locus-tag	class	description
Spica_0001	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
Spica_0002	COG0592	DNA-directed DNA polymerase activity
Spica_0003	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
Spica_0005	COG0230	Belongs to the bacterial ribosomal protein bL34 family
Spica_0006	COG0594	ribonuclease P activity
Spica_0007	COG0706	membrane insertase activity
Spica_0008	COG1847	R3H domain protein
Spica_0012	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
Spica_0016	COG1639	'signal transduction protein
Spica_0017	COG1067	ATP-dependent peptidase activity
Spica_0019	COG0840	transmembrane signaling receptor activity
Spica_0021	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
Spica_0022	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
Spica_0027	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
Spica_0030	COG2816	NAD+ diphosphatase activity
Spica_0032	COG2972	Histidine kinase
Spica_0033	COG3279	Response regulator of the LytR AlgR family
Spica_0034	COG4213	ABC transporter substrate-binding protein
Spica_0035	COG4213	ABC transporter substrate-binding protein
Spica_0037	COG4214	carbohydrate transport
Spica_0038	COG0534	Mate efflux family protein
Spica_0040	COG0739	heme binding
Spica_0042	COG1728	Protein conserved in bacteria
Spica_0043	COG1774	PSP1 C-terminal conserved region
Spica_0046	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
Spica_0048	COG0840	transmembrane signaling receptor activity
Spica_0050	COG2755	lipolytic protein G-D-S-L family
Spica_0055	COG1609	Transcriptional regulator
Spica_0058	COG0494	nUDIX hydrolase
Spica_0060	COG4209	transmembrane transport
Spica_0063	COG1074	ATP-dependent DNA helicase activity
Spica_0066	COG1028	Short-chain dehydrogenase reductase Sdr
Spica_0067	COG1349	DNA-binding transcription factor activity
Spica_0069	COG1523	belongs to the glycosyl hydrolase 13 family
Spica_0073	COG1454	alcohol dehydrogenase
Spica_0074	COG2205	protein histidine kinase activity
Spica_0083	COG0745	RESPONSE REGULATOR receiver
Spica_0085	COG1523	belongs to the glycosyl hydrolase 13 family
Spica_0088	COG3833	ABC-type maltose transport systems, permease component
Spica_0089	COG1175	transmembrane transport
Spica_0094	COG4112	unkown
Spica_0116	COG3706	GGDEF domain
Spica_0116	COG0745	RESPONSE REGULATOR receiver
Spica_0118	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
Spica_0119	COG4702	Belongs to the UPF0303 family
Spica_0122	COG4585	Histidine kinase
Spica_0123	COG2197	response regulator
Spica_0125	COG1879	ABC-type sugar transport system periplasmic component
Spica_0126	COG1879	ABC-type sugar transport system periplasmic component
Spica_0128	COG1172	Belongs to the binding-protein-dependent transport system permease family
Spica_0129	COG0246	Mannitol dehydrogenase
Spica_0134	COG0543	2 iron, 2 sulfur cluster binding
Spica_0135	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
Spica_0135	COG0493	'glutamate synthase
Spica_0136	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
Spica_0137	COG0737	Belongs to the 5'-nucleotidase family
Spica_0142	COG1047	Peptidyl-prolyl cis-trans
Spica_0147	COG0395	ABC-type sugar transport system, permease component
Spica_0148	COG1175	transmembrane transport
Spica_0149	COG1653	transport
Spica_0150	COG2197	response regulator
Spica_0151	COG4585	Histidine kinase
Spica_0152	COG0719	Fe-S assembly protein
Spica_0153	COG0396	ATPase activity
Spica_0156	COG0072	phenylalanine-tRNA ligase activity
Spica_0157	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
Spica_0162	COG3706	GGDEF domain
Spica_0163	COG3116	cell division
Spica_0163	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
Spica_0164	COG0084	hydrolase, TatD family'
Spica_0168	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
Spica_0168	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
Spica_0169	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
Spica_0170	COG0351	phosphomethylpyrimidine kinase
Spica_0171	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
Spica_0175	COG0512	Glutamine amidotransferase of anthranilate synthase
Spica_0175	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
Spica_0177	COG0133	tryptophan synthase activity
Spica_0178	COG0159	tryptophan synthase activity
Spica_0180	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
Spica_0182	COG0205	6-phosphofructokinase activity
Spica_0185	COG2205	protein histidine kinase activity
Spica_0185	COG0784	Response regulator, receiver
Spica_0185	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
Spica_0185	COG2198	Histidine kinase
Spica_0186	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
Spica_0194	COG0483	inositol monophosphate 1-phosphatase activity
Spica_0197	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
Spica_0198	COG2205	protein histidine kinase activity
Spica_0198	COG3437	response regulator, receiver
Spica_0198	COG3850	Histidine kinase
Spica_0198	COG4999	Histidine kinase
Spica_0199	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
Spica_0201	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
Spica_0202	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
Spica_0203	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
Spica_0210	COG0395	ABC-type sugar transport system, permease component
Spica_0211	COG1175	transmembrane transport
Spica_0213	COG2197	response regulator
Spica_0214	COG4585	Histidine kinase
Spica_0222	COG3012	SEC-C Motif Domain Protein
Spica_0223	COG0697	spore germination
Spica_0225	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
Spica_0226	COG0484	heat shock protein binding
Spica_0230	COG1842	Phage shock protein A
Spica_0238	COG1385	rRNA (uridine-N3-)-methyltransferase activity
Spica_0241	COG0455	bacterial-type flagellum organization
Spica_0243	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
Spica_0244	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
Spica_0245	COG0071	Belongs to the small heat shock protein (HSP20) family
Spica_0248	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
Spica_0250	COG1929	Belongs to the glycerate kinase type-1 family
Spica_0251	COG3835	regulator
Spica_0253	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
Spica_0254	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
Spica_0257	COG2814	Major facilitator Superfamily
Spica_0269	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
Spica_0270	COG1285	pathogenesis
Spica_0274	COG1070	Carbohydrate kinase
Spica_0275	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
Spica_0276	COG2885	chlorophyll binding
Spica_0286	COG1328	CTP reductase activity
Spica_0287	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
Spica_0294	COG1022	Amp-dependent synthetase and ligase
Spica_0298	COG0326	Molecular chaperone. Has ATPase activity
Spica_0302	COG1132	(ABC) transporter
Spica_0306	COG1028	Short-chain dehydrogenase reductase Sdr
Spica_0308	COG2197	response regulator
Spica_0310	COG1653	transport
Spica_0311	COG1175	transmembrane transport
Spica_0312	COG0395	ABC-type sugar transport system, permease component
Spica_0321	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
Spica_0322	COG0719	Fe-S assembly protein
Spica_0324	COG0396	ATPase activity
Spica_0326	COG2249	NAD(P)H dehydrogenase (quinone) activity
Spica_0327	COG1385	rRNA (uridine-N3-)-methyltransferase activity
Spica_0331	COG0058	SHG alpha-glucan phosphorylase activity
Spica_0333	COG1595	DNA-templated transcription, initiation
Spica_0337	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
Spica_0340	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
Spica_0341	COG0739	heme binding
Spica_0341	COG0741	lytic transglycosylase activity
Spica_0341	COG1196	nuclear chromosome segregation
Spica_0347	COG0142	geranyltranstransferase activity
Spica_0348	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
Spica_0352	COG1940	carbohydrate kinase activity
Spica_0352	COG1846	Transcriptional regulator
Spica_0353	COG1653	transport
Spica_0354	COG1175	transmembrane transport
Spica_0356	COG3459	Glycosyltransferase 36 associated
Spica_0359	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
Spica_0359	COG1918	ferrous iron import across plasma membrane
Spica_0360	COG4221	oxidoreductase activity
Spica_0361	COG1674	ftsk spoiiie
Spica_0365	COG1322	Protein conserved in bacteria
Spica_0366	COG1030	water channel activity
Spica_0367	COG4864	UPF0365 protein
Spica_0371	COG2211	Major facilitator Superfamily
Spica_0372	COG0267	Belongs to the bacterial ribosomal protein bL33 family
Spica_0373	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
Spica_0374	COG0250	Participates in transcription elongation, termination and antitermination
Spica_0375	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
Spica_0376	COG0081	regulation of translation
Spica_0377	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
Spica_0378	COG0222	ribosome binding
Spica_0379	COG0085	RNA polymerase activity
Spica_0380	COG0739	heme binding
Spica_0380	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
Spica_0381	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
Spica_0382	COG0049	tRNA binding
Spica_0383	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
Spica_0384	COG0051	transcription antitermination factor activity, RNA binding
Spica_0385	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
Spica_0386	COG0088	Forms part of the polypeptide exit tunnel
Spica_0387	COG0089	rRNA binding
Spica_0388	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
Spica_0389	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
Spica_0390	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
Spica_0391	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
Spica_0392	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
Spica_0393	COG0255	Belongs to the universal ribosomal protein uL29 family
Spica_0394	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
Spica_0395	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
Spica_0396	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
Spica_0397	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
Spica_0399	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
Spica_0400	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
Spica_0401	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
Spica_0402	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
Spica_0404	COG0200	Binds to the 23S rRNA
Spica_0406	COG0257	Belongs to the bacterial ribosomal protein bL36 family
Spica_0407	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
Spica_0408	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
Spica_0409	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
Spica_0410	COG0202	RNA polymerase activity
Spica_0411	COG0203	ribosomal protein L17
Spica_0414	COG0559	Belongs to the binding-protein-dependent transport system permease family
Spica_0416	COG0411	ABC transporter
Spica_0417	COG0410	ABC transporter
Spica_0420	COG2890	protein-(glutamine-N5) methyltransferase activity
Spica_0421	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
Spica_0422	COG0457	Tetratricopeptide repeat
Spica_0423	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
Spica_0427	COG0459	protein refolding
Spica_0428	COG1760	l-serine dehydratase
Spica_0429	COG1760	l-serine dehydratase
Spica_0431	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
Spica_0432	COG0328	RNA-DNA hybrid ribonuclease activity
Spica_0433	COG4443	Transcriptional Coactivator p15 (PC4)
Spica_0439	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
Spica_0442	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
Spica_0446	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
Spica_0449	COG0237	dephospho-CoA kinase activity
Spica_0450	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
Spica_0450	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
Spica_0450	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
Spica_0454	COG1085	galactose-1-phosphate uridylyltransferase
Spica_0456	COG0668	transmembrane transport
Spica_0457	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
Spica_0459	COG1534	Rna-binding protein
Spica_0462	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
Spica_0467	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
Spica_0468	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
Spica_0469	COG2137	regulation of response to DNA damage stimulus
Spica_0473	COG1854	S-ribosylhomocysteine lyase activity
Spica_0474	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
Spica_0478	COG5001	Diguanylate cyclase
Spica_0478	COG2203	Gaf domain
Spica_0478	COG4251	negative regulation of phosphorylation
Spica_0478	COG3706	GGDEF domain
Spica_0481	COG0792	nuclease activity
Spica_0485	COG0335	large ribosomal subunit rRNA binding
Spica_0486	COG0336	Belongs to the RNA methyltransferase TrmD family
Spica_0487	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
Spica_0488	COG1837	Belongs to the UPF0109 family
Spica_0489	COG0228	four-way junction DNA binding
Spica_0490	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
Spica_0491	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
Spica_0493	COG0105	UTP biosynthetic process
Spica_0494	COG0101	tRNA pseudouridine synthase activity
Spica_0497	COG1609	Transcriptional regulator
Spica_0499	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
Spica_0508	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
Spica_0510	COG2089	acid synthase
Spica_0511	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
Spica_0512	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
Spica_0514	COG1083	cytidylyl-transferase
Spica_0515	COG1028	Short-chain dehydrogenase reductase Sdr
Spica_0521	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
Spica_0521	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
Spica_0522	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
Spica_0524	COG1086	Polysaccharide biosynthesis protein
Spica_0526	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
Spica_0528	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
Spica_0530	COG1091	dTDP-4-dehydrorhamnose reductase activity
Spica_0540	COG1129	ABC transporter
Spica_0545	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
Spica_0547	COG0724	RNA recognition motif
Spica_0549	COG0148	phosphopyruvate hydratase activity
Spica_0553	COG1575	Belongs to the MenA family. Type 1 subfamily
Spica_0556	COG1752	Esterase of the alpha-beta hydrolase superfamily
Spica_0557	COG1045	serine acetyltransferase
Spica_0559	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
Spica_0560	COG0560	Phosphoserine phosphatase
Spica_0561	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
Spica_0565	COG1196	nuclear chromosome segregation
Spica_0569	COG1487	ribonuclease activity
Spica_0570	COG1525	nuclease
Spica_0571	COG0488	(ABC) transporter
Spica_0577	COG0071	Belongs to the small heat shock protein (HSP20) family
Spica_0578	COG0635	Involved in the biosynthesis of porphyrin-containing compound
Spica_0580	COG1301	dicarboxylic acid transport
Spica_0582	COG1309	transcriptional regulator
Spica_0583	COG0116	Belongs to the methyltransferase superfamily
Spica_0584	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
Spica_0593	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
Spica_0597	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
Spica_0598	COG4209	transmembrane transport
Spica_0599	COG0395	ABC-type sugar transport system, permease component
Spica_0601	COG1312	Catalyzes the dehydration of D-mannonate
Spica_0602	COG3661	Belongs to the glycosyl hydrolase 67 family
Spica_0603	COG1472	Belongs to the glycosyl hydrolase 3 family
Spica_0605	COG1028	Short-chain dehydrogenase reductase Sdr
Spica_0609	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
Spica_0610	COG1304	FMN binding
Spica_0613	COG1802	Transcriptional regulator
Spica_0615	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
Spica_0622	COG0395	ABC-type sugar transport system, permease component
Spica_0624	COG1609	Transcriptional regulator
Spica_0625	COG0800	Aldolase
Spica_0627	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
Spica_0628	COG1028	Short-chain dehydrogenase reductase Sdr
Spica_0629	COG1414	Transcriptional regulator
Spica_0630	COG1904	glucuronate isomerase
Spica_0631	COG0385	Bile acid
Spica_0633	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
Spica_0635	COG4209	transmembrane transport
Spica_0636	COG0395	ABC-type sugar transport system, permease component
Spica_0637	COG1653	transport
Spica_0644	COG0798	PFAM Bile acid sodium symporter
Spica_0646	COG2878	Part of a membrane complex involved in electron transport
Spica_0646	COG1245	4Fe-4S binding domain
Spica_0647	COG4657	Part of a membrane complex involved in electron transport
Spica_0648	COG4660	Part of a membrane complex involved in electron transport
Spica_0649	COG4659	FMN binding
Spica_0650	COG4658	electron transport chain
Spica_0651	COG4656	Part of a membrane complex involved in electron transport
Spica_0654	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
Spica_0655	COG1687	branched-chain amino acid
Spica_0656	COG0840	transmembrane signaling receptor activity
Spica_0657	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
Spica_0658	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
Spica_0660	COG0205	6-phosphofructokinase activity
Spica_0663	COG0528	UMP kinase activity
Spica_0664	COG1305	Transglutaminase-like
Spica_0668	COG0215	cysteine-tRNA ligase activity
Spica_0669	COG0812	UDP-N-acetylmuramate dehydrogenase activity
Spica_0679	COG2003	Belongs to the UPF0758 family
Spica_0680	COG1528	Iron-storage protein
Spica_0682	COG0156	8-amino-7-oxononanoate synthase activity
Spica_0683	COG1342	Belongs to the UPF0251 family
Spica_0692	COG1122	ATPase activity
Spica_0693	COG4721	ABC-type cobalt transport system, permease component
Spica_0694	COG3852	Histidine kinase
Spica_0696	COG2204	response regulator
Spica_0706	COG2894	cell division
Spica_0708	COG0450	alkyl hydroperoxide reductase
Spica_0709	COG3604	Transcriptional regulator
Spica_0710	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
Spica_0713	COG1653	transport
Spica_0714	COG1175	transmembrane transport
Spica_0715	COG0395	ABC-type sugar transport system, permease component
Spica_0716	COG3534	alpha-L-arabinofuranosidase
Spica_0719	COG2801	Transposase and inactivated derivatives
Spica_0720	COG0432	Pfam Uncharacterised protein family UPF0047
Spica_0722	COG1164	Oligoendopeptidase f
Spica_0733	COG0745	RESPONSE REGULATOR receiver
Spica_0734	COG5002	protein histidine kinase activity
Spica_0735	COG1609	Transcriptional regulator
Spica_0737	COG1175	transmembrane transport
Spica_0738	COG0395	ABC-type sugar transport system, permease component
Spica_0739	COG1501	Belongs to the glycosyl hydrolase 31 family
Spica_0741	COG0667	Aldo Keto reductase
Spica_0745	COG1309	transcriptional regulator
Spica_0750	COG0488	(ABC) transporter
Spica_0751	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
Spica_0752	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
Spica_0753	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
Spica_0753	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
Spica_0754	COG1509	lysine 2,3-aminomutase activity
Spica_0755	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
Spica_0756	COG1744	ABC transporter substrate-binding protein PnrA-like
Spica_0760	COG0813	purine-nucleoside phosphorylase activity
Spica_0762	COG0735	belongs to the Fur family
Spica_0763	COG1609	Transcriptional regulator
Spica_0766	COG5002	protein histidine kinase activity
Spica_0768	COG0704	Plays a role in the regulation of phosphate uptake
Spica_0770	COG0613	PHP domain protein
Spica_0771	COG0402	S-adenosylhomocysteine deaminase activity
Spica_0773	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
Spica_0775	COG0366	Alpha amylase catalytic
Spica_0778	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
Spica_0781	COG0018	arginyl-trna synthetase
Spica_0782	COG0261	This protein binds to 23S rRNA in the presence of protein L20
Spica_0784	COG0211	Belongs to the bacterial ribosomal protein bL27 family
Spica_0785	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
Spica_0786	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
Spica_0788	COG0799	negative regulation of ribosome biogenesis
Spica_0790	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
Spica_0792	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
Spica_0793	COG0037	tRNA processing
Spica_0796	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
Spica_0798	COG2198	Histidine kinase
Spica_0798	COG0643	Histidine kinase
Spica_0800	COG2201	protein-glutamate methylesterase activity
Spica_0801	COG0745	RESPONSE REGULATOR receiver
Spica_0802	COG0835	chemotaxis
Spica_0806	COG0481	GTPase activity
Spica_0807	COG2604	Protein of unknown function DUF115
Spica_0808	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
Spica_0811	COG0667	Aldo Keto reductase
Spica_0814	COG1609	Transcriptional regulator
Spica_0815	COG1869	D-ribose catabolic process
Spica_0816	COG1129	ABC transporter
Spica_0817	COG1172	Belongs to the binding-protein-dependent transport system permease family
Spica_0818	COG1879	ABC-type sugar transport system periplasmic component
Spica_0828	COG1175	transmembrane transport
Spica_0829	COG0395	ABC-type sugar transport system, permease component
Spica_0830	COG1609	Transcriptional regulator
Spica_0833	COG0545	Peptidyl-prolyl cis-trans isomerase
Spica_0834	COG0105	UTP biosynthetic process
Spica_0836	COG0559	Belongs to the binding-protein-dependent transport system permease family
Spica_0838	COG0411	ABC transporter
Spica_0840	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
Spica_0841	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
Spica_0842	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
Spica_0844	COG1472	Belongs to the glycosyl hydrolase 3 family
Spica_0845	COG0492	ferredoxin-NADP+ reductase activity
Spica_0846	COG0840	transmembrane signaling receptor activity
Spica_0849	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
Spica_0851	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
Spica_0853	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
Spica_0854	COG1475	DNA binding
Spica_0864	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
Spica_0864	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
Spica_0864	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
Spica_0874	COG1215	transferase activity, transferring glycosyl groups
Spica_0875	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
Spica_0876	COG0505	Belongs to the CarA family
Spica_0877	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
Spica_0878	COG0426	domain, Protein
Spica_0878	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
Spica_0880	COG2201	protein-glutamate methylesterase activity
Spica_0884	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
Spica_0885	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
Spica_0886	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
Spica_0887	COG0137	argininosuccinate synthase activity
Spica_0888	COG0165	Argininosuccinate lyase
Spica_0891	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
Spica_0896	COG0423	glycine-tRNA ligase activity
Spica_0917	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
Spica_0918	COG1744	ABC transporter substrate-binding protein PnrA-like
Spica_0922	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
Spica_0924	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
Spica_0926	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
Spica_0928	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
Spica_0929	COG2502	aspartate--ammonia ligase
Spica_0930	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
Spica_0931	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
Spica_0934	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
Spica_0937	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
Spica_0938	COG1396	sequence-specific DNA binding
Spica_0939	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
Spica_0940	COG0066	3-isopropylmalate dehydratase activity
Spica_0941	COG2814	Major facilitator Superfamily
Spica_0942	COG1811	Na channel or pump
Spica_0943	COG3842	ATPase activity
Spica_0945	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
Spica_0946	COG0557	exoribonuclease II activity
Spica_0947	COG0527	aspartate kinase activity
Spica_0948	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
Spica_0949	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
Spica_0952	COG0436	Aminotransferase
Spica_0954	COG2801	Transposase and inactivated derivatives
Spica_0958	COG2198	Histidine kinase
Spica_0958	COG0643	Histidine kinase
Spica_0959	COG0835	chemotaxis
Spica_0961	COG2201	protein-glutamate methylesterase activity
Spica_0962	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
Spica_0964	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
Spica_0966	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
Spica_0967	COG4191	Histidine kinase
Spica_0968	COG2204	response regulator
Spica_0969	COG0425	Belongs to the sulfur carrier protein TusA family
Spica_0971	COG2391	methyltransferase activity
Spica_0975	COG2723	6-phospho-beta-galactosidase activity
Spica_0976	COG1846	Transcriptional regulator
Spica_0976	COG1940	carbohydrate kinase activity
Spica_0978	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
Spica_0983	COG1181	Belongs to the D-alanine--D-alanine ligase family
Spica_0984	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
Spica_0986	COG2078	PFAM AMMECR1 domain protein
Spica_0988	COG0154	amidase activity
Spica_0989	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
Spica_0990	COG0017	Asparaginyl-tRNA synthetase
Spica_0993	COG2703	oxygen carrier activity
Spica_1009	COG3458	cephalosporin-C deacetylase activity
Spica_1013	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
Spica_1015	COG0564	pseudouridine synthase activity
Spica_1018	COG2716	regulation of RNA biosynthetic process
Spica_1019	COG0840	transmembrane signaling receptor activity
Spica_1021	COG1105	Belongs to the carbohydrate kinase PfkB family
Spica_1022	COG0534	Mate efflux family protein
Spica_1028	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
Spica_1029	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
Spica_1030	COG3630	sodium ion export across plasma membrane
Spica_1031	COG0511	ligase activity, forming carbon-carbon bonds
Spica_1031	COG5016	pyruvate
Spica_1033	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
Spica_1037	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
Spica_1039	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
Spica_1044	COG0295	cytidine deaminase activity
Spica_1045	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
Spica_1048	COG0564	pseudouridine synthase activity
Spica_1049	COG3330	Domain of unknown function (DUF4912)
Spica_1050	COG1543	Belongs to the glycosyl hydrolase 57 family
Spica_1053	COG2770	Histidine kinase
Spica_1053	COG2208	phosphoserine phosphatase activity
Spica_1057	COG0395	ABC-type sugar transport system, permease component
Spica_1066	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
Spica_1083	COG3328	transposase activity
Spica_1086	COG0037	tRNA processing
Spica_1088	COG1078	dGTPase activity
Spica_1089	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
Spica_1093	COG1366	Belongs to the anti-sigma-factor antagonist family
Spica_1095	COG0488	(ABC) transporter
Spica_1096	COG1272	protein, Hemolysin III
Spica_1097	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
Spica_1102	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
Spica_1104	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
Spica_1107	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
Spica_1108	COG0438	transferase activity, transferring glycosyl groups
Spica_1110	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
Spica_1111	COG0740	serine-type endopeptidase activity
Spica_1112	COG0544	peptidyl-prolyl cis-trans isomerase activity
Spica_1116	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
Spica_1117	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
Spica_1118	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
Spica_1119	COG2770	Histidine kinase
Spica_1119	COG3437	response regulator, receiver
Spica_1120	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
Spica_1121	COG0802	atpase or kinase
Spica_1126	COG1334	flagellar protein FlaG
Spica_1130	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
Spica_1133	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
Spica_1136	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
Spica_1140	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
Spica_1144	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
Spica_1144	COG0574	Belongs to the PEP-utilizing enzyme family
Spica_1147	COG0280	phosphate acetyltransferase
Spica_1151	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
Spica_1154	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
Spica_1155	COG1872	DUF167
Spica_1159	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
Spica_1162	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
Spica_1163	COG1162	GTPase activity
Spica_1164	COG1193	negative regulation of DNA recombination
Spica_1167	COG1438	arginine binding
Spica_1168	COG0166	Belongs to the GPI family
Spica_1177	COG0628	permease
Spica_1178	COG3830	Belongs to the UPF0237 family
Spica_1179	COG2848	UPF0210 protein
Spica_1181	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
Spica_1188	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
Spica_1190	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
Spica_1190	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
Spica_1192	COG4191	Histidine kinase
Spica_1193	COG2204	response regulator
Spica_1195	COG0330	HflC and HflK could
Spica_1196	COG0330	HflC and HflK could
Spica_1198	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
Spica_1199	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
Spica_1200	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
Spica_1201	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
Spica_1203	COG0736	holo-[acyl-carrier-protein] synthase activity
Spica_1205	COG0101	tRNA pseudouridine synthase activity
Spica_1206	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
Spica_1207	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
Spica_1208	COG1120	ATPase activity
Spica_1210	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
Spica_1213	COG1253	flavin adenine dinucleotide binding
Spica_1216	COG0436	Aminotransferase
Spica_1217	COG2604	Protein of unknown function DUF115
Spica_1218	COG0768	penicillin binding
Spica_1220	COG0739	heme binding
Spica_1222	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
Spica_1224	COG0726	polysaccharide deacetylase
Spica_1225	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
Spica_1228	COG1480	7TM receptor with intracellular HD hydrolase
Spica_1229	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
Spica_1236	COG0552	protein localization to endoplasmic reticulum
Spica_1238	COG4591	ABC-type transport system involved in lipoprotein release permease component
Spica_1239	COG1136	(ABC) transporter
Spica_1242	COG3869	Catalyzes the specific phosphorylation of arginine residues in
Spica_1243	COG0542	response to heat
Spica_1244	COG0179	Fumarylacetoacetate (FAA) hydrolase
Spica_1246	COG0386	Belongs to the glutathione peroxidase family
Spica_1247	COG1846	Transcriptional regulator
Spica_1249	COG1205	dead DEAH box helicase
Spica_1249	COG1111	helicase
Spica_1250	COG3359	exonuclease
Spica_1253	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
Spica_1254	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
Spica_1259	COG0438	transferase activity, transferring glycosyl groups
Spica_1260	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
Spica_1264	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
Spica_1266	COG0297	glycogen (starch) synthase activity
Spica_1269	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
Spica_1270	COG2267	carboxylic ester hydrolase activity
Spica_1271	COG0617	tRNA 3'-terminal CCA addition
Spica_1278	COG4658	electron transport chain
Spica_1281	COG4657	Part of a membrane complex involved in electron transport
Spica_1283	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
Spica_1283	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
Spica_1285	COG1234	tRNA 3'-trailer cleavage
Spica_1286	COG1131	(ABC) transporter
Spica_1298	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
Spica_1300	COG0681	Belongs to the peptidase S26 family
Spica_1302	COG0635	Involved in the biosynthesis of porphyrin-containing compound
Spica_1304	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
Spica_1304	COG0574	Belongs to the PEP-utilizing enzyme family
Spica_1307	COG1116	anion transmembrane transporter activity
Spica_1309	COG1122	ATPase activity
Spica_1310	COG1268	BioY protein
Spica_1312	COG0815	Transfers the fatty acyl group on membrane lipoproteins
Spica_1313	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
Spica_1317	COG0301	tRNA thio-modification
Spica_1318	COG1104	cysteine desulfurase activity
Spica_1320	COG0527	aspartate kinase activity
Spica_1320	COG0460	homoserine dehydrogenase
Spica_1321	COG0436	Aminotransferase
Spica_1323	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
Spica_1325	COG2801	Transposase and inactivated derivatives
Spica_1327	COG1091	dTDP-4-dehydrorhamnose reductase activity
Spica_1334	COG0124	histidyl-tRNA synthetase
Spica_1337	COG2089	acid synthase
Spica_1339	COG0217	transcriptional regulatory protein
Spica_1340	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
Spica_1341	COG0632	four-way junction helicase activity
Spica_1342	COG2255	four-way junction helicase activity
Spica_1343	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
Spica_1345	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
Spica_1347	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
Spica_1350	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
Spica_1351	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
Spica_1352	COG0779	Required for maturation of 30S ribosomal subunits
Spica_1354	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
Spica_1355	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
Spica_1356	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
Spica_1357	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
Spica_1358	COG1185	polyribonucleotide nucleotidyltransferase activity
Spica_1359	COG0612	Peptidase, M16
Spica_1362	COG0343	queuine tRNA-ribosyltransferase activity
Spica_1365	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
Spica_1365	COG1747	RNA polymerase binding
Spica_1367	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
Spica_1371	COG1490	D-aminoacyl-tRNA deacylase activity
Spica_1372	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
Spica_1373	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
Spica_1376	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
Spica_1378	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
Spica_1379	COG0539	negative regulation of cytoplasmic translation
Spica_1385	COG0772	Belongs to the SEDS family
Spica_1386	COG0768	penicillin binding
Spica_1389	COG1077	Cell shape determining protein MreB Mrl
Spica_1392	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
Spica_1393	COG0358	DNA primase activity
Spica_1394	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
Spica_1395	COG1404	Belongs to the peptidase S8 family
Spica_1395	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
Spica_1397	COG1234	tRNA 3'-trailer cleavage
Spica_1404	COG0571	ribonuclease III activity
Spica_1405	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
Spica_1406	COG0333	Belongs to the bacterial ribosomal protein bL32 family
Spica_1407	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
Spica_1409	COG1413	lyase activity
Spica_1412	COG0587	DNA-directed DNA polymerase activity
Spica_1415	COG0052	Belongs to the universal ribosomal protein uS2 family
Spica_1416	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
Spica_1417	COG0233	cytoplasmic translational termination
Spica_1418	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
Spica_1419	COG0575	Belongs to the CDS family
Spica_1420	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
Spica_1421	COG0750	zinc metalloprotease
Spica_1424	COG0305	Participates in initiation and elongation during chromosome replication
Spica_1425	COG0359	binds to the 23S rRNA
Spica_1427	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
Spica_1428	COG0629	single-stranded DNA binding
Spica_1429	COG0360	Binds together with S18 to 16S ribosomal RNA
Spica_1432	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
Spica_1435	COG0820	rRNA (adenine-C2-)-methyltransferase activity
Spica_1438	COG0494	nUDIX hydrolase
Spica_1441	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
Spica_1441	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
Spica_1443	COG0653	protein targeting
Spica_1448	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
Spica_1453	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
Spica_1455	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
Spica_1456	COG1132	(ABC) transporter
Spica_1461	COG3475	LICD family
Spica_1477	COG1643	Atp-dependent helicase
Spica_1480	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
Spica_1481	COG0220	tRNA (guanine-N7-)-methyltransferase activity
Spica_1495	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
Spica_1498	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
Spica_1501	COG1394	ATPase activity, coupled to movement of substances
Spica_1502	COG1156	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit
Spica_1503	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
Spica_1505	COG1390	Produces ATP from ADP in the presence of a proton gradient across the membrane
Spica_1509	COG2204	response regulator
Spica_1510	COG5002	protein histidine kinase activity
Spica_1512	COG1286	toxin biosynthetic process
Spica_1513	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
Spica_1517	COG0835	chemotaxis
Spica_1521	COG1191	sigma factor activity
Spica_1523	COG0455	bacterial-type flagellum organization
Spica_1526	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
Spica_1527	COG1684	flagellar biosynthetic protein fliR
Spica_1528	COG1987	bacterial-type flagellum assembly
Spica_1529	COG1338	Plays a role in the flagellum-specific transport system
Spica_1531	COG1776	CheC inhibitor of MCP methylation
Spica_1531	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
Spica_1532	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
Spica_1533	COG1580	Controls the rotational direction of flagella during chemotaxis
Spica_1534	COG1360	Flagellar Motor Protein
Spica_1536	COG1582	Flagellar protein (FlbD)
Spica_1538	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
Spica_1543	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
Spica_1551	COG1598	PFAM Uncharacterised protein family UPF0150
Spica_1552	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
Spica_1553	COG1573	uracil-dna glycosylase
Spica_1554	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
Spica_1557	COG1321	iron dependent repressor
Spica_1561	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
Spica_1562	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
Spica_1562	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
Spica_1563	COG1979	alcohol dehydrogenase
Spica_1577	COG1102	Psort location Cytoplasmic, score
Spica_1578	COG1561	YicC-like family, N-terminal region
Spica_1579	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
Spica_1580	COG0285	dihydrofolate synthase activity
Spica_1582	COG0564	pseudouridine synthase activity
Spica_1586	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
Spica_1591	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
Spica_1592	COG0785	Cytochrome C biogenesis protein
Spica_1595	COG1166	arginine decarboxylase activity
Spica_1600	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
Spica_1603	COG0254	rRNA binding
Spica_1604	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
Spica_1605	COG1058	Belongs to the CinA family
Spica_1605	COG1546	Belongs to the CinA family
Spica_1609	COG0815	Transfers the fatty acyl group on membrane lipoproteins
Spica_1611	COG0268	Binds directly to 16S ribosomal RNA
Spica_1615	COG1199	ATP-dependent helicase activity
Spica_1620	COG3706	GGDEF domain
Spica_1626	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
Spica_1627	COG0372	Belongs to the citrate synthase family
Spica_1628	COG0017	Asparaginyl-tRNA synthetase
Spica_1629	COG1686	Belongs to the peptidase S11 family
Spica_1635	COG1861	Spore coat polysaccharide biosynthesis protein F CMP-KDO synthetase
Spica_1637	COG0731	radical SAM domain protein
Spica_1638	COG1570	exodeoxyribonuclease VII activity
Spica_1639	COG1722	exodeoxyribonuclease VII activity
Spica_1640	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
Spica_1643	COG0084	hydrolase, TatD family'
Spica_1648	COG0004	ammonium transporteR
Spica_1650	COG1966	Carbon starvation protein
Spica_1652	COG0003	Pfam Anion-transporting ATPase
Spica_1655	COG1725	Transcriptional regulator
Spica_1656	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
Spica_1658	COG4865	methylaspartate mutase activity
Spica_1659	COG3799	methylaspartate ammonia-lyase activity
Spica_1665	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
Spica_1667	COG1157	protein secretion by the type III secretion system
Spica_1668	COG1317	bacterial-type flagellum organization
Spica_1670	COG1766	The M ring may be actively involved in energy transduction
Spica_1671	COG1677	Flagellar hook-basal body complex protein FliE
Spica_1673	COG1815	bacterial-type flagellum-dependent cell motility
Spica_1674	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
Spica_1675	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
Spica_1676	COG4974	Belongs to the 'phage' integrase family
Spica_1677	COG0551	DNA topoisomerase type I activity
Spica_1677	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
Spica_1678	COG0758	DNA mediated transformation
Spica_1684	COG0772	Belongs to the SEDS family
Spica_1685	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
Spica_1686	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
Spica_1688	COG0275	rRNA processing
Spica_1689	COG2001	Belongs to the MraZ family
Spica_1695	COG0191	fructose-bisphosphate aldolase activity
Spica_1697	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
Spica_1698	COG0291	Belongs to the bacterial ribosomal protein bL35 family
Spica_1699	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
Spica_1701	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
Spica_1703	COG1671	Belongs to the UPF0178 family
Spica_1704	COG3437	response regulator, receiver
Spica_1704	COG0784	Response regulator, receiver
Spica_1705	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
Spica_1707	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
Spica_1708	COG0508	dehydrogenase complex catalyzes the overall conversion of
Spica_1709	COG0508	dehydrogenase complex catalyzes the overall conversion of
Spica_1709	COG0022	dehydrogenase e1 component
Spica_1710	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
Spica_1712	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
Spica_1713	COG0581	inorganic phosphate transmembrane transporter activity
Spica_1714	COG0573	inorganic phosphate transmembrane transporter activity
Spica_1715	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
Spica_1718	COG0170	dolichyl monophosphate biosynthetic process
Spica_1725	COG4659	FMN binding
Spica_1727	COG0095	Lipoate-protein ligase
Spica_1729	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
Spica_1731	COG1715	Restriction endonuclease
Spica_1753	COG1715	Restriction endonuclease
Spica_1758	COG1715	Restriction endonuclease
Spica_1782	COG0406	alpha-ribazole phosphatase activity
Spica_1795	COG3328	transposase activity
Spica_1796	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
Spica_1803	COG0497	DNA recombination
Spica_1804	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
Spica_1806	COG0835	chemotaxis
Spica_1809	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
Spica_1810	COG0024	Methionine aminopeptidase
Spica_1811	COG0484	heat shock protein binding
Spica_1814	COG1394	ATPase activity, coupled to movement of substances
Spica_1815	COG1156	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit
Spica_1816	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
Spica_1820	COG1269	ATP hydrolysis coupled proton transport
Spica_1823	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
Spica_1824	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
Spica_1825	COG0149	triose-phosphate isomerase activity
Spica_1826	COG0126	phosphoglycerate kinase activity
Spica_1827	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
Spica_1829	COG0525	valine-tRNA ligase activity
Spica_1830	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
Spica_1831	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
Spica_1832	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
Spica_1833	COG1862	Preprotein translocase
Spica_1836	COG2033	superoxide reductase activity
Spica_1837	COG1592	Rubrerythrin
Spica_1844	COG0542	response to heat
Spica_1845	COG0737	Belongs to the 5'-nucleotidase family
Spica_1847	COG0519	Catalyzes the synthesis of GMP from XMP
Spica_1848	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
Spica_1849	COG0517	IMP dehydrogenase activity
Spica_1849	COG0516	GMP reductase activity
Spica_1850	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
Spica_1852	COG0561	phosphatase activity
Spica_1859	COG0070	glutamate synthase
Spica_1859	COG0069	glutamate synthase activity
Spica_1859	COG0067	glutamate synthase
Spica_1861	COG2972	Histidine kinase
Spica_1862	COG2207	Transcriptional regulator
Spica_1862	COG4753	response regulator
Spica_1863	COG4213	ABC transporter substrate-binding protein
Spica_1866	COG4211	Belongs to the binding-protein-dependent transport system permease family
Spica_1873	COG1160	GTP binding
Spica_1874	COG1027	Aspartate ammonia-lyase
Spica_1875	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
Spica_1882	COG3290	protein histidine kinase activity
Spica_1882	COG0840	transmembrane signaling receptor activity
Spica_1884	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
Spica_1884	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
Spica_1884	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
Spica_1887	COG2814	Major facilitator Superfamily
Spica_1889	COG0420	3'-5' exonuclease activity
Spica_1890	COG0419	ATPase involved in DNA repair
Spica_1892	COG1335	isochorismatase
Spica_1893	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
Spica_1894	COG0584	glycerophosphoryl diester phosphodiesterase
Spica_1896	COG1175	transmembrane transport
Spica_1897	COG0395	ABC-type sugar transport system, permease component
Spica_1899	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
Spica_1900	COG0765	amino acid transport
Spica_1901	COG0037	tRNA processing
Spica_1907	COG0395	ABC-type sugar transport system, permease component
Spica_1908	COG1175	transmembrane transport
Spica_1909	COG1653	transport
Spica_1910	COG2188	Transcriptional regulator
Spica_1917	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
Spica_1923	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
Spica_1924	COG1518	maintenance of DNA repeat elements
Spica_1931	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
Spica_1933	COG3525	Glycosyl hydrolase, family 20, catalytic domain
Spica_1936	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
Spica_1936	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
Spica_1937	COG0556	nucleotide-excision repair
Spica_1940	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
Spica_1940	COG0321	lipoyl(octanoyl) transferase activity
Spica_1941	COG0227	Belongs to the bacterial ribosomal protein bL28 family
Spica_1947	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
Spica_1957	COG0167	dihydroorotate dehydrogenase activity
Spica_1958	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
Spica_1961	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
Spica_1963	COG0745	RESPONSE REGULATOR receiver
Spica_1963	COG3706	GGDEF domain
Spica_1964	COG0587	DNA-directed DNA polymerase activity
Spica_1965	COG1609	Transcriptional regulator
Spica_1966	COG0436	Aminotransferase
Spica_1968	COG0828	Belongs to the bacterial ribosomal protein bS21 family
Spica_1969	COG0739	heme binding
Spica_1970	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
Spica_1970	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
Spica_1973	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
Spica_1973	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
Spica_1974	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
Spica_1979	COG0563	adenylate kinase activity
Spica_1980	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
Spica_1981	COG1349	DNA-binding transcription factor activity
Spica_1982	COG0508	dehydrogenase complex catalyzes the overall conversion of
Spica_1983	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
Spica_1988	COG1063	alcohol dehydrogenase
Spica_1993	COG1373	ATPase (AAA superfamily
Spica_1994	COG0840	transmembrane signaling receptor activity
Spica_2000	COG0577	efflux transmembrane transporter activity
Spica_2001	COG1136	(ABC) transporter
Spica_2001	COG0577	efflux transmembrane transporter activity
Spica_2002	COG1136	(ABC) transporter
Spica_2004	COG5002	protein histidine kinase activity
Spica_2005	COG0745	RESPONSE REGULATOR receiver
Spica_2007	COG4214	carbohydrate transport
Spica_2009	COG4213	ABC transporter substrate-binding protein
Spica_2010	COG4213	ABC transporter substrate-binding protein
Spica_2011	COG2197	response regulator
Spica_2012	COG2972	Histidine kinase
Spica_2014	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
Spica_2015	COG0542	response to heat
Spica_2016	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
Spica_2019	COG0708	Exodeoxyribonuclease III
Spica_2024	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
Spica_2028	COG1956	GAF domain-containing protein
Spica_2031	COG0601	transmembrane transport
Spica_2032	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
Spica_2033	COG0444	Belongs to the ABC transporter superfamily
Spica_2034	COG4608	Belongs to the ABC transporter superfamily
Spica_2035	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
Spica_2037	COG1028	Short-chain dehydrogenase reductase Sdr
Spica_2038	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
Spica_2039	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
Spica_2040	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
Spica_2042	COG0439	Biotin carboxylase
Spica_2043	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
Spica_2044	COG0825	malonyl-CoA metabolic process
Spica_2046	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
Spica_2048	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
Spica_2050	COG0629	single-stranded DNA binding
Spica_2052	COG2095	MarC family integral membrane protein
Spica_2056	COG0095	Lipoate-protein ligase
Spica_2064	COG5001	Diguanylate cyclase
Spica_2064	COG5002	protein histidine kinase activity
Spica_2066	COG0205	6-phosphofructokinase activity
Spica_2068	COG1501	Belongs to the glycosyl hydrolase 31 family
Spica_2070	COG2211	Major facilitator Superfamily
Spica_2076	COG1940	carbohydrate kinase activity
Spica_2077	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
Spica_2080	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
Spica_2084	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
Spica_2087	COG3959	Transketolase, thiamine diphosphate binding domain
Spica_2088	COG3958	Transketolase
Spica_2089	COG0698	ribose 5-phosphate isomerase
Spica_2090	COG1454	alcohol dehydrogenase
Spica_2094	COG0671	phosphoesterase, PA-phosphatase related
Spica_2095	COG3437	response regulator, receiver
Spica_2098	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
Spica_2107	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
Spica_2107	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
Spica_2108	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
Spica_2109	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
Spica_2113	COG0848	biopolymer transport protein
Spica_2114	COG0811	peptide transport
Spica_2124	COG3328	transposase activity
Spica_2127	COG2200	EAL domain
Spica_2128	COG0840	transmembrane signaling receptor activity
Spica_2129	COG1162	GTPase activity
Spica_2130	COG2197	response regulator
Spica_2131	COG4585	Histidine kinase
Spica_2133	COG4555	ABC transporter
Spica_2140	COG3842	ATPase activity
Spica_2141	COG1176	ABC-type spermidine putrescine transport system, permease component I
Spica_2142	COG1177	transmembrane transport
Spica_2143	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
Spica_2144	COG0009	L-threonylcarbamoyladenylate synthase
Spica_2146	COG2204	response regulator
Spica_2147	COG2972	Histidine kinase
Spica_2148	COG1609	Transcriptional regulator
Spica_2150	COG1172	Belongs to the binding-protein-dependent transport system permease family
Spica_2152	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
Spica_2153	COG1121	(ABC) transporter
Spica_2154	COG1108	ABC-type Mn2 Zn2 transport systems permease components
Spica_2157	COG0697	spore germination
Spica_2163	COG0583	DNA-binding transcription factor activity
Spica_2164	COG2855	membrane
Spica_2167	COG1914	H( )-stimulated, divalent metal cation uptake system
Spica_2169	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
Spica_2180	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
Spica_2183	COG2801	Transposase and inactivated derivatives
Spica_2213	COG2972	Histidine kinase
Spica_2214	COG2207	Transcriptional regulator
Spica_2214	COG4753	response regulator
Spica_2215	COG1879	ABC-type sugar transport system periplasmic component
Spica_2216	COG1879	ABC-type sugar transport system periplasmic component
Spica_2217	COG1129	ABC transporter
Spica_2218	COG1172	Belongs to the binding-protein-dependent transport system permease family
Spica_2219	COG1172	Belongs to the binding-protein-dependent transport system permease family
Spica_2222	COG0395	ABC-type sugar transport system, permease component
Spica_2224	COG1609	Transcriptional regulator
Spica_2234	COG0123	including yeast histone deacetylase and acetoin utilization protein
Spica_2239	COG1136	(ABC) transporter
Spica_2241	COG1725	Transcriptional regulator
Spica_2245	COG4154	Belongs to the RbsD FucU family
Spica_2247	COG1063	alcohol dehydrogenase
Spica_2248	COG1105	Belongs to the carbohydrate kinase PfkB family
Spica_2250	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
Spica_2252	COG3711	transcriptional antiterminator
Spica_2256	COG0534	Mate efflux family protein
Spica_2258	COG0288	reversible hydration of carbon dioxide
Spica_2261	COG2746	aminoglycoside 3-N-acetyltransferase activity
Spica_2262	COG2217	Heavy metal translocating P-type atpase
Spica_2263	COG0640	Transcriptional regulator
Spica_2266	COG0494	nUDIX hydrolase
Spica_2270	COG0659	secondary active sulfate transmembrane transporter activity
Spica_2273	COG1132	(ABC) transporter
Spica_2283	COG4585	Histidine kinase
Spica_2284	COG2197	response regulator
Spica_2285	COG1653	transport
Spica_2286	COG1175	transmembrane transport
Spica_2289	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
Spica_2293	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
Spica_2298	COG2272	Belongs to the type-B carboxylesterase lipase family
Spica_2301	COG1247	-acetyltransferase
Spica_2306	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
Spica_2308	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
Spica_2309	COG0714	Associated with various cellular activities
Spica_2315	COG0714	Associated with various cellular activities
Spica_2317	COG1172	Belongs to the binding-protein-dependent transport system permease family
Spica_2318	COG1129	ABC transporter
Spica_2319	COG1879	ABC-type sugar transport system periplasmic component
Spica_2320	COG1879	ABC-type sugar transport system periplasmic component
Spica_2321	COG2972	Histidine kinase
Spica_2322	COG2207	Transcriptional regulator
Spica_2322	COG4753	response regulator
Spica_2323	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
Spica_2326	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
Spica_2328	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
Spica_2330	COG1022	Amp-dependent synthetase and ligase
Spica_2333	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
Spica_2334	COG0242	peptide deformylase activity
Spica_2335	COG4953	penicillin-binding protein 1C
Spica_2337	COG5001	Diguanylate cyclase
Spica_2337	COG4251	negative regulation of phosphorylation
Spica_2337	COG3706	GGDEF domain
Spica_2337	COG2203	Gaf domain
Spica_2338	COG2201	protein-glutamate methylesterase activity
Spica_2339	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
Spica_2340	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
Spica_2342	COG0835	chemotaxis
Spica_2344	COG0643	Histidine kinase
Spica_2344	COG2198	Histidine kinase
Spica_2347	COG1063	alcohol dehydrogenase
Spica_2348	COG0656	L-ascorbic acid biosynthetic process
Spica_2351	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
Spica_2352	COG1193	negative regulation of DNA recombination
Spica_2357	COG0404	The glycine cleavage system catalyzes the degradation of glycine
Spica_2358	COG0509	glycine decarboxylation via glycine cleavage system
Spica_2360	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
Spica_2363	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
Spica_2365	COG2226	methyltransferase
Spica_2367	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
Spica_2369	COG0693	protein deglycase activity
Spica_2370	COG0745	RESPONSE REGULATOR receiver
Spica_2371	COG5002	protein histidine kinase activity
Spica_2371	COG0784	Response regulator, receiver
Spica_2371	COG2205	protein histidine kinase activity
Spica_2372	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
Spica_2374	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
Spica_2382	COG0714	Associated with various cellular activities
Spica_2390	COG0012	GTP binding
Spica_2392	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
Spica_2394	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
Spica_2398	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
Spica_2399	COG0840	transmembrane signaling receptor activity
Spica_2401	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
Spica_2401	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
Spica_2405	COG2183	response to ionizing radiation
Spica_2408	COG3290	protein histidine kinase activity
Spica_2408	COG0840	transmembrane signaling receptor activity
Spica_2410	COG3527	Alpha-acetolactate decarboxylase
Spica_2412	COG0840	transmembrane signaling receptor activity
Spica_2413	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
Spica_2414	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
Spica_2416	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
Spica_2417	COG0138	bifunctional purine biosynthesis protein purh
Spica_2418	COG0151	Belongs to the GarS family
Spica_2419	COG1309	transcriptional regulator
Spica_2420	COG0395	ABC-type sugar transport system, permease component
Spica_2421	COG4209	transmembrane transport
Spica_2423	COG1132	(ABC) transporter
Spica_2424	COG1132	(ABC) transporter
Spica_2428	COG0318	PFAM AMP-dependent synthetase and ligase
Spica_2431	COG1053	succinate dehydrogenase
Spica_2432	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
Spica_2433	COG0131	Imidazoleglycerol-phosphate dehydratase
Spica_2434	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
Spica_2436	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
Spica_2436	COG0140	phosphoribosyl-ATP diphosphatase activity
Spica_2437	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
Spica_2438	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
Spica_2444	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
Spica_2452	COG0395	ABC-type sugar transport system, permease component
Spica_2453	COG4209	transmembrane transport
Spica_2454	COG1653	transport
Spica_2471	COG1846	Transcriptional regulator
Spica_2471	COG1940	carbohydrate kinase activity
Spica_2472	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
Spica_2473	COG0363	glucosamine-6-phosphate deaminase activity
Spica_2475	COG2239	Acts as a magnesium transporter
Spica_2476	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
Spica_2477	COG1993	acr, cog1993
Spica_2482	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
Spica_2484	COG0674	pyruvate-flavodoxin oxidoreductase activity
Spica_2484	COG1013	pyruvate-flavodoxin oxidoreductase activity
Spica_2484	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
Spica_2484	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
Spica_2486	COG0438	transferase activity, transferring glycosyl groups
Spica_2487	COG2610	gluconate transmembrane transporter activity
Spica_2488	COG3956	TIGRFAM MazG family protein
Spica_2489	COG0193	aminoacyl-tRNA hydrolase activity
Spica_2490	COG3345	alpha-galactosidase
Spica_2491	COG0517	IMP dehydrogenase activity
Spica_2491	COG1227	inorganic diphosphatase activity
Spica_2494	COG0740	serine-type endopeptidase activity
Spica_2496	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
Spica_2498	COG2759	Belongs to the formate--tetrahydrofolate ligase family
Spica_2499	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
Spica_2505	COG0765	amino acid transport
Spica_2506	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
Spica_2509	COG0778	Nitroreductase
Spica_2511	COG0728	peptidoglycan biosynthetic process
Spica_2512	COG0584	glycerophosphoryl diester phosphodiesterase
Spica_2516	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
Spica_2517	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
Spica_2518	COG2217	Heavy metal translocating P-type atpase
Spica_2519	COG2608	mercury ion transmembrane transporter activity
Spica_2528	COG1012	belongs to the aldehyde dehydrogenase family
Spica_2529	COG2252	PERMEase
Spica_2535	COG4608	Belongs to the ABC transporter superfamily
Spica_2536	COG0444	Belongs to the ABC transporter superfamily
Spica_2537	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
Spica_2538	COG0601	transmembrane transport
Spica_2539	COG4166	transmembrane transport
Spica_2553	COG0543	2 iron, 2 sulfur cluster binding
Spica_2554	COG0167	dihydroorotate dehydrogenase activity
Spica_2560	COG1160	GTP binding
Spica_2566	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
Spica_2567	COG0724	RNA recognition motif
Spica_2574	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
Spica_2575	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
Spica_2576	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
Spica_2577	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
Spica_2578	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
Spica_2579	COG5000	phosphorelay sensor kinase activity
Spica_2580	COG2204	response regulator
Spica_2583	COG1252	NADH dehydrogenase
Spica_2586	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
Spica_2587	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
Spica_2588	COG0248	Ppx GppA phosphatase
Spica_2590	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
Spica_2591	COG2062	phosphohistidine phosphatase, SixA
Spica_2598	COG4771	TonB-dependent receptor
Spica_2600	COG0765	amino acid transport
Spica_2603	COG0745	RESPONSE REGULATOR receiver
Spica_2604	COG2205	protein histidine kinase activity
Spica_2605	COG1131	(ABC) transporter
Spica_2610	COG0724	RNA recognition motif
Spica_2611	COG0840	transmembrane signaling receptor activity
Spica_2614	COG1640	4-alpha-glucanotransferase
Spica_2617	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
Spica_2619	COG0765	amino acid transport
Spica_2621	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
Spica_2622	COG0640	Transcriptional regulator
Spica_2625	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
Spica_2626	COG1609	Transcriptional regulator
Spica_2627	COG0519	Catalyzes the synthesis of GMP from XMP
Spica_2630	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
Spica_2631	COG2207	Transcriptional regulator
Spica_2631	COG4753	response regulator
Spica_2632	COG3275	phosphorelay sensor kinase activity
Spica_2633	COG2199	diguanylate cyclase activity
Spica_2633	COG2203	Gaf domain
Spica_2634	COG0791	NLP P60 protein
Spica_2639	COG0280	phosphate acetyltransferase
Spica_2640	COG3426	butyrate kinase activity
Spica_2643	COG2195	Cleaves the N-terminal amino acid of tripeptides
Spica_2648	COG1131	(ABC) transporter
Spica_2650	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
Spica_2651	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
Spica_2652	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
Spica_2654	COG0488	(ABC) transporter
Spica_2658	COG1129	ABC transporter
Spica_2659	COG1744	ABC transporter substrate-binding protein PnrA-like
Spica_2664	COG2337	Toxic component of a toxin-antitoxin (TA) module
Spica_2668	COG0564	pseudouridine synthase activity
Spica_2670	COG0501	Belongs to the peptidase M48B family
Spica_2671	COG0028	Belongs to the TPP enzyme family
Spica_2673	COG0473	3-isopropylmalate dehydrogenase activity
Spica_2674	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
Spica_2676	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
Spica_2677	COG0440	acetolactate synthase activity
Spica_2678	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
Spica_2683	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
Spica_2686	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
Spica_2686	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
Spica_2687	COG0129	dihydroxy-acid dehydratase activity
Spica_2688	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
Spica_2689	COG0066	3-isopropylmalate dehydratase activity
Spica_2690	COG0028	Belongs to the TPP enzyme family
Spica_2691	COG0440	acetolactate synthase activity
Spica_2692	COG0477	Major facilitator Superfamily
Spica_2695	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
Spica_2697	COG0732	type I restriction modification DNA specificity domain
Spica_2702	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
Spica_2704	COG1598	PFAM Uncharacterised protein family UPF0150
Spica_2705	COG5002	protein histidine kinase activity
Spica_2706	COG0009	L-threonylcarbamoyladenylate synthase
Spica_2708	COG0598	Magnesium transport protein CorA
Spica_2709	COG3250	beta-galactosidase activity
Spica_2709	COG5297	Belongs to the glycosyl hydrolase family 6
Spica_2712	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
Spica_2714	COG0495	leucyl-tRNA aminoacylation
Spica_2715	COG0662	Cupin 2, conserved barrel domain protein
Spica_2717	COG0438	transferase activity, transferring glycosyl groups
Spica_2719	COG0006	proline dipeptidase activity
Spica_2722	COG0446	pyridine nucleotide-disulphide oxidoreductase
Spica_2723	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
Spica_2726	COG1639	'signal transduction protein
Spica_2729	COG0322	excinuclease ABC activity
Spica_2733	COG1876	peptidase activity
Spica_2737	COG0572	uridine kinase
Spica_2738	COG0733	neurotransmitter:sodium symporter activity
Spica_2739	COG0484	heat shock protein binding
Spica_2740	COG0443	Heat shock 70 kDa protein
Spica_2741	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
Spica_2743	COG1968	undecaprenyl-diphosphatase activity
Spica_2744	COG1187	pseudouridine synthase activity
Spica_2746	COG1070	Carbohydrate kinase
Spica_2748	COG0745	RESPONSE REGULATOR receiver
Spica_2749	COG3920	Histidine kinase
Spica_2751	COG1127	ABC transporter
Spica_2755	COG2884	Cell division ATP-binding protein ftsE
Spica_2758	COG1692	metallophosphoesterase
Spica_2759	COG1418	mRNA catabolic process
Spica_2760	COG1137	ATPase activity
Spica_2766	COG2201	protein-glutamate methylesterase activity
Spica_2768	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
Spica_2770	COG1692	metallophosphoesterase
Spica_2779	COG0318	PFAM AMP-dependent synthetase and ligase
Spica_2783	COG0516	GMP reductase activity
Spica_2783	COG0517	IMP dehydrogenase activity
Spica_2784	COG0561	phosphatase activity
Spica_2787	COG1192	Involved in chromosome partitioning
Spica_2788	COG1475	DNA binding
Spica_2790	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
Spica_2792	COG1350	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
Spica_2793	COG1215	transferase activity, transferring glycosyl groups
Spica_2801	COG4120	Belongs to the binding-protein-dependent transport system permease family
Spica_2803	COG0281	malic enzyme
Spica_2806	COG3775	system Galactitol-specific IIC component
Spica_2807	COG0442	prolyl-tRNA aminoacylation
Spica_2809	COG0058	SHG alpha-glucan phosphorylase activity
Spica_2811	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
Spica_2812	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
Spica_2813	COG4214	carbohydrate transport
Spica_2814	COG1129	ABC transporter
Spica_2815	COG4213	ABC transporter substrate-binding protein
Spica_2816	COG1349	DNA-binding transcription factor activity
Spica_2817	COG1129	ABC transporter
Spica_2819	COG2160	L-arabinose isomerase activity
Spica_2821	COG0534	Mate efflux family protein
Spica_2826	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
Spica_2827	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
Spica_2828	COG2084	Dehydrogenase
Spica_2831	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
Spica_2832	COG1410	methionine synthase
Spica_2832	COG0646	methionine synthase
Spica_2836	COG4502	5' nucleotidase, deoxy (Pyrimidine), cytosolic type C protein (NT5C)
Spica_2837	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
Spica_2843	COG0569	domain protein
Spica_2844	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
Spica_2846	COG0395	ABC-type sugar transport system, permease component
Spica_2847	COG1175	transmembrane transport
Spica_2848	COG1653	transport
Spica_2850	COG1063	alcohol dehydrogenase
Spica_2852	COG0714	Associated with various cellular activities
Spica_2855	COG3339	Conserved Protein
Spica_2857	COG1022	Amp-dependent synthetase and ligase
Spica_2858	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
Spica_2859	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
Spica_2868	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
Spica_2869	COG0187	DNA topoisomerase II activity
Spica_R0030	COG0826	peptidase U32