	COG0534	Mate efflux family protein
Trebr_1765	COG0481	GTPase activity
Trebr_1766	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
Trebr_1769	COG0037	tRNA processing
Trebr_1770	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
Trebr_1772	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
Trebr_1776	COG1713	HD superfamily hydrolase involved in NAD metabolism
Trebr_1777	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
Trebr_1778	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
Trebr_1779	COG0211	Belongs to the bacterial ribosomal protein bL27 family
Trebr_1781	COG0261	This protein binds to 23S rRNA in the presence of protein L20
Trebr_1789	COG1132	(ABC) transporter
Trebr_1790	COG1132	(ABC) transporter
Trebr_1791	COG2378	regulation of single-species biofilm formation
Trebr_1794	COG0840	transmembrane signaling receptor activity
Trebr_1807	COG0438	transferase activity, transferring glycosyl groups
Trebr_1814	COG1438	arginine binding
Trebr_1819	COG0166	Belongs to the GPI family
Trebr_1823	COG0420	3'-5' exonuclease activity
Trebr_1824	COG0419	ATPase involved in DNA repair
Trebr_1826	COG0516	GMP reductase activity
Trebr_1826	COG0517	IMP dehydrogenase activity
Trebr_1827	COG0564	pseudouridine synthase activity
Trebr_1828	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
Trebr_1832	COG1199	ATP-dependent helicase activity
Trebr_1836	COG0860	N-Acetylmuramoyl-L-alanine amidase
Trebr_1836	COG2247	cell wall binding repeat
Trebr_1837	COG0151	Belongs to the GarS family
Trebr_1838	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
Trebr_1843	COG1722	exodeoxyribonuclease VII activity
Trebr_1844	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
Trebr_1851	COG1366	Belongs to the anti-sigma-factor antagonist family
Trebr_1853	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
Trebr_1854	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
Trebr_1855	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
Trebr_1858	COG2217	Heavy metal translocating P-type atpase
Trebr_1859	COG1937	Protein conserved in bacteria
Trebr_1861	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
Trebr_1872	COG1216	Glycosyl transferase, family 2
Trebr_1875	COG0463	Glycosyl transferase, family 2
Trebr_1880	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
Trebr_1881	COG1181	Belongs to the D-alanine--D-alanine ligase family
Trebr_1882	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
Trebr_1884	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
Trebr_1885	COG4786	Flagellar basal body rod
Trebr_1888	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
Trebr_1889	COG1482	cell wall glycoprotein biosynthetic process
Trebr_1892	COG0813	purine-nucleoside phosphorylase activity
Trebr_1896	COG2059	Chromate
Trebr_1897	COG0534	Mate efflux family protein
Trebr_1898	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
Trebr_1900	COG1116	anion transmembrane transporter activity
Trebr_1903	COG3977	Valine--pyruvate aminotransferase
Trebr_1905	COG3437	response regulator, receiver
Trebr_1906	COG0815	Transfers the fatty acyl group on membrane lipoproteins
Trebr_1908	COG0268	Binds directly to 16S ribosomal RNA
Trebr_1909	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
Trebr_1909	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
Trebr_1910	COG0564	pseudouridine synthase activity
Trebr_1911	COG1472	Belongs to the glycosyl hydrolase 3 family
Trebr_1913	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
Trebr_1915	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
Trebr_1916	COG2942	2-epimerase
Trebr_1917	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
Trebr_1921	COG1175	transmembrane transport
Trebr_1926	COG1609	Transcriptional regulator
Trebr_1932	COG4452	Inner membrane protein CreD
Trebr_1936	COG0768	penicillin binding
Trebr_1938	COG0739	heme binding
Trebr_1941	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
Trebr_1944	COG4166	transmembrane transport
Trebr_1945	COG1329	Transcriptional regulator
Trebr_1946	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
Trebr_1946	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
Trebr_1950	COG0848	biopolymer transport protein
Trebr_1951	COG0811	peptide transport
Trebr_1959	COG0728	peptidoglycan biosynthetic process
Trebr_1960	COG0006	proline dipeptidase activity
Trebr_1963	COG0322	excinuclease ABC activity
Trebr_1964	COG0612	Peptidase, M16
Trebr_1965	COG1185	polyribonucleotide nucleotidyltransferase activity
Trebr_1966	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
Trebr_1968	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
Trebr_1969	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
Trebr_1970	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
Trebr_1972	COG0779	Required for maturation of 30S ribosomal subunits
Trebr_1986	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
Trebr_1990	COG0813	purine-nucleoside phosphorylase activity
Trebr_1991	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
Trebr_2000	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
Trebr_2011	COG0659	secondary active sulfate transmembrane transporter activity
Trebr_2015	COG2050	protein possibly involved in aromatic compounds catabolism
Trebr_2017	COG0395	ABC-type sugar transport system, permease component
Trebr_2018	COG1175	transmembrane transport
Trebr_2022	COG0363	glucosamine-6-phosphate deaminase activity
Trebr_2023	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
Trebr_2024	COG3459	Glycosyltransferase 36 associated
Trebr_2028	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
Trebr_2034	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
Trebr_2037	COG0114	fumarate hydratase activity
Trebr_2038	COG0039	L-malate dehydrogenase activity
Trebr_2040	COG0640	Transcriptional regulator
Trebr_2042	COG2233	PERMEase
Trebr_2044	COG0840	transmembrane signaling receptor activity
Trebr_2045	COG0473	3-isopropylmalate dehydrogenase activity
Trebr_2053	COG1442	glycosyl transferase family 8
Trebr_2053	COG1216	Glycosyl transferase, family 2
Trebr_2062	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
Trebr_2063	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
Trebr_2065	COG1172	Belongs to the binding-protein-dependent transport system permease family
Trebr_2066	COG1129	ABC transporter
Trebr_2067	COG2942	2-epimerase
Trebr_2069	COG2217	Heavy metal translocating P-type atpase
Trebr_2072	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
Trebr_2075	COG0237	dephospho-CoA kinase activity
Trebr_2076	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
Trebr_2076	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
Trebr_2076	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
Trebr_2083	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
Trebr_2084	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
Trebr_2087	COG0784	Response regulator, receiver
Trebr_2087	COG2205	protein histidine kinase activity
Trebr_2087	COG5002	protein histidine kinase activity
Trebr_2090	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
Trebr_2091	COG0484	heat shock protein binding
Trebr_2098	COG0714	Associated with various cellular activities
Trebr_2102	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
Trebr_2105	COG0254	rRNA binding
Trebr_2106	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
Trebr_2109	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
Trebr_2113	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
Trebr_2114	COG2890	protein-(glutamine-N5) methyltransferase activity
Trebr_2115	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
Trebr_2117	COG4716	Myosin-crossreactive antigen
Trebr_2122	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
Trebr_2125	COG0494	nUDIX hydrolase
Trebr_2128	COG4443	Transcriptional Coactivator p15 (PC4)
Trebr_2131	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
Trebr_2135	COG4536	flavin adenine dinucleotide binding
Trebr_2136	COG4536	flavin adenine dinucleotide binding
Trebr_2138	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
Trebr_2142	COG1522	sequence-specific DNA binding
Trebr_2143	COG0436	Aminotransferase
Trebr_2145	COG1122	ATPase activity
Trebr_2147	COG0530	calcium, potassium:sodium antiporter activity
Trebr_2149	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
Trebr_2150	COG1136	(ABC) transporter
Trebr_2151	COG0577	efflux transmembrane transporter activity
Trebr_2152	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
Trebr_2153	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
Trebr_2154	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
Trebr_2155	COG3118	belongs to the thioredoxin family
Trebr_2160	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
Trebr_2161	COG0534	Mate efflux family protein
Trebr_2164	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
Trebr_2166	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
Trebr_2169	COG1131	(ABC) transporter
Trebr_2174	COG1518	maintenance of DNA repeat elements
Trebr_2187	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
Trebr_2188	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
Trebr_2191	COG0242	peptide deformylase activity
Trebr_2192	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
Trebr_2194	COG1757	Na H antiporter
Trebr_2195	COG0840	transmembrane signaling receptor activity
Trebr_2197	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
Trebr_2199	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
Trebr_2201	COG0058	SHG alpha-glucan phosphorylase activity
Trebr_2202	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
Trebr_2206	COG0492	ferredoxin-NADP+ reductase activity
Trebr_2212	COG0701	Predicted permease
Trebr_2214	COG0596	Alpha beta hydrolase
Trebr_2216	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
Trebr_2220	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
Trebr_2220	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
Trebr_2220	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
Trebr_2225	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
Trebr_2227	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
Trebr_2238	COG1640	4-alpha-glucanotransferase
Trebr_2240	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
Trebr_2244	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
Trebr_2249	COG1028	Short-chain dehydrogenase reductase Sdr
Trebr_2250	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
Trebr_2253	COG1385	rRNA (uridine-N3-)-methyltransferase activity
Trebr_2254	COG0793	Belongs to the peptidase S41A family
Trebr_2256	COG0455	bacterial-type flagellum organization
Trebr_2257	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
Trebr_2258	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
Trebr_2259	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
Trebr_2262	COG0516	GMP reductase activity
Trebr_2262	COG0517	IMP dehydrogenase activity
Trebr_2264	COG0411	ABC transporter
Trebr_2266	COG0559	Belongs to the binding-protein-dependent transport system permease family
Trebr_2269	COG0203	ribosomal protein L17
Trebr_2270	COG0202	RNA polymerase activity
Trebr_2271	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
Trebr_2272	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
Trebr_2273	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
Trebr_2274	COG0257	Belongs to the bacterial ribosomal protein bL36 family
Trebr_2276	COG0200	Binds to the 23S rRNA
Trebr_2277	COG1841	ribosomal large subunit assembly
Trebr_2278	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
Trebr_2279	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
Trebr_2280	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
Trebr_2281	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
Trebr_2282	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
Trebr_2283	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
Trebr_2284	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
Trebr_2285	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
Trebr_2286	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
Trebr_2287	COG0255	Belongs to the universal ribosomal protein uL29 family
Trebr_2288	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
Trebr_2289	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
Trebr_2290	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
Trebr_2291	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
Trebr_2292	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
Trebr_2293	COG0089	rRNA binding
Trebr_2294	COG0088	Forms part of the polypeptide exit tunnel
Trebr_2295	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
Trebr_2296	COG0051	transcription antitermination factor activity, RNA binding
Trebr_2297	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
Trebr_2298	COG0049	tRNA binding
Trebr_2299	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
Trebr_2300	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
Trebr_2300	COG0739	heme binding
Trebr_2301	COG0085	RNA polymerase activity
Trebr_2302	COG0222	ribosome binding
Trebr_2303	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
Trebr_2304	COG0081	regulation of translation
Trebr_2305	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
Trebr_2306	COG0250	Participates in transcription elongation, termination and antitermination
Trebr_2307	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
Trebr_2308	COG0267	Belongs to the bacterial ribosomal protein bL33 family
Trebr_2309	COG1045	serine acetyltransferase
Trebr_2315	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
Trebr_2316	COG1674	ftsk spoiiie
Trebr_2319	COG1472	Belongs to the glycosyl hydrolase 3 family
Trebr_2321	COG0450	alkyl hydroperoxide reductase
Trebr_2324	COG0543	2 iron, 2 sulfur cluster binding
Trebr_2325	COG0493	'glutamate synthase
Trebr_2326	COG1022	Amp-dependent synthetase and ligase
Trebr_2327	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
Trebr_2331	COG3706	GGDEF domain
Trebr_2331	COG4251	negative regulation of phosphorylation
Trebr_2331	COG5001	Diguanylate cyclase
Trebr_2331	COG2203	Gaf domain
Trebr_2339	COG3116	cell division
Trebr_2339	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
Trebr_2340	COG0084	hydrolase, TatD family'
Trebr_2341	COG0739	heme binding
Trebr_2344	COG1774	PSP1 C-terminal conserved region
Trebr_2347	COG0534	Mate efflux family protein
Trebr_2349	COG1917	Cupin 2, conserved barrel domain protein
Trebr_2349	COG2207	Transcriptional regulator
Trebr_2351	COG1175	transmembrane transport
Trebr_2352	COG0395	ABC-type sugar transport system, permease component
Trebr_2353	COG5426	von Willebrand factor, type A
Trebr_2354	COG0641	radical SAM
Trebr_2355	COG3119	arylsulfatase activity
Trebr_2359	COG1160	GTP binding
Trebr_2362	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
Trebr_2364	COG0628	permease
Trebr_2365	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
Trebr_2365	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
Trebr_2366	COG1854	S-ribosylhomocysteine lyase activity
Trebr_2367	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
Trebr_2368	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
Trebr_2369	COG0494	nUDIX hydrolase
Trebr_2370	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
Trebr_2370	COG0674	pyruvate-flavodoxin oxidoreductase activity
Trebr_2370	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
Trebr_2370	COG1013	pyruvate-flavodoxin oxidoreductase activity
Trebr_2371	COG1752	Esterase of the alpha-beta hydrolase superfamily
Trebr_2372	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
Trebr_2375	COG1385	rRNA (uridine-N3-)-methyltransferase activity
Trebr_2379	COG0357	Ribosomal RNA small subunit methyltransferase G
Trebr_2383	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
Trebr_2384	COG0501	Belongs to the peptidase M48B family
Trebr_2389	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
Trebr_2391	COG3870	Protein conserved in bacteria
Trebr_2400	COG2183	response to ionizing radiation
Trebr_2411	COG1012	belongs to the aldehyde dehydrogenase family
Trebr_2414	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
Trebr_2415	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
Trebr_2416	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
Trebr_2418	COG1643	Atp-dependent helicase
Trebr_2419	COG0840	transmembrane signaling receptor activity
Trebr_2420	COG1272	protein, Hemolysin III
Trebr_2421	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
Trebr_2422	COG3012	SEC-C Motif Domain Protein
Trebr_2427	COG1252	NADH dehydrogenase
Trebr_2428	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
Trebr_2430	COG0326	Molecular chaperone. Has ATPase activity
Trebr_2434	COG0737	Belongs to the 5'-nucleotidase family
Trebr_2436	COG0116	Belongs to the methyltransferase superfamily
Trebr_2441	COG0732	type I restriction modification DNA specificity domain
Trebr_2458	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
Trebr_2465	COG4206	TonB-dependent receptor
Trebr_2466	COG0646	methionine synthase
Trebr_2466	COG1410	methionine synthase
Trebr_2469	COG0463	Glycosyl transferase, family 2
Trebr_2472	COG0789	Transcriptional regulator
Trebr_2473	COG2832	Protein of unknown function (DUF454)
Trebr_2475	COG1131	(ABC) transporter
Trebr_2477	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
Trebr_2478	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
Trebr_2479	COG1120	ATPase activity
Trebr_2482	COG4753	response regulator
Trebr_2482	COG2207	Transcriptional regulator
Trebr_2483	COG2972	Histidine kinase
Trebr_2485	COG0395	ABC-type sugar transport system, permease component
Trebr_2486	COG4209	transmembrane transport
Trebr_2488	COG5520	Belongs to the glycosyl hydrolase 30 family
Trebr_2492	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
Trebr_2495	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
Trebr_2496	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
Trebr_2498	COG1639	'signal transduction protein
Trebr_2502	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
Trebr_2509	COG4953	penicillin-binding protein 1C
Trebr_2511	COG1968	undecaprenyl-diphosphatase activity
Trebr_2514	COG1151	hydroxylamine reductase activity
Trebr_2519	COG0205	6-phosphofructokinase activity
Trebr_2523	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
Trebr_2525	COG2738	Putative neutral zinc metallopeptidase
Trebr_2527	COG1175	transmembrane transport
Trebr_2528	COG0395	ABC-type sugar transport system, permease component
Trebr_2529	COG1011	Hydrolase
Trebr_2531	COG2207	Transcriptional regulator
Trebr_2531	COG4753	response regulator
Trebr_2532	COG2972	Histidine kinase
Trebr_2537	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
Trebr_2540	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
Trebr_2545	COG1940	carbohydrate kinase activity
Trebr_2560	COG0072	phenylalanine-tRNA ligase activity
Trebr_2570	COG0577	efflux transmembrane transporter activity
Trebr_2570	COG1136	(ABC) transporter
Trebr_2578	COG1609	Transcriptional regulator
Trebr_2582	COG0395	ABC-type sugar transport system, permease component
Trebr_2583	COG1175	transmembrane transport
Trebr_2586	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
Trebr_2587	COG0187	DNA topoisomerase II activity
Trebr_R0022	COG1592	Rubrerythrin